                         SEQUENCE LISTING

<110>  GENETHON et al.
 
<120>  COMPOSITIONS AND METHODS FOR IMPROVING VIRAL VECTOR EFFICIENCY

<130>  B2148PC00

<160>  101   

<170>  PatentIn version 3.3

<210>  1
<211>  11
<212>  PRT
<213>  artificial

<220>
<223>  Tat (47-57)

<400>  1

Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg 
1               5                   10      


<210>  2
<211>  13
<212>  PRT
<213>  artificial

<220>
<223>  Tat (48-60)

<400>  2

Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Pro Pro Gln 
1               5                   10              


<210>  3
<211>  9
<212>  PRT
<213>  artificial

<220>
<223>  Tat (49-57)

<400>  3

Arg Lys Lys Arg Arg Gln Arg Arg Arg 
1               5                   


<210>  4
<211>  17
<212>  PRT
<213>  artificial

<220>
<223>  MAP peptide

<400>  4

Lys Leu Ala Leu Lys Leu Ala Leu Lys Ala Leu Lys Ala Ala Leu Lys 
1               5                   10                  15      


Ala 
    


<210>  5
<211>  18
<212>  PRT
<213>  artificial

<220>
<223>  MAP peptide

<400>  5

Lys Leu Ala Leu Lys Leu Ala Leu Lys Ala Leu Lys Ala Ala Leu Lys 
1               5                   10                  15      


Leu Ala 
        


<210>  6
<211>  16
<212>  PRT
<213>  artificial

<220>
<223>  Antennapedia (or penetratin)

<400>  6

Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys 
1               5                   10                  15      


<210>  7
<211>  7
<212>  PRT
<213>  artificial

<220>
<223>  Penetratin derivative

<400>  7

Arg Arg Met Lys Trp Lys Lys 
1               5           


<210>  8
<211>  8
<212>  PRT
<213>  artificial

<220>
<223>  Penetratin derivative

<400>  8

Asn Arg Arg Met Lys Trp Lys Lys 
1               5               


<210>  9
<211>  9
<212>  PRT
<213>  artificial

<220>
<223>  Penetratin derivative

<400>  9

Gln Asn Arg Arg Met Lys Trp Lys Lys 
1               5                   


<210>  10
<211>  10
<212>  PRT
<213>  artificial

<220>
<223>  Penetratin derivative

<400>  10

Phe Gln Asn Arg Arg Met Lys Trp Lys Lys 
1               5                   10  


<210>  11
<211>  7
<212>  PRT
<213>  artificial

<220>
<223>  Penetratin derivative

<400>  11

Arg Arg Glu Lys Trp Lys Lys 
1               5           


<210>  12
<211>  7
<212>  PRT
<213>  artificial

<220>
<223>  Penetratin derivative

<400>  12

Arg Arg Gln Lys Trp Lys Lys 
1               5           


<210>  13
<211>  7
<212>  PRT
<213>  artificial

<220>
<223>  Penetratin derivative

<400>  13

Lys Arg Met Lys Trp Lys Lys 
1               5           


<210>  14
<211>  7
<212>  PRT
<213>  artificial

<220>
<223>  Penetratin derivative

<400>  14

Arg Lys Met Lys Trp Lys Lys 
1               5           


<210>  15
<211>  7
<212>  PRT
<213>  artificial

<220>
<223>  Penetratin derivative


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa=Orn

<400>  15

Arg Arg Xaa Lys Trp Lys Lys 
1               5           


<210>  16
<211>  7
<212>  PRT
<213>  artificial

<220>
<223>  Penetratin derivative

<400>  16

Arg Arg Met Lys Gln Lys Lys 
1               5           


<210>  17
<211>  7
<212>  PRT
<213>  artificial

<220>
<223>  Penetratin derivative

<400>  17

Arg Arg Met Lys Trp Phe Lys 
1               5           


<210>  18
<211>  7
<212>  PRT
<213>  artificial

<220>
<223>  Penetratin derivative


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa=Orn

<400>  18

Arg Xaa Arg Lys Trp Lys Lys 
1               5           


<210>  19
<211>  7
<212>  PRT
<213>  artificial

<220>
<223>  Penetratin derivative

<400>  19

Arg Arg Met Trp Lys Lys Lys 
1               5           


<210>  20
<211>  7
<212>  PRT
<213>  artificial

<220>
<223>  Penetratin derivative

<400>  20

Arg Arg Met Lys Lys Trp Lys 
1               5           


<210>  21
<211>  16
<212>  PRT
<213>  artificial

<220>
<223>  D-penetratin


<220>
<221>  MISC_FEATURE
<222>  (1)..(16)
<223>  D-amino acid

<400>  21

Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys 
1               5                   10                  15      


<210>  22
<211>  18
<212>  PRT
<213>  artificial

<220>
<223>  Pegelin (SynB)

<400>  22

Arg Gly Gly Arg Leu Ser Tyr Ser Arg Arg Arg Phe Ser Thr Ser Thr 
1               5                   10                  15      


