                         SEQUENCE LISTING

<110>  bioMrieux
 
<120>  Polypeptides muts de HEV et leur utilisation pour le dosage 
       d'anticorps anti-HEV

<130>  Mutacys

<150>  FR1561596
<151>  2015-11-30

<160>  50    

<170>  PatentIn version 3.5

<210>  1
<211>  674
<212>  PRT
<213>  Hepatitis E virus

<400>  1

Met Asn Asn Met Phe Phe Cys Ser Val His Gly Asp Ala Thr Met Arg 
1               5                   10                  15      


Ser Arg Ala Phe Leu Phe Leu Phe Leu Val Leu Leu Pro Met Leu Pro 
            20                  25                  30          


Ala Pro Pro Ala Gly Gln Pro Ser Gly Arg Arg Arg Gly Arg Arg Ser 
        35                  40                  45              


Gly Gly Ala Gly Gly Gly Phe Trp Gly Asp Arg Val Asp Ser Gln Pro 
    50                  55                  60                  


Phe Ala Leu Pro Tyr Ile His Pro Thr Asn Pro Phe Ala Ser Asp Ile 
65                  70                  75                  80  


Pro Ala Ala Ala Gly Ala Gly Ala Arg Pro Arg Gln Pro Ala Arg Pro 
                85                  90                  95      


Leu Gly Ser Ala Trp Arg Asp Gln Ser Gln Arg Pro Ala Thr Ser Ala 
            100                 105                 110         


Arg Arg Arg Ser Ala Pro Ala Gly Ala Ser Pro Leu Thr Ala Val Ala 
        115                 120                 125             


Pro Ala Pro Asp Thr Ala Pro Val Pro Asp Val Asp Ser Arg Gly Ala 
    130                 135                 140                 


Ile Leu Arg Arg Gln Tyr Asn Leu Ser Thr Ser Pro Leu Thr Ser Thr 
145                 150                 155                 160 


Ile Ala Thr Gly Thr Asn Leu Val Leu Tyr Ala Ala Pro Leu Ser Pro 
                165                 170                 175     


Leu Leu Pro Leu Gln Asp Gly Thr Asn Thr His Ile Met Ala Thr Glu 
            180                 185                 190         


Ala Ser Asn Tyr Ala Gln Tyr Arg Val Val Arg Ala Thr Ile Arg Tyr 
        195                 200                 205             


Arg Pro Leu Val Pro Asn Ala Val Gly Gly Tyr Ala Ile Ser Ile Ser 
    210                 215                 220                 


Phe Trp Pro Gln Thr Thr Thr Thr Pro Thr Ser Val Asp Met Asn Ser 
225                 230                 235                 240 


Ile Thr Ser Thr Asp Val Arg Ile Leu Val Gln Pro Gly Ile Ala Ser 
                245                 250                 255     


Glu Leu Val Ile Pro Ser Glu Arg Leu His Tyr Arg Asn Gln Gly Trp 
            260                 265                 270         


Arg Ser Val Glu Thr Ser Gly Val Ala Glu Glu Glu Ala Thr Ser Gly 
        275                 280                 285             


Leu Val Met Leu Cys Ile His Gly Ser Pro Val Asn Ser Tyr Thr Asn 
    290                 295                 300                 


Thr Pro Tyr Thr Gly Ala Leu Gly Leu Leu Asp Phe Ala Leu Glu Leu 
305                 310                 315                 320 


Glu Phe Arg Asn Leu Thr Pro Gly Asn Thr Asn Thr Arg Val Ser Arg 
                325                 330                 335     


Tyr Ser Ser Ser Ala Arg His Lys Leu Arg Arg Gly Pro Asp Gly Thr 
            340                 345                 350         


Ala Glu Leu Thr Thr Thr Ala Ala Thr Arg Phe Met Lys Asp Leu His 
        355                 360                 365             


Phe Thr Gly Thr Asn Gly Val Gly Glu Val Gly Arg Gly Ile Ala Leu 
    370                 375                 380                 


Thr Leu Phe Asn Leu Ala Asp Thr Leu Leu Gly Gly Leu Pro Thr Glu 
385                 390                 395                 400 


Leu Ile Ser Ser Ala Gly Gly Gln Leu Phe Tyr Ser Arg Pro Val Val 
                405                 410                 415     


Ser Ala Asn Gly Glu Pro Thr Val Lys Leu Tyr Thr Ser Val Glu Asn 
            420                 425                 430         


Ala Gln Gln Asp Lys Gly Ile Ala Ile Pro His Asp Ile Asp Leu Gly 
        435                 440                 445             


Glu Ser Arg Val Val Ile Gln Asp Tyr Asp Asn Gln His Glu Gln Asp 
    450                 455                 460                 


Arg Pro Thr Pro Ser Pro Ala Pro Ser Arg Pro Phe Ser Val Leu Arg 
465                 470                 475                 480 


Ala Asn Asp Val Leu Trp Leu Ser Leu Thr Ala Ala Glu Tyr Asp Gln 
                485                 490                 495     


Thr Thr Tyr Gly Ser Ser Thr Asn Pro Met Tyr Val Ser Asp Thr Val 
            500                 505                 510         


Thr Phe Val Asn Val Ala Thr Gly Ala Gln Gly Val Ser Arg Ser Leu 
        515                 520                 525             


Asp Trp Ser Lys Val Thr Leu Asp Gly Arg Pro Leu Met Thr Ile Gln 
    530                 535                 540                 


Gln Tyr Ser Lys Thr Phe Phe Val Leu Pro Leu Arg Gly Lys Leu Ser 
545                 550                 555                 560 


Phe Trp Glu Ala Gly Thr Thr Lys Ala Gly Tyr Pro Tyr Asn Tyr Asn 
                565                 570                 575     


Thr Thr Ala Ser Asp Gln Ile Leu Ile Glu Asn Ala Ala Gly His Arg 
            580                 585                 590         


Val Cys Ile Ser Thr Tyr Thr Thr Asn Leu Gly Ser Gly Pro Val Ser 
        595                 600                 605             


Ile Ser Ala Val Gly Val Leu Ala Pro His Ser Ala Leu Ala Ala Leu 
    610                 615                 620                 


Glu Asp Thr Val Asp Tyr Pro Ala Arg Ala His Thr Phe Asp Asp Phe 
625                 630                 635                 640 


Cys Pro Glu Cys Arg Ala Leu Gly Leu Gln Gly Cys Ala Phe Gln Ser 
                645                 650                 655     


Thr Val Ala Glu Leu Gln Arg Leu Lys Met Lys Val Gly Lys Thr Arg 
            660                 665                 670         


Glu Tyr 
        


<210>  2
<211>  674
<212>  PRT
<213>  Hepatitis E virus

<400>  2

Met Asn Asn Met Phe Phe Cys Ser Val His Gly Asp Ala Thr Met Arg 
1               5                   10                  15      


Ser Arg Ala Leu Leu Phe Leu Leu Phe Val Leu Leu Pro Met Leu Pro 
            20                  25                  30          


Ala Pro Pro Ala Gly Gln Pro Ser Gly Arg Arg Arg Gly Arg Arg Ser 
        35                  40                  45              


Gly Gly Ala Gly Gly Gly Phe Trp Gly Asp Arg Val Asp Ser Gln Pro 
    50                  55                  60                  


Phe Ala Leu Pro Tyr Ile His Pro Thr Asn Pro Phe Ala Ser Asp Ile 
65                  70                  75                  80  


Pro Thr Ala Ala Gly Ser Gly Ala Arg Pro Arg Gln Pro Ala Arg Pro 
                85                  90                  95      


Leu Gly Ser Ala Trp Arg Asp Gln Ser Gln Arg Pro Ala Ala Pro Ala 
            100                 105                 110         


Arg Arg Arg Ser Ala Pro Ala Gly Ala Ser Pro Leu Thr Ala Val Ala 
        115                 120                 125             


Pro Ala Pro Asp Thr Ala Pro Val Pro Asp Val Asp Ser Arg Gly Ala 
    130                 135                 140                 


Ile Leu Arg Arg Gln Tyr Asn Leu Ser Thr Ser Pro Leu Thr Ser Thr 
145                 150                 155                 160 


Ile Ala Thr Gly Thr Asn Leu Val Leu Tyr Ala Ala Pro Leu Ser Pro 
                165                 170                 175     


Leu Leu Pro Leu Gln Asp Gly Thr Asn Thr His Ile Met Ala Thr Glu 
            180                 185                 190         


Ala Ser Asn Tyr Ala Gln Tyr Arg Val Val Arg Ala Thr Ile Arg Tyr 
        195                 200                 205             


Arg Pro Leu Val Pro Asn Ala Val Gly Gly Tyr Ala Ile Ser Ile Ser 
    210                 215                 220                 


Phe Trp Pro Gln Thr Thr Thr Thr Pro Thr Ser Val Asp Met Asn Ser 
225                 230                 235                 240 


Ile Thr Ser Thr Asp Val Arg Ile Leu Val Gln Pro Gly Ile Ala Ser 
                245                 250                 255     


Glu Leu Val Ile Pro Ser Glu Arg Leu His Tyr Arg Asn Gln Gly Trp 
            260                 265                 270         


Arg Ser Val Glu Thr Ser Gly Val Ala Glu Glu Glu Ala Thr Ser Gly 
        275                 280                 285             


Leu Val Met Leu Cys Ile His Gly Ser Pro Val Asn Ser Tyr Thr Asn 
    290                 295                 300                 


Thr Pro Tyr Thr Gly Ala Leu Gly Leu Leu Asp Phe Ala Leu Glu Leu 
305                 310                 315                 320 


Glu Phe Arg Asn Leu Thr Pro Gly Asn Thr Asn Thr Arg Val Ser Arg 
                325                 330                 335     


Tyr Ser Ser Ser Ala Arg His Lys Leu Arg Arg Gly Pro Asp Gly Thr 
            340                 345                 350         


Ala Glu Leu Thr Thr Thr Ala Ala Thr Arg Phe Met Lys Asp Leu His 
        355                 360                 365             


Phe Thr Gly Thr Asn Gly Val Gly Glu Val Gly Arg Gly Ile Ala Leu 
    370                 375                 380                 


Thr Leu Phe Asn Leu Ala Asp Thr Leu Leu Gly Gly Leu Pro Thr Glu 
385                 390                 395                 400 


Leu Ile Ser Ser Ala Gly Gly Gln Leu Phe Tyr Ser Arg Pro Val Val 
                405                 410                 415     


Ser Ala Asn Gly Glu Pro Thr Val Lys Leu Tyr Thr Ser Val Glu Asn 
            420                 425                 430         


Ala Gln Gln Asp Lys Gly Ile Ala Ile Pro His Asp Ile Asp Leu Gly 
        435                 440                 445             


Glu Ser Arg Val Val Ile Gln Asp Tyr Asp Asn Gln His Glu Gln Asp 
    450                 455                 460                 


Arg Pro Thr Pro Ser Pro Ala Pro Ser Arg Pro Phe Ser Val Leu Arg 
465                 470                 475                 480 


Ala Asn Asp Val Leu Trp Leu Ser Leu Thr Ala Ala Glu Tyr Asp Gln 
                485                 490                 495     


Thr Thr Tyr Gly Ser Ser Thr Asn Pro Met Tyr Val Ser Asp Thr Val 
            500                 505                 510         


Thr Phe Val Asn Val Ala Thr Gly Ala Gln Gly Val Ser Arg Ser Leu 
        515                 520                 525             


Asp Trp Ser Lys Val Thr Leu Asp Gly Arg Pro Leu Thr Thr Ile Gln 
    530                 535                 540                 


Gln Tyr Ser Lys Thr Phe Phe Val Leu Pro Leu Arg Gly Lys Leu Ser 
545                 550                 555                 560 


Phe Trp Glu Ala Gly Thr Thr Lys Ala Gly Tyr Pro Tyr Asn Tyr Asn 
                565                 570                 575     


Thr Thr Ala Ser Asp Gln Ile Leu Ile Glu Asn Ala Ala Gly His Arg 
            580                 585                 590         


Val Cys Ile Ser Thr Tyr Thr Thr Asn Leu Gly Ser Gly Pro Val Ser 
        595                 600                 605             


Ile Ser Ser Val Gly Val Leu Ala Pro His Ser Ala Leu Ala Ala Leu 
    610                 615                 620                 


Glu Asp Thr Val Asp Tyr Pro Ala Arg Ala His Thr Phe Asp Asp Phe 
625                 630                 635                 640 


Cys Pro Glu Cys Arg Thr Leu Gly Leu Gln Gly Cys Ala Phe Gln Ser 
                645                 650                 655     


Thr Val Ala Glu Leu Gln Arg Leu Lys Met Lys Val Gly Lys Thr Arg 
            660                 665                 670         


Glu Tyr 
        


<210>  3
<211>  674
<212>  PRT
<213>  Hepatitis E virus

<400>  3

Met Asn Asn Met Phe Phe Cys Ser Val His Gly Asp Ala Thr Met Arg 
1               5                   10                  15      


Ser Arg Ala Leu Leu Phe Leu Leu Phe Val Leu Leu Pro Met Leu Pro 
            20                  25                  30          


Ala Pro Pro Ala Gly Gln Pro Ser Gly Arg Arg Arg Gly Arg Arg Ser 
        35                  40                  45              


Gly Gly Ala Gly Gly Gly Phe Trp Gly Asp Arg Val Asp Ser Gln Pro 
    50                  55                  60                  


Phe Ala Leu Pro Tyr Ile His Pro Thr Asn Pro Phe Ala Ser Asp Ile 
65                  70                  75                  80  


Pro Thr Ala Ala Gly Ser Gly Ala Arg Pro Arg Gln Pro Ala Arg Pro 
                85                  90                  95      


Leu Gly Ser Ala Trp Arg Asp Gln Ser Gln Arg Pro Ala Ala Ser Ala 
            100                 105                 110         


Arg Arg Arg Ser Ala Pro Ala Gly Ala Ser Pro Leu Thr Ala Val Ala 
        115                 120                 125             


Pro Ala Pro Asp Thr Ala Pro Val Pro Asp Val Asp Ser Arg Gly Ala 
    130                 135                 140                 


Ile Leu Arg Arg Gln Tyr Asn Leu Ser Thr Ser Pro Leu Thr Ser Thr 
145                 150                 155                 160 


Ile Ala Thr Gly Thr Asn Leu Val Leu Tyr Ala Ala Pro Leu Ser Pro 
                165                 170                 175     


Leu Leu Pro Leu Gln Asp Gly Thr Asn Thr His Ile Met Ala Thr Glu 
            180                 185                 190         


Ala Ser Asn Tyr Ala Gln Tyr Arg Val Val Arg Ala Thr Ile Arg Tyr 
        195                 200                 205             


Arg Pro Leu Val Pro Asn Ala Val Gly Gly Tyr Ala Ile Ser Ile Ser 
    210                 215                 220                 


Phe Trp Pro Gln Thr Thr Thr Thr Pro Thr Ser Val Asp Met Asn Ser 
225                 230                 235                 240 


Ile Thr Ser Thr Asp Val Arg Ile Leu Val Gln Pro Gly Ile Ala Ser 
                245                 250                 255     


Glu Leu Val Ile Pro Ser Glu Arg Leu His Tyr Arg Asn Gln Gly Trp 
            260                 265                 270         


Arg Ser Val Glu Thr Ser Gly Val Ala Glu Glu Glu Ala Thr Ser Gly 
        275                 280                 285             


Leu Val Met Leu Cys Ile His Gly Ser Pro Val Asn Ser Tyr Thr Asn 
    290                 295                 300                 


Thr Pro Tyr Thr Gly Ala Leu Gly Leu Leu Asp Phe Ala Leu Glu Leu 
305                 310                 315                 320 


Glu Phe Arg Asn Leu Thr Pro Gly Asn Thr Asn Thr Arg Val Ser Arg 
                325                 330                 335     


Tyr Ser Ser Ser Ala Arg His Lys Leu Arg Arg Gly Pro Asp Gly Thr 
            340                 345                 350         


Ala Glu Leu Thr Thr Thr Ala Ala Thr Arg Phe Met Lys Asp Leu His 
        355                 360                 365             


Phe Thr Gly Thr Asn Gly Val Gly Glu Val Gly Arg Gly Ile Ala Leu 
    370                 375                 380                 


Thr Leu Phe Asn Leu Ala Asp Thr Leu Leu Gly Gly Leu Pro Thr Glu 
385                 390                 395                 400 


Leu Ile Ser Ser Ala Gly Gly Gln Leu Phe Tyr Ser Arg Pro Val Val 
                405                 410                 415     


Ser Ala Asn Gly Glu Pro Thr Val Lys Leu Tyr Thr Ser Val Glu Asn 
            420                 425                 430         


Ala Gln Gln Asp Lys Gly Ile Ala Ile Pro His Asp Ile Asp Leu Gly 
        435                 440                 445             


Glu Ser Arg Val Val Ile Gln Asp Tyr Asp Asn Gln His Glu Gln Asp 
    450                 455                 460                 


Arg Pro Thr Pro Ser Pro Ala Pro Ser Arg Pro Phe Ser Val Leu Arg 
465                 470                 475                 480 


Ala Asn Asp Val Leu Trp Leu Ser Leu Thr Ala Ala Glu Tyr Asp Gln 
                485                 490                 495     


Thr Thr Tyr Gly Ser Ser Thr Asn Pro Met Tyr Val Ser Asp Thr Val 
            500                 505                 510         


Thr Phe Val Asn Val Ala Thr Gly Ala Gln Gly Val Ser Arg Ser Leu 
        515                 520                 525             


Asp Trp Ser Lys Val Thr Leu Asp Gly Arg Pro Leu Thr Thr Ile Gln 
    530                 535                 540                 


Gln Tyr Ser Lys Thr Phe Phe Val Leu Pro Leu Arg Gly Lys Leu Ser 
545                 550                 555                 560 


Phe Trp Glu Ala Gly Thr Thr Lys Ala Gly Tyr Pro Tyr Asn Tyr Asn 
                565                 570                 575     


Thr Thr Ala Ser Asp Gln Ile Leu Ile Glu Asn Ala Ala Gly His Arg 
            580                 585                 590         


Val Cys Ile Ser Thr Tyr Thr Thr Asn Leu Gly Ser Gly Pro Val Ser 
        595                 600                 605             


Ile Ser Ser Val Gly Val Leu Ala Pro His Ser Ala Leu Ala Ala Leu 
    610                 615                 620                 


Glu Asp Thr Val Asp Tyr Pro Ala Arg Ala His Thr Phe Asp Asp Phe 
625                 630                 635                 640 


Cys Pro Glu Cys Arg Thr Leu Gly Leu Gln Gly Cys Ala Phe Gln Ser 
                645                 650                 655     


Thr Val Ala Glu Leu Gln Arg Leu Lys Met Lys Val Gly Lys Thr Arg 
            660                 665                 670         


Glu Tyr 
        


<210>  4
<211>  674
<212>  PRT
<213>  Hepatitis E virus

<400>  4

Met Asn Asn Met Phe Phe Cys Ser Val His Gly Asp Ala Thr Met Arg 
1               5                   10                  15      


Ser Arg Ala Phe Leu Phe Leu Phe Leu Val Leu Leu Pro Met Leu Pro 
            20                  25                  30          


Ala Pro Pro Ala Gly Gln Pro Ser Gly Arg Arg Arg Gly Arg Arg Ser 
        35                  40                  45              


Gly Gly Ala Gly Gly Gly Phe Trp Gly Asp Arg Val Asp Ser Gln Pro 
    50                  55                  60                  


Phe Ala Leu Pro Tyr Ile His Pro Thr Asn Pro Phe Ala Ser Asp Ile 
65                  70                  75                  80  


Pro Ala Ala Ala Gly Ala Gly Ala Arg Pro Arg Gln Pro Ala Arg Pro 
                85                  90                  95      


Leu Gly Ser Ala Trp Arg Asp Gln Ser Gln Arg Pro Ala Thr Ser Ala 
            100                 105                 110         


Arg Arg Arg Ser Ala Pro Ala Gly Ala Ser Pro Leu Thr Ala Val Ala 
        115                 120                 125             


Pro Ala Pro Asp Thr Ala Pro Val Pro Asp Val Asp Ser Arg Gly Ala 
    130                 135                 140                 


Ile Leu Arg Arg Gln Tyr Asn Leu Ser Thr Ser Pro Leu Thr Ser Thr 
145                 150                 155                 160 


Ile Ala Thr Gly Thr Asn Leu Val Leu Tyr Ala Ala Pro Leu Ser Pro 
                165                 170                 175     


Leu Leu Pro Leu Gln Asp Gly Thr Asn Thr His Ile Met Ala Thr Glu 
            180                 185                 190         


Ala Ser Asn Tyr Ala Gln Tyr Arg Val Val Arg Ala Thr Ile Arg Tyr 
        195                 200                 205             


Arg Pro Leu Val Pro Asn Ala Val Gly Gly Tyr Ala Ile Ser Ile Ser 
    210                 215                 220                 


Phe Trp Pro Gln Thr Thr Thr Thr Pro Thr Ser Val Asp Met Asn Ser 
225                 230                 235                 240 


Ile Thr Ser Thr Asp Val Arg Ile Leu Val Gln Pro Gly Ile Ala Ser 
                245                 250                 255     


Glu Leu Val Ile Pro Ser Glu Arg Leu His Tyr Arg Asn Gln Gly Trp 
            260                 265                 270         


Arg Ser Val Glu Thr Ser Gly Val Ala Glu Glu Glu Ala Thr Ser Gly 
        275                 280                 285             


Leu Val Met Leu Cys Ile His Gly Ser Pro Val Asn Ser Tyr Thr Asn 
    290                 295                 300                 


Thr Pro Tyr Thr Gly Ala Leu Gly Leu Leu Asp Phe Ala Leu Glu Leu 
305                 310                 315                 320 


Glu Phe Arg Asn Leu Thr Pro Gly Asn Thr Asn Thr Arg Val Ser Arg 
                325                 330                 335     


Tyr Ser Ser Ser Ala Arg His Lys Leu Arg Arg Gly Pro Asp Gly Thr 
            340                 345                 350         


Ala Glu Leu Thr Thr Thr Ala Ala Thr Arg Phe Met Lys Asp Leu His 
        355                 360                 365             


Phe Thr Gly Thr Asn Gly Val Gly Glu Val Gly Arg Gly Ile Ala Leu 
    370                 375                 380                 


Thr Leu Phe Asn Leu Ala Asp Thr Leu Leu Gly Gly Leu Pro Thr Glu 
385                 390                 395                 400 


Leu Ile Ser Ser Ala Gly Gly Gln Leu Phe Tyr Ser Arg Pro Val Val 
                405                 410                 415     


Ser Ala Asn Gly Glu Pro Thr Val Lys Leu Tyr Thr Ser Val Glu Asn 
            420                 425                 430         


Ala Gln Gln Asp Lys Gly Ile Ala Ile Pro His Asp Ile Asp Leu Gly 
        435                 440                 445             


Glu Ser Arg Val Val Ile Gln Asp Tyr Asp Asn Gln His Glu Gln Asp 
    450                 455                 460                 


Arg Pro Thr Pro Ser Pro Ala Pro Ser Arg Pro Phe Ser Val Leu Arg 
465                 470                 475                 480 


Ala Asn Asp Val Leu Trp Leu Ser Leu Thr Ala Ala Glu Tyr Asp Gln 
                485                 490                 495     


Thr Thr Tyr Gly Ser Ser Thr Asn Pro Met Tyr Val Ser Asp Thr Val 
            500                 505                 510         


Thr Phe Val Asn Val Ala Thr Gly Ala Gln Gly Val Ser Arg Ser Leu 
        515                 520                 525             


Asp Trp Ser Lys Val Thr Leu Asp Gly Arg Pro Leu Met Thr Ile Gln 
    530                 535                 540                 


Gln Tyr Ser Lys Thr Phe Phe Val Leu Pro Leu Arg Gly Lys Leu Ser 
545                 550                 555                 560 


Phe Trp Glu Ala Gly Thr Thr Lys Ala Gly Tyr Pro Tyr Asn Tyr Asn 
                565                 570                 575     


Thr Thr Ala Ser Asp Gln Ile Leu Ile Glu Asn Ala Ala Gly His Arg 
            580                 585                 590         


Val Cys Ile Ser Thr Tyr Thr Thr Asn Leu Gly Ser Gly Pro Val Ser 
        595                 600                 605             


Ile Ser Ala Val Gly Val Leu Ala Pro His Ser Ala Leu Ala Ala Leu 
    610                 615                 620                 


Glu Asp Thr Val Asp Tyr Pro Ala Arg Ala His Thr Phe Asp Asp Phe 
625                 630                 635                 640 


Cys Pro Glu Cys Arg Thr Leu Gly Leu Gln Gly Cys Ala Phe Gln Ser 
                645                 650                 655     


Thr Val Ala Glu Leu Gln Arg Leu Lys Met Lys Val Gly Lys Thr Arg 
            660                 665                 670         


Glu Tyr 
        


<210>  5
<211>  674
<212>  PRT
<213>  Hepatitis E virus

<400>  5

Met Asn Asn Met Phe Phe Cys Ser Val His Gly Asp Ala Thr Met Arg 
1               5                   10                  15      


Ser Arg Ala Phe Leu Phe Leu Phe Leu Val Leu Leu Pro Met Leu Pro 
            20                  25                  30          


Ala Pro Pro Ala Gly Gln Pro Ser Gly Arg Arg Arg Gly Arg Arg Ser 
        35                  40                  45              


Gly Gly Ala Gly Gly Gly Phe Trp Gly Asp Arg Val Asp Ser Gln Pro 
    50                  55                  60                  


Phe Ala Leu Pro Tyr Ile His Pro Thr Asn Pro Phe Ala Ser Asp Ile 
65                  70                  75                  80  


Pro Ala Ala Ala Gly Ala Gly Ala Arg Pro Arg Gln Pro Ala Arg Pro 
                85                  90                  95      


Leu Gly Ser Ala Trp Arg Asp Gln Ser Gln Arg Pro Ala Thr Ser Ala 
            100                 105                 110         


Arg Arg Arg Ser Ala Pro Ala Gly Ala Ser Pro Leu Thr Ala Val Ala 
        115                 120                 125             


Pro Ala Pro Asp Thr Ala Pro Val Pro Asp Val Asp Ser Arg Gly Ala 
    130                 135                 140                 


