                         SEQUENCE LISTING

<110>  Evolva SA
 
<120>  PRODUCTION OF TERPENES, TERPENOIDS, AND DERIVATIVES THEREOF IN 
       RECOMBINANT HOSTS

<130>  15-1925-WO

<150>  US 62/260,456
<151>  2015-11-27

<160>  9     

<170>  PatentIn version 3.5

<210>  1
<211>  1059
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  1
atggcttcag aaaaagaaat taggagagag agattcttga acgttttccc taaattagta       60

gaggaattga acgcatcgct tttggcttac ggtatgccta aggaagcatg tgactggtat      120

gcccactcat tgaactacaa cactccaggc ggtaagctaa atagaggttt gtccgttgtg      180

gacacgtatg ctattctctc caacaagacc gttgaacaat tggggcaaga agaatacgaa      240

aaggttgcca ttctaggttg gtgcattgag ttgttgcagg cttacttctt ggtcgccgat      300

gatatgatgg acaagtccat taccagaaga ggccaaccat gttggtacaa ggttcctgaa      360

gttggggaaa ttgccatcaa tgacgcattc atgttagagg ctgctatcta caagcttttg      420

aaatctcact tcagaaacga aaaatactac atagatatca ccgaattgtt ccatgaggtc      480

accttccaaa ccgaattggg ccaattgatg gacttaatca ctgcacctga agacaaagtc      540

gacttgagta agttctccct aaagaagcac tccttcatag ttactttcaa gactgcttac      600

tattctttct acttgcctgt cgcattggcc atgtacgttg ccggtatcac ggatgaaaag      660

gatttgaaac aagccagaga tgtcttgatt ccattgggtg aatacttcca aattcaagat      720

gactacttag actgcttcgg taccccagaa cagatcggta agatcggtac agatatccaa      780

gataacaaat gttcttgggt aatcaacaag gcattggaac ttgcttccgc agaacaaaga      840

aagactttag acgaaaatta cggtaagaag gactcagtcg cagaagccaa atgcaaaaag      900

attttcaatg acttgaaaat tgaacagcta taccacgaat atgaagagtc tattgccaag      960

gatttgaagg ccaaaatttc tcaggtcgat gagtctcgtg gcttcaaagc tgatgtctta     1020

actgcgttct tgaacaaagt ttacaagaga agcaaatag                            1059


<210>  2
<211>  704
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  2

Met Ala Ser Glu Lys Glu Ile Arg Arg Glu Arg Phe Leu Asn Val Phe 
1               5                   10                  15      


Pro Lys Leu Val Glu Glu Leu Asn Ala Ser Leu Leu Ala Tyr Gly Met 
            20                  25                  30          


Pro Lys Glu Ala Cys Asp Trp Tyr Ala His Ser Leu Asn Tyr Asn Thr 
        35                  40                  45              


Pro Gly Gly Lys Leu Asn Arg Gly Leu Ser Val Val Asp Thr Tyr Ala 
    50                  55                  60                  


Ile Leu Ser Asn Lys Thr Val Glu Gln Leu Gly Gln Glu Glu Tyr Glu 
65                  70                  75                  80  


Lys Val Ala Ile Leu Gly Trp Cys Ile Glu Leu Leu Gln Ala Tyr Phe 
                85                  90                  95      


Leu Val Ala Asp Asp Met Met Asp Lys Ser Ile Thr Arg Arg Gly Gln 
            100                 105                 110         


Pro Cys Trp Tyr Lys Val Pro Glu Val Gly Glu Ile Ala Ile Asn Asp 
        115                 120                 125             


Ala Phe Met Leu Glu Ala Ala Ile Tyr Lys Leu Leu Lys Ser His Phe 
    130                 135                 140                 


Arg Asn Glu Lys Tyr Tyr Ile Asp Ile Thr Glu Leu Phe His Glu Val 
145                 150                 155                 160 


