               SEQUENCE LISTING

<110> BOEHRINGER INGELHEIM INTERNATIONAL GMBH

<120> BIPARATOPIC POLYPEPTIDES ANTAGONIZING WNT SIGNALING IN TUMOR CELLS 

<130> P12-0401/WO/1

<160> 47

<170> BiSSAP 1.2

<210> 1
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR1 of Wnt1-333E06mod

<400> 1
Thr Tyr Thr Val Gly 
1               5   

<210> 2
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR2 of Wnt1-333E06mod

<400> 2
Ala Ile Arg Arg Arg Gly Ser Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      
Gly 
    

<210> 3
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR3 of Wnt1-333E06mod

<400> 3
Asp Thr Arg Thr Val Ala Leu Leu Gln Tyr Arg Tyr Asp Tyr 
1               5                   10                  

<210> 4
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR1 of Wnt1-333G06

<400> 4
Ser Tyr Ala Met Gly 
1               5   

<210> 5
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR2 of Wnt1-333G06

<400> 5
Ala Ile Arg Arg Ser Gly Arg Arg Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      
Gly 
    

<210> 6
<211> 19
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR3 of Wnt1-333G06

<400> 6
Ala Arg Arg Val Arg Ser Ser Thr Arg Tyr Asn Thr Gly Thr Trp Trp 
1               5                   10                  15      
Trp Glu Tyr 
            

<210> 7
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR1 of Wnt1-332D03mod

<400> 7
Arg Tyr Thr Met Gly 
1               5   

<210> 8
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR2 of Wnt1-332D03mod

<400> 8
Ala Ile Val Arg Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      
Gly 
    

<210> 9
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR3 of Wnt1-332D03mod

<400> 9
Asp Arg Arg Gly Arg Gly Glu Asn Tyr Ile Leu Leu Tyr Ser Ser Gly 
1               5                   10                  15      
Arg Tyr Glu Tyr 
            20  

<210> 10
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR1 of Wnt3a-093A01

<400> 10
Ser Tyr Ala Met Gly 
1               5   

<210> 11
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR2 of Wnt3a-093A01

<400> 11
Ala Ile Ser Trp Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      
Gly 
    

<210> 12
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR3 of Wnt3a-093A01

<400> 12
Ser Pro Ile Pro Tyr Gly Ser Leu Leu Arg Arg Arg Asn Asn Tyr Asp 
1               5                   10                  15      
Tyr 
    

<210> 13
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR1 of Wnt3a-367B10

<400> 13
Ser Tyr Ala Met Gly 
1               5   

<210> 14
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR2 of Wnt3a-367B10

<400> 14
Ala Ile Ser Trp Arg Ser Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      
Gly 
    

<210> 15
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR3 of Wnt3a-367B10

<400> 15
Asp Pro Arg Gly Tyr Gly Val Ala Tyr Val Ser Ala Tyr Tyr Glu Tyr 
1               5                   10                  15      



<210> 16
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR1 of Alb11

<400> 16
Ser Phe Gly Met Ser 
1               5   

<210> 17
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR2 of Alb11

<400> 17
Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      
Gly 
    

<210> 18
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR3 of Alb11

<400> 18
Gly Gly Ser Leu Ser Arg 
1               5       

<210> 19
<211> 123
<212> PRT
<213> Artificial Sequence

<220> 
<223> VHH domain Wnt1-333E06mod

<400> 19
Ala Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Thr Tyr 
            20                  25                  30          
Thr Val Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              
Ala Ala Ile Arg Arg Arg Gly Ser Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Asp Thr Arg Thr Val Ala Leu Leu Gln Tyr Arg Tyr Asp Tyr 
            100                 105                 110         
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             

<210> 20
<211> 128
<212> PRT
<213> Artificial Sequence

<220> 
<223> VHH domain Wnt1-333G06

<400> 20
Ala Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          
Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              
Ala Ala Ile Arg Arg Ser Gly Arg Arg Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Ala Arg Arg Val Arg Ser Ser Thr Arg Tyr Asn Thr Gly Thr 
            100                 105                 110         
Trp Trp Trp Glu Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125             



<210> 21
<211> 129
<212> PRT
<213> Artificial Sequence

<220> 
<223> VHH domain Wnt1-332D03mod

<400> 21
Ala Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Phe Ser Arg Tyr 
            20                  25                  30          
Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              
Ala Ala Ile Val Arg Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Asp Arg Arg Gly Arg Gly Glu Asn Tyr Ile Leu Leu Tyr Ser 
            100                 105                 110         
Ser Gly Arg Tyr Glu Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        115                 120                 125             
Ser 
    