Gly Arg 
        


<210>  23
<211>  33
<212>  PRT
<213>  artificial

<220>
<223>  VP22

<400>  23

Asp Ala Ala Thr Ala Thr Arg Gly Arg Ser Ala Ala Ser Arg Pro Thr 
1               5                   10                  15      


Glu Arg Pro Arg Ala Pro Ala Arg Ser Ala Ser Arg Pro Arg Arg Val 
            20                  25                  30          


Asp 
    


<210>  24
<211>  27
<212>  PRT
<213>  artificial

<220>
<223>  Transportan

<400>  24

Gly Trp Thr Leu Asn Ser Ala Gly Tyr Leu Leu Gly Lys Ile Asn Leu 
1               5                   10                  15      


Lys Ala Leu Ala Ala Leu Ala Lys Lys Ile Leu 
            20                  25          


<210>  25
<211>  21
<212>  PRT
<213>  artificial

<220>
<223>  Transportan-10

<400>  25

Ala Gly Tyr Leu Leu Gly Lys Ile Asn Leu Lys Ala Leu Ala Ala Leu 
1               5                   10                  15      


Ala Lys Lys Ile Leu 
            20      


<210>  26
<211>  30
<212>  PRT
<213>  artificial

<220>
<223>  KALA

<400>  26

Trp Glu Ala Lys Leu Ala Lys Ala Leu Ala Lys Ala Leu Ala Lys His 
1               5                   10                  15      


Leu Ala Lys Ala Leu Ala Lys Ala Leu Lys Ala Cys Glu Ala 
            20                  25                  30  


<210>  27
<211>  21
<212>  PRT
<213>  artificial

<220>
<223>  Pep-1

<400>  27

Lys Glu Thr Trp Trp Glu Thr Trp Trp Thr Glu Trp Ser Gln Pro Lys 
1               5                   10                  15      


Lys Lys Arg Lys Val 
            20      


<210>  28
<211>  21
<212>  PRT
<213>  artificial

<220>
<223>  Pep-2

<400>  28

Lys Glu Thr Trp Phe Glu Thr Trp Phe Thr Glu Trp Ser Gln Pro Lys 
1               5                   10                  15      


Lys Lys Arg Lys Val 
            20      


<210>  29
<211>  27
<212>  PRT
<213>  artificial

<220>
<223>  MPG

<400>  29

Gly Ala Leu Phe Leu Gly Phe Leu Gly Ala Ala Gly Ser Thr Met Gly 
1               5                   10                  15      


Ala Trp Ser Gln Pro Lys Ser Lys Arg Lys Val 
            20                  25          


<210>  30
<211>  19
<212>  PRT
<213>  artificial

<220>
<223>  Vectocell peptide

<400>  30

Val Lys Arg Gly Leu Lys Leu Arg His Val Arg Pro Arg Val Thr Arg 
1               5                   10                  15      


Met Asp Val 
            


<210>  31
<211>  14
<212>  PRT
<213>  artificial

<220>
<223>  Vectocell peptide

<400>  31

Ser Arg Arg Ala Arg Arg Ser Pro Arg His Leu Gly Ser Gly 
1               5                   10                  


<210>  32
<211>  16
<212>  PRT
<213>  artificial

<220>
<223>  Vectocell peptide

<400>  32

Leu Arg Arg Glu Arg Gln Ser Arg Leu Arg Arg Glu Arg Gln Ser Arg 
1               5                   10                  15      


<210>  33
<211>  22
<212>  PRT
<213>  artificial

<220>
<223>  Vectocell peptide

<400>  33

Gly Ala Tyr Asp Leu Arg Arg Arg Glu Arg Gln Ser Arg Leu Arg Arg 
1               5                   10                  15      


Arg Glu Arg Gln Ser Arg 
            20          


<210>  34
<211>  29
<212>  PRT
<213>  artificial

<220>
<223>  Wr-T transporter


<220>
<221>  MISC_FEATURE
<222>  (22)..(29)
<223>  D-amino acids

<400>  34

Lys Glu Thr Trp Trp Glu Thr Trp Trp Thr Glu Trp Trp Thr Glu Trp 
1               5                   10                  15      


Ser Gln Gly Pro Gly Arg Arg Arg Arg Arg Arg Arg Arg 
            20                  25                  


<210>  35
<211>  7
<212>  PRT
<213>  artificial

<220>
<223>  R7

<400>  35

Arg Arg Arg Arg Arg Arg Arg 
1               5           


<210>  36
<211>  26
<212>  PRT
<213>  artificial

<220>
<223>  LAH4

<400>  36

Lys Lys Ala Leu Leu Ala Leu Ala Leu His His Leu Ala His Leu Ala 
1               5                   10                  15      


Leu His Leu Ala Leu Ala Leu Lys Lys Ala 
            20                  25      


<210>  37
<211>  26
<212>  PRT
<213>  artificial

<220>
<223>  LAH4 derivative

<400>  37

Lys Lys Ala Leu Leu Ala His Ala Leu His Leu Leu Ala Leu Leu Ala 
1               5                   10                  15      


