<110>  йũҵѧԺѧо
<120>  CRISPR-Cas9ϵͳALSÿݼˮϵͳӦ

<130>  GNPYX16008

<160>  3    

<210>  1
<211>  17778
<212>  DNA
<213>  1

<400>  1
gaattcgagc tcggtaccgc tgtgccgtac gacggtacga ggtacgagca ggtcagcggg       60
tcaccagtgt tgtgtgaagc caagctgtat tcactagctc gggatagttg gcacaaacgg      120
catgaaaatg tggcgccgta aataagtgaa atacagctgc gtactttttg aacacgctgc      180
aaacatgaga cggagaaatt tcaatgcaaa acggaaaata aaactgcaaa catgcgacgg      240
agaaaactca atgcaaaacg aaaaaaaaaa gcaccgactc ggtgccactt tttcaagttg      300
ataacggact agccttattt taacttgcta tttctagctc taaaacccca ttgcaccacc      360
ataccctgcc acggatcatc tgcacaactc ttttaaatca gctttgatct atgtggatag      420
ccgaggtggt actaatacta gtctttgttg tcgtccaatt gcgtaatggg ccggcccata      480
ctgcaataca tgtcctgaaa ggcttcatgg cccactacga aatgcttttc tcctacagtt      540
tatcttactt cttcacatca cgtggtttcc aacgtaccca gtgttcccgg cttccagcat      600
ttgctggtag caccagtaga agacgcctgt cttgtgctat ggtccctgac tgcacatctg      660
attcctccaa gatccatgca tgcctgataa ctttaagttg cttcagaaga actttaagtg      720
atctgttcgt atgtttaaag attccttgat aaaataagtt gcagttctga aaatcctaga      780
acttggagac ctggatgaat taccctggcg aaagggggat gtgctgcaag gcgattaagt      840
tgggtaacgc cagggttttc ccagtcacga cgttgtaaaa cgacggccag tgaattcccg      900
atctagtaac atagatgaca ccgcgcgcga taatttatcc tagtttgcgc gctatatttt      960
gttttctatc gcgtattaaa tgtataattg cgggactcta atcataaaaa cccatctcat     1020
aaataacgtc atgcattaca tgttaattat tacatgctta acgtaattca acagaaatta     1080
tatgataatc atcgcaagac cggcaacagg attcaatctt aagaaacttt attgccaaat     1140
gtttgaacga tcggggaaat tcggatcccc aatacttgta tgggtcgacc tgcagactgg     1200
ctgtgtataa gggagcctga catttatatt ccccagaaca tcaggttaat ggcgtttttg     1260
atgtcatttt cgcggtggct gagatcagcc acttcttccc cgataacgga gaccggcaca     1320
ctggccatat cggtggtcat catgcgccag ctttcatccc cgatatgcac caccgggtaa     1380
agttcacggg agactttatc tgacagcaga cgtgcactgg ccagggggat caccatccgt     1440
cgccctcaat cgccgccgag ttgtgagagg tcgatgcgtg tctcgtagag gcctgtgata     1500
gactggtgga tgagggtggc gtcgagaacc tccttggtag aggtgtagcg cttgcggtcg     1560
atggtggtgt cgaagtactt gaaggcggct ggagcgccga ggttggtgag ggtgaagagg     1620
tggatgatgt tctcggcctg ctcgcgaatt ggcttatcgc ggtgcttgtt gtaggcgctg     1680
agcaccttat cgaggttggc atcggcgagg atcacgcgct tggagaactc ggagatctgc     1740
tcgatgatct cgtcgaggta gtgcttgtgc tgctcgacga acagctgctt ttgctcgttg     1800
tcctctgggg agcccttgag cttctcgtag tgggaggcga ggtagaggaa gttcacgtac     1860
ttggacggga gagcaagctc gttgcccttc tgaagctcgc cagcagaggc gagcattctc     1920
ttgcggccgt tctcaagctc gaagaggctg tacttcggga gcttgatgat gaggtccttc     1980
ttcacctcct tgtagccctt ggcctcgagg aagtcgattg ggttcttctc gaagctgctg     2040
cgctccatga tcgtgatgcc cagcagctcc ttgacggact tgagcttctt gctcttgccc     2100
ttctcgacct tggcaaccac gagcacagag taggccacgg tcggagaatc gaagccgcca     2160
tacttcttcg ggtcccagtc cttcttgcgg gcgatcagct tgtcggagtt gcgctttggg     2220
aggatggact ccttggagaa gccgccggtc tgaacctcgg tcttcttcac gatgttcact     2280
tgcggcatgg agagcacctt gcgcactgtg gcgaaatccc tgcccttgtc ccacacgatc     2340
tcgcctgtct cgccgtttgt ctcgatgagc ggcctcttcc taatctcgcc gttggcgagc     2400
gtgatctcgg tcttgaagaa attcatgatg ttggagtaga agaagtactt ggcggtcgcc     2460
ttgccgatct cttgctcgga cttggcgatc atcttgcgca cgtcgtacac cttgtagtcg     2520
ccgtacacga actcggactc gagctttggg tacttcttga tgagggctgt gcccaccacg     2580
gcattgaggt aggcgtcgtg ggcgtggtgg tagttgttga tctcgcgcac cttgtagaac     2640
tggaagtcct tgcggaagtc ggacacgagc ttggacttga gggtgatgac cttcacctcg     2700
cggatgagct tgtcgttctc gtcgtacttg gtgttcatgc gggagtcgag gatctgggcc     2760
acgtgctttg tgatctggcg tgtctcgacg agctggcgct tgatgaagcc ggccttatca     2820
agctcggaaa ggccgcctct ctcggccttg gtgaggttgt cgaacttcct ctgggtgatg     2880
agcttggcgt tgaggagctg gcgccagtag ttcttcatct tcttgacgac ctcttcggac     2940
