                         SEQUENCE LISTING

<110>  UCB Biopharma sprl
 
<120>  Antibodies

<130>  PF0049_WO01

<150>  GB1521382.0
<151>  2015-12-03

<160>  103   

<170>  PatentIn version 3.5

<210>  1
<211>  44
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CN4(7P14P) sequence

<400>  1

Ala Ser Gly Gly Gly Arg Met Lys Gln Leu Glu Pro Lys Val Glu Glu 
1               5                   10                  15      


Leu Leu Pro Lys Asn Tyr His Leu Glu Asn Glu Val Ala Arg Leu Lys 
            20                  25                  30          


Lys Leu Val Gly Glu Arg His His His His His His 
        35                  40                  


<210>  2
<211>  132
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA encoding

<400>  2
gctagcggag gcggaagaat gaaacaactt gaacccaagg ttgaagaatt gcttccgaaa       60

aattatcact tggaaaatga ggttgccaga ttaaagaaat tagttggcga acgccatcac      120

catcaccatc ac                                                          132


<210>  3
<211>  262
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  52SR4 ds scFv sequence

<400>  3

Asp Ala Val Val Thr Gln Glu Ser Ala Leu Thr Ser Ser Pro Gly Glu 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Ser Trp Val Gln Glu Lys Pro Asp His Leu Phe Thr Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Ile Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Thr Glu Asp Glu Ala Ile Tyr Phe Cys Val Leu Trp Tyr Ser Asp 
                85                  90                  95      


His Trp Val Phe Gly Cys Gly Thr Lys Leu Thr Val Leu Gly Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Asp Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Ala Pro 
    130                 135                 140                 


Ser Gln Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Leu Leu Thr 
145                 150                 155                 160 


Asp Tyr Gly Val Asn Trp Val Arg Gln Ser Pro Gly Lys Cys Leu Glu 
                165                 170                 175     


Trp Leu Gly Val Ile Trp Gly Asp Gly Ile Thr Asp Tyr Asn Ser Ala 
            180                 185                 190         


Leu Lys Ser Arg Leu Ser Val Thr Lys Asp Asn Ser Lys Ser Gln Val 
        195                 200                 205             


Phe Leu Lys Met Asn Ser Leu Gln Ser Gly Asp Ser Ala Arg Tyr Tyr 
    210                 215                 220                 


Cys Val Thr Gly Leu Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr 
225                 230                 235                 240 


Val Ser Ser Ala Ala Ala His His His His His His Glu Gln Lys Leu 
                245                 250                 255     


Ile Ser Glu Glu Asp Leu 
            260         


<210>  4
<211>  792
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA encoding

<400>  4
gatgcggtgg tgacccagga aagcgcgctg accagcagcc cgggcgaaac cgtgaccctg       60

acctgccgca gcagcaccgg cgcggtgacc accagcaact atgcgagctg ggtgcaggaa      120

aaaccggatc atctgtttac cggcctgatt ggcggcacca acaaccgcgc gccgggcgtg      180

ccggcgcgct ttagcggcag cctgattggc gataaagcgg cgctgaccat taccggcgcg      240

cagaccgaag atgaagcgat ttatttttgc gtgctgtggt atagcgacca ttgggtgttt      300

ggctgcggca ccaaactgac cgtgctgggt ggaggcggtg gctcaggcgg aggtggctca      360

ggcggtggcg ggtctggcgg cggcggcagc gatgtgcagc tgcagcagag cggcccgggc      420

ctggtggcgc cgagccagag cctgagcatt acctgcaccg tgagcggctt tctcctgacc      480

gattatggcg tgaactgggt gcgccagagc ccgggcaaat gcctggaatg gctgggcgtg      540

atttggggcg atggcattac cgattataac agcgcgctga aaagccgcct gagcgtgacc      600

aaagataaca gcaaaagcca ggtgtttctg aaaatgaaca gcctgcagag cggcgatagc      660

gcgcgctatt attgcgtgac cggcctgttt gattattggg gccagggcac caccctgacc      720

gtgagcagcg cggccgccca tcaccatcac catcacgaac agaaactgat tagcgaagaa      780

gatctgtaat ag                                                          792


<210>  5
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FLEXIBLE PEPTIDE LINKER