Leu His Leu Ala His Ala Leu Lys Lys Ala 
            20                  25      


<210>  38
<211>  24
<212>  PRT
<213>  artificial

<220>
<223>  LAH4 derivative

<400>  38

Lys Lys Ala Leu Leu Ala His Ala Leu His Leu Leu Ala Leu Leu Ala 
1               5                   10                  15      


Leu His Leu Ala His Ala Leu Ala 
            20                  


<210>  39
<211>  26
<212>  PRT
<213>  artificial

<220>
<223>  LAH4 derivative

<400>  39

Arg Arg Ala Leu Leu Ala His Ala Leu His Leu Leu Ala Leu Leu Ala 
1               5                   10                  15      


Leu His Leu Ala His Ala Leu Arg Arg Ala 
            20                  25      


<210>  40
<211>  26
<212>  PRT
<213>  artificial

<220>
<223>  LAH4 derivative

<400>  40

Lys Lys Ala Leu Leu Ala His Ala Leu Ala His Leu Ala Leu Leu Ala 
1               5                   10                  15      


Leu His Leu Ala Leu His Leu Lys Lys Ala 
            20                  25      


<210>  41
<211>  26
<212>  PRT
<213>  artificial

<220>
<223>  LAH4 derivative

<400>  41

Lys Lys Ala Leu Leu Ala Leu Ala Leu His His Leu Ala Leu Leu Ala 
1               5                   10                  15      


Leu His Leu Ala His Ala Leu Lys Lys Ala 
            20                  25      


<210>  42
<211>  26
<212>  PRT
<213>  artificial

<220>
<223>  LAH4 derivative

<400>  42

Lys Lys Ala Leu Leu Ala Leu Ala Leu His His Leu Ala Leu Leu Ala 
1               5                   10                  15      


His His Leu Ala Leu Ala Leu Lys Lys Ala 
            20                  25      


<210>  43
<211>  26
<212>  PRT
<213>  artificial

<220>
<223>  LAH4 derivative

<400>  43

Lys Lys Ala Leu Leu His Leu Ala Leu Leu His Ala Ala Leu Leu Ala 
1               5                   10                  15      


His His Leu Ala Leu Ala Leu Lys Lys Ala 
            20                  25      


<210>  44
<211>  26
<212>  PRT
<213>  artificial

<220>
<223>  LAH4 derivative

<400>  44

Lys Lys Ala Leu Leu His Leu Ala Leu Leu His Ala Ala Leu Leu Ala 
1               5                   10                  15      


His Leu Ala Ala Leu His Leu Lys Lys Ala 
            20                  25      


<210>  45
<211>  26
<212>  PRT
<213>  artificial

<220>
<223>  LAH4 derivative

<400>  45

Lys Lys Ala Leu Leu His Leu Ala Leu Leu Leu Ala Ala Leu His Ala 
1               5                   10                  15      


His Leu Ala Ala Leu His Leu Lys Lys Ala 
            20                  25      


<210>  46
<211>  26
<212>  PRT
<213>  artificial

<220>
<223>  LAH4 derivative

<400>  46

Lys Lys Ala Leu Leu Ala His Ala Leu His Leu Leu Ala Ala Leu Ala 
1               5                   10                  15      


Leu His Leu Ala His Leu Leu Lys Lys Ala 
            20                  25      


<210>  47
<211>  26
<212>  PRT
<213>  artificial

<220>
<223>  LAH4 derivative

<400>  47

Lys Lys Ala Leu Leu Leu Ala Ala Leu His His Leu Ala Ala Leu Ala 
1               5                   10                  15      


Leu His Leu Ala His Leu Leu Lys Lys Ala 
            20                  25      


<210>  48
<211>  26
<212>  PRT
<213>  artificial

<220>
<223>  LAH4 derivative

<400>  48

Lys Lys Ala Leu Leu Leu Ala Ala Leu His His Leu Leu Ala Leu Ala 
1               5                   10                  15      


His His Leu Ala Ala Leu Leu Lys Lys Ala 
            20                  25      


<210>  49
<211>  26
<212>  PRT
<213>  artificial

<220>
<223>  LAH4 derivative

<400>  49

Lys Lys Ala Leu Leu His Ala Ala Leu Ala His Leu Leu Ala Leu Ala 
1               5                   10                  15      


His His Leu Leu Ala Leu Leu Lys Lys Ala 
            20                  25      


<210>  50
<211>  26
<212>  PRT
<213>  artificial

<220>
<223>  LAH4 derivative

<400>  50

Lys Lys Ala Leu Leu His Ala Leu Leu Ala His Leu Ala Ala Leu Leu 
1               5                   10                  15      


His Ala Leu Leu Ala His Leu Lys Lys Ala 
            20                  25      


<210>  51
<211>  26
<212>  PRT
<213>  artificial

<220>
<223>  LAH4 derivative

<400>  51

Lys Lys Ala Leu Leu His Ala Leu Leu Ala Ala Leu Leu Ala His Leu 
1               5                   10                  15      


His Ala Leu Leu Ala His Leu Lys Lys Ala 
            20                  25      


<210>  52
<211>  25
<212>  PRT
<213>  artificial

<220>
<223>  LAH4 derivative

<400>  52

Lys Ala Leu Leu His Ala Ala Leu Ala His Leu Leu Ala Leu Ala His 
1               5                   10                  15      