ggcacgttat cggacttgcc cctgttcttg tcggagcggg tgagcacctt gttgtcgatg     3000
gagtcgtcct tcaggaagga ctgcggcaca atatggtcca cgtcgtagtc ggagaggcgg     3060
ttgatgtcca gctcttggtc cacgtacatg tcgcggccgt tctggaggta gtagaggtag     3120
agcttctcgt tctggagctg ggtgttctcg actgggtgct ccttgaggat ctgggagccc     3180
agctccttaa tgccctcctc gatcctcttc atgcgctcgc gggagttctt ttggcccttc     3240
tgtgtggtct ggttctcgcg ggccatctcg atcacgatgt tctctggctt gtgcctgccc     3300
atcaccttca ccagctcgtc caccaccttc acggtctgga gaatgccctt cttgatagcc     3360
ggggagccgg cgagattggc gatatgctca tggagggaat cgccttggcc ggacacctgg     3420
gccttttgga tgtcctcctt gaaggtgagg gagtcgtcgt ggatgagctg catgaagttg     3480
cggttggcga agccgtcgga cttgaggaag tcgaggatcg tcttgccgga ctgcttgtcg     3540
cggatgccgt tgatgagctt cctagagagc ctgccccagc cggtatagcg cctgcgcttc     3600
agctgcttca tcaccttgtc gtcgaagagg tgggcgtatg tcttgaggcg ctcctcgatc     3660
atctcgcggt cctcgaagag ggtgagggtg agcacgatgt cctcgaggat gtcctcgttc     3720
tcctcgttgt cgaggaagtc cttgtccttg ataatcttga ggaggtcgtg gtaggtcccg     3780
agggaggcat tgaacctatc ctcgacgccg gagatctcga cggagtcgaa gcactcgatt     3840
ttcttgaagt agtcctcctt gagctgcttc acggtcacct tgcggttggt cttgaacagc     3900
aggtcgacga tggccttctt ttgctcgccg ctaaggaaag ctggcttcct catcccctcg     3960
gtcacgtact tcaccttggt cagctcgttg tacacggtga agtactcgta gaggagtgag     4020
tgcttcggga gcaccttctc gttcgggagg ttcttgtcga agttggtcat gcgctcgatg     4080
aaagactggg cagaggcgcc cttatccacc acctcctcga agttccaggg ggtgattgtc     4140
tcctcggact ttctggtcat ccaggcgaac ctggagttgc ccctggcgag cgggcccacg     4200
tagtacggga tgcggaaggt gaggatcttc tcaatcttct cgcggttgtc cttgaggaac     4260
gggtagaagt cctcttgcct gcggaggata gcatgaagct cgccgaggtg gatctggtgc     4320
gggatggagc cattatcgaa ggtgcgctgc ttgcggagga ggtcctctct attgagcttc     4380
acgagcagct cctcggtgcc gtccatcttc tcgaggatcg gcttgatgaa cttgtagaac     4440
tcctcttgag aagcgccgcc atcgatgtag ccggcgtagc cgttcttgga ctggtcgaag     4500
aagatctcct tgtacttctc tgggagctgc tgtctcacga gggccttgag gagtgtgagg     4560
tcctggtggt gctcgtcgta cctcttgatc atggaggcgg agagtggggc cttggtgatc     4620
tcggtgttca ccctgaggat gtcgctgagg aggatggcgt cggagagatt cttggcggcg     4680
aggaacagat cggcgtactg atcgccaatc tgggcgagga gattgtcgag gtcgtcgtcg     4740
taggtgtcct tggaaagctg gagcttggcg tcctcggcga ggtcgaagtt ggacttgaag     4800
ttcggggtga ggccaagaga gagggcgatc aggttgccga agaggccatt cttcttctcg     4860
cccggaagtt gggcgatcag attctcgagc ctgcgggact tagagagcct ggcagagaga     4920
atagccttgg cgtcaacgcc agaggcgttg atcgggttct cctcgaacag ctggttgtag     4980
gtctgcacga gctggatgaa cagcttgtcc acatcggagt tgtccgggtt gaggtcgccc     5040
tcgatgagga agtggcccct gaacttgatc atgtgggcga gggcgaggta gatgagcctg     5100
aggtcggcct tatcggtgga gtcgacgagc ttcttgcgga ggtggtagat ggtcgggtac     5160
ttctcgtggt aggccacctc atccacgatg ttgccgaaga tcggatggcg ctcgtgcttc     5220
ttgtcctcct cgacgaggaa gctctcctcg agcctgtgga agaagctgtc gtccaccttg     5280
gccatctcgt tggagaagat ctcttggagg tagcagatgc ggttcttgcg cctggtgtac     5340
ctgcgtctag cggtcctctt gagccttgta gcctcggctg tctcgccaga gtcgaacagc     5400
agggcgccga tgagattctt cttgatggag tggcggtcgg tgttgccgag gaccttgaac     5460
ttcttggacg gcaccttgta ctcgtcggtg atcacggccc agccaacaga attggtgccg     5520
atgtcgaggc cgatggagta cttcttgtcg accttgcgct tcttctttgg ggccatgggc     5580
tgcagaagta acaccaaaca acagggtgag catcgacaaa agaaacagta ccaagcaaat     5640
aaatagcgta tgaaggcagg gctaaaaaaa tccacatata gctgctgcat atgccatcat     5700
ccaagtatat caagatcaaa ataattataa aacatacttg tttattataa tagataggta     5760
ctcaaggtta gagcatatga atagatgctg catatgccat catgtatatg catcagtaaa     5820
acccacatca acatgtatac ctatcctaga tcgatatttc catccatctt aaactcgtaa     5880
ctatgaagat gtatgacaca cacatacagt tccaaaatta ataaatacac caggtagttt     5940
