                         SEQUENCE LISTING

<110>  University of Miami
 
<120>  PEPTIDE INHIBITORS FOR CALCINEURIN

<130>  32286/50044A

<150>  US 62/260,144
<151>  2015-11-25

<160>  5     

<170>  PatentIn version 3.5

<210>  1
<211>  515
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(27)
<223>  Polyproline domain

<400>  1

Met Ala Ala Pro Glu Pro Ala Arg Ala Ala Pro Pro Pro Pro Pro Pro 
1               5                   10                  15      


Pro Pro Pro Pro Pro Gly Ala Asp Arg Val Val Lys Ala Val Pro Phe 
            20                  25                  30          


Pro Pro Thr His Arg Leu Thr Ser Glu Glu Val Phe Asp Leu Asp Gly 
        35                  40                  45              


Ile Pro Arg Val Asp Val Leu Lys Asn His Leu Val Lys Glu Gly Arg 
    50                  55                  60                  


Val Asp Glu Glu Ile Ala Leu Arg Ile Ile Asn Glu Gly Ala Ala Ile 
65                  70                  75                  80  


Leu Arg Arg Glu Lys Thr Met Ile Glu Val Glu Ala Pro Ile Thr Val 
                85                  90                  95      


Cys Gly Asp Ile His Gly Gln Phe Phe Asp Leu Met Lys Leu Phe Glu 
            100                 105                 110         


Val Gly Gly Ser Pro Ala Asn Thr Arg Tyr Leu Phe Leu Gly Asp Tyr 
        115                 120                 125             


Val Asp Arg Gly Tyr Phe Ser Ile Glu Cys Val Leu Tyr Leu Trp Val 
    130                 135                 140                 


Leu Lys Ile Leu Tyr Pro Ser Thr Leu Phe Leu Leu Arg Gly Asn His 
145                 150                 155                 160 


Glu Cys Arg His Leu Thr Glu Tyr Phe Thr Phe Lys Gln Glu Cys Lys 
                165                 170                 175     


Ile Lys Tyr Ser Glu Arg Val Tyr Glu Ala Cys Met Glu Ala Phe Asp 
            180                 185                 190         


Ser Leu Pro Leu Ala Ala Leu Leu Asn Gln Gln Phe Leu Cys Val His 
        195                 200                 205             


Gly Gly Leu Ser Pro Glu Ile His Thr Leu Asp Asp Ile Arg Arg Leu 
    210                 215                 220                 


Asp Arg Phe Lys Glu Pro Pro Ala Phe Gly Pro Met Cys Asp Leu Leu 
225                 230                 235                 240 


Trp Ser Asp Pro Ser Glu Asp Phe Gly Asn Glu Lys Ser Gln Glu His 
                245                 250                 255     


Phe Ser His Asn Thr Val Arg Gly Cys Ser Tyr Phe Tyr Asn Tyr Pro 
            260                 265                 270         


Ala Val Cys Glu Phe Leu Gln Asn Asn Asn Leu Leu Ser Ile Ile Arg 
        275                 280                 285             


Ala His Glu Ala Gln Asp Ala Gly Tyr Arg Met Tyr Arg Lys Ser Gln 
    290                 295                 300                 


Thr Thr Gly Phe Pro Ser Leu Ile Thr Ile Phe Ser Ala Pro Asn Tyr 
305                 310                 315                 320 


Leu Asp Val Tyr Asn Asn Lys Ala Ala Val Leu Lys Tyr Glu Asn Asn 
                325                 330                 335     


Val Met Asn Ile Arg Gln Phe Asn Cys Ser Pro His Pro Tyr Trp Leu 
            340                 345                 350         


Pro Asn Phe Met Asp Val Phe Thr Trp Ser Leu Pro Phe Val Gly Glu 
        355                 360                 365             


Lys Val Thr Glu Met Leu Val Asn Val Leu Ser Ile Cys Ser Asp Asp 
    370                 375                 380                 


Glu Leu Met Thr Glu Gly Glu Asp Gln Phe Asp Val Gly Ser Ala Ala 
385                 390                 395                 400 


Ala Arg Lys Glu Ile Ile Arg Asn Lys Ile Arg Ala Ile Gly Lys Met 
                405                 410                 415     


Ala Arg Val Phe Ser Val Leu Arg Glu Glu Ser Glu Ser Val Leu Thr 
            420                 425                 430         


Leu Lys Gly Leu Thr Pro Thr Gly Met Leu Pro Ser Gly Val Leu Ala 
        435                 440                 445             


Gly Gly Arg Gln Thr Leu Gln Ser Ala Ile Arg Gly Phe Ser Pro Pro 
    450                 455                 460                 


His Arg Ile Cys Ser Phe Glu Glu Ala Lys Gly Leu Asp Arg Ile Asn 
465                 470                 475                 480 


Glu Arg Met Pro Pro Arg Lys Asp Ala Val Gln Gln Asp Gly Phe Asn 
                485                 490                 495     


Ser Leu Asn Thr Ala His Ala Thr Glu Asn His Gly Thr Gly Asn His 
            500                 505                 510         


Thr Ala Gln 
        515 


<210>  2
<211>  545
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (457)..(545)
<223>  SH3 Domain

<400>  2

Met Asp Trp Gly Thr Glu Leu Trp Asp Gln Phe Glu Val Leu Glu Arg 
1               5                   10                  15      


His Thr Gln Trp Gly Leu Asp Leu Leu Asp Arg Tyr Val Lys Phe Val 
            20                  25                  30          


Lys Glu Arg Thr Glu Val Glu Gln Ala Tyr Ala Lys Gln Leu Arg Ser 
        35                  40                  45              


Leu Val Lys Lys Tyr Leu Pro Lys Arg Pro Ala Lys Asp Asp Pro Glu 
    50                  55                  60                  


Ser Lys Phe Ser Gln Gln Gln Ser Phe Val Gln Ile Leu Gln Glu Val 
65                  70                  75                  80  


Asn Asp Phe Ala Gly Gln Arg Glu Leu Val Ala Glu Asn Leu Ser Val 
                85                  90                  95      


Arg Val Cys Leu Glu Leu Thr Lys Tyr Ser Gln Glu Met Lys Gln Glu 
            100                 105                 110         


Arg Lys Met His Phe Gln Glu Gly Arg Arg Ala Gln Gln Gln Leu Glu 
        115                 120                 125             


Asn Gly Phe Lys Gln Leu Glu Asn Ser Lys Arg Lys Phe Glu Arg Asp 
    130                 135                 140                 


Cys Arg Glu Ala Glu Lys Ala Ala Gln Thr Ala Glu Arg Leu Asp Gln 
145                 150                 155                 160 


Asp Ile Asn Ala Thr Lys Ala Asp Val Glu Lys Ala Lys Gln Gln Ala 
                165                 170                 175     


His Leu Arg Ser His Met Ala Glu Glu Ser Lys Asn Glu Tyr Ala Ala 
            180                 185                 190         


Gln Leu Gln Arg Phe Asn Arg Asp Gln Ala His Phe Tyr Phe Ser Gln 
        195                 200                 205             


Met Pro Gln Ile Phe Asp Lys Leu Gln Asp Met Asp Glu Arg Arg Ala 
    210                 215                 220                 


Thr Arg Leu Gly Ala Gly Tyr Gly Leu Leu Ser Glu Ala Glu Leu Glu 
225                 230                 235                 240 


Val Val Pro Ile Ile Ala Lys Cys Leu Glu Gly Met Lys Val Ala Ala 
                245                 250                 255     