His Leu Leu Ala Leu Leu Lys Lys Ala 
            20                  25  


<210>  53
<211>  26
<212>  PRT
<213>  artificial

<220>
<223>  LAH4 derivative

<400>  53

Lys Lys Lys Leu Leu His Ala Ala Leu Ala His Leu Leu Ala Leu Ala 
1               5                   10                  15      


His His Leu Leu Ala Leu Leu Lys Lys Ala 
            20                  25      


<210>  54
<211>  24
<212>  PRT
<213>  artificial

<220>
<223>  LAH4 derivative

<400>  54

Lys Lys Ala Leu Leu His Ala Ala Leu Ala His Leu Leu Ala Leu Ala 
1               5                   10                  15      


His His Leu Leu Ala Leu Leu Ala 
            20                  


<210>  55
<211>  25
<212>  PRT
<213>  artificial

<220>
<223>  LAH4 derivative

<400>  55

Lys Lys Ala Leu Leu His Ala Ala Leu Ala His Leu Leu Ala Leu Ala 
1               5                   10                  15      


His His Leu Leu Ala Leu Leu Lys Lys 
            20                  25  


<210>  56
<211>  24
<212>  PRT
<213>  artificial

<220>
<223>  LAH4 derivative

<400>  56

Lys Lys Leu Leu His Ala Ala Leu Ala His Leu Leu Ala Leu Ala His 
1               5                   10                  15      


His Leu Leu Ala Leu Leu Lys Lys 
            20                  


<210>  57
<211>  24
<212>  PRT
<213>  artificial

<220>
<223>  LAH4 derivative

<400>  57

Lys Lys Ala Leu Leu His Ala Ala Leu Ala His Leu Leu Ala Leu Ala 
1               5                   10                  15      


His His Leu Leu Ala Leu Lys Lys 
            20                  


<210>  58
<211>  23
<212>  PRT
<213>  artificial

<220>
<223>  LAH4 derivative

<400>  58

Lys Lys Leu His Ala Ala Leu Ala His Leu Leu Ala Leu Ala His His 
1               5                   10                  15      


Leu Leu Ala Leu Leu Lys Lys 
            20              


<210>  59
<211>  21
<212>  PRT
<213>  artificial

<220>
<223>  LAH4 derivative

<400>  59

Lys Lys Leu His Ala Ala Leu Ala His Leu Leu Ala Leu Ala His His 
1               5                   10                  15      


Leu Leu Ala Lys Lys 
            20      


<210>  60
<211>  26
<212>  PRT
<213>  artificial

<220>
<223>  LAH4 derivative

<400>  60

Lys Lys Ala Leu Leu His Ala Ala Leu Ala His Leu Leu Ala Leu Ala 
1               5                   10                  15      


Ala Ala Leu Leu Ala Leu Leu Lys Lys Ala 
            20                  25      


<210>  61
<211>  26
<212>  PRT
<213>  artificial

<220>
<223>  LAH4 derivative

<400>  61

Lys Lys Ala Leu Leu Ala Ala Ala Leu Ala Ala Leu Leu Ala Leu Ala 
1               5                   10                  15      


Ala Ala Leu Leu Ala Leu Leu Lys Lys Ala 
            20                  25      


<210>  62
<211>  26
<212>  PRT
<213>  artificial

<220>
<223>  LAH4 derivative

<400>  62

Lys Lys Leu Leu Leu His Ala Leu Leu Ala His Leu Leu Ala Leu Leu 
1               5                   10                  15      


His His Leu Leu Ala Leu Leu Lys Lys Leu 
            20                  25      


<210>  63
<211>  450
<212>  PRT
<213>  Homo sapiens

<400>  63

Met Glu Gly Ser Lys Thr Ser Asn Asn Ser Thr Met Gln Val Ser Phe 
1               5                   10                  15      


Val Cys Gln Arg Cys Ser Gln Pro Leu Lys Leu Asp Thr Ser Phe Lys 
            20                  25                  30          


Ile Leu Asp Arg Val Thr Ile Gln Glu Leu Thr Ala Pro Leu Leu Thr 
        35                  40                  45              


Thr Ala Gln Ala Lys Pro Gly Glu Thr Gln Glu Glu Glu Thr Asn Ser 
    50                  55                  60                  


Gly Glu Glu Pro Phe Ile Glu Thr Pro Arg Gln Asp Gly Val Ser Arg 
65                  70                  75                  80  


Arg Phe Ile Pro Pro Ala Arg Met Met Ser Thr Glu Ser Ala Asn Ser 
                85                  90                  95      


Phe Thr Leu Ile Gly Glu Ala Ser Asp Gly Gly Thr Met Glu Asn Leu 
            100                 105                 110         


Ser Arg Arg Leu Lys Val Thr Gly Asp Leu Phe Asp Ile Met Ser Gly 
        115                 120                 125             


Gln Thr Asp Val Asp His Pro Leu Cys Glu Glu Cys Thr Asp Thr Leu 
    130                 135                 140                 