gaaacagtat tctactccga tctagaacga atgaacgacc gcccaaccac accacatcat     6000
cacaaccaag cgaacaaaaa gcatctctgt atatgcatca gtaaaacccg catcaacatg     6060
tatacctatc ctagatcgat atttccatcc atcatcttca attcgtaact atgaatatgt     6120
atggcacaca catacagatc caaaattaat aaatccacca ggtagtttga aacagaattc     6180
tactccgatc tagaacgacc gcccaaccag accacatcat cacaaccaag acaaaaaaaa     6240
gcatgaaaag atgacccgac aaacaagtgc acggcatata ttgaaataaa ggaaaagggc     6300
aaaccaaacc ctatgcaacg aaacaaaaaa aatcatgaaa tcgatcccgt ctgcggaacg     6360
gctagagcca tcccaggatt ccccaaagag aaacactggc aagttagcaa tcagaacgtg     6420
tctgacgtac aggtcgcatc cgtgtacgaa cgctagcagc acggatctaa cacaaacacg     6480
gatctaacac aaacatgaac agaagtagaa ctaccgggcc ctaaccatgg accggaacgc     6540
cgatctagag aaggtagaga gggggggggg gggaggacga gcggcgtacc ttgaagcgga     6600
ggtgccgacg ggtggatttg ggggagatct ggttgtgtgt gtgtgcgctc cgaacaacac     6660
gaggttgggg aaagagggtg tggagggggt gtctatttat tacggcgggc gaggaaggga     6720
aagcgaagga gcggtgggaa aggaatcccc cgtagctgcc gtgccgtgag aggaggagga     6780
ggccgcctgc cgtgccggct cacgtctgcc gctccgccac gcatttctgg atgccgacag     6840
cggagcaagt ccaacggtgg agcggaactc tcgagagggg tccagaggca gcgacagaga     6900
tgccgtgccg tctgcttcgc ttggcccgac gcgacgctgc tggttcgctg gttggtgtcc     6960
gttagactcg tcgacggcgt ttaacaggct ggcattatct actcgaaaca agaaaaatgt     7020
ttccttagtt tttttaattt cttaaagggt atttgtttaa tttttagtca ctttatttta     7080
ttctatttta tatctaaatt attaaataaa aaaactaaaa tagagtttta gttttcttaa     7140
tttagaggct aaaatagaat aaaatagatg tactaaaaaa attagtctat aaaaaccatt     7200
aaccctaaac cctaaatgga tgtactaata aaatggatga agtattatat aggtgaagct     7260
atttgcaaaa aaaaaggaga acacatgcac actaaaaaga taaaactgta gagtcctgtt     7320
gtcaaaatac tcaattgtcc tttagaccat gtctaactgt tcatttatat gattctctaa     7380
aacactgata ttattgtagt actatagatt atattattcg tagagtaaag tttaaatata     7440
tgtataaaga tagataaact gcacttcaaa caagtgtgac aaaaaaaata tgtggtaatt     7500
ttttataact tagacatgca atgctcatta tctctagaga ggggcacgac cgggtcacgc     7560
tgcactgcag gaattcgata tcaacatttg ggtatggtgg tgcaatggga ggatattgat     7620
ggggatggta gcttcctcat gaacattcag gagctggcat tgatccgcat tgagaacctc     7680
cctgtgaagg tgatggtgtt gaacaaccaa catttgggta tggtcgtcca gttggaggat     7740
aggttttaca aggcgaatag ggcgcataca tacttgggca acccggaatg tgagagcgag     7800
atatatccag attttgtgac tattgctaag gggttcaata ttcctgcagt ccgtgtaaca     7860
aagaagagtg aagtccgtgc cgccatcaag aagatgctcg agactccagg gccatacttg     7920
ttggacatca tcgtcccgca ccaggagcat gtgctgccta tgatcccaat tggcggggcg     7980
tttaaggaca tgatcctgga tggtgatggc aggactgtgt attaattgaa tgcgccccca     8040
cttgggatca taggcagcaa gcttggcact ggccgtcgtt ttacaacgtc gtgactggga     8100
aaaccctggc gttacccaac ttaatcgcct tgcagcacat ccccctttcg ccagctggcg     8160
taatagcgaa gaggcccgca ccgatcgccc ttcccaacag ttgcgcagcc tgaatggcga     8220
atgctagagc agcttgagct tggatcagat tgtcgtttcc cgccttcagt tgtaattcat     8280
ccaggtctcc aagttctagg attttcagaa ctgcaactta ttttatcaag gaatctttaa     8340
acatacgaac agatcactta aagttcttct gaagcaactt aaagttatca ggcatgcatg     8400
gatcttggag gaatcagatg tgcagtcagg gaccatagca caagacaggc gtcttctact     8460
ggtgctacca gcaaatgctg gaagccggga acactgggta cgttggaaac cacgtgatgt     8520
gaagaagtaa gataaactgt aggagaaaag catttcgtag tgggccatga agcctttcag     8580
gacatgtatt gcagtatggg ccggcccatt acgcaattgg acgacaacaa agactagtat     8640
tagtaccacc tcggctatcc acatagatca aagctgattt aaaagagttg tgcagatgat     8700
ccgtggcagc gcccccactt gggatcatgt tttagagcta gaaatagcaa gttaaaataa     8760
ggctagtccg ttatcaactt gaaaaagtgg caccgagtcg gtgctttttt ttttcgtttt     8820
gcattgagtt ttctccgtcg catgtttgca gttttatttt ccgttttgca ttgaaatttc     8880
tccgtctcat gtttgcagcg tgttcaaaaa gtacgcagct gtatttcact tatttacggc     8940
gccacatttt catgccgttt gtgccaacta tcccgagcta gtgaatacag cttggcttca     9000