<210> 22
<211> 126
<212> PRT
<213> Artificial Sequence

<220> 
<223> VHH domain Wnt3a-093A01

<400> 22
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Ser Tyr 
            20                  25                  30          
Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              
Ala Ala Ile Ser Trp Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Ser Pro Ile Pro Tyr Gly Ser Leu Leu Arg Arg Arg Asn Asn 
            100                 105                 110         
Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     

<210> 23
<211> 125
<212> PRT
<213> Artificial Sequence

<220> 
<223> VHH domain Wnt3a-367B10

<400> 23
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          
Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              
Ala Ala Ile Ser Trp Arg Ser Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Asp Pro Arg Gly Tyr Gly Val Ala Tyr Val Ser Ala Tyr Tyr 
            100                 105                 110         
Glu Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 

<210> 24
<211> 115
<212> PRT
<213> Artificial Sequence

<220> 
<223> VHH domain Alb11

<400> 24
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Asn 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 
            20                  25                  30          
Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr 
            100                 105                 110         
Val Ser Ser 
        115 

<210> 25
<211> 435
<212> PRT
<213> Artificial Sequence

<220> 
<223> VHH construct F013500575

<400> 25
Ala Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Thr Tyr 
            20                  25                  30          
Thr Val Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              
Ala Ala Ile Arg Arg Arg Gly Ser Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Asp Thr Arg Thr Val Ala Leu Leu Gln Tyr Arg Tyr Asp Tyr 
            100                 105                 110         
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
        115                 120                 125             
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 
Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
145                 150                 155                 160 
Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Asn Ser Leu 
                165                 170                 175     
Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe Gly Met 
            180                 185                 190         
Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser 
        195                 200                 205             
Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val Lys Gly 
    210                 215                 220                 
Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr Leu Gln 
225                 230                 235                 240 
Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Thr Ile 
                245                 250                 255     
Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr Val Ser 
            260                 265                 270         
Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        275                 280                 285             
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    290                 295                 300                 
Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
305                 310                 315                 320 
Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr 
                325                 330                 335     
Phe Ser Ser Tyr Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu 
            340                 345                 350         
Arg Glu Phe Val Ala Ala Ile Ser Trp Ser Gly Gly Ser Thr Tyr Tyr 
        355                 360                 365             
Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys 
    370                 375                 380                 
Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala 
385                 390                 395                 400 
Val Tyr Tyr Cys Ala Ala Ser Pro Ile Pro Tyr Gly Ser Leu Leu Arg 
                405                 410                 415     
Arg Arg Asn Asn Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
            420                 425                 430         
Ser Ser Ala 
        435 

<210> 26
<211> 439
<212> PRT
<213> Artificial Sequence

<220> 
<223> VHH construct F013500571

<400> 26
Ala Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          
Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              
Ala Ala Ile Arg Arg Ser Gly Arg Arg Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Ala Arg Arg Val Arg Ser Ser Thr Arg Tyr Asn Thr Gly Thr 
            100                 105                 110         
Trp Trp Trp Glu Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125             
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 
Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 
Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
                165                 170                 175     
Pro Gly Asn Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
            180                 185                 190         
Ser Ser Phe Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
        195                 200                 205             
Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala 
    210                 215                 220                 
Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr 
225                 230                 235                 240 
Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val 
                245                 250                 255     
Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr 
            260                 265                 270         
Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        275                 280                 285             
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    290                 295                 300                 
Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 
305                 310                 315                 320 
Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala 
                325                 330                 335     
Ala Ser Gly Gly Thr Phe Ser Ser Tyr Ala Met Gly Trp Phe Arg Gln 
            340                 345                 350         
Ala Pro Gly Lys Glu Arg Glu Phe Val Ala Ala Ile Ser Trp Arg Ser 
        355                 360                 365             
Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser 
    370                 375                 380                 
Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg 
385                 390                 395                 400 
Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala Asp Pro Arg Gly Tyr 
                405                 410                 415     
Gly Val Ala Tyr Val Ser Ala Tyr Tyr Glu Tyr Trp Gly Gln Gly Thr 
            420                 425                 430         
Leu Val Thr Val Ser Ser Ala 
        435                 