Leu Asp Gln Leu Asp Thr Gln Leu Asn Val Thr Glu Asn Glu Cys Gln 
145                 150                 155                 160 


Asn Tyr Lys Arg Cys Leu Glu Ile Leu Glu Gln Met Asn Glu Asp Asp 
                165                 170                 175     


Ser Glu Gln Leu Gln Met Glu Leu Lys Glu Leu Ala Leu Glu Glu Glu 
            180                 185                 190         


Arg Leu Ile Gln Glu Leu Glu Asp Val Glu Lys Asn Arg Lys Ile Val 
        195                 200                 205             


Ala Glu Asn Leu Glu Lys Val Gln Ala Glu Ala Glu Arg Leu Asp Gln 
    210                 215                 220                 


Glu Glu Ala Gln Tyr Gln Arg Glu Tyr Ser Glu Phe Lys Arg Gln Gln 
225                 230                 235                 240 


Leu Glu Leu Asp Asp Glu Leu Lys Ser Val Glu Asn Gln Met Arg Tyr 
                245                 250                 255     


Ala Gln Thr Gln Leu Asp Lys Leu Lys Lys Thr Asn Val Phe Asn Ala 
            260                 265                 270         


Thr Phe His Ile Trp His Ser Gly Gln Phe Gly Thr Ile Asn Asn Phe 
        275                 280                 285             


Arg Leu Gly Arg Leu Pro Ser Val Pro Val Glu Trp Asn Glu Ile Asn 
    290                 295                 300                 


Ala Ala Trp Gly Gln Thr Val Leu Leu Leu His Ala Leu Ala Asn Lys 
305                 310                 315                 320 


Met Gly Leu Lys Phe Gln Arg Tyr Arg Leu Val Pro Tyr Gly Asn His 
                325                 330                 335     


Ser Tyr Leu Glu Ser Leu Thr Asp Lys Ser Lys Glu Leu Pro Leu Tyr 
            340                 345                 350         


Cys Ser Gly Gly Leu Arg Phe Phe Trp Asp Asn Lys Phe Asp His Ala 
        355                 360                 365             


Met Val Ala Phe Leu Asp Cys Val Gln Gln Phe Lys Glu Glu Val Glu 
    370                 375                 380                 


Lys Gly Glu Thr Arg Phe Cys Leu Pro Tyr Arg Met Asp Val Glu Lys 
385                 390                 395                 400 


Gly Lys Ile Glu Asp Thr Gly Gly Ser Gly Gly Ser Tyr Ser Ile Lys 
                405                 410                 415     


Thr Gln Phe Asn Ser Glu Glu Gln Trp Thr Lys Ala Leu Lys Phe Met 
            420                 425                 430         


Leu Thr Asn Leu Lys Trp Gly Leu Ala Trp Val Ser Ser Gln Phe Tyr 
        435                 440                 445             


Asn Lys 
    450 


<210>  64
<211>  431
<212>  PRT
<213>  Homo sapiens

<400>  64

Met Ser Ser Ile Arg Phe Leu Cys Gln Arg Cys His Gln Ala Leu Lys 
1               5                   10                  15      


Leu Ser Gly Ser Ser Glu Ser Arg Ser Leu Pro Ala Ala Pro Ala Pro 
            20                  25                  30          


Thr Ser Gly Gln Ala Glu Pro Gly Asp Thr Arg Glu Pro Gly Val Thr 
        35                  40                  45              


Thr Arg Glu Val Thr Asp Ala Glu Glu Gln Gln Asp Gly Ala Ser Ser 
    50                  55                  60                  


Arg Ser Pro Pro Gly Asp Gly Ser Val Ser Lys Gly His Ala Asn Ile 
65                  70                  75                  80  


Phe Thr Leu Leu Gly Glu Leu Gly Ala Met His Met Leu Ser Ser Ile 
                85                  90                  95      


Gln Lys Ala Ala Gly Asp Ile Phe Asp Ile Val Ser Gly Gln Ala Val 
            100                 105                 110         


Val Asp His Pro Leu Cys Glu Glu Cys Thr Asp Ser Leu Leu Glu Gln 
        115                 120                 125             


Leu Asp Ile Gln Leu Ala Leu Thr Glu Ala Asp Ser Gln Asn Tyr Gln 
    130                 135                 140                 


Arg Cys Leu Glu Thr Gly Glu Leu Ala Thr Ser Glu Asp Glu Ala Ala 
145                 150                 155                 160 


Ala Leu Arg Ala Glu Leu Arg Asp Leu Glu Leu Glu Glu Ala Arg Leu 
                165                 170                 175     


Val Gln Glu Leu Glu Asp Val Asp Arg Asn Asn Ala Arg Ala Ala Ala 
            180                 185                 190         


Asp Leu Gln Ala Ala Gln Ala Glu Ala Ala Glu Leu Asp Gln Gln Glu 
        195                 200                 205             


Arg Gln His Tyr Arg Asp Tyr Ser Ala Leu Lys Arg Gln Gln Leu Glu 
    210                 215                 220                 


