                         SEQUENCE LISTING

<110>  RUSSELL, David W.
       HIRAMOTO, Takafumi
       LI, Li
 
<120>  HEMATOPOIETIC CELL GENE EDITING

<130>  16-1500-PCT

<150>  US 62/257,601
<151>  2015-11-19

<160>  61    

<170>  PatentIn version 3.5

<210>  1
<211>  1560
<212>  DNA
<213>  Homo sapiens

<400>  1
agaggaaacg tgtgggtggg gaggggtagt gggtgaggga cccaggttcc tgacacagac       60

agactacacc cagggaatga agagcaagcg ccatgttgaa gccatcatta ccattcacat      120

ccctcttatt cctgcagctg cccctgctgg gagtggggct gaacacgaca attctgacgc      180

ccaatgggaa tgaagacacc acagctgatt tcttcctgac cactatgccc actgactccc      240

tcagtgtttc cactctgccc ctcccagagg ttcagtgttt tgtgttcaat gtcgagtaca      300

tgaattgcac ttggaacagc agctctgagc cccagcctac caacctcact ctgcattatt      360

ggtacaagaa ctcggataat gataaagtcc agaagtgcag ccactatcta ttctctgaag      420

aaatcacttc tggctgtcag ttgcaaaaaa aggagatcca cctctaccaa acatttgttg      480

ttcagctcca ggacccacgg gaacccagga gacaggccac acagatgcta aaactgcaga      540

atctggtgat cccctgggct ccagagaacc taacacttca caaactgagt gaatcccagc      600

tagaactgaa ctggaacaac agattcttga accactgttt ggagcacttg gtgcagtacc      660

ggactgactg ggaccacagc tggactgaac aatcagtgga ttatagacat aagttctcct      720

tgcctagtgt ggatgggcag aaacgctaca cgtttcgtgt tcggagccgc tttaacccac      780

tctgtggaag tgctcagcat tggagtgaat ggagccaccc aatccactgg gggagcaata      840

cttcaaaaga gaatcctttc ctgtttgcat tggaagccgt ggttatctct gttggctcca      900

tgggattgat tatcagcctt ctctgtgtgt atttctggct ggaacggacg atgccccgaa      960

ttcccaccct gaagaaccta gaggatcttg ttactgaata ccacgggaac ttttcggcct     1020

ggagtggtgt gtctaaggga ctggctgaga gtctgcagcc agactacagt gaacgactct     1080

gcctcgtcag tgagattccc ccaaaaggag gggcccttgg ggaggggcct ggggcctccc     1140

catgcaacca gcatagcccc tactgggccc ccccatgtta caccctaaag cctgaaacct     1200

gaaccccaat cctctgacag aagaacccca gggtcctgta gccctaagtg gtactaactt     1260

tccttcattc aacccacctg cgtctcatac tcacctcacc ccactgtggc tgatttggaa     1320

ttttgtgccc ccatgtaagc accccttcat ttggcattcc ccacttgaga attacccttt     1380

tgccccgaac atgtttttct tctccctcag tctggccctt ccttttcgca ggattcttcc     1440

tccctccctc tttccctccc ttcctctttc catctaccct ccgattgttc ctgaaccgat     1500

gagaaataaa gtttctgttg ataatcatca aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1560


<210>  2
<211>  369
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Leu Lys Pro Ser Leu Pro Phe Thr Ser Leu Leu Phe Leu Gln Leu 
1               5                   10                  15      


Pro Leu Leu Gly Val Gly Leu Asn Thr Thr Ile Leu Thr Pro Asn Gly 
            20                  25                  30          


Asn Glu Asp Thr Thr Ala Asp Phe Phe Leu Thr Thr Met Pro Thr Asp 
        35                  40                  45              


Ser Leu Ser Val Ser Thr Leu Pro Leu Pro Glu Val Gln Cys Phe Val 
    50                  55                  60                  


Phe Asn Val Glu Tyr Met Asn Cys Thr Trp Asn Ser Ser Ser Glu Pro 
65                  70                  75                  80  


Gln Pro Thr Asn Leu Thr Leu His Tyr Trp Tyr Lys Asn Ser Asp Asn 
                85                  90                  95      


Asp Lys Val Gln Lys Cys Ser His Tyr Leu Phe Ser Glu Glu Ile Thr 
            100                 105                 110         


Ser Gly Cys Gln Leu Gln Lys Lys Glu Ile His Leu Tyr Gln Thr Phe 
        115                 120                 125             


Val Val Gln Leu Gln Asp Pro Arg Glu Pro Arg Arg Gln Ala Thr Gln 
    130                 135                 140                 


Met Leu Lys Leu Gln Asn Leu Val Ile Pro Trp Ala Pro Glu Asn Leu 
145                 150                 155                 160 


Thr Leu His Lys Leu Ser Glu Ser Gln Leu Glu Leu Asn Trp Asn Asn 
                165                 170                 175     


Arg Phe Leu Asn His Cys Leu Glu His Leu Val Gln Tyr Arg Thr Asp 
            180                 185                 190         


Trp Asp His Ser Trp Thr Glu Gln Ser Val Asp Tyr Arg His Lys Phe 
        195                 200                 205             


Ser Leu Pro Ser Val Asp Gly Gln Lys Arg Tyr Thr Phe Arg Val Arg 
    210                 215                 220                 


Ser Arg Phe Asn Pro Leu Cys Gly Ser Ala Gln His Trp Ser Glu Trp 
225                 230                 235                 240 


Ser His Pro Ile His Trp Gly Ser Asn Thr Ser Lys Glu Asn Pro Phe 
                245                 250                 255     


Leu Phe Ala Leu Glu Ala Val Val Ile Ser Val Gly Ser Met Gly Leu 
            260                 265                 270         


Ile Ile Ser Leu Leu Cys Val Tyr Phe Trp Leu Glu Arg Thr Met Pro 
        275                 280                 285             


Arg Ile Pro Thr Leu Lys Asn Leu Glu Asp Leu Val Thr Glu Tyr His 
    290                 295                 300                 


Gly Asn Phe Ser Ala Trp Ser Gly Val Ser Lys Gly Leu Ala Glu Ser 
305                 310                 315                 320 


Leu Gln Pro Asp Tyr Ser Glu Arg Leu Cys Leu Val Ser Glu Ile Pro 
                325                 330                 335     


Pro Lys Gly Gly Ala Leu Gly Glu Gly Pro Gly Ala Ser Pro Cys Asn 
            340                 345                 350         


Gln His Ser Pro Tyr Trp Ala Pro Pro Cys Tyr Thr Leu Lys Pro Glu 
        355                 360                 365             


Thr 
    


<210>  3
<211>  1574
<212>  DNA
<213>  Homo sapiens

<400>  3
gggcggggcg ggaggcgggg cccggcccgt taagaagagc gtggccggcc gcggccaccg       60

ctggccccag ggaaagccga gcggccaccg agccggcaga gacccaccga gcggcggcgg      120

agggagcagc gccggggcgc acgagggcac catggcccag acgcccgcct tcgacaagcc      180

caaagtagaa ctgcatgtcc acctagacgg atccatcaag cctgaaacca tcttatacta      240

tggcaggagg agagggatcg ccctcccagc taacacagca gaggggctgc tgaacgtcat      300

tggcatggac aagccgctca cccttccaga cttcctggcc aagtttgact actacatgcc      360

tgctatcgcg ggctgccggg aggctatcaa aaggatcgcc tatgagtttg tagagatgaa      420

ggccaaagag ggcgtggtgt atgtggaggt gcggtacagt ccgcacctgc tggccaactc      480

caaagtggag ccaatcccct ggaaccaggc tgaaggggac ctcaccccag acgaggtggt      540

ggccctagtg ggccagggcc tgcaggaggg ggagcgagac ttcggggtca aggcccggtc      600

catcctgtgc tgcatgcgcc accagcccaa ctggtccccc aaggtggtgg agctgtgtaa      660

gaagtaccag cagcagaccg tggtagccat tgacctggct ggagatgaga ccatcccagg      720

aagcagcctc ttgcctggac atgtccaggc ctaccaggag gctgtgaaga gcggcattca      780

ccgtactgtc cacgccgggg aggtgggctc ggccgaagta gtaaaagagg ctgtggacat      840

actcaagaca gagcggctgg gacacggcta ccacaccctg gaagaccagg ccctttataa      900

caggctgcgg caggaaaaca tgcacttcga gatctgcccc tggtccagct acctcactgg      960

tgcctggaag ccggacacgg agcatgcagt cattcggctc aaaaatgacc aggctaacta     1020

ctcgctcaac acagatgacc cgctcatctt caagtccacc ctggacactg attaccagat     1080

gaccaaacgg gacatgggct ttactgaaga ggagtttaaa aggctgaaca tcaatgcggc     1140

caaatctagt ttcctcccag aagatgaaaa gagggagctt ctcgacctgc tctataaagc     1200

ctatgggatg ccaccttcag cctctgcagg gcagaacctc tgaagacgcc actcctccaa     1260

gccttcaccc tgtggagtca ccccaactct gtggggctga gcaacatttt tacatttatt     1320

ccttccaaga agaccatgat ctcaatagtc agttactgat gctcctgaac cctatgtgtc     1380

catttctgca cacacgtata cctcggcatg gccgcgtcac ttctctgatt atgtgccctg     1440

gccagggacc agcgcccttg cacatgggca tggttgaatc tgaaaccctc cttctgtggc     1500

aacttgtact gaaaatctgg tgctcaataa agaagcccat ggctggtggc atgcagcaaa     1560

aaaaaaaaaa aaaa                                                       1574


<210>  4
<211>  363
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Ala Gln Thr Pro Ala Phe Asp Lys Pro Lys Val Glu Leu His Val 
1               5                   10                  15      


His Leu Asp Gly Ser Ile Lys Pro Glu Thr Ile Leu Tyr Tyr Gly Arg 
            20                  25                  30          


Arg Arg Gly Ile Ala Leu Pro Ala Asn Thr Ala Glu Gly Leu Leu Asn 
        35                  40                  45              


Val Ile Gly Met Asp Lys Pro Leu Thr Leu Pro Asp Phe Leu Ala Lys 
    50                  55                  60                  


Phe Asp Tyr Tyr Met Pro Ala Ile Ala Gly Cys Arg Glu Ala Ile Lys 
65                  70                  75                  80  


Arg Ile Ala Tyr Glu Phe Val Glu Met Lys Ala Lys Glu Gly Val Val 
                85                  90                  95      


Tyr Val Glu Val Arg Tyr Ser Pro His Leu Leu Ala Asn Ser Lys Val 
            100                 105                 110         


Glu Pro Ile Pro Trp Asn Gln Ala Glu Gly Asp Leu Thr Pro Asp Glu 
        115                 120                 125             


Val Val Ala Leu Val Gly Gln Gly Leu Gln Glu Gly Glu Arg Asp Phe 
    130                 135                 140                 


Gly Val Lys Ala Arg Ser Ile Leu Cys Cys Met Arg His Gln Pro Asn 
145                 150                 155                 160 


Trp Ser Pro Lys Val Val Glu Leu Cys Lys Lys Tyr Gln Gln Gln Thr 
                165                 170                 175     


Val Val Ala Ile Asp Leu Ala Gly Asp Glu Thr Ile Pro Gly Ser Ser 
            180                 185                 190         


Leu Leu Pro Gly His Val Gln Ala Tyr Gln Glu Ala Val Lys Ser Gly 
        195                 200                 205             


Ile His Arg Thr Val His Ala Gly Glu Val Gly Ser Ala Glu Val Val 
    210                 215                 220                 


Lys Glu Ala Val Asp Ile Leu Lys Thr Glu Arg Leu Gly His Gly Tyr 
225                 230                 235                 240 


His Thr Leu Glu Asp Gln Ala Leu Tyr Asn Arg Leu Arg Gln Glu Asn 
                245                 250                 255     


Met His Phe Glu Ile Cys Pro Trp Ser Ser Tyr Leu Thr Gly Ala Trp 
            260                 265                 270         


Lys Pro Asp Thr Glu His Ala Val Ile Arg Leu Lys Asn Asp Gln Ala 
        275                 280                 285             


Asn Tyr Ser Leu Asn Thr Asp Asp Pro Leu Ile Phe Lys Ser Thr Leu 
    290                 295                 300                 