<210> 27
<211> 440
<212> PRT
<213> Artificial Sequence

<220> 
<223> VHH construct F013500720

<400> 27
Ala Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Phe Ser Arg Tyr 
            20                  25                  30          
Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              
Ala Ala Ile Val Arg Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Asp Arg Arg Gly Arg Gly Glu Asn Tyr Ile Leu Leu Tyr Ser 
            100                 105                 110         
Ser Gly Arg Tyr Glu Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        115                 120                 125             
Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
145                 150                 155                 160 
Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
                165                 170                 175     
Gln Pro Gly Asn Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr 
            180                 185                 190         
Phe Ser Ser Phe Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly 
        195                 200                 205             
Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr 
    210                 215                 220                 
Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys 
225                 230                 235                 240 
Thr Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala 
                245                 250                 255     
Val Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly 
            260                 265                 270         
Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        275                 280                 285             
Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    290                 295                 300                 
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu 
305                 310                 315                 320 
Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
                325                 330                 335     
Ala Ala Ser Gly Gly Thr Phe Ser Ser Tyr Ala Met Gly Trp Phe Arg 
            340                 345                 350         
Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ala Ala Ile Ser Trp Arg 
        355                 360                 365             
Ser Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
    370                 375                 380                 
Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu 
385                 390                 395                 400 
Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala Asp Pro Arg Gly 
                405                 410                 415     
Tyr Gly Val Ala Tyr Val Ser Ala Tyr Tyr Glu Tyr Trp Gly Gln Gly 
            420                 425                 430         
Thr Leu Val Thr Val Ser Ser Ala 
        435                 440 

<210> 28
<211> 149
<212> PRT
<213> Artificial Sequence

<220> 
<223> VHH domain F0129093A01

<400> 28
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Ser Tyr 
            20                  25                  30          
Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              
Ala Ala Ile Ser Trp Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Ser Pro Ile Pro Tyr Gly Ser Leu Leu Arg Arg Arg Asn Asn 
            100                 105                 110         
Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ala 
        115                 120                 125             
Ala Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Asn Gly Ala Ala His 
    130                 135                 140                 
His His His His His 
145                 

<210> 29
<211> 151
<212> PRT
<213> Artificial Sequence

<220> 
<223> VHH domain F0130333G06

<400> 29
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          
Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              
Ala Ala Ile Arg Arg Ser Gly Arg Arg Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Ala Arg Arg Val Arg Ser Ser Thr Arg Tyr Asn Thr Gly Thr 
            100                 105                 110         
Trp Trp Trp Glu Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125             
Ala Ala Ala Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Asn Gly Ala 
    130                 135                 140                 
Ala His His His His His His 
145                 150     

<210> 30
<211> 148
<212> PRT
<213> Artificial Sequence

<220> 
<223> VHH domain F0129093A03

<400> 30
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Thr Tyr 
            20                  25                  30          
Val Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              
Ala Ala Ile Asn Trp Ser Gly Ser Arg Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Ser Arg Ser Ser Tyr Ala Gly Arg Thr Tyr Tyr Glu Leu Tyr 
            100                 105                 110         
Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ala Ala 
        115                 120                 125             
Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Asn Gly Ala Ala His His 
    130                 135                 140                 
His His His His 
145             

<210> 31
<211> 146
<212> PRT
<213> Artificial Sequence

<220> 
<223> VHH domain F0130333E06

<400> 31
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Thr Tyr 
            20                  25                  30          
Thr Val Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              
Ala Ala Ile Arg Arg Arg Gly Ser Ser Thr Tyr Tyr Ser Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Asp Thr Arg Thr Val Ala Leu Leu Gln Tyr Arg Tyr Asp Tyr 
            100                 105                 110         
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ala Ala Glu Gln 
        115                 120                 125             
Lys Leu Ile Ser Glu Glu Asp Leu Asn Gly Ala Ala His His His His 
    130                 135                 140                 
His His 
145     

<210> 32
<211> 152
<212> PRT
<213> Artificial Sequence

<220> 
<223> VHH domain F0130332D03

<400> 32
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Phe Ser Arg Tyr 
            20                  25                  30          
Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              
Ala Ala Ile Asn Arg Ser Gly Gly Ser Thr Tyr Tyr Ser Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Asp Arg Arg Gly Arg Gly Glu Asn Tyr Ser Leu Leu Tyr Ser 
            100                 105                 110         
Ser Asn Arg Tyr Glu Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        115                 120                 125             
Ser Ala Ala Ala Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Asn Gly 
    130                 135                 140                 
Ala Ala His His His His His His 
145                 150         