Ile Leu Arg Arg Gln Tyr Asn Leu Ser Thr Ser Pro Leu Thr Ser Thr 
145                 150                 155                 160 


Ile Ala Thr Gly Thr Asn Leu Val Leu Tyr Ala Ala Pro Leu Ser Pro 
                165                 170                 175     


Leu Leu Pro Leu Gln Asp Gly Thr Asn Thr His Ile Met Ala Thr Glu 
            180                 185                 190         


Ala Ser Asn Tyr Ala Gln Tyr Arg Val Val Arg Ala Thr Ile Arg Tyr 
        195                 200                 205             


Arg Pro Leu Val Pro Asn Ala Val Gly Gly Tyr Ala Ile Ser Ile Ser 
    210                 215                 220                 


Phe Trp Pro Gln Thr Thr Thr Thr Pro Thr Ser Val Asp Met Asn Ser 
225                 230                 235                 240 


Ile Thr Ser Thr Asp Val Arg Ile Leu Val Gln Pro Gly Val Ala Ser 
                245                 250                 255     


Glu Leu Val Ile Pro Ser Glu Arg Leu His Tyr Arg Asn Gln Gly Trp 
            260                 265                 270         


Arg Ser Val Glu Thr Ser Gly Val Ala Glu Glu Glu Ala Thr Ser Gly 
        275                 280                 285             


Leu Val Met Leu Cys Ile His Gly Ser Pro Val Asn Ser Tyr Thr Asn 
    290                 295                 300                 


Thr Pro Tyr Thr Gly Ala Leu Gly Leu Leu Asp Phe Ala Leu Glu Leu 
305                 310                 315                 320 


Glu Phe Arg Asn Leu Thr Pro Gly Asn Thr Asn Thr Arg Val Ser Arg 
                325                 330                 335     


Tyr Ser Ser Ser Ala Arg His Lys Leu Arg Arg Gly Pro Asp Gly Thr 
            340                 345                 350         


Ala Glu Leu Thr Thr Thr Ala Ala Thr Arg Phe Met Lys Asp Leu His 
        355                 360                 365             


Phe Thr Gly Thr Asn Gly Val Gly Glu Val Gly Arg Gly Ile Ala Leu 
    370                 375                 380                 


Thr Leu Phe Asn Leu Ala Asp Thr Leu Leu Gly Gly Leu Pro Thr Glu 
385                 390                 395                 400 


Leu Ile Ser Ser Ala Gly Gly Gln Leu Phe Tyr Ser Arg Pro Val Val 
                405                 410                 415     


Ser Ala Asn Gly Glu Pro Thr Val Lys Leu Tyr Thr Ser Val Glu Asn 
            420                 425                 430         


Ala Gln Gln Asp Lys Gly Ile Ala Ile Pro His Asp Ile Asp Leu Gly 
        435                 440                 445             


Glu Ser Arg Val Val Ile Gln Asp Tyr Asp Asn Gln His Glu Gln Asp 
    450                 455                 460                 


Arg Pro Thr Pro Ser Pro Ala Pro Ser Arg Pro Phe Ser Val Leu Arg 
465                 470                 475                 480 


Ala Asn Asp Val Leu Trp Leu Ser Leu Thr Ala Ala Glu Tyr Asp Gln 
                485                 490                 495     


Thr Thr Tyr Gly Ser Ser Thr Asn Pro Met Tyr Val Ser Asp Thr Val 
            500                 505                 510         


Thr Phe Val Asn Val Ala Thr Gly Ala Gln Gly Val Ser Arg Ser Leu 
        515                 520                 525             


Asp Trp Ser Lys Val Thr Leu Asp Gly Arg Pro Leu Met Thr Ile Gln 
    530                 535                 540                 


Gln Tyr Ser Lys Thr Phe Phe Val Leu Pro Leu Arg Gly Lys Leu Ser 
545                 550                 555                 560 


Phe Trp Glu Ala Gly Thr Thr Lys Ala Gly Tyr Pro Tyr Asn Tyr Asn 
                565                 570                 575     


Thr Thr Ala Ser Asp Gln Ile Leu Ile Glu Asn Ala Ala Gly His Arg 
            580                 585                 590         


Val Cys Ile Ser Thr Tyr Thr Thr Asn Leu Gly Ser Gly Pro Val Ser 
        595                 600                 605             


Ile Ser Ala Val Gly Val Leu Ala Pro His Ser Ala Leu Ala Ala Leu 
    610                 615                 620                 


Glu Asp Thr Val Asp Tyr Pro Ala Arg Ala His Thr Phe Asp Asp Phe 
625                 630                 635                 640 


Cys Pro Glu Cys Arg Ala Leu Gly Leu Gln Gly Cys Ala Phe Gln Ser 
                645                 650                 655     


Thr Val Ala Glu Leu Gln Arg Leu Lys Met Lys Val Gly Lys Thr Arg 
            660                 665                 670         


Glu Tyr 
        


<210>  6
<211>  674
<212>  PRT
<213>  Hepatitis E virus

<400>  6

Met Asn Asn Met Phe Phe Cys Ser Leu His Gly Asp Ala Thr Met Arg 
1               5                   10                  15      


Ser Arg Ala Leu Leu Phe Leu Leu Leu Leu Leu Leu Pro Met Leu Pro 
            20                  25                  30          


Ala Pro Pro Ala Gly Gln Pro Ser Gly Arg Arg Arg Gly Arg Arg Ser 
        35                  40                  45              


Gly Gly Ala Gly Ser Gly Phe Trp Gly Asp Arg Val Asp Ser Gln Pro 
    50                  55                  60                  


Phe Ala Leu Pro Tyr Ile His Pro Thr Asn Pro Phe Ala Ser Asp Ile 
65                  70                  75                  80  


Pro Ala Ala Ala Gly Ala Gly Ala Arg Pro Arg Gln Pro Ala Arg Pro 
                85                  90                  95      


Leu Gly Ser Ala Trp Arg Asp Gln Ser Gln Arg Pro Ala Ala Pro Ala 
            100                 105                 110         


Arg Arg Arg Ser Ala Pro Ala Gly Ala Ser Pro Leu Thr Ala Val Ala 
        115                 120                 125             


Pro Ala Pro Asp Thr Ala Pro Val Pro Asp Val Asp Ser Arg Gly Ala 
    130                 135                 140                 


Ile Leu Arg Arg Gln Tyr Asn Leu Ser Thr Ser Pro Leu Thr Ser Thr 
145                 150                 155                 160 


Ile Ala Thr Gly Thr Asn Leu Val Leu Tyr Ala Ala Pro Leu Ser Pro 
                165                 170                 175     


Leu Leu Pro Leu Gln Asp Gly Thr Asn Thr His Ile Met Ala Thr Glu 
            180                 185                 190         


Ala Ser Asn Tyr Ala Gln Tyr Arg Val Val Arg Ala Thr Ile Arg Tyr 
        195                 200                 205             


Arg Pro Leu Val Pro Asn Ala Val Gly Gly Tyr Ala Ile Ser Ile Ser 
    210                 215                 220                 


Phe Trp Pro Gln Thr Thr Thr Thr Pro Thr Ser Val Asp Met Asn Ser 
225                 230                 235                 240 


Ile Thr Ser Thr Asp Val Arg Ile Leu Val Gln Pro Gly Ile Ala Ser 
                245                 250                 255     


Glu Leu Val Ile Pro Ser Glu Arg Leu His Tyr Arg Asn Gln Gly Trp 
            260                 265                 270         


Arg Ser Val Glu Thr Ser Gly Val Ala Glu Glu Glu Ala Thr Ser Gly 
        275                 280                 285             


Leu Val Met Leu Cys Ile His Gly Ser Pro Val Asn Ser Tyr Thr Asn 
    290                 295                 300                 


Thr Pro Tyr Thr Gly Ala Leu Gly Leu Leu Asp Phe Ala Leu Glu Leu 
305                 310                 315                 320 


Glu Phe Arg Asn Leu Thr Pro Gly Asn Thr Asn Thr Arg Val Ser Arg 
                325                 330                 335     


Tyr Ser Ser Ser Ala Arg His Lys Leu Arg Arg Gly Ala Asp Gly Thr 
            340                 345                 350         


Ala Glu Leu Thr Thr Thr Ala Ala Thr Arg Phe Met Lys Asp Leu His 
        355                 360                 365             


Phe Thr Gly Thr Asn Gly Val Gly Glu Val Gly Arg Gly Ile Ala Leu 
    370                 375                 380                 


Thr Leu Phe Asn Leu Ala Asp Thr Leu Leu Gly Gly Leu Pro Thr Glu 
385                 390                 395                 400 


Leu Ile Ser Ser Ala Gly Gly Gln Leu Phe Tyr Ser Arg Pro Val Val 
                405                 410                 415     


Ser Ala Asn Gly Glu Pro Thr Val Lys Leu Tyr Thr Ser Val Glu Asn 
            420                 425                 430         


Ala Gln Gln Asp Lys Gly Ile Ala Ile Pro His Asp Ile Asp Leu Gly 
        435                 440                 445             


Glu Ser Arg Val Val Ile Gln Asp Tyr Asp Asn Gln His Glu Gln Asp 
    450                 455                 460                 


Arg Pro Thr Pro Ser Pro Ala Pro Ser Arg Pro Phe Ser Val Leu Arg 
465                 470                 475                 480 


Ala Asn Asp Val Leu Trp Leu Ser Leu Thr Ala Ala Glu Tyr Asp Gln 
                485                 490                 495     


Thr Thr Tyr Gly Ser Ser Thr Asn Pro Met Tyr Val Ser Asp Thr Val 
            500                 505                 510         


Thr Phe Val Asn Val Ala Thr Gly Ala Gln Gly Val Ser Arg Ser Leu 
        515                 520                 525             


Asp Trp Ser Lys Val Thr Leu Asp Gly Arg Pro Leu Thr Thr Ile Gln 
    530                 535                 540                 


Gln Tyr Ser Lys Thr Phe Tyr Val Leu Pro Leu Arg Gly Lys Leu Ser 
545                 550                 555                 560 


Phe Trp Glu Ala Gly Thr Thr Lys Ala Gly Tyr Pro Tyr Asn Tyr Asn 
                565                 570                 575     


Thr Thr Ala Ser Asp Gln Ile Leu Ile Glu Asn Ala Ala Gly His Arg 
            580                 585                 590         


Val Cys Ile Ser Thr Tyr Thr Thr Asn Leu Gly Ser Gly Pro Val Ser 
        595                 600                 605             


Ile Ser Ala Val Gly Val Leu Ala Pro His Ser Ala Leu Ala Val Leu 
    610                 615                 620                 


Glu Asp Thr Val Asp Tyr Pro Ala Arg Ala His Thr Phe Asp Asp Phe 
625                 630                 635                 640 


Cys Pro Glu Cys Arg Ala Leu Gly Leu Gln Gly Cys Ala Phe Gln Ser 
                645                 650                 655     


Thr Val Ala Glu Leu Gln Arg Leu Lys Met Lys Val Gly Lys Thr Arg 
            660                 665                 670         


Glu Tyr 
        


<210>  7
<211>  674
<212>  PRT
<213>  Hepatitis E virus

<400>  7

Met Asn Asn Met Phe Phe Cys Ser Ala His Gly Asp Ala Thr Met Arg 
1               5                   10                  15      


Ser Arg Ala Leu Leu Phe Leu Leu Leu Val Phe Leu Pro Met Leu Pro 
            20                  25                  30          


Ala Pro Pro Ala Gly Gln Pro Ser Gly Arg Arg Arg Gly Arg Arg Ser 
        35                  40                  45              


Gly Gly Ala Gly Ser Gly Phe Trp Gly Asp Arg Val Asp Ser Gln Pro 
    50                  55                  60                  


Phe Ala Leu Pro Tyr Ile His Pro Thr Asn Pro Phe Ala Ser Asp Ile 
65                  70                  75                  80  


Pro Ala Ala Ala Gly Ala Gly Ala Arg Pro Arg Gln Pro Ala Arg Pro 
                85                  90                  95      


Leu Gly Ser Ala Trp Arg Asp Gln Ser Gln Arg Pro Ala Ala Ser Thr 
            100                 105                 110         


Arg Arg Arg Pro Ala Pro Ala Gly Ala Ser Pro Leu Thr Ala Val Ala 
        115                 120                 125             


Pro Ala Pro Asp Thr Ala Pro Val Pro Asp Val Asp Ser Arg Gly Ala 
    130                 135                 140                 


Ile Leu Arg Arg Gln Tyr Asn Leu Ser Thr Ser Pro Leu Thr Ser Thr 
145                 150                 155                 160 


Ile Ala Thr Gly Thr Asn Leu Val Leu Tyr Ala Ala Pro Leu Ser Pro 
                165                 170                 175     


Leu Leu Pro Leu Gln Asp Gly Thr Asn Thr His Ile Met Ala Thr Glu 
            180                 185                 190         


Ala Ser Asn Tyr Ala Gln Tyr Arg Val Val Arg Ala Thr Ile Arg Tyr 
        195                 200                 205             


Arg Pro Leu Val Pro Asn Ala Val Gly Gly Tyr Ala Ile Ser Ile Ser 
    210                 215                 220                 


Phe Trp Pro Gln Thr Thr Thr Thr Pro Thr Ser Val Asp Met Asn Ser 
225                 230                 235                 240 


Ile Thr Ser Thr Asp Val Arg Ile Leu Val Gln Pro Gly Ile Ala Ser 
                245                 250                 255     


Glu Leu Val Ile Pro Ser Glu Arg Leu His Tyr Arg Asn Gln Gly Trp 
            260                 265                 270         


Arg Ser Val Glu Thr Ser Gly Val Ala Glu Glu Glu Ala Thr Ser Gly 
        275                 280                 285             


Leu Val Met Leu Cys Ile His Gly Ser Pro Val Asn Ser Tyr Thr Asn 
    290                 295                 300                 


Thr Pro Tyr Thr Gly Ala Leu Gly Leu Leu Asp Phe Ala Leu Glu Leu 
305                 310                 315                 320 


Glu Phe Arg Asn Leu Thr Pro Gly Asn Thr Asn Thr Arg Val Ser Arg 
                325                 330                 335     


Tyr Ser Ser Ser Ala Arg His Lys Leu Arg Arg Gly Pro Asp Gly Thr 
            340                 345                 350         


Val Glu Leu Thr Thr Thr Ala Ala Thr Arg Phe Met Lys Asp Leu His 
        355                 360                 365             


Phe Thr Gly Thr Asn Gly Val Gly Glu Val Gly Arg Gly Ile Ala Leu 
    370                 375                 380                 


Thr Leu Phe Asn Leu Ala Asp Thr Leu Leu Gly Gly Leu Pro Thr Glu 
385                 390                 395                 400 


Leu Ile Ser Ser Ala Gly Gly Gln Leu Phe Tyr Ser Arg Pro Val Val 
                405                 410                 415     


Ser Ala Asn Gly Glu Pro Thr Val Lys Leu Tyr Thr Ser Val Glu Asn 
            420                 425                 430         


Ala Gln Gln Asp Lys Gly Ile Ala Ile Pro His Asp Ile Asp Leu Gly 
        435                 440                 445             


Glu Ser Arg Val Val Ile Gln Asp Tyr Asp Asn Gln His Glu Gln Asp 
    450                 455                 460                 


Arg Pro Thr Pro Ser Pro Ala Pro Ser Arg Pro Phe Ser Val Leu Arg 
465                 470                 475                 480 


Ala Asn Asp Val Leu Trp Leu Ser Leu Thr Ala Ala Glu Tyr Asp Gln 
                485                 490                 495     


Thr Thr Tyr Gly Ser Ser Thr Asn Pro Met Tyr Val Ser Asp Thr Val 
            500                 505                 510         


Thr Phe Val Asn Val Ala Thr Gly Ala Gln Gly Val Ser Arg Ser Leu 
        515                 520                 525             


Asp Trp Ser Lys Val Thr Leu Asp Gly Arg Pro Leu Thr Thr Ile Gln 
    530                 535                 540                 


Gln Tyr Ser Lys Thr Phe Tyr Val Leu Pro Leu Arg Gly Lys Leu Ser 
545                 550                 555                 560 


Phe Trp Glu Ala Gly Thr Thr Lys Ala Gly Tyr Pro Tyr Asn Tyr Asn 
                565                 570                 575     


Thr Thr Ala Ser Asp Gln Ile Leu Ile Glu Asn Ala Ala Gly His Arg 
            580                 585                 590         


Val Cys Ile Ser Thr Tyr Thr Thr Asn Leu Gly Ser Gly Pro Val Ser 
        595                 600                 605             


Ile Ser Ala Val Gly Val Leu Ala Pro His Ser Ala Leu Ala Ile Leu 
    610                 615                 620                 


Glu Asp Thr Ala Asp Tyr Pro Ala Arg Ala His Thr Phe Asp Asp Phe 
625                 630                 635                 640 


Cys Pro Glu Cys Arg Ser Leu Gly Leu Gln Gly Cys Ala Phe Gln Ser 
                645                 650                 655     


Thr Val Ala Glu Leu Gln Arg Leu Lys Met Lys Val Gly Lys Thr Arg 
            660                 665                 670         


Glu Tyr 
        


<210>  8
<211>  672
<212>  PRT
<213>  Hepatitis E virus

<400>  8

Met Asn Asn Met Phe Phe Cys Ser Val His Gly Asp Ala Thr Met Arg 
1               5                   10                  15      


Ser Arg Ala Leu Leu Phe Leu Leu Phe Val Leu Leu Pro Met Leu Pro 
            20                  25                  30          


Ala Pro Pro Ala Gly Gln Pro Ser Gly Arg Arg Arg Gly Gln Ala Gly 
        35                  40                  45              


Cys Gly Gly Gly Phe Trp Gly Asp Arg Val Asp Ser Gln Pro Phe Ala 
    50                  55                  60                  


Leu Pro Tyr Ile His Pro Thr Asn Pro Phe Ala Ser Asp Ile Pro Ala 
65                  70                  75                  80  


Ala Ala Gly Thr Gly Ala Arg Pro Arg Gln Pro Ile Arg Pro Leu Gly 
                85                  90                  95      


Ser Ala Trp Arg Asp Gln Ser Gln Arg Pro Ala Ala Ser Thr Arg Arg 
            100                 105                 110         


Arg Pro Ala Pro Ala Gly Ala Ser Pro Leu Thr Ala Val Ala Pro Ala 
        115                 120                 125             


Pro Asp Thr Ala Pro Val Pro Asp Ala Asp Ser Arg Gly Ala Ile Leu 
    130                 135                 140                 


Arg Arg Gln Tyr Asn Leu Ser Thr Ser Pro Leu Thr Ser Thr Ile Ala 
145                 150                 155                 160 


Thr Gly Thr Asn Phe Val Leu Tyr Ala Ala Pro Leu Ser Pro Leu Leu 
                165                 170                 175     


Pro Leu Gln Asp Gly Thr Asn Thr His Ile Met Ala Thr Glu Ala Ser 
            180                 185                 190         


Asn Tyr Ala Gln Tyr Arg Val Val Arg Ala Thr Ile Arg Tyr Arg Pro 
        195                 200                 205             


Leu Val Pro Asn Ala Val Gly Gly Tyr Ala Ile Ser Ile Ser Phe Trp 
    210                 215                 220                 


Pro Gln Thr Thr Thr Thr Pro Thr Ser Val Asp Met Asn Ser Ile Thr 
225                 230                 235                 240 


Ser Thr Asp Val Arg Ile Leu Val Gln Pro Gly Ile Ala Ser Glu Leu 
                245                 250                 255     


Val Thr Pro Ser Glu Arg Leu His Tyr Arg Asn Gln Gly Trp Arg Ser 
            260                 265                 270         


Val Glu Thr Ser Gly Val Ala Glu Glu Glu Ala Thr Ser Gly Leu Val 
        275                 280                 285             


Met Leu Cys Ile His Gly Ser Pro Val Asn Ser Tyr Thr Asn Thr Pro 
    290                 295                 300                 


Tyr Thr Gly Ala Leu Gly Leu Leu Asp Phe Ala Leu Glu Leu Glu Phe 
305                 310                 315                 320 


Arg Asn Leu Thr Pro Gly Asn Thr Asn Thr Arg Val Ser Arg Tyr Ser 
                325                 330                 335     


Ser Ser Ala Arg His Lys Leu Arg Arg Gly Pro Asp Gly Thr Ala Glu 
            340                 345                 350         


Leu Thr Thr Thr Ala Ala Thr Arg Phe Met Lys Asp Leu His Phe Thr 
        355                 360                 365             


Gly Thr Asn Gly Val Gly Glu Val Gly Arg Gly Ile Ala Leu Thr Leu 
    370                 375                 380                 


Phe Asn Leu Ala Asp Thr Leu Leu Gly Gly Leu Pro Thr Glu Leu Ile 
385                 390                 395                 400 


Ser Ser Ala Gly Gly Gln Leu Phe Tyr Ser Arg Pro Val Val Ser Ala 
                405                 410                 415     


Asn Gly Glu Leu Thr Val Lys Leu Tyr Thr Ser Val Glu Asn Ala Gln 
            420                 425                 430         


Gln Asp Lys Gly Val Ala Ile Pro His Asp Ile Asp Leu Gly Glu Ser 
        435                 440                 445             


Arg Val Val Ile Gln Asp Tyr Asp Asn Gln His Glu Gln Asp Arg Pro 
    450                 455                 460                 


Thr Pro Ser Pro Ala Pro Ser Arg Pro Phe Ser Val Leu Arg Ala Asn 
465                 470                 475                 480 


Asp Val Leu Trp Leu Ser Leu Thr Ala Ala Glu Tyr Asp Gln Thr Thr 
                485                 490                 495     


Tyr Gly Ser Ser Thr Asn Pro Met Tyr Val Ser Asp Thr Val Thr Phe 
            500                 505                 510         


Val Asn Val Ala Thr Gly Ala Gln Gly Val Ser Arg Ser Leu Asp Trp 
        515                 520                 525             


Ser Lys Val Thr Leu Asp Gly Arg Pro Leu Thr Thr Ile Gln Gln Tyr 
    530                 535                 540                 


Ser Lys Thr Phe Tyr Val Leu Pro Leu Arg Gly Lys Leu Ser Phe Trp 
545                 550                 555                 560 


Glu Ala Gly Thr Thr Lys Ala Gly Tyr Pro Tyr Asn Tyr Asn Thr Thr 
                565                 570                 575     


Ala Ser Asp Gln Ile Leu Ile Glu Asn Ala Ala Gly His Arg Val Cys 
            580                 585                 590         


Ile Ser Thr Tyr Thr Thr Asn Leu Gly Ser Gly Pro Val Ser Val Ser 
        595                 600                 605             


Ala Val Gly Val Leu Ala Pro His Ser Ala Leu Ala Ala Leu Glu Asp 
    610                 615                 620                 


Thr Ala Asp Tyr Pro Ala Arg Ala His Thr Phe Asp Asp Phe Cys Pro 
625                 630                 635                 640 


Glu Cys Arg Ala Leu Gly Leu Gln Gly Cys Ala Phe Gln Ser Thr Val 
                645                 650                 655     


Gly Glu Leu Gln Arg Leu Lys Met Lys Val Gly Lys Thr Arg Glu Tyr 
            660                 665                 670         


<210>  9
<211>  671
<212>  PRT
<213>  Hepatitis E virus

<400>  9

Met Phe Phe Cys Ser Val His Gly Asp Ala Thr Met Arg Ser Arg Ala 
1               5                   10                  15      


Leu Leu Phe Leu Leu Phe Val Leu Leu Pro Met Leu Pro Ala Pro Pro 
            20                  25                  30          


Ala Gly Gln Pro Ser Gly Arg Arg Arg Gly Arg Arg Ser Gly Gly Ala 
        35                  40                  45              


Gly Gly Gly Phe Trp Gly Asp Arg Val Asp Ser Gln Pro Phe Ala Leu 
    50                  55                  60                  


Pro Tyr Ile His Pro Thr Asn Pro Phe Ala Ser Asp Ile Pro Thr Ala 
65                  70                  75                  80  


Ala Gly Ser Gly Ala Arg Pro Arg Gln Pro Val Arg Pro Leu Gly Ser 
                85                  90                  95      


Ala Trp Arg Asp Gln Ser Gln Arg Pro Ala Ala Ser Ala Arg Arg Arg 
            100                 105                 110         


Pro Ala Pro Ala Gly Ala Ser Pro Leu Thr Ala Val Ala Pro Ala Pro 
        115                 120                 125             


Asp Thr Ala Pro Val Pro Asp Val Asp Ser Arg Gly Ala Ile Leu Arg 
    130                 135                 140                 


Arg Gln Tyr Asn Leu Ser Thr Ser Pro Leu Thr Ser Thr Ile Ala Thr 
145                 150                 155                 160 


Gly Thr Asn Leu Val Leu Tyr Ala Ala Pro Leu Ser Pro Leu Leu Pro 
                165                 170                 175     


Leu Gln Asp Gly Thr Asn Thr His Ile Met Ala Thr Glu Ala Ser Asn 
            180                 185                 190         


Tyr Ala Gln Tyr Arg Val Val Arg Ala Thr Ile Arg Tyr Arg Pro Leu 
        195                 200                 205             


Val Pro Asn Ala Val Gly Gly Tyr Ala Ile Ser Ile Ser Phe Trp Pro 
    210                 215                 220                 


Gln Thr Thr Thr Thr Pro Thr Ser Val Asp Met Asn Ser Ile Thr Ser 
225                 230                 235                 240 


Thr Asp Val Arg Ile Leu Val Gln Pro Gly Ile Ala Ser Glu Leu Val 
                245                 250                 255     


Ile Pro Ser Glu Arg Leu His Tyr Arg Asn Gln Gly Trp Arg Ser Val 
            260                 265                 270         


Glu Thr Ser Gly Val Ala Glu Glu Glu Ala Thr Ser Gly Leu Val Met 
        275                 280                 285             


Leu Cys Ile His Gly Ser Pro Val Asn Ser Tyr Thr Asn Thr Pro Tyr 
    290                 295                 300                 


Thr Gly Ala Leu Gly Leu Leu Asp Phe Ala Leu Glu Leu Glu Phe Arg 
305                 310                 315                 320 