Leu Leu Asp Gln Leu Gly Asn Val Glu Asn Gln Leu Gln Tyr Ala Arg 
225                 230                 235                 240 


Val Gln Arg Asp Arg Leu Lys Glu Ile Asn Cys Phe Thr Ala Thr Phe 
                245                 250                 255     


Glu Ile Trp Val Glu Gly Pro Leu Gly Val Ile Asn Asn Phe Arg Leu 
            260                 265                 270         


Gly Arg Leu Pro Thr Val Arg Val Gly Trp Asn Glu Ile Asn Thr Ala 
        275                 280                 285             


Trp Gly Gln Ala Ala Leu Leu Leu Leu Thr Leu Ala Asn Thr Ile Gly 
    290                 295                 300                 


Leu Gln Phe Gln Arg Tyr Arg Leu Ile Pro Cys Gly Asn His Ser Tyr 
305                 310                 315                 320 


Leu Lys Ser Leu Thr Asp Asp Arg Thr Glu Leu Pro Leu Phe Cys Tyr 
                325                 330                 335     


Gly Gly Gln Asp Val Phe Leu Asn Asn Lys Tyr Asp Arg Ala Met Val 
            340                 345                 350         


Ala Phe Leu Asp Cys Met Gln Gln Phe Lys Glu Glu Ala Glu Lys Gly 
        355                 360                 365             


Glu Leu Gly Leu Ser Leu Pro Tyr Gly Ile Gln Val Glu Thr Gly Leu 
    370                 375                 380                 


Met Glu Asp Val Gly Gly Arg Gly Glu Cys Tyr Ser Ile Arg Thr His 
385                 390                 395                 400 


Leu Asn Thr Gln Glu Leu Trp Thr Lys Ala Leu Lys Phe Met Leu Ile 
                405                 410                 415     


Asn Phe Lys Trp Ser Leu Ile Trp Val Ala Ser Arg Tyr Gln Lys 
            420                 425                 430     


<210>  65
<211>  18
<212>  PRT
<213>  artificial

<220>
<223>  beclin-1 267-284

<400>  65

Thr Asn Val Phe Asn Ala Thr Phe His Ile Trp His Ser Gly Gln Phe 
1               5                   10                  15      


Gly Thr 
        


<210>  66
<211>  18
<212>  PRT
<213>  artificial

<220>
<223>  modified beclin-1 267-284

<400>  66

Thr Asn Val Phe Asn Ala Thr Phe Glu Ile Trp His Asp Gly Glu Phe 
1               5                   10                  15      


Gly Thr 
        


<210>  67
<211>  15
<212>  PRT
<213>  artificial

<220>
<223>  modified beclin-1 270-284

<400>  67

Phe Asn Ala Thr Phe Glu Ile Trp His Asp Gly Glu Phe Gly Thr 
1               5                   10                  15  


<210>  68
<211>  16
<212>  PRT
<213>  artificial

<220>
<223>  modified beclin-1 267-282

<400>  68

Thr Asn Val Phe Asn Ala Thr Phe Glu Ile Trp His Asp Gly Glu Phe 
1               5                   10                  15      


<210>  69
<211>  29
<212>  PRT
<213>  artificial

<220>
<223>  modified beclin-1 256-284

<400>  69

Tyr Ala Gln Thr Gln Leu Asp Lys Leu Lys Lys Thr Asn Val Phe Asn 
1               5                   10                  15      


Ala Thr Phe Glu Ile Trp His Asp Gly Glu Phe Gly Thr 
            20                  25                  


<210>  70
<211>  30
<212>  PRT
<213>  artificial

<220>
<223>  modified beclin-1 267-296

<400>  70

Thr Asn Val Phe Asn Ala Thr Phe Glu Ile Trp His Asp Gly Glu Phe 
1               5                   10                  15      


Gly Thr Ile Asn Asn Phe Arg Leu Gly Arg Leu Pro Ser Val 
            20                  25                  30  


<210>  71
<211>  33
<212>  PRT
<213>  artificial

<220>
<223>  modified beclin-1 250-282

<400>  71

Val Glu Asn Gln Met Arg Tyr Ala Gln Thr Gln Leu Asp Lys Leu Lys 
1               5                   10                  15      


Lys Thr Asn Val Phe Asn Ala Thr Phe Glu Ile Trp His Asp Gly Glu 
            20                  25                  30          


Phe 
    


<210>  72
<211>  29
<212>  PRT
<213>  artificial

<220>
<223>  modified beclin-1 270-298

<400>  72

Phe Asn Ala Thr Phe Glu Ile Trp His Asp Gly Glu Phe Gly Thr Ile 
1               5                   10                  15      


Asn Asn Phe Arg Leu Gly Arg Leu Pro Ser Val Pro Val 
            20                  25                  


<210>  73
<211>  25
<212>  PRT
<213>  artificial

<220>
<223>  modified beclin-1 274-298

<400>  73

Phe Glu Ile Trp His Asp Gly Glu Phe Gly Thr Ile Asn Asn Phe Arg 
1               5                   10                  15      