<210> 33
<211> 148
<212> PRT
<213> Artificial Sequence

<220> 
<223> VHH domain F0130367B10

<400> 33
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          
Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              
Ala Ala Ile Ser Trp Arg Ser Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Pro Glu Gly Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Asp Pro Arg Gly Tyr Gly Val Ala Tyr Val Ser Ala Tyr Tyr 
            100                 105                 110         
Glu Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Ala Ala 
        115                 120                 125             
Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Asn Gly Ala Ala His His 
    130                 135                 140                 
His His His His 
145             

<210> 34
<211> 149
<212> PRT
<213> Artificial Sequence

<220> 
<223> VHH domain F0130378B05

<400> 34
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Arg Thr Phe Ser Ser Tyr 
            20                  25                  30          
Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              
Ala Ala Ile Ser Arg Ser Gly Gly Arg Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Asp Arg Arg Val Tyr Ser Thr Leu Pro Pro Thr Thr Ser Arg 
            100                 105                 110         
Tyr Asn Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ala 
        115                 120                 125             
Ala Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Asn Gly Ala Ala His 
    130                 135                 140                 
His His His His His 
145                 

<210> 35
<211> 147
<212> PRT
<213> Artificial Sequence

<220> 
<223> VHH domain F0130378A04

<400> 35
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Ser Tyr 
            20                  25                  30          
Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              
Ala Ala Ile Thr Arg Thr Gly Arg Arg Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Asp Arg Arg Gly Tyr Tyr Tyr Tyr Asp Ser Ser Phe Tyr Asp 
            100                 105                 110         
Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ala Ala Glu 
        115                 120                 125             
Gln Lys Leu Ile Ser Glu Glu Asp Leu Asn Gly Ala Ala His His His 
    130                 135                 140                 
His His His 
145         

<210> 36
<211> 150
<212> PRT
<213> Artificial Sequence

<220> 
<223> VHH domain F0130372C08

<400> 36
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Asp Tyr 
            20                  25                  30          
Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              
Ala Ala Ile Ser Trp Ser Gly Gly Arg Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Lys Arg Arg Gly Arg Gly Ser Val Ser Pro Asn Ser Ser Ser 
            100                 105                 110         
Arg Tyr Asn Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala 
        115                 120                 125             
Ala Ala Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Asn Gly Ala Ala 
    130                 135                 140                 
His His His His His His 
145                 150 

<210> 37
<211> 462
<212> PRT
<213> Artificial Sequence

<220> 
<223> VHH construct F013500016

<400> 37
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Phe Ser Arg Tyr 
            20                  25                  30          
Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              
Ala Ala Ile Asn Arg Ser Gly Gly Ser Thr Tyr Tyr Ser Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Asp Arg Arg Gly Arg Gly Glu Asn Tyr Ser Leu Leu Tyr Ser 
            100                 105                 110         
Ser Asn Arg Tyr Glu Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        115                 120                 125             
Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
145                 150                 155                 160 
Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
                165                 170                 175     
Gln Pro Gly Asn Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr 
            180                 185                 190         
Phe Ser Ser Phe Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly 
        195                 200                 205             
Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr 
    210                 215                 220                 
Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys 
225                 230                 235                 240 
Thr Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala 
                245                 250                 255     
Val Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly 
            260                 265                 270         
Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        275                 280                 285             
Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    290                 295                 300                 
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu 
305                 310                 315                 320 
Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
                325                 330                 335     
Ala Ala Ser Gly Gly Thr Phe Ser Ser Tyr Ala Met Gly Trp Phe Arg 
            340                 345                 350         
Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ala Ala Ile Ser Trp Arg 
        355                 360                 365             
Ser Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
    370                 375                 380                 
Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu 
385                 390                 395                 400 
Arg Pro Glu Gly Thr Ala Val Tyr Tyr Cys Ala Ala Asp Pro Arg Gly 
                405                 410                 415     
Tyr Gly Val Ala Tyr Val Ser Ala Tyr Tyr Glu Tyr Trp Gly Gln Gly 
            420                 425                 430         
Thr Leu Val Thr Val Ser Ser Gly Ala Ala Glu Gln Lys Leu Ile Ser 
        435                 440                 445             
Glu Glu Asp Leu Asn Gly Ala Ala His His His His His His 
    450                 455                 460         