Thr Phe Gln Thr Glu Leu Gly Gln Leu Met Asp Leu Ile Thr Ala Pro 
                165                 170                 175     


Glu Asp Lys Val Asp Leu Ser Lys Phe Ser Leu Lys Lys His Ser Phe 
            180                 185                 190         


Ile Val Thr Phe Lys Thr Ala Tyr Tyr Ser Phe Tyr Leu Pro Val Ala 
        195                 200                 205             


Leu Ala Met Tyr Val Ala Gly Ile Thr Asp Glu Lys Asp Leu Lys Gln 
    210                 215                 220                 


Ala Arg Asp Val Leu Ile Pro Leu Gly Glu Tyr Phe Gln Ile Gln Asp 
225                 230                 235                 240 


Asp Tyr Leu Asp Cys Phe Gly Thr Pro Glu Gln Ile Gly Lys Ile Gly 
                245                 250                 255     


Thr Asp Ile Gln Asp Asn Lys Cys Ser Trp Val Ile Asn Lys Ala Leu 
            260                 265                 270         


Glu Leu Ala Ser Ala Glu Gln Arg Lys Thr Leu Asp Glu Asn Tyr Gly 
        275                 280                 285             


Lys Lys Asp Ser Val Ala Glu Ala Lys Cys Lys Lys Ile Phe Asn Asp 
    290                 295                 300                 


Leu Lys Ile Glu Gln Leu Tyr His Glu Tyr Glu Glu Ser Ile Ala Lys 
305                 310                 315                 320 


Asp Leu Lys Ala Lys Ile Ser Gln Val Asp Glu Ser Arg Gly Phe Lys 
                325                 330                 335     


Ala Asp Val Leu Thr Ala Phe Leu Asn Lys Val Tyr Lys Arg Ser Lys 
            340                 345                 350         


Met Ala Ser Glu Lys Glu Ile Arg Arg Glu Arg Phe Leu Asn Val Phe 
        355                 360                 365             


Pro Lys Leu Val Glu Glu Leu Asn Ala Ser Leu Leu Ala Tyr Gly Met 
    370                 375                 380                 


Pro Lys Glu Ala Cys Asp Trp Tyr Ala His Ser Leu Asn Tyr Asn Thr 
385                 390                 395                 400 


Pro Gly Gly Lys Leu Asn Arg Gly Leu Ser Val Val Asp Thr Tyr Ala 
                405                 410                 415     


Ile Leu Ser Asn Lys Thr Val Glu Gln Leu Gly Gln Glu Glu Tyr Glu 
            420                 425                 430         


Lys Val Ala Ile Leu Gly Trp Cys Ile Glu Leu Leu Gln Ala Tyr Phe 
        435                 440                 445             


Leu Val Ala Asp Asp Met Met Asp Lys Ser Ile Thr Arg Arg Gly Gln 
    450                 455                 460                 


Pro Cys Trp Tyr Lys Val Pro Glu Val Gly Glu Ile Ala Ile Asn Asp 
465                 470                 475                 480 


Ala Phe Met Leu Glu Ala Ala Ile Tyr Lys Leu Leu Lys Ser His Phe 
                485                 490                 495     


Arg Asn Glu Lys Tyr Tyr Ile Asp Ile Thr Glu Leu Phe His Glu Val 
            500                 505                 510         


Thr Phe Gln Thr Glu Leu Gly Gln Leu Met Asp Leu Ile Thr Ala Pro 
        515                 520                 525             


Glu Asp Lys Val Asp Leu Ser Lys Phe Ser Leu Lys Lys His Ser Phe 
    530                 535                 540                 


Ile Val Thr Phe Lys Thr Ala Tyr Tyr Ser Phe Tyr Leu Pro Val Ala 
545                 550                 555                 560 


Leu Ala Met Tyr Val Ala Gly Ile Thr Asp Glu Lys Asp Leu Lys Gln 
                565                 570                 575     