cacaacactg gtgacccgct gacctgctcg tacctcgtac cgtcgtacgg cacagcattt     9060
ggaattaaag ggtgtgatcg atactgtaaa ctatcagtgt ttgacaggat atattggcgg     9120
gtaaacctaa gagaaaagag cgtttattag aataacggat atttaaaagg gcgtgaaaag     9180
gtttatccgt tcgtccattt gtatgtgcat gccaaccaca gggttcccct cgggatcaaa     9240
gtactttgat ccaacccctc cgctgctata gtgcagtcgg cttctgacgt tcagtgcagc     9300
cgtcttctga aaacgacatg tcgcacaagt cctaagttac gcgacaggct gccgccctgc     9360
ccttttcctg gcgttttctt gtcgcgtgtt ttagtcgcat aaagtagaat acttgcgact     9420
agaaccggag acattacgcc atgaacaaga gcgccgccgc tggcctgctg ggctatgccc     9480
gcgtcagcac cgacgaccag gacttgacca accaacgggc cgaactgcac gcggccggct     9540
gcaccaagct gttttccgag aagatcaccg gcaccaggcg cgaccgcccg gagctggcca     9600
ggatgcttga ccacctagcc ctggcgacgt tgtgacagtg accaggctag accgcctggc     9660
ccgcagcacc cgcgacctac tggacattgc cgagcgcatc caggaggccg gcgcgggcct     9720
gcgtagcctg gcagagccgt gggccgacac caccacgccg gccggccgca tggtgttgac     9780
cgtgttcgcc ggcattgccg agttcgagcg ttccctaatc atcgaccgca cccggagcgg     9840
gcgcgaggcc gccaaggccc gaggcgtgaa gtttggcccc cgccctaccc tcaccccggc     9900
acagatcgcg cacgcccgcg agctgatcga ccaggaaggc cgcaccgtga aagaggcggc     9960
tgcactgctt ggcgtgcatc gctcgaccct gtaccgcgca cttgagcgca gcgaggaagt    10020
gacgcccacc gaggccaggc ggcgcggtgc cttccgtgag gacgcattga ccgaggccga    10080
cgccctggcg gccgccgaga atgaacgcca agaggaacaa gcatgaaacc gcaccaggac    10140
ggccaggacg aaccgttttt cattaccgaa gagatcgagg cggagatgat cgcggccggg    10200
tacgtgttcg agccgcccgc gcacgtctca accgtgcggc tgcatgaaat cctggccggt    10260
ttgtctgatg ccaagctggc ggcctggccg gccagcttgg ccgctgaaga aaccgagcgc    10320
cgccgtctaa aaaggtgatg tgtatttgag taaaacagct tgcgtcatgc ggtcgctgcg    10380
tatatgatgc gatgagtaaa taaacaaata cgcaagggga acgcatgaag gttatcgctg    10440
tacttaacca gaaaggcggg tcaggcaaga cgaccatcgc aacccatcta gcccgcgccc    10500
tgcaactcgc cggggccgat gttctgttag tcgattccga tccccagggc agtgcccgcg    10560
attgggcggc cgtgcgggaa gatcaaccgc taaccgttgt cggcatcgac cgcccgacga    10620
ttgaccgcga cgtgaaggcc atcggccggc gcgacttcgt agtgatcgac ggagcgcccc    10680
aggcggcgga cttggctgtg tccgcgatca aggcagccga cttcgtgctg attccggtgc    10740
agccaagccc ttacgacata tgggcaaccg ccgacctggt ggagctggtt aagcagcgca    10800
ttgaggtcac ggatggaagg ctacaagcgg cctttgtcgt gtcgcgggcg atcaaaggca    10860
cgcgcatcgg cggtgaggtt gccgaggcgc tggccgggta cgagctgccc attcttgagt    10920
cccgtatcac gcagcgcgtg agctacccag gcactgccgc cgccggcaca accgttcttg    10980
aatcagaacc cgagggcgac gctgcccgcg aggtccaggc gctggccgct gaaattaaat    11040
caaaactcat ttgagttaat gaggtaaaga gaaaatgagc aaaagcacaa acacgctaag    11100
tgccggccgt ccgagcgcac gcagcagcaa ggctgcaacg ttggccagcc tggcagacac    11160
gccagccatg aagcgggtca actttcagtt gccggcggag gatcacacca agctgaagat    11220
gtacgcggta cgccaaggca agaccattac cgagctgcta tctgaataca tcgcgcagct    11280
accagagtaa atgagcaaat gaataaatga gtagatgaat tttagcggct aaaggaggcg    11340
gcatggaaaa tcaagaacaa ccaggcaccg acgccgtgga atgccccatg tgtggaggaa    11400
cgggcggttg gccaggcgta agcggctggg ttgtctgccg gccctgcaat ggcactggaa    11460
cccccaagcc cgaggaatcg gcgtgacggt cgcaaaccat ccggcccggt acaaatcggc    11520
gcggcgctgg gtgatgacct ggtggagaag ttgaaggccg cgcaggccgc ccagcggcaa    11580
cgcatcgagg cagaagcacg ccccggtgaa tcgtggcaag cggccgctga tcgaatccgc    11640
aaagaatccc ggcaaccgcc ggcagccggt gcgccgtcga ttaggaagcc gcccaagggc    11700
gacgagcaac cagatttttt cgttccgatg ctctatgacg tgggcacccg cgatagtcgc    11760
agcatcatgg acgtggccgt tttccgtctg tcgaagcgtg accgacgagc tggcgaggtg    11820
atccgctacg agcttccaga cgggcacgta gaggtttccg cagggccggc cggcatggcc    11880
agtgtgtggg attacgacct ggtactgatg gcggtttccc atctaaccga atccatgaac    11940
cgataccggg aagggaaggg agacaagccc ggccgcgtgt tccgtccaca cgttgcggac    12000