<210> 38
<211> 463
<212> PRT
<213> Artificial Sequence

<220> 
<223> VHH construct F013500018

<400> 38
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Phe Ser Arg Tyr 
            20                  25                  30          
Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              
Ala Ala Ile Asn Arg Ser Gly Gly Ser Thr Tyr Tyr Ser Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Asp Arg Arg Gly Arg Gly Glu Asn Tyr Ser Leu Leu Tyr Ser 
            100                 105                 110         
Ser Asn Arg Tyr Glu Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        115                 120                 125             
Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
145                 150                 155                 160 
Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
                165                 170                 175     
Gln Pro Gly Asn Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr 
            180                 185                 190         
Phe Ser Ser Phe Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly 
        195                 200                 205             
Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr 
    210                 215                 220                 
Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys 
225                 230                 235                 240 
Thr Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala 
                245                 250                 255     
Val Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly 
            260                 265                 270         
Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        275                 280                 285             
Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    290                 295                 300                 
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu 
305                 310                 315                 320 
Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
                325                 330                 335     
Val Ala Ser Gly Arg Thr Phe Ser Ser Tyr Ala Met Gly Trp Phe Arg 
            340                 345                 350         
Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ala Ala Ile Ser Arg Ser 
        355                 360                 365             
Gly Gly Arg Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
    370                 375                 380                 
Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu 
385                 390                 395                 400 
Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala Asp Arg Arg Val 
                405                 410                 415     
Tyr Ser Thr Leu Pro Pro Thr Thr Ser Arg Tyr Asn Tyr Trp Gly Gln 
            420                 425                 430         
Gly Thr Leu Val Thr Val Ser Ser Gly Ala Ala Glu Gln Lys Leu Ile 
        435                 440                 445             
Ser Glu Glu Asp Leu Asn Gly Ala Ala His His His His His His 
    450                 455                 460             

<210> 39
<211> 461
<212> PRT
<213> Artificial Sequence

<220> 
<223> VHH construct F013500021

<400> 39
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          
Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              
Ala Ala Ile Arg Arg Ser Gly Arg Arg Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Ala Arg Arg Val Arg Ser Ser Thr Arg Tyr Asn Thr Gly Thr 
            100                 105                 110         
Trp Trp Trp Glu Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125             
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 
Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 
Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
                165                 170                 175     
Pro Gly Asn Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
            180                 185                 190         
Ser Ser Phe Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
        195                 200                 205             
Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala 
    210                 215                 220                 
Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr 
225                 230                 235                 240 
Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val 
                245                 250                 255     
Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr 
            260                 265                 270         
Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        275                 280                 285             
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    290                 295                 300                 
Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 
305                 310                 315                 320 
Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala 
                325                 330                 335     
Ala Ser Gly Gly Thr Phe Ser Ser Tyr Ala Met Gly Trp Phe Arg Gln 
            340                 345                 350         
Ala Pro Gly Lys Glu Arg Glu Phe Val Ala Ala Ile Ser Trp Arg Ser 
        355                 360                 365             
Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser 
    370                 375                 380                 
Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg 
385                 390                 395                 400 
Pro Glu Gly Thr Ala Val Tyr Tyr Cys Ala Ala Asp Pro Arg Gly Tyr 
                405                 410                 415     
Gly Val Ala Tyr Val Ser Ala Tyr Tyr Glu Tyr Trp Gly Gln Gly Thr 
            420                 425                 430         
Leu Val Thr Val Ser Ser Gly Ala Ala Glu Gln Lys Leu Ile Ser Glu 
        435                 440                 445             
Glu Asp Leu Asn Gly Ala Ala His His His His His His 
    450                 455                 460     