Ala Arg Asp Val Leu Ile Pro Leu Gly Glu Tyr Phe Gln Ile Gln Asp 
            580                 585                 590         


Asp Tyr Leu Asp Cys Phe Gly Thr Pro Glu Gln Ile Gly Lys Ile Gly 
        595                 600                 605             


Thr Asp Ile Gln Asp Asn Lys Cys Ser Trp Val Ile Asn Lys Ala Leu 
    610                 615                 620                 


Glu Leu Ala Ser Ala Glu Gln Arg Lys Thr Leu Asp Glu Asn Tyr Gly 
625                 630                 635                 640 


Lys Lys Asp Ser Val Ala Glu Ala Lys Cys Lys Lys Ile Phe Asn Asp 
                645                 650                 655     


Leu Lys Ile Glu Gln Leu Tyr His Glu Tyr Glu Glu Ser Ile Ala Lys 
            660                 665                 670         


Asp Leu Lys Ala Lys Ile Ser Gln Val Asp Glu Ser Arg Gly Phe Lys 
        675                 680                 685             


Ala Asp Val Leu Thr Ala Phe Leu Asn Lys Val Tyr Lys Arg Ser Lys 
    690                 695                 700                 


<210>  3
<211>  789
<212>  DNA
<213>  Mycobacterium tuberculosis

<400>  3
atggagatca tcccgcctcg gctcaaagag ccgttgtacc ggctctacga gctgcgcctg       60

cggcagggct tggccgcctc gaaatccgac ctgccccggc acatagccgt gctgtgcgac      120

ggcaaccggc gatgggcgcg cagcgcgggc tacgacgacg tcagctacgg ctaccggatg      180

ggtgcggcca agatcgccga aatgctgcgg tggtgccacg aagccggcat cgaactggcc      240

accgtctatc tgctgtccac cgaaaacctg cagcgcgatc ccgacgagct tgcagcactc      300

atcgagatca tcaccgatgt cgtggaagag atctgcgcac cggccaacca ctggagtgtg      360

cggacggtcg gggatctggg gttgatcggc gaggaaccgg cccggcggct gcgcggtgcg      420

gtggaatcca ccccggaggt ggcctcgttt catgtcaacg ttgctgttgg ctacggcggg      480

cgccgcgaga tcgtcgacgc tgtgcgcgcg ttgttgagca aggaactcgc caacggggcc      540

acagcggagg aactcgtcga cgcggtgacc gtcgagggta tctcggaaaa cctgtacacc      600

tcaggccaac ccgaccccga tttggtgata cgcacctccg gcgagcaacg cttgtccggg      660

ttcttgctgt ggcaaagcgc ctactcggag atgtggttca ccgaggcgca ctggccggcg      720

tttcgccacg tcgattttct acgcgcgctg cgtgactaca gtgcgaggca tcgcagctac      780

ggcaggtga                                                              789


<210>  4
<211>  262
<212>  PRT
<213>  Mycobacterium tuberculosis

<400>  4

Met Glu Ile Ile Pro Pro Arg Leu Lys Glu Pro Leu Tyr Arg Leu Tyr 
1               5                   10                  15      


Glu Leu Arg Leu Arg Gln Gly Leu Ala Ala Ser Lys Ser Asp Leu Pro 
            20                  25                  30          


Arg His Ile Ala Val Leu Cys Asp Gly Asn Arg Arg Trp Ala Arg Ser 
        35                  40                  45              


Ala Gly Tyr Asp Asp Val Ser Tyr Gly Tyr Arg Met Gly Ala Ala Lys 
    50                  55                  60                  


Ile Ala Glu Met Leu Arg Trp Cys His Glu Ala Gly Ile Glu Leu Ala 
65                  70                  75                  80  


Thr Val Tyr Leu Leu Ser Thr Glu Asn Leu Gln Arg Asp Pro Asp Glu 
                85                  90                  95      