Asn Ala Val Asp Pro Lys Asn Asp Ser His Val Leu Ile Glu Leu His 
            260                 265                 270         


Lys Ser Gly Phe Ala Arg Pro Gly Asp Val Glu Phe Glu Asp Phe Ser 
        275                 280                 285             


Gln Pro Met Asn Arg Ala Pro Ser Asp Ser Ser Leu Gly Thr Pro Ser 
    290                 295                 300                 


Asp Gly Arg Pro Glu Leu Arg Gly Pro Gly Arg Ser Arg Thr Lys Arg 
305                 310                 315                 320 


Trp Pro Phe Gly Lys Lys Asn Lys Thr Val Val Thr Glu Asp Phe Ser 
                325                 330                 335     


His Leu Pro Pro Glu Gln Gln Arg Lys Arg Leu Gln Gln Gln Leu Glu 
            340                 345                 350         


Glu Arg Ser Arg Glu Leu Gln Lys Glu Val Asp Gln Arg Glu Ala Leu 
        355                 360                 365             


Lys Lys Met Lys Asp Val Tyr Glu Lys Thr Pro Gln Met Gly Asp Pro 
    370                 375                 380                 


Ala Ser Leu Glu Pro Gln Ile Ala Glu Thr Leu Ser Asn Ile Glu Arg 
385                 390                 395                 400 


Leu Lys Leu Glu Val Gln Lys Tyr Glu Ala Trp Leu Ala Glu Ala Glu 
                405                 410                 415     


Ser Arg Val Leu Ser Asn Arg Gly Asp Ser Leu Ser Arg His Ala Arg 
            420                 425                 430         


Pro Pro Asp Pro Pro Ala Ser Ala Pro Pro Asp Ser Ser Ser Asn Ser 
        435                 440                 445             


Ala Ser Gln Asp Thr Lys Glu Ser Ser Glu Glu Pro Pro Ser Glu Glu 
    450                 455                 460                 


Ser Gln Asp Thr Pro Ile Tyr Thr Glu Phe Asp Glu Asp Phe Glu Glu 
465                 470                 475                 480 


Glu Pro Thr Ser Pro Ile Gly His Cys Val Ala Ile Tyr His Phe Glu 
                485                 490                 495     


Gly Ser Ser Glu Gly Thr Ile Ser Met Ala Glu Gly Glu Asp Leu Ser 
            500                 505                 510         


Leu Met Glu Glu Asp Lys Gly Asp Gly Trp Thr Arg Val Arg Arg Lys 
        515                 520                 525             


Glu Gly Gly Glu Gly Tyr Val Pro Thr Ser Tyr Leu Arg Val Thr Leu 
    530                 535                 540                 


Asn 
545 


<210>  3
<211>  2319
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1288)..(1347)
<223>  Calcineurin binding domain

<400>  3

Met Leu Thr Met Ser Val Thr Leu Ser Pro Leu Arg Ser Gln Asp Leu 
1               5                   10                  15      


Asp Pro Met Ala Thr Asp Ala Ser Pro Met Ala Ile Asn Met Thr Pro 
            20                  25                  30          


Thr Val Glu Gln Gly Glu Gly Glu Glu Ala Met Lys Asp Met Asp Ser 
        35                  40                  45              


Asp Gln Gln Tyr Glu Lys Pro Pro Pro Leu His Thr Gly Ala Asp Trp 
    50                  55                  60                  


Lys Ile Val Leu His Leu Pro Glu Ile Glu Thr Trp Leu Arg Met Thr 
65                  70                  75                  80  


Ser Glu Arg Val Arg Asp Leu Thr Tyr Ser Val Gln Gln Asp Ser Asp 
                85                  90                  95      


Ser Lys His Val Asp Val His Leu Val Gln Leu Lys Asp Ile Cys Glu 
            100                 105                 110         


Asp Ile Ser Asp His Val Glu Gln Ile His Ala Leu Leu Glu Thr Glu 
        115                 120                 125             


Phe Ser Leu Lys Leu Leu Ser Tyr Ser Val Asn Val Ile Val Asp Ile 
    130                 135                 140                 


His Ala Val Gln Leu Leu Trp His Gln Leu Arg Val Ser Val Leu Val 
145                 150                 155                 160 


Leu Arg Glu Arg Ile Leu Gln Gly Leu Gln Asp Ala Asn Gly Asn Tyr 
                165                 170                 175     


Thr Arg Gln Thr Asp Ile Leu Gln Ala Phe Ser Glu Glu Thr Lys Glu 
            180                 185                 190         


Gly Arg Leu Asp Ser Leu Thr Glu Val Asp Asp Ser Gly Gln Leu Thr 
        195                 200                 205             


Ile Lys Cys Ser Gln Asn Tyr Leu Ser Leu Asp Cys Gly Ile Thr Ala 
    210                 215                 220                 


Phe Glu Leu Ser Asp Tyr Ser Pro Ser Glu Asp Leu Leu Ser Gly Leu 
225                 230                 235                 240 


Gly Asp Met Thr Ser Ser Gln Val Lys Thr Lys Pro Phe Asp Ser Trp 
                245                 250                 255     


Ser Tyr Ser Glu Met Glu Lys Glu Phe Pro Glu Leu Ile Arg Ser Val 
            260                 265                 270         


Gly Leu Leu Thr Val Ala Ala Asp Ser Ile Ser Thr Asn Gly Ser Glu 
        275                 280                 285             


Ala Val Thr Glu Glu Val Ser Gln Val Ser Leu Ser Val Asp Asp Lys 
    290                 295                 300                 


Gly Gly Cys Glu Glu Asp Asn Ala Ser Ala Val Glu Glu Gln Pro Gly 
305                 310                 315                 320 


Leu Thr Leu Gly Val Ser Ser Ser Ser Gly Glu Ala Leu Thr Asn Ala 
                325                 330                 335     


Ala Gln Pro Ser Ser Glu Thr Val Gln Gln Glu Ser Ser Ser Ser Ser 
            340                 345                 350         


His His Asp Ala Lys Asn Gln Gln Pro Val Pro Cys Glu Asn Ala Thr 
        355                 360                 365             


Pro Lys Arg Thr Ile Arg Asp Cys Phe Asn Tyr Asn Glu Asp Ser Pro 
    370                 375                 380                 


Thr Gln Pro Thr Leu Pro Lys Arg Gly Leu Phe Leu Lys Glu Glu Thr 
385                 390                 395                 400 


Phe Lys Asn Asp Leu Lys Gly Asn Gly Gly Lys Arg Gln Met Val Asp 
                405                 410                 415     


Leu Lys Pro Glu Met Ser Arg Ser Thr Pro Ser Leu Val Asp Pro Pro 
            420                 425                 430         


Asp Arg Ser Lys Leu Cys Leu Val Leu Gln Ser Ser Tyr Pro Asn Ser 
        435                 440                 445             


Pro Ser Ala Ala Ser Gln Ser Tyr Glu Cys Leu His Lys Val Gly Asn 
    450                 455                 460                 


Gly Asn Leu Glu Asn Thr Val Lys Phe His Ile Lys Glu Ile Ser Ser 
465                 470                 475                 480 


Ser Leu Gly Arg Leu Asn Asp Cys Tyr Lys Glu Lys Ser Arg Leu Lys 
                485                 490                 495     


Lys Pro His Lys Thr Ser Glu Glu Val Pro Pro Cys Arg Thr Pro Lys 
            500                 505                 510         


Arg Gly Thr Gly Ser Gly Lys Gln Ala Lys Asn Thr Lys Ser Ser Ala 
        515                 520                 525             