gtactcaagt tctgccggcg agccgatggc ggaaagcaga aagacgacct ggtagaaacc    12060
tgcattcggt taaacaccac gcacgttgcc atgcagcgta cgaagaaggc caagaacggc    12120
cgcctggtga cggtatccga gggtgaagcc ttgattagcc gctacaagat cgtaaagagc    12180
gaaaccgggc ggccggagta catcgagatc gagctagctg attggatgta ccgcgagatc    12240
acagaaggca agaacccgga cgtgctgacg gttcaccccg attacttttt gatcgatccc    12300
ggcatcggcc gttttctcta ccgcctggca cgccgcgccg caggcaaggc agaagccaga    12360
tggttgttca agacgatcta cgaacgcagt ggcagcgccg gagagttcaa gaagttctgt    12420
ttcaccgtgc gcaagctgat cgggtcaaat gacctgccgg agtacgattt gaaggaggag    12480
gcggggcagg ctggcccgat cctagtcatg cgctaccgca acctgatcga gggcgaagca    12540
tccgccggtt cctaatgtac ggagcagatg ctagggcaaa ttgccctagc aggggaaaaa    12600
ggtcgaaaag gtctctttcc tgtggatagc acgtacattg ggaacccaaa gccgtacatt    12660
gggaaccgga acccgtacat tgggaaccca aagccgtaca ttgggaaccg gtcacacatg    12720
taagtgactg atataaaaga gaaaaaaggc gatttttccg cctaaaactc tttaaaactt    12780
attaaaactc ttaaaacccg cctggcctgt gcataactgt ctggccagcg cacagccgaa    12840
gagctgcaaa aagcgcctac ccttcggtcg ctgcgctccc tacgccccgc cgcttcgcgt    12900
cggcctatcg cggccgctgg ccgctcaaaa atggctggcc tacggccagg caatctacca    12960
gggcgcggac aagccgcgcc gtcgccactc gaccgccggc gcccacatca aggcaccctg    13020
cctcgcgcgt ttcggtgatg acggtgaaaa cctctgacac atgcagctcc cggagacggt    13080
cacagcttgt ctgtaagcgg atgccgggag cagacaagcc cgtcagggcg cgtcagcggg    13140
tgttggcggg tgtcggggcg cagccatgac ccagtcacgt agcgatagcg gagtgtatac    13200
tggcttaact atgcggcatc agagcagatt gtactgagag tgcaccatat gcggtgtgaa    13260
ataccgcaca gatgcgtaag gagaaaatac cgcatcaggc gctcttccgc ttcctcgctc    13320
actgactcgc tgcgctcggt cgttcggctg cggcgagcgg tatcagctca ctcaaaggcg    13380
gtaatacggt tatccacaga atcaggggat aacgcaggaa agaacatgtg agcaaaaggc    13440
cagcaaaagg ccaggaaccg taaaaaggcc gcgttgctgg cgtttttcca taggctccgc    13500
ccccctgacg agcatcacaa aaatcgacgc tcaagtcaga ggtggcgaaa cccgacagga    13560
ctataaagat accaggcgtt tccccctgga agctccctcg tgcgctctcc tgttccgacc    13620
ctgccgctta ccggatacct gtccgccttt ctcccttcgg gaagcgtggc gctttctcat    13680
agctcacgct gtaggtatct cagttcggtg taggtcgttc gctccaagct gggctgtgtg    13740
cacgaacccc ccgttcagcc cgaccgctgc gccttatccg gtaactatcg tcttgagtcc    13800
aacccggtaa gacacgactt atcgccactg gcagcagcca ctggtaacag gattagcaga    13860
gcgaggtatg taggcggtgc tacagagttc ttgaagtggt ggcctaacta cggctacact    13920
agaaggacag tatttggtat ctgcgctctg ctgaagccag ttaccttcgg aaaaagagtt    13980
ggtagctctt gatccggcaa acaaaccacc gctggtagcg gtggtttttt tgtttgcaag    14040
cagcagatta cgcgcagaaa aaaaggatct caagaagatc ctttgatctt ttctacgggg    14100
tctgacgctc agtggaacga aaactcacgt taagggattt tggtcatgca ttctaggtac    14160
taaaacaatt catccagtaa aatataatat tttattttct cccaatcagg cttgatcccc    14220
agtaagtcaa aaaatagctc gacatactgt tcttccccga tatcctccct gatcgaccgg    14280
acgcagaagg caatgtcata ccacttgtcc gccctgccgc ttctcccaag atcaataaag    14340
ccacttactt tgccatcttt cacaaagatg ttgctgtctc ccaggtcgcc gtgggaaaag    14400
acaagttcct cttcgggctt ttccgtcttt aaaaaatcat acagctcgcg cggatcttta    14460
aatggagtgt cttcttccca gttttcgcaa tccacatcgg ccagatcgtt attcagtaag    14520
taatccaatt cggctaagcg gctgtctaag ctattcgtat agggacaatc cgatatgtcg    14580
atggagtgaa agagcctgat gcactccgca tacagctcga taatcttttc agggctttgt    14640
tcatcttcat actcttccga gcaaaggacg ccatcggcct cactcatgag cagattgctc    14700
cagccatcat gccgttcaaa gtgcaggacc tttggaacag gcagctttcc ttccagccat    14760
agcatcatgt ccttttcccg ttcaacatca taggtggtcc ctttataccg gctgtccgtc    14820
atttttaaat ataggttttc attttctccc accagcttat ataccttagc aggagacatt    14880
ccttccgtat cttttacgca gcggtatttt tcgatcagtt ttttcaattc cggtgatatt    14940
ctcattttag ccatttatta tttccttcct cttttctaca gtatttaaag ataccccaag    15000
aagctaatta taacaagacg aactccaatt cactgttcct tgcattctaa aaccttaaat    15060