Leu Ala Ala Leu Ile Glu Ile Ile Thr Asp Val Val Glu Glu Ile Cys 
            100                 105                 110         


Ala Pro Ala Asn His Trp Ser Val Arg Thr Val Gly Asp Leu Gly Leu 
        115                 120                 125             


Ile Gly Glu Glu Pro Ala Arg Arg Leu Arg Gly Ala Val Glu Ser Thr 
    130                 135                 140                 


Pro Glu Val Ala Ser Phe His Val Asn Val Ala Val Gly Tyr Gly Gly 
145                 150                 155                 160 


Arg Arg Glu Ile Val Asp Ala Val Arg Ala Leu Leu Ser Lys Glu Leu 
                165                 170                 175     


Ala Asn Gly Ala Thr Ala Glu Glu Leu Val Asp Ala Val Thr Val Glu 
            180                 185                 190         


Gly Ile Ser Glu Asn Leu Tyr Thr Ser Gly Gln Pro Asp Pro Asp Leu 
        195                 200                 205             


Val Ile Arg Thr Ser Gly Glu Gln Arg Leu Ser Gly Phe Leu Leu Trp 
    210                 215                 220                 


Gln Ser Ala Tyr Ser Glu Met Trp Phe Thr Glu Ala His Trp Pro Ala 
225                 230                 235                 240 


Phe Arg His Val Asp Phe Leu Arg Ala Leu Arg Asp Tyr Ser Ala Arg 
                245                 250                 255     


His Arg Ser Tyr Gly Arg 
            260         


<210>  5
<211>  1647
<212>  DNA
<213>  Nicotiana attenuata

<400>  5
atggcttctg ctgctgttgg taattatgaa gaggaaattg taagaccagt cgctgatttt       60