<210> 40
<211> 456
<212> PRT
<213> Artificial Sequence

<220> 
<223> VHH construct F013500026

<400> 40
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Thr Tyr 
            20                  25                  30          
Thr Val Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              
Ala Ala Ile Arg Arg Arg Gly Ser Ser Thr Tyr Tyr Ser Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Asp Thr Arg Thr Val Ala Leu Leu Gln Tyr Arg Tyr Asp Tyr 
            100                 105                 110         
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
        115                 120                 125             
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 
Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
145                 150                 155                 160 
Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Asn Ser Leu 
                165                 170                 175     
Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe Gly Met 
            180                 185                 190         
Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser 
        195                 200                 205             
Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val Lys Gly 
    210                 215                 220                 
Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr Leu Gln 
225                 230                 235                 240 
Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Thr Ile 
                245                 250                 255     
Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr Val Ser 
            260                 265                 270         
Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        275                 280                 285             
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    290                 295                 300                 
Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
305                 310                 315                 320 
Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr 
                325                 330                 335     
Phe Ser Ser Tyr Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu 
            340                 345                 350         
Arg Glu Phe Val Ala Ala Ile Ser Trp Arg Ser Gly Ser Thr Tyr Tyr 
        355                 360                 365             
Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys 
    370                 375                 380                 
Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Gly Thr Ala 
385                 390                 395                 400 
Val Tyr Tyr Cys Ala Ala Asp Pro Arg Gly Tyr Gly Val Ala Tyr Val 
                405                 410                 415     
Ser Ala Tyr Tyr Glu Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            420                 425                 430         
Ser Gly Ala Ala Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Asn Gly 
        435                 440                 445             
Ala Ala His His His His His His 
    450                 455     

<210> 41
<211> 461
<212> PRT
<213> Artificial Sequence

<220> 
<223> VHH construct F013500030

<400> 41
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Arg Thr Phe Ser Ser Tyr 
            20                  25                  30          
Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              
Ala Ala Ile Ser Arg Ser Gly Gly Arg Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Asp Arg Arg Val Tyr Ser Thr Leu Pro Pro Thr Thr Ser Arg 
            100                 105                 110         
Tyr Asn Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
        115                 120                 125             
Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 
Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
145                 150                 155                 160 
Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
                165                 170                 175     
Asn Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser 
            180                 185                 190         
Phe Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        195                 200                 205             
Val Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser 
    210                 215                 220                 
Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu 
225                 230                 235                 240 
Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr 
                245                 250                 255     
Cys Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val 
            260                 265                 270         
Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        275                 280                 285             
Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    290                 295                 300                 
Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly 
305                 310                 315                 320 
Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
                325                 330                 335     
Gly Arg Thr Phe Ser Asp Tyr Gly Met Gly Trp Phe Arg Gln Ala Pro 
            340                 345                 350         
Gly Lys Glu Arg Glu Phe Val Ala Ala Ile Ser Trp Ser Gly Gly Arg 
        355                 360                 365             
Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
    370                 375                 380                 
Asn Ser Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu 
385                 390                 395                 400 
Asp Thr Ala Val Tyr Tyr Cys Ala Ala Lys Arg Arg Gly Arg Gly Ser 
                405                 410                 415     
Val Ser Pro Asn Ser Ser Ser Arg Tyr Asn Tyr Trp Gly Gln Gly Thr 
            420                 425                 430         
Leu Val Thr Val Ser Ser Gly Ala Ala Glu Gln Lys Leu Ile Ser Glu 
        435                 440                 445             
Glu Asp Leu Asn Gly Ala Ala His His His His His His 
    450                 455                 460     

<210> 42
<211> 460
<212> PRT
<213> Artificial Sequence

<220> 
<223> VHH construct F013500032

<400> 42
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Ser Tyr 
            20                  25                  30          
Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              
Ala Ala Ile Thr Arg Thr Gly Arg Arg Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Asp Arg Arg Gly Tyr Tyr Tyr Tyr Asp Ser Ser Phe Tyr Asp 
            100                 105                 110         
Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
        115                 120                 125             
Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
145                 150                 155                 160 
Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Asn Ser 
                165                 170                 175     
Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe Gly 
            180                 185                 190         
Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser 
        195                 200                 205             
Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val Lys 
    210                 215                 220                 
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr Leu 
225                 230                 235                 240 
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Thr 
                245                 250                 255     
Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr Val 
            260                 265                 270         
Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        275                 280                 285             
Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    290                 295                 300                 
Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
305                 310                 315                 320 
Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly 
                325                 330                 335     
Thr Phe Ser Ser Tyr Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys 
            340                 345                 350         
Glu Arg Glu Phe Val Ala Ala Ile Arg Arg Ser Gly Arg Arg Thr Tyr 
        355                 360                 365             
Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser 
    370                 375                 380                 
Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr 
385                 390                 395                 400 
Ala Val Tyr Tyr Cys Ala Ala Ala Arg Arg Val Arg Ser Ser Thr Arg 
                405                 410                 415     
Tyr Asn Thr Gly Thr Trp Trp Trp Glu Tyr Trp Gly Gln Gly Thr Leu 
            420                 425                 430         
Val Thr Val Ser Ser Gly Ala Ala Glu Gln Lys Leu Ile Ser Glu Glu 
        435                 440                 445             
Asp Leu Asn Gly Ala Ala His His His His His His 
    450                 455                 460 

