                         SEQUENCE LISTING

<110>  Merial, Inc.
       Audonnet, Jean-Christophe
       Reynard , Frederic
       Bomchil, Natalia
       Sigoillot-Claude , Cecile
 
<120>  FMDV and E2 Fusion Proteins and Uses Thereof

<130>  MER 15-283.PCT

<150>  62/259,043
<151>  2015-11-23

<160>  15    

<170>  PatentIn version 3.5

<210>  1
<211>  246
<212>  DNA
<213>  artificial sequence

<220>
<223>  Polynucleotide encoding synthetic FMDV antigen corresponding to 
       VP1 of FMDV O1 Manisa strain

<400>  1
atggaaaatt atggtggtga aacccaggtt cagcgtcgtc agcataccga tgttagcttt       60

attctggatc gttttgttaa agtgaccccg tataatggca atagcaaata tggtgatggc      120

accgttgcaa atgttcgtgg tgatctgcag gttctggcac agaaagcagc acgtgcactg      180

ccgaccagtc cggatcaggc acgtcataaa cagaaaattg ttgcaccggt taaacagctg      240

ctgtaa                                                                 246


<210>  2
<211>  81
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic FMDV antigen corresponding to VP1 of FMDV O1 Manisa 
       strain

<400>  2

Met Glu Asn Tyr Gly Gly Glu Thr Gln Val Gln Arg Arg Gln His Thr 
1               5                   10                  15      


Asp Val Ser Phe Ile Leu Asp Arg Phe Val Lys Val Thr Pro Tyr Asn 
            20                  25                  30          


Gly Asn Ser Lys Tyr Gly Asp Gly Thr Val Ala Asn Val Arg Gly Asp 
        35                  40                  45              


Leu Gln Val Leu Ala Gln Lys Ala Ala Arg Ala Leu Pro Thr Ser Pro 
    50                  55                  60                  


Asp Gln Ala Arg His Lys Gln Lys Ile Val Ala Pro Val Lys Gln Leu 
65                  70                  75                  80  


Leu 
    


<210>  3
<211>  768
<212>  DNA
<213>  artificial sequence

<220>
<223>  Polynucleotide sequence for Linker and Core C terminal catalytic 
       domain of E2 from Geobacillus stearothermophilus

<400>  3
aagcttgcag cagcagaaga aaaagcagca ccggcagcag caaaaccggc aaccaccgaa       60

ggtgaatttc cggaaacccg tgaaaaaatg agcggtattc gtcgtgcaat tgcaaaagca      120

atggttcata gcaaacatac cgcaccgcat gttaccctga tggatgaagc agatgttacc      180

aaactggttg cccaccgcaa aaaattcaaa gcaattgcag cagagaaagg cattaaactg      240

acctttctgc cgtatgttgt taaagcactg gttagcgcac tgcgtgaata tccggttctg      300

aataccagca ttgatgatga aaccgaagag atcatccaga aacactatta caatattggc      360

attgcagcag ataccgatcg tggtctgctg gttccggtta ttaaacatgc agatcgtaaa      420

ccgatttttg cactggccca agaaattaat gaactggcag aaaaagcacg tgatggtaaa      480

ctgacaccgg gtgaaatgaa aggtgcaagc tgtaccatta caaatattgg tagtgccggt      540

ggtcagtggt ttacaccggt tattaatcat ccggaagttg ccattctggg tattggtcgt      600

attgcagaaa aaccgattgt tcgtgatggt gaaattgttg cagcaccgat gctggcactg      660

agcctgagct ttgatcatcg tatgattgat ggtgcaaccg cacagaaagc actgaatcat      720

attaaacgtc tgctgagcga tccggaactg ctgctgatgg aagcatga                   768


<210>  4
<211>  255
<212>  PRT
<213>  artificial sequence

<220>
<223>  protein sequence for Linker and Core C terminal catalytic domain 
       of E2 from Geobacillus stearothermophilus

<400>  4

Lys Leu Ala Ala Ala Glu Glu Lys Ala Ala Pro Ala Ala Ala Lys Pro 
1               5                   10                  15      


Ala Thr Thr Glu Gly Glu Phe Pro Glu Thr Arg Glu Lys Met Ser Gly 
            20                  25                  30          


Ile Arg Arg Ala Ile Ala Lys Ala Met Val His Ser Lys His Thr Ala 
        35                  40                  45              