Asp Thr Asp Tyr Gln Met Thr Lys Arg Asp Met Gly Phe Thr Glu Glu 
305                 310                 315                 320 


Glu Phe Lys Arg Leu Asn Ile Asn Ala Ala Lys Ser Ser Phe Leu Pro 
                325                 330                 335     


Glu Asp Glu Lys Arg Glu Leu Leu Asp Leu Leu Tyr Lys Ala Tyr Gly 
            340                 345                 350         


Met Pro Pro Ser Ala Ser Ala Gly Gln Asn Leu 
        355                 360             


<210>  5
<211>  4617
<212>  DNA
<213>  Homo sapiens

<400>  5
atctaagctt ctctgtcttc ctccctccct cccttcctct tactctcatt catttcatac       60

acactggctc acacatctac tctctctctc tatctctctc agaatgacaa ttctaggtac      120

aacttttggc atggtttttt ctttacttca agtcgtttct ggagaaagtg gctatgctca      180

aaatggagac ttggaagatg cagaactgga tgactactca ttctcatgct atagccagtt      240

ggaagtgaat ggatcgcagc actcactgac ctgtgctttt gaggacccag atgtcaacat      300

caccaatctg gaatttgaaa tatgtggggc cctcgtggag gtaaagtgcc tgaatttcag      360

gaaactacaa gagatatatt tcatcgagac aaagaaattc ttactgattg gaaagagcaa      420

tatatgtgtg aaggttggag aaaagagtct aacctgcaaa aaaatagacc taaccactat      480

agttaaacct gaggctcctt ttgacctgag tgtcgtctat cgggaaggag ccaatgactt      540

tgtggtgaca tttaatacat cacacttgca aaagaagtat gtaaaagttt taatgcacga      600

tgtagcttac cgccaggaaa aggatgaaaa caaatggacg catgtgaatt tatccagcac      660

aaagctgaca ctcctgcaga gaaagctcca accggcagca atgtatgaga ttaaagttcg      720

atccatccct gatcactatt ttaaaggctt ctggagtgaa tggagtccaa gttattactt      780

cagaactcca gagatcaata atagctcagg ggagatggat cctatcttac taaccatcag      840

cattttgagt tttttctctg tcgctctgtt ggtcatcttg gcctgtgtgt tatggaaaaa      900

aaggattaag cctatcgtat ggcccagtct ccccgatcat aagaagactc tggaacatct      960

ttgtaagaaa ccaagaaaaa atttaaatgt gagtttcaat cctgaaagtt tcctggactg     1020

ccagattcat agggtggatg acattcaagc tagagatgaa gtggaaggtt ttctgcaaga     1080

tacgtttcct cagcaactag aagaatctga gaagcagagg cttggagggg atgtgcagag     1140

ccccaactgc ccatctgagg atgtagtcat cactccagaa agctttggaa gagattcatc     1200

cctcacatgc ctggctggga atgtcagtgc atgtgacgcc cctattctct cctcttccag     1260

gtccctagac tgcagggaga gtggcaagaa tgggcctcat gtgtaccagg acctcctgct     1320

tagccttggg actacaaaca gcacgctgcc ccctccattt tctctccaat ctggaatcct     1380

gacattgaac ccagttgctc agggtcagcc cattcttact tccctgggat caaatcaaga     1440

agaagcatat gtcaccatgt ccagcttcta ccaaaaccag tgaagtgtaa gaaacccaga     1500

ctgaacttac cgtgagcgac aaagatgatt taaaagggaa gtctagagtt cctagtctcc     1560

ctcacagcac agagaagaca aaattagcaa aaccccacta cacagtctgc aagattctga     1620

aacattgctt tgaccactct tcctgagttc agtggcactc aacatgagtc aagagcatcc     1680

tgcttctacc atgtggattt ggtcacaagg tttaaggtga cccaatgatt cagctattta     1740

aaaaaaaaag aggaaagaat gaaagagtaa aggaaatgat tgaggagtga ggaaggcagg     1800

aagagagcat gagaggaaag aaagaaagga aaataaaaaa tgatagttgc cattattagg     1860

atttaatata tatccagtgc tttgcaagtg ctctgcgcac cttgtctcac tccatcctga     1920

caataatcct gggaggtgtg tgcaattact acgactactc tcttttttat agatcattaa     1980

attcagaact aaggagttaa gtaacttgtc caagttgttc acacagtgaa gggaggggcc     2040

aagatatgat ggctgggagt ctaattgcag ttccctgagc catgtgcctt tctcttcact     2100

gaggactgcc ccattcttga gtgccaaacg tcactagtaa cagggtgtgc ctagataatt     2160

tatgatccaa actgagtcag tttggaaagt gaaagggaaa cttacatata atccctccgg     2220

gacaatgagc aaaaactagg actgtcccca gacaaatgtg aacatacata tcatcactta     2280

aattaaaatg gctatgagaa agaaagaggg ggagaaacag tcttgcgggt gtgaagtccc     2340

atgaccagcc atgtcaaaag aaggtaaaga agtcaagaaa aagccatgaa gcccatttgg     2400

tttcattttt ctgaaaatag gctcaagagg gaataaatta gaaactcaca atttctcttg     2460

tttgttacca agacagtgat tctcttgctg ctaccaccca actgcatccg tccatgatct     2520

cagaggaaac tgtcgctgac cctggacatg ggtacgtttg acgagtgaga ggaggcatga     2580

cccctcccat gtgtatagac actaccccaa cctaaattca tccctaaatt gtcccaagtt     2640

ctccagcaat agaggctgcc acaaacttca gggagaaaga gttacaagta catgcaatga     2700

gtgaactgac tgtggctaca atcttgaaga tatacggaag agacgtatta ttaatgcttg     2760

acatatatca tcttgccttt cttggtctag actgacttct aatgactaac tcaaagtcaa     2820

ggcaactgag taatgtcagc tcagcaaagt gcagcaaacc catctcccac aggcctccaa     2880

accctggctg ttcacagaac cacaaagggc agatgctgca cagaaaacta gagaaggggt     2940

cataggttca tggttttgtt tgagatttgt tgctactgtt tttctgtttt gaattttctt     3000

ctttgttctg tttttacttt atttaggggg actaggtgtt tctgatattt tagttttctt     3060

gtttgttttg ttttgtgttg tctgtgaatg gggttttaac tgtggatgaa tggaccttat     3120

ctgttggctt aaaggactgg taagatcaga ccatcttatt cttcaggtga atgttttact     3180

ttccaaagtg ctctcctctg caccagcagt aataaataca atgccataat cccttaggtt     3240

tgcctagtgc ttttgcaatt ttcaaagcac ttccataagc attccttcca cctccttgat     3300

aggcatttat ggaaagcctg ctacatgtca atcatactgt taggcacagg ggacctaaag     3360

acacataaaa ggatggcatt ctgcctcata aattgcaaaa cctaatgaaa gtgactgctt     3420

ggtaaacaaa ttattattat attataaaat gctataaaag agccatattg aaagtgccct     3480

gttggagaca gggcaaatgc cacaaaaatg atgtaaattt acatggagga aaagtagaat     3540

ctgcctggtt tgtaggcagc agaagacatt tttcatcagt gggcaggtgt tctttacctt     3600

ttgtagaaat gggagtcaag tctcaaatag gaggctccac aaaatctcat gccaggtctc     3660

tgatacctta ttcacagaag ttctttgaag tatttattgt tattttcttt gacttatggg     3720

aaaactggga cacaggaaga caggtaaatt acccaacctc acacgttaag tcagaactgg     3780

gagccataat tttgtatccc tggtataaat agacaatctc ttgaagaaat gaagagatga     3840

ccatagaaaa acatcgagat atctccagct ctaaaatcct ttgtttcaat gttgtttggc     3900

atatgttatc tttggaattt agtgtctgag cctctgtctg ttactgtagt atttaaaatg     3960

catgtattat aatcatataa tcataactgc tgttaattct tgattatata cctagggaca     4020

atgtgtaatg taagattact aattggttct gcccaatctc ctttcagatt ttattaggaa     4080

aaaaaaataa acctcctgat cggagacaat gtattaatca gaagtgtaaa ctgccagttc     4140

tatatagcat gaaatgaaaa gacagctaat ttggtccaac aaacatgact gggtctaggg     4200

cacccaggct gattcagctg atttcctacc agcctttgcc tcttccttca atgtggtttc     4260

catgggaatt tgcttcagaa aagccaagta tgggctgttc agaggtgcac acctgcattt     4320

tcttagctct tctagagggg ctaagagact tggtacgggc caggaagaat atgtggcaga     4380

gctcctggaa atgatgcaga ttaggtggca tttttgtcag ctctgtggtt tattgttggg     4440

actattcttt aaaatatcca ttgttcacta cagtgaagat ctctgattta accgtgtact     4500

atccacatgc attacaaaca tttcgcagag ctgcttagta tataagcgta caatgtatgt     4560

aataaccatc tcatatttaa ttaaatggta tagaagaaca aaaaaaaaaa aaaaaaa        4617


<210>  6
<211>  459
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Thr Ile Leu Gly Thr Thr Phe Gly Met Val Phe Ser Leu Leu Gln 
1               5                   10                  15      


Val Val Ser Gly Glu Ser Gly Tyr Ala Gln Asn Gly Asp Leu Glu Asp 
            20                  25                  30          


Ala Glu Leu Asp Asp Tyr Ser Phe Ser Cys Tyr Ser Gln Leu Glu Val 
        35                  40                  45              


Asn Gly Ser Gln His Ser Leu Thr Cys Ala Phe Glu Asp Pro Asp Val 
    50                  55                  60                  


Asn Ile Thr Asn Leu Glu Phe Glu Ile Cys Gly Ala Leu Val Glu Val 
65                  70                  75                  80  


Lys Cys Leu Asn Phe Arg Lys Leu Gln Glu Ile Tyr Phe Ile Glu Thr 
                85                  90                  95      


Lys Lys Phe Leu Leu Ile Gly Lys Ser Asn Ile Cys Val Lys Val Gly 
            100                 105                 110         


Glu Lys Ser Leu Thr Cys Lys Lys Ile Asp Leu Thr Thr Ile Val Lys 
        115                 120                 125             


Pro Glu Ala Pro Phe Asp Leu Ser Val Val Tyr Arg Glu Gly Ala Asn 
    130                 135                 140                 


Asp Phe Val Val Thr Phe Asn Thr Ser His Leu Gln Lys Lys Tyr Val 
145                 150                 155                 160 


Lys Val Leu Met His Asp Val Ala Tyr Arg Gln Glu Lys Asp Glu Asn 
                165                 170                 175     


Lys Trp Thr His Val Asn Leu Ser Ser Thr Lys Leu Thr Leu Leu Gln 
            180                 185                 190         


Arg Lys Leu Gln Pro Ala Ala Met Tyr Glu Ile Lys Val Arg Ser Ile 
        195                 200                 205             


Pro Asp His Tyr Phe Lys Gly Phe Trp Ser Glu Trp Ser Pro Ser Tyr 
    210                 215                 220                 


Tyr Phe Arg Thr Pro Glu Ile Asn Asn Ser Ser Gly Glu Met Asp Pro 
225                 230                 235                 240 


Ile Leu Leu Thr Ile Ser Ile Leu Ser Phe Phe Ser Val Ala Leu Leu 
                245                 250                 255     


Val Ile Leu Ala Cys Val Leu Trp Lys Lys Arg Ile Lys Pro Ile Val 
            260                 265                 270         


Trp Pro Ser Leu Pro Asp His Lys Lys Thr Leu Glu His Leu Cys Lys 
        275                 280                 285             


Lys Pro Arg Lys Asn Leu Asn Val Ser Phe Asn Pro Glu Ser Phe Leu 
    290                 295                 300                 


Asp Cys Gln Ile His Arg Val Asp Asp Ile Gln Ala Arg Asp Glu Val 
305                 310                 315                 320 


Glu Gly Phe Leu Gln Asp Thr Phe Pro Gln Gln Leu Glu Glu Ser Glu 
                325                 330                 335     


Lys Gln Arg Leu Gly Gly Asp Val Gln Ser Pro Asn Cys Pro Ser Glu 
            340                 345                 350         