<400>  5

Asp Lys Thr His Thr Cys Ala Ala 
1               5               


<210>  6
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FLEXIBLE PEPTIDE LINKER

<400>  6

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10      


<210>  7
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FLEXIBLE PEPTIDE LINKER

<400>  7

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Thr Cys Pro Pro Cys 
1               5                   10                  15      


Pro Ala 
        


<210>  8
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FLEXIBLE PEPTIDE LINKER

<400>  8

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Thr Cys Pro Pro Cys 
1               5                   10                  15      


Pro Ala Thr Cys Pro Pro Cys Pro Ala 
            20                  25  


<210>  9
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FLEXIBLE PEPTIDE LINKER

<400>  9

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Gly Lys Pro Thr Leu 
1               5                   10                  15      


Tyr Asn Ser Leu Val Met Ser Asp Thr Ala Gly Thr Cys Tyr 
            20                  25                  30  


<210>  10
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FLEXIBLE PEPTIDE LINKER

<400>  10

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Gly Lys Pro Thr His 
1               5                   10                  15      


Val Asn Val Ser Val Val Met Ala Glu Val Asp Gly Thr Cys Tyr 
            20                  25                  30      


<210>  11
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FLEXIBLE PEPTIDE LINKER

<400>  11

Asp Lys Thr His Thr Cys Cys Val Glu Cys Pro Pro Cys Pro Ala 
1               5                   10                  15  


<210>  12
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FLEXIBLE PEPTIDE LINKER

<400>  12

Asp Lys Thr His Thr Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp 
1               5                   10                  15      


Thr Pro Pro Pro Cys Pro Arg Cys Pro Ala 
            20                  25      


<210>  13
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FLEXIBLE PEPTIDE LINKER

<400>  13

Asp Lys Thr His Thr Cys Pro Ser Cys Pro Ala 
1               5                   10      


<210>  14
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker

<400>  14

Ser Gly Gly Gly Gly Ser Glu 
1               5           


<210>  15
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker

<400>  15

Asp Lys Thr His Thr Ser 
1               5       


<210>  16
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker

<400>  16

Ser Gly Gly Gly Gly Ser 
1               5       


<210>  17
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker

<400>  17

Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10      


<210>  18
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker

<400>  18

Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15      


<210>  19
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker

<400>  19

Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15      


Gly Gly Gly Gly Ser 
            20      


<210>  20
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker

<400>  20

Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15      


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            20                  25      


<210>  21
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker

<400>  21

Ala Ala Ala Gly Ser Gly Gly Ala Ser Ala Ser 
1               5                   10      


<210>  22
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker


<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa can be any naturally occurring amino acid

<400>  22

Ala Ala Ala Gly Ser Gly Xaa Gly Gly Gly Ser Gly Ala Ser Ala Ser 
1               5                   10                  15      


<210>  23
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker


<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  Xaa can be any naturally occurring amino acid

<400>  23

Ala Ala Ala Gly Ser Gly Xaa Gly Gly Gly Ser Xaa Gly Gly Gly Ser 
1               5                   10                  15      


Gly Ala Ser Ala Ser 
            20      


<210>  24
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker


<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  Xaa can be any naturally occurring amino acid

<400>  24

Ala Ala Ala Gly Ser Gly Xaa Gly Gly Gly Ser Xaa Gly Gly Gly Ser 
1               5                   10                  15      


Xaa Gly Gly Gly Ser Gly Ala Ser Ala Ser 
            20                  25      


<210>  25
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker


<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  Xaa can be any naturally occurring amino acid

<400>  25

Ala Ala Ala Gly Ser Gly Xaa Gly Gly Gly Ser Xaa Gly Gly Gly Ser 
1               5                   10                  15      


Xaa Gly Gly Gly Ser Xaa Gly Gly Gly Ser Gly Ala Ser Ala Ser 
            20                  25                  30      


<210>  26
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker


<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa can be any naturally occurring amino acid

<400>  26

Ala Ala Ala Gly Ser Gly Xaa Ser Gly Ala Ser Ala Ser 
1               5                   10              


<210>  27
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker

<400>  27

Pro Gly Gly Asn Arg Gly Thr Thr Thr Thr Arg Arg Pro Ala Thr Thr 
1               5                   10                  15      