tcaccttcct tgtggggaga ccatttctta agttttagca tagataacca agtggcagag      120

aaatacgccc aggaaatcga accactaaag gagcaaacta ggtctatgct tttggctaca      180

ggcagaaaat tagcagacac ccttaatttg attgatacta tagaaaggtt gggtatctct      240

tattacttcg aaaaggagat tgacgaaata cttgaccaca tctacaacca gaactccaac      300

tgtaacgact tttgcacaag cgccttgcaa ttcagattat tgagacaaca tggctttaac      360

atctcccctc agattttcag caaattccag gacgaaaatg gcaagtttag ggagtctctt      420

gcttcagatg ttttgggttt acttaaccta tacgaggcct ctcacgtaag aacccatgct      480

gatgatatct tagaggatgc ccttgcattt tctactatac acttggaaag tgccgcacca      540

caccttaagt cacctctaag agaacaagtc acacatgcac ttgaacaatg tctacataag      600

ggtgtgccaa gggttgaaac cagattcttc atttccagca tatatgaaaa agagcaaagc      660

aagaataatg tccttttaag gtttgctaag ttggacttca acttattgca gatgttgcac      720

aaacaggaat tagccgaagt atcaagatgg tggaaagatc ttgattttgt gaccactttg      780

ccttacgcaa gagatagggt tgttgagtgc tatttctggg ctttaggagt atactttgaa      840

ccacaatatt ctcaagccag agtcatgctt gtgaaaacaa tcagcatgat ttccatagtt      900

gatgacactt tcgatgcata cggcacagta aaagaactag aggcttatac tgacgccatc      960

caaagatggg atattaatga aattgatagg ttgcctcatt acatgaaaat aagctataag     1020

gcaattttgg acttatacaa ggactacgag aaagagttgt ccagtgctga aaagtcccat     1080

attgtctgcc acgctataga aagaatgaag gaagttgtgg gtcattacaa cgttgagtca     1140

acctggttta tcgaaggata tatgcctcct gtttccgaat acttatccaa cgccctagca     1200

acaactacct actattactt ggctacaact agttatcttg gtatgaaaag cgccacagaa     1260

caagatttcg agtggttatc aaagaaccca aaaatcttgg aagctagcgt cattatatgc     1320

agggtgattg atgataccgc tacttacgaa gttgagaaaa gcagaggcca gattgccaca     1380

ggtatagaat gttgtatgag agactatgga attagcacta aaaaggcaat ggccaaattt     1440

cagaaaatgg cagagaccgc ttggaaggat attaatgaag gtttgcttag gcctacacca     1500

gtgagtactg agttcttgac ccttatattg aatcttgcca gaatcgtcga ggttacatac     1560

attcataatt tggacggcta tactcaccca gaaaaagtgt taaagcctca tataatcaat     1620

cttctagtcg actccattaa gatctga                                         1647


<210>  6
<211>  548
<212>  PRT
<213>  Nicotiana attenuata

<400>  6

Met Ala Ser Ala Ala Val Gly Asn Tyr Glu Glu Glu Ile Val Arg Pro 
1               5                   10                  15      


Val Ala Asp Phe Ser Pro Ser Leu Trp Gly Asp His Phe Leu Ser Phe 
            20                  25                  30          


Ser Ile Asp Asn Gln Val Ala Glu Lys Tyr Ala Gln Glu Ile Glu Pro 
        35                  40                  45              


Leu Lys Glu Gln Thr Arg Ser Met Leu Leu Ala Thr Gly Arg Lys Leu 
    50                  55                  60                  


Ala Asp Thr Leu Asn Leu Ile Asp Thr Ile Glu Arg Leu Gly Ile Ser 
65                  70                  75                  80  


Tyr Tyr Phe Glu Lys Glu Ile Asp Glu Ile Leu Asp His Ile Tyr Asn 
                85                  90                  95      


Gln Asn Ser Asn Cys Asn Asp Phe Cys Thr Ser Ala Leu Gln Phe Arg 
            100                 105                 110         


Leu Leu Arg Gln His Gly Phe Asn Ile Ser Pro Gln Ile Phe Ser Lys 
        115                 120                 125             


Phe Gln Asp Glu Asn Gly Lys Phe Arg Glu Ser Leu Ala Ser Asp Val 
    130                 135                 140                 


Leu Gly Leu Leu Asn Leu Tyr Glu Ala Ser His Val Arg Thr His Ala 
145                 150                 155                 160 


Asp Asp Ile Leu Glu Asp Ala Leu Ala Phe Ser Thr Ile His Leu Glu 
                165                 170                 175     


Ser Ala Ala Pro His Leu Lys Ser Pro Leu Arg Glu Gln Val Thr His 
            180                 185                 190         


Ala Leu Glu Gln Cys Leu His Lys Gly Val Pro Arg Val Glu Thr Arg 
        195                 200                 205             


Phe Phe Ile Ser Ser Ile Tyr Glu Lys Glu Gln Ser Lys Asn Asn Val 
    210                 215                 220                 


Leu Leu Arg Phe Ala Lys Leu Asp Phe Asn Leu Leu Gln Met Leu His 
225                 230                 235                 240 


Lys Gln Glu Leu Ala Glu Val Ser Arg Trp Trp Lys Asp Leu Asp Phe 
                245                 250                 255     


Val Thr Thr Leu Pro Tyr Ala Arg Asp Arg Val Val Glu Cys Tyr Phe 
            260                 265                 270         


Trp Ala Leu Gly Val Tyr Phe Glu Pro Gln Tyr Ser Gln Ala Arg Val 
        275                 280                 285             


Met Leu Val Lys Thr Ile Ser Met Ile Ser Ile Val Asp Asp Thr Phe 
    290                 295                 300                 


Asp Ala Tyr Gly Thr Val Lys Glu Leu Glu Ala Tyr Thr Asp Ala Ile 
305                 310                 315                 320 


Gln Arg Trp Asp Ile Asn Glu Ile Asp Arg Leu Pro His Tyr Met Lys 
                325                 330                 335     