<210> 43
<211> 462
<212> PRT
<213> Artificial Sequence

<220> 
<223> VHH construct F013500033

<400> 43
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Arg Thr Phe Ser Ser Tyr 
            20                  25                  30          
Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              
Ala Ala Ile Ser Arg Ser Gly Gly Arg Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Asp Arg Arg Val Tyr Ser Thr Leu Pro Pro Thr Thr Ser Arg 
            100                 105                 110         
Tyr Asn Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
        115                 120                 125             
Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 
Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
145                 150                 155                 160 
Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
                165                 170                 175     
Asn Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser 
            180                 185                 190         
Phe Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        195                 200                 205             
Val Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser 
    210                 215                 220                 
Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu 
225                 230                 235                 240 
Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr 
                245                 250                 255     
Cys Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val 
            260                 265                 270         
Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        275                 280                 285             
Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    290                 295                 300                 
Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly 
305                 310                 315                 320 
Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
                325                 330                 335     
Gly Gly Thr Phe Ser Ser Tyr Ala Met Gly Trp Phe Arg Gln Ala Pro 
            340                 345                 350         
Gly Lys Glu Arg Glu Phe Val Ala Ala Ile Arg Arg Ser Gly Arg Arg 
        355                 360                 365             
Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
    370                 375                 380                 
Asn Ser Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu 
385                 390                 395                 400 
Asp Thr Ala Val Tyr Tyr Cys Ala Ala Ala Arg Arg Val Arg Ser Ser 
                405                 410                 415     
Thr Arg Tyr Asn Thr Gly Thr Trp Trp Trp Glu Tyr Trp Gly Gln Gly 
            420                 425                 430         
Thr Leu Val Thr Val Ser Ser Gly Ala Ala Glu Gln Lys Leu Ile Ser 
        435                 440                 445             
Glu Glu Asp Leu Asn Gly Ala Ala His His His His His His 
    450                 455                 460         

<210> 44
<211> 456
<212> PRT
<213> Artificial Sequence

<220> 
<223> VHH construct F013500039

<400> 44
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Thr Tyr 
            20                  25                  30          
Val Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              
Ala Ala Ile Asn Trp Ser Gly Ser Arg Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Ser Arg Ser Ser Tyr Ala Gly Arg Thr Tyr Tyr Glu Leu Tyr 
            100                 105                 110         
Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             
Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 
Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
145                 150                 155                 160 
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Asn 
                165                 170                 175     
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 
            180                 185                 190         
Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        195                 200                 205             
Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val 
    210                 215                 220                 
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr 
225                 230                 235                 240 
Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                245                 250                 255     
Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr 
            260                 265                 270         
Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             
Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    290                 295                 300                 
Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
305                 310                 315                 320 
Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
                325                 330                 335     
Arg Thr Phe Ser Thr Tyr Thr Val Gly Trp Phe Arg Gln Ala Pro Gly 
            340                 345                 350         
Lys Glu Arg Glu Phe Val Ala Ala Ile Arg Arg Arg Gly Ser Ser Thr 
        355                 360                 365             
Tyr Tyr Ser Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
    370                 375                 380                 
Ser Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp 
385                 390                 395                 400 
Thr Ala Val Tyr Tyr Cys Ala Ala Asp Thr Arg Thr Val Ala Leu Leu 
                405                 410                 415     
Gln Tyr Arg Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            420                 425                 430         
Ser Gly Ala Ala Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Asn Gly 
        435                 440                 445             
Ala Ala His His His His His His 
    450                 455     