accagaaaac agctttttca aagttgtttt caaagttggc gtataacata gtatcgacgg    15120
agccgatttt gaaaccgcgg tgatcacagg cagcaacgct ctgtcatcgt tacaatcaac    15180
atgctaccct ccgcgagatc atccgtgttt caaacccggc agcttagttg ccgttcttcc    15240
gaatagcatc ggtaacatga gcaaagtctg ccgccttaca acggctctcc cgctgacgcc    15300
gtcccggact gatgggctgc ctgtatcgag tggtgatttt gtgccgagct gccggtcggg    15360
gagctgttgg ctggctggtg gcaggatata ttgtggtgta aacaaattga cgcttagaca    15420
acttaataac acattgcgga cgtttttaat gtactgaatt aacgccgaat taattcgggg    15480
gatctggatt ttagtactgg attttggttt taggaattag aaattttatt gatagaagta    15540
ttttacaaat acaaatacat actaagggtt tcttatatgc tcaacacatg agcgaaaccc    15600
tataggaacc ctaattccct tatctgggaa ctactcacac attattatgg agaaactcga    15660
gcttgtcgat cgacagatcc ggtcggcatc tactctattt ctttgccctc ggacgagtgc    15720
tggggcgtcg gtttccacta tcggcgagta cttctacaca gccatcggtc cagacggccg    15780
cgcttctgcg ggcgatttgt gtacgcccga cagtcccggc tccggatcgg acgattgcgt    15840
cgcatcgacc ctgcgcccaa gctgcatcat cgaaattgcc gtcaaccaag ctctgataga    15900
gttggtcaag accaatgcgg agcatatacg cccggagtcg tggcgatcct gcaagctccg    15960
gatgcctccg ctcgaagtag cgcgtctgct gctccataca agccaaccac ggcctccaga    16020
agaagatgtt ggcgacctcg tattgggaat ccccgaacat cgcctcgctc cagtcaatga    16080
ccgctgttat gcggccattg tccgtcagga cattgttgga gccgaaatcc gcgtgcacga    16140
ggtgccggac ttcggggcag tcctcggccc aaagcatcag ctcatcgaga gcctgcgcga    16200
cggacgcact gacggtgtcg tccatcacag tttgccagtg atacacatgg ggatcagcaa    16260
tcgcgcatat gaaatcacgc catgtagtgt attgaccgat tccttgcggt ccgaatgggc    16320
cgaacccgct cgtctggcta agatcggccg cagcgatcgc atccatagcc tccgcgaccg    16380
gttgtagaac agcgggcagt tcggtttcag gcaggtcttg caacgtgaca ccctgtgcac    16440
ggcgggagat gcaataggtc aggctctcgc taaactcccc aatgtcaagc acttccggaa    16500
tcgggagcgc ggccgatgca aagtgccgat aaacataacg atctttgtag aaaccatcgg    16560
cgcagctatt tacccgcagg acatatccac gccctcctac atcgaagctg aaagcacgag    16620
attcttcgcc ctccgagagc tgcatcaggt cggagacgct gtcgaacttt tcgatcagaa    16680
acttctcgac agacgtcgcg gtgagttcag gctttttcat atctcattgc cccccggatc    16740
tgcgaaagct cgagagagat agatttgtag agagagactg gtgatttcag cgtgtcctct    16800
ccaaatgaaa tgaacttcct tatatagagg aaggtcttgc gaaggatagt gggattgtgc    16860
gtcatccctt acgtcagtgg agatatcaca tcaatccact tgctttgaag acgtggttgg    16920
aacgtcttct ttttccacga tgctcctcgt gggtgggggt ccatctttgg gaccactgtc    16980
ggcagaggca tcttgaacga tagcctttcc tttatcgcaa tgatggcatt tgtaggtgcc    17040
accttccttt tctactgtcc ttttgatgaa gtgacagata gctgggcaat ggaatccgag    17100
gaggtttccc gatattaccc tttgttgaaa agtctcaata gccctttggt cttctgagac    17160
tgtatctttg atattcttgg agtagacgag agtgtcgtgc tccaccatgt tatcacatca    17220
atccacttgc tttgaagacg tggttggaac gtcttctttt tccacgatgc tcctcgtggg    17280
tgggggtcca tctttgggac cactgtcggc agaggcatct tgaacgatag cctttccttt    17340
atcgcaatga tggcatttgt aggtgccacc ttccttttct actgtccttt tgatgaagtg    17400
acagatagct gggcaatgga atccgaggag gtttcccgat attacccttt gttgaaaagt    17460
ctcaatagcc ctttggtctt ctgagactgt atctttgata ttcttggagt agacgagagt    17520
gtcgtgctcc accatgttgg caagctgctc tagccaatac gcaaaccgcc tctccccgcg    17580
cgttggccga ttcattaatg cagctggcac gacaggtttc ccgactggaa agcgggcagt    17640
gagcgcaacg caattaatgt gagttagctc actcattagg caccccaggc tttacacttt    17700
atgcttccgg ctcgtatgtt gtgtggaatt gtgagcggat aacaatttca cacaggaaac    17760
agctatgacc atgattac                                                  17778


<210>  2
<211> 644
<212> PRT
<213>  ˹

<220>

<223> 

<400>  2
Met Ala Thr Thr Ala Ala Ala Ala Ala Ala Ala Leu Ser Ala Ala Ala 
1               5                   10                  15      
Thr Ala Lys Thr Gly Arg Lys Asn His Gln Arg His His Val Leu Pro 
            20                  25                  30          