Thr Gly Ser Ser Pro Gly Pro Thr Gln Ser His Tyr 
            20                  25              


<210>  28
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker

<400>  28

Ala Thr Thr Thr Gly Ser Ser Pro Gly Pro Thr 
1               5                   10      


<210>  29
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker

<400>  29

Ala Thr Thr Thr Gly Ser 
1               5       


<210>  30
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker

<400>  30

Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala 
1               5                   10              


<210>  31
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker

<400>  31

Glu Pro Ser Gly Pro Ile Ser Thr Ile Asn Ser Pro Pro Ser Lys Glu 
1               5                   10                  15      


Ser His Lys Ser Pro 
            20      


<210>  32
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>    Flexible linker

<400>  32

Gly Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
1               5                   10                  15  


<210>  33
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker

<400>  33

Gly Gly Gly Gly Ile Ala Pro Ser Met Val Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  34
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker

<400>  34

Gly Gly Gly Gly Lys Val Glu Gly Ala Gly Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  35
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker

<400>  35

Gly Gly Gly Gly Ser Met Lys Ser His Asp Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  36
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker

<400>  36

Gly Gly Gly Gly Asn Leu Ile Thr Ile Val Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  37
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker

<400>  37

Gly Gly Gly Gly Val Val Pro Ser Leu Pro Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  38
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker

<400>  38

Gly Gly Glu Lys Ser Ile Pro Gly Gly Gly Gly Ser 
1               5                   10          


<210>  39
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker

<400>  39

Arg Pro Leu Ser Tyr Arg Pro Pro Phe Pro Phe Gly Phe Pro Ser Val 
1               5                   10                  15      


Arg Pro 
        


<210>  40
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker

<400>  40

Tyr Pro Arg Ser Ile Tyr Ile Arg Arg Arg His Pro Ser Pro Ser Leu 
1               5                   10                  15      


Thr Thr 
        


<210>  41
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker

<400>  41

Thr Pro Ser His Leu Ser His Ile Leu Pro Ser Phe Gly Leu Pro Thr 
1               5                   10                  15      


Phe Asn 
        


<210>  42
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker

<400>  42

Arg Pro Val Ser Pro Phe Thr Phe Pro Arg Leu Ser Asn Ser Trp Leu 
1               5                   10                  15      


Pro Ala 
        


<210>  43
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker

<400>  43

Ser Pro Ala Ala His Phe Pro Arg Ser Ile Pro Arg Pro Gly Pro Ile 
1               5                   10                  15      


Arg Thr 
        


<210>  44
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker

<400>  44

Ala Pro Gly Pro Ser Ala Pro Ser His Arg Ser Leu Pro Ser Arg Ala 
1               5                   10                  15      


Phe Gly 
        


<210>  45
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker

<400>  45

Pro Arg Asn Ser Ile His Phe Leu His Pro Leu Leu Val Ala Pro Leu 
1               5                   10                  15      


Gly Ala 
        


<210>  46
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker

<400>  46

Met Pro Ser Leu Ser Gly Val Leu Gln Val Arg Tyr Leu Ser Pro Pro 
1               5                   10                  15      


Asp Leu 
        


<210>  47
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker

<400>  47

Ser Pro Gln Tyr Pro Ser Pro Leu Thr Leu Thr Leu Pro Pro His Pro 
1               5                   10                  15      


Ser Leu 
        


<210>  48
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker

<400>  48

Asn Pro Ser Leu Asn Pro Pro Ser Tyr Leu His Arg Ala Pro Ser Arg 
1               5                   10                  15      


Ile Ser 
        


<210>  49
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker

<400>  49

Leu Pro Trp Arg Thr Ser Leu Leu Pro Ser Leu Pro Leu Arg Arg Arg 
1               5                   10                  15      


Pro 
    


<210>  50
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker

<400>  50

Pro Pro Leu Phe Ala Lys Gly Pro Val Gly Leu Leu Ser Arg Ser Phe 
1               5                   10                  15      


Pro Pro 
        


<210>  51
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker

<400>  51

Val Pro Pro Ala Pro Val Val Ser Leu Arg Ser Ala His Ala Arg Pro 
1               5                   10                  15      