Asp Val Val Ile Thr Pro Glu Ser Phe Gly Arg Asp Ser Ser Leu Thr 
        355                 360                 365             


Cys Leu Ala Gly Asn Val Ser Ala Cys Asp Ala Pro Ile Leu Ser Ser 
    370                 375                 380                 


Ser Arg Ser Leu Asp Cys Arg Glu Ser Gly Lys Asn Gly Pro His Val 
385                 390                 395                 400 


Tyr Gln Asp Leu Leu Leu Ser Leu Gly Thr Thr Asn Ser Thr Leu Pro 
                405                 410                 415     


Pro Pro Phe Ser Leu Gln Ser Gly Ile Leu Thr Leu Asn Pro Val Ala 
            420                 425                 430         


Gln Gly Gln Pro Ile Leu Thr Ser Leu Gly Ser Asn Gln Glu Glu Ala 
        435                 440                 445             


Tyr Val Thr Met Ser Ser Phe Tyr Gln Asn Gln 
    450                 455                 


<210>  7
<211>  6582
<212>  DNA
<213>  Homo sapiens

<400>  7
agagggcaag gagagagcag agaacacact ttgccttctc tttggtattg agtaatatca       60

accaaattgc agacatctca acactttggc caggcagcct gctgagcaag gtacctcagc      120

cagcatggca gcctctttcc cacccacctt gggactcagt tctgccccag atgaaattca      180

gcacccacat attaaatttt cagaatggaa atttaagctg ttccgggtga gatcctttga      240

aaagacacct gaagaagctc aaaaggaaaa gaaggattcc tttgagggga aaccctctct      300

ggagcaatct ccagcagtcc tggacaaggc tgatggtcag aagccagtcc caactcagcc      360

attgttaaaa gcccacccta agttttcaaa gaaatttcac gacaacgaga aagcaagagg      420

caaagcgatc catcaagcca accttcgaca tctctgccgc atctgtggga attcttttag      480

agctgatgag cacaacagga gatatccagt ccatggtcct gtggatggta aaaccctagg      540

ccttttacga aagaaggaaa agagagctac ttcctggccg gacctcattg ccaaggtttt      600

ccggatcgat gtgaaggcag atgttgactc gatccacccc actgagttct gccataactg      660

ctggagcatc atgcacagga agtttagcag tgccccatgt gaggtttact tcccgaggaa      720

cgtgaccatg gagtggcacc cccacacacc atcctgtgac atctgcaaca ctgcccgtcg      780

gggactcaag aggaagagtc ttcagccaaa cttgcagctc agcaaaaaac tcaaaactgt      840

gcttgaccaa gcaagacaag cccgtcagcg caagagaaga gctcaggcaa ggatcagcag      900

caaggatgtc atgaagaaga tcgccaactg cagtaagata catcttagta ccaagctcct      960

tgcagtggac ttcccagagc actttgtgaa atccatctcc tgccagatct gtgaacacat     1020

tctggctgac cctgtggaga ccaactgtaa gcatgtcttt tgccgggtct gcattctcag     1080

atgcctcaaa gtcatgggca gctattgtcc ctcttgccga tatccatgct tccctactga     1140

cctggagagt ccagtgaagt cctttctgag cgtcttgaat tccctgatgg tgaaatgtcc     1200

agcaaaagag tgcaatgagg aggtcagttt ggaaaaatat aatcaccaca tctcaagtca     1260

caaggaatca aaagagattt ttgtgcacat taataaaggg ggccggcccc gccaacatct     1320

tctgtcgctg actcggagag ctcagaagca ccggctgagg gagctcaagc tgcaagtcaa     1380

agcctttgct gacaaagaag aaggtggaga tgtgaagtcc gtgtgcatga ccttgttcct     1440

gctggctctg agggcgagga atgagcacag gcaagctgat gagctggagg ccatcatgca     1500

gggaaagggc tctggcctgc agccagctgt ttgcttggcc atccgtgtca acaccttcct     1560

cagctgcagt cagtaccaca agatgtacag gactgtgaaa gccatcacag ggagacagat     1620

ttttcagcct ttgcatgccc ttcggaatgc tgagaaggta cttctgccag gctaccacca     1680

ctttgagtgg cagccacctc tgaagaatgt gtcttccagc actgatgttg gcattattga     1740

tgggctgtct ggactatcat cctctgtgga tgattaccca gtggacacca ttgcaaagag     1800

gttccgctat gattcagctt tggtgtctgc tttgatggac atggaagaag acatcttgga     1860

aggcatgaga tcccaagacc ttgatgatta cctgaatggc cccttcactg tggtggtgaa     1920

ggagtcttgt gatggaatgg gagacgtgag tgagaagcat gggagtgggc ctgtagttcc     1980

agaaaaggca gtccgttttt cattcacaat catgaaaatt actattgccc acagctctca     2040

gaatgtgaaa gtatttgaag aagccaaacc taactctgaa ctgtgttgca agccattgtg     2100

ccttatgctg gcagatgagt ctgaccacga gacgctgact gccatcctga gtcctctcat     2160

tgctgagagg gaggccatga agagcagtga attaatgctt gagctgggag gcattctccg     2220

gactttcaag ttcatcttca ggggcaccgg ctatgatgaa aaacttgtgc gggaagtgga     2280

aggcctcgag gcttctggct cagtctacat ttgtactctt tgtgatgcca cccgtctgga     2340

agcctctcaa aatcttgtct tccactctat aaccagaagc catgctgaga acctggaacg     2400

ttatgaggtc tggcgttcca acccttacca tgagtctgtg gaagaactgc gggatcgggt     2460

gaaaggggtc tcagctaaac ctttcattga gacagtccct tccatagatg cactccactg     2520

tgacattggc aatgcagctg agttctacaa gatcttccag ctagagatag gggaagtgta     2580

taagaatccc aatgcttcca aagaggaaag gaaaaggtgg caggccacac tggacaagca     2640

tctccggaag aagatgaacc tcaaaccaat catgaggatg aatggcaact ttgccaggaa     2700

gctcatgacc aaagagactg tggatgcagt ttgtgagtta attccttccg aggagaggca     2760

cgaggctctg agggagctga tggatcttta cctgaagatg aaaccagtat ggcgatcatc     2820

atgccctgct aaagagtgcc cagaatccct ctgccagtac agtttcaatt cacagcgttt     2880

tgctgagctc ctttctacga agttcaagta taggtatgag ggaaaaatca ccaattattt     2940

tcacaaaacc ctggcccatg ttcctgaaat tattgagagg gatggctcca ttggggcatg     3000

ggcaagtgag ggaaatgagt ctggtaacaa actgtttagg cgcttccgga aaatgaatgc     3060

caggcagtcc aaatgctatg agatggaaga tgtcctgaaa caccactggt tgtacacctc     3120

caaatacctc cagaagttta tgaatgctca taatgcatta aaaacctctg ggtttaccat     3180

gaaccctcag gcaagcttag gggacccatt aggcatagag gactctctgg aaagccaaga     3240

ttcaatggaa ttttaagtag ggcaaccact tatgagttgg tttttgcaat tgagtttccc     3300

tctgggttgc attgagggct tctcctagca ccctttactg ctgtgtatgg ggcttcacca     3360

tccaagaggt ggtaggttgg agtaagatgc tacagatgct ctcaagtcag gaatagaaac     3420

tgatgagctg attgcttgag gcttttagtg agttccgaaa agcaacagga aaaatcagtt     3480

atctgaaagc tcagtaactc agaacaggag taactgcagg ggaccagaga tgagcaaaga     3540

tctgtgtgtg ttggggagct gtcatgtaaa tcaaagccaa ggttgtcaaa gaacagccag     3600

tgaggccagg aaagaaattg gtcttgtggt tttcattttt ttcccccttg attgattata     3660

ttttgtattg agatatgata agtgccttct atttcatttt tgaataattc ttcattttta     3720

taattttaca tatcttggct tgctatataa gattcaaaag agctttttaa atttttctaa     3780

taatatctta catttgtaca gcatgatgac ctttacaaag tgctctcaat gcatttaccc     3840

attcgttata taaatatgtt acatcaggac aactttgaga aaatcagtcc ttttttatgt     3900

ttaaattatg tatctattgt aaccttcaga gtttaggagg tcatctgctg tcatggattt     3960

ttcaataatg aatttagaat acacctgtta gctacagtta gttattaaat cttctgataa     4020

tatatgttta cttagctatc agaagccaag tatgattctt tatttttact ttttcatttc     4080

aagaaattta gagtttccaa atttagagct tctgcataca gtcttaaagc cacagaggct     4140

tgtaaaaata taggttagct tgatgtctaa aaatatattt catgtcttac tgaaacattt     4200

tgccagactt tctccaaatg aaacctgaat caatttttct aaatctaggt ttcatagagt     4260

cctctcctct gcaatgtgtt attctttcta taatgatcag tttactttca gtggattcag     4320

aattgtgtag caggataacc ttgtattttt ccatccgcta agtttagatg gagtccaaac     4380

gcagtacagc agaagagtta acatttacac agtgcttttt accactgtgg aatgttttca     4440

cactcatttt tccttacaac aattctgagg agtaggtgtt gttattatct ccatttgatg     4500

ggggtttaaa tgatttgctc aaagtcattt aggggtaata aatacttggc ttggaaattt     4560

aacacagtcc ttttgtctcc aaagcccttc ttctttccac cacaaattaa tcactatgtt     4620

tataaggtag tatcagaatt tttttaggat tcacaactaa tcactatagc acatgacctt     4680

gggattacat ttttatgggg caggggtaag caagttttta aatcatttgt gtgctctggc     4740

tcttttgata gaagaaagca acacaaaagc tccaaagggc cccctaaccc tcttgtggct     4800

ccagttattt ggaaactatg atctgcatcc ttaggaatct gggatttgcc agttgctggc     4860

aatgtagagc aggcatggaa ttttatatgc tagtgagtca taatgatatg ttagtgttaa     4920

ttagtttttt cttcctttga ttttattggc cataattgct actcttcata cacagtatat     4980

caaagagctt gataatttag ttgtcaaaag tgcatcggcg acattatctt taattgtatg     5040

tatttggtgc ttcttcaggg attgaactca gtatctttca ttaaaaaaca cagcagtttt     5100

ccttgctttt tatatgcaga atatcaaagt catttctaat ttagttgtca aaaacatata     5160

catattttaa cattagtttt tttgaaaact cttggttttg tttttttgga aatgagtggg     5220

ccactaagcc acactttccc ttcatcctgc ttaatccttc cagcatgtct ctgcactaat     5280

aaacagctaa attcacataa tcatcctatt tactgaagca tggtcatgct ggtttataga     5340

ttttttaccc atttctactc tttttctcta ttggtggcac tgtaaatact ttccagtatt     5400

aaattatcct tttctaacac tgtaggaact attttgaatg catgtgacta agagcatgat     5460

ttatagcaca acctttccaa taatccctta atcagatcac attttgataa accctgggaa     5520

catctggctg caggaatttc aatatgtaga aacgctgcct atggtttttt gcccttactg     5580

ttgagactgc aatatcctag accctagttt tatactagag ttttattttt agcaatgcct     5640

attgcaagtg caattatata ctccagggaa attcaccaca ctgaatcgag catttgtgtg     5700

tgtatgtgtg aagtatatac tgggacttca gaagtgcaat gtatttttct cctgtgaaac     5760

ctgaatctac aagttttcct gccaagccac tcaggtgcat tgcagggacc agtgataatg     5820

gctgatgaaa attgatgatt ggtcagtgag gtcaaaagga gccttgggat taataaacat     5880

gcactgagaa gcaagaggag gagaaaaaga tgtctttttc ttccaggtga actggaattt     5940

agttttgcct cagatttttt tcccacaaga tacagaagaa gataaagatt tttttggttg     6000

agagtgtggg tcttgcatta catcaaacag agttcaaatt ccacacagat aagaggcagg     6060

atatataagc gccagtggta gttgggagga ataaaccatt atttggatgc aggtggtttt     6120

tgattgcaaa tatgtgtgtg tcttcagtga ttgtatgaca gatgatgtat tcttttgatg     6180

ttaaaagatt ttaagtaaga gtagatacat tgtacccatt ttacattttc ttattttaac     6240

tacagtaatc tacataaata tacctcagaa atcatttttg gtgattattt tttgttttgt     6300

agaattgcac ttcagtttat tttcttacaa ataaccttac attttgttta atggcttcca     6360

agagcctttt ttttttttgt atttcagaga aaattcaggt accaggatgc aatggattta     6420

tttgattcag gggacctgtg tttccatgtc aaatgttttc aaataaaatg aaatatgagt     6480

ttcaatactt tttatatttt aatatttcca ttcattaata ttatggttat tgtcagcaat     6540

tttatgtttg aatatttgaa ataaaagttt aagatttgaa aa                        6582


<210>  8
<211>  1043
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Ala Ala Ser Phe Pro Pro Thr Leu Gly Leu Ser Ser Ala Pro Asp 
1               5                   10                  15      