Val Pro Asn Gly Glu Leu Ser Tyr Thr Ser Lys Ala Ile Glu Gly Pro 
    530                 535                 540                 


Gln Thr Asn Ser Ala Ser Thr Ser Ser Leu Glu Pro Cys Asn Gln Arg 
545                 550                 555                 560 


Ser Trp Asn Ala Lys Leu Gln Leu Gln Ser Glu Thr Ser Ser Ser Pro 
                565                 570                 575     


Ala Phe Thr Gln Ser Ser Glu Ser Ser Val Gly Ser Asp Asn Ile Met 
            580                 585                 590         


Ser Pro Val Pro Leu Leu Ser Lys His Lys Ser Lys Lys Gly Gln Ala 
        595                 600                 605             


Ser Ser Pro Ser His Val Thr Arg Asn Gly Glu Val Val Glu Ala Trp 
    610                 615                 620                 


Tyr Gly Ser Asp Glu Tyr Leu Ala Leu Pro Ser His Leu Lys Gln Thr 
625                 630                 635                 640 


Glu Val Leu Ala Leu Lys Leu Glu Asn Leu Thr Lys Leu Leu Pro Gln 
                645                 650                 655     


Lys Pro Arg Gly Glu Thr Ile Gln Asn Ile Asp Asp Trp Glu Leu Ser 
            660                 665                 670         


Glu Met Asn Ser Asp Ser Glu Ile Tyr Pro Thr Tyr His Val Lys Lys 
        675                 680                 685             


Lys His Thr Arg Leu Gly Arg Val Ser Pro Ser Ser Ser Ser Asp Ile 
    690                 695                 700                 


Ala Ser Ser Leu Gly Glu Ser Ile Glu Ser Gly Pro Leu Ser Asp Ile 
705                 710                 715                 720 


Leu Ser Asp Glu Glu Ser Ser Met Pro Leu Ala Gly Met Lys Lys Tyr 
                725                 730                 735     


Ala Asp Glu Lys Ser Glu Arg Ala Ser Ser Ser Glu Lys Asn Glu Ser 
            740                 745                 750         


His Ser Ala Thr Lys Ser Ala Leu Ile Gln Lys Leu Met Gln Asp Ile 
        755                 760                 765             


Gln His Gln Asp Asn Tyr Glu Ala Ile Trp Glu Lys Ile Glu Gly Phe 
    770                 775                 780                 


Val Asn Lys Leu Asp Glu Phe Ile Gln Trp Leu Asn Glu Ala Met Glu 
785                 790                 795                 800 


Thr Thr Glu Asn Trp Thr Pro Pro Lys Ala Glu Met Asp Asp Leu Lys 
                805                 810                 815     


Leu Tyr Leu Glu Thr His Leu Ser Phe Lys Leu Asn Val Asp Ser His 
            820                 825                 830         


Cys Ala Leu Lys Glu Ala Val Glu Glu Glu Gly His Gln Leu Leu Glu 
        835                 840                 845             


Leu Ile Ala Ser His Lys Ala Gly Leu Lys Asp Met Leu Arg Met Ile 
    850                 855                 860                 


Ala Ser Gln Trp Lys Glu Leu Gln Arg Gln Ile Lys Arg Gln His Ser 
865                 870                 875                 880 


Trp Ile Leu Arg Ala Leu Asp Thr Ile Lys Ala Glu Ile Leu Ala Thr 
                885                 890                 895     


Asp Val Ser Val Glu Asp Glu Glu Gly Thr Gly Ser Pro Lys Ala Glu 
            900                 905                 910         


Val Gln Leu Cys Tyr Leu Glu Ala Gln Arg Asp Ala Val Glu Gln Met 
        915                 920                 925             


Ser Leu Lys Leu Tyr Ser Glu Gln Tyr Thr Ser Ser Ser Lys Arg Lys 
    930                 935                 940                 


Glu Glu Phe Ala Asp Met Ser Lys Val His Ser Val Gly Ser Asn Gly 
945                 950                 955                 960 


Leu Leu Asp Phe Asp Ser Glu Tyr Gln Glu Leu Trp Asp Cys Leu Ile 
                965                 970                 975     


Asp Met Glu Ser Leu Val Met Asp Ser His Asp Leu Met Met Ser Glu 
            980                 985                 990         


Glu Gln Gln Gln His Leu Tyr Lys  Arg Tyr Ser Val Glu  Met Ser Ile 
        995                 1000                 1005             


Arg His  Leu Lys Lys Thr Glu  Leu Leu Ser Lys Val  Glu Ala Leu 
    1010                 1015                 1020             


Lys Lys  Gly Gly Val Leu Leu  Pro Asn Asp Leu Leu  Glu Lys Val 
    1025                 1030                 1035             


Asp Ser  Ile Asn Glu Lys Trp  Glu Leu Leu Gly Lys  Thr Leu Gly 
    1040                 1045                 1050             


Glu Lys  Ile Gln Asp Thr Met  Ala Gly His Ser Gly  Ser Ser Pro 
    1055                 1060                 1065             


Arg Asp  Leu Leu Ser Pro Glu  Ser Gly Ser Leu Val  Arg Gln Leu 
    1070                 1075                 1080             


Glu Val  Arg Ile Lys Glu Leu  Lys Gly Trp Leu Arg  Asp Thr Glu 
    1085                 1090                 1095             


Leu Phe  Ile Phe Asn Ser Cys  Leu Arg Gln Glu Lys  Glu Gly Thr 
    1100                 1105                 1110             


Met Asn  Thr Glu Lys Gln Leu  Gln Tyr Phe Lys Ser  Leu Cys Arg 
    1115                 1120                 1125             


Glu Ile  Lys Gln Arg Arg Arg  Gly Val Ala Ser Ile  Leu Arg Leu 
    1130                 1135                 1140             


Cys Gln  His Leu Leu Asp Asp  Arg Glu Thr Cys Asn  Leu Asn Ala 
    1145                 1150                 1155             


Asp His  Gln Pro Met Gln Leu  Ile Ile Val Asn Leu  Glu Arg Arg 
    1160                 1165                 1170             


Trp Glu  Ala Ile Val Met Gln  Ala Val Gln Trp Gln  Thr Arg Leu 
    1175                 1180                 1185             


Gln Lys  Lys Met Gly Lys Glu  Ser Glu Thr Leu Asn  Val Ile Asp 
    1190                 1195                 1200             


Pro Gly  Leu Met Asp Leu Asn  Gly Met Ser Glu Asp  Ala Leu Glu 
    1205                 1210                 1215             


Trp Asp  Glu Met Asp Ile Ser  Asn Lys Leu Ile Ser  Leu Asn Glu 
    1220                 1225                 1230             


Glu Ser  Asn Asp Leu Asp Gln  Glu Leu Gln Pro Val  Ile Pro Ser 
    1235                 1240                 1245             


Leu Lys  Leu Gly Glu Thr Ser  Asn Glu Asp Pro Gly  Tyr Asp Glu 
    1250                 1255                 1260             


Glu Ala  Asp Asn His Gly Gly  Ser Gln Tyr Ala Ser  Asn Ile Thr 
    1265                 1270                 1275             


Ala Pro  Ser Ser Pro His Ile  Tyr Gln Val Tyr Ser  Leu His Asn 
    1280                 1285                 1290             


Val Glu  Leu Tyr Glu Asp Asn  His Met Pro Phe Leu  Lys Asn Asn 
    1295                 1300                 1305             


Pro Lys  Val Thr Gly Met Thr  Gln Pro Asn Val Leu  Thr Lys Ser 
    1310                 1315                 1320             