Pro Tyr 
        


<210>  52
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker

<400>  52

Leu Arg Pro Thr Pro Pro Arg Val Arg Ser Tyr Thr Cys Cys Pro Thr 
1               5                   10                  15      


Pro 
    


<210>  53
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker

<400>  53

Pro Asn Val Ala His Val Leu Pro Leu Leu Thr Val Pro Trp Asp Asn 
1               5                   10                  15      


Leu Arg 
        


<210>  54
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker

<400>  54

Cys Asn Pro Leu Leu Pro Leu Cys Ala Arg Ser Pro Ala Val Arg Thr 
1               5                   10                  15      


Phe Pro 
        


<210>  55
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  55

Asp Leu Cys Leu Arg Asp Trp Gly Cys Leu Trp 
1               5                   10      


<210>  56
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  56

Asp Ile Cys Leu Pro Arg Trp Gly Cys Leu Trp 
1               5                   10      


<210>  57
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  57

Met Glu Asp Ile Cys Leu Pro Arg Trp Gly Cys Leu Trp Gly Asp 
1               5                   10                  15  


<210>  58
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  58

Gln Arg Leu Met Glu Asp Ile Cys Leu Pro Arg Trp Gly Cys Leu Trp 
1               5                   10                  15      


Glu Asp Asp Glu 
            20  


<210>  59
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  59

Gln Gly Leu Ile Gly Asp Ile Cys Leu Pro Arg Trp Gly Cys Leu Trp 
1               5                   10                  15      


Gly Arg Ser Val 
            20  


<210>  60
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  60

Gln Gly Leu Ile Gly Asp Ile Cys Leu Pro Arg Trp Gly Cys Leu Trp 
1               5                   10                  15      


Gly Arg Ser Val Lys 
            20      


<210>  61
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  61

Glu Asp Ile Cys Leu Pro Arg Trp Gly Cys Leu Trp Glu Asp Asp 
1               5                   10                  15  


<210>  62
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  62

Arg Leu Met Glu Asp Ile Cys Leu Pro Arg Trp Gly Cys Leu Trp Glu 
1               5                   10                  15      


Asp Asp 
        


<210>  63
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  63

Met Glu Asp Ile Cys Leu Pro Arg Trp Gly Cys Leu Trp Glu Asp Asp 
1               5                   10                  15      


<210>  64
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  64

Met Glu Asp Ile Cys Leu Pro Arg Trp Gly Cys Leu Trp Glu Asp 
1               5                   10                  15  


<210>  65
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  65

Arg Leu Met Glu Asp Ile Cys Leu Ala Arg Trp Gly Cys Leu Trp Glu 
1               5                   10                  15      


Asp Asp 
        


<210>  66
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  66

Glu Val Arg Ser Phe Cys Thr Arg Trp Pro Ala Glu Lys Ser Cys Lys 
1               5                   10                  15      


Pro Leu Arg Gly 
            20  


<210>  67
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  67

Arg Ala Pro Glu Ser Phe Val Cys Tyr Trp Glu Thr Ile Cys Phe Glu 
1               5                   10                  15      


Arg Ser Glu Gln 
            20  


<210>  68
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  68

Glu Met Cys Tyr Phe Pro Gly Ile Cys Trp Met 
1               5                   10      


<210>  69
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide sequence

<400>  69

Gly Ala Pro Ala Pro Ala Ala Pro Ala Pro Ala 
1               5                   10      


<210>  70
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide sequence

<400>  70

Pro Pro Pro Pro 
1               


<210>  71
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Linker

<400>  71

Ala Ser Gly Gly Gly Gly 
1               5       


<210>  72
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  72

Ala Ser Gly Gly Gly Gly Ser Gly 
1               5               


<210>  73
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  73

Ala Ser Gly Gly Gly 
1               5   


<210>  74
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  74

Ala Ala Ala Ser Gly Gly Gly 
1               5           


<210>  75
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GCN4 peptide variant

<400>  75

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Tyr His Leu Glu Asn Glu Val Ala Arg Leu Lys Lys 
            20                  25                  30          


Leu Val Gly Glu Arg His His His His His His 
        35                  40              


<210>  76
<211>  43
<212>  PRT
<213>  artificial sequence

<220>
<223>  GCN4 peptide variant

<400>  76

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Tyr His Leu Glu Asn Glu Val Ala Arg Leu Lys Ala 
            20                  25                  30          