Asn Leu Thr Pro Gly Asn Thr Asn Thr Arg Val Ser Arg Tyr Ser Ser 
                325                 330                 335     


Ser Ala Arg His Lys Leu Arg Arg Gly Pro Asp Gly Thr Ala Glu Leu 
            340                 345                 350         


Thr Thr Thr Ala Ala Thr Arg Phe Met Lys Asp Leu His Phe Thr Gly 
        355                 360                 365             


Thr Asn Gly Val Gly Glu Val Gly Arg Gly Ile Ala Leu Thr Leu Phe 
    370                 375                 380                 


Asn Leu Ala Asp Thr Leu Leu Gly Gly Leu Pro Thr Glu Leu Ile Ser 
385                 390                 395                 400 


Ser Ala Gly Gly Gln Leu Phe Tyr Ser Arg Pro Val Val Ser Ala Asn 
                405                 410                 415     


Gly Glu Pro Thr Val Lys Leu Tyr Thr Ser Val Glu Asn Ala Gln Gln 
            420                 425                 430         


Asp Lys Gly Ile Ala Ile Pro His Asp Ile Asp Leu Gly Glu Ser Arg 
        435                 440                 445             


Val Val Ile Gln Asp Tyr Asp Asn Gln His Glu Gln Asp Arg Pro Thr 
    450                 455                 460                 


Pro Ser Pro Ala Pro Ser Arg Pro Phe Ser Val Leu Arg Ala Asn Asp 
465                 470                 475                 480 


Val Leu Trp Leu Ser Leu Thr Ala Ala Glu Tyr Asp Gln Thr Thr Tyr 
                485                 490                 495     


Gly Ser Ser Thr Asn Pro Met Tyr Val Ser Asp Thr Val Thr Phe Val 
            500                 505                 510         


Asn Val Ala Thr Gly Ala Gln Gly Val Ser Arg Ser Leu Asp Trp Ser 
        515                 520                 525             


Lys Val Thr Leu Asp Gly Arg Pro Leu Thr Thr Ile Gln Gln Tyr Ser 
    530                 535                 540                 


Lys Thr Phe Phe Val Leu Pro Leu Arg Gly Lys Leu Ser Phe Trp Glu 
545                 550                 555                 560 


Ala Gly Thr Thr Lys Ala Gly Tyr Pro Tyr Asn Tyr Asn Thr Thr Ala 
                565                 570                 575     


Ser Asp Gln Ile Leu Ile Glu Asn Ala Ala Gly His Arg Val Cys Ile 
            580                 585                 590         


Ser Thr Tyr Thr Thr Asn Leu Gly Ser Gly Pro Val Ser Ile Ser Ala 
        595                 600                 605             


Val Gly Val Leu Ala Pro His Ser Ala Leu Ala Ala Leu Glu Asp Thr 
    610                 615                 620                 


Val Asp Tyr Pro Ala Arg Ala His Thr Phe Asp Asp Phe Cys Pro Glu 
625                 630                 635                 640 


Cys Arg Thr Leu Gly Leu Gln Gly Cys Ala Phe Gln Ser Thr Val Ala 
                645                 650                 655     


Glu Leu Gln Arg Leu Lys Met Lys Val Gly Lys Thr Arg Glu Tyr 
            660                 665                 670     


<210>  10
<211>  668
<212>  PRT
<213>  Hepatitis E virus

<400>  10

Met Phe Phe Cys Ser Val His Gly Asp Ala Thr Met Arg Ser Arg Ala 
1               5                   10                  15      


Leu Leu Phe Leu Leu Leu Val Phe Leu Pro Met Leu Pro Ala Leu Pro 
            20                  25                  30          


Ala Gly Gln Pro Ser Gly Arg Arg Arg Gly Arg Arg Ser Gly Ser Ala 
        35                  40                  45              


Gly Gly Gly Phe Trp Gly Asp Arg Val Asp Ser Gln Pro Phe Ala Leu 
    50                  55                  60                  


Pro Tyr Ile His Pro Thr Asn Pro Phe Ala Ser Asp Ile Pro Thr Ala 
65                  70                  75                  80  


Ala Gly Ala Gly Ala Arg Pro Arg Gln Pro Ala Arg Pro Leu Gly Ser 
                85                  90                  95      


Ala Trp Arg Asp Gln Ser Gln Arg Pro Ala Thr Ser Thr Arg Arg Arg 
            100                 105                 110         


Ser Ala Pro Val Gly Ala Ser Pro Leu Thr Ala Val Ala Pro Ala Pro 
        115                 120                 125             


Asp Thr Ala Pro Val Pro Asp Val Asp Ser Arg Gly Ala Ile Leu Arg 
    130                 135                 140                 


Arg Gln Tyr Asn Leu Ser Thr Ser Pro Leu Thr Ser Thr Ile Ala Thr 
145                 150                 155                 160 


Gly Thr Asn Leu Val Leu Tyr Ala Ala Pro Leu Ser Pro Leu Leu Pro 
                165                 170                 175     


Leu Gln Asp Gly Thr Asn Thr His Ile Met Ala Thr Glu Ala Ser Asn 
            180                 185                 190         


Tyr Ala Gln Tyr Arg Val Val Arg Ala Thr Ile Arg Tyr Arg Pro Leu 
        195                 200                 205             


Val Pro Asn Ala Val Gly Gly Tyr Ala Ile Ser Ile Ser Phe Trp Pro 
    210                 215                 220                 


Gln Thr Thr Thr Thr Pro Thr Ser Val Asp Met Asn Ser Ile Thr Ser 
225                 230                 235                 240 


Thr Asp Val Arg Ile Leu Val Gln Ser Gly Ile Ala Ser Glu Leu Val 
                245                 250                 255     


Ile Pro Ser Glu Arg Leu His Tyr Arg Asn Gln Gly Trp Arg Ser Val 
            260                 265                 270         


Glu Thr Ser Gly Val Ala Glu Glu Glu Ala Thr Ser Gly Leu Val Met 
        275                 280                 285             


Leu Cys Ile His Gly Ser Pro Val Asn Ser Tyr Thr Asn Thr Pro Tyr 
    290                 295                 300                 


Thr Gly Ala Leu Gly Leu Leu Asp Phe Ala Leu Glu Leu Glu Phe Arg 
305                 310                 315                 320 


Asn Leu Thr Pro Gly Asn Thr Asn Met Arg Val Ser Arg His Ser Ser 
                325                 330                 335     


Ser Ala Arg His Lys Leu Arg Arg Gly Pro Asp Gly Thr Ala Glu Leu 
            340                 345                 350         


Thr Thr Thr Ala Ala Thr Arg Phe Met Lys Asp Leu His Phe Thr Gly 
        355                 360                 365             


Thr Asn Gly Val Gly Glu Val Gly Arg Gly Ile Ala Leu Thr Leu Phe 
    370                 375                 380                 


Asn Leu Ala Asp Thr Leu Leu Gly Gly Leu Pro Thr Glu Leu Ile Ser 
385                 390                 395                 400 


Ser Ala Gly Gly Gln Leu Phe Tyr Ser Arg Pro Val Val Ser Ala Asn 
                405                 410                 415     


Gly Glu Pro Thr Val Lys Leu Tyr Thr Ser Val Glu Asn Ala Gln Gln 
            420                 425                 430         


Asp Lys Gly Ile Ala Ile Pro His Asp Ile Asp Leu Gly Glu Ser Arg 
        435                 440                 445             


Val Gly Ile Gln Asp Tyr Asp Asn Gln His Glu Gln Asp Arg Pro Thr 
    450                 455                 460                 


Pro Ser Pro Ala Pro Ser Arg Pro Phe Ser Val Leu Arg Ala Asn Asp 
465                 470                 475                 480 


Val Leu Trp Leu Ser Leu Thr Ala Ala Glu Tyr Asp Gln Thr Thr Tyr 
                485                 490                 495     


Gly Ser Ser Thr Asn Pro Met Tyr Val Ser Asp Thr Val Thr Phe Val 
            500                 505                 510         


Asn Val Ala Thr Gly Ala Gln Gly Val Ser Arg Ser Leu Asp Trp Ser 
        515                 520                 525             


Lys Val Thr Leu Asp Gly Arg Ser Leu Thr Thr Ile Gln Gln Tyr Ser 
    530                 535                 540                 


Lys Thr Phe Phe Val Leu Pro Leu Arg Gly Lys Leu Ser Phe Trp Glu 
545                 550                 555                 560 


Ala Gly Thr Thr Lys Ala Gly Tyr Pro Tyr Asn Tyr Asn Thr Thr Ala 
                565                 570                 575     


Ser Asp Gln Ile Leu Ile Glu Asn Ala Ala Gly His Arg Val Cys Ile 
            580                 585                 590         


Ser Thr Tyr Thr Thr Asn Leu Gly Ser Gly Pro Val Ser Ile Ser Ala 
        595                 600                 605             


Val Gly Val Leu Ala Pro His Ser Ala Leu Ala Val Leu Glu Asp Thr 
    610                 615                 620                 


Val Asp Tyr Pro Ala Arg Ala His Thr Phe Asp Asp Phe Cys Pro Glu 
625                 630                 635                 640 


Cys Arg Ala Leu Gly Leu Gln Gly Cys Ala Phe Gln Ser Thr Val Ala 
                645                 650                 655     


Glu Leu Gln Arg Leu Lys Met Lys Val Gly Asn His 
            660                 665             


<210>  11
<211>  660
<212>  PRT
<213>  Hepatitis E virus

<400>  11

Met Arg Pro Arg Pro Ile Leu Leu Leu Leu Leu Met Phe Leu Pro Met 
1               5                   10                  15      


Leu Pro Ala Pro Pro Pro Gly Gln Pro Ser Gly Arg Arg Arg Gly Arg 
            20                  25                  30          


Arg Ser Gly Gly Ser Gly Gly Gly Phe Trp Gly Asp Arg Ala Asp Ser 
        35                  40                  45              


Gln Pro Phe Ala Ile Pro Tyr Ile His Pro Thr Asn Pro Phe Ala Pro 
    50                  55                  60                  


Asp Val Thr Ala Ala Ala Gly Ala Gly Pro Arg Val Arg Gln Pro Ala 
65                  70                  75                  80  


Arg Pro Leu Gly Ser Ala Trp Arg Asp Gln Ala Gln Arg Pro Ala Ala 
                85                  90                  95      


Ala Ser Arg Arg Arg Pro Thr Thr Ala Gly Ala Ala Pro Leu Thr Ala 
            100                 105                 110         


Val Ala Pro Ala His Asp Thr Pro Pro Val Pro Asp Val Asp Ser Arg 
        115                 120                 125             


Gly Ala Ile Leu Arg Arg Gln Tyr Asn Leu Ser Thr Ser Pro Leu Thr 
    130                 135                 140                 


Ser Ser Val Ala Thr Gly Thr Asn Leu Val Leu Tyr Ala Ala Pro Leu 
145                 150                 155                 160 


Ser Pro Leu Leu Pro Leu Gln Asp Gly Thr Asn Thr His Ile Met Ala 
                165                 170                 175     


Thr Glu Ala Ser Asn Tyr Ala Gln Tyr Arg Val Val Arg Ala Thr Ile 
            180                 185                 190         


Arg Tyr Arg Pro Leu Val Pro Asn Ala Val Gly Gly Tyr Ala Ile Ser 
        195                 200                 205             


Ile Ser Phe Trp Pro Gln Thr Thr Thr Thr Pro Thr Ser Val Asp Met 
    210                 215                 220                 


Asn Ser Ile Thr Ser Thr Asp Val Arg Ile Leu Val Gln Pro Gly Ile 
225                 230                 235                 240 


Ala Ser Glu His Val Ile Pro Ser Glu Arg Leu His Tyr Arg Asn Gln 
                245                 250                 255     


Gly Trp Arg Ser Val Glu Thr Ser Gly Val Ala Glu Glu Glu Ala Thr 
            260                 265                 270         


Ser Gly Leu Val Met Leu Cys Ile His Gly Ser Leu Val Asn Ser Tyr 
        275                 280                 285             


Thr Asn Thr Pro Tyr Thr Gly Ala Leu Gly Leu Leu Asp Phe Ala Leu 
    290                 295                 300                 


Glu Leu Glu Phe Arg Asn Leu Thr Pro Gly Asn Thr Asn Thr Arg Val 
305                 310                 315                 320 


Ser Arg Tyr Ser Ser Thr Ala Arg His Arg Leu Arg Arg Gly Ala Asp 
                325                 330                 335     


Gly Thr Ala Glu Leu Thr Thr Thr Ala Ala Thr Arg Phe Met Lys Asp 
            340                 345                 350         


Leu Tyr Phe Thr Ser Thr Asn Gly Val Gly Glu Ile Gly Arg Gly Ile 
        355                 360                 365             


Ala Leu Thr Leu Phe Asn Leu Ala Asp Thr Leu Leu Gly Gly Leu Pro 
    370                 375                 380                 


Thr Glu Leu Ile Ser Ser Ala Gly Gly Gln Leu Phe Tyr Ser Arg Pro 
385                 390                 395                 400 


Val Val Ser Ala Asn Gly Glu Pro Thr Val Lys Leu Tyr Thr Ser Val 
                405                 410                 415     


Glu Asn Ala Gln Gln Asp Lys Gly Ile Ala Ile Pro His Asp Ile Asp 
            420                 425                 430         


Leu Gly Glu Ser Arg Val Val Ile Gln Asp Tyr Asp Asn Gln His Glu 
        435                 440                 445             


Gln Asp Arg Pro Thr Pro Ser Pro Ala Pro Ser Arg Pro Phe Ser Val 
    450                 455                 460                 


Leu Arg Ala Asn Asp Val Leu Trp Leu Ser Leu Thr Ala Ala Glu Tyr 
465                 470                 475                 480 


Asp Gln Ser Thr Tyr Gly Ser Ser Thr Gly Pro Val Tyr Val Ser Asp 
                485                 490                 495     


Ser Val Thr Leu Val Asn Val Ala Thr Gly Ala Gln Ala Val Ala Arg 
            500                 505                 510         


Ser Leu Asp Trp Thr Lys Val Thr Leu Asp Gly Arg Pro Leu Ser Thr 
        515                 520                 525             


Thr Gln Gln Tyr Ser Lys Thr Phe Phe Val Leu Pro Leu Arg Gly Lys 
    530                 535                 540                 


Leu Ser Phe Trp Glu Ala Gly Thr Thr Lys Ala Gly Tyr Pro Tyr Asn 
545                 550                 555                 560 


Tyr Asn Thr Thr Ala Ser Asp Gln Leu Leu Val Glu Asn Ala Ala Gly 
                565                 570                 575     


His Arg Val Ala Ile Ser Thr Tyr Thr Thr Ser Leu Gly Ala Gly Pro 
            580                 585                 590         


Val Ser Ile Ser Ala Val Ala Val Leu Ala Pro His Ser Ala Leu Ala 
        595                 600                 605             


Leu Leu Glu Asp Thr Met Asp Tyr Pro Ala Arg Ala His Thr Phe Asp 
    610                 615                 620                 


Asp Phe Cys Pro Glu Cys Arg Pro Leu Gly Leu Gln Gly Cys Ala Phe 
625                 630                 635                 640 


Gln Ser Thr Val Ala Glu Leu Gln Arg Leu Lys Met Lys Val Gly Lys 
                645                 650                 655     


Thr Arg Glu Leu 
            660 


<210>  12
<211>  660
<212>  PRT
<213>  Hepatitis E virus

<400>  12

Met Arg Pro Arg Pro Ile Leu Leu Leu Leu Leu Met Phe Leu Pro Met 
1               5                   10                  15      


Leu Pro Ala Pro Pro Pro Gly Gln Pro Ser Gly Arg Arg Arg Gly Arg 
            20                  25                  30          


Arg Ser Gly Gly Ser Gly Gly Gly Phe Trp Gly Asp Arg Val Asp Ser 
        35                  40                  45              


Gln Pro Phe Ala Ile Pro Tyr Ile His Pro Thr Asn Pro Phe Ala Pro 
    50                  55                  60                  


Asp Val Thr Ala Ala Ala Gly Ala Gly Pro Arg Val Arg Gln Pro Ala 
65                  70                  75                  80  


Arg Pro Leu Gly Ser Ala Trp Arg Asp Gln Ala Gln Arg Pro Ala Val 
                85                  90                  95      


Ala Ser Arg Arg Arg Pro Thr Thr Ala Gly Ala Ala Pro Leu Thr Ala 
            100                 105                 110         


Val Ala Pro Ala His Asp Thr Pro Pro Val Pro Asp Val Asp Ser Arg 
        115                 120                 125             


Gly Ala Ile Leu Arg Arg Gln Tyr Asn Leu Ser Thr Ser Pro Leu Thr 
    130                 135                 140                 


Ser Ser Val Ala Thr Gly Thr Asn Leu Val Leu Tyr Ala Ala Pro Leu 
145                 150                 155                 160 


Ser Pro Leu Leu Pro Leu Gln Asp Gly Thr Asn Thr His Ile Met Ala 
                165                 170                 175     


Thr Glu Ala Ser Asn Tyr Ala Gln Tyr Arg Val Ala Arg Ala Thr Ile 
            180                 185                 190         


Arg Tyr Arg Pro Leu Val Pro Asn Ala Val Gly Gly Tyr Ala Ile Ser 
        195                 200                 205             


Ile Ser Phe Trp Pro Gln Thr Thr Thr Thr Pro Thr Ser Val Asp Met 
    210                 215                 220                 


Asn Ser Ile Thr Ser Thr Asp Val Arg Ile Leu Val Gln Pro Gly Ile 
225                 230                 235                 240 


Ala Ser Glu Leu Val Ile Pro Ser Glu Arg Leu His Tyr Arg Asn Gln 
                245                 250                 255     


Gly Trp Arg Ser Val Glu Thr Ser Gly Val Ala Glu Glu Glu Ala Thr 
            260                 265                 270         


Ser Gly Leu Val Met Leu Cys Ile His Gly Ser Leu Val Asn Ser Tyr 
        275                 280                 285             


Thr Asn Thr Pro Tyr Thr Gly Ala Leu Gly Leu Leu Asp Phe Ala Leu 
    290                 295                 300                 


Glu Leu Glu Phe Arg Asn Leu Thr Pro Gly Asn Thr Asn Thr Arg Val 
305                 310                 315                 320 


Ser Arg Tyr Ser Ser Thr Ala Arg His Arg Leu Arg Arg Gly Ala Asp 
                325                 330                 335     


Gly Thr Ala Glu Leu Thr Thr Thr Ala Ala Thr Arg Phe Met Lys Asp 
            340                 345                 350         


Leu Tyr Phe Thr Ser Thr Asn Gly Val Gly Glu Ile Gly Arg Gly Ile 
        355                 360                 365             


Ala Leu Thr Leu Phe Asn Leu Ala Asp Thr Leu Leu Gly Gly Leu Pro 
    370                 375                 380                 


Thr Glu Leu Ile Ser Ser Ala Gly Gly Gln Leu Phe Tyr Ser Arg Pro 
385                 390                 395                 400 


Val Val Ser Ala Asn Gly Glu Pro Thr Val Lys Leu Tyr Thr Ser Val 
                405                 410                 415     


Glu Asn Ala Gln Gln Asp Lys Gly Ile Ala Ile Pro His Asp Ile Asp 
            420                 425                 430         


Leu Gly Glu Ser Arg Val Val Ile Gln Asp Tyr Asp Asn Gln His Glu 
        435                 440                 445             


Gln Asp Arg Pro Thr Pro Ser Pro Ala Pro Ser Arg Pro Phe Ser Val 
    450                 455                 460                 


Leu Arg Ala Asn Asp Val Leu Trp Leu Ser Leu Thr Ala Ala Glu Tyr 
465                 470                 475                 480 


Asp Gln Ser Thr Tyr Gly Ser Ser Thr Gly Pro Val Tyr Val Ser Asp 
                485                 490                 495     


Ser Val Thr Leu Val Asn Val Ala Thr Gly Ala Gln Ala Val Ala Arg 
            500                 505                 510         


Ser Leu Asp Trp Thr Lys Val Thr Leu Asp Gly Arg Pro Leu Ser Thr 
        515                 520                 525             


Ile Gln Gln Tyr Ser Lys Thr Phe Phe Val Leu Pro Leu Arg Gly Lys 
    530                 535                 540                 


Leu Ser Phe Trp Glu Ala Gly Thr Thr Lys Ala Gly Tyr Pro Tyr Asn 
545                 550                 555                 560 


Tyr Asn Thr Thr Ala Ser Asp Gln Leu Leu Val Glu Asn Ala Ala Gly 
                565                 570                 575     


His Arg Val Ala Ile Ser Thr Tyr Thr Thr Ser Leu Gly Ala Gly Pro 
            580                 585                 590         


Val Ser Ile Ser Ala Val Ala Val Leu Ala Pro His Ser Ala Leu Ala 
        595                 600                 605             


Leu Leu Glu Asp Thr Leu Asp Tyr Pro Ala Arg Ala His Thr Phe Asp 
    610                 615                 620                 


Asp Phe Cys Pro Glu Cys Arg Pro Leu Gly Leu Gln Gly Cys Ala Phe 
625                 630                 635                 640 


Gln Ser Thr Val Ala Glu Leu Gln Arg Leu Lys Met Lys Val Gly Lys 
                645                 650                 655     


Thr Arg Glu Leu 
            660 


<210>  13
<211>  660
<212>  PRT
<213>  Hepatitis E virus

<400>  13

Met Arg Pro Arg Ala Val Leu Leu Leu Leu Phe Val Leu Leu Pro Met 
1               5                   10                  15      


Leu Pro Ala Pro Pro Ala Gly Gln Pro Ser Gly Arg Arg Arg Gly Arg 
            20                  25                  30          


Arg Asn Gly Gly Ala Gly Gly Gly Phe Trp Gly Asp Arg Val Asp Ser 
        35                  40                  45              


Gln Pro Phe Ala Leu Pro Tyr Ile His Pro Thr Asn Pro Phe Ala Ala 
    50                  55                  60                  


Asp Val Val Ser Gln Pro Gly Ala Gly Ala Arg Pro Arg Gln Pro Pro 
65                  70                  75                  80  


Arg Pro Leu Gly Ser Ala Trp Arg Asp Gln Ser Gln Arg Pro Ser Thr 
                85                  90                  95      


Ala Pro Arg Arg Arg Ser Ala Pro Ala Gly Ala Ala Pro Leu Thr Ala 
            100                 105                 110         


Val Ser Pro Ala Pro Asp Thr Ala Pro Val Pro Asp Val Asp Ser Arg 
        115                 120                 125             


Gly Ala Ile Leu Arg Arg Gln Tyr Asn Leu Ser Thr Ser Pro Leu Thr 
    130                 135                 140                 


Ser Ser Val Ala Ala Gly Thr Asn Leu Val Leu Tyr Ala Ala Pro Leu 
145                 150                 155                 160 


Asn Pro Leu Leu Pro Leu Gln Asp Gly Thr Asn Thr His Ile Met Ala 
                165                 170                 175     


Thr Glu Ala Ser Asn Tyr Ala Gln Tyr Arg Val Val Arg Ala Thr Ile 
            180                 185                 190         


Arg Tyr Arg Pro Leu Val Pro Asn Ala Val Gly Gly Tyr Ala Ile Ser 
        195                 200                 205             


Ile Ser Phe Trp Pro Gln Thr Thr Thr Thr Pro Thr Ser Val Asp Met 
    210                 215                 220                 


Asn Ser Ile Thr Ser Thr Asp Val Arg Ile Leu Val Gln Pro Gly Ile 
225                 230                 235                 240 


Ala Ser Glu Leu Val Ile Pro Ser Glu Arg Leu His Tyr Arg Asn Gln 
                245                 250                 255     


Gly Trp Arg Ser Val Glu Thr Thr Gly Val Ala Glu Glu Glu Ala Thr 
            260                 265                 270         


Ser Gly Leu Val Met Leu Cys Ile His Gly Ser Pro Val Asn Ser Tyr 
        275                 280                 285             


Thr Asn Thr Pro Tyr Thr Gly Ala Leu Gly Leu Leu Asp Phe Ala Leu 
    290                 295                 300                 


Glu Leu Glu Phe Arg Asn Leu Thr Pro Gly Asn Thr Asn Thr Arg Val 
305                 310                 315                 320 


Ser Arg Tyr Thr Ser Thr Ala Arg His Arg Leu Arg Arg Gly Ala Asp 
                325                 330                 335     


Gly Thr Ala Glu Leu Thr Thr Thr Ala Ala Thr Arg Phe Met Lys Asp 
            340                 345                 350         


Leu His Phe Thr Gly Thr Asn Gly Val Gly Glu Val Gly Arg Gly Ile 
        355                 360                 365             


Ala Leu Thr Leu Phe Asn Leu Ala Asp Thr Leu Leu Gly Gly Leu Pro 
    370                 375                 380                 


Thr Glu Leu Ile Ser Ser Ala Gly Gly Gln Leu Phe Tyr Ser Arg Pro 
385                 390                 395                 400 


Val Val Ser Ala Asn Gly Glu Pro Thr Val Lys Leu Tyr Thr Ser Val 
                405                 410                 415     


Glu Asn Ala Gln Gln Asp Lys Gly Ile Thr Ile Pro His Asp Ile Asp 
            420                 425                 430         


Leu Gly Asp Ser Arg Val Val Ile Gln Asp Tyr Asp Asn Gln His Glu 
        435                 440                 445             


Gln Asp Arg Pro Thr Pro Ser Pro Ala Pro Ser Arg Pro Phe Ser Val 
    450                 455                 460                 


Leu Arg Ala Asn Asp Val Leu Trp Leu Ser Leu Thr Ala Ala Glu Tyr 
465                 470                 475                 480 


Asp Gln Thr Thr Tyr Gly Ser Ser Thr Asn Pro Met Tyr Val Ser Asp 
                485                 490                 495     


Thr Val Thr Leu Val Asn Val Ala Thr Gly Ala Gln Ala Val Ala Arg 
            500                 505                 510         


Ser Leu Asp Trp Ser Lys Val Thr Leu Asp Gly Arg Pro Leu Thr Thr 
        515                 520                 525             


Ile Gln Gln Tyr Ser Lys Thr Phe Tyr Val Leu Pro Leu Arg Gly Lys 
    530                 535                 540                 