Leu Ser  Lys Asp Ser Ser Phe  Ser Ser Thr Lys Ser  Leu Pro Asp 
    1325                 1330                 1335             


Leu Leu  Gly Gly Ser Asn Leu  Val Lys Pro Cys Ala  Cys His Gly 
    1340                 1345                 1350             


Gly Asp  Met Ser Gln Asn Ser  Gly Ser Glu Ser Gly  Ile Val Ser 
    1355                 1360                 1365             


Glu Gly  Asp Thr Glu Thr Thr  Thr Asn Ser Glu Met  Cys Leu Leu 
    1370                 1375                 1380             


Asn Ala  Val Asp Gly Ser Pro  Ser Asn Leu Glu Thr  Glu His Leu 
    1385                 1390                 1395             


Asp Pro  Gln Met Gly Asp Ala  Val Asn Val Leu Lys  Gln Lys Phe 
    1400                 1405                 1410             


Thr Asp  Glu Gly Glu Ser Ile  Lys Leu Pro Asn Ser  Ser Gln Ser 
    1415                 1420                 1425             


Ser Ile  Ser Pro Val Gly Cys  Val Asn Gly Lys Val  Gly Asp Leu 
    1430                 1435                 1440             


Asn Ser  Ile Thr Lys His Thr  Pro Asp Cys Leu Gly  Glu Glu Leu 
    1445                 1450                 1455             


Gln Gly  Lys His Asp Val Phe  Thr Phe Tyr Asp Tyr  Ser Tyr Leu 
    1460                 1465                 1470             


Gln Gly  Ser Lys Leu Lys Leu  Pro Met Ile Met Lys  Gln Ser Gln 
    1475                 1480                 1485             


Ser Glu  Lys Val His Val Glu  Asp Pro Leu Leu Arg  Gly Phe Tyr 
    1490                 1495                 1500             


Phe Asp  Lys Lys Ser Cys Lys  Ser Lys His Gln Thr  Thr Glu Leu 
    1505                 1510                 1515             


Gln Pro  Asp Val Pro Pro His  Glu Arg Ile Leu Ala  Ser Ala Ser 
    1520                 1525                 1530             


His Glu  Met Asp Arg Ile Ser  Tyr Lys Ser Gly Asn  Ile Glu Lys 
    1535                 1540                 1545             


Thr Phe  Thr Gly Met Gln Asn  Ala Lys Gln Leu Ser  Leu Leu Ser 
    1550                 1555                 1560             


His Ser  Ser Ser Ile Glu Ser  Leu Ser Pro Gly Gly  Asp Leu Phe 
    1565                 1570                 1575             


Gly Leu  Gly Ile Phe Lys Asn  Gly Ser Asp Ser Leu  Gln Arg Ser 
    1580                 1585                 1590             


Thr Ser  Leu Glu Ser Trp Leu  Thr Ser Tyr Lys Ser  Asn Glu Asp 
    1595                 1600                 1605             


Leu Phe  Ser Cys His Ser Ser  Gly Asp Ile Ser Val  Ser Ser Gly 
    1610                 1615                 1620             


Ser Val  Gly Glu Leu Ser Lys  Arg Thr Leu Asp Leu  Leu Asn Arg 
    1625                 1630                 1635             


Leu Glu  Asn Ile Gln Ser Pro  Ser Glu Gln Lys Ile  Lys Arg Ser 
    1640                 1645                 1650             


Val Ser  Asp Ile Thr Leu Gln  Ser Ser Ser Gln Lys  Met Ser Phe 
    1655                 1660                 1665             


Thr Gly  Gln Met Ser Leu Asp  Ile Ala Ser Ser Ile  Asn Glu Asp 
    1670                 1675                 1680             


Ser Ala  Ala Ser Leu Thr Glu  Leu Ser Ser Ser Asp  Glu Leu Ser 
    1685                 1690                 1695             


Leu Cys  Ser Glu Asp Ile Val  Leu His Lys Asn Lys  Ile Pro Glu 
    1700                 1705                 1710             


Ser Asn  Ala Ser Phe Arg Lys  Arg Leu Thr Arg Ser  Val Ala Asp 
    1715                 1720                 1725             


Glu Ser  Asp Val Asn Val Ser  Met Ile Val Asn Val  Ser Cys Thr 
    1730                 1735                 1740             


Ser Ala  Cys Thr Asp Asp Glu  Asp Asp Ser Asp Leu  Leu Ser Ser 
    1745                 1750                 1755             


Ser Thr  Leu Thr Leu Thr Glu  Glu Glu Leu Cys Ile  Lys Asp Glu 
    1760                 1765                 1770             


Asp Asp  Asp Ser Ser Ile Ala  Thr Asp Asp Glu Ile  Tyr Glu Asp 
    1775                 1780                 1785             


Cys Thr  Leu Met Ser Gly Leu  Asp Tyr Ile Lys Asn  Glu Leu Gln 
    1790                 1795                 1800             


Thr Trp  Ile Arg Pro Lys Leu  Ser Leu Thr Arg Asp  Lys Lys Arg 
    1805                 1810                 1815             


Cys Asn  Val Ser Asp Glu Met  Lys Gly Ser Lys Asp  Ile Ser Ser 
    1820                 1825                 1830             


Ser Glu  Met Thr Asn Pro Ser  Asp Thr Leu Asn Ile  Glu Thr Leu 
    1835                 1840                 1845             


Leu Asn  Gly Ser Val Lys Arg  Val Ser Glu Asn Asn  Gly Asn Gly 
    1850                 1855                 1860             


Lys Asn  Ser Ser His Thr His  Glu Leu Gly Thr Lys  Arg Glu Asn 
    1865                 1870                 1875             


Lys Lys  Thr Ile Phe Lys Val  Asn Lys Asp Pro Tyr  Val Ala Asp 
    1880                 1885                 1890             


Met Glu  Asn Gly Asn Ile Glu  Gly Ile Pro Glu Arg  Gln Lys Gly 
    1895                 1900                 1905             


Lys Pro  Asn Val Thr Ser Lys  Val Ser Glu Asn Leu  Gly Ser His 
    1910                 1915                 1920             


Gly Lys  Glu Ile Ser Glu Ser  Glu His Cys Lys Cys  Lys Ala Leu 
    1925                 1930                 1935             


Met Asp  Ser Leu Asp Asp Ser  Asn Thr Ala Gly Lys  Glu Phe Val 
    1940                 1945                 1950             


Ser Gln  Asp Val Arg His Leu  Pro Lys Lys Cys Pro  Asn His His 
    1955                 1960                 1965             


His Phe  Glu Asn Gln Ser Thr  Ala Ser Thr Pro Thr  Glu Lys Ser 
    1970                 1975                 1980             


Phe Ser  Glu Leu Ala Leu Glu  Thr Arg Phe Asn Asn  Arg Gln Asp 
    1985                 1990                 1995             


Ser Asp  Ala Leu Lys Ser Ser  Asp Asp Ala Pro Ser  Met Ala Gly 
    2000                 2005                 2010             


Lys Ser  Ala Gly Cys Cys Leu  Ala Leu Glu Gln Asn  Gly Thr Glu 
    2015                 2020                 2025             


Glu Asn  Ala Ser Ile Ser Asn  Ile Ser Cys Cys Asn  Cys Glu Pro 
    2030                 2035                 2040             


Asp Val  Phe His Gln Lys Asp  Ala Glu Asp Cys Ser  Val His Asn 
    2045                 2050                 2055             