Pro His Val Thr Leu Met Asp Glu Ala Asp Val Thr Lys Leu Val Ala 
    50                  55                  60                  


His Arg Lys Lys Phe Lys Ala Ile Ala Ala Glu Lys Gly Ile Lys Leu 
65                  70                  75                  80  


Thr Phe Leu Pro Tyr Val Val Lys Ala Leu Val Ser Ala Leu Arg Glu 
                85                  90                  95      


Tyr Pro Val Leu Asn Thr Ser Ile Asp Asp Glu Thr Glu Glu Ile Ile 
            100                 105                 110         


Gln Lys His Tyr Tyr Asn Ile Gly Ile Ala Ala Asp Thr Asp Arg Gly 
        115                 120                 125             


Leu Leu Val Pro Val Ile Lys His Ala Asp Arg Lys Pro Ile Phe Ala 
    130                 135                 140                 


Leu Ala Gln Glu Ile Asn Glu Leu Ala Glu Lys Ala Arg Asp Gly Lys 
145                 150                 155                 160 


Leu Thr Pro Gly Glu Met Lys Gly Ala Ser Cys Thr Ile Thr Asn Ile 
                165                 170                 175     


Gly Ser Ala Gly Gly Gln Trp Phe Thr Pro Val Ile Asn His Pro Glu 
            180                 185                 190         


Val Ala Ile Leu Gly Ile Gly Arg Ile Ala Glu Lys Pro Ile Val Arg 
        195                 200                 205             


Asp Gly Glu Ile Val Ala Ala Pro Met Leu Ala Leu Ser Leu Ser Phe 
    210                 215                 220                 


Asp His Arg Met Ile Asp Gly Ala Thr Ala Gln Lys Ala Leu Asn His 
225                 230                 235                 240 


Ile Lys Arg Leu Leu Ser Asp Pro Glu Leu Leu Leu Met Glu Ala 
                245                 250                 255 


<210>  5
<211>  1011
<212>  DNA
<213>  artificial sequence

<220>
<223>  Polynucleotide encoding FMDV-E2 fusion protein

<400>  5
atggaaaatt atggtggtga aacccaggtt cagcgtcgtc agcataccga tgttagcttt       60

attctggatc gttttgttaa agtgaccccg tataatggca atagcaaata tggtgatggc      120

accgttgcaa atgttcgtgg tgatctgcag gttctggcac agaaagcagc acgtgcactg      180

ccgaccagtc cggatcaggc acgtcataaa cagaaaattg ttgcaccggt taaacagctg      240

ctgaagcttg cagcagcaga agaaaaagca gcaccggcag cagcaaaacc ggcaaccacc      300

gaaggtgaat ttccggaaac ccgtgaaaaa atgagcggta ttcgtcgtgc aattgcaaaa      360

gcaatggttc atagcaaaca taccgcaccg catgttaccc tgatggatga agcagatgtt      420

accaaactgg ttgcccaccg caaaaaattc aaagcaattg cagcagagaa aggcattaaa      480

ctgacctttc tgccgtatgt tgttaaagca ctggttagcg cactgcgtga atatccggtt      540

ctgaatacca gcattgatga tgaaaccgaa gagatcatcc agaaacacta ttacaatatt      600

ggcattgcag cagataccga tcgtggtctg ctggttccgg ttattaaaca tgcagatcgt      660

aaaccgattt ttgcactggc ccaagaaatt aatgaactgg cagaaaaagc acgtgatggt      720

aaactgacac cgggtgaaat gaaaggtgca agctgtacca ttacaaatat tggtagtgcc      780

ggtggtcagt ggtttacacc ggttattaat catccggaag ttgccattct gggtattggt      840

cgtattgcag aaaaaccgat tgttcgtgat ggtgaaattg ttgcagcacc gatgctggca      900

ctgagcctga gctttgatca tcgtatgatt gatggtgcaa ccgcacagaa agcactgaat      960

catattaaac gtctgctgag cgatccggaa ctgctgctga tggaagcatg a              1011


<210>  6
<211>  336
<212>  PRT
<213>  artificial sequence

<220>
<223>  FMDV-E2 fusion protein sequence

<400>  6

Met Glu Asn Tyr Gly Gly Glu Thr Gln Val Gln Arg Arg Gln His Thr 
1               5                   10                  15      


Asp Val Ser Phe Ile Leu Asp Arg Phe Val Lys Val Thr Pro Tyr Asn 
            20                  25                  30          