Leu Ser Phe Trp Glu Ala Gly Thr Thr Lys Ala Gly Tyr Pro Tyr Asn 
545                 550                 555                 560 


Tyr Asn Thr Thr Ala Ser Asp Gln Ile Leu Ile Glu Asn Ala Ala Gly 
                565                 570                 575     


His Arg Val Ala Ile Ser Thr Tyr Thr Thr Ser Leu Gly Ala Gly Pro 
            580                 585                 590         


Thr Ser Ile Ser Ala Val Gly Val Leu Ala Pro His Ser Ala Leu Ala 
        595                 600                 605             


Val Leu Glu Asp Thr Val Asp Tyr Pro Ala Arg Ala His Thr Phe Asp 
    610                 615                 620                 


Asp Phe Cys Pro Glu Cys Arg Thr Leu Gly Leu Gln Gly Cys Ala Phe 
625                 630                 635                 640 


Gln Ser Thr Ile Ala Glu Leu Gln Arg Leu Lys Met Lys Val Gly Lys 
                645                 650                 655     


Thr Arg Glu Ser 
            660 


<210>  14
<211>  660
<212>  PRT
<213>  Hepatitis E virus

<400>  14

Met Arg Pro Arg Pro Ile Leu Leu Leu Leu Leu Met Phe Leu Pro Met 
1               5                   10                  15      


Leu Pro Ala Pro Pro Pro Gly Gln Pro Ser Gly Arg Arg Arg Gly Arg 
            20                  25                  30          


Arg Ser Gly Gly Ser Gly Gly Gly Phe Trp Gly Asp Arg Val Asp Ser 
        35                  40                  45              


Gln Pro Phe Ala Ile Pro Tyr Ile His Pro Thr Asn Pro Phe Ala Pro 
    50                  55                  60                  


Asp Val Thr Ala Ala Ala Gly Ala Gly Pro Arg Val Arg Gln Pro Ala 
65                  70                  75                  80  


Arg Pro Leu Gly Ser Ala Trp Arg Asp Gln Ala Gln Arg Pro Ala Val 
                85                  90                  95      


Ala Ser Arg Arg Arg Pro Thr Thr Ala Gly Ala Ala Pro Leu Thr Ala 
            100                 105                 110         


Val Ala Pro Ala His Asp Thr Pro Pro Val Pro Asp Val Asp Ser Arg 
        115                 120                 125             


Ala Ala Ile Leu Arg Arg Gln Tyr Asn Leu Ser Thr Ser Pro Leu Thr 
    130                 135                 140                 


Ser Ser Val Ala Thr Gly Thr Asn Leu Val Leu Tyr Ala Ala Pro Leu 
145                 150                 155                 160 


Ser Pro Leu Leu Pro Leu Gln Asp Gly Thr Asn Thr His Ile Met Ala 
                165                 170                 175     


Thr Glu Ala Ser Asn Tyr Ala Gln Tyr Arg Val Val Arg Ala Thr Ile 
            180                 185                 190         


Arg Tyr Arg Pro Leu Val Pro Asn Ala Val Gly Gly Tyr Ala Ile Ser 
        195                 200                 205             


Ile Ser Phe Trp Pro Gln Thr Thr Thr Thr Pro Thr Ser Val Asp Met 
    210                 215                 220                 


Asn Ser Ile Thr Ser Thr Asp Val Arg Ile Leu Val Gln Pro Gly Ile 
225                 230                 235                 240 


Ala Ser Glu Leu Val Ile Pro Ser Glu Arg Leu His Tyr Arg Asn Gln 
                245                 250                 255     


Gly Trp Arg Ser Val Glu Thr Ser Gly Val Ala Glu Glu Glu Ala Thr 
            260                 265                 270         


Ser Gly Leu Val Met Leu Cys Ile His Gly Ser Pro Val Asn Ser Tyr 
        275                 280                 285             


Thr Asn Thr Pro Tyr Thr Gly Ala Leu Gly Leu Leu Asp Phe Ala Leu 
    290                 295                 300                 


Glu Leu Glu Phe Arg Asn Leu Thr Pro Gly Asn Thr Asn Thr Arg Val 
305                 310                 315                 320 


Ser Arg Tyr Ser Ser Thr Ala Arg His Arg Leu Arg Arg Gly Ala Asp 
                325                 330                 335     


Gly Thr Ala Glu Leu Thr Thr Thr Ala Ala Thr Arg Phe Met Lys Asp 
            340                 345                 350         


Leu Tyr Phe Thr Ser Thr Asn Gly Val Gly Glu Ile Gly Arg Gly Ile 
        355                 360                 365             


Ala Leu Thr Leu Phe Asn Leu Ala Asp Thr Leu Leu Gly Gly Leu Pro 
    370                 375                 380                 


Thr Glu Leu Ile Ser Ser Ala Gly Gly Gln Leu Phe Tyr Ser Arg Pro 
385                 390                 395                 400 


Val Val Ser Ala His Gly Glu Pro Thr Val Lys Leu Tyr Thr Ser Val 
                405                 410                 415     


Glu Asn Ala Gln Gln Asp Lys Gly Ile Ala Ile Pro His Asp Ile Asp 
            420                 425                 430         


Leu Gly Glu Ser Arg Val Val Ile Gln Asp Tyr Asp Asn Gln His Glu 
        435                 440                 445             


Gln Asp Arg Pro Thr Pro Ser Pro Ala Pro Ser Arg Pro Phe Ser Val 
    450                 455                 460                 


Leu Arg Ala Asn Asp Val Leu Trp Leu Ser Leu Thr Ala Ala Glu Tyr 
465                 470                 475                 480 


Asp Gln Ser Thr Tyr Gly Ser Ser Thr Ala Pro Val Tyr Val Ser Asp 
                485                 490                 495     


Ser Val Thr Leu Val Asn Val Ala Thr Gly Ala Gln Ala Val Ala Arg 
            500                 505                 510         


Ser Leu Asp Trp Thr Lys Val Thr Leu Asp Gly Arg Pro Leu Ser Thr 
        515                 520                 525             


Ile Gln Gln Tyr Pro Lys Thr Phe Phe Val Leu Pro Leu Arg Gly Lys 
    530                 535                 540                 


Leu Ser Phe Trp Glu Ala Gly Thr Thr Lys Ala Gly Tyr Pro Tyr Asn 
545                 550                 555                 560 


Tyr Asn Thr Thr Ala Ser Asp Gln Leu Leu Val Glu Asn Ala Ala Gly 
                565                 570                 575     


His Arg Val Ala Ile Ser Thr Tyr Thr Thr Ser Leu Gly Ala Gly Pro 
            580                 585                 590         


Val Ser Ile Ser Ala Val Ala Val Leu Ala Pro His Ser Ala Leu Ala 
        595                 600                 605             


Leu Leu Glu Asp Thr Leu Asp Tyr Pro Ala Cys Ala His Thr Phe Asp 
    610                 615                 620                 


Asp Phe Cys Pro Glu Cys Arg Pro Leu Gly Leu Gln Gly Cys Ala Phe 
625                 630                 635                 640 


Gln Ser Thr Val Ala Glu Leu Gln Arg Leu Lys Met Lys Val Gly Lys 
                645                 650                 655     


Thr Arg Glu Leu 
            660 


<210>  15
<211>  660
<212>  PRT
<213>  Hepatitis E virus

<400>  15

Met Gly Pro Arg Pro Ile Leu Leu Leu Phe Leu Met Phe Leu Pro Met 
1               5                   10                  15      


Leu Leu Ala Pro Pro Pro Gly Gln Pro Ser Gly Arg Arg Arg Gly Arg 
            20                  25                  30          


Arg Ser Gly Gly Ser Gly Gly Gly Phe Trp Gly Asp Arg Val Asp Ser 
        35                  40                  45              


Gln Pro Phe Ala Ile Pro Tyr Ile His Pro Thr Asn Pro Phe Ala Pro 
    50                  55                  60                  


Asn Val Thr Ala Ala Ala Gly Ala Gly Pro Arg Val Arg Gln Pro Val 
65                  70                  75                  80  


Arg Pro Leu Gly Ser Ala Trp Arg Asp Gln Ala Gln Arg Pro Ala Ala 
                85                  90                  95      


Ala Ser Arg Arg Arg Pro Thr Thr Ala Gly Ala Ala Pro Leu Thr Ala 
            100                 105                 110         


Val Ala Pro Ala His Asp Thr Pro Pro Val Pro Asp Val Asp Ser Arg 
        115                 120                 125             


Gly Ala Ile Leu Arg Arg Gln Tyr Asn Leu Ser Thr Ser Pro Leu Thr 
    130                 135                 140                 


Ser Ser Val Ala Thr Gly Thr Asn Leu Val Leu Tyr Ala Ala Pro Leu 
145                 150                 155                 160 


Ser Pro Leu Leu Pro Leu Gln Asp Gly Thr Asn Thr His Ile Met Ala 
                165                 170                 175     


Thr Glu Ala Ser Asn Tyr Ala Gln Tyr Arg Val Ala Arg Ala Thr Ile 
            180                 185                 190         


Arg Tyr Arg Pro Leu Val Pro Asn Ala Val Gly Gly Tyr Ala Ile Ser 
        195                 200                 205             


Ile Ser Phe Trp Pro Gln Thr Thr Pro Thr Pro Thr Ser Val Asp Met 
    210                 215                 220                 


Asn Ser Ile Thr Ser Thr Asp Val Arg Ile Leu Val Gln Pro Gly Ile 
225                 230                 235                 240 


Ala Ser Glu Leu Val Ile Pro Ser Glu Arg Leu His Tyr Arg Asn Gln 
                245                 250                 255     


Gly Trp Arg Ser Val Glu Thr Ser Gly Val Ala Glu Glu Glu Ala Thr 
            260                 265                 270         


Ser Gly Leu Val Met Leu Cys Ile His Gly Ser Pro Val Asn Ser Tyr 
        275                 280                 285             


Thr Asn Thr Pro Tyr Thr Gly Ala Leu Gly Leu Leu Asp Phe Ala Leu 
    290                 295                 300                 


Glu Leu Glu Phe Arg Asn Leu Thr Pro Gly Asn Thr Asn Thr Arg Val 
305                 310                 315                 320 


Ser Arg Tyr Ser Ser Thr Ala Arg His Arg Leu Arg Arg Gly Ala Asp 
                325                 330                 335     


Gly Thr Ala Glu Leu Thr Thr Thr Ala Ala Thr Arg Phe Met Lys Asp 
            340                 345                 350         


Leu Tyr Phe Thr Ser Thr Asn Gly Val Gly Glu Ile Gly Arg Gly Ile 
        355                 360                 365             


Ala Leu Thr Leu Phe Asn Leu Ala Asp Thr Leu Leu Gly Gly Leu Pro 
    370                 375                 380                 


Thr Glu Leu Ile Ser Ser Ala Gly Gly Gln Leu Phe Tyr Ser Arg Pro 
385                 390                 395                 400 


Val Val Ser Ala Asn Gly Glu Pro Thr Val Lys Leu Tyr Thr Ser Val 
                405                 410                 415     


Glu Asn Ala Gln Gln Asp Lys Gly Ile Ala Ile Pro Asn Asp Ile Asp 
            420                 425                 430         


Leu Gly Glu Ser Arg Val Val Ile Gln Asp Tyr Asp Asn Gln His Glu 
        435                 440                 445             


Gln Asp Arg Pro Thr Pro Ser Pro Ala Pro Ser Arg Pro Phe Ser Val 
    450                 455                 460                 


Leu Arg Ala Asn Asp Val Leu Trp Leu Ser Leu Thr Ala Ala Glu Tyr 
465                 470                 475                 480 


Asp Gln Ser Thr Tyr Gly Ser Ser Thr Gly Pro Val Tyr Val Ser Asp 
                485                 490                 495     


Ser Val Thr Leu Val Asn Val Ala Thr Gly Ala Gln Ala Val Ala Arg 
            500                 505                 510         


Ser Leu Asp Trp Thr Lys Val Thr Leu Asp Gly Arg Pro Leu Ser Thr 
        515                 520                 525             


Ile Gln Gln Tyr Ser Lys Ile Phe Phe Val Leu Pro Leu Arg Gly Lys 
    530                 535                 540                 


Leu Ser Phe Trp Glu Ala Gly Thr Thr Arg Pro Gly Tyr Pro Tyr Asn 
545                 550                 555                 560 


Tyr Asn Thr Thr Ala Ser Asp Gln Leu Leu Val Glu Asn Ala Ala Gly 
                565                 570                 575     


His Arg Val Ala Ile Ser Thr Tyr Thr Thr Ser Leu Gly Ala Gly Pro 
            580                 585                 590         


Val Ser Ile Ser Ala Val Ala Val Leu Gly Pro His Ser Ala Leu Ala 
        595                 600                 605             


Leu Leu Glu Asp Thr Leu Asp Tyr Pro Ala Arg Ala His Thr Phe Asp 
    610                 615                 620                 


Asp Phe Cys Pro Glu Cys Arg Pro Leu Gly Leu Gln Gly Cys Ala Phe 
625                 630                 635                 640 


Gln Ser Thr Val Ala Glu Leu Gln Arg Leu Lys Met Lys Val Gly Lys 
                645                 650                 655     


Thr Arg Glu Leu 
            660 


<210>  16
<211>  660
<212>  PRT
<213>  Hepatitis E virus

<400>  16

Met Arg Pro Arg Ala Val Leu Leu Leu Leu Phe Val Leu Leu Pro Met 
1               5                   10                  15      


Leu Pro Ala Pro Pro Ala Gly Gln Pro Ser Gly Arg Arg Arg Gly Arg 
            20                  25                  30          


Arg Ser Gly Gly Ala Gly Gly Gly Phe Trp Gly Asp Arg Val Asp Ser 
        35                  40                  45              


Gln Pro Phe Ala Leu Pro Tyr Ile His Pro Thr Asn Pro Phe Ala Ala 
    50                  55                  60                  


Asp Val Val Ser Gln Pro Gly Ala Gly Thr Arg Pro Arg Gln Pro Pro 
65                  70                  75                  80  


Arg Pro Leu Gly Ser Ala Trp Arg Asp Gln Ser Gln Arg Pro Ser Ala 
                85                  90                  95      


Ala Pro Arg Arg Arg Ser Ala Pro Ala Gly Ala Ala Pro Leu Thr Ala 
            100                 105                 110         


Val Ser Pro Ala Pro Asp Thr Ala Pro Val Pro Asp Val Asp Ser Arg 
        115                 120                 125             


Gly Ala Ile Leu Arg Arg Gln Tyr Asn Leu Ser Thr Ser Pro Leu Thr 
    130                 135                 140                 


Ser Ser Val Ala Ser Gly Thr Asn Leu Val Leu Tyr Ala Ala Pro Leu 
145                 150                 155                 160 


Asn Pro Leu Leu Pro Leu Gln Asp Gly Thr Asn Thr His Ile Met Ala 
                165                 170                 175     


Thr Glu Ala Ser Asn Tyr Ala Gln Tyr Arg Val Val Arg Ala Thr Ile 
            180                 185                 190         


Arg Tyr Arg Pro Leu Val Pro Asn Ala Val Gly Gly Tyr Ala Ile Ser 
        195                 200                 205             


Ile Ser Phe Trp Pro Gln Thr Thr Thr Thr Pro Thr Ser Val Asp Met 
    210                 215                 220                 


Asn Ser Ile Thr Ser Thr Asp Val Arg Ile Leu Val Gln Pro Gly Ile 
225                 230                 235                 240 


Ala Ser Glu Leu Val Ile Pro Ser Glu Arg Leu His Tyr Arg Asn Gln 
                245                 250                 255     


Gly Trp Arg Ser Val Glu Thr Thr Gly Val Ala Glu Glu Glu Ala Thr 
            260                 265                 270         


Ser Gly Leu Val Met Leu Cys Ile His Gly Ser Pro Val Asn Ser Tyr 
        275                 280                 285             


Thr Asn Thr Pro Tyr Thr Gly Ala Leu Gly Leu Leu Asp Phe Ala Leu 
    290                 295                 300                 


Glu Leu Glu Phe Arg Asn Leu Thr Pro Gly Asn Thr Asn Thr Arg Val 
305                 310                 315                 320 


Ser Arg Tyr Thr Ser Thr Ala Arg His Arg Leu Arg Arg Gly Ala Asp 
                325                 330                 335     


Gly Thr Ala Glu Leu Thr Thr Thr Ala Ala Thr Arg Phe Met Lys Asp 
            340                 345                 350         


Leu His Phe Ala Gly Thr Asn Gly Val Gly Glu Val Gly Arg Gly Ile 
        355                 360                 365             


Ala Leu Thr Leu Phe Asn Leu Ala Asp Thr Leu Leu Gly Gly Leu Pro 
    370                 375                 380                 


Thr Glu Leu Ile Ser Ser Ala Gly Gly Gln Leu Phe Tyr Ser Arg Pro 
385                 390                 395                 400 


Val Val Ser Ala Asn Gly Glu Pro Thr Val Lys Leu Tyr Thr Ser Val 
                405                 410                 415     


Glu Asn Ala Gln Gln Asp Lys Gly Ile Thr Ile Pro His Asp Ile Asp 
            420                 425                 430         


Leu Gly Asp Ser Arg Val Val Ile Gln Asp Tyr Asp Asn Gln His Glu 
        435                 440                 445             


Gln Asp Arg Pro Thr Pro Ser Pro Ala Pro Ser Arg Pro Phe Ser Val 
    450                 455                 460                 


Leu Arg Ala Asn Asp Val Leu Trp Leu Ser Leu Thr Ala Ala Glu Tyr 
465                 470                 475                 480 


Asp Gln Thr Thr Tyr Gly Ser Ser Thr Asn Pro Met Tyr Val Ser Asp 
                485                 490                 495     


Thr Val Thr Leu Val Asn Val Ala Thr Gly Ala Gln Ala Val Ala Arg 
            500                 505                 510         


Ser Leu Asp Trp Ser Lys Val Thr Leu Asp Gly Arg Pro Leu Thr Thr 
        515                 520                 525             


Ile Gln Gln Tyr Ser Lys Thr Phe Tyr Val Leu Pro Leu Arg Gly Lys 
    530                 535                 540                 


Leu Ser Phe Trp Glu Ala Gly Thr Thr Lys Ala Gly Tyr Pro Tyr Asn 
545                 550                 555                 560 


Tyr Asn Thr Thr Ala Ser Asp Gln Ile Leu Ile Glu Asn Ala Ala Gly 
                565                 570                 575     


His Arg Val Ala Ile Ser Thr Tyr Thr Thr Ser Leu Gly Ala Gly Pro 
            580                 585                 590         


Thr Ser Ile Ser Ala Val Gly Val Leu Ala Pro His Ser Ala Leu Ala 
        595                 600                 605             


Val Leu Glu Asp Thr Ile Asp Tyr Pro Ala Arg Ala His Thr Phe Asp 
    610                 615                 620                 


Asp Phe Cys Pro Glu Cys Arg Thr Leu Gly Leu Gln Gly Cys Ala Phe 
625                 630                 635                 640 


Gln Ser Thr Ile Ala Glu Leu Gln Arg Leu Lys Met Lys Val Gly Lys 
                645                 650                 655     


Thr Arg Glu Ser 
            660 


<210>  17
<211>  660
<212>  PRT
<213>  Hepatitis E virus

<400>  17

Met Arg Pro Arg Pro Ile Leu Leu Leu Leu Leu Met Phe Leu Pro Met 
1               5                   10                  15      


Leu Pro Ala Pro Pro Pro Gly Gln Pro Ser Gly Arg Arg Arg Gly Arg 
            20                  25                  30          


Arg Ser Gly Gly Ser Gly Gly Gly Phe Trp Gly Asp Arg Val Asp Ser 
        35                  40                  45              


Gln Pro Phe Ala Ile Pro Tyr Ile His Pro Thr Asn Pro Phe Ala Pro 
    50                  55                  60                  


Asp Val Thr Ala Ala Ala Gly Ala Gly Pro Arg Val Arg Gln Pro Ala 
65                  70                  75                  80  


Arg Pro Leu Gly Ser Ala Trp Arg Asp Gln Ala Gln Arg Pro Ala Ala 
                85                  90                  95      


Ala Ser Arg Arg Arg Pro Thr Thr Ala Gly Ala Ala Pro Leu Thr Ala 
            100                 105                 110         


Val Ala Pro Ala His Asp Thr Pro Pro Val Pro Asp Val Asp Ser Arg 
        115                 120                 125             


Gly Ala Ile Leu Arg Arg Gln Tyr Asn Leu Ser Thr Ser Pro Leu Thr 
    130                 135                 140                 


Ser Ser Val Ala Thr Gly Thr Asn Leu Val Leu Tyr Ala Ala Pro Leu 
145                 150                 155                 160 


Ser Pro Leu Leu Pro Leu Gln Asp Gly Thr Asn Thr His Ile Met Ala 
                165                 170                 175     


Thr Glu Ala Ser Asn Tyr Ala Gln Tyr Arg Val Ala Arg Ala Thr Ile 
            180                 185                 190         


Arg Tyr Arg Pro Leu Val Pro Asn Ala Val Gly Gly Tyr Ala Ile Ser 
        195                 200                 205             


Ile Ser Phe Trp Pro Gln Thr Thr Thr Thr Pro Thr Ser Val Asp Met 
    210                 215                 220                 


Asn Ser Ile Thr Ser Thr Asp Val Arg Ile Leu Val Gln Pro Gly Ile 
225                 230                 235                 240 


Ala Ser Glu Leu Val Ile Pro Ser Glu Arg Leu His Tyr Arg Asn Gln 
                245                 250                 255     


Gly Trp Arg Ser Val Glu Thr Ser Gly Val Ala Glu Glu Glu Ala Thr 
            260                 265                 270         


Ser Gly Leu Val Met Leu Cys Ile His Gly Ser Pro Val Asn Ser Tyr 
        275                 280                 285             


Thr Asn Thr Pro Tyr Thr Gly Ala Leu Gly Leu Leu Asp Phe Ala Leu 
    290                 295                 300                 


Glu Leu Glu Phe Arg Asn Leu Thr Pro Gly Asn Thr Asn Thr Arg Val 
305                 310                 315                 320 


Ser Arg Tyr Ser Ser Thr Ala Arg His Arg Leu Arg Arg Gly Ala Asp 
                325                 330                 335     


Gly Thr Ala Glu Leu Thr Thr Thr Ala Ala Thr Arg Phe Met Lys Asp 
            340                 345                 350         


Leu Tyr Phe Thr Ser Thr Asn Gly Val Gly Glu Ile Gly Arg Gly Ile 
        355                 360                 365             


Ala Leu Thr Leu Phe Asn Leu Ala Asp Thr Leu Leu Gly Gly Leu Pro 
    370                 375                 380                 


Thr Glu Leu Ile Ser Ser Ala Gly Gly Gln Leu Phe Tyr Ser Arg Pro 
385                 390                 395                 400 


Val Val Ser Ala Asn Gly Glu Pro Thr Val Lys Leu Tyr Thr Ser Val 
                405                 410                 415     


Glu Asn Ala Gln Gln Asp Lys Gly Ile Ala Ile Pro His Asp Ile Asp 
            420                 425                 430         


Leu Gly Glu Ser Arg Val Val Ile Gln Asp Tyr Asp Asn Gln His Glu 
        435                 440                 445             


Gln Asp Arg Pro Thr Pro Ser Pro Ala Pro Ser Arg Pro Phe Ser Val 
    450                 455                 460                 


Leu Arg Ala Asn Asp Val Leu Trp Leu Ser Leu Thr Ala Ala Glu Tyr 
465                 470                 475                 480 


Asp Gln Ser Thr Tyr Gly Ser Ser Thr Gly Pro Val Tyr Val Ser Asp 
                485                 490                 495     


Ser Val Thr Leu Val Asn Val Ala Thr Gly Ala Gln Ala Val Ala Arg 
            500                 505                 510         


Ser Leu Asp Trp Thr Lys Val Thr Leu Asp Gly Arg Pro Leu Ser Thr 
        515                 520                 525             


Ile Gln Gln Tyr Ser Lys Thr Phe Phe Val Leu Pro Leu Arg Gly Lys 
    530                 535                 540                 


Leu Ser Phe Trp Glu Ala Gly Thr Thr Lys Ala Gly Tyr Pro Tyr Asn 
545                 550                 555                 560 


Tyr Asn Thr Thr Ala Ser Asp Gln Leu Leu Val Glu Asn Ala Ala Gly 
                565                 570                 575     


His Arg Val Ala Ile Ser Thr Tyr Thr Thr Ser Leu Gly Ala Gly Pro 
            580                 585                 590         


Val Ser Ile Ser Ala Val Ala Val Leu Ala Pro His Ser Val Leu Ala 
        595                 600                 605             


Leu Leu Glu Asp Thr Met Asp Tyr Pro Ala Arg Ala His Thr Phe Asp 
    610                 615                 620                 


Asp Phe Cys Pro Glu Cys Arg Pro Leu Gly Leu Gln Gly Cys Ala Phe 
625                 630                 635                 640 


Gln Ser Thr Val Ala Glu Leu Gln Arg Leu Lys Met Lys Val Gly Lys 
                645                 650                 655     


Thr Arg Glu Leu 
            660 


<210>  18
<211>  660
<212>  PRT
<213>  Hepatitis E virus


<220>
<221>  misc_feature
<222>  (481)..(481)
<223>  Xaa can be any naturally occurring amino acid

<400>  18

Met Arg Pro Arg Ala Val Leu Leu Leu Phe Leu Met Phe Leu Pro Met 
1               5                   10                  15      


Leu Pro Ala Pro Pro Ala Gly Gln Pro Ser Gly Arg Arg Arg Gly Arg 
            20                  25                  30          


Arg Ser Gly Gly Ala Gly Gly Gly Phe Trp Ser Asp Arg Val Asp Ser 
        35                  40                  45              


Gln Pro Phe Ala Leu Pro Tyr Ile His Pro Thr Asn Pro Phe Ala Ala 
    50                  55                  60                  


Asp Val Val Ser Gln Pro Gly Ala Gly Thr Arg Pro Arg Gln Pro Pro 
65                  70                  75                  80  


Arg Pro Leu Gly Ser Ala Trp Arg Asp Gln Ser Lys Arg Pro Ser Val 
                85                  90                  95      