Glu Ile Gln His Pro His Ile Lys Phe Ser Glu Trp Lys Phe Lys Leu 
            20                  25                  30          


Phe Arg Val Arg Ser Phe Glu Lys Thr Pro Glu Glu Ala Gln Lys Glu 
        35                  40                  45              


Lys Lys Asp Ser Phe Glu Gly Lys Pro Ser Leu Glu Gln Ser Pro Ala 
    50                  55                  60                  


Val Leu Asp Lys Ala Asp Gly Gln Lys Pro Val Pro Thr Gln Pro Leu 
65                  70                  75                  80  


Leu Lys Ala His Pro Lys Phe Ser Lys Lys Phe His Asp Asn Glu Lys 
                85                  90                  95      


Ala Arg Gly Lys Ala Ile His Gln Ala Asn Leu Arg His Leu Cys Arg 
            100                 105                 110         


Ile Cys Gly Asn Ser Phe Arg Ala Asp Glu His Asn Arg Arg Tyr Pro 
        115                 120                 125             


Val His Gly Pro Val Asp Gly Lys Thr Leu Gly Leu Leu Arg Lys Lys 
    130                 135                 140                 


Glu Lys Arg Ala Thr Ser Trp Pro Asp Leu Ile Ala Lys Val Phe Arg 
145                 150                 155                 160 


Ile Asp Val Lys Ala Asp Val Asp Ser Ile His Pro Thr Glu Phe Cys 
                165                 170                 175     


His Asn Cys Trp Ser Ile Met His Arg Lys Phe Ser Ser Ala Pro Cys 
            180                 185                 190         


Glu Val Tyr Phe Pro Arg Asn Val Thr Met Glu Trp His Pro His Thr 
        195                 200                 205             


Pro Ser Cys Asp Ile Cys Asn Thr Ala Arg Arg Gly Leu Lys Arg Lys 
    210                 215                 220                 


Ser Leu Gln Pro Asn Leu Gln Leu Ser Lys Lys Leu Lys Thr Val Leu 
225                 230                 235                 240 


Asp Gln Ala Arg Gln Ala Arg Gln Arg Lys Arg Arg Ala Gln Ala Arg 
                245                 250                 255     


Ile Ser Ser Lys Asp Val Met Lys Lys Ile Ala Asn Cys Ser Lys Ile 
            260                 265                 270         


His Leu Ser Thr Lys Leu Leu Ala Val Asp Phe Pro Glu His Phe Val 
        275                 280                 285             


Lys Ser Ile Ser Cys Gln Ile Cys Glu His Ile Leu Ala Asp Pro Val 
    290                 295                 300                 


Glu Thr Asn Cys Lys His Val Phe Cys Arg Val Cys Ile Leu Arg Cys 
305                 310                 315                 320 


Leu Lys Val Met Gly Ser Tyr Cys Pro Ser Cys Arg Tyr Pro Cys Phe 
                325                 330                 335     


Pro Thr Asp Leu Glu Ser Pro Val Lys Ser Phe Leu Ser Val Leu Asn 
            340                 345                 350         


Ser Leu Met Val Lys Cys Pro Ala Lys Glu Cys Asn Glu Glu Val Ser 
        355                 360                 365             


Leu Glu Lys Tyr Asn His His Ile Ser Ser His Lys Glu Ser Lys Glu 
    370                 375                 380                 


Ile Phe Val His Ile Asn Lys Gly Gly Arg Pro Arg Gln His Leu Leu 
385                 390                 395                 400 


Ser Leu Thr Arg Arg Ala Gln Lys His Arg Leu Arg Glu Leu Lys Leu 
                405                 410                 415     


Gln Val Lys Ala Phe Ala Asp Lys Glu Glu Gly Gly Asp Val Lys Ser 
            420                 425                 430         


Val Cys Met Thr Leu Phe Leu Leu Ala Leu Arg Ala Arg Asn Glu His 
        435                 440                 445             


Arg Gln Ala Asp Glu Leu Glu Ala Ile Met Gln Gly Lys Gly Ser Gly 
    450                 455                 460                 


Leu Gln Pro Ala Val Cys Leu Ala Ile Arg Val Asn Thr Phe Leu Ser 
465                 470                 475                 480 


Cys Ser Gln Tyr His Lys Met Tyr Arg Thr Val Lys Ala Ile Thr Gly 
                485                 490                 495     


Arg Gln Ile Phe Gln Pro Leu His Ala Leu Arg Asn Ala Glu Lys Val 
            500                 505                 510         


Leu Leu Pro Gly Tyr His His Phe Glu Trp Gln Pro Pro Leu Lys Asn 
        515                 520                 525             


Val Ser Ser Ser Thr Asp Val Gly Ile Ile Asp Gly Leu Ser Gly Leu 
    530                 535                 540                 


Ser Ser Ser Val Asp Asp Tyr Pro Val Asp Thr Ile Ala Lys Arg Phe 
545                 550                 555                 560 


Arg Tyr Asp Ser Ala Leu Val Ser Ala Leu Met Asp Met Glu Glu Asp 
                565                 570                 575     


Ile Leu Glu Gly Met Arg Ser Gln Asp Leu Asp Asp Tyr Leu Asn Gly 
            580                 585                 590         


Pro Phe Thr Val Val Val Lys Glu Ser Cys Asp Gly Met Gly Asp Val 
        595                 600                 605             


Ser Glu Lys His Gly Ser Gly Pro Val Val Pro Glu Lys Ala Val Arg 
    610                 615                 620                 


Phe Ser Phe Thr Ile Met Lys Ile Thr Ile Ala His Ser Ser Gln Asn 
625                 630                 635                 640 


Val Lys Val Phe Glu Glu Ala Lys Pro Asn Ser Glu Leu Cys Cys Lys 
                645                 650                 655     


Pro Leu Cys Leu Met Leu Ala Asp Glu Ser Asp His Glu Thr Leu Thr 
            660                 665                 670         


Ala Ile Leu Ser Pro Leu Ile Ala Glu Arg Glu Ala Met Lys Ser Ser 
        675                 680                 685             


Glu Leu Met Leu Glu Leu Gly Gly Ile Leu Arg Thr Phe Lys Phe Ile 
    690                 695                 700                 


Phe Arg Gly Thr Gly Tyr Asp Glu Lys Leu Val Arg Glu Val Glu Gly 
705                 710                 715                 720 


Leu Glu Ala Ser Gly Ser Val Tyr Ile Cys Thr Leu Cys Asp Ala Thr 
                725                 730                 735     


Arg Leu Glu Ala Ser Gln Asn Leu Val Phe His Ser Ile Thr Arg Ser 
            740                 745                 750         


His Ala Glu Asn Leu Glu Arg Tyr Glu Val Trp Arg Ser Asn Pro Tyr 
        755                 760                 765             


His Glu Ser Val Glu Glu Leu Arg Asp Arg Val Lys Gly Val Ser Ala 
    770                 775                 780                 


Lys Pro Phe Ile Glu Thr Val Pro Ser Ile Asp Ala Leu His Cys Asp 
785                 790                 795                 800 


Ile Gly Asn Ala Ala Glu Phe Tyr Lys Ile Phe Gln Leu Glu Ile Gly 
                805                 810                 815     


Glu Val Tyr Lys Asn Pro Asn Ala Ser Lys Glu Glu Arg Lys Arg Trp 
            820                 825                 830         


Gln Ala Thr Leu Asp Lys His Leu Arg Lys Lys Met Asn Leu Lys Pro 
        835                 840                 845             


Ile Met Arg Met Asn Gly Asn Phe Ala Arg Lys Leu Met Thr Lys Glu 
    850                 855                 860                 


Thr Val Asp Ala Val Cys Glu Leu Ile Pro Ser Glu Glu Arg His Glu 
865                 870                 875                 880 


Ala Leu Arg Glu Leu Met Asp Leu Tyr Leu Lys Met Lys Pro Val Trp 
                885                 890                 895     


Arg Ser Ser Cys Pro Ala Lys Glu Cys Pro Glu Ser Leu Cys Gln Tyr 
            900                 905                 910         


Ser Phe Asn Ser Gln Arg Phe Ala Glu Leu Leu Ser Thr Lys Phe Lys 
        915                 920                 925             


Tyr Arg Tyr Glu Gly Lys Ile Thr Asn Tyr Phe His Lys Thr Leu Ala 
    930                 935                 940                 


His Val Pro Glu Ile Ile Glu Arg Asp Gly Ser Ile Gly Ala Trp Ala 
945                 950                 955                 960 


Ser Glu Gly Asn Glu Ser Gly Asn Lys Leu Phe Arg Arg Phe Arg Lys 
                965                 970                 975     


Met Asn Ala Arg Gln Ser Lys Cys Tyr Glu Met Glu Asp Val Leu Lys 
            980                 985                 990         


His His Trp Leu Tyr Thr Ser Lys  Tyr Leu Gln Lys Phe  Met Asn Ala 
        995                 1000                 1005             


His Asn  Ala Leu Lys Thr Ser  Gly Phe Thr Met Asn  Pro Gln Ala 
    1010                 1015                 1020             


Ser Leu  Gly Asp Pro Leu Gly  Ile Glu Asp Ser Leu  Glu Ser Gln 
    1025                 1030                 1035             


Asp Ser  Met Glu Phe 
    1040             


<210>  9
<211>  2457
<212>  DNA
<213>  Homo sapiens

<400>  9
attagatcag tgttcataag aacatctgta ggcacacata cacactctct ttacagtcag       60