Leu Val Gly Glu Arg His His His His His His 
        35                  40              


<210>  77
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GCN4 peptide variant

<400>  77

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Tyr His Leu Glu Asn Glu Val Ala Arg Leu Ala Lys 
            20                  25                  30          


Leu Val Gly Glu Arg His His His His His His 
        35                  40              


<210>  78
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GCN4 peptide variant

<400>  78

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Tyr His Leu Glu Asn Glu Val Ala Arg Leu Gln Lys 
            20                  25                  30          


Leu Val Gly Glu Arg His His His His His His 
        35                  40              


<210>  79
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GCN4 peptide variant

<400>  79

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Tyr His Leu Glu Asn Glu Val Ala Arg Leu Asn Lys 
            20                  25                  30          


Leu Val Gly Glu Arg His His His His His His 
        35                  40              


<210>  80
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GCN4 peptide variant

<400>  80

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Tyr His Leu Glu Asn Glu Val Ala Arg Leu Ala Ala 
            20                  25                  30          


Leu Val Gly Glu Arg His His His His His His 
        35                  40              


<210>  81
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GCN4 peptide variant

<400>  81

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Tyr His Leu Glu Asn Glu Val Ala Arg Leu Gln Ala 
            20                  25                  30          


Leu Val Gly Glu Arg His His His His His His 
        35                  40              


<210>  82
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GCN4 peptide variant

<400>  82

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Tyr His Leu Glu Asn Glu Val Ala Arg Leu Asn Ala 
            20                  25                  30          


Leu Val Gly Glu Arg His His His His His His 
        35                  40              


<210>  83
<211>  44
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GCN4 peptide variant

<400>  83

Ala Ser Gly Gly Gly Ala Met Lys Gln Leu Glu Pro Lys Val Glu Glu 
1               5                   10                  15      


Leu Leu Pro Lys Asn Tyr His Leu Glu Asn Glu Val Ala Arg Leu Lys 
            20                  25                  30          


Lys Leu Val Gly Glu Arg His His His His His His 
        35                  40                  


<210>  84
<211>  44
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GCN4 peptide variant

<400>  84

Ala Ser Gly Gly Gly Arg Met Lys Gln Leu Glu Pro Lys Val Glu Glu 
1               5                   10                  15      


Leu Leu Pro Lys Asn Tyr His Leu Glu Asn Glu Val Ala Arg Leu Lys 
            20                  25                  30          


Ala Leu Val Gly Glu Arg His His His His His His 
        35                  40                  


<210>  85
<211>  44
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GCN4 peptide variant

<400>  85

Ala Ser Gly Gly Gly Ala Met Lys Gln Leu Glu Pro Lys Val Glu Glu 
1               5                   10                  15      


Leu Leu Pro Lys Asn Tyr His Leu Glu Asn Glu Val Ala Arg Leu Lys 
            20                  25                  30          


Ala Leu Val Gly Glu Arg His His His His His His 
        35                  40                  


<210>  86
<211>  44
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GCN4 peptide variant

<400>  86

Ala Ser Gly Gly Gly Arg Met Lys Gln Leu Glu Pro Lys Val Glu Glu 
1               5                   10                  15      


Leu Leu Pro Lys Asn Tyr His Leu Glu Asn Glu Val Ala Arg Leu Ala 
            20                  25                  30          


Lys Leu Val Gly Glu Arg His His His His His His 
        35                  40                  


<210>  87
<211>  44
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GCN4 peptide variant

<400>  87

Ala Ser Gly Gly Gly Arg Met Lys Gln Leu Glu Pro Lys Val Glu Glu 
1               5                   10                  15      


Leu Leu Pro Lys Asn Tyr His Leu Glu Asn Glu Val Ala Arg Leu Gln 
            20                  25                  30          


Lys Leu Val Gly Glu Arg His His His His His His 
        35                  40                  


<210>  88
<211>  44
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GCN4 peptide variant

<400>  88

Ala Ser Gly Gly Gly Arg Met Lys Gln Leu Glu Pro Lys Val Glu Glu 
1               5                   10                  15      


Leu Leu Pro Lys Asn Tyr His Leu Glu Asn Glu Val Ala Arg Leu Asn 
            20                  25                  30          