Ala Pro Arg Arg Arg Ser Thr Pro Ala Gly Ala Ala Pro Leu Thr Ala 
            100                 105                 110         


Ile Ser Pro Ala Pro Asp Thr Ala Pro Val Pro Asp Val Asp Ser Arg 
        115                 120                 125             


Gly Ala Ile Leu Arg Arg Gln Tyr Asn Leu Ser Thr Ser Pro Leu Thr 
    130                 135                 140                 


Ser Ser Val Ala Ser Gly Thr Asn Leu Val Leu Tyr Ala Ala Pro Leu 
145                 150                 155                 160 


Asn Pro Leu Leu Pro Leu Gln Asp Gly Thr Asn Thr His Ile Met Ala 
                165                 170                 175     


Thr Glu Ala Ser Asn Tyr Ala Gln Tyr Arg Val Val Arg Ala Thr Ile 
            180                 185                 190         


Arg Tyr Arg Pro Leu Val Pro Asn Ala Val Gly Gly Tyr Ala Ile Ser 
        195                 200                 205             


Ile Ser Phe Trp Pro Gln Thr Thr Thr Thr Pro Thr Ser Val Asp Met 
    210                 215                 220                 


Asn Ser Ile Thr Ser Thr Asp Val Arg Ile Leu Val Gln Pro Gly Ile 
225                 230                 235                 240 


Ala Ser Glu Leu Val Ile Pro Ser Glu Arg Leu His Tyr Arg Asn Gln 
                245                 250                 255     


Gly Trp Arg Ser Val Glu Thr Thr Gly Val Ala Glu Glu Glu Ala Thr 
            260                 265                 270         


Ser Gly Leu Val Met Leu Cys Ile His Gly Ser Pro Val Asn Ser Tyr 
        275                 280                 285             


Thr Asn Thr Pro Tyr Thr Gly Ala Leu Gly Leu Leu Asp Phe Ala Leu 
    290                 295                 300                 


Glu Leu Glu Phe Arg Asn Leu Thr Pro Gly Asn Thr Asn Thr Arg Val 
305                 310                 315                 320 


Ser Arg Tyr Thr Ser Thr Ala Arg His Arg Leu Arg Arg Gly Ala Asp 
                325                 330                 335     


Gly Thr Ala Glu Leu Thr Thr Thr Ala Ala Thr Arg Phe Met Lys Asp 
            340                 345                 350         


Leu His Phe Thr Gly Thr Asn Gly Val Gly Glu Val Gly Arg Gly Ile 
        355                 360                 365             


Ala Leu Thr Leu Phe Asn Leu Ala Asp Thr Leu Leu Gly Gly Leu Pro 
    370                 375                 380                 


Thr Glu Leu Ile Ser Ser Ala Gly Gly Gln Leu Phe Tyr Ser Arg Pro 
385                 390                 395                 400 


Val Val Ser Ala Asn Gly Glu Pro Thr Val Lys Leu Tyr Thr Ser Val 
                405                 410                 415     


Glu Asn Ala Gln Gln Asp Lys Gly Ile Thr Ile Pro His Asp Ile Asp 
            420                 425                 430         


Leu Gly Asp Ser Arg Val Val Ile Gln Asp Tyr Asp Asn Gln His Glu 
        435                 440                 445             


Gln Asp Arg Pro Thr Pro Ser Pro Ala Pro Ser Arg Pro Phe Ser Val 
    450                 455                 460                 


Leu Arg Ala Asn Asp Val Leu Trp Leu Ser Leu Thr Ala Ala Glu Tyr 
465                 470                 475                 480 


Xaa Gln Thr Thr Tyr Gly Ser Ser Thr Asn Pro Met Tyr Val Ser Asp 
                485                 490                 495     


Thr Val Thr Leu Val Asn Val Ala Thr Gly Ala Gln Ala Val Ala Arg 
            500                 505                 510         


Ser Leu Asp Trp Ser Lys Val Thr Leu Asp Gly Arg Pro Leu Thr Thr 
        515                 520                 525             


Ile Gln Gln Tyr Ser Lys Lys Phe Tyr Val Leu Pro Leu Arg Gly Lys 
    530                 535                 540                 


Leu Ser Phe Trp Glu Ala Gly Thr Thr Lys Ala Gly Tyr Pro Tyr Asn 
545                 550                 555                 560 


Tyr Asn Thr Thr Ala Ser Asp Gln Ile Leu Ile Glu Asn Ala Ala Gly 
                565                 570                 575     


His Arg Val Ala Ile Ser Thr Tyr Thr Thr Ser Leu Gly Ala Gly Pro 
            580                 585                 590         


Thr Ser Ile Ser Ala Val Gly Val Leu Ala Pro His Ser Ala Leu Ala 
        595                 600                 605             


Val Leu Glu Asp Thr Val Asp Tyr Pro Ala Arg Ala His Thr Phe Asp 
    610                 615                 620                 


Asp Phe Cys Pro Glu Cys Arg Thr Leu Gly Leu Gln Gly Cys Ala Phe 
625                 630                 635                 640 


Gln Ser Thr Ile Ala Glu Leu Gln Arg Leu Lys Met Lys Val Gly Lys 
                645                 650                 655     


Thr Arg Glu Ser 
            660 


<210>  19
<211>  660
<212>  PRT
<213>  Hepatitis E virus

<400>  19

Met Arg Pro Arg Ala Val Leu Leu Leu Phe Phe Val Leu Leu Pro Met 
1               5                   10                  15      


Leu Pro Ala Pro Pro Ala Gly Gln Pro Ser Gly Arg Arg Arg Gly Arg 
            20                  25                  30          


Arg Ser Gly Gly Thr Gly Gly Gly Phe Trp Gly Asp Arg Val Asp Ser 
        35                  40                  45              


Gln Pro Phe Ala Leu Pro Tyr Ile His Pro Thr Asn Pro Phe Ala Ser 
    50                  55                  60                  


Asp Ile Pro Thr Ala Thr Gly Ala Gly Ala Arg Pro Arg Gln Pro Ala 
65                  70                  75                  80  


Arg Pro Leu Gly Ser Ala Trp Arg Asp Gln Ser Gln Arg Pro Ala Ala 
                85                  90                  95      


Pro Ala Arg Arg Arg Ser Ala Pro Ala Gly Ala Ser Pro Leu Thr Ala 
            100                 105                 110         


Val Ala Pro Ala Pro Asp Thr Ala Pro Val Pro Asp Val Asp Ser Arg 
        115                 120                 125             


Gly Ala Ile Leu Arg Arg Gln Tyr Asn Leu Ser Thr Ser Pro Leu Thr 
    130                 135                 140                 


Ser Thr Ile Ala Thr Gly Thr Asn Leu Val Leu Tyr Ala Ala Pro Leu 
145                 150                 155                 160 


Ser Pro Leu Leu Pro Leu Gln Asp Gly Thr Asn Thr His Ile Ile Ala 
                165                 170                 175     


Thr Glu Ala Ser Asn Tyr Ala Gln Tyr Arg Val Val Arg Ala Thr Ile 
            180                 185                 190         


Arg Tyr Arg Pro Leu Val Pro Asn Ala Val Gly Gly Tyr Ala Ile Ser 
        195                 200                 205             


Ile Ser Phe Trp Pro Gln Thr Thr Thr Thr Pro Thr Ser Val Asp Met 
    210                 215                 220                 


Asn Ser Ile Thr Ser Thr Asp Val Arg Ile Leu Val Gln Pro Gly Ile 
225                 230                 235                 240 


Ala Ser Glu Leu Val Ile Pro Ser Glu Arg Leu His Tyr Arg Asn Gln 
                245                 250                 255     


Gly Trp Arg Ser Val Glu Thr Ser Gly Val Ala Glu Glu Glu Ala Thr 
            260                 265                 270         


Ser Gly Leu Val Met Leu Cys Ile His Gly Ser Pro Val Asn Ser Tyr 
        275                 280                 285             


Thr Asn Thr Pro Tyr Thr Gly Ala Leu Gly Leu Leu Asp Phe Ala Leu 
    290                 295                 300                 


Glu Leu Glu Phe Arg Asn Leu Thr Pro Gly Asn Thr Asn Thr Arg Val 
305                 310                 315                 320 


Ser Arg Tyr Ser Ser Ser Ala Arg His Lys Leu Cys Arg Gly Pro Asp 
                325                 330                 335     


Gly Thr Ala Glu Leu Thr Thr Thr Ala Ala Thr Arg Phe Met Lys Asp 
            340                 345                 350         


Leu His Phe Thr Gly Thr Asn Gly Val Gly Glu Val Gly Arg Gly Ile 
        355                 360                 365             


Ala Leu Thr Leu Leu Asn Leu Ala Asp Thr Leu Leu Gly Gly Leu Pro 
    370                 375                 380                 


Thr Glu Leu Ile Ser Ser Ala Gly Gly Gln Leu Phe Tyr Ser Arg Pro 
385                 390                 395                 400 


Val Val Ser Ala Asn Gly Glu Pro Thr Val Lys Leu Tyr Thr Ser Val 
                405                 410                 415     


Glu Asn Ala Gln Gln Asp Lys Gly Ile Ala Ile Pro His Asp Ile Asp 
            420                 425                 430         


Leu Gly Glu Ser Arg Val Val Ile Gln Asp Tyr Asp Asn Gln His Glu 
        435                 440                 445             


Gln Asp Arg Pro Thr Pro Ser Pro Ala Pro Ser Arg Pro Phe Ser Val 
    450                 455                 460                 


Leu Arg Ala Asn Asp Val Leu Trp Leu Ser Leu Thr Ala Ala Glu Tyr 
465                 470                 475                 480 


Asp Gln Thr Thr Tyr Gly Ser Ser Thr Asn Pro Met Tyr Val Ser Asp 
                485                 490                 495     


Thr Val Thr Phe Val Asn Val Ala Thr Gly Thr Gln Gly Val Ser Arg 
            500                 505                 510         


Ser Leu Asp Trp Ser Lys Val Thr Leu Asp Gly Arg Pro Leu Thr Thr 
        515                 520                 525             


Ile Gln Gln Tyr Ser Lys Thr Phe Phe Val Leu Pro Leu Arg Gly Lys 
    530                 535                 540                 


Leu Ser Phe Trp Glu Ala Gly Thr Thr Lys Ala Gly Tyr Pro Tyr Asn 
545                 550                 555                 560 


Tyr Asn Thr Thr Ala Ser Asp Gln Ile Leu Ile Glu Asn Ala Pro Gly 
                565                 570                 575     


His Arg Val Cys Ile Ser Thr Tyr Thr Thr Asn Leu Gly Ser Gly Pro 
            580                 585                 590         


Val Ser Ile Ser Ala Val Gly Val Leu Ala Pro His Ser Ala Leu Ala 
        595                 600                 605             


Ala Leu Glu Asp Thr Val Asp Tyr Pro Ala Arg Ala His Thr Phe Asp 
    610                 615                 620                 


Asp Phe Cys Pro Glu Cys Arg Ala Leu Gly Leu Gln Gly Cys Ala Phe 
625                 630                 635                 640 


Gln Ser Thr Val Ala Glu Leu Gln Arg Leu Lys Met Lys Val Gly Lys 
                645                 650                 655     


Thr Gln Glu Tyr 
            660 


<210>  20
<211>  660
<212>  PRT
<213>  Hepatitis E virus

<400>  20

Met Arg Pro Arg Pro Ile Leu Leu Leu Leu Leu Met Phe Leu Pro Met 
1               5                   10                  15      


Leu Pro Ala Pro Pro Pro Gly Gln Pro Ser Gly Arg Arg Arg Gly Arg 
            20                  25                  30          


Arg Ser Gly Gly Ser Gly Gly Gly Phe Trp Gly Asp Arg Val Asp Ser 
        35                  40                  45              


Gln Pro Phe Ala Ile Pro His Ile His Pro Thr Asn Pro Phe Ala Pro 
    50                  55                  60                  


Asp Val Thr Ala Ala Ala Gly Ala Gly Pro Arg Val Arg Gln Pro Ala 
65                  70                  75                  80  


Arg Pro Leu Gly Ser Ala Trp Arg Asp Gln Ala Gln Arg Pro Ala Ala 
                85                  90                  95      


Thr Ser Arg Arg Arg Pro Thr Thr Ala Gly Ala Ala Pro Leu Thr Ala 
            100                 105                 110         


Val Ala Pro Ala His Asp Thr Pro Pro Val Pro Asp Val Asp Ser Arg 
        115                 120                 125             


Gly Ala Ile Leu Arg Arg Gln Tyr Asn Leu Ser Thr Ser Pro Leu Thr 
    130                 135                 140                 


Ser Pro Val Ala Thr Gly Thr Asn Leu Val Leu Tyr Ala Ala Pro Leu 
145                 150                 155                 160 


Ser Pro Leu Leu Pro Leu Gln Asp Gly Thr Asn Thr His Ile Met Ala 
                165                 170                 175     


Thr Glu Ala Ser Asn Tyr Ala Gln Tyr Arg Val Ala Arg Ala Thr Ile 
            180                 185                 190         


Arg Tyr Arg Pro Leu Val Pro Asn Ala Val Gly Gly Tyr Ala Ile Ser 
        195                 200                 205             


Ile Ser Phe Trp Pro Gln Thr Thr Thr Thr Pro Thr Ser Val Asp Met 
    210                 215                 220                 


Asn Ser Ile Thr Ser Thr Asp Val Arg Ile Leu Val Gln Pro Gly Ile 
225                 230                 235                 240 


Ala Ser Glu Leu Val Ile Pro Ser Glu Arg Leu His Tyr Arg Asn Gln 
                245                 250                 255     


Gly Trp Arg Ser Val Glu Thr Ser Gly Val Ala Glu Glu Glu Ala Thr 
            260                 265                 270         


Ser Gly Leu Val Met Leu Cys Ile His Gly Leu Pro Val Asn Ser Tyr 
        275                 280                 285             


Thr Asn Thr Pro Tyr Thr Gly Ala Leu Gly Leu Leu Asp Phe Ala Leu 
    290                 295                 300                 


Glu Phe Glu Phe Arg Asn Leu Thr Pro Gly Asn Thr Asn Thr Arg Val 
305                 310                 315                 320 


Ser Arg Tyr Ser Ser Thr Ala Arg His Arg Leu Arg Arg Gly Ala Asp 
                325                 330                 335     


Gly Thr Ala Glu Leu Thr Thr Thr Ala Ala Thr Arg Phe Met Lys Asp 
            340                 345                 350         


Leu Tyr Phe Thr Ser Thr Asn Gly Val Gly Glu Ile Gly Arg Gly Ile 
        355                 360                 365             


Ala Leu Thr Leu Phe Asn Leu Ala Asp Thr Leu Leu Gly Gly Leu Pro 
    370                 375                 380                 


Thr Glu Leu Ile Ser Ser Ala Gly Gly Gln Leu Phe Tyr Ser Arg Pro 
385                 390                 395                 400 


Val Val Ser Ala Asn Gly Glu Pro Thr Val Lys Leu Tyr Thr Ser Val 
                405                 410                 415     


Glu Asn Ala Gln Gln Asp Lys Gly Ile Ala Ile Pro His Asp Ile Asp 
            420                 425                 430         


Leu Gly Glu Ser Arg Val Val Ile Gln Asp Tyr Asp Asn Gln His Glu 
        435                 440                 445             


Gln Asp Arg Pro Thr Pro Ser Pro Ala Pro Ser Arg Pro Phe Ser Val 
    450                 455                 460                 


Leu Arg Ala Asn Asp Val Leu Trp Leu Ser Leu Thr Ala Ala Glu Tyr 
465                 470                 475                 480 


Asp Gln Ser Thr Tyr Gly Ser Ser Thr Gly Pro Val Tyr Val Ser Asp 
                485                 490                 495     


Ser Val Thr Leu Val Asn Val Ala Thr Gly Ala Gln Ala Val Ala Arg 
            500                 505                 510         


Ser Leu Asp Trp Thr Lys Val Thr Leu Asp Gly Arg Pro Leu Ser Thr 
        515                 520                 525             


Ile Gln Gln Tyr Ser Lys Thr Phe Phe Val Leu Pro Leu Arg Gly Lys 
    530                 535                 540                 


Leu Ser Phe Trp Glu Ala Gly Thr Thr Lys Ala Gly Tyr Pro Tyr Asn 
545                 550                 555                 560 


Tyr Asn Thr Thr Ala Ser Asp Gln Leu Leu Ile Glu Asn Ala Ala Gly 
                565                 570                 575     


His Arg Val Ala Ile Ser Thr Tyr Thr Thr Ser Leu Gly Ala Gly Pro 
            580                 585                 590         


Val Ala Ile Ser Ala Val Ala Val Leu Ala Pro His Ser Ala Leu Ala 
        595                 600                 605             


Leu Leu Glu Asp Thr Met Asp Tyr Pro Ala Arg Ala His Thr Phe Asp 
    610                 615                 620                 


Asp Phe Cys Pro Glu Cys Arg Pro Leu Gly Leu Gln Gly Cys Ala Phe 
625                 630                 635                 640 


Gln Ser Thr Val Ala Glu Leu Gln Arg Leu Lys Met Lys Val Gly Lys 
                645                 650                 655     


Thr Arg Glu Leu 
            660 


<210>  21
<211>  660
<212>  PRT
<213>  Hepatitis E virus

<400>  21

Met Arg Pro Arg Ala Val Leu Leu Leu Phe Phe Val Leu Leu Pro Met 
1               5                   10                  15      


Leu Pro Ala Pro Pro Ala Gly Gln Pro Ser Gly Arg Arg Arg Gly Arg 
            20                  25                  30          


Arg Ser Gly Gly Ala Gly Gly Gly Phe Trp Gly Asp Arg Val Asp Ser 
        35                  40                  45              


Gln Pro Phe Ala Leu Pro Tyr Ile His Pro Thr Asn Pro Phe Ala Ala 
    50                  55                  60                  


Asp Val Ala Ser Gln Ser Gly Ala Gly Ala Arg Pro Arg Gln Pro Pro 
65                  70                  75                  80  


Arg Pro Leu Gly Ser Ala Trp Arg Asp Gln Ser Gln Arg Pro Pro Ala 
                85                  90                  95      


Val Pro Arg Arg Arg Ser Ala Pro Ala Gly Ala Ala Pro Leu Thr Ala 
            100                 105                 110         


Ile Ser Pro Ala Pro Asp Thr Ala Pro Val Pro Asp Val Asp Ser Arg 
        115                 120                 125             


Gly Ala Ile Leu Arg Arg Gln Tyr Asn Leu Ser Thr Ser Pro Leu Thr 
    130                 135                 140                 


Ser Ser Val Ala Ser Gly Thr Asn Leu Val Leu Tyr Ala Ala Pro Leu 
145                 150                 155                 160 


Asn Pro Leu Leu Pro Leu Gln Asp Gly Thr Asn Thr His Ile Met Ala 
                165                 170                 175     


Thr Glu Ala Ser Asn Tyr Ala Gln Tyr Arg Val Val Arg Ala Thr Ile 
            180                 185                 190         


Arg Tyr Arg Pro Leu Val Pro Asn Ala Val Gly Gly Tyr Ala Ile Ser 
        195                 200                 205             


Ile Ser Phe Trp Pro Gln Thr Thr Thr Thr Pro Thr Ser Val Asp Met 
    210                 215                 220                 


Asn Ser Ile Thr Ser Thr Asp Val Arg Ile Leu Val Gln Pro Gly Ile 
225                 230                 235                 240 


Ala Ser Glu Leu Val Ile Pro Ser Glu Arg Leu His Tyr Arg Asn Gln 
                245                 250                 255     


Gly Trp Arg Ser Val Glu Thr Thr Gly Val Ala Glu Glu Glu Ala Thr 
            260                 265                 270         


Ser Gly Leu Val Met Leu Cys Ile His Gly Ser Pro Val Asn Ser Tyr 
        275                 280                 285             


Thr Asn Thr Pro Tyr Thr Gly Ala Leu Gly Leu Leu Asp Phe Ala Leu 
    290                 295                 300                 


Glu Leu Glu Phe Arg Asn Leu Thr Pro Gly Asn Thr Asn Thr Arg Val 
305                 310                 315                 320 


Ser Arg Tyr Thr Ser Thr Ala Arg His Arg Leu Arg Arg Gly Ala Asp 
                325                 330                 335     


Gly Thr Ala Glu Leu Thr Thr Thr Ala Ala Thr Arg Phe Met Lys Asp 
            340                 345                 350         


Leu His Phe Thr Gly Thr Asn Gly Val Gly Glu Val Gly Arg Gly Ile 
        355                 360                 365             


Ala Leu Thr Leu Phe Asn Leu Ala Asp Thr Leu Leu Gly Gly Leu Pro 
    370                 375                 380                 


Thr Glu Leu Ile Ser Ser Ala Gly Gly Gln Leu Phe Tyr Ser Arg Pro 
385                 390                 395                 400 


Val Ala Ser Ala Asn Gly Glu Pro Thr Val Lys Leu Tyr Thr Ser Val 
                405                 410                 415     


Glu Asn Ala Gln Gln Asp Lys Gly Ile Thr Ile Pro His Asp Ile Asp 
            420                 425                 430         


Leu Gly Asp Ser Arg Val Val Ile Gln Asp Tyr Asp Asn Gln His Glu 
        435                 440                 445             


Gln Asp Arg Pro Thr Pro Ser Pro Ala Pro Ser Arg Pro Phe Ser Val 
    450                 455                 460                 


Leu Arg Ala Asn Asp Val Leu Trp Leu Ser Leu Thr Val Ala Glu Tyr 
465                 470                 475                 480 


Asp Gln Thr Thr Tyr Gly Ser Ser Thr Asn Pro Met Tyr Val Ser Asp 
                485                 490                 495     


Thr Ala Thr Phe Val Asn Val Ala Thr Gly Ala Gln Ala Val Ala Arg 
            500                 505                 510         


Ser Leu Asp Trp Ser Lys Val Thr Leu Asp Gly Arg Pro Leu Thr Thr 
        515                 520                 525             


Ile Gln Gln Tyr Ser Lys Thr Phe Tyr Val Leu Pro Leu Arg Gly Lys 
    530                 535                 540                 


Leu Ser Phe Trp Glu Ala Gly Thr Thr Lys Ala Gly Tyr Pro Tyr Asn 
545                 550                 555                 560 


Tyr Asn Thr Ala Ala Ser Asp Gln Ile Leu Ile Glu Asn Ala Ala Gly 
                565                 570                 575     


His Arg Val Ala Ile Ser Thr Tyr Thr Thr Ser Leu Gly Ala Ser Pro 
            580                 585                 590         


Thr Ser Ile Ser Ala Val Gly Val Leu Ala Pro His Ser Ala Leu Ala 
        595                 600                 605             


Val Leu Glu Asp Thr Val Asp Tyr Pro Ala Arg Ala His Thr Phe Asp 
    610                 615                 620                 


Asp Phe Cys Pro Glu Cys Arg Thr Leu Gly Leu Gln Gly Cys Ala Phe 
625                 630                 635                 640 


Gln Ser Thr Ile Ala Glu Leu Gln Arg Leu Lys Met Lys Val Gly Lys 
                645                 650                 655     


Thr Arg Glu Ser 
            660 


<210>  22
<211>  660
<212>  PRT
<213>  Hepatitis E virus

<400>  22

Met Arg Pro Arg Ala Val Leu Leu Leu Leu Phe Val Leu Leu Pro Met 
1               5                   10                  15      


Leu Pro Ala Pro Pro Ala Gly Gln Pro Ser Gly Arg Arg Arg Gly Arg 
            20                  25                  30          


Arg Ser Gly Gly Ala Gly Gly Gly Phe Trp Gly Asp Arg Val Asp Ser 
        35                  40                  45              


Gln Pro Phe Ala Leu Pro Tyr Ile His Pro Thr Asn Pro Phe Ala Ala 
    50                  55                  60                  


Asp Val Val Ser Gln Pro Gly Ala Gly Thr Arg Pro Arg Gln Pro Pro 
65                  70                  75                  80  


Arg Pro Leu Gly Ser Ala Trp Arg Asp Gln Ser Gln Arg Pro Ser Ala 
                85                  90                  95      


Ala Pro Arg Arg Arg Pro Ala Pro Ala Gly Ala Thr Pro Leu Thr Ala 
            100                 105                 110         


Val Ser Pro Ala Pro Asp Ala Ala Pro Val Pro Asp Val Asp Ser Arg 
        115                 120                 125             


Gly Ala Ile Leu Arg Arg Gln Tyr Asn Leu Ser Thr Ser Pro Leu Thr 
    130                 135                 140                 


Ser Ser Val Ala Ser Gly Thr Asn Leu Val Leu Tyr Ala Ala Pro Leu 
145                 150                 155                 160 


Asn Pro Leu Leu Pro Leu Gln Asp Gly Thr Asn Thr His Ile Met Ala 
                165                 170                 175     


Thr Glu Ala Ser Asn Tyr Ala Gln Tyr Arg Val Val Arg Ala Thr Ile 
            180                 185                 190         


Arg Tyr Arg Pro Leu Val Pro Asn Ala Val Gly Gly Tyr Ala Val Ser 
        195                 200                 205             


Ile Ser Phe Trp Pro Gln Thr Thr Thr Thr Pro Thr Ser Val Asp Met 
    210                 215                 220                 


Asn Ser Ile Thr Ser Thr Asp Val Arg Ile Leu Val Gln Pro Gly Val 
225                 230                 235                 240 


Ala Ser Glu Leu Val Ile Pro Ser Glu Arg Leu His Tyr Arg Asn Gln 
                245                 250                 255     


Gly Trp Arg Ser Val Glu Thr Thr Gly Val Ala Glu Glu Glu Ala Thr 
            260                 265                 270         


Ser Gly Leu Val Met Leu Cys Ile His Gly Ser Pro Val Asn Ser Tyr 
        275                 280                 285             


Thr Asn Thr Pro Tyr Thr Gly Ala Leu Gly Leu Leu Asp Phe Ala Leu 
    290                 295                 300                 


Glu Leu Glu Phe Arg Asn Leu Thr Pro Gly Asn Thr Asn Thr Arg Val 
305                 310                 315                 320 