ccttctgctt gccacagtca tagtgggcag tcagtgaatc ttccccaagt gctgacaatt      120

aatacctggt ttagcggcaa agattcagag aggcgtgagc agcccctctg gccttcagac      180

aaaaatctac gtaccatcag aaactatgtc tctgcagatg gtaacagtca gtaataacat      240

agccttaatt cagccaggct tctcactgat gaattttgat ggacaagttt tcttctttgg      300

acaaaaaggc tggcccaaaa gatcctgccc cactggagtt ttccatctgg atgtaaagca      360

taaccatgtc aaactgaagc ctacaatttt ctctaaggat tcctgctacc tccctcctct      420

tcgctaccca gccacttgca cattcaaagg cagcttggag tctgaaaagc atcaatacat      480

catccatgga gggaaaacac caaacaatga ggtttcagat aagatttatg tcatgtctat      540

tgtttgcaag aacaacaaaa aggttacttt tcgctgcaca gagaaagact tggtaggaga      600

tgttcctgaa gccagatatg gtcattccat taatgtggtg tacagccgag ggaaaagtat      660

gggtgttctc tttggaggac gctcatacat gccttctacc cacagaacca cagaaaaatg      720

gaatagtgta gctgactgcc tgccctgtgt tttcctggtg gattttgaat ttgggtgtgc      780

tacatcatac attcttccag aacttcagga tgggctatct tttcatgtct ctattgccaa      840

aaatgacacc atctatattt taggaggaca ttcacttgcc aataatatcc ggcctgccaa      900

cctgtacaga ataagggttg atcttcccct gggtagccca gctgtgaatt gcacagtctt      960

gccaggagga atctctgtct ccagtgcaat cctgactcaa actaacaatg atgaatttgt     1020

tattgttggt ggctatcagc ttgaaaatca aaaaagaatg atctgcaaca tcatctcttt     1080

agaggacaac aagatagaaa ttcgtgagat ggagacccca gattggaccc cagacattaa     1140

gcacagcaag atatggtttg gaagcaacat gggaaatgga actgtttttc ttggcatacc     1200

aggagacaat aaacaagttg tttcagaagg attctatttc tatatgttga aatgtgctga     1260

agatgatact aatgaagagc agacaacatt cacaaacagt caaacatcaa cagaagatcc     1320

aggggattcc actccctttg aagactctga agaattttgt ttcagtgcag aagcaaatag     1380

ttttgatggt gatgatgaat ttgacaccta taatgaagat gatgaagaag atgagtctga     1440

gacaggctac tggattacat gctgccctac ttgtgatgtg gatatcaaca cttgggtacc     1500

attctattca actgagctca acaaacccgc catgatctac tgctctcatg gggatgggca     1560

ctgggtccat gctcagtgca tggatctggc agaacgcaca ctcatccatc tgtcagcagg     1620

aagcaacaag tattactgca atgagcatgt ggagatagca agagctctac acactcccca     1680

aagagtccta cccttaaaaa agcctccaat gaaatccctc cgtaaaaaag gttctggaaa     1740

aatcttgact cctgccaaga aatcctttct tagaaggttg tttgattagt tttgcaaaag     1800

cctttcagat tcaggtgtat ggaatttttg aatctatttt taaaatcata acattgattt     1860

taaaaataca tttttgttta tttaaaatgc ctatgttttc ttttagttac atgaattaag     1920

ggccagaaaa aagtgtttat aatgcaatga taaataaagt cattctagac cctatacatt     1980

ttgaaaatat tttacccaaa tactcaattt actaatttat tcttcactga ggatttctga     2040

tctgattttt tattcaacaa accttaaaca cccagaagca gtaataatca tcgaggtatg     2100

tttatattta ttatataagt cttggtaaca aataacctat aaagtgttta tgacaaattt     2160

agccaataaa gaaattaaca cccaaaagaa ttaaattgat tattttgtgc aacataacaa     2220

ttcggcagtt ggccaaaact taaaagcaag atctactaca tcccacatta gtgttcttta     2280

tataccttca agcaaccctt tggattatgc ccatgaacaa gttagtttct catagcttta     2340

cagatgtaga tataaatata aatatatgta tacatataga tagataatgt tctccactga     2400

cacaaaagaa gaaataaata atctacatca aaaaaaaaaa aaaaaaaaaa aaaaaaa        2457


<210>  10
<211>  527
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Ser Leu Gln Met Val Thr Val Ser Asn Asn Ile Ala Leu Ile Gln 
1               5                   10                  15      


Pro Gly Phe Ser Leu Met Asn Phe Asp Gly Gln Val Phe Phe Phe Gly 
            20                  25                  30          


Gln Lys Gly Trp Pro Lys Arg Ser Cys Pro Thr Gly Val Phe His Leu 
        35                  40                  45              


Asp Val Lys His Asn His Val Lys Leu Lys Pro Thr Ile Phe Ser Lys 
    50                  55                  60                  


Asp Ser Cys Tyr Leu Pro Pro Leu Arg Tyr Pro Ala Thr Cys Thr Phe 
65                  70                  75                  80  


Lys Gly Ser Leu Glu Ser Glu Lys His Gln Tyr Ile Ile His Gly Gly 
                85                  90                  95      


Lys Thr Pro Asn Asn Glu Val Ser Asp Lys Ile Tyr Val Met Ser Ile 
            100                 105                 110         


Val Cys Lys Asn Asn Lys Lys Val Thr Phe Arg Cys Thr Glu Lys Asp 
        115                 120                 125             


Leu Val Gly Asp Val Pro Glu Ala Arg Tyr Gly His Ser Ile Asn Val 
    130                 135                 140                 


Val Tyr Ser Arg Gly Lys Ser Met Gly Val Leu Phe Gly Gly Arg Ser 
145                 150                 155                 160 


Tyr Met Pro Ser Thr His Arg Thr Thr Glu Lys Trp Asn Ser Val Ala 
                165                 170                 175     


Asp Cys Leu Pro Cys Val Phe Leu Val Asp Phe Glu Phe Gly Cys Ala 
            180                 185                 190         


Thr Ser Tyr Ile Leu Pro Glu Leu Gln Asp Gly Leu Ser Phe His Val 
        195                 200                 205             


Ser Ile Ala Lys Asn Asp Thr Ile Tyr Ile Leu Gly Gly His Ser Leu 
    210                 215                 220                 


Ala Asn Asn Ile Arg Pro Ala Asn Leu Tyr Arg Ile Arg Val Asp Leu 
225                 230                 235                 240 


Pro Leu Gly Ser Pro Ala Val Asn Cys Thr Val Leu Pro Gly Gly Ile 
                245                 250                 255     


Ser Val Ser Ser Ala Ile Leu Thr Gln Thr Asn Asn Asp Glu Phe Val 
            260                 265                 270         


Ile Val Gly Gly Tyr Gln Leu Glu Asn Gln Lys Arg Met Ile Cys Asn 
        275                 280                 285             


Ile Ile Ser Leu Glu Asp Asn Lys Ile Glu Ile Arg Glu Met Glu Thr 
    290                 295                 300                 


Pro Asp Trp Thr Pro Asp Ile Lys His Ser Lys Ile Trp Phe Gly Ser 
305                 310                 315                 320 


Asn Met Gly Asn Gly Thr Val Phe Leu Gly Ile Pro Gly Asp Asn Lys 
                325                 330                 335     


Gln Val Val Ser Glu Gly Phe Tyr Phe Tyr Met Leu Lys Cys Ala Glu 
            340                 345                 350         


Asp Asp Thr Asn Glu Glu Gln Thr Thr Phe Thr Asn Ser Gln Thr Ser 
        355                 360                 365             


Thr Glu Asp Pro Gly Asp Ser Thr Pro Phe Glu Asp Ser Glu Glu Phe 
    370                 375                 380                 


Cys Phe Ser Ala Glu Ala Asn Ser Phe Asp Gly Asp Asp Glu Phe Asp 
385                 390                 395                 400 


Thr Tyr Asn Glu Asp Asp Glu Glu Asp Glu Ser Glu Thr Gly Tyr Trp 
                405                 410                 415     


Ile Thr Cys Cys Pro Thr Cys Asp Val Asp Ile Asn Thr Trp Val Pro 
            420                 425                 430         


Phe Tyr Ser Thr Glu Leu Asn Lys Pro Ala Met Ile Tyr Cys Ser His 
        435                 440                 445             


Gly Asp Gly His Trp Val His Ala Gln Cys Met Asp Leu Ala Glu Arg 
    450                 455                 460                 


Thr Leu Ile His Leu Ser Ala Gly Ser Asn Lys Tyr Tyr Cys Asn Glu 
465                 470                 475                 480 


His Val Glu Ile Ala Arg Ala Leu His Thr Pro Gln Arg Val Leu Pro 
                485                 490                 495     


Leu Lys Lys Pro Pro Met Lys Ser Leu Arg Lys Lys Gly Ser Gly Lys 
            500                 505                 510         


Ile Leu Thr Pro Ala Lys Lys Ser Phe Leu Arg Arg Leu Phe Asp 
        515                 520                 525         


<210>  11
<211>  2450
<212>  DNA
<213>  Homo sapiens

<400>  11
aataggttag tttcagacaa gcctgcttgc cggagctcag cagacaccag gccttccggg       60

caggcctggc ccaccgtggg cctcagagct gctgctgggg cattcagaac cggctctcca      120

ttggcattgg gaccagagac cccgcaagtg gcctgtttgc ctggacatcc acctgtacgt      180

ccccaggttt cgggaggccc aggggcgatg ccagaccccg cggcgcacct gcccttcttc      240

tacggcagca tctcgcgtgc cgaggccgag gagcacctga agctggcggg catggcggac      300

gggctcttcc tgctgcgcca gtgcctgcgc tcgctgggcg gctatgtgct gtcgctcgtg      360

cacgatgtgc gcttccacca ctttcccatc gagcgccagc tcaacggcac ctacgccatt      420

gccggcggca aagcgcactg tggaccggca gagctctgcg agttctactc gcgcgacccc      480

gacgggctgc cctgcaacct gcgcaagccg tgcaaccggc cgtcgggcct cgagccgcag      540

ccgggggtct tcgactgcct gcgagacgcc atggtgcgtg actacgtgcg ccagacgtgg      600

aagctggagg gcgaggccct ggagcaggcc atcatcagcc aggccccgca ggtggagaag      660

ctcattgcta cgacggccca cgagcggatg ccctggtacc acagcagcct gacgcgtgag      720

gaggccgagc gcaaacttta ctctggggcg cagaccgacg gcaagttcct gctgaggccg      780

cggaaggagc agggcacata cgccctgtcc ctcatctatg ggaagacggt gtaccactac      840

ctcatcagcc aagacaaggc gggcaagtac tgcattcccg agggcaccaa gtttgacacg      900

ctctggcagc tggtggagta tctgaagctg aaggcggacg ggctcatcta ctgcctgaag      960

gaggcctgcc ccaacagcag tgccagcaac gcctcagggg ctgctgctcc cacactccca     1020

gcccacccat ccacgttgac tcatcctcag agacgaatcg acaccctcaa ctcagatgga     1080

tacacccctg agccagcacg cataacgtcc ccagacaaac cgcggccgat gcccatggac     1140

acgagcgtgt atgagagccc ctacagcgac ccagaggagc tcaaggacaa gaagctcttc     1200

ctgaagcgcg ataacctcct catagctgac attgaacttg gctgcggcaa ctttggctca     1260

gtgcgccagg gcgtgtaccg catgcgcaag aagcagatcg acgtggccat caaggtgctg     1320

aagcagggca cggagaaggc agacacggaa gagatgatgc gcgaggcgca gatcatgcac     1380

cagctggaca acccctacat cgtgcggctc attggcgtct gccaggccga ggccctcatg     1440

ctggtcatgg agatggctgg gggcgggccg ctgcacaagt tcctggtcgg caagagggag     1500

gagatccctg tgagcaatgt ggccgagctg ctgcaccagg tgtccatggg gatgaagtac     1560

ctggaggaga agaactttgt gcaccgtgac ctggcggccc gcaacgtcct gctggttaac     1620

cggcactacg ccaagatcag cgactttggc ctctccaaag cactgggtgc cgacgacagc     1680

tactacactg cccgctcagc agggaagtgg ccgctcaagt ggtacgcacc cgaatgcatc     1740

aacttccgca agttctccag ccgcagcgat gtctggagct atggggtcac catgtgggag     1800

gccttgtcct acggccagaa gccctacaag aagatgaaag ggccggaggt catggccttc     1860

atcgagcagg gcaagcggat ggagtgccca ccagagtgtc cacccgaact gtacgcactc     1920

atgagtgact gctggatcta caagtgggag gatcgccccg acttcctgac cgtggagcag     1980

cgcatgcgag cctgttacta cagcctggcc agcaaggtgg aagggccccc aggcagcaca     2040

cagaaggctg aggctgcctg tgcctgagct cccgctgccc aggggagccc tccacgccgg     2100

ctcttcccca ccctcagccc caccccaggt cctgcagtct ggctgagccc tgcttggttg     2160

tctccacaca cagctgggct gtggtagggg gtgtctcagg ccacaccggc cttgcattgc     2220

ctgcctggcc ccctgtcctc tctggctggg gagcagggag gtccgggagg gtgcggctgt     2280

gcagcctgtc ctgggctggt ggctcccgga gggccctgag ctgagggcat tgcttacacg     2340

gatgccttcc cctgggccct gacattggag cctgggcatc ctcaggtggt caggcgtaga     2400

tcaccagaat aaacccagct tccctcttga aaaaaaaaaa aaaaaaaaaa                2450


<210>  12
<211>  619
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Pro Asp Pro Ala Ala His Leu Pro Phe Phe Tyr Gly Ser Ile Ser 
1               5                   10                  15      


Arg Ala Glu Ala Glu Glu His Leu Lys Leu Ala Gly Met Ala Asp Gly 
            20                  25                  30          


Leu Phe Leu Leu Arg Gln Cys Leu Arg Ser Leu Gly Gly Tyr Val Leu 
        35                  40                  45              


Ser Leu Val His Asp Val Arg Phe His His Phe Pro Ile Glu Arg Gln 
    50                  55                  60                  