Ile Ser Tyr Lys Ala Ile Leu Asp Leu Tyr Lys Asp Tyr Glu Lys Glu 
            340                 345                 350         


Leu Ser Ser Ala Glu Lys Ser His Ile Val Cys His Ala Ile Glu Arg 
        355                 360                 365             


Met Lys Glu Val Val Gly His Tyr Asn Val Glu Ser Thr Trp Phe Ile 
    370                 375                 380                 


Glu Gly Tyr Met Pro Pro Val Ser Glu Tyr Leu Ser Asn Ala Leu Ala 
385                 390                 395                 400 


Thr Thr Thr Tyr Tyr Tyr Leu Ala Thr Thr Ser Tyr Leu Gly Met Lys 
                405                 410                 415     


Ser Ala Thr Glu Gln Asp Phe Glu Trp Leu Ser Lys Asn Pro Lys Ile 
            420                 425                 430         


Leu Glu Ala Ser Val Ile Ile Cys Arg Val Ile Asp Asp Thr Ala Thr 
        435                 440                 445             


Tyr Glu Val Glu Lys Ser Arg Gly Gln Ile Ala Thr Gly Ile Glu Cys 
    450                 455                 460                 


Cys Met Arg Asp Tyr Gly Ile Ser Thr Lys Lys Ala Met Ala Lys Phe 
465                 470                 475                 480 


Gln Lys Met Ala Glu Thr Ala Trp Lys Asp Ile Asn Glu Gly Leu Leu 
                485                 490                 495     


Arg Pro Thr Pro Val Ser Thr Glu Phe Leu Thr Leu Ile Leu Asn Leu 
            500                 505                 510         


Ala Arg Ile Val Glu Val Thr Tyr Ile His Asn Leu Asp Gly Tyr Thr 
        515                 520                 525             


His Pro Glu Lys Val Leu Lys Pro His Ile Ile Asn Leu Leu Val Asp 
    530                 535                 540                 


Ser Ile Lys Ile 
545             


<210>  7
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  UP element


<220>
<221>  misc_feature
<222>  (4)..(5)

<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  w is a or t

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  w is a or t

<220>
<221>  misc_feature
<222>  (12)..(14)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (18)..(20)
<223>  n is a, c, g, or t

<400>  7
aaawwtwttt tnnnaaannn                                                   20


<210>  8
<211>  491
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  KEX2 promoter

<400>  8
tcagcagctc tgatgtagat acacgtatct cgacatgttt tatttttact atacatacat       60

aaaagaaata aaaaatgata acgtgtatat tattattcat ataatcaatg agggtcattt      120

tctgaaacgc aaaaaacggt aaatggaaaa aaaataaaga tagaaaaaga aaacaaacaa      180

aggaaaggtt agcatattaa ataactgagc tgatacttca acagcatcgc tgaagagaac      240

agtattgaaa ccgaaacatt ttctaaaggc aaacaaggta ctccatattt gctggacgtg      300

ttctttctct cgtttcatat gcataattct gtcataagcc tgttcttttt cctggcttaa      360

acatcccgtt ttgtaaaaga gaaatctatt ccacatattt cattcattcg gctaccatac      420

taaggataaa ctaatcccgt tgttttttgg cctcgtcaca taattataaa ctactaaccc      480

attatcagaa g                                                           491


<210>  9
<211>  306
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CYC1 promoter with stemloop sequence

<400>  9
cgttggttgg tggatcaagc ccacgcgtag gcaatcctcg agcagatccg ccaggcgtgt       60

atatatagcg tggatggcca ggcaacttta gtgctgacac atacaggcat atatatatgt      120

gtgcgacgac acatgatcat atggcatgca tgtgctctgt atgtatataa aactcttgtt      180

ttcttctttt ctctaaatat tctttcctta tacattagga cctttgcagc ataaattact      240

atacttctat agacacacaa acacaaatac acacactaaa ttaatatgaa ttcgttaacg      300

aattca                                                                 306