Ser Arg Tyr Thr Ser Thr Ala Arg His Arg Leu Arg Arg Gly Ala Asp 
                325                 330                 335     


Gly Thr Ala Glu Leu Thr Thr Thr Ala Ala Thr Arg Phe Met Lys Asp 
            340                 345                 350         


Leu His Phe Thr Gly Thr Asn Gly Val Gly Glu Val Gly Arg Gly Ile 
        355                 360                 365             


Ala Leu Thr Leu Phe Asn Leu Ala Asp Thr Leu Leu Gly Gly Leu Pro 
    370                 375                 380                 


Thr Glu Leu Ile Ser Ser Ala Gly Gly Gln Leu Phe Tyr Ser Arg Pro 
385                 390                 395                 400 


Val Val Ser Ala Asn Gly Glu Pro Thr Val Lys Leu Tyr Thr Ser Val 
                405                 410                 415     


Glu Asn Ala Gln Gln Asp Lys Gly Ile Thr Ile Pro His Asp Ile Asp 
            420                 425                 430         


Leu Gly Asp Ser Arg Val Val Ile Gln Asp Tyr Asp Asn Gln His Glu 
        435                 440                 445             


Gln Asp Arg Pro Thr Pro Ser Pro Ala Pro Ser Arg Pro Phe Ser Val 
    450                 455                 460                 


Leu Arg Ala Asn Asp Val Leu Trp Leu Ser Leu Thr Ala Ala Glu Tyr 
465                 470                 475                 480 


Asp Gln Thr Thr Tyr Gly Ser Ser Thr Asn Pro Met Tyr Val Ser Asp 
                485                 490                 495     


Thr Val Thr Leu Val Asn Val Ala Thr Gly Ala Gln Ala Val Ala Arg 
            500                 505                 510         


Ser Leu Asp Trp Ser Lys Val Thr Leu Asp Gly Arg Pro Leu Thr Thr 
        515                 520                 525             


Ile Gln Gln Tyr Ser Lys Thr Phe Tyr Val Leu Pro Leu Arg Gly Lys 
    530                 535                 540                 


Leu Ser Phe Trp Glu Ala Gly Thr Thr Lys Ala Gly Tyr Pro Tyr Asn 
545                 550                 555                 560 


Tyr Asn Thr Thr Ala Ser Asp Gln Ile Leu Ile Glu Asn Ala Ser Gly 
                565                 570                 575     


His Arg Val Ala Ile Ser Thr Tyr Thr Thr Ser Leu Gly Ala Gly Pro 
            580                 585                 590         


Thr Ser Ile Ser Ala Val Gly Val Leu Ala Pro His Ser Ala Leu Ala 
        595                 600                 605             


Val Leu Glu Asp Thr Ile Asp Tyr Pro Ala Arg Ala His Thr Phe Asp 
    610                 615                 620                 


Asp Phe Cys Pro Glu Cys Arg Ala Leu Gly Phe Gln Gly Cys Ala Phe 
625                 630                 635                 640 


Gln Ser Thr Ile Ala Glu Leu Gln Arg Leu Lys Met Lys Val Gly Lys 
                645                 650                 655     


Thr Arg Glu Ser 
            660 


<210>  23
<211>  660
<212>  PRT
<213>  Hepatitis E virus

<400>  23

Met Cys Pro Arg Ala Val Leu Leu Leu Leu Phe Val Leu Leu Pro Met 
1               5                   10                  15      


Leu Pro Ala Pro Pro Ala Gly Gln Pro Ser Gly Arg Arg Arg Gly Arg 
            20                  25                  30          


Arg Ser Gly Gly Ala Gly Gly Gly Phe Trp Gly Asp Arg Val Asp Ser 
        35                  40                  45              


Gln Pro Phe Ala Leu Pro Tyr Ile His Pro Thr Asn Pro Phe Ala Ala 
    50                  55                  60                  


Asp Val Phe Ser Gln Ser Gly Ala Gly Ala Arg Pro Arg Gln Pro Pro 
65                  70                  75                  80  


Arg Pro Leu Gly Ser Ala Trp Arg Asp Gln Ser Gln Arg Pro Ser Ala 
                85                  90                  95      


Ala Pro Arg Arg Arg Ser Thr Pro Ala Gly Ala Ala Pro Leu Thr Ala 
            100                 105                 110         


Thr Ser Pro Ala Pro Asp Thr Ala Pro Val Pro Asp Val Asp Ser Arg 
        115                 120                 125             


Gly Ala Ile Leu Arg Arg Gln Tyr Asn Leu Ser Thr Ser Pro Leu Thr 
    130                 135                 140                 


Ser Ser Val Ala Ser Gly Thr Asn Leu Val Leu Tyr Ala Ala Pro Leu 
145                 150                 155                 160 


Asn Pro Leu Leu Pro Leu Gln Asp Gly Thr Asn Thr His Ile Met Ala 
                165                 170                 175     


Thr Glu Ala Ser Asn Tyr Ala Gln Tyr Arg Val Val Arg Ala Thr Ile 
            180                 185                 190         


Arg Tyr Arg Pro Leu Val Pro Asn Ala Val Gly Gly Tyr Ala Ile Ser 
        195                 200                 205             


Ile Ser Phe Trp Pro Gln Thr Thr Thr Thr Pro Thr Ser Val Asp Met 
    210                 215                 220                 


Asn Ser Ile Thr Ser Thr Asp Val Arg Ile Leu Val Gln Pro Gly Ile 
225                 230                 235                 240 


Ala Ser Glu Leu Val Ile Pro Ser Glu Arg Leu His Tyr Arg Asn Gln 
                245                 250                 255     


Gly Trp Arg Ser Val Glu Thr Thr Gly Val Ala Glu Glu Glu Ala Thr 
            260                 265                 270         


Ser Gly Leu Val Met Leu Cys Ile His Gly Ser Pro Val Asn Ser Tyr 
        275                 280                 285             


Thr Asn Thr Pro Tyr Thr Gly Ala Leu Gly Leu Leu Asp Phe Ala Leu 
    290                 295                 300                 


Glu Leu Glu Phe Arg Asn Leu Thr Pro Gly Asn Thr Asn Thr Arg Val 
305                 310                 315                 320 


Ser Arg Tyr Thr Ser Thr Ala Arg His Arg Leu Arg Arg Gly Ala Asp 
                325                 330                 335     


Gly Thr Ala Glu Leu Thr Thr Thr Ala Ala Thr Arg Phe Met Lys Asp 
            340                 345                 350         


Leu His Phe Thr Gly Thr Asn Gly Val Gly Glu Val Gly Arg Gly Ile 
        355                 360                 365             


Ala Leu Thr Leu Phe Asn Leu Ala Asp Thr Leu Leu Gly Gly Leu Pro 
    370                 375                 380                 


Thr Glu Leu Ile Ser Ser Ala Gly Gly Gln Leu Phe Tyr Ser Arg Pro 
385                 390                 395                 400 


Val Val Ser Ala Asn Gly Glu Pro Thr Val Lys Leu Tyr Thr Ser Val 
                405                 410                 415     


Glu Asn Ala Gln Gln Asp Lys Gly Ile Thr Ile Pro His Asp Ile Asp 
            420                 425                 430         


Leu Gly Asp Ser Arg Val Val Ile Gln Asp Tyr Asp Asn Gln His Glu 
        435                 440                 445             


Gln Asp Arg Pro Thr Pro Ser Pro Ala Pro Ser Arg Pro Phe Ser Val 
    450                 455                 460                 


Leu Arg Ala Asn Asp Val Leu Trp Leu Ser Leu Thr Ala Ala Glu Tyr 
465                 470                 475                 480 


Asp Gln Thr Thr Tyr Gly Ser Ser Thr Asn Pro Met Tyr Val Ser Asp 
                485                 490                 495     


Thr Val Thr Phe Val Asn Val Ala Thr Gly Ala Gln Ala Val Ala Arg 
            500                 505                 510         


Ser Leu Asp Trp Ser Lys Val Thr Leu Asp Gly Arg Pro Leu Thr Thr 
        515                 520                 525             


Ile Gln Gln Tyr Ser Lys Thr Phe Tyr Val Leu Pro Leu Arg Gly Lys 
    530                 535                 540                 


Leu Ser Phe Trp Glu Ala Gly Thr Thr Lys Ala Gly Tyr Pro Tyr Asn 
545                 550                 555                 560 


Tyr Asn Thr Thr Ala Ser Asp Gln Ile Leu Ile Glu Asn Ala Ala Gly 
                565                 570                 575     


His Arg Val Ala Ile Ser Thr Tyr Thr Thr Ser Leu Gly Ala Gly Pro 
            580                 585                 590         


Thr Ser Ile Ser Ala Val Gly Val Leu Ala Pro His Ser Ala Leu Ala 
        595                 600                 605             


Val Leu Glu Asp Thr Val Asp Tyr Pro Ala Arg Ala His Thr Phe Asp 
    610                 615                 620                 


Asp Phe Cys Pro Glu Cys Arg Ala Leu Gly Leu Gln Gly Cys Ala Phe 
625                 630                 635                 640 


Gln Ser Thr Val Ala Glu Leu Gln Arg Leu Lys Met Lys Val Gly Lys 
                645                 650                 655     


Thr Arg Glu Ser 
            660 


<210>  24
<211>  659
<212>  PRT
<213>  Hepatitis E virus

<400>  24

Met Arg Pro Arg Pro Leu Leu Leu Leu Phe Leu Leu Phe Leu Pro Met 
1               5                   10                  15      


Leu Pro Ala Pro Pro Thr Gly Gln Pro Ser Gly Arg Arg Arg Gly Arg 
            20                  25                  30          


Arg Ser Gly Gly Thr Gly Gly Gly Phe Trp Gly Asp Arg Val Asp Ser 
        35                  40                  45              


Gln Pro Phe Ala Ile Pro Tyr Ile His Pro Thr Asn Pro Phe Ala Pro 
    50                  55                  60                  


Asp Val Ala Ala Ala Ser Gly Ser Gly Pro Arg Leu Arg Gln Pro Ala 
65                  70                  75                  80  


Arg Pro Leu Gly Ser Thr Trp Arg Asp Gln Ala Gln Arg Pro Ser Ala 
                85                  90                  95      


Ala Ser Arg Arg Arg Pro Ala Thr Ala Gly Ala Ala Ala Leu Thr Ala 
            100                 105                 110         


Val Ala Pro Ala His Asp Thr Ser Pro Val Pro Asp Val Asp Ser Arg 
        115                 120                 125             


Gly Ala Ile Leu Arg Arg Gln Tyr Asn Leu Ser Thr Ser Pro Leu Thr 
    130                 135                 140                 


Ser Ser Val Ala Ser Gly Thr Asn Leu Val Leu Tyr Ala Ala Pro Leu 
145                 150                 155                 160 


Asn Pro Pro Leu Pro Leu Gln Asp Gly Thr Asn Thr His Ile Met Ala 
                165                 170                 175     


Thr Glu Ala Ser Asn Tyr Ala Gln Tyr Arg Val Ala Arg Ala Thr Ile 
            180                 185                 190         


Arg Tyr Arg Pro Leu Val Pro Asn Ala Val Gly Gly Tyr Ala Ile Ser 
        195                 200                 205             


Ile Ser Phe Trp Pro Gln Thr Thr Thr Thr Pro Thr Ser Val Asp Met 
    210                 215                 220                 


Asn Ser Ile Thr Ser Thr Asp Val Arg Ile Leu Val Gln Pro Gly Ile 
225                 230                 235                 240 


Ala Ser Glu Leu Val Ile Pro Ser Glu Arg Leu His Tyr Arg Asn Gln 
                245                 250                 255     


Gly Trp Arg Ser Val Glu Thr Ser Gly Val Ala Glu Glu Glu Ala Thr 
            260                 265                 270         


Ser Gly Leu Val Met Leu Cys Ile His Gly Ser Pro Val Asn Ser Tyr 
        275                 280                 285             


Thr Asn Thr Pro Tyr Thr Gly Ala Leu Gly Leu Leu Asp Phe Ala Leu 
    290                 295                 300                 


Glu Leu Glu Phe Arg Asn Leu Thr Thr Cys Asn Thr Asn Thr Arg Val 
305                 310                 315                 320 


Ser Arg Tyr Ser Ser Thr Ala Arg His Ser Ala Arg Gly Ala Asp Gly 
                325                 330                 335     


Thr Ala Glu Leu Thr Thr Thr Ala Ala Thr Arg Phe Met Lys Asp Leu 
            340                 345                 350         


His Phe Thr Gly Leu Asn Gly Val Gly Glu Val Gly Arg Gly Ile Ala 
        355                 360                 365             


Leu Thr Leu Leu Asn Leu Ala Asp Thr Leu Leu Gly Gly Leu Pro Thr 
    370                 375                 380                 


Glu Leu Ile Ser Ser Ala Gly Gly Gln Leu Phe Tyr Ser Arg Pro Val 
385                 390                 395                 400 


Val Ser Ala Asn Gly Glu Pro Thr Val Lys Leu Tyr Thr Ser Val Glu 
                405                 410                 415     


Asn Ala Gln Gln Asp Lys Gly Val Ala Ile Pro His Asp Ile Asp Leu 
            420                 425                 430         


Gly Asp Ser Arg Val Val Ile Gln Asp Tyr Asp Asn Gln His Glu Gln 
        435                 440                 445             


Asp Arg Pro Thr Pro Ser Pro Ala Pro Ser Arg Pro Phe Ser Val Leu 
    450                 455                 460                 


Arg Ala Asn Asp Val Leu Trp Leu Ser Leu Thr Ala Ala Glu Tyr Asp 
465                 470                 475                 480 


Gln Ser Thr Tyr Gly Ser Ser Thr Gly Pro Val Tyr Ile Ser Asp Ser 
                485                 490                 495     


Val Thr Leu Val Asn Val Ala Thr Gly Ala Gln Ala Val Ala Arg Ser 
            500                 505                 510         


Leu Asp Trp Ser Lys Val Thr Leu Asp Gly Arg Pro Leu Pro Thr Val 
        515                 520                 525             


Glu Gln Tyr Ser Lys Thr Phe Phe Val Leu Pro Leu Arg Gly Lys Leu 
    530                 535                 540                 


Ser Phe Trp Glu Ala Gly Thr Thr Lys Ala Gly Tyr Pro Tyr Asn Tyr 
545                 550                 555                 560 


Asn Thr Thr Ala Ser Asp Gln Ile Leu Ile Glu Asn Ala Ala Gly His 
                565                 570                 575     


Arg Val Ala Ile Ser Thr Tyr Thr Thr Arg Leu Gly Ala Gly Pro Val 
            580                 585                 590         


Ala Ile Ser Ala Ala Ala Val Leu Ala Pro Arg Ser Ala Leu Ala Leu 
        595                 600                 605             


Leu Glu Asp Thr Phe Asp Tyr Pro Gly Arg Ala His Thr Phe Asp Asp 
    610                 615                 620                 


Phe Cys Pro Glu Cys Arg Ala Leu Gly Leu Gln Gly Cys Ala Phe Gln 
625                 630                 635                 640 


Ser Thr Val Ala Glu Leu Gln Arg Leu Lys Val Lys Val Gly Lys Thr 
                645                 650                 655     


Arg Glu Leu 
            


<210>  25
<211>  12
<212>  PRT
<213>  artificial sequence

<220>
<223>  HEV peptide


<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  X reprsente P, T, S ou A

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  X reprsente L ou F

<400>  25

Cys Pro Glu Cys Arg Xaa Leu Gly Xaa Gln Gly Cys 
1               5                   10          


<210>  26
<211>  267
<212>  PRT
<213>  Hepatitis E virus

<400>  26

Gln Leu Phe Tyr Ser Arg Pro Val Val Ser Ala Asn Gly Glu Pro Thr 
1               5                   10                  15      


Val Lys Leu Tyr Thr Ser Val Glu Asn Ala Gln Gln Asp Lys Gly Ile 
            20                  25                  30          


Ala Ile Pro His Asp Ile Asp Leu Gly Glu Ser Arg Val Val Ile Gln 
        35                  40                  45              


Asp Tyr Asp Asn Gln His Glu Gln Asp Arg Pro Thr Pro Ser Pro Ala 
    50                  55                  60                  


Pro Ser Arg Pro Phe Ser Val Leu Arg Ala Asn Asp Val Leu Trp Leu 
65                  70                  75                  80  


Ser Leu Thr Ala Ala Glu Tyr Asp Gln Ser Thr Tyr Gly Ser Ser Thr 
                85                  90                  95      


Gly Pro Val Tyr Val Ser Asp Ser Val Thr Leu Val Asn Val Ala Thr 
            100                 105                 110         


Gly Ala Gln Ala Val Ala Arg Ser Leu Asp Trp Thr Lys Val Thr Leu 
        115                 120                 125             


Asp Gly Arg Pro Leu Ser Thr Thr Gln Gln Tyr Ser Lys Thr Phe Phe 
    130                 135                 140                 


Val Leu Pro Leu Arg Gly Lys Leu Ser Phe Trp Glu Ala Gly Thr Thr 
145                 150                 155                 160 


Lys Ala Gly Tyr Pro Tyr Asn Tyr Asn Thr Thr Ala Ser Asp Gln Leu 
                165                 170                 175     


Leu Val Glu Asn Ala Ala Gly His Arg Val Ala Ile Ser Thr Tyr Thr 
            180                 185                 190         


Thr Ser Leu Gly Ala Gly Pro Val Ser Ile Ser Ala Val Ala Val Leu 
        195                 200                 205             


Ala Pro His Ser Ala Leu Ala Leu Leu Glu Asp Thr Met Asp Tyr Pro 
    210                 215                 220                 


Ala Arg Ala His Thr Phe Asp Asp Phe Cys Pro Glu Cys Arg Pro Leu 
225                 230                 235                 240 


Gly Leu Gln Gly Cys Ala Phe Gln Ser Thr Val Ala Glu Leu Gln Arg 
                245                 250                 255     


Leu Lys Met Lys Val Gly Lys Thr Arg Glu Leu 
            260                 265         


<210>  27
<211>  267
<212>  PRT
<213>  artificial sequence

<220>
<223>  HEV Peptide mut

<400>  27

Gln Leu Phe Tyr Ser Arg Pro Val Val Ser Ala Asn Gly Glu Pro Thr 
1               5                   10                  15      


Val Lys Leu Tyr Thr Ser Val Glu Asn Ala Gln Gln Asp Lys Gly Ile 
            20                  25                  30          


Ala Ile Pro His Asp Ile Asp Leu Gly Glu Ser Arg Val Val Ile Gln 
        35                  40                  45              


Asp Tyr Asp Asn Gln His Glu Gln Asp Arg Pro Thr Pro Ser Pro Ala 
    50                  55                  60                  


Pro Ser Arg Pro Phe Ser Val Leu Arg Ala Asn Asp Val Leu Trp Leu 
65                  70                  75                  80  


Ser Leu Thr Ala Ala Glu Tyr Asp Gln Ser Thr Tyr Gly Ser Ser Thr 
                85                  90                  95      


Gly Pro Val Tyr Val Ser Asp Ser Val Thr Leu Val Asn Val Ala Thr 
            100                 105                 110         


Gly Ala Gln Ala Val Ala Arg Ser Leu Asp Trp Thr Lys Val Thr Leu 
        115                 120                 125             


Asp Gly Arg Pro Leu Ser Thr Thr Gln Gln Tyr Ser Lys Thr Phe Phe 
    130                 135                 140                 


Val Leu Pro Leu Arg Gly Lys Leu Ser Phe Trp Glu Ala Gly Thr Thr 
145                 150                 155                 160 


Lys Ala Gly Tyr Pro Tyr Asn Tyr Asn Thr Thr Ala Ser Asp Gln Leu 
                165                 170                 175     


Leu Val Glu Asn Ala Ala Gly His Arg Val Ala Ile Ser Thr Tyr Thr 
            180                 185                 190         


Thr Ser Leu Gly Ala Gly Pro Val Ser Ile Ser Ala Val Ala Val Leu 
        195                 200                 205             


Ala Pro His Ser Ala Leu Ala Leu Leu Glu Asp Thr Met Asp Tyr Pro 
    210                 215                 220                 


Ala Arg Ala His Thr Phe Asp Asp Phe Ser Pro Glu Ser Arg Pro Leu 
225                 230                 235                 240 


Gly Leu Gln Gly Ser Ala Phe Gln Ser Thr Val Ala Glu Leu Gln Arg 
                245                 250                 255     


Leu Lys Met Lys Val Gly Lys Thr Arg Glu Leu 
            260                 265         


<210>  28
<211>  267
<212>  PRT
<213>  artificial sequence

<220>
<223>  Hepatitis E virus

<400>  28

Gln Leu Phe Tyr Ser Arg Pro Val Val Ser Ala Asn Gly Glu Pro Thr 
1               5                   10                  15      


Val Lys Leu Tyr Thr Ser Val Glu Asn Ala Gln Gln Asp Lys Gly Ile 
            20                  25                  30          


Ala Ile Pro His Asp Ile Asp Leu Gly Glu Ser Arg Val Val Ile Gln 
        35                  40                  45              


Asp Tyr Asp Asn Gln His Glu Gln Asp Arg Pro Thr Pro Ser Pro Ala 
    50                  55                  60                  


Pro Ser Arg Pro Phe Ser Val Leu Arg Ala Asn Asp Val Leu Trp Leu 
65                  70                  75                  80  


Ser Leu Thr Ala Ala Glu Tyr Asp Gln Thr Thr Tyr Gly Ser Ser Thr 
                85                  90                  95      


Asn Pro Met Tyr Val Ser Asp Thr Val Thr Phe Val Asn Val Ala Thr 
            100                 105                 110         


Gly Ala Gln Gly Val Ser Arg Ser Leu Asp Trp Ser Lys Val Thr Leu 
        115                 120                 125             


Asp Gly Arg Pro Leu Met Thr Ile Gln Gln Tyr Ser Lys Thr Phe Phe 
    130                 135                 140                 


Val Leu Pro Leu Arg Gly Lys Leu Ser Phe Trp Glu Ala Gly Thr Thr 
145                 150                 155                 160 


Lys Ala Gly Tyr Pro Tyr Asn Tyr Asn Thr Thr Ala Ser Asp Gln Ile 
                165                 170                 175     


Leu Ile Glu Asn Ala Ala Gly His Arg Val Cys Ile Ser Thr Tyr Thr 
            180                 185                 190         


Thr Asn Leu Gly Ser Gly Pro Val Ser Ile Ser Ala Val Gly Val Leu 
        195                 200                 205             


Ala Pro His Ser Ala Leu Ala Ala Leu Glu Asp Thr Val Asp Tyr Pro 
    210                 215                 220                 


Ala Arg Ala His Thr Phe Asp Asp Phe Cys Pro Glu Cys Arg Ala Leu 
225                 230                 235                 240 


Gly Leu Gln Gly Cys Ala Phe Gln Ser Thr Val Ala Glu Leu Gln Arg 
                245                 250                 255     


Leu Lys Met Lys Val Gly Lys Thr Arg Glu Tyr 
            260                 265         


<210>  29
<211>  267
<212>  PRT
<213>  artificial sequence

<220>
<223>  Hepatitis E virus

<400>  29

Gln Leu Phe Tyr Ser Arg Pro Val Val Ser Ala Asn Gly Glu Pro Thr 
1               5                   10                  15      


Val Lys Leu Tyr Thr Ser Val Glu Asn Ala Gln Gln Asp Lys Gly Ile 
            20                  25                  30          


Ala Ile Pro His Asp Ile Asp Leu Gly Glu Ser Arg Val Val Ile Gln 
        35                  40                  45              


Asp Tyr Asp Asn Gln His Glu Gln Asp Arg Pro Thr Pro Ser Pro Ala 
    50                  55                  60                  


Pro Ser Arg Pro Phe Ser Val Leu Arg Ala Asn Asp Val Leu Trp Leu 
65                  70                  75                  80  


Ser Leu Thr Ala Ala Glu Tyr Asp Gln Thr Thr Tyr Gly Ser Ser Thr 
                85                  90                  95      


Asn Pro Met Tyr Val Ser Asp Thr Val Thr Phe Val Asn Val Ala Thr 
            100                 105                 110         


Gly Ala Gln Gly Val Ser Arg Ser Leu Asp Trp Ser Lys Val Thr Leu 
        115                 120                 125             


Asp Gly Arg Pro Leu Thr Thr Ile Gln Gln Tyr Ser Lys Thr Phe Phe 
    130                 135                 140                 


Val Leu Pro Leu Arg Gly Lys Leu Ser Phe Trp Glu Ala Gly Thr Thr 
145                 150                 155                 160 


Lys Ala Gly Tyr Pro Tyr Asn Tyr Asn Thr Thr Ala Ser Asp Gln Ile 
                165                 170                 175     


Leu Ile Glu Asn Ala Ala Gly His Arg Val Cys Ile Ser Thr Tyr Thr 
            180                 185                 190         


Thr Asn Leu Gly Ser Gly Pro Val Ser Ile Ser Ser Val Gly Val Leu 
        195                 200                 205             


Ala Pro His Ser Ala Leu Ala Ala Leu Glu Asp Thr Val Asp Tyr Pro 
    210                 215                 220                 


Ala Arg Ala His Thr Phe Asp Asp Phe Cys Pro Glu Cys Arg Thr Leu 
225                 230                 235                 240 


Gly Leu Gln Gly Cys Ala Phe Gln Ser Thr Val Ala Glu Leu Gln Arg 
                245                 250                 255     


Leu Lys Met Lys Val Gly Lys Thr Arg Glu Tyr 
            260                 265         


<210>  30
<211>  267
<212>  PRT
<213>  artificial sequence

<220>
<223>  Hepatitis E virus

<400>  30

Gln Leu Phe Tyr Ser Arg Pro Val Val Ser Ala Asn Gly Glu Pro Thr 
1               5                   10                  15      


Val Lys Leu Tyr Thr Ser Val Glu Asn Ala Gln Gln Asp Lys Gly Ile 
            20                  25                  30          


Ala Ile Pro His Asp Ile Asp Leu Gly Glu Ser Arg Val Val Ile Gln 
        35                  40                  45              


Asp Tyr Asp Asn Gln His Glu Gln Asp Arg Pro Thr Pro Ser Pro Ala 
    50                  55                  60                  


Pro Ser Arg Pro Phe Ser Val Leu Arg Ala Asn Asp Val Leu Trp Leu 
65                  70                  75                  80  