Leu Asn Gly Thr Tyr Ala Ile Ala Gly Gly Lys Ala His Cys Gly Pro 
65                  70                  75                  80  


Ala Glu Leu Cys Glu Phe Tyr Ser Arg Asp Pro Asp Gly Leu Pro Cys 
                85                  90                  95      


Asn Leu Arg Lys Pro Cys Asn Arg Pro Ser Gly Leu Glu Pro Gln Pro 
            100                 105                 110         


Gly Val Phe Asp Cys Leu Arg Asp Ala Met Val Arg Asp Tyr Val Arg 
        115                 120                 125             


Gln Thr Trp Lys Leu Glu Gly Glu Ala Leu Glu Gln Ala Ile Ile Ser 
    130                 135                 140                 


Gln Ala Pro Gln Val Glu Lys Leu Ile Ala Thr Thr Ala His Glu Arg 
145                 150                 155                 160 


Met Pro Trp Tyr His Ser Ser Leu Thr Arg Glu Glu Ala Glu Arg Lys 
                165                 170                 175     


Leu Tyr Ser Gly Ala Gln Thr Asp Gly Lys Phe Leu Leu Arg Pro Arg 
            180                 185                 190         


Lys Glu Gln Gly Thr Tyr Ala Leu Ser Leu Ile Tyr Gly Lys Thr Val 
        195                 200                 205             


Tyr His Tyr Leu Ile Ser Gln Asp Lys Ala Gly Lys Tyr Cys Ile Pro 
    210                 215                 220                 


Glu Gly Thr Lys Phe Asp Thr Leu Trp Gln Leu Val Glu Tyr Leu Lys 
225                 230                 235                 240 


Leu Lys Ala Asp Gly Leu Ile Tyr Cys Leu Lys Glu Ala Cys Pro Asn 
                245                 250                 255     


Ser Ser Ala Ser Asn Ala Ser Gly Ala Ala Ala Pro Thr Leu Pro Ala 
            260                 265                 270         


His Pro Ser Thr Leu Thr His Pro Gln Arg Arg Ile Asp Thr Leu Asn 
        275                 280                 285             


Ser Asp Gly Tyr Thr Pro Glu Pro Ala Arg Ile Thr Ser Pro Asp Lys 
    290                 295                 300                 


Pro Arg Pro Met Pro Met Asp Thr Ser Val Tyr Glu Ser Pro Tyr Ser 
305                 310                 315                 320 


Asp Pro Glu Glu Leu Lys Asp Lys Lys Leu Phe Leu Lys Arg Asp Asn 
                325                 330                 335     


Leu Leu Ile Ala Asp Ile Glu Leu Gly Cys Gly Asn Phe Gly Ser Val 
            340                 345                 350         


Arg Gln Gly Val Tyr Arg Met Arg Lys Lys Gln Ile Asp Val Ala Ile 
        355                 360                 365             


Lys Val Leu Lys Gln Gly Thr Glu Lys Ala Asp Thr Glu Glu Met Met 
    370                 375                 380                 


Arg Glu Ala Gln Ile Met His Gln Leu Asp Asn Pro Tyr Ile Val Arg 
385                 390                 395                 400 


Leu Ile Gly Val Cys Gln Ala Glu Ala Leu Met Leu Val Met Glu Met 
                405                 410                 415     


Ala Gly Gly Gly Pro Leu His Lys Phe Leu Val Gly Lys Arg Glu Glu 
            420                 425                 430         


Ile Pro Val Ser Asn Val Ala Glu Leu Leu His Gln Val Ser Met Gly 
        435                 440                 445             


Met Lys Tyr Leu Glu Glu Lys Asn Phe Val His Arg Asp Leu Ala Ala 
    450                 455                 460                 


Arg Asn Val Leu Leu Val Asn Arg His Tyr Ala Lys Ile Ser Asp Phe 
465                 470                 475                 480 


Gly Leu Ser Lys Ala Leu Gly Ala Asp Asp Ser Tyr Tyr Thr Ala Arg 
                485                 490                 495     


Ser Ala Gly Lys Trp Pro Leu Lys Trp Tyr Ala Pro Glu Cys Ile Asn 
            500                 505                 510         


Phe Arg Lys Phe Ser Ser Arg Ser Asp Val Trp Ser Tyr Gly Val Thr 
        515                 520                 525             


Met Trp Glu Ala Leu Ser Tyr Gly Gln Lys Pro Tyr Lys Lys Met Lys 
    530                 535                 540                 


Gly Pro Glu Val Met Ala Phe Ile Glu Gln Gly Lys Arg Met Glu Cys 
545                 550                 555                 560 


Pro Pro Glu Cys Pro Pro Glu Leu Tyr Ala Leu Met Ser Asp Cys Trp 
                565                 570                 575     


Ile Tyr Lys Trp Glu Asp Arg Pro Asp Phe Leu Thr Val Glu Gln Arg 
            580                 585                 590         


Met Arg Ala Cys Tyr Tyr Ser Leu Ala Ser Lys Val Glu Gly Pro Pro 
        595                 600                 605             


Gly Ser Thr Gln Lys Ala Glu Ala Ala Cys Ala 
    610                 615                 


<210>  13
<211>  5449
<212>  DNA
<213>  Homo sapiens

<400>  13
cacacaggaa ggagccgagt gggactttcc tctcgctgcc tcccggctct gcccgccctt       60