<210> 45
<211> 463
<212> PRT
<213> Artificial Sequence

<220> 
<223> VHH construct F013500046

<400> 45
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Phe Ser Arg Tyr 
            20                  25                  30          
Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              
Ala Ala Ile Asn Arg Ser Gly Gly Ser Thr Tyr Tyr Ser Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Asp Arg Arg Gly Arg Gly Glu Asn Tyr Ser Leu Leu Tyr Ser 
            100                 105                 110         
Ser Asn Arg Tyr Glu Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        115                 120                 125             
Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
145                 150                 155                 160 
Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
                165                 170                 175     
Gln Pro Gly Asn Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr 
            180                 185                 190         
Phe Ser Ser Phe Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly 
        195                 200                 205             
Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr 
    210                 215                 220                 
Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys 
225                 230                 235                 240 
Thr Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala 
                245                 250                 255     
Val Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly 
            260                 265                 270         
Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        275                 280                 285             
Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    290                 295                 300                 
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu 
305                 310                 315                 320 
Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
                325                 330                 335     
Ala Ala Ser Gly Arg Thr Phe Ser Ser Tyr Ala Met Gly Trp Phe Arg 
            340                 345                 350         
Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ala Ala Ile Ser Trp Ser 
        355                 360                 365             
Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
    370                 375                 380                 
Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu 
385                 390                 395                 400 
Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala Ser Pro Ile Pro 
                405                 410                 415     
Tyr Gly Ser Leu Leu Arg Arg Arg Asn Asn Tyr Asp Tyr Trp Gly Gln 
            420                 425                 430         
Gly Thr Leu Val Thr Val Ser Ser Gly Ala Ala Glu Gln Lys Leu Ile 
        435                 440                 445             
Ser Glu Glu Asp Leu Asn Gly Ala Ala His His His His His His 
    450                 455                 460             

<210> 46
<211> 457
<212> PRT
<213> Artificial Sequence

<220> 
<223> VHH construct F013500047

<400> 46
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Thr Tyr 
            20                  25                  30          
Thr Val Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              
Ala Ala Ile Arg Arg Arg Gly Ser Ser Thr Tyr Tyr Ser Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Asp Thr Arg Thr Val Ala Leu Leu Gln Tyr Arg Tyr Asp Tyr 
            100                 105                 110         
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
        115                 120                 125             
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 
Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
145                 150                 155                 160 
Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Asn Ser Leu 
                165                 170                 175     
Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe Gly Met 
            180                 185                 190         
Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser 
        195                 200                 205             
Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val Lys Gly 
    210                 215                 220                 
Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr Leu Gln 
225                 230                 235                 240 
Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Thr Ile 
                245                 250                 255     
Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr Val Ser 
            260                 265                 270         
Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        275                 280                 285             
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    290                 295                 300                 
Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
305                 310                 315                 320 
Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr 
                325                 330                 335     
Phe Ser Ser Tyr Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu 
            340                 345                 350         
Arg Glu Phe Val Ala Ala Ile Ser Trp Ser Gly Gly Ser Thr Tyr Tyr 
        355                 360                 365             
Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys 
    370                 375                 380                 
Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala 
385                 390                 395                 400 
Val Tyr Tyr Cys Ala Ala Ser Pro Ile Pro Tyr Gly Ser Leu Leu Arg 
                405                 410                 415     
Arg Arg Asn Asn Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
            420                 425                 430         
Ser Ser Gly Ala Ala Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Asn 
        435                 440                 445             
Gly Ala Ala His His His His His His 
    450                 455         

<210> 47
<211> 462
<212> PRT
<213> Artificial Sequence

<220> 
<223> VHH construct F013500053

<400> 47
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Ser Tyr 
            20                  25                  30          
Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              
Ala Ala Ile Ser Trp Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Ser Pro Ile Pro Tyr Gly Ser Leu Leu Arg Arg Arg Asn Asn 
            100                 105                 110         
Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
        115                 120                 125             
Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 
Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
145                 150                 155                 160 
Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
                165                 170                 175     
Asn Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser 
            180                 185                 190         
Phe Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        195                 200                 205             
Val Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser 
    210                 215                 220                 
Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu 
225                 230                 235                 240 
Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr 
                245                 250                 255     
Cys Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val 
            260                 265                 270         
Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        275                 280                 285             
Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    290                 295                 300                 
Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly 
305                 310                 315                 320 
Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
                325                 330                 335     
Gly Gly Thr Phe Ser Ser Tyr Ala Met Gly Trp Phe Arg Gln Ala Pro 
            340                 345                 350         
Gly Lys Glu Arg Glu Phe Val Ala Ala Ile Arg Arg Ser Gly Arg Arg 
        355                 360                 365             
Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
    370                 375                 380                 
Asn Ser Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu 
385                 390                 395                 400 
Asp Thr Ala Val Tyr Tyr Cys Ala Ala Ala Arg Arg Val Arg Ser Ser 
                405                 410                 415     
Thr Arg Tyr Asn Thr Gly Thr Trp Trp Trp Glu Tyr Trp Gly Gln Gly 
            420                 425                 430         
Thr Leu Val Thr Val Ser Ser Gly Ala Ala Glu Gln Lys Leu Ile Ser 
        435                 440                 445             
Glu Glu Asp Leu Asn Gly Ala Ala His His His His His His 
    450                 455                 460         