Ser Leu Thr Ala Ala Glu Tyr Asp Gln Thr Thr Tyr Gly Ser Ser Thr 
                85                  90                  95      


Asn Pro Met Tyr Val Ser Asp Thr Val Thr Phe Val Asn Val Ala Thr 
            100                 105                 110         


Gly Ala Gln Gly Val Ser Arg Ser Leu Asp Trp Ser Lys Val Thr Leu 
        115                 120                 125             


Asp Gly Arg Pro Leu Thr Thr Ile Gln Gln Tyr Ser Lys Thr Phe Phe 
    130                 135                 140                 


Val Leu Pro Leu Arg Gly Lys Leu Ser Phe Trp Glu Ala Gly Thr Thr 
145                 150                 155                 160 


Lys Ala Gly Tyr Pro Tyr Asn Tyr Asn Thr Thr Ala Ser Asp Gln Ile 
                165                 170                 175     


Leu Ile Glu Asn Ala Ala Gly His Arg Val Cys Ile Ser Thr Tyr Thr 
            180                 185                 190         


Thr Asn Leu Gly Ser Gly Pro Val Ser Ile Ser Ser Val Gly Val Leu 
        195                 200                 205             


Ala Pro His Ser Ala Leu Ala Ala Leu Glu Asp Thr Val Asp Tyr Pro 
    210                 215                 220                 


Ala Arg Ala His Thr Phe Asp Asp Phe Cys Pro Glu Cys Arg Thr Leu 
225                 230                 235                 240 


Gly Leu Gln Gly Cys Ala Phe Gln Ser Thr Val Ala Glu Leu Gln Arg 
                245                 250                 255     


Leu Lys Met Lys Val Gly Lys Thr Arg Glu Tyr 
            260                 265         


<210>  31
<211>  267
<212>  PRT
<213>  artificial sequence

<220>
<223>  Hepatitis E virus

<400>  31

Gln Leu Phe Tyr Ser Arg Pro Val Val Ser Ala Asn Gly Glu Pro Thr 
1               5                   10                  15      


Val Lys Leu Tyr Thr Ser Val Glu Asn Ala Gln Gln Asp Lys Gly Ile 
            20                  25                  30          


Ala Ile Pro His Asp Ile Asp Leu Gly Glu Ser Arg Val Val Ile Gln 
        35                  40                  45              


Asp Tyr Asp Asn Gln His Glu Gln Asp Arg Pro Thr Pro Ser Pro Ala 
    50                  55                  60                  


Pro Ser Arg Pro Phe Ser Val Leu Arg Ala Asn Asp Val Leu Trp Leu 
65                  70                  75                  80  


Ser Leu Thr Ala Ala Glu Tyr Asp Gln Thr Thr Tyr Gly Ser Ser Thr 
                85                  90                  95      


Asn Pro Met Tyr Val Ser Asp Thr Val Thr Phe Val Asn Val Ala Thr 
            100                 105                 110         


Gly Ala Gln Gly Val Ser Arg Ser Leu Asp Trp Ser Lys Val Thr Leu 
        115                 120                 125             


Asp Gly Arg Pro Leu Met Thr Ile Gln Gln Tyr Ser Lys Thr Phe Phe 
    130                 135                 140                 


Val Leu Pro Leu Arg Gly Lys Leu Ser Phe Trp Glu Ala Gly Thr Thr 
145                 150                 155                 160 


Lys Ala Gly Tyr Pro Tyr Asn Tyr Asn Thr Thr Ala Ser Asp Gln Ile 
                165                 170                 175     


Leu Ile Glu Asn Ala Ala Gly His Arg Val Cys Ile Ser Thr Tyr Thr 
            180                 185                 190         


Thr Asn Leu Gly Ser Gly Pro Val Ser Ile Ser Ala Val Gly Val Leu 
        195                 200                 205             


Ala Pro His Ser Ala Leu Ala Ala Leu Glu Asp Thr Val Asp Tyr Pro 
    210                 215                 220                 


Ala Arg Ala His Thr Phe Asp Asp Phe Cys Pro Glu Cys Arg Thr Leu 
225                 230                 235                 240 


Gly Leu Gln Gly Cys Ala Phe Gln Ser Thr Val Ala Glu Leu Gln Arg 
                245                 250                 255     


Leu Lys Met Lys Val Gly Lys Thr Arg Glu Tyr 
            260                 265         


<210>  32
<211>  267
<212>  PRT
<213>  artificial sequence

<220>
<223>  Hepatitis E virus

<400>  32

Gln Leu Phe Tyr Ser Arg Pro Val Val Ser Ala Asn Gly Glu Pro Thr 
1               5                   10                  15      


Val Lys Leu Tyr Thr Ser Val Glu Asn Ala Gln Gln Asp Lys Gly Ile 
            20                  25                  30          


Ala Ile Pro His Asp Ile Asp Leu Gly Glu Ser Arg Val Val Ile Gln 
        35                  40                  45              


Asp Tyr Asp Asn Gln His Glu Gln Asp Arg Pro Thr Pro Ser Pro Ala 
    50                  55                  60                  


Pro Ser Arg Pro Phe Ser Val Leu Arg Ala Asn Asp Val Leu Trp Leu 
65                  70                  75                  80  


Ser Leu Thr Ala Ala Glu Tyr Asp Gln Thr Thr Tyr Gly Ser Ser Thr 
                85                  90                  95      


Asn Pro Met Tyr Val Ser Asp Thr Val Thr Phe Val Asn Val Ala Thr 
            100                 105                 110         


Gly Ala Gln Gly Val Ser Arg Ser Leu Asp Trp Ser Lys Val Thr Leu 
        115                 120                 125             


Asp Gly Arg Pro Leu Met Thr Ile Gln Gln Tyr Ser Lys Thr Phe Phe 
    130                 135                 140                 


Val Leu Pro Leu Arg Gly Lys Leu Ser Phe Trp Glu Ala Gly Thr Thr 
145                 150                 155                 160 


Lys Ala Gly Tyr Pro Tyr Asn Tyr Asn Thr Thr Ala Ser Asp Gln Ile 
                165                 170                 175     


Leu Ile Glu Asn Ala Ala Gly His Arg Val Cys Ile Ser Thr Tyr Thr 
            180                 185                 190         


Thr Asn Leu Gly Ser Gly Pro Val Ser Ile Ser Ala Val Gly Val Leu 
        195                 200                 205             


Ala Pro His Ser Ala Leu Ala Ala Leu Glu Asp Thr Val Asp Tyr Pro 
    210                 215                 220                 


Ala Arg Ala His Thr Phe Asp Asp Phe Cys Pro Glu Cys Arg Ala Leu 
225                 230                 235                 240 


Gly Leu Gln Gly Cys Ala Phe Gln Ser Thr Val Ala Glu Leu Gln Arg 
                245                 250                 255     


Leu Lys Met Lys Val Gly Lys Thr Arg Glu Tyr 
            260                 265         


<210>  33
<211>  267
<212>  PRT
<213>  artificial sequence

<220>
<223>  Hepatitis E virus

<400>  33

Gln Leu Phe Tyr Ser Arg Pro Val Val Ser Ala Asn Gly Glu Pro Thr 
1               5                   10                  15      


Val Lys Leu Tyr Thr Ser Val Glu Asn Ala Gln Gln Asp Lys Gly Ile 
            20                  25                  30          


Ala Ile Pro His Asp Ile Asp Leu Gly Glu Ser Arg Val Val Ile Gln 
        35                  40                  45              


Asp Tyr Asp Asn Gln His Glu Gln Asp Arg Pro Thr Pro Ser Pro Ala 
    50                  55                  60                  


Pro Ser Arg Pro Phe Ser Val Leu Arg Ala Asn Asp Val Leu Trp Leu 
65                  70                  75                  80  


Ser Leu Thr Ala Ala Glu Tyr Asp Gln Thr Thr Tyr Gly Ser Ser Thr 
                85                  90                  95      


Asn Pro Met Tyr Val Ser Asp Thr Val Thr Phe Val Asn Val Ala Thr 
            100                 105                 110         


Gly Ala Gln Gly Val Ser Arg Ser Leu Asp Trp Ser Lys Val Thr Leu 
        115                 120                 125             


Asp Gly Arg Pro Leu Thr Thr Ile Gln Gln Tyr Ser Lys Thr Phe Tyr 
    130                 135                 140                 


Val Leu Pro Leu Arg Gly Lys Leu Ser Phe Trp Glu Ala Gly Thr Thr 
145                 150                 155                 160 


Lys Ala Gly Tyr Pro Tyr Asn Tyr Asn Thr Thr Ala Ser Asp Gln Ile 
                165                 170                 175     


Leu Ile Glu Asn Ala Ala Gly His Arg Val Cys Ile Ser Thr Tyr Thr 
            180                 185                 190         


Thr Asn Leu Gly Ser Gly Pro Val Ser Ile Ser Ala Val Gly Val Leu 
        195                 200                 205             


Ala Pro His Ser Ala Leu Ala Val Leu Glu Asp Thr Val Asp Tyr Pro 
    210                 215                 220                 


Ala Arg Ala His Thr Phe Asp Asp Phe Cys Pro Glu Cys Arg Ala Leu 
225                 230                 235                 240 


Gly Leu Gln Gly Cys Ala Phe Gln Ser Thr Val Ala Glu Leu Gln Arg 
                245                 250                 255     


Leu Lys Met Lys Val Gly Lys Thr Arg Glu Tyr 
            260                 265         


<210>  34
<211>  267
<212>  PRT
<213>  artificial sequence

<220>
<223>  Hepatitis E virus

<400>  34

Gln Leu Phe Tyr Ser Arg Pro Val Val Ser Ala Asn Gly Glu Pro Thr 
1               5                   10                  15      


Val Lys Leu Tyr Thr Ser Val Glu Asn Ala Gln Gln Asp Lys Gly Ile 
            20                  25                  30          


Ala Ile Pro His Asp Ile Asp Leu Gly Glu Ser Arg Val Val Ile Gln 
        35                  40                  45              


Asp Tyr Asp Asn Gln His Glu Gln Asp Arg Pro Thr Pro Ser Pro Ala 
    50                  55                  60                  


Pro Ser Arg Pro Phe Ser Val Leu Arg Ala Asn Asp Val Leu Trp Leu 
65                  70                  75                  80  


Ser Leu Thr Ala Ala Glu Tyr Asp Gln Thr Thr Tyr Gly Ser Ser Thr 
                85                  90                  95      


Asn Pro Met Tyr Val Ser Asp Thr Val Thr Phe Val Asn Val Ala Thr 
            100                 105                 110         


Gly Ala Gln Gly Val Ser Arg Ser Leu Asp Trp Ser Lys Val Thr Leu 
        115                 120                 125             


Asp Gly Arg Pro Leu Thr Thr Ile Gln Gln Tyr Ser Lys Thr Phe Tyr 
    130                 135                 140                 


Val Leu Pro Leu Arg Gly Lys Leu Ser Phe Trp Glu Ala Gly Thr Thr 
145                 150                 155                 160 


Lys Ala Gly Tyr Pro Tyr Asn Tyr Asn Thr Thr Ala Ser Asp Gln Ile 
                165                 170                 175     


Leu Ile Glu Asn Ala Ala Gly His Arg Val Cys Ile Ser Thr Tyr Thr 
            180                 185                 190         


Thr Asn Leu Gly Ser Gly Pro Val Ser Ile Ser Ala Val Gly Val Leu 
        195                 200                 205             


Ala Pro His Ser Ala Leu Ala Ile Leu Glu Asp Thr Ala Asp Tyr Pro 
    210                 215                 220                 


Ala Arg Ala His Thr Phe Asp Asp Phe Cys Pro Glu Cys Arg Ser Leu 
225                 230                 235                 240 


Gly Leu Gln Gly Cys Ala Phe Gln Ser Thr Val Ala Glu Leu Gln Arg 
                245                 250                 255     


Leu Lys Met Lys Val Gly Lys Thr Arg Glu Tyr 
            260                 265         


<210>  35
<211>  267
<212>  PRT
<213>  artificial sequence

<220>
<223>  Hepatitis E virus

<400>  35

Gln Leu Phe Tyr Ser Arg Pro Val Val Ser Ala Asn Gly Glu Leu Thr 
1               5                   10                  15      


Val Lys Leu Tyr Thr Ser Val Glu Asn Ala Gln Gln Asp Lys Gly Val 
            20                  25                  30          


Ala Ile Pro His Asp Ile Asp Leu Gly Glu Ser Arg Val Val Ile Gln 
        35                  40                  45              


Asp Tyr Asp Asn Gln His Glu Gln Asp Arg Pro Thr Pro Ser Pro Ala 
    50                  55                  60                  


Pro Ser Arg Pro Phe Ser Val Leu Arg Ala Asn Asp Val Leu Trp Leu 
65                  70                  75                  80  


Ser Leu Thr Ala Ala Glu Tyr Asp Gln Thr Thr Tyr Gly Ser Ser Thr 
                85                  90                  95      


Asn Pro Met Tyr Val Ser Asp Thr Val Thr Phe Val Asn Val Ala Thr 
            100                 105                 110         


Gly Ala Gln Gly Val Ser Arg Ser Leu Asp Trp Ser Lys Val Thr Leu 
        115                 120                 125             


Asp Gly Arg Pro Leu Thr Thr Ile Gln Gln Tyr Ser Lys Thr Phe Tyr 
    130                 135                 140                 


Val Leu Pro Leu Arg Gly Lys Leu Ser Phe Trp Glu Ala Gly Thr Thr 
145                 150                 155                 160 


Lys Ala Gly Tyr Pro Tyr Asn Tyr Asn Thr Thr Ala Ser Asp Gln Ile 
                165                 170                 175     


Leu Ile Glu Asn Ala Ala Gly His Arg Val Cys Ile Ser Thr Tyr Thr 
            180                 185                 190         


Thr Asn Leu Gly Ser Gly Pro Val Ser Val Ser Ala Val Gly Val Leu 
        195                 200                 205             


Ala Pro His Ser Ala Leu Ala Ala Leu Glu Asp Thr Ala Asp Tyr Pro 
    210                 215                 220                 


Ala Arg Ala His Thr Phe Asp Asp Phe Cys Pro Glu Cys Arg Ala Leu 
225                 230                 235                 240 


Gly Leu Gln Gly Cys Ala Phe Gln Ser Thr Val Gly Glu Leu Gln Arg 
                245                 250                 255     


Leu Lys Met Lys Val Gly Lys Thr Arg Glu Tyr 
            260                 265         


<210>  36
<211>  267
<212>  PRT
<213>  artificial sequence

<220>
<223>  Hepatitis E virus

<400>  36

Gln Leu Phe Tyr Ser Arg Pro Val Val Ser Ala Asn Gly Glu Pro Thr 
1               5                   10                  15      


Val Lys Leu Tyr Thr Ser Val Glu Asn Ala Gln Gln Asp Lys Gly Ile 
            20                  25                  30          


Ala Ile Pro His Asp Ile Asp Leu Gly Glu Ser Arg Val Val Ile Gln 
        35                  40                  45              


Asp Tyr Asp Asn Gln His Glu Gln Asp Arg Pro Thr Pro Ser Pro Ala 
    50                  55                  60                  


Pro Ser Arg Pro Phe Ser Val Leu Arg Ala Asn Asp Val Leu Trp Leu 
65                  70                  75                  80  


Ser Leu Thr Ala Ala Glu Tyr Asp Gln Thr Thr Tyr Gly Ser Ser Thr 
                85                  90                  95      


Asn Pro Met Tyr Val Ser Asp Thr Val Thr Phe Val Asn Val Ala Thr 
            100                 105                 110         


Gly Ala Gln Gly Val Ser Arg Ser Leu Asp Trp Ser Lys Val Thr Leu 
        115                 120                 125             


Asp Gly Arg Pro Leu Thr Thr Ile Gln Gln Tyr Ser Lys Thr Phe Phe 
    130                 135                 140                 


Val Leu Pro Leu Arg Gly Lys Leu Ser Phe Trp Glu Ala Gly Thr Thr 
145                 150                 155                 160 


Lys Ala Gly Tyr Pro Tyr Asn Tyr Asn Thr Thr Ala Ser Asp Gln Ile 
                165                 170                 175     


Leu Ile Glu Asn Ala Ala Gly His Arg Val Cys Ile Ser Thr Tyr Thr 
            180                 185                 190         


Thr Asn Leu Gly Ser Gly Pro Val Ser Ile Ser Ala Val Gly Val Leu 
        195                 200                 205             


Ala Pro His Ser Ala Leu Ala Ala Leu Glu Asp Thr Val Asp Tyr Pro 
    210                 215                 220                 


Ala Arg Ala His Thr Phe Asp Asp Phe Cys Pro Glu Cys Arg Thr Leu 
225                 230                 235                 240 


Gly Leu Gln Gly Cys Ala Phe Gln Ser Thr Val Ala Glu Leu Gln Arg 
                245                 250                 255     


Leu Lys Met Lys Val Gly Lys Thr Arg Glu Tyr 
            260                 265         


<210>  37
<211>  264
<212>  PRT
<213>  artificial sequence

<220>
<223>  Hepatitis E virus

<400>  37

Gln Leu Phe Tyr Ser Arg Pro Val Val Ser Ala Asn Gly Glu Pro Thr 
1               5                   10                  15      


Val Lys Leu Tyr Thr Ser Val Glu Asn Ala Gln Gln Asp Lys Gly Ile 
            20                  25                  30          


Ala Ile Pro His Asp Ile Asp Leu Gly Glu Ser Arg Val Gly Ile Gln 
        35                  40                  45              


Asp Tyr Asp Asn Gln His Glu Gln Asp Arg Pro Thr Pro Ser Pro Ala 
    50                  55                  60                  


Pro Ser Arg Pro Phe Ser Val Leu Arg Ala Asn Asp Val Leu Trp Leu 
65                  70                  75                  80  


Ser Leu Thr Ala Ala Glu Tyr Asp Gln Thr Thr Tyr Gly Ser Ser Thr 
                85                  90                  95      


Asn Pro Met Tyr Val Ser Asp Thr Val Thr Phe Val Asn Val Ala Thr 
            100                 105                 110         


Gly Ala Gln Gly Val Ser Arg Ser Leu Asp Trp Ser Lys Val Thr Leu 
        115                 120                 125             


Asp Gly Arg Ser Leu Thr Thr Ile Gln Gln Tyr Ser Lys Thr Phe Phe 
    130                 135                 140                 


Val Leu Pro Leu Arg Gly Lys Leu Ser Phe Trp Glu Ala Gly Thr Thr 
145                 150                 155                 160 


Lys Ala Gly Tyr Pro Tyr Asn Tyr Asn Thr Thr Ala Ser Asp Gln Ile 
                165                 170                 175     


Leu Ile Glu Asn Ala Ala Gly His Arg Val Cys Ile Ser Thr Tyr Thr 
            180                 185                 190         


Thr Asn Leu Gly Ser Gly Pro Val Ser Ile Ser Ala Val Gly Val Leu 
        195                 200                 205             


Ala Pro His Ser Ala Leu Ala Val Leu Glu Asp Thr Val Asp Tyr Pro 
    210                 215                 220                 


Ala Arg Ala His Thr Phe Asp Asp Phe Cys Pro Glu Cys Arg Ala Leu 
225                 230                 235                 240 


Gly Leu Gln Gly Cys Ala Phe Gln Ser Thr Val Ala Glu Leu Gln Arg 
                245                 250                 255     


Leu Lys Met Lys Val Gly Asn His 
            260                 


<210>  38
<211>  267
<212>  PRT
<213>  artificial sequence

<220>
<223>  Hepatitis E virus

<400>  38

Gln Leu Phe Tyr Ser Arg Pro Val Val Ser Ala Asn Gly Glu Pro Thr 
1               5                   10                  15      


Val Lys Leu Tyr Thr Ser Val Glu Asn Ala Gln Gln Asp Lys Gly Ile 
            20                  25                  30          


Ala Ile Pro His Asp Ile Asp Leu Gly Glu Ser Arg Val Val Ile Gln 
        35                  40                  45              


Asp Tyr Asp Asn Gln His Glu Gln Asp Arg Pro Thr Pro Ser Pro Ala 
    50                  55                  60                  


Pro Ser Arg Pro Phe Ser Val Leu Arg Ala Asn Asp Val Leu Trp Leu 
65                  70                  75                  80  


Ser Leu Thr Ala Ala Glu Tyr Asp Gln Ser Thr Tyr Gly Ser Ser Thr 
                85                  90                  95      


Gly Pro Val Tyr Val Ser Asp Ser Val Thr Leu Val Asn Val Ala Thr 
            100                 105                 110         


Gly Ala Gln Ala Val Ala Arg Ser Leu Asp Trp Thr Lys Val Thr Leu 
        115                 120                 125             


Asp Gly Arg Pro Leu Ser Thr Ile Gln Gln Tyr Ser Lys Thr Phe Phe 
    130                 135                 140                 


Val Leu Pro Leu Arg Gly Lys Leu Ser Phe Trp Glu Ala Gly Thr Thr 
145                 150                 155                 160 


Lys Ala Gly Tyr Pro Tyr Asn Tyr Asn Thr Thr Ala Ser Asp Gln Leu 
                165                 170                 175     


Leu Val Glu Asn Ala Ala Gly His Arg Val Ala Ile Ser Thr Tyr Thr 
            180                 185                 190         


Thr Ser Leu Gly Ala Gly Pro Val Ser Ile Ser Ala Val Ala Val Leu 
        195                 200                 205             


Ala Pro His Ser Ala Leu Ala Leu Leu Glu Asp Thr Leu Asp Tyr Pro 
    210                 215                 220                 


Ala Arg Ala His Thr Phe Asp Asp Phe Cys Pro Glu Cys Arg Pro Leu 
225                 230                 235                 240 


Gly Leu Gln Gly Cys Ala Phe Gln Ser Thr Val Ala Glu Leu Gln Arg 
                245                 250                 255     


Leu Lys Met Lys Val Gly Lys Thr Arg Glu Leu 
            260                 265         


<210>  39
<211>  267
<212>  PRT
<213>  artificial sequence

<220>
<223>  Hepatitis E virus

<400>  39

Gln Leu Phe Tyr Ser Arg Pro Val Val Ser Ala Asn Gly Glu Pro Thr 
1               5                   10                  15      


Val Lys Leu Tyr Thr Ser Val Glu Asn Ala Gln Gln Asp Lys Gly Ile 
            20                  25                  30          


Thr Ile Pro His Asp Ile Asp Leu Gly Asp Ser Arg Val Val Ile Gln 
        35                  40                  45              


Asp Tyr Asp Asn Gln His Glu Gln Asp Arg Pro Thr Pro Ser Pro Ala 
    50                  55                  60                  


Pro Ser Arg Pro Phe Ser Val Leu Arg Ala Asn Asp Val Leu Trp Leu 
65                  70                  75                  80  


Ser Leu Thr Ala Ala Glu Tyr Asp Gln Thr Thr Tyr Gly Ser Ser Thr 
                85                  90                  95      


Asn Pro Met Tyr Val Ser Asp Thr Val Thr Leu Val Asn Val Ala Thr 
            100                 105                 110         


Gly Ala Gln Ala Val Ala Arg Ser Leu Asp Trp Ser Lys Val Thr Leu 
        115                 120                 125             


Asp Gly Arg Pro Leu Thr Thr Ile Gln Gln Tyr Ser Lys Thr Phe Tyr 
    130                 135                 140                 


Val Leu Pro Leu Arg Gly Lys Leu Ser Phe Trp Glu Ala Gly Thr Thr 
145                 150                 155                 160 


Lys Ala Gly Tyr Pro Tyr Asn Tyr Asn Thr Thr Ala Ser Asp Gln Ile 
                165                 170                 175     


Leu Ile Glu Asn Ala Ala Gly His Arg Val Ala Ile Ser Thr Tyr Thr 
            180                 185                 190         


Thr Ser Leu Gly Ala Gly Pro Thr Ser Ile Ser Ala Val Gly Val Leu 
        195                 200                 205             


Ala Pro His Ser Ala Leu Ala Val Leu Glu Asp Thr Val Asp Tyr Pro 
    210                 215                 220                 


Ala Arg Ala His Thr Phe Asp Asp Phe Cys Pro Glu Cys Arg Thr Leu 
225                 230                 235                 240 


Gly Leu Gln Gly Cys Ala Phe Gln Ser Thr Ile Ala Glu Leu Gln Arg 
                245                 250                 255     


Leu Lys Met Lys Val Gly Lys Thr Arg Glu Ser 
            260                 265         


<210>  40
<211>  267
<212>  PRT
<213>  artificial sequence

<220>
<223>  Hepatitis E virus

<400>  40

Gln Leu Phe Tyr Ser Arg Pro Val Val Ser Ala His Gly Glu Pro Thr 
1               5                   10                  15      


Val Lys Leu Tyr Thr Ser Val Glu Asn Ala Gln Gln Asp Lys Gly Ile 
            20                  25                  30          


Ala Ile Pro His Asp Ile Asp Leu Gly Glu Ser Arg Val Val Ile Gln 
        35                  40                  45              


Asp Tyr Asp Asn Gln His Glu Gln Asp Arg Pro Thr Pro Ser Pro Ala 
    50                  55                  60                  


Pro Ser Arg Pro Phe Ser Val Leu Arg Ala Asn Asp Val Leu Trp Leu 
65                  70                  75                  80  


Ser Leu Thr Ala Ala Glu Tyr Asp Gln Ser Thr Tyr Gly Ser Ser Thr 
                85                  90                  95      


Ala Pro Val Tyr Val Ser Asp Ser Val Thr Leu Val Asn Val Ala Thr 
            100                 105                 110         


Gly Ala Gln Ala Val Ala Arg Ser Leu Asp Trp Thr Lys Val Thr Leu 
        115                 120                 125             


Asp Gly Arg Pro Leu Ser Thr Ile Gln Gln Tyr Pro Lys Thr Phe Phe 
    130                 135                 140                 


Val Leu Pro Leu Arg Gly Lys Leu Ser Phe Trp Glu Ala Gly Thr Thr 
145                 150                 155                 160 


Lys Ala Gly Tyr Pro Tyr Asn Tyr Asn Thr Thr Ala Ser Asp Gln Leu 
                165                 170                 175     