Ala Arg Gly Arg Val Gly Ala Ala Ala Val Arg Cys Ser Ala Val Ser 
        35                  40                  45              
Pro Val Thr Pro Pro Ser Pro Ala Pro Pro Ala Thr Pro Leu Arg Pro 
    50                  55                  60                  
Trp Gly Pro Ala Glu Pro Arg Lys Gly Ala Asp Ile Leu Val Glu Ala 
65                  70                  75                  80  
Leu Glu Arg Cys Gly Val Ser Asp Val Phe Ala Tyr Pro Gly Gly Ala 
                85                  90                  95      
Ser Met Glu Ile His Gln Ala Leu Thr Arg Ser Pro Val Ile Thr Asn 
            100                 105                 110         
His Leu Phe Arg His Glu Gln Gly Glu Ala Phe Ala Ala Ser Gly Tyr 
        115                 120                 125             
Ala Arg Ala Ser Gly Arg Val Gly Val Cys Val Ala Thr Ser Gly Pro 
    130                 135                 140                 
Gly Ala Thr Asn Leu Val Ser Ala Leu Ala Asp Ala Leu Leu Asp Ser 
145                 150                 155                 160 
Val Pro Met Val Ala Ile Thr Gly Gln Val Pro Arg Arg Met Ile Gly 
                165                 170                 175     
Thr Asp Ala Phe Gln Glu Thr Pro Ile Val Glu Val Thr Arg Ser Ile 
            180                 185                 190         
Thr Lys His Asn Tyr Leu Val Leu Asp Val Glu Asp Ile Pro Arg Val 
        195                 200                 205             
Ile Gln Glu Ala Phe Phe Leu Ala Ser Ser Gly Arg Pro Gly Pro Val 
    210                 215                 220                 
Leu Val Asp Ile Pro Lys Asp Ile Gln Gln Gln Met Ala Val Pro Val 
225                 230                 235                 240 
Trp Asp Thr Ser Met Asn Leu Pro Gly Tyr Ile Ala Arg Leu Pro Lys 
                245                 250                 255     
Pro Pro Ala Thr Glu Leu Leu Glu Gln Val Leu Arg Leu Val Gly Glu 
            260                 265                 270         
Ser Arg Arg Pro Ile Leu Tyr Val Gly Gly Gly Cys Ser Ala Ser Gly 
        275                 280                 285             
Asp Glu Leu Arg Trp Phe Val Glu Leu Thr Gly Ile Pro Val Thr Thr 
    290                 295                 300                 
Thr Leu Met Gly Leu Gly Asn Phe Pro Ser Asp Asp Pro Leu Ser Leu 
305                 310                 315                 320 
Arg Met Leu Gly Met His Gly Thr Val Tyr Ala Asn Tyr Ala Val Asp 
                325                 330                 335     
Lys Ala Asp Leu Leu Leu Ala Phe Gly Val Arg Phe Asp Asp Arg Val 
            340                 345                 350         
Thr Gly Lys Ile Glu Ala Phe Ala Ser Arg Ala Lys Ile Val His Ile 
        355                 360                 365             
Asp Ile Asp Pro Ala Glu Ile Gly Lys Asn Lys Gln Pro His Val Ser 
    370                 375                 380                 
Ile Cys Ala Asp Val Lys Leu Ala Leu Gln Gly Leu Asn Ala Leu Leu 
385                 390                 395                 400 
Gln Gln Ser Thr Thr Lys Thr Ser Ser Asp Phe Ser Ala Trp His Asn 
                405                 410                 415     
Glu Leu Asp Gln Gln Lys Arg Glu Phe Pro Leu Gly Tyr Lys Thr Phe 
            420                 425                 430         
Gly Glu Glu Ile Pro Pro Gln Tyr Ala Ile Gln Val Leu Asp Glu Leu 
        435                 440                 445             
Thr Lys Gly Glu Ala Ile Ile Ala Thr Gly Val Gly Gln His Gln Met 
    450                 455                 460                 
Trp Ala Ala Gln Tyr Tyr Thr Tyr Lys Arg Pro Arg Gln Trp Leu Ser 
465                 470                 475                 480 
Ser Ala Gly Leu Gly Ala Met Gly Phe Gly Leu Pro Ala Ala Ala Gly 
                485                 490                 495     