Gly Asn Ser Lys Tyr Gly Asp Gly Thr Val Ala Asn Val Arg Gly Asp 
        35                  40                  45              


Leu Gln Val Leu Ala Gln Lys Ala Ala Arg Ala Leu Pro Thr Ser Pro 
    50                  55                  60                  


Asp Gln Ala Arg His Lys Gln Lys Ile Val Ala Pro Val Lys Gln Leu 
65                  70                  75                  80  


Leu Lys Leu Ala Ala Ala Glu Glu Lys Ala Ala Pro Ala Ala Ala Lys 
                85                  90                  95      


Pro Ala Thr Thr Glu Gly Glu Phe Pro Glu Thr Arg Glu Lys Met Ser 
            100                 105                 110         


Gly Ile Arg Arg Ala Ile Ala Lys Ala Met Val His Ser Lys His Thr 
        115                 120                 125             


Ala Pro His Val Thr Leu Met Asp Glu Ala Asp Val Thr Lys Leu Val 
    130                 135                 140                 


Ala His Arg Lys Lys Phe Lys Ala Ile Ala Ala Glu Lys Gly Ile Lys 
145                 150                 155                 160 


Leu Thr Phe Leu Pro Tyr Val Val Lys Ala Leu Val Ser Ala Leu Arg 
                165                 170                 175     


Glu Tyr Pro Val Leu Asn Thr Ser Ile Asp Asp Glu Thr Glu Glu Ile 
            180                 185                 190         


Ile Gln Lys His Tyr Tyr Asn Ile Gly Ile Ala Ala Asp Thr Asp Arg 
        195                 200                 205             


Gly Leu Leu Val Pro Val Ile Lys His Ala Asp Arg Lys Pro Ile Phe 
    210                 215                 220                 


Ala Leu Ala Gln Glu Ile Asn Glu Leu Ala Glu Lys Ala Arg Asp Gly 
225                 230                 235                 240 


Lys Leu Thr Pro Gly Glu Met Lys Gly Ala Ser Cys Thr Ile Thr Asn 
                245                 250                 255     


Ile Gly Ser Ala Gly Gly Gln Trp Phe Thr Pro Val Ile Asn His Pro 
            260                 265                 270         


Glu Val Ala Ile Leu Gly Ile Gly Arg Ile Ala Glu Lys Pro Ile Val 
        275                 280                 285             


Arg Asp Gly Glu Ile Val Ala Ala Pro Met Leu Ala Leu Ser Leu Ser 
    290                 295                 300                 


Phe Asp His Arg Met Ile Asp Gly Ala Thr Ala Gln Lys Ala Leu Asn 
305                 310                 315                 320 


His Ile Lys Arg Leu Leu Ser Asp Pro Glu Leu Leu Leu Met Glu Ala 
                325                 330                 335     


<210>  7
<211>  246
<212>  DNA
<213>  artificial sequence

<220>
<223>  Polynucleotide encoding synthetic FMDV antigen corresponding to 
       VP1 of FMDV A24 strain in pET30b

<400>  7
atggaaaatt atggtggtga aacccagatt cagcgtcgtc atcataccga tattggcttt       60

attatggatc gcttcgtgaa aatccagagc tataatggca ccagcaaata tgcagttggt      120

ggtagcggtc gtcgtggtga tatgggtagc ctggcagcac gtgttgttaa acagctgcct      180

gcaagcgtta gcagccagga tcgtcataaa cagaaaatta tcgcaccggc aaaacaactg      240

ctgtga                                                                 246


<210>  8
<211>  81
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic FMDV antigen corresponding to VP1 of FMDV A24 strain in
       pET30b (pPX238)

<400>  8

Met Glu Asn Tyr Gly Gly Glu Thr Gln Ile Gln Arg Arg His His Thr 
1               5                   10                  15      


Asp Ile Gly Phe Ile Met Asp Arg Phe Val Lys Ile Gln Ser Tyr Asn 
            20                  25                  30          


Gly Thr Ser Lys Tyr Ala Val Gly Gly Ser Gly Arg Arg Gly Asp Met 
        35                  40                  45              


Gly Ser Leu Ala Ala Arg Val Val Lys Gln Leu Pro Ala Ser Val Ser 
    50                  55                  60                  


Ser Gln Asp Arg His Lys Gln Lys Ile Ile Ala Pro Ala Lys Gln Leu 
65                  70                  75                  80  