Phe Val  Lys Glu Ile Ile Asp  Met Ala Ser Thr Ala  Leu Lys Ser 
    2060                 2065                 2070             


Lys Ser  Gln Pro Glu Asn Glu  Val Ala Ala Pro Thr  Ser Leu Thr 
    2075                 2080                 2085             


Gln Ile  Lys Glu Lys Val Leu  Glu His Ser His Arg  Pro Ile Gln 
    2090                 2095                 2100             


Leu Arg  Lys Gly Asp Phe Tyr  Ser Tyr Leu Ser Leu  Ser Ser His 
    2105                 2110                 2115             


Asp Ser  Asp Cys Gly Glu Val  Thr Asn Tyr Ile Glu  Glu Lys Ser 
    2120                 2125                 2130             


Ser Thr  Pro Leu Pro Leu Asp  Thr Thr Asp Ser Gly  Leu Asp Asp 
    2135                 2140                 2145             


Lys Glu  Asp Ile Glu Cys Phe  Phe Glu Ala Cys Val  Glu Gly Asp 
    2150                 2155                 2160             


Ser Asp  Gly Glu Glu Pro Cys  Phe Ser Ser Ala Pro  Pro Asn Glu 
    2165                 2170                 2175             


Ser Ala  Val Pro Ser Glu Ala  Ala Met Pro Leu Gln  Ala Thr Ala 
    2180                 2185                 2190             


Cys Ser  Ser Glu Phe Ser Asp  Ser Ser Leu Ser Ala  Asp Asp Ala 
    2195                 2200                 2205             


Asp Thr  Val Ala Leu Ser Ser  Pro Ser Ser Gln Glu  Arg Ala Glu 
    2210                 2215                 2220             


Val Gly  Lys Glu Val Asn Gly  Leu Pro Gln Thr Ser  Ser Gly Cys 
    2225                 2230                 2235             


Ala Glu  Asn Leu Glu Phe Thr  Pro Ser Lys Leu Asp  Ser Glu Lys 
    2240                 2245                 2250             


Glu Ser  Ser Gly Lys Pro Gly  Glu Ser Gly Met Pro  Glu Glu His 
    2255                 2260                 2265             


Asn Ala  Ala Ser Ala Lys Ser  Lys Val Gln Asp Leu  Ser Leu Lys 
    2270                 2275                 2280             


Ala Asn  Gln Pro Thr Asp Lys  Ala Ala Leu His Pro  Ser Pro Lys 
    2285                 2290                 2295             


Thr Leu  Thr Cys Glu Glu Asn  Leu Leu Asn Leu His  Glu Lys Arg 
    2300                 2305                 2310             


His Arg  Asn Met His Arg 
    2315                 


<210>  4
<211>  524
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(27)
<223>  Polyproline domain

<400>  4

Met Ala Ala Pro Glu Pro Ala Arg Ala Ala Pro Pro Pro Pro Pro Pro 
1               5                   10                  15      


Pro Pro Pro Pro Leu Gly Ala Asp Arg Val Val Lys Ala Val Pro Phe 
            20                  25                  30          


Pro Pro Thr His Arg Leu Thr Ser Glu Glu Val Phe Asp Met Asp Gly 
        35                  40                  45              


Ile Pro Arg Val Asp Val Leu Lys Asn His Leu Val Lys Glu Gly Arg 
    50                  55                  60                  


Val Asp Glu Glu Ile Ala Leu Arg Ile Ile Asn Glu Gly Ala Ala Ile 
65                  70                  75                  80  


Leu Arg Arg Glu Lys Thr Met Ile Glu Val Glu Ala Pro Ile Thr Val 
                85                  90                  95      


Cys Gly Asp Ile His Gly Gln Phe Phe Asp Leu Met Lys Leu Phe Glu 
            100                 105                 110         


Val Gly Gly Ser Pro Ala Asn Thr Arg Tyr Leu Phe Leu Gly Asp Tyr 
        115                 120                 125             


Val Asp Arg Gly Tyr Phe Ser Ile Glu Cys Val Leu Tyr Leu Trp Val 
    130                 135                 140                 


Leu Lys Ile Leu Tyr Pro Ser Thr Leu Phe Leu Leu Arg Gly Asn His 
145                 150                 155                 160 


Glu Cys Arg His Leu Thr Glu Tyr Phe Thr Phe Lys Gln Glu Cys Lys 
                165                 170                 175     


Ile Lys Tyr Ser Glu Arg Val Tyr Glu Ala Cys Met Glu Ala Phe Asp 
            180                 185                 190         


Ser Leu Pro Leu Ala Ala Leu Leu Asn Gln Gln Phe Leu Cys Val His 
        195                 200                 205             


Gly Gly Leu Ser Pro Glu Ile His Thr Leu Asp Asp Ile Arg Arg Leu 
    210                 215                 220                 


Asp Arg Phe Lys Glu Pro Pro Ala Phe Gly Pro Met Cys Asp Leu Leu 
225                 230                 235                 240 


Trp Ser Asp Pro Ser Glu Asp Phe Gly Asn Glu Lys Ser Gln Glu His 
                245                 250                 255     


Phe Ser His Asn Thr Val Arg Gly Cys Ser Tyr Phe Tyr Asn Tyr Pro 
            260                 265                 270         


Ala Val Cys Glu Phe Leu Gln Asn Asn Asn Leu Leu Ser Ile Ile Arg 
        275                 280                 285             


Ala His Glu Ala Gln Asp Ala Gly Tyr Arg Met Tyr Arg Lys Ser Gln 
    290                 295                 300                 


Thr Thr Gly Phe Pro Ser Leu Ile Thr Ile Phe Ser Ala Pro Asn Tyr 
305                 310                 315                 320 


Leu Asp Val Tyr Asn Asn Lys Ala Ala Val Leu Lys Tyr Glu Asn Asn 
                325                 330                 335     


Val Met Asn Ile Arg Gln Phe Asn Cys Ser Pro His Pro Tyr Trp Leu 
            340                 345                 350         


Pro Asn Phe Met Asp Val Phe Thr Trp Ser Leu Pro Phe Val Gly Glu 
        355                 360                 365             


Lys Val Thr Glu Met Leu Val Asn Val Leu Ser Ile Cys Ser Asp Asp 
    370                 375                 380                 


Glu Leu Met Thr Glu Gly Glu Asp Gln Phe Asp Gly Ser Ala Ala Ala 
385                 390                 395                 400 


Arg Lys Glu Ile Ile Arg Asn Lys Ile Arg Ala Ile Gly Lys Met Ala 
                405                 410                 415     


Arg Val Phe Ser Val Leu Arg Glu Glu Ser Glu Ser Val Leu Thr Leu 
            420                 425                 430         


Lys Gly Leu Thr Pro Thr Gly Met Leu Pro Ser Gly Val Leu Ala Gly 
        435                 440                 445             


Gly Arg Gln Thr Leu Gln Ser Ala Thr Val Glu Ala Ile Glu Ala Glu 
    450                 455                 460                 


Lys Ala Ile Arg Gly Phe Ser Pro Pro His Arg Ile Cys Ser Phe Glu 
465                 470                 475                 480 


Glu Ala Lys Gly Leu Asp Arg Ile Asn Glu Arg Met Pro Pro Arg Lys 
                485                 490                 495     


Asp Ala Val Gln Gln Asp Gly Phe Asn Ser Leu Asn Thr Ala His Thr 
            500                 505                 510         


Thr Glu Asn His Gly Thr Gly Asn His Ser Ala Gln 
        515                 520                 


<210>  5
<211>  2314
<212>  PRT
<213>  Rattus rattus


<220>
<221>  MISC_FEATURE
<222>  (1286)..(1345)
<223>  Calcineurin binding domain