Ala Ser Val Ala Asn Pro Gly Val Thr Val Val Asp Ile Asp Gly Asp 
            500                 505                 510         
Gly Ser Phe Leu Met Asn Ile Gln Glu Leu Ala Leu Ile Arg Ile Glu 
        515                 520                 525             
Asn Leu Pro Val Lys Val Met Val Leu Asn Asn Gln His Leu Gly Met 
    530                 535                 540                 
Val Val Gln Trp Glu Asp Arg Phe Tyr Lys Ala Asn Arg Ala His Thr 
545                 550                 555                 560 
Tyr Leu Gly Asn Pro Glu Cys Glu Ser Glu Ile Tyr Pro Asp Phe Val 
                565                 570                 575     
Thr Ile Ala Lys Gly Phe Asn Ile Pro Ala Val Arg Val Thr Lys Lys 
            580                 585                 590         
Ser Glu Val Arg Ala Ala Ile Lys Lys Met Leu Glu Thr Pro Gly Pro 
        595                 600                 605             
Tyr Leu Leu Asp Ile Ile Val Pro His Gln Glu His Val Leu Pro Met 
    610                 615                 620                 
Ile Pro Ser Gly Gly Ala Phe Lys Asp Met Ile Leu Asp Gly Asp Gly 
625                 630                 635                 640 
Arg Thr Val Tyr 
                
<210>  3
<211>  1935
<212>  DNA
<213>  ˹

<220>

<223> 

<400>  3
atggctacga ccgccgcggc cgcggccgcc gccctgtccg ccgccgcgac ggccaagacc        60
ggccgtaaga accaccagcg acaccacgtc cttcccgctc gaggccgggt gggggcggcg       120
gcggtcaggt gctcggcggt gtccccggtc accccgccgt ccccggcgcc gccggccacg       180
ccgctccggc cgtgggggcc ggccgagccc cgcaagggcg cggacatcct cgtggaggcg       240
ctggagcggt gcggcgtcag cgacgtgttc gcctacccgg gcggcgcgtc catggagatc       300
caccaggcgc tgacgcgctc cccggtcatc accaaccacc tcttccgcca cgagcagggc       360
gaggcgttcg cggcgtccgg gtacgcgcgc gcgtccggcc gcgtcggggt ctgcgtcgcc       420
acctccggcc ccggggcaac caacctcgtg tccgcgctcg ccgacgcgct gctcgactcc       480
gtcccgatgg tcgccatcac gggccaggtc ccccgccgca tgatcggcac cgacgccttc       540
caggagacgc ccatagtcga ggtcacccgc tccatcacca agcacaatta ccttgtcctt       600
gatgtggagg acatcccccg cgtcatacag gaagccttct tcctcgcgtc ctcgggccgt       660
cctggcccgg tgctggtcga catccccaag gacatccagc agcagatggc cgtgccggtc       720
tgggacacct cgatgaatct accagggtac atcgcacgcc tgcccaagcc acccgcgaca       780
gaattgcttg agcaggtctt gcgtctggtt ggcgagtcac ggcgcccgat tctctatgtc       840
ggtggtggct gctctgcatc tggtgacgaa ttgcgctggt ttgttgagct gactggtatc       900
ccagttacaa ccactctgat gggcctcggc aatttcccca gtgacgaccc gttgtccctg       960
cgcatgcttg ggatgcatgg cacggtgtac gcaaattatg ccgtggataa ggctgacctg      1020
ttgcttgcgt ttggtgtgcg gtttgatgat cgtgtgacag ggaaaattga ggcttttgca      1080
agcagggcca agattgtgca cattgacatt gatccagcag agattggaaa gaacaagcaa      1140
ccacatgtgt caatttgcgc agatgttaag cttgctttac agggcttgaa tgctctgcta      1200
caacagagca caacaaagac aagttctgat tttagtgcat ggcacaatga gttggaccag      1260
cagaagaggg agtttcctct ggggtacaaa acttttggtg aagagatccc accgcaatat      1320
gccattcagg tgctggatga gctgacgaaa ggtgaggcaa tcatcgctac tggtgttggg      1380
cagcaccaga tgtgggcggc acaatattac acctacaagc ggccacggca gtggctgtct      1440
tcggctggtc tgggcgcaat gggatttggg ctgcctgctg cagctggtgc ttctgtggct      1500
aacccaggtg tcacagttgt tgatattgat ggggatggta gcttcctcat gaacattcag      1560
gagctggcat tgatccgcat tgagaacctc cctgtgaagg tgatggtgtt gaacaaccaa      1620
catttgggta tggtggtgca atgggaggat aggttttaca aggcgaatag ggcgcataca      1680
tacttgggca acccggaatg tgagagcgag atatatccag attttgtgac tattgctaag      1740
gggttcaata ttcctgcagt ccgtgtaaca aagaagagtg aagtccgtgc cgccatcaag      1800
aagatgctcg agactccagg gccatacttg ttggatatca tcgtcccgca ccaggagcat      1860
gtgctgccta tgatcccaag tgggggcgca ttcaaggaca tgatcctgga tggtgatggc      1920
aggactgtgt attaa                                                       1935