Leu 
    


<210>  9
<211>  1011
<212>  DNA
<213>  artificial sequence

<220>
<223>  Polynucleotide encoding FMDV (synthetic VP1 of FMDV A24 
       strain)-E2 fusion protein in pET30b (pPX236)

<400>  9
atggaaaatt atggtggtga aacccagatt cagcgtcgtc atcataccga tattggcttt       60

attatggatc gcttcgtgaa aatccagagc tataatggca ccagcaaata tgcagttggt      120

ggtagcggtc gtcgtggtga tatgggtagc ctggcagcac gtgttgttaa acagctgcct      180

gcaagcgtta gcagccagga tcgtcataaa cagaaaatta tcgcaccggc aaaacaactg      240

ctgaagcttg cagcagcaga agaaaaagca gcaccggcag cagcaaaacc ggcaaccacc      300

gaaggtgaat ttccggaaac ccgtgaaaaa atgagcggta ttcgtcgtgc aattgcaaaa      360

gcaatggttc atagcaaaca taccgcaccg catgttaccc tgatggatga agcagatgtt      420

accaaactgg ttgcccaccg caaaaaattc aaagcaattg cagcagagaa aggcattaaa      480

ctgacctttc tgccgtatgt tgttaaagca ctggttagcg cactgcgtga atatccggtt      540

ctgaatacca gcattgatga tgaaaccgaa gagatcatcc agaaacacta ttacaatatt      600

ggcattgcag cagataccga tcgtggtctg ctggttccgg ttattaaaca tgcagatcgt      660

aaaccgattt ttgcactggc ccaagaaatt aatgaactgg cagaaaaagc acgtgatggt      720

aaactgacac cgggtgaaat gaaaggtgca agctgtacca ttacaaatat tggtagtgcc      780

ggtggtcagt ggtttacacc ggttattaat catccggaag ttgccattct gggtattggt      840

cgtattgcag aaaaaccgat tgttcgtgat ggtgaaattg ttgcagcacc gatgctggca      900

ctgagcctga gctttgatca tcgtatgatt gatggtgcaa ccgcacagaa agcactgaat      960

catattaaac gtctgctgag cgatccggaa ctgctgctga tggaagcatg a              1011


<210>  10
<211>  336
<212>  PRT
<213>  artificial sequence

<220>
<223>  FMDV (synthetic VP1 of FMDV A24 strain )-E2 fusion protein in 
       pET30b (pPX236)

<400>  10

Met Glu Asn Tyr Gly Gly Glu Thr Gln Ile Gln Arg Arg His His Thr 
1               5                   10                  15      


Asp Ile Gly Phe Ile Met Asp Arg Phe Val Lys Ile Gln Ser Tyr Asn 
            20                  25                  30          


Gly Thr Ser Lys Tyr Ala Val Gly Gly Ser Gly Arg Arg Gly Asp Met 
        35                  40                  45              


Gly Ser Leu Ala Ala Arg Val Val Lys Gln Leu Pro Ala Ser Val Ser 
    50                  55                  60                  


Ser Gln Asp Arg His Lys Gln Lys Ile Ile Ala Pro Ala Lys Gln Leu 
65                  70                  75                  80  


Leu Lys Leu Ala Ala Ala Glu Glu Lys Ala Ala Pro Ala Ala Ala Lys 
                85                  90                  95      


Pro Ala Thr Thr Glu Gly Glu Phe Pro Glu Thr Arg Glu Lys Met Ser 
            100                 105                 110         


Gly Ile Arg Arg Ala Ile Ala Lys Ala Met Val His Ser Lys His Thr 
        115                 120                 125             


Ala Pro His Val Thr Leu Met Asp Glu Ala Asp Val Thr Lys Leu Val 
    130                 135                 140                 


Ala His Arg Lys Lys Phe Lys Ala Ile Ala Ala Glu Lys Gly Ile Lys 
145                 150                 155                 160 


Leu Thr Phe Leu Pro Tyr Val Val Lys Ala Leu Val Ser Ala Leu Arg 
                165                 170                 175     


Glu Tyr Pro Val Leu Asn Thr Ser Ile Asp Asp Glu Thr Glu Glu Ile 
            180                 185                 190         


Ile Gln Lys His Tyr Tyr Asn Ile Gly Ile Ala Ala Asp Thr Asp Arg 
        195                 200                 205             