cgaaagtcca gggtccctgc ccgctaggca agttgcactc atggcacctc caagtgaaga      120

gacgcccctg atccctcagc gttcatgcag cctcttgtcc acggaggctg gtgccctgca      180

tgtgctgctg cccgctcggg gccccgggcc cccccagcgc ctatctttct cctttgggga      240

ccacttggct gaggacctgt gcgtgcaggc tgccaaggcc agcggcatcc tgcctgtgta      300

ccactccctc tttgctctgg ccacggagga cctgtcctgc tggttccccc cgagccacat      360

cttctccgtg gaggatgcca gcacccaagt cctgctgtac aggattcgct tttacttccc      420

caattggttt gggctggaga agtgccaccg cttcgggcta cgcaaggatt tggccagtgc      480

tatccttgac ctgccagtcc tggagcacct ctttgcccag caccgcagtg acctggtgag      540

tgggcgcctc cccgtgggcc tcagtctcaa ggagcagggt gagtgtctca gcctggccgt      600

gttggacctg gcccggatgg cgcgagagca ggcccagcgg ccgggagagc tgctgaagac      660

tgtcagctac aaggcctgcc tacccccaag cctgcgcgac ctgatccagg gcctgagctt      720

cgtgacgcgg aggcgtattc ggaggacggt gcgcagagcc ctgcgccgcg tggccgcctg      780

ccaggcagac cggcactcgc tcatggccaa gtacatcatg gacctggagc ggctggatcc      840

agccggggcc gccgagacct tccacgtggg cctccctggg gcccttggtg gccacgacgg      900

gctggggctg ctccgcgtgg ctggtgacgg cggcatcgcc tggacccagg gagaacagga      960

ggtcctccag cccttctgcg actttccaga aatcgtagac attagcatca agcaggcccc     1020

gcgcgttggc ccggccggag agcaccgcct ggtcactgtt accaggacag acaaccagat     1080

tttagaggcc gagttcccag ggctgcccga ggctctgtcg ttcgtggcgc tcgtggacgg     1140

ctacttccgg ctgaccacgg actcccagca cttcttctgc aaggaggtgg caccgccgag     1200

gctgctggag gaagtggccg agcagtgcca cggccccatc actctggact ttgccatcaa     1260

caagctcaag actgggggct cacgtcctgg ctcctatgtt ctccgccgca gcccccagga     1320

ctttgacagc ttcctcctca ctgtctgtgt ccagaacccc cttggtcctg attataaggg     1380

ctgcctcatc cggcgcagcc ccacaggaac cttccttctg gttggcctca gccgacccca     1440

cagcagtctt cgagagctcc tggcaacctg ctgggatggg gggctgcacg tagatggggt     1500

ggcagtgacc ctcacttcct gctgtatccc cagacccaaa gaaaagtcca acctgatcgt     1560

ggtccagaga ggtcacagcc cacccacatc atccttggtt cagccccaat cccaatacca     1620

gctgagtcag atgacatttc acaagatccc tgctgacagc ctggagtggc atgagaacct     1680

gggccatggg tccttcacca agatttaccg gggctgtcgc catgaggtgg tggatgggga     1740

ggcccgaaag acagaggtgc tgctgaaggt catggatgcc aagcacaaga actgcatgga     1800

gtcattcctg gaagcagcga gcttgatgag ccaagtgtcg taccggcatc tcgtgctgct     1860

ccacggcgtg tgcatggctg gagacagcac catggtgcag gaatttgtac acctgggggc     1920

catagacatg tatctgcgaa aacgtggcca cctggtgcca gccagctgga agctgcaggt     1980

ggtcaaacag ctggcctacg ccctcaacta tctggaggac aaaggcctgc cccatggcaa     2040

tgtctctgcc cggaaggtgc tcctggctcg ggagggggct gatgggagcc cgcccttcat     2100

caagctgagt gaccctgggg tcagccccgc tgtgttaagc ctggagatgc tcaccgacag     2160

gatcccctgg gtggcccccg agtgtctccg ggaggcgcag acacttagct tggaagctga     2220

caagtggggc ttcggcgcca cggtctggga agtgtttagt ggcgtcacca tgcccatcag     2280

tgccctggat cctgctaaga aactccaatt ttatgaggac cggcagcagc tgccggcccc     2340

caagtggaca gagctggccc tgctgattca acagtgcatg gcctatgagc cggtccagag     2400

gccctccttc cgagccgtca ttcgtgacct caatagcctc atctcttcag actatgagct     2460

cctctcagac cccacacctg gtgccctggc acctcgtgat gggctgtgga atggtgccca     2520

gctctatgcc tgccaagacc ccacgatctt cgaggagaga cacctcaagt acatctcaca     2580

gctgggcaag ggcaactttg gcagcgtgga gctgtgccgc tatgacccgc taggcgacaa     2640

tacaggtgcc ctggtggccg tgaaacagct gcagcacagc gggccagacc agcagaggga     2700

ctttcagcgg gagattcaga tcctcaaagc actgcacagt gatttcattg tcaagtatcg     2760

tggtgtcagc tatggcccgg gccgccagag cctgcggctg gtcatggagt acctgcccag     2820

cggctgcttg cgcgacttcc tgcagcggca ccgcgcgcgc ctcgatgcca gccgcctcct     2880

tctctattcc tcgcagatct gcaagggcat ggagtacctg ggctcccgcc gctgcgtgca     2940

ccgcgacctg gccgcccgaa acatcctcgt ggagagcgag gcacacgtca agatcgctga     3000

cttcggccta gctaagctgc tgccgcttga caaagactac tacgtggtcc gcgagccagg     3060

ccagagcccc attttctggt atgcccccga atccctctcg gacaacatct tctctcgcca     3120

gtcagacgtc tggagcttcg gggtcgtcct gtacgagctc ttcacctact gcgacaaaag     3180

ctgcagcccc tcggccgagt tcctgcggat gatgggatgt gagcgggatg tccccgccct     3240

ctgccgcctc ttggaactgc tggaggaggg ccagaggctg ccggcgcctc ctgcctgccc     3300

tgctgaggtt cacgagctca tgaagctgtg ctgggcccct agcccacagg accggccatc     3360

attcagcgcc ctgggccccc agctggacat gctgtggagc ggaagccggg ggtgtgagac     3420

tcatgccttc actgctcacc cagagggcaa acaccactcc ctgtcctttt catagctcct     3480

gcccgcagac ctctggatta ggtctctgtt gactggctgt gtgaccttag gcccggagct     3540

gcccctctct gggcctcaga ggccttatga gggtcctcta cttcaggaac acccccatga     3600

cattgcattt gggggggctc ccgtggcctg tagaatagcc tgtggccttt gcaatttgtt     3660

aaggttcaag acagatgggc atatgtgtca gtggggctct ctgagtcctg gcccaaagaa     3720

gcaaggaacc aaatttaaga ctctcgcatc ttcccaaccc cttaagccct ggccccctga     3780

gtttcctttt ctgtctctct ctttttattt tttttatttt tatttttatt tttgagacag     3840

agcctcgctc tgttacccag ggtggagtgc agtggtgcga tctcggctca gtgcaacctc     3900

tgcttcccag gttcaagcga ttctcctgcc tcagcctccc gagtagctgg gattacaggt     3960

gtgcaccacc acacccggct aatttttttt atttttaata gagatgaggt ttcaccatga     4020

tggccaggct gatctcgaac tcctaacctc aagtgatcct cccacctcag cctcccaaag     4080

tgttggaata ataggcatga gccactgcac ccaggctttt ttttttttaa atttattatt     4140

attattttta agagacagga tcttgctacg ttgcccaggc tggtcttgaa ctcctgggct     4200

acagtgatcc tcctgcctta tcctcctaaa tagctgggac tacagcacct agttttgagt     4260

ttcctgtctt atttccaatg gggacattca tgtagctttt tttttttttt tttttttgag     4320

acggagtctc gctctgtcgc ccaggctgga gtacagtggc gcaatctagg ctcactgcaa     4380

gctccgcctc ctgggttcac accattctct cgcctcagcc tcccaagtag ctgggactac     4440

aggcgcccgc caccacaccc ggctaatttt ttgtattttt agtagagacg gggtttcacc     4500

ttgttagcca ggatggtttc catctcctga cctcgtgatc tgcccgtctc ggcctcccaa     4560

agtgctggga ttacaggcat gagccactgc gcccggccct catgtagctt taaatgtatg     4620

atctgacttc tgctccccga tctctgtttc tctggaggaa gccaaggaca agagcagttg     4680

ctgtggctgg gactctgcct tttaggggag cccgtgtatc tctttgggat cctgaaaggg     4740

ggcaggaaag gctggggtcc cagtccaccc taatggtatc tgagtgtcct agggcttcag     4800

ttttcccacc tgtccaatgg gaccctttct gtcctcaccc tacaaggggc acaaagggat     4860

gacaccaaac ctggcaggaa cttttcacgc aatcaaggga aggaaaggca ttcctggcag     4920

agggaacagc atgccaagcg tgagaaggct cagagtaagg aggttaagag cccaagtatt     4980

ggagcctaca gttttgcccc ttccatgcag tgtgacagtg ggcaagttcc tttccctctc     5040

tgggtctcag ttctgtcccc tgcaaaatgg tcagagctta ccccttggct gtgcagggtc     5100

aactttctga ctggtgagag ggattctcat gcaggttaag cttctgctgc tcctcctcac     5160

ctgcaaagct tttctgccac ttttgcctcc ttggaaaact cttatccatc tctcaaaact     5220

ccagctacca catccttgca gccttccctc atataccccc actactactg tagccctgtc     5280

cttccctcca gccccactct ggccctgggg ctggggaagt gtctgtgtcc agctgtctcc     5340

cctgacctca gggttccttg ggggctgggc tgaggcctca gtacagaggg ggctctggaa     5400

atgtttgttg actgaataaa ggaattcagt ggaaaaaaaa aaaaaaaaa                 5449


<210>  14
<211>  1124
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Ala Pro Pro Ser Glu Glu Thr Pro Leu Ile Pro Gln Arg Ser Cys 
1               5                   10                  15      


Ser Leu Leu Ser Thr Glu Ala Gly Ala Leu His Val Leu Leu Pro Ala 
            20                  25                  30          


Arg Gly Pro Gly Pro Pro Gln Arg Leu Ser Phe Ser Phe Gly Asp His 
        35                  40                  45              


Leu Ala Glu Asp Leu Cys Val Gln Ala Ala Lys Ala Ser Gly Ile Leu 
    50                  55                  60                  


Pro Val Tyr His Ser Leu Phe Ala Leu Ala Thr Glu Asp Leu Ser Cys 
65                  70                  75                  80  


Trp Phe Pro Pro Ser His Ile Phe Ser Val Glu Asp Ala Ser Thr Gln 
                85                  90                  95      


Val Leu Leu Tyr Arg Ile Arg Phe Tyr Phe Pro Asn Trp Phe Gly Leu 
            100                 105                 110         


Glu Lys Cys His Arg Phe Gly Leu Arg Lys Asp Leu Ala Ser Ala Ile 
        115                 120                 125             


Leu Asp Leu Pro Val Leu Glu His Leu Phe Ala Gln His Arg Ser Asp 
    130                 135                 140                 


Leu Val Ser Gly Arg Leu Pro Val Gly Leu Ser Leu Lys Glu Gln Gly 
145                 150                 155                 160 


Glu Cys Leu Ser Leu Ala Val Leu Asp Leu Ala Arg Met Ala Arg Glu 
                165                 170                 175     


Gln Ala Gln Arg Pro Gly Glu Leu Leu Lys Thr Val Ser Tyr Lys Ala 
            180                 185                 190         


Cys Leu Pro Pro Ser Leu Arg Asp Leu Ile Gln Gly Leu Ser Phe Val 
        195                 200                 205             


Thr Arg Arg Arg Ile Arg Arg Thr Val Arg Arg Ala Leu Arg Arg Val 
    210                 215                 220                 


Ala Ala Cys Gln Ala Asp Arg His Ser Leu Met Ala Lys Tyr Ile Met 
225                 230                 235                 240 


Asp Leu Glu Arg Leu Asp Pro Ala Gly Ala Ala Glu Thr Phe His Val 
                245                 250                 255     


Gly Leu Pro Gly Ala Leu Gly Gly His Asp Gly Leu Gly Leu Leu Arg 
            260                 265                 270         


Val Ala Gly Asp Gly Gly Ile Ala Trp Thr Gln Gly Glu Gln Glu Val 
        275                 280                 285             


Leu Gln Pro Phe Cys Asp Phe Pro Glu Ile Val Asp Ile Ser Ile Lys 
    290                 295                 300                 


Gln Ala Pro Arg Val Gly Pro Ala Gly Glu His Arg Leu Val Thr Val 
305                 310                 315                 320 


Thr Arg Thr Asp Asn Gln Ile Leu Glu Ala Glu Phe Pro Gly Leu Pro 
                325                 330                 335     


Glu Ala Leu Ser Phe Val Ala Leu Val Asp Gly Tyr Phe Arg Leu Thr 
            340                 345                 350         


Thr Asp Ser Gln His Phe Phe Cys Lys Glu Val Ala Pro Pro Arg Leu 
        355                 360                 365             


Leu Glu Glu Val Ala Glu Gln Cys His Gly Pro Ile Thr Leu Asp Phe 
    370                 375                 380                 


Ala Ile Asn Lys Leu Lys Thr Gly Gly Ser Arg Pro Gly Ser Tyr Val 
385                 390                 395                 400 


Leu Arg Arg Ser Pro Gln Asp Phe Asp Ser Phe Leu Leu Thr Val Cys 
                405                 410                 415     


Val Gln Asn Pro Leu Gly Pro Asp Tyr Lys Gly Cys Leu Ile Arg Arg 
            420                 425                 430         


Ser Pro Thr Gly Thr Phe Leu Leu Val Gly Leu Ser Arg Pro His Ser 
        435                 440                 445             


Ser Leu Arg Glu Leu Leu Ala Thr Cys Trp Asp Gly Gly Leu His Val 
    450                 455                 460                 


Asp Gly Val Ala Val Thr Leu Thr Ser Cys Cys Ile Pro Arg Pro Lys 
465                 470                 475                 480 


Glu Lys Ser Asn Leu Ile Val Val Gln Arg Gly His Ser Pro Pro Thr 
                485                 490                 495     


Ser Ser Leu Val Gln Pro Gln Ser Gln Tyr Gln Leu Ser Gln Met Thr 
            500                 505                 510         


Phe His Lys Ile Pro Ala Asp Ser Leu Glu Trp His Glu Asn Leu Gly 
        515                 520                 525             


His Gly Ser Phe Thr Lys Ile Tyr Arg Gly Cys Arg His Glu Val Val 
    530                 535                 540                 


Asp Gly Glu Ala Arg Lys Thr Glu Val Leu Leu Lys Val Met Asp Ala 
545                 550                 555                 560 


Lys His Lys Asn Cys Met Glu Ser Phe Leu Glu Ala Ala Ser Leu Met 
                565                 570                 575     


Ser Gln Val Ser Tyr Arg His Leu Val Leu Leu His Gly Val Cys Met 
            580                 585                 590         


Ala Gly Asp Ser Thr Met Val Gln Glu Phe Val His Leu Gly Ala Ile 
        595                 600                 605             


Asp Met Tyr Leu Arg Lys Arg Gly His Leu Val Pro Ala Ser Trp Lys 
    610                 615                 620                 


Leu Gln Val Val Lys Gln Leu Ala Tyr Ala Leu Asn Tyr Leu Glu Asp 
625                 630                 635                 640 


Lys Gly Leu Pro His Gly Asn Val Ser Ala Arg Lys Val Leu Leu Ala 
                645                 650                 655     


Arg Glu Gly Ala Asp Gly Ser Pro Pro Phe Ile Lys Leu Ser Asp Pro 
            660                 665                 670         


Gly Val Ser Pro Ala Val Leu Ser Leu Glu Met Leu Thr Asp Arg Ile 
        675                 680                 685             


Pro Trp Val Ala Pro Glu Cys Leu Arg Glu Ala Gln Thr Leu Ser Leu 
    690                 695                 700                 


Glu Ala Asp Lys Trp Gly Phe Gly Ala Thr Val Trp Glu Val Phe Ser 
705                 710                 715                 720 


Gly Val Thr Met Pro Ile Ser Ala Leu Asp Pro Ala Lys Lys Leu Gln 
                725                 730                 735     


Phe Tyr Glu Asp Arg Gln Gln Leu Pro Ala Pro Lys Trp Thr Glu Leu 
            740                 745                 750         


Ala Leu Leu Ile Gln Gln Cys Met Ala Tyr Glu Pro Val Gln Arg Pro 
        755                 760                 765             


Ser Phe Arg Ala Val Ile Arg Asp Leu Asn Ser Leu Ile Ser Ser Asp 
    770                 775                 780                 


Tyr Glu Leu Leu Ser Asp Pro Thr Pro Gly Ala Leu Ala Pro Arg Asp 
785                 790                 795                 800 


Gly Leu Trp Asn Gly Ala Gln Leu Tyr Ala Cys Gln Asp Pro Thr Ile 
                805                 810                 815     


Phe Glu Glu Arg His Leu Lys Tyr Ile Ser Gln Leu Gly Lys Gly Asn 
            820                 825                 830         


Phe Gly Ser Val Glu Leu Cys Arg Tyr Asp Pro Leu Gly Asp Asn Thr 
        835                 840                 845             


Gly Ala Leu Val Ala Val Lys Gln Leu Gln His Ser Gly Pro Asp Gln 
    850                 855                 860                 


Gln Arg Asp Phe Gln Arg Glu Ile Gln Ile Leu Lys Ala Leu His Ser 
865                 870                 875                 880 


Asp Phe Ile Val Lys Tyr Arg Gly Val Ser Tyr Gly Pro Gly Arg Gln 
                885                 890                 895     


Ser Leu Arg Leu Val Met Glu Tyr Leu Pro Ser Gly Cys Leu Arg Asp 
            900                 905                 910         


Phe Leu Gln Arg His Arg Ala Arg Leu Asp Ala Ser Arg Leu Leu Leu 
        915                 920                 925             


Tyr Ser Ser Gln Ile Cys Lys Gly Met Glu Tyr Leu Gly Ser Arg Arg 
    930                 935                 940                 


Cys Val His Arg Asp Leu Ala Ala Arg Asn Ile Leu Val Glu Ser Glu 
945                 950                 955                 960 


Ala His Val Lys Ile Ala Asp Phe Gly Leu Ala Lys Leu Leu Pro Leu 
                965                 970                 975     


Asp Lys Asp Tyr Tyr Val Val Arg Glu Pro Gly Gln Ser Pro Ile Phe 
            980                 985                 990         


Trp Tyr Ala Pro Glu Ser Leu Ser  Asp Asn Ile Phe Ser  Arg Gln Ser 
        995                 1000                 1005             


Asp Val  Trp Ser Phe Gly Val  Val Leu Tyr Glu Leu  Phe Thr Tyr 
    1010                 1015                 1020             