<400>  5

Met Leu Thr Met Ser Val Thr Leu Ser Pro Leu Arg Ser Gln Gly Pro 
1               5                   10                  15      


Asp Pro Met Ala Thr Asp Ala Ser Pro Met Ala Ile Asn Met Thr Pro 
            20                  25                  30          


Thr Val Glu Gln Glu Glu Gly Glu Gly Glu Glu Ala Val Lys Ala Ile 
        35                  40                  45              


Asp Ala Glu Gln Gln Tyr Gly Lys Pro Pro Pro Leu His Thr Ala Ala 
    50                  55                  60                  


Asp Trp Lys Ile Val Leu His Leu Pro Glu Ile Glu Thr Trp Leu Arg 
65                  70                  75                  80  


Met Thr Ser Glu Arg Val Arg Asp Leu Thr Tyr Ser Val Gln Gln Asp 
                85                  90                  95      


Ala Asp Ser Lys His Val Asp Val His Leu Val Gln Leu Lys Asp Ile 
            100                 105                 110         


Cys Glu Asp Ile Ser Asp His Val Glu Gln Ile His Ala Leu Leu Glu 
        115                 120                 125             


Thr Glu Phe Ser Leu Lys Leu Leu Ser Tyr Ser Val Asn Val Ile Val 
    130                 135                 140                 


Asp Ile His Ala Val Gln Leu Leu Trp His Gln Leu Arg Val Ser Val 
145                 150                 155                 160 


Leu Val Leu Arg Glu Arg Ile Leu Gln Gly Leu Gln Asp Ala Asn Gly 
                165                 170                 175     


Asn Tyr Thr Arg Gln Thr Asp Ile Leu Gln Ala Phe Ser Glu Glu Thr 
            180                 185                 190         


Thr Glu Gly Arg Leu Asp Ser Leu Thr Glu Val Asp Asp Ser Gly Gln 
        195                 200                 205             


Leu Thr Ile Lys Cys Ser Gln Asp Tyr Leu Ser Leu Asp Cys Gly Ile 
    210                 215                 220                 


Thr Ala Phe Glu Leu Ser Asp Tyr Ser Pro Ser Glu Asp Leu Leu Gly 
225                 230                 235                 240 


Gly Leu Gly Asp Met Thr Thr Ser Gln Ala Lys Thr Lys Ser Phe Asp 
                245                 250                 255     


Ser Trp Ser Tyr Ser Glu Met Glu Lys Glu Phe Pro Glu Leu Ile Arg 
            260                 265                 270         


Ser Val Gly Leu Leu Thr Val Ala Thr Glu Pro Val Pro Ser Ser Cys 
        275                 280                 285             


Gly Glu Ala Asn Glu Asp Ser Ser Gln Ala Ser Leu Ser Asp Asp His 
    290                 295                 300                 


Lys Gly Glu His Gly Glu Asp Gly Ala Pro Val Pro Gly Gln Gln Leu 
305                 310                 315                 320 


Asp Ser Thr Val Gly Met Ser Ser Leu Asp Gly Thr Leu Ala Asn Ala 
                325                 330                 335     


Ala Glu His Pro Ser Glu Thr Ala Lys Gln Asp Ser Thr Ser Ser Pro 
            340                 345                 350         


Gln Leu Gly Ala Lys Lys Thr Gln Pro Gly Pro Cys Glu Ile Thr Thr 
        355                 360                 365             


Pro Lys Arg Ser Ile Arg Asp Cys Phe Asn Tyr Asn Glu Asp Ser Pro 
    370                 375                 380                 


Thr Gln Pro Thr Leu Pro Lys Arg Gly Leu Phe Leu Lys Glu Thr Gln 
385                 390                 395                 400 


Lys Asn Glu Arg Lys Gly Ser Asp Arg Lys Gly Gln Val Val Asp Leu 
                405                 410                 415     


Lys Pro Glu Leu Ser Arg Ser Thr Pro Ser Leu Val Asp Pro Pro Asp 
            420                 425                 430         


Arg Ser Lys Leu Cys Leu Val Leu Gln Ser Ser Tyr Pro Ser Ser Pro 
        435                 440                 445             


Ser Ala Ala Ser Gln Ser Tyr Glu Cys Leu His Lys Val Gly Leu Gly 
    450                 455                 460                 


Asn Leu Glu Asn Ile Val Arg Ser His Ile Lys Glu Ile Ser Ser Ser 
465                 470                 475                 480 


Leu Gly Arg Leu Thr Asp Cys His Lys Glu Lys Leu Arg Leu Lys Lys 
                485                 490                 495     


Pro His Lys Thr Leu Ala Glu Val Ser Leu Cys Arg Ile Pro Lys Gln 
            500                 505                 510         


Gly Gly Gly Ser Gly Lys Arg Ser Glu Ser Thr Gly Ser Ser Ala Gly 
        515                 520                 525             


Pro Ser Met Val Ser Pro Gly Ala Pro Lys Ala Thr Met Arg Pro Glu 
    530                 535                 540                 


Thr Asp Ser Ala Ser Thr Ala Ser Gly Gly Leu Cys His Gln Arg Asn 
545                 550                 555                 560 


Arg Ser Gly Gln Leu Pro Val Gln Ser Lys Ala Ser Ser Ser Pro Pro 
                565                 570                 575     


Cys Ser His Ser Ser Glu Ser Ser Leu Gly Ser Asp Ser Ile Lys Ser 
            580                 585                 590         


Pro Val Pro Leu Leu Ser Lys Asn Lys Ser Gln Lys Ser Ser Pro Pro 
        595                 600                 605             


Ala Pro Cys His Ala Thr Gln Asn Gly Gln Val Val Glu Ala Trp Tyr 
    610                 615                 620                 


Gly Ser Asp Glu Tyr Leu Ala Leu Pro Ser His Leu Lys Gln Thr Glu 
625                 630                 635                 640 


Val Leu Ala Leu Lys Leu Glu Ser Leu Thr Lys Leu Leu Pro Gln Lys 
                645                 650                 655     


Pro Arg Gly Glu Thr Ile Gln Asp Ile Asp Asp Trp Glu Leu Ser Glu 
            660                 665                 670         


Met Asn Ser Asp Ser Glu Ile Tyr Pro Thr Tyr His Ile Lys Lys Lys 
        675                 680                 685             


His Thr Arg Leu Gly Thr Val Ser Pro Ser Ser Ser Ser Asp Ile Ala 
    690                 695                 700                 


Ser Ser Leu Gly Glu Ser Ile Glu Ser Gly Pro Leu Ser Asp Ile Leu 
705                 710                 715                 720 


Ser Asp Glu Asp Leu Cys Leu Pro Leu Ser Ser Val Lys Lys Phe Thr 
                725                 730                 735     


Asp Glu Lys Ser Glu Arg Pro Ser Ser Ser Glu Lys Asn Glu Ser His 
            740                 745                 750         


Ser Ala Thr Arg Ser Ala Leu Ile Gln Lys Leu Met His Asp Ile Gln 
        755                 760                 765             


His Gln Glu Asn Tyr Glu Ala Ile Trp Glu Arg Ile Glu Gly Phe Val 
    770                 775                 780                 


Asn Lys Leu Asp Glu Phe Ile Gln Trp Leu Asn Glu Ala Met Glu Thr 
785                 790                 795                 800 


Thr Glu Asn Trp Thr Pro Pro Lys Ala Glu Thr Asp Ser Leu Arg Leu 
                805                 810                 815     