Lys Leu Val Gly Glu Arg His His His His His His 
        35                  40                  


<210>  89
<211>  44
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GCN4 peptide variant

<400>  89

Ala Ser Gly Gly Gly Ala Met Lys Gln Leu Glu Pro Lys Val Glu Glu 
1               5                   10                  15      


Leu Leu Pro Lys Asn Tyr His Leu Glu Asn Glu Val Ala Arg Leu Ala 
            20                  25                  30          


Lys Leu Val Gly Glu Arg His His His His His His 
        35                  40                  


<210>  90
<211>  44
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GCN4 peptide variant

<400>  90

Ala Ser Gly Gly Gly Ala Met Lys Gln Leu Glu Pro Lys Val Glu Glu 
1               5                   10                  15      


Leu Leu Pro Lys Asn Tyr His Leu Glu Asn Glu Val Ala Arg Leu Gln 
            20                  25                  30          


Lys Leu Val Gly Glu Arg His His His His His His 
        35                  40                  


<210>  91
<211>  44
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GCN4 peptide variant

<400>  91

Ala Ser Gly Gly Gly Ala Met Lys Gln Leu Glu Pro Lys Val Glu Glu 
1               5                   10                  15      


Leu Leu Pro Lys Asn Tyr His Leu Glu Asn Glu Val Ala Arg Leu Asn 
            20                  25                  30          


Lys Leu Val Gly Glu Arg His His His His His His 
        35                  40                  


<210>  92
<211>  44
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GCN4 peptide variant

<400>  92

Ala Ser Gly Gly Gly Arg Met Lys Gln Leu Glu Pro Lys Val Glu Glu 
1               5                   10                  15      


Leu Leu Pro Lys Asn Tyr His Leu Glu Asn Glu Val Ala Arg Leu Ala 
            20                  25                  30          


Ala Leu Val Gly Glu Arg His His His His His His 
        35                  40                  


<210>  93
<211>  44
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GCN4 peptide variant

<400>  93

Ala Ser Gly Gly Gly Arg Met Lys Gln Leu Glu Pro Lys Val Glu Glu 
1               5                   10                  15      


Leu Leu Pro Lys Asn Tyr His Leu Glu Asn Glu Val Ala Arg Leu Gln 
            20                  25                  30          


Ala Leu Val Gly Glu Arg His His His His His His 
        35                  40                  


<210>  94
<211>  44
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GCN4 peptide variant

<400>  94

Ala Ser Gly Gly Gly Arg Met Lys Gln Leu Glu Pro Lys Val Glu Glu 
1               5                   10                  15      


Leu Leu Pro Lys Asn Tyr His Leu Glu Asn Glu Val Ala Arg Leu Asn 
            20                  25                  30          


Ala Leu Val Gly Glu Arg His His His His His His 
        35                  40                  


<210>  95
<211>  44
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GCN4 peptide variant

<400>  95

Ala Ser Gly Gly Gly Ala Met Lys Gln Leu Glu Pro Lys Val Glu Glu 
1               5                   10                  15      


Leu Leu Pro Lys Asn Tyr His Leu Glu Asn Glu Val Ala Arg Leu Ala 
            20                  25                  30          


Ala Leu Val Gly Glu Arg His His His His His His 
        35                  40                  


<210>  96
<211>  44
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GCN4 peptide variant

<400>  96

Ala Ser Gly Gly Gly Ala Met Lys Gln Leu Glu Pro Lys Val Glu Glu 
1               5                   10                  15      


Leu Leu Pro Lys Asn Tyr His Leu Glu Asn Glu Val Ala Arg Leu Gln 
            20                  25                  30          


Ala Leu Val Gly Glu Arg His His His His His His 
        35                  40                  


<210>  97
<211>  44
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GCN4 peptide variant

<400>  97

Ala Ser Gly Gly Gly Ala Met Lys Gln Leu Glu Pro Lys Val Glu Glu 
1               5                   10                  15      


Leu Leu Pro Lys Asn Tyr His Leu Glu Asn Glu Val Ala Arg Leu Asn 
            20                  25                  30          


Ala Leu Val Gly Glu Arg His His His His His His 
        35                  40                  


<210>  98
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  52SR4 scFV variant