Gly Leu Leu Val Pro Val Ile Lys His Ala Asp Arg Lys Pro Ile Phe 
    210                 215                 220                 


Ala Leu Ala Gln Glu Ile Asn Glu Leu Ala Glu Lys Ala Arg Asp Gly 
225                 230                 235                 240 


Lys Leu Thr Pro Gly Glu Met Lys Gly Ala Ser Cys Thr Ile Thr Asn 
                245                 250                 255     


Ile Gly Ser Ala Gly Gly Gln Trp Phe Thr Pro Val Ile Asn His Pro 
            260                 265                 270         


Glu Val Ala Ile Leu Gly Ile Gly Arg Ile Ala Glu Lys Pro Ile Val 
        275                 280                 285             


Arg Asp Gly Glu Ile Val Ala Ala Pro Met Leu Ala Leu Ser Leu Ser 
    290                 295                 300                 


Phe Asp His Arg Met Ile Asp Gly Ala Thr Ala Gln Lys Ala Leu Asn 
305                 310                 315                 320 


His Ile Lys Arg Leu Leu Ser Asp Pro Glu Leu Leu Leu Met Glu Ala 
                325                 330                 335     


<210>  11
<211>  240
<212>  DNA
<213>  artificial sequence

<220>
<223>  Polynucleotide encoding synthetic FMDV antigen corresponding to 
       VP1 of FMDV Asia Shamir  strain in pET30b  (pPX239)

<400>  11
atggaaaatt atggtggtga aacccagacc gcacgtcgtc tgcataccga tgttgcattt       60

attctggatc gttttgttaa actgaccgcc tataatggta aaaccgccta tggtgaaaca      120

accagccgtc gtggtgatat ggcagcactg gcacagcgtc tgagcgcacg tctgccgacc      180

agcaccaccc aggatcgtcg taaacaagaa attattgcac cggaaaaaca ggtgctgtga      240


<210>  12
<211>  79
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic FMDV antigen corresponding to VP1 of FMDV Asia Shamir  
       strain in pET30b  (pPX239)

<400>  12

Met Glu Asn Tyr Gly Gly Glu Thr Gln Thr Ala Arg Arg Leu His Thr 
1               5                   10                  15      


Asp Val Ala Phe Ile Leu Asp Arg Phe Val Lys Leu Thr Ala Tyr Asn 
            20                  25                  30          


Gly Lys Thr Ala Tyr Gly Glu Thr Thr Ser Arg Arg Gly Asp Met Ala 
        35                  40                  45              


Ala Leu Ala Gln Arg Leu Ser Ala Arg Leu Pro Thr Ser Thr Thr Gln 
    50                  55                  60                  


Asp Arg Arg Lys Gln Glu Ile Ile Ala Pro Glu Lys Gln Val Leu 
65                  70                  75                  


<210>  13
<211>  1005
<212>  DNA
<213>  artificial sequence

<220>
<223>  Polynucleotide encoding FMDV (synthetic VP1 of FMDV Asia Shamir  
       strain)-E2 fusion protein in pET30b  (pPX237)

<400>  13
atggaaaatt atggtggtga aacccagacc gcacgtcgtc tgcataccga tgttgcattt       60