Tyr Leu Glu Thr His Leu Ser Phe Lys Leu Asn Val Asp Ser His Cys 
            820                 825                 830         


Ala Leu Lys Glu Ala Val Glu Glu Glu Gly His Gln Leu Leu Glu Leu 
        835                 840                 845             


Val Val Ser His Lys Ala Gly Leu Lys Asp Thr Leu Arg Met Ile Ala 
    850                 855                 860                 


Ser Gln Trp Lys Glu Leu Gln Arg Gln Ile Lys Arg Gln His Ser Trp 
865                 870                 875                 880 


Ile Leu Arg Ala Leu Asp Thr Ile Lys Ala Glu Ile Leu Ala Thr Asp 
                885                 890                 895     


Val Ser Val Glu Asp Glu Glu Gly Thr Gly Ser Pro Lys Ala Glu Val 
            900                 905                 910         


Gln Leu Cys His Leu Glu Thr Gln Arg Asp Ala Val Glu Gln Met Ser 
        915                 920                 925             


Leu Lys Leu Tyr Ser Glu Gln Tyr Thr Ser Gly Ser Lys Arg Lys Glu 
    930                 935                 940                 


Glu Phe Ala Asn Met Ser Lys Ala His Ala Glu Gly Ser Asn Gly Leu 
945                 950                 955                 960 


Leu Asp Phe Asp Ser Glu Tyr Gln Glu Leu Trp Asp Trp Leu Ile Asp 
                965                 970                 975     


Met Glu Ser Leu Val Met Asp Ser His Asp Leu Met Met Ser Glu Glu 
            980                 985                 990         


Gln Gln Gln His Leu Tyr Lys Arg  Tyr Ser Val Glu Met  Ser Ile Arg 
        995                 1000                 1005             


His Leu  Lys Lys Ser Glu Leu  Leu Ser Lys Val Glu  Ala Leu Lys 
    1010                 1015                 1020             


Lys Gly  Gly Leu Ser Leu Pro  Asp Asp Ile Leu Glu  Lys Val Asp 
    1025                 1030                 1035             


Ser Ile  Asn Glu Lys Trp Glu  Leu Leu Gly Lys Thr  Leu Arg Glu 
    1040                 1045                 1050             


Lys Ile  Gln Asp Thr Ile Ala  Gly His Ser Gly Ser  Gly Pro Arg 
    1055                 1060                 1065             


Asp Leu  Leu Ser Pro Glu Ser  Gly Ser Leu Val Arg  Gln Leu Glu 
    1070                 1075                 1080             


Val Arg  Ile Lys Glu Leu Lys  Arg Trp Leu Arg Asp  Thr Glu Leu 
    1085                 1090                 1095             


Phe Ile  Phe Asn Ser Cys Leu  Arg Gln Glu Lys Glu  Gly Thr Ser 
    1100                 1105                 1110             


Ala Glu  Lys Gln Leu Gln Tyr  Phe Lys Ser Leu Cys  Arg Glu Ile 
    1115                 1120                 1125             


Lys Gln  Arg Arg Arg Gly Val  Ala Ser Ile Leu Arg  Leu Cys Gln 
    1130                 1135                 1140             


His Leu  Leu Asp Asp Arg Asp  Thr Cys Asn Leu Asn  Ala Asp His 
    1145                 1150                 1155             


Gln Pro  Met Gln Leu Ile Ile  Val Asn Leu Glu Arg  Arg Trp Glu 
    1160                 1165                 1170             


Ala Ile  Val Met Gln Ala Val  Gln Trp Gln Thr Arg  Leu Gln Lys 
    1175                 1180                 1185             


Lys Met  Gly Lys Glu Ser Glu  Thr Leu Asn Val Ile  Asp Pro Gly 
    1190                 1195                 1200             


Leu Met  Asp Leu Asn Gly Met  Ser Glu Asp Ala Leu  Glu Trp Asp 
    1205                 1210                 1215             


Glu Thr  Asp Ile Ser Asn Lys  Leu Ile Ser Val His  Glu Glu Ser 
    1220                 1225                 1230             


Asn Asp  Leu Asp Gln Asp Pro  Glu Pro Met Leu Pro  Ala Val Lys 
    1235                 1240                 1245             


Leu Glu  Glu Thr His His Lys  Asp Ser Gly Tyr Glu  Glu Glu Ala 
    1250                 1255                 1260             


Gly Asp  Cys Gly Gly Ser Pro  Tyr Thr Ser Asn Ile  Thr Ala Pro 
    1265                 1270                 1275             


Ser Ser  Pro His Ile Tyr Gln  Val Tyr Ser Leu His  Asn Val Glu 
    1280                 1285                 1290             


Leu His  Glu Asp Ser His Thr  Pro Phe Leu Lys Ser  Ser Pro Lys 
    1295                 1300                 1305             


Phe Thr  Gly Thr Thr Gln Pro  Thr Val Leu Thr Lys  Ser Leu Ser 
    1310                 1315                 1320             


Lys Asp  Ser Ser Phe Ser Ser  Thr Lys Ser Leu Pro  Asp Leu Leu 
    1325                 1330                 1335             


Gly Gly  Ser Gly Leu Val Arg  Pro Tyr Ser Cys His  Ser Gly Asp 
    1340                 1345                 1350             


Leu Ser  Gln Asn Ser Gly Ser  Glu Ser Gly Ile Val  Ser Glu Gly 
    1355                 1360                 1365             


Asp Asn  Glu Met Pro Thr Asn  Ser Asp Met Ser Leu  Phe Ser Met 
    1370                 1375                 1380             


Val Asp  Gly Ser Pro Ser Asn  Pro Glu Thr Glu His  Pro Asp Pro 
    1385                 1390                 1395             


Gln Met  Gly Asp Ala Ala Asn  Val Leu Glu Gln Lys  Phe Lys Asp 
    1400                 1405                 1410             


Asn Gly  Glu Ser Ile Lys Leu  Ser Ser Val Ser Arg  Ala Ser Val 
    1415                 1420                 1425             


Ser Pro  Val Gly Cys Val Asn  Gly Lys Ala Gly Asp  Leu Asn Ser 
    1430                 1435                 1440             


Val Thr  Lys His Thr Ala Asp  Cys Leu Gly Glu Glu  Leu Gln Gly 
    1445                 1450                 1455             


Lys His  Asp Val Phe Thr Phe  Tyr Asp Tyr Ser Tyr  Leu Gln Gly 
    1460                 1465                 1470             


Ser Lys  Leu Lys Leu Pro Met  Ile Met Lys Gln Pro  Gln Ser Glu 
    1475                 1480                 1485             


Lys Ala  His Val Glu Asp Pro  Leu Leu Gly Gly Phe  Tyr Phe Asp 
    1490                 1495                 1500             


Lys Lys  Ser Cys Lys Ala Lys  His Gln Ala Ser Glu  Ser Gln Pro 
    1505                 1510                 1515             


Asp Ala  Pro Pro His Glu Arg  Ile Leu Ala Ser Ala  Pro His Glu 
    1520                 1525                 1530             


Met Gly  Arg Ser Ala Tyr Lys  Ser Ser Asp Ile Glu  Lys Thr Phe 
    1535                 1540                 1545             


Thr Gly  Ile Gln Ser Ala Arg  Gln Leu Ser Leu Leu  Ser Arg Ser 
    1550                 1555                 1560             


Ser Ser  Val Glu Ser Leu Ser  Pro Gly Gly Asp Leu  Phe Gly Leu 
    1565                 1570                 1575             