Leu Val Glu Asn Ala Ala Gly His Arg Val Ala Ile Ser Thr Tyr Thr 
            180                 185                 190         


Thr Ser Leu Gly Ala Gly Pro Val Ser Ile Ser Ala Val Ala Val Leu 
        195                 200                 205             


Ala Pro His Ser Ala Leu Ala Leu Leu Glu Asp Thr Leu Asp Tyr Pro 
    210                 215                 220                 


Ala Cys Ala His Thr Phe Asp Asp Phe Cys Pro Glu Cys Arg Pro Leu 
225                 230                 235                 240 


Gly Leu Gln Gly Cys Ala Phe Gln Ser Thr Val Ala Glu Leu Gln Arg 
                245                 250                 255     


Leu Lys Met Lys Val Gly Lys Thr Arg Glu Leu 
            260                 265         


<210>  41
<211>  267
<212>  PRT
<213>  artificial sequence

<220>
<223>  Hepatitis E virus

<400>  41

Gln Leu Phe Tyr Ser Arg Pro Val Val Ser Ala Asn Gly Glu Pro Thr 
1               5                   10                  15      


Val Lys Leu Tyr Thr Ser Val Glu Asn Ala Gln Gln Asp Lys Gly Ile 
            20                  25                  30          


Ala Ile Pro Asn Asp Ile Asp Leu Gly Glu Ser Arg Val Val Ile Gln 
        35                  40                  45              


Asp Tyr Asp Asn Gln His Glu Gln Asp Arg Pro Thr Pro Ser Pro Ala 
    50                  55                  60                  


Pro Ser Arg Pro Phe Ser Val Leu Arg Ala Asn Asp Val Leu Trp Leu 
65                  70                  75                  80  


Ser Leu Thr Ala Ala Glu Tyr Asp Gln Ser Thr Tyr Gly Ser Ser Thr 
                85                  90                  95      


Gly Pro Val Tyr Val Ser Asp Ser Val Thr Leu Val Asn Val Ala Thr 
            100                 105                 110         


Gly Ala Gln Ala Val Ala Arg Ser Leu Asp Trp Thr Lys Val Thr Leu 
        115                 120                 125             


Asp Gly Arg Pro Leu Ser Thr Ile Gln Gln Tyr Ser Lys Ile Phe Phe 
    130                 135                 140                 


Val Leu Pro Leu Arg Gly Lys Leu Ser Phe Trp Glu Ala Gly Thr Thr 
145                 150                 155                 160 


Arg Pro Gly Tyr Pro Tyr Asn Tyr Asn Thr Thr Ala Ser Asp Gln Leu 
                165                 170                 175     


Leu Val Glu Asn Ala Ala Gly His Arg Val Ala Ile Ser Thr Tyr Thr 
            180                 185                 190         


Thr Ser Leu Gly Ala Gly Pro Val Ser Ile Ser Ala Val Ala Val Leu 
        195                 200                 205             


Gly Pro His Ser Ala Leu Ala Leu Leu Glu Asp Thr Leu Asp Tyr Pro 
    210                 215                 220                 


Ala Arg Ala His Thr Phe Asp Asp Phe Cys Pro Glu Cys Arg Pro Leu 
225                 230                 235                 240 


Gly Leu Gln Gly Cys Ala Phe Gln Ser Thr Val Ala Glu Leu Gln Arg 
                245                 250                 255     


Leu Lys Met Lys Val Gly Lys Thr Arg Glu Leu 
            260                 265         


<210>  42
<211>  267
<212>  PRT
<213>  artificial sequence

<220>
<223>  Hepatitis E virus

<400>  42

Gln Leu Phe Tyr Ser Arg Pro Val Val Ser Ala Asn Gly Glu Pro Thr 
1               5                   10                  15      


Val Lys Leu Tyr Thr Ser Val Glu Asn Ala Gln Gln Asp Lys Gly Ile 
            20                  25                  30          


Thr Ile Pro His Asp Ile Asp Leu Gly Asp Ser Arg Val Val Ile Gln 
        35                  40                  45              


Asp Tyr Asp Asn Gln His Glu Gln Asp Arg Pro Thr Pro Ser Pro Ala 
    50                  55                  60                  


Pro Ser Arg Pro Phe Ser Val Leu Arg Ala Asn Asp Val Leu Trp Leu 
65                  70                  75                  80  


Ser Leu Thr Ala Ala Glu Tyr Asp Gln Thr Thr Tyr Gly Ser Ser Thr 
                85                  90                  95      


Asn Pro Met Tyr Val Ser Asp Thr Val Thr Leu Val Asn Val Ala Thr 
            100                 105                 110         


Gly Ala Gln Ala Val Ala Arg Ser Leu Asp Trp Ser Lys Val Thr Leu 
        115                 120                 125             


Asp Gly Arg Pro Leu Thr Thr Ile Gln Gln Tyr Ser Lys Thr Phe Tyr 
    130                 135                 140                 


Val Leu Pro Leu Arg Gly Lys Leu Ser Phe Trp Glu Ala Gly Thr Thr 
145                 150                 155                 160 


Lys Ala Gly Tyr Pro Tyr Asn Tyr Asn Thr Thr Ala Ser Asp Gln Ile 
                165                 170                 175     


Leu Ile Glu Asn Ala Ala Gly His Arg Val Ala Ile Ser Thr Tyr Thr 
            180                 185                 190         


Thr Ser Leu Gly Ala Gly Pro Thr Ser Ile Ser Ala Val Gly Val Leu 
        195                 200                 205             


Ala Pro His Ser Ala Leu Ala Val Leu Glu Asp Thr Ile Asp Tyr Pro 
    210                 215                 220                 


Ala Arg Ala His Thr Phe Asp Asp Phe Cys Pro Glu Cys Arg Thr Leu 
225                 230                 235                 240 


Gly Leu Gln Gly Cys Ala Phe Gln Ser Thr Ile Ala Glu Leu Gln Arg 
                245                 250                 255     


Leu Lys Met Lys Val Gly Lys Thr Arg Glu Ser 
            260                 265         


<210>  43
<211>  267
<212>  PRT
<213>  artificial sequence

<220>
<223>  Hepatitis E virus

<400>  43

Gln Leu Phe Tyr Ser Arg Pro Val Val Ser Ala Asn Gly Glu Pro Thr 
1               5                   10                  15      


Val Lys Leu Tyr Thr Ser Val Glu Asn Ala Gln Gln Asp Lys Gly Ile 
            20                  25                  30          


Ala Ile Pro His Asp Ile Asp Leu Gly Glu Ser Arg Val Val Ile Gln 
        35                  40                  45              


Asp Tyr Asp Asn Gln His Glu Gln Asp Arg Pro Thr Pro Ser Pro Ala 
    50                  55                  60                  


Pro Ser Arg Pro Phe Ser Val Leu Arg Ala Asn Asp Val Leu Trp Leu 
65                  70                  75                  80  


Ser Leu Thr Ala Ala Glu Tyr Asp Gln Ser Thr Tyr Gly Ser Ser Thr 
                85                  90                  95      


Gly Pro Val Tyr Val Ser Asp Ser Val Thr Leu Val Asn Val Ala Thr 
            100                 105                 110         


Gly Ala Gln Ala Val Ala Arg Ser Leu Asp Trp Thr Lys Val Thr Leu 
        115                 120                 125             


Asp Gly Arg Pro Leu Ser Thr Ile Gln Gln Tyr Ser Lys Thr Phe Phe 
    130                 135                 140                 


Val Leu Pro Leu Arg Gly Lys Leu Ser Phe Trp Glu Ala Gly Thr Thr 
145                 150                 155                 160 


Lys Ala Gly Tyr Pro Tyr Asn Tyr Asn Thr Thr Ala Ser Asp Gln Leu 
                165                 170                 175     


Leu Val Glu Asn Ala Ala Gly His Arg Val Ala Ile Ser Thr Tyr Thr 
            180                 185                 190         


Thr Ser Leu Gly Ala Gly Pro Val Ser Ile Ser Ala Val Ala Val Leu 
        195                 200                 205             


Ala Pro His Ser Val Leu Ala Leu Leu Glu Asp Thr Met Asp Tyr Pro 
    210                 215                 220                 


Ala Arg Ala His Thr Phe Asp Asp Phe Cys Pro Glu Cys Arg Pro Leu 
225                 230                 235                 240 


Gly Leu Gln Gly Cys Ala Phe Gln Ser Thr Val Ala Glu Leu Gln Arg 
                245                 250                 255     


Leu Lys Met Lys Val Gly Lys Thr Arg Glu Leu 
            260                 265         


<210>  44
<211>  267
<212>  PRT
<213>  artificial sequence

<220>
<223>  Hepatitis E virus


<220>
<221>  misc_feature
<222>  (88)..(88)
<223>  Xaa can be any naturally occurring amino acid

<400>  44

Gln Leu Phe Tyr Ser Arg Pro Val Val Ser Ala Asn Gly Glu Pro Thr 
1               5                   10                  15      


Val Lys Leu Tyr Thr Ser Val Glu Asn Ala Gln Gln Asp Lys Gly Ile 
            20                  25                  30          


Thr Ile Pro His Asp Ile Asp Leu Gly Asp Ser Arg Val Val Ile Gln 
        35                  40                  45              


Asp Tyr Asp Asn Gln His Glu Gln Asp Arg Pro Thr Pro Ser Pro Ala 
    50                  55                  60                  


Pro Ser Arg Pro Phe Ser Val Leu Arg Ala Asn Asp Val Leu Trp Leu 
65                  70                  75                  80  


Ser Leu Thr Ala Ala Glu Tyr Xaa Gln Thr Thr Tyr Gly Ser Ser Thr 
                85                  90                  95      


Asn Pro Met Tyr Val Ser Asp Thr Val Thr Leu Val Asn Val Ala Thr 
            100                 105                 110         


Gly Ala Gln Ala Val Ala Arg Ser Leu Asp Trp Ser Lys Val Thr Leu 
        115                 120                 125             


Asp Gly Arg Pro Leu Thr Thr Ile Gln Gln Tyr Ser Lys Lys Phe Tyr 
    130                 135                 140                 


Val Leu Pro Leu Arg Gly Lys Leu Ser Phe Trp Glu Ala Gly Thr Thr 
145                 150                 155                 160 


Lys Ala Gly Tyr Pro Tyr Asn Tyr Asn Thr Thr Ala Ser Asp Gln Ile 
                165                 170                 175     


Leu Ile Glu Asn Ala Ala Gly His Arg Val Ala Ile Ser Thr Tyr Thr 
            180                 185                 190         


Thr Ser Leu Gly Ala Gly Pro Thr Ser Ile Ser Ala Val Gly Val Leu 
        195                 200                 205             


Ala Pro His Ser Ala Leu Ala Val Leu Glu Asp Thr Val Asp Tyr Pro 
    210                 215                 220                 


Ala Arg Ala His Thr Phe Asp Asp Phe Cys Pro Glu Cys Arg Thr Leu 
225                 230                 235                 240 


Gly Leu Gln Gly Cys Ala Phe Gln Ser Thr Ile Ala Glu Leu Gln Arg 
                245                 250                 255     


Leu Lys Met Lys Val Gly Lys Thr Arg Glu Ser 
            260                 265         


<210>  45
<211>  267
<212>  PRT
<213>  artificial sequence

<220>
<223>  Hepatitis E virus

<400>  45

Gln Leu Phe Tyr Ser Arg Pro Val Val Ser Ala Asn Gly Glu Pro Thr 
1               5                   10                  15      


Val Lys Leu Tyr Thr Ser Val Glu Asn Ala Gln Gln Asp Lys Gly Ile 
            20                  25                  30          


Ala Ile Pro His Asp Ile Asp Leu Gly Glu Ser Arg Val Val Ile Gln 
        35                  40                  45              


Asp Tyr Asp Asn Gln His Glu Gln Asp Arg Pro Thr Pro Ser Pro Ala 
    50                  55                  60                  


Pro Ser Arg Pro Phe Ser Val Leu Arg Ala Asn Asp Val Leu Trp Leu 
65                  70                  75                  80  


Ser Leu Thr Ala Ala Glu Tyr Asp Gln Thr Thr Tyr Gly Ser Ser Thr 
                85                  90                  95      


Asn Pro Met Tyr Val Ser Asp Thr Val Thr Phe Val Asn Val Ala Thr 
            100                 105                 110         


Gly Thr Gln Gly Val Ser Arg Ser Leu Asp Trp Ser Lys Val Thr Leu 
        115                 120                 125             


Asp Gly Arg Pro Leu Thr Thr Ile Gln Gln Tyr Ser Lys Thr Phe Phe 
    130                 135                 140                 


Val Leu Pro Leu Arg Gly Lys Leu Ser Phe Trp Glu Ala Gly Thr Thr 
145                 150                 155                 160 


Lys Ala Gly Tyr Pro Tyr Asn Tyr Asn Thr Thr Ala Ser Asp Gln Ile 
                165                 170                 175     


Leu Ile Glu Asn Ala Pro Gly His Arg Val Cys Ile Ser Thr Tyr Thr 
            180                 185                 190         


Thr Asn Leu Gly Ser Gly Pro Val Ser Ile Ser Ala Val Gly Val Leu 
        195                 200                 205             


Ala Pro His Ser Ala Leu Ala Ala Leu Glu Asp Thr Val Asp Tyr Pro 
    210                 215                 220                 


Ala Arg Ala His Thr Phe Asp Asp Phe Cys Pro Glu Cys Arg Ala Leu 
225                 230                 235                 240 


Gly Leu Gln Gly Cys Ala Phe Gln Ser Thr Val Ala Glu Leu Gln Arg 
                245                 250                 255     


Leu Lys Met Lys Val Gly Lys Thr Gln Glu Tyr 
            260                 265         


<210>  46
<211>  267
<212>  PRT
<213>  artificial sequence

<220>
<223>  Hepatitis E virus

<400>  46

Gln Leu Phe Tyr Ser Arg Pro Val Val Ser Ala Asn Gly Glu Pro Thr 
1               5                   10                  15      


Val Lys Leu Tyr Thr Ser Val Glu Asn Ala Gln Gln Asp Lys Gly Ile 
            20                  25                  30          


Ala Ile Pro His Asp Ile Asp Leu Gly Glu Ser Arg Val Val Ile Gln 
        35                  40                  45              


Asp Tyr Asp Asn Gln His Glu Gln Asp Arg Pro Thr Pro Ser Pro Ala 
    50                  55                  60                  


Pro Ser Arg Pro Phe Ser Val Leu Arg Ala Asn Asp Val Leu Trp Leu 
65                  70                  75                  80  


Ser Leu Thr Ala Ala Glu Tyr Asp Gln Ser Thr Tyr Gly Ser Ser Thr 
                85                  90                  95      


Gly Pro Val Tyr Val Ser Asp Ser Val Thr Leu Val Asn Val Ala Thr 
            100                 105                 110         


Gly Ala Gln Ala Val Ala Arg Ser Leu Asp Trp Thr Lys Val Thr Leu 
        115                 120                 125             


Asp Gly Arg Pro Leu Ser Thr Ile Gln Gln Tyr Ser Lys Thr Phe Phe 
    130                 135                 140                 


Val Leu Pro Leu Arg Gly Lys Leu Ser Phe Trp Glu Ala Gly Thr Thr 
145                 150                 155                 160 


Lys Ala Gly Tyr Pro Tyr Asn Tyr Asn Thr Thr Ala Ser Asp Gln Leu 
                165                 170                 175     


Leu Ile Glu Asn Ala Ala Gly His Arg Val Ala Ile Ser Thr Tyr Thr 
            180                 185                 190         


Thr Ser Leu Gly Ala Gly Pro Val Ala Ile Ser Ala Val Ala Val Leu 
        195                 200                 205             


Ala Pro His Ser Ala Leu Ala Leu Leu Glu Asp Thr Met Asp Tyr Pro 
    210                 215                 220                 


Ala Arg Ala His Thr Phe Asp Asp Phe Cys Pro Glu Cys Arg Pro Leu 
225                 230                 235                 240 


Gly Leu Gln Gly Cys Ala Phe Gln Ser Thr Val Ala Glu Leu Gln Arg 
                245                 250                 255     


Leu Lys Met Lys Val Gly Lys Thr Arg Glu Leu 
            260                 265         


<210>  47
<211>  267
<212>  PRT
<213>  artificial sequence

<220>
<223>  Hepatitis E virus

<400>  47

Gln Leu Phe Tyr Ser Arg Pro Val Ala Ser Ala Asn Gly Glu Pro Thr 
1               5                   10                  15      


Val Lys Leu Tyr Thr Ser Val Glu Asn Ala Gln Gln Asp Lys Gly Ile 
            20                  25                  30          


Thr Ile Pro His Asp Ile Asp Leu Gly Asp Ser Arg Val Val Ile Gln 
        35                  40                  45              


Asp Tyr Asp Asn Gln His Glu Gln Asp Arg Pro Thr Pro Ser Pro Ala 
    50                  55                  60                  


Pro Ser Arg Pro Phe Ser Val Leu Arg Ala Asn Asp Val Leu Trp Leu 
65                  70                  75                  80  


Ser Leu Thr Val Ala Glu Tyr Asp Gln Thr Thr Tyr Gly Ser Ser Thr 
                85                  90                  95      


Asn Pro Met Tyr Val Ser Asp Thr Ala Thr Phe Val Asn Val Ala Thr 
            100                 105                 110         


Gly Ala Gln Ala Val Ala Arg Ser Leu Asp Trp Ser Lys Val Thr Leu 
        115                 120                 125             


Asp Gly Arg Pro Leu Thr Thr Ile Gln Gln Tyr Ser Lys Thr Phe Tyr 
    130                 135                 140                 


Val Leu Pro Leu Arg Gly Lys Leu Ser Phe Trp Glu Ala Gly Thr Thr 
145                 150                 155                 160 


Lys Ala Gly Tyr Pro Tyr Asn Tyr Asn Thr Ala Ala Ser Asp Gln Ile 
                165                 170                 175     


Leu Ile Glu Asn Ala Ala Gly His Arg Val Ala Ile Ser Thr Tyr Thr 
            180                 185                 190         


Thr Ser Leu Gly Ala Ser Pro Thr Ser Ile Ser Ala Val Gly Val Leu 
        195                 200                 205             


Ala Pro His Ser Ala Leu Ala Val Leu Glu Asp Thr Val Asp Tyr Pro 
    210                 215                 220                 


Ala Arg Ala His Thr Phe Asp Asp Phe Cys Pro Glu Cys Arg Thr Leu 
225                 230                 235                 240 


Gly Leu Gln Gly Cys Ala Phe Gln Ser Thr Ile Ala Glu Leu Gln Arg 
                245                 250                 255     


Leu Lys Met Lys Val Gly Lys Thr Arg Glu Ser 
            260                 265         


<210>  48
<211>  267
<212>  PRT
<213>  artificial sequence

<220>
<223>  Hepatitis E virus

<400>  48

Gln Leu Phe Tyr Ser Arg Pro Val Val Ser Ala Asn Gly Glu Pro Thr 
1               5                   10                  15      


Val Lys Leu Tyr Thr Ser Val Glu Asn Ala Gln Gln Asp Lys Gly Ile 
            20                  25                  30          


Thr Ile Pro His Asp Ile Asp Leu Gly Asp Ser Arg Val Val Ile Gln 
        35                  40                  45              


Asp Tyr Asp Asn Gln His Glu Gln Asp Arg Pro Thr Pro Ser Pro Ala 
    50                  55                  60                  


Pro Ser Arg Pro Phe Ser Val Leu Arg Ala Asn Asp Val Leu Trp Leu 
65                  70                  75                  80  


Ser Leu Thr Ala Ala Glu Tyr Asp Gln Thr Thr Tyr Gly Ser Ser Thr 
                85                  90                  95      


Asn Pro Met Tyr Val Ser Asp Thr Val Thr Leu Val Asn Val Ala Thr 
            100                 105                 110         


Gly Ala Gln Ala Val Ala Arg Ser Leu Asp Trp Ser Lys Val Thr Leu 
        115                 120                 125             


Asp Gly Arg Pro Leu Thr Thr Ile Gln Gln Tyr Ser Lys Thr Phe Tyr 
    130                 135                 140                 


Val Leu Pro Leu Arg Gly Lys Leu Ser Phe Trp Glu Ala Gly Thr Thr 
145                 150                 155                 160 


Lys Ala Gly Tyr Pro Tyr Asn Tyr Asn Thr Thr Ala Ser Asp Gln Ile 
                165                 170                 175     


Leu Ile Glu Asn Ala Ser Gly His Arg Val Ala Ile Ser Thr Tyr Thr 
            180                 185                 190         


Thr Ser Leu Gly Ala Gly Pro Thr Ser Ile Ser Ala Val Gly Val Leu 
        195                 200                 205             


Ala Pro His Ser Ala Leu Ala Val Leu Glu Asp Thr Ile Asp Tyr Pro 
    210                 215                 220                 


Ala Arg Ala His Thr Phe Asp Asp Phe Cys Pro Glu Cys Arg Ala Leu 
225                 230                 235                 240 


Gly Phe Gln Gly Cys Ala Phe Gln Ser Thr Ile Ala Glu Leu Gln Arg 
                245                 250                 255     


Leu Lys Met Lys Val Gly Lys Thr Arg Glu Ser 
            260                 265         


<210>  49
<211>  267
<212>  PRT
<213>  artificial sequence

<220>
<223>  Hepatitis E virus

<400>  49

Gln Leu Phe Tyr Ser Arg Pro Val Val Ser Ala Asn Gly Glu Pro Thr 
1               5                   10                  15      


Val Lys Leu Tyr Thr Ser Val Glu Asn Ala Gln Gln Asp Lys Gly Ile 
            20                  25                  30          


Thr Ile Pro His Asp Ile Asp Leu Gly Asp Ser Arg Val Val Ile Gln 
        35                  40                  45              


Asp Tyr Asp Asn Gln His Glu Gln Asp Arg Pro Thr Pro Ser Pro Ala 
    50                  55                  60                  


Pro Ser Arg Pro Phe Ser Val Leu Arg Ala Asn Asp Val Leu Trp Leu 
65                  70                  75                  80  


Ser Leu Thr Ala Ala Glu Tyr Asp Gln Thr Thr Tyr Gly Ser Ser Thr 
                85                  90                  95      


Asn Pro Met Tyr Val Ser Asp Thr Val Thr Phe Val Asn Val Ala Thr 
            100                 105                 110         


Gly Ala Gln Ala Val Ala Arg Ser Leu Asp Trp Ser Lys Val Thr Leu 
        115                 120                 125             


Asp Gly Arg Pro Leu Thr Thr Ile Gln Gln Tyr Ser Lys Thr Phe Tyr 
    130                 135                 140                 


Val Leu Pro Leu Arg Gly Lys Leu Ser Phe Trp Glu Ala Gly Thr Thr 
145                 150                 155                 160 


Lys Ala Gly Tyr Pro Tyr Asn Tyr Asn Thr Thr Ala Ser Asp Gln Ile 
                165                 170                 175     


Leu Ile Glu Asn Ala Ala Gly His Arg Val Ala Ile Ser Thr Tyr Thr 
            180                 185                 190         


Thr Ser Leu Gly Ala Gly Pro Thr Ser Ile Ser Ala Val Gly Val Leu 
        195                 200                 205             


Ala Pro His Ser Ala Leu Ala Val Leu Glu Asp Thr Val Asp Tyr Pro 
    210                 215                 220                 


Ala Arg Ala His Thr Phe Asp Asp Phe Cys Pro Glu Cys Arg Ala Leu 
225                 230                 235                 240 


Gly Leu Gln Gly Cys Ala Phe Gln Ser Thr Val Ala Glu Leu Gln Arg 
                245                 250                 255     


Leu Lys Met Lys Val Gly Lys Thr Arg Glu Ser 
            260                 265         


<210>  50
<211>  267
<212>  PRT
<213>  artificial sequence

<220>
<223>  Hepatitis E virus

<400>  50

Gln Leu Phe Tyr Ser Arg Pro Val Val Ser Ala Asn Gly Glu Pro Thr 
1               5                   10                  15      


Val Lys Leu Tyr Thr Ser Val Glu Asn Ala Gln Gln Asp Lys Gly Val 
            20                  25                  30          


Ala Ile Pro His Asp Ile Asp Leu Gly Asp Ser Arg Val Val Ile Gln 
        35                  40                  45              


Asp Tyr Asp Asn Gln His Glu Gln Asp Arg Pro Thr Pro Ser Pro Ala 
    50                  55                  60                  


Pro Ser Arg Pro Phe Ser Val Leu Arg Ala Asn Asp Val Leu Trp Leu 
65                  70                  75                  80  


Ser Leu Thr Ala Ala Glu Tyr Asp Gln Ser Thr Tyr Gly Ser Ser Thr 
                85                  90                  95      


Gly Pro Val Tyr Ile Ser Asp Ser Val Thr Leu Val Asn Val Ala Thr 
            100                 105                 110         


Gly Ala Gln Ala Val Ala Arg Ser Leu Asp Trp Ser Lys Val Thr Leu 
        115                 120                 125             


Asp Gly Arg Pro Leu Pro Thr Val Glu Gln Tyr Ser Lys Thr Phe Phe 
    130                 135                 140                 


Val Leu Pro Leu Arg Gly Lys Leu Ser Phe Trp Glu Ala Gly Thr Thr 
145                 150                 155                 160 


Lys Ala Gly Tyr Pro Tyr Asn Tyr Asn Thr Thr Ala Ser Asp Gln Ile 
                165                 170                 175     


Leu Ile Glu Asn Ala Ala Gly His Arg Val Ala Ile Ser Thr Tyr Thr 
            180                 185                 190         


Thr Arg Leu Gly Ala Gly Pro Val Ala Ile Ser Ala Ala Ala Val Leu 
        195                 200                 205             


Ala Pro Arg Ser Ala Leu Ala Leu Leu Glu Asp Thr Phe Asp Tyr Pro 
    210                 215                 220                 


Gly Arg Ala His Thr Phe Asp Asp Phe Cys Pro Glu Cys Arg Ala Leu 
225                 230                 235                 240 


Gly Leu Gln Gly Cys Ala Phe Gln Ser Thr Val Ala Glu Leu Gln Arg 
                245                 250                 255     


Leu Lys Val Lys Val Gly Lys Thr Arg Glu Leu 
            260                 265         