Leu Gly Arg Leu Pro Ser Val Pro Val 
            20                  25  


<210>  74
<211>  41
<212>  PRT
<213>  artificial

<220>
<223>  modified Tat-Beclin-1 + beclin-1 285-296

<400>  74

Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Thr Asn Val Phe Asn 
1               5                   10                  15      


Ala Thr Phe Glu Ile Trp His Asp Gly Glu Phe Gly Thr Ile Asn Asn 
            20                  25                  30          


Phe Arg Leu Gly Arg Leu Pro Ser Val 
        35                  40      


<210>  75
<211>  31
<212>  PRT
<213>  artificial

<220>
<223>  TB1

<400>  75

Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Gly Gly Thr Asn Val 
1               5                   10                  15      


Phe Asn Ala Thr Phe Glu Ile Trp His Asp Gly Glu Phe Gly Thr 
            20                  25                  30      


<210>  76
<211>  36
<212>  PRT
<213>  artificial

<220>
<223>  MAP-B1

<400>  76

Lys Leu Ala Leu Lys Leu Ala Leu Lys Ala Leu Lys Ala Ala Leu Lys 
1               5                   10                  15      


Ala Gly Thr Asn Val Phe Asn Ala Thr Phe Glu Ile Trp His Asp Gly 
            20                  25                  30          


Glu Phe Gly Thr 
        35      


<210>  77
<211>  31
<212>  PRT
<213>  artificial

<220>
<223>  TB WT

<400>  77

Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Gly Gly Thr Asn Val 
1               5                   10                  15      


Phe Asn Ala Thr Phe His Ile Trp His Ser Gly Gln Phe Gly Thr 
            20                  25                  30      


<210>  78
<211>  42
<212>  PRT
<213>  artificial

<220>
<223>  TB1 256-284

<400>  78

Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Gly Gly Tyr Ala Gln 
1               5                   10                  15      


Thr Gln Leu Asp Lys Leu Lys Lys Thr Asn Val Phe Asn Ala Thr Phe 
            20                  25                  30          


Glu Ile Trp His Asp Gly Glu Phe Gly Thr 
        35                  40          


<210>  79
<211>  43
<212>  PRT
<213>  artificial

<220>
<223>  TB1 267-296

<400>  79

Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Gly Gly Thr Asn Val 
1               5                   10                  15      


Phe Asn Ala Thr Phe Glu Ile Trp His Asp Gly Glu Phe Gly Thr Ile 
            20                  25                  30          


Asn Asn Phe Arg Leu Gly Arg Leu Pro Ser Val 
        35                  40              


<210>  80
<211>  43
<212>  PRT
<213>  artificial

<220>
<223>  TB WT 267-296

<400>  80

Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Gly Gly Thr Asn Val 
1               5                   10                  15      


Phe Asn Ala Thr Phe His Ile Trp His Ser Gly Gln Phe Gly Thr Ile 
            20                  25                  30          


Asn Asn Phe Arg Leu Gly Arg Leu Pro Ser Val 
        35                  40              


<210>  81
<211>  46
<212>  PRT
<213>  artificial

<220>
<223>  TB1 250-282

<400>  81

Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Gly Gly Val Glu Asn 
1               5                   10                  15      


Gln Met Arg Tyr Ala Gln Thr Gln Leu Asp Lys Leu Lys Lys Thr Asn 
            20                  25                  30          


Val Phe Asn Ala Thr Phe Glu Ile Trp His Asp Gly Glu Phe 
        35                  40                  45      


<210>  82
<211>  38
<212>  PRT
<213>  artificial

<220>
<223>  TB1 274-298

<400>  82

Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Gly Gly Phe Glu Ile 
1               5                   10                  15      


Trp His Asp Gly Glu Phe Gly Thr Ile Asn Asn Phe Arg Leu Gly Arg 
            20                  25                  30          


Leu Pro Ser Val Pro Val 
        35              


<210>  83
<211>  42
<212>  PRT
<213>  artificial

<220>
<223>  TB1 270-298

<400>  83

Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Gly Gly Phe Asn Ala 
1               5                   10                  15      


Thr Phe Glu Ile Trp His Asp Gly Glu Phe Gly Thr Ile Asn Asn Phe 
            20                  25                  30          


Arg Leu Gly Arg Leu Pro Ser Val Pro Val 
        35                  40          


<210>  84
<211>  26
<212>  PRT
<213>  artificial

<220>
<223>  vectofusin-1

<400>  84

Lys Lys Ala Leu Leu His Ala Ala Leu Ala His Leu Leu Ala Leu Ala 
1               5                   10                  15      


His His Leu Leu Ala Leu Leu Lys Lys Ala 
            20                  25      


<210>  85
<211>  39
<212>  PRT
<213>  artificial

<220>
<223>  SEVI

<400>  85

Gly Ile His Lys Gln Lys Glu Lys Ser Arg Leu Gln Gly Gly Val Leu 
1               5                   10                  15      


Val Asn Glu Ile Leu Asn His Met Lys Arg Ala Thr Gln Ile Pro Ser 
            20                  25                  30          