attctggatc gttttgttaa actgaccgcc tataatggta aaaccgccta tggtgaaaca      120

accagccgtc gtggtgatat ggcagcactg gcacagcgtc tgagcgcacg tctgccgacc      180

agcaccaccc aggatcgtcg taaacaagaa attattgcac cggaaaaaca ggtgctgaag      240

cttgcagcag cagaagaaaa agcagcaccg gcagcagcaa aaccggcaac caccgaaggt      300

gaatttccgg aaacccgtga aaaaatgagc ggtattcgtc gtgcaattgc aaaagcaatg      360

gttcatagca aacataccgc accgcatgtt accctgatgg atgaagcaga tgttaccaaa      420

ctggttgccc accgcaaaaa attcaaagca attgcagcag agaaaggcat taaactgacc      480

tttctgccgt atgttgttaa agcactggtt agcgcactgc gtgaatatcc ggttctgaat      540

accagcattg atgatgaaac cgaagagatc atccagaaac actattacaa tattggcatt      600

gcagcagata ccgatcgtgg tctgctggtt ccggttatta aacatgcaga tcgtaaaccg      660

atttttgcac tggcccaaga aattaatgaa ctggcagaaa aagcacgtga tggtaaactg      720

acaccgggtg aaatgaaagg tgcaagctgt accattacaa atattggtag tgccggtggt      780

cagtggttta caccggttat taatcatccg gaagttgcca ttctgggtat tggtcgtatt      840

gcagaaaaac cgattgttcg tgatggtgaa attgttgcag caccgatgct ggcactgagc      900

ctgagctttg atcatcgtat gattgatggt gcaaccgcac agaaagcact gaatcatatt      960

aaacgtctgc tgagcgatcc ggaactgctg ctgatggaag catga                     1005


<210>  14
<211>  334
<212>  PRT
<213>  artificial sequence

<220>
<223>  FMDV (synthetic VP1 of FMDV Asia Shamir  strain )-E2 fusion 
       protein in pET30b  (pPX237)

<400>  14

Met Glu Asn Tyr Gly Gly Glu Thr Gln Thr Ala Arg Arg Leu His Thr 
1               5                   10                  15      


Asp Val Ala Phe Ile Leu Asp Arg Phe Val Lys Leu Thr Ala Tyr Asn 
            20                  25                  30          


Gly Lys Thr Ala Tyr Gly Glu Thr Thr Ser Arg Arg Gly Asp Met Ala 
        35                  40                  45              


Ala Leu Ala Gln Arg Leu Ser Ala Arg Leu Pro Thr Ser Thr Thr Gln 
    50                  55                  60                  


Asp Arg Arg Lys Gln Glu Ile Ile Ala Pro Glu Lys Gln Val Leu Lys 
65                  70                  75                  80  


Leu Ala Ala Ala Glu Glu Lys Ala Ala Pro Ala Ala Ala Lys Pro Ala 
                85                  90                  95      


Thr Thr Glu Gly Glu Phe Pro Glu Thr Arg Glu Lys Met Ser Gly Ile 
            100                 105                 110         


Arg Arg Ala Ile Ala Lys Ala Met Val His Ser Lys His Thr Ala Pro 
        115                 120                 125             


His Val Thr Leu Met Asp Glu Ala Asp Val Thr Lys Leu Val Ala His 
    130                 135                 140                 


Arg Lys Lys Phe Lys Ala Ile Ala Ala Glu Lys Gly Ile Lys Leu Thr 
145                 150                 155                 160 


Phe Leu Pro Tyr Val Val Lys Ala Leu Val Ser Ala Leu Arg Glu Tyr 
                165                 170                 175     


Pro Val Leu Asn Thr Ser Ile Asp Asp Glu Thr Glu Glu Ile Ile Gln 
            180                 185                 190         


Lys His Tyr Tyr Asn Ile Gly Ile Ala Ala Asp Thr Asp Arg Gly Leu 
        195                 200                 205             


Leu Val Pro Val Ile Lys His Ala Asp Arg Lys Pro Ile Phe Ala Leu 
    210                 215                 220                 


Ala Gln Glu Ile Asn Glu Leu Ala Glu Lys Ala Arg Asp Gly Lys Leu 
225                 230                 235                 240 


Thr Pro Gly Glu Met Lys Gly Ala Ser Cys Thr Ile Thr Asn Ile Gly 
                245                 250                 255     


Ser Ala Gly Gly Gln Trp Phe Thr Pro Val Ile Asn His Pro Glu Val 
            260                 265                 270         


Ala Ile Leu Gly Ile Gly Arg Ile Ala Glu Lys Pro Ile Val Arg Asp 
        275                 280                 285             


Gly Glu Ile Val Ala Ala Pro Met Leu Ala Leu Ser Leu Ser Phe Asp 
    290                 295                 300                 


His Arg Met Ile Asp Gly Ala Thr Ala Gln Lys Ala Leu Asn His Ile 
305                 310                 315                 320 


Lys Arg Leu Leu Ser Asp Pro Glu Leu Leu Leu Met Glu Ala 
                325                 330                 


<210>  15
<211>  38
<212>  PRT
<213>  artificial sequence

<220>
<223>  Linker of E2

<400>  15

Ala Ala Ala Glu Glu Lys Ala Ala Pro Ala Ala Ala Lys Pro Ala Thr 
1               5                   10                  15      


Thr Glu Gly Glu Phe Pro Glu Thr Arg Glu Lys Met Ser Gly Ile Arg 
            20                  25                  30          


Arg Ala Ile Ala Lys Ala 
        35              