<400>  98

Asp Ala Val Val Thr Gln Glu Ser Ala Leu Thr Ser Ser Pro Gly Glu 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Ser Trp Val Gln Glu Lys Pro Asp His Leu Phe Thr Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Ile Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Thr Glu Asp Glu Ala Ile Tyr Phe Cys Val Leu Trp Tyr Ser Asp 
                85                  90                  95      


His Trp Val Phe Gly Cys Gly Thr Lys Leu Thr Val Leu Gly Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Asp Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Ala Pro 
    130                 135                 140                 


Ser Gln Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Leu Leu Thr 
145                 150                 155                 160 


Asp Tyr Gly Val Asn Trp Val Arg Gln Ser Pro Gly Lys Cys Leu Glu 
                165                 170                 175     


Trp Leu Gly Val Ile Trp Gly Asp Gly Ile Thr Asp Tyr Asn Ser Ala 
            180                 185                 190         


Leu Lys Ser Arg Leu Ser Val Thr Lys Asp Asn Ser Lys Ser Gln Val 
        195                 200                 205             


Phe Leu Lys Met Asn Ser Leu Gln Ser Gly Asp Ser Ala Arg Tyr Tyr 
    210                 215                 220                 


Cys Val Thr Gly Leu Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr 
225                 230                 235                 240 


Val Ser Ser 
            


<210>  99
<211>  292
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  52SR4 scFv variant

<400>  99

Asp Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Leu Leu Thr Asp Tyr 
            20                  25                  30          


Gly Val Asn Trp Val Arg Gln Ser Pro Gly Lys Cys Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Gly Asp Gly Ile Thr Asp Tyr Asn Ser Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Ser Val Thr Lys Asp Asn Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Ser Gly Asp Ser Ala Arg Tyr Tyr Cys Val 
                85                  90                  95      


Thr Gly Leu Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser 
            100                 105                 110         


Ser Pro Ala Arg Phe Ser Gly Ser Leu Ile Gly Asp Lys Ala Ala Leu 
        115                 120                 125             


Thr Ile Thr Gly Ala Gln Thr Glu Asp Glu Ala Ile Tyr Phe Cys Val 
    130                 135                 140                 


Leu Trp Tyr Ser Asp His Trp Val Phe Gly Cys Gly Thr Lys Leu Thr 
145                 150                 155                 160 


Val Leu Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
                165                 170                 175     


Gly Ser Gly Gly Gly Gly Ser Asp Ala Val Val Thr Gln Glu Ser Ala 
            180                 185                 190         


Leu Thr Ser Ser Pro Gly Glu Thr Val Thr Leu Thr Cys Arg Ser Ser 
        195                 200                 205             


Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Ser Trp Val Gln Glu Lys 
    210                 215                 220                 


Pro Asp His Leu Phe Thr Gly Leu Ile Gly Gly Thr Asn Asn Arg Ala 
225                 230                 235                 240 


Pro Gly Val Pro Ala Arg Phe Ser Gly Ser Leu Ile Gly Asp Lys Ala 
                245                 250                 255     


Ala Leu Thr Ile Thr Gly Ala Gln Thr Glu Asp Glu Ala Ile Tyr Phe 
            260                 265                 270         


Cys Val Leu Trp Tyr Ser Asp His Trp Val Phe Gly Cys Gly Thr Lys 
        275                 280                 285             


Leu Thr Val Leu 
    290         


<210>  100
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  signal sequence

<400>  100

Met Ser Val Pro Thr Gln Val Leu Gly Leu Leu Leu Leu Trp Leu Thr 
1               5                   10                  15      


Asp Ala Arg Cys 
            20  


<210>  101
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  signal sequence

<400>  101

Met Glu Trp Ser Trp Val Phe Leu Phe Phe Leu Ser Val Thr Thr Gly 
1               5                   10                  15      


Val His Ser 
            


<210>  102
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  signal sequence

<400>  102

Met Asp Trp Leu Trp Thr Leu Leu Phe Leu Met Ala Ala Ala Gln Ser 
1               5                   10                  15      


Ala Gln Ala 
            


<210>  103
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  signal sequence

<400>  103

Met Gly Trp Ser Trp Thr Phe Leu Phe Leu Leu Ser Gly Thr Ser Gly 
1               5                   10                  15      


Val Leu Ser 
            