Gly Ile  Phe Lys Asn Gly Ser  Asp Ser Leu Gln Arg  Ser Thr Ser 
    1580                 1585                 1590             


Leu Glu  Ser Trp Leu Thr Ser  Tyr Lys Ser Asn Glu  Asp Leu Phe 
    1595                 1600                 1605             


Ser Cys  His Ser Ser Gly Asp  Ile Ser Val Ser Ser  Gly Ser Val 
    1610                 1615                 1620             


Gly Glu  Leu Ser Lys Arg Thr  Leu Asp Leu Leu Asn  Arg Leu Glu 
    1625                 1630                 1635             


Asn Ile  Gln Ser Pro Ser Glu  Gln Lys Ile Lys Arg  Ser Val Ser 
    1640                 1645                 1650             


Asp Met  Thr Leu Gln Ser Ser  Ser Gln Lys Met Pro  Phe Ala Gly 
    1655                 1660                 1665             


Gln Met  Ser Leu Asp Val Ala  Ser Ser Ile Asn Glu  Asp Ser Pro 
    1670                 1675                 1680             


Ala Ser  Leu Thr Glu Leu Ser  Ser Ser Asp Glu Leu  Ser Leu Cys 
    1685                 1690                 1695             


Ser Glu  Asp Ile Val Leu His  Lys Asn Lys Ile Pro  Glu Ser Asn 
    1700                 1705                 1710             


Ala Ser  Phe Arg Lys Arg Leu  Asn Arg Ser Val Ala  Asp Glu Ser 
    1715                 1720                 1725             


Asp Val  Asn Val Ser Met Ile  Val Asn Val Ser Cys  Thr Ser Ala 
    1730                 1735                 1740             


Cys Thr  Asp Asp Glu Asp Asp  Ser Asp Leu Leu Ser  Ser Ser Thr 
    1745                 1750                 1755             


Leu Thr  Leu Thr Glu Glu Glu  Leu Cys Leu Lys Asp  Glu Asp Asp 
    1760                 1765                 1770             


Asp Ser  Ser Ile Ala Thr Asp  Asp Glu Ile Tyr Glu  Glu Ser Asn 
    1775                 1780                 1785             


Leu Met  Ser Gly Leu Asp Tyr  Ile Lys Asn Glu Leu  Gln Thr Trp 
    1790                 1795                 1800             


Ile Arg  Pro Lys Leu Ser Leu  Thr Arg Glu Lys Lys  Arg Ser Gly 
    1805                 1810                 1815             


Val Thr  Asp Glu Ile Lys Val  Asn Lys Asp Gly Gly  Gly Asn Glu 
    1820                 1825                 1830             


Lys Ala  Asn Pro Ser Asp Thr  Leu Asp Ile Glu Ala  Leu Leu Asn 
    1835                 1840                 1845             


Gly Ser  Ile Arg Cys Leu Ser  Glu Asn Asn Gly Asn  Gly Lys Thr 
    1850                 1855                 1860             


Pro Pro  Arg Thr His Gly Ser  Gly Thr Lys Gly Glu  Asn Lys Lys 
    1865                 1870                 1875             


Ser Thr  Tyr Asp Val Ser Lys  Asp Pro His Val Ala  Asp Met Glu 
    1880                 1885                 1890             


Asn Gly  Asn Ile Glu Ser Thr  Pro Glu Arg Glu Arg  Glu Lys Pro 
    1895                 1900                 1905             


Gln Gly  Leu Pro Glu Val Ser  Glu Asn Leu Ala Ser  Asn Val Lys 
    1910                 1915                 1920             


Thr Ile  Ser Glu Ser Glu Leu  Ser Glu Tyr Glu Ala  Val Met Asp 
    1925                 1930                 1935             


Gly Ser  Glu Asp Ser Ser Val  Ala Arg Lys Glu Phe  Cys Pro Pro 
    1940                 1945                 1950             


Asn Asp  Arg His Pro Pro Gln  Met Gly Pro Lys Leu  Gln His Pro 
    1955                 1960                 1965             


Glu Asn  Gln Ser Gly Asp Cys  Lys Pro Val Gln Asn  Pro Cys Pro 
    1970                 1975                 1980             


Gly Leu  Leu Ser Glu Ala Gly  Val Gly Ser Arg Gln  Asp Ser Asn 
    1985                 1990                 1995             


Gly Leu  Lys Ser Leu Pro Asn  Asp Ala Pro Ser Gly  Ala Arg Lys 
    2000                 2005                 2010             


Pro Ala  Gly Cys Cys Leu Leu  Glu Gln Asn Glu Thr  Glu Glu Ser 
    2015                 2020                 2025             


Ala Ser  Ile Ser Ser Asn Ala  Ser Cys Cys Asn Cys  Lys Pro Asp 
    2030                 2035                 2040             


Val Phe  His Gln Lys Asp Asp  Glu Asp Cys Ser Val  His Asp Phe 
    2045                 2050                 2055             


Val Lys  Glu Ile Ile Asp Met  Ala Ser Thr Ala Leu  Lys Ser Lys 
    2060                 2065                 2070             


Ser Gln  Pro Glu Ser Glu Val  Ala Ala Pro Thr Ser  Leu Thr Gln 
    2075                 2080                 2085             


Ile Lys  Glu Lys Val Leu Glu  His Ser His Arg Pro  Ile His Leu 
    2090                 2095                 2100             


Arg Lys  Gly Asp Phe Tyr Ser  Tyr Leu Ser Leu Ser  Ser His Asp 
    2105                 2110                 2115             


Ser Asp  Cys Gly Glu Val Thr  Asn Tyr Ile Asp Glu  Lys Ser Ser 
    2120                 2125                 2130             


Thr Pro  Leu Pro Pro Asp Ala  Val Asp Ser Gly Leu  Asp Asp Lys 
    2135                 2140                 2145             


Glu Asp  Met Asp Cys Phe Phe  Glu Ala Cys Val Glu  Asp Glu Pro 
    2150                 2155                 2160             


Val Asn  Glu Glu Ala Gly Leu  Pro Gly Ala Leu Pro  Asn Glu Ser 
    2165                 2170                 2175             


Ala Ile  Glu Asp Gly Ala Glu  Gln Lys Ser Glu Gln  Lys Thr Ala 
    2180                 2185                 2190             


Ser Ser  Pro Val Leu Ser Asp  Lys Thr Asp Leu Val  Pro Leu Ser 
    2195                 2200                 2205             


Gly Leu  Ser Pro Gln Lys Gly  Ala Asp Asp Ala Lys  Glu Gly Asp 
    2210                 2215                 2220             


Asp Val  Ser His Thr Ser Gln  Gly Cys Ala Glu Ser  Thr Glu Pro 
    2225                 2230                 2235             


Thr Thr  Pro Ser Gly Lys Ala  Asn Ala Glu Gly Arg  Ser Arg Met 
    2240                 2245                 2250             


Gln Gly  Val Ser Ala Thr Pro  Glu Glu Asn Ala Ala  Ser Ala Lys 
    2255                 2260                 2265             


Pro Lys  Ile Gln Ala Phe Ser  Leu Asn Ala Lys Gln  Pro Lys Gly 
    2270                 2275                 2280             


Lys Val  Ala Met Arg Tyr Pro  Ser Pro Gln Thr Leu  Thr Cys Lys 
    2285                 2290                 2295             


Glu Lys  Leu Val Asn Phe His  Glu Asp Arg His Ser  Asn Met His 
    2300                 2305                 2310             


Arg 
    