Tyr Lys Lys Leu Ile Met Tyr 
        35                  


<210>  86
<211>  22
<212>  PRT
<213>  artificial

<220>
<223>  SEM1(86-107)

<400>  86

Asp Leu Asn Ala Leu His Lys Thr Thr Lys Ser Gln Arg His Leu Gly 
1               5                   10                  15      


Gly Ser Gln Gln Leu Leu 
            20          


<210>  87
<211>  12
<212>  PRT
<213>  artificial

<220>
<223>  EF-C peptide

<400>  87

Gln Cys Lys Ile Lys Gln Ile Ile Asn Met Trp Gln 
1               5                   10          


<210>  88
<211>  16
<212>  PRT
<213>  artificial

<220>
<223>  P16 peptide

<400>  88

Asn Trp Phe Asp Ile Thr Asn Trp Leu Trp Tyr Ile Lys Lys Lys Lys 
1               5                   10                  15      


<210>  89
<211>  18
<212>  PRT
<213>  artificial

<220>
<223>  Beclin-2 249-266

<400>  89

Ile Asn Cys Phe Thr Ala Thr Phe Glu Ile Trp Val Glu Gly Pro Leu 
1               5                   10                  15      


Gly Val 
        


<210>  90
<211>  29
<212>  PRT
<213>  artificial

<220>
<223>  TAT+ beclin-2

<400>  90

Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Ile Asn Cys Phe Thr 
1               5                   10                  15      


Ala Thr Phe Glu Ile Trp Val Glu Gly Pro Leu Gly Val 
            20                  25                  


<210>  91
<211>  31
<212>  PRT
<213>  artificial

<220>
<223>  TAT+ GG + Beclin2

<400>  91

Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Gly Gly Ile Asn Cys 
1               5                   10                  15      


Phe Thr Ala Thr Phe Glu Ile Trp Val Glu Gly Pro Leu Gly Val 
            20                  25                  30      


<210>  92
<211>  18
<212>  PRT
<213>  artificial

<220>
<223>  Mouse Beclin-2 262-279

<400>  92

Thr Asn Ile Phe Asn Ala Thr Phe Thr Ile Ser Asp Glu Gly Pro Leu 
1               5                   10                  15      


Gly Val 
        


<210>  93
<211>  18
<212>  PRT
<213>  artificial

<220>
<223>  Horse Beclin-2 253-270

<400>  93

Ile Asn Val Phe Ser Val Thr Phe Glu Ile Gly His Ser Gly Pro Val 
1               5                   10                  15      


Gly Val 
        


<210>  94
<211>  18
<212>  PRT
<213>  artificial

<220>
<223>  Panda Beclin-2 645-662

<400>  94

Thr Asn Val Phe Asn Ala Thr Phe Glu Ile Arg His Asp Gly Pro Val 
1               5                   10                  15      


Gly Ile 
        


<210>  95
<211>  18
<212>  PRT
<213>  artificial

<220>
<223>  Pig Beclin-2 244-261

<400>  95

Thr Asn Val Phe Arg Ala Thr Phe Glu Ile Arg His Ala Gly Pro Ile 
1               5                   10                  15      


Ala Ile 
        


<210>  96
<211>  18
<212>  PRT
<213>  artificial

<220>
<223>  Cow Beclin-2 248-265

<400>  96

Thr Asp Val Phe Asn Ala Thr Phe Glu Ile Trp Gln Asp Gly Pro Leu 
1               5                   10                  15      


Pro Val 
        


<210>  97
<211>  18
<212>  PRT
<213>  artificial

<220>
<223>  Rabbit Beclin-2 238-255

<400>  97

Thr Ser Ile Phe Gln Val Thr Phe Glu Ile Arg Glu Glu Gly Ser Val 
1               5                   10                  15      


Gly Ile 
        


<210>  98
<211>  31
<212>  PRT
<213>  artificial

<220>
<223>  tat-beclin1 H275E

<400>  98

Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Gly Gly Thr Asn Val 
1               5                   10                  15      


Phe Asn Ala Thr Phe Glu Ile Trp His Ser Gly Gln Phe Gly Thr 
            20                  25                  30      


<210>  99
<211>  31
<212>  PRT
<213>  artificial

<220>
<223>  tat-beclin 1 S279D

<400>  99

Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Gly Gly Thr Asn Val 
1               5                   10                  15      


Phe Asn Ala Thr Phe His Ile Trp His Asp Gly Gln Phe Gly Thr 
            20                  25                  30      


<210>  100
<211>  31
<212>  PRT
<213>  artificial

<220>
<223>  tat-beclin1 Q281E

<400>  100

Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Gly Gly Thr Asn Val 
1               5                   10                  15      


Phe Asn Ala Thr Phe His Ile Trp His Ser Gly Glu Phe Gly Thr 
            20                  25                  30      


<210>  101
<211>  31
<212>  PRT
<213>  artificial

<220>
<223>  tat-beclin1 F274 W277

<400>  101

Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Gly Gly Thr Asn Val 
1               5                   10                  15      


Phe Asn Ala Thr Phe His Ile Trp His Ser Gly Gln Phe Gly Thr 
            20                  25                  30      