Cys Asp  Lys Ser Cys Ser Pro  Ser Ala Glu Phe Leu  Arg Met Met 
    1025                 1030                 1035             


Gly Cys  Glu Arg Asp Val Pro  Ala Leu Cys Arg Leu  Leu Glu Leu 
    1040                 1045                 1050             


Leu Glu  Glu Gly Gln Arg Leu  Pro Ala Pro Pro Ala  Cys Pro Ala 
    1055                 1060                 1065             


Glu Val  His Glu Leu Met Lys  Leu Cys Trp Ala Pro  Ser Pro Gln 
    1070                 1075                 1080             


Asp Arg  Pro Ser Phe Ser Ala  Leu Gly Pro Gln Leu  Asp Met Leu 
    1085                 1090                 1095             


Trp Ser  Gly Ser Arg Gly Cys  Glu Thr His Ala Phe  Thr Ala His 
    1100                 1105                 1110             


Pro Glu  Gly Lys His His Ser  Leu Ser Phe Ser 
    1115                 1120                 


<210>  15
<211>  2611
<212>  DNA
<213>  Homo sapiens

<400>  15
aactgagtgg ctgtgaaagg gtggggtttg ctcagactgt ccttcctctc tggactgtaa       60

gaatatgtct ccagggccag tgtctgctgc gatcgagtcc caccttccaa gtcctggcat      120

ctcaatgcat ctgggaagct acctgcatta agtcaggact gagcacacag gtgaactcca      180

gaaagaagaa gctatggccg cagtgattct ggagagcatc tttctgaagc gatcccaaca      240

gaaaaagaaa acatcacctc taaacttcaa gaagcgcctg tttctcttga ccgtgcacaa      300

actctcctac tatgagtatg actttgaacg tgggagaaga ggcagtaaga agggttcaat      360

agatgttgag aagatcactt gtgttgaaac agtggttcct gaaaaaaatc ctcctccaga      420

aagacagatt ccgagaagag gtgaagagtc cagtgaaatg gagcaaattt caatcattga      480

aaggttccct tatcccttcc aggttgtata tgatgaaggg cctctctacg tcttctcccc      540

aactgaagaa ctaaggaagc ggtggattca ccagctcaaa aacgtaatcc ggtacaacag      600

tgatctggtt cagaaatatc acccttgctt ctggatcgat gggcagtatc tctgctgctc      660

tcagacagcc aaaaatgcta tgggctgcca aattttggag aacaggaatg gaagcttaaa      720

acctgggagt tctcaccgga agacaaaaaa gcctcttccc ccaacgcctg aggaggacca      780

gatcttgaaa aagccactac cgcctgagcc agcagcagca ccagtctcca caagtgagct      840

gaaaaaggtt gtggcccttt atgattacat gccaatgaat gcaaatgatc tacagctgcg      900

gaagggtgat gaatatttta tcttggagga aagcaactta ccatggtgga gagcacgaga      960

taaaaatggg caggaaggct acattcctag taactatgtc actgaagcag aagactccat     1020

agaaatgtat gagtggtatt ccaaacacat gactcggagt caggctgagc aactgctaaa     1080

gcaagagggg aaagaaggag gtttcattgt cagagactcc agcaaagctg gcaaatatac     1140

agtgtctgtg tttgctaaat ccacagggga ccctcaaggg gtgatacgtc attatgttgt     1200

gtgttccaca cctcagagcc agtattacct ggctgagaag caccttttca gcaccatccc     1260

tgagctcatt aactaccatc agcacaactc tgcaggactc atatccaggc tcaaatatcc     1320

agtgtctcaa caaaacaaga atgcaccttc cactgcaggc ctgggatacg gatcatggga     1380

aattgatcca aaggacctga ccttcttgaa ggagctgggg actggacaat ttggggtagt     1440

gaagtatggg aaatggagag gccagtacga cgtggccatc aagatgatca aagaaggctc     1500

catgtctgaa gatgaattca ttgaagaagc caaagtcatg atgaatcttt cccatgagaa     1560

gctggtgcag ttgtatggcg tctgcaccaa gcagcgcccc atcttcatca tcactgagta     1620

catggccaat ggctgcctcc tgaactacct gagggagatg cgccaccgct tccagactca     1680

gcagctgcta gagatgtgca aggatgtctg tgaagccatg gaatacctgg agtcaaagca     1740

gttccttcac cgagacctgg cagctcgaaa ctgtttggta aacgatcaag gagttgttaa     1800

agtatctgat ttcggcctgt ccaggtatgt cctggatgat gaatacacaa gctcagtagg     1860

ctccaaattt ccagtccggt ggtccccacc ggaagtcctg atgtatagca agttcagcag     1920

caaatctgac atttgggctt ttggggtttt gatgtgggaa atttactccc tggggaagat     1980

gccatatgag agatttacta acagtgagac tgctgaacac attgcccaag gcctacgtct     2040

ctacaggcct catctggctt cagagaaggt atataccatc atgtacagtt gctggcatga     2100

gaaagcagat gagcgtccca ctttcaaaat tcttctgagc aatattctag atgtcatgga     2160

tgaagaatcc tgagctcgcc aataagcttc ttggttctac ttctcttctc cacaagcccc     2220

aatttcactt tctcagagga aatcccaagc ttaggagccc tggagccttt gtgctcccac     2280

tcaatacaaa aaggcccctc tctacatctg ggaatgcacc tcttctttga ttccctggga     2340

tagtggcttc tgagcaaagg ccaagaaatt attgtgcctg aaatttcccg agagaattaa     2400

gacagactga atttgcgatg aaaatatttt ttaggaggga ggatgtaaat agccgcacaa     2460

aggggtccaa cagctctttg agtaggcatt tggtagagct tgggggtgtg tgtgtggggg     2520

tggaccgaat ttggcaagaa tgaaatggtg tcataaagat gggaggggag ggtgttttga     2580

taaaataaaa ttactagaaa gcttgaaagt c                                    2611


<210>  16
<211>  659
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Ala Ala Val Ile Leu Glu Ser Ile Phe Leu Lys Arg Ser Gln Gln 
1               5                   10                  15      


Lys Lys Lys Thr Ser Pro Leu Asn Phe Lys Lys Arg Leu Phe Leu Leu 
            20                  25                  30          


Thr Val His Lys Leu Ser Tyr Tyr Glu Tyr Asp Phe Glu Arg Gly Arg 
        35                  40                  45              


Arg Gly Ser Lys Lys Gly Ser Ile Asp Val Glu Lys Ile Thr Cys Val 
    50                  55                  60                  


Glu Thr Val Val Pro Glu Lys Asn Pro Pro Pro Glu Arg Gln Ile Pro 
65                  70                  75                  80  


Arg Arg Gly Glu Glu Ser Ser Glu Met Glu Gln Ile Ser Ile Ile Glu 
                85                  90                  95      


Arg Phe Pro Tyr Pro Phe Gln Val Val Tyr Asp Glu Gly Pro Leu Tyr 
            100                 105                 110         


Val Phe Ser Pro Thr Glu Glu Leu Arg Lys Arg Trp Ile His Gln Leu 
        115                 120                 125             


Lys Asn Val Ile Arg Tyr Asn Ser Asp Leu Val Gln Lys Tyr His Pro 
    130                 135                 140                 


Cys Phe Trp Ile Asp Gly Gln Tyr Leu Cys Cys Ser Gln Thr Ala Lys 
145                 150                 155                 160 


Asn Ala Met Gly Cys Gln Ile Leu Glu Asn Arg Asn Gly Ser Leu Lys 
                165                 170                 175     


Pro Gly Ser Ser His Arg Lys Thr Lys Lys Pro Leu Pro Pro Thr Pro 
            180                 185                 190         


Glu Glu Asp Gln Ile Leu Lys Lys Pro Leu Pro Pro Glu Pro Ala Ala 
        195                 200                 205             


Ala Pro Val Ser Thr Ser Glu Leu Lys Lys Val Val Ala Leu Tyr Asp 
    210                 215                 220                 


Tyr Met Pro Met Asn Ala Asn Asp Leu Gln Leu Arg Lys Gly Asp Glu 
225                 230                 235                 240 


Tyr Phe Ile Leu Glu Glu Ser Asn Leu Pro Trp Trp Arg Ala Arg Asp 
                245                 250                 255     


Lys Asn Gly Gln Glu Gly Tyr Ile Pro Ser Asn Tyr Val Thr Glu Ala 
            260                 265                 270         


Glu Asp Ser Ile Glu Met Tyr Glu Trp Tyr Ser Lys His Met Thr Arg 
        275                 280                 285             


Ser Gln Ala Glu Gln Leu Leu Lys Gln Glu Gly Lys Glu Gly Gly Phe 
    290                 295                 300                 


Ile Val Arg Asp Ser Ser Lys Ala Gly Lys Tyr Thr Val Ser Val Phe 
305                 310                 315                 320 


Ala Lys Ser Thr Gly Asp Pro Gln Gly Val Ile Arg His Tyr Val Val 
                325                 330                 335     


Cys Ser Thr Pro Gln Ser Gln Tyr Tyr Leu Ala Glu Lys His Leu Phe 
            340                 345                 350         


Ser Thr Ile Pro Glu Leu Ile Asn Tyr His Gln His Asn Ser Ala Gly 
        355                 360                 365             


Leu Ile Ser Arg Leu Lys Tyr Pro Val Ser Gln Gln Asn Lys Asn Ala 
    370                 375                 380                 


Pro Ser Thr Ala Gly Leu Gly Tyr Gly Ser Trp Glu Ile Asp Pro Lys 
385                 390                 395                 400 


Asp Leu Thr Phe Leu Lys Glu Leu Gly Thr Gly Gln Phe Gly Val Val 
                405                 410                 415     


Lys Tyr Gly Lys Trp Arg Gly Gln Tyr Asp Val Ala Ile Lys Met Ile 
            420                 425                 430         


Lys Glu Gly Ser Met Ser Glu Asp Glu Phe Ile Glu Glu Ala Lys Val 
        435                 440                 445             


Met Met Asn Leu Ser His Glu Lys Leu Val Gln Leu Tyr Gly Val Cys 
    450                 455                 460                 


Thr Lys Gln Arg Pro Ile Phe Ile Ile Thr Glu Tyr Met Ala Asn Gly 
465                 470                 475                 480 


Cys Leu Leu Asn Tyr Leu Arg Glu Met Arg His Arg Phe Gln Thr Gln 
                485                 490                 495     


Gln Leu Leu Glu Met Cys Lys Asp Val Cys Glu Ala Met Glu Tyr Leu 
            500                 505                 510         


Glu Ser Lys Gln Phe Leu His Arg Asp Leu Ala Ala Arg Asn Cys Leu 
        515                 520                 525             


Val Asn Asp Gln Gly Val Val Lys Val Ser Asp Phe Gly Leu Ser Arg 
    530                 535                 540                 


Tyr Val Leu Asp Asp Glu Tyr Thr Ser Ser Val Gly Ser Lys Phe Pro 
545                 550                 555                 560 


Val Arg Trp Ser Pro Pro Glu Val Leu Met Tyr Ser Lys Phe Ser Ser 
                565                 570                 575     


Lys Ser Asp Ile Trp Ala Phe Gly Val Leu Met Trp Glu Ile Tyr Ser 
            580                 585                 590         


Leu Gly Lys Met Pro Tyr Glu Arg Phe Thr Asn Ser Glu Thr Ala Glu 
        595                 600                 605             


His Ile Ala Gln Gly Leu Arg Leu Tyr Arg Pro His Leu Ala Ser Glu 
    610                 615                 620                 


Lys Val Tyr Thr Ile Met Tyr Ser Cys Trp His Glu Lys Ala Asp Glu 
625                 630                 635                 640 


Arg Pro Thr Phe Lys Ile Leu Leu Ser Asn Ile Leu Asp Val Met Asp 
                645                 650                 655     


Glu Glu Ser 
            


<210>  17
<211>  1844
<212>  DNA
<213>  Homo sapiens

<400>  17
tcctcttctt accctgcacc cagagcctcg ccagagaaga caagggcaga aagcaccatg       60

agtgggggcc caatgggagg aaggcccggg ggccgaggag caccagcggt tcagcagaac      120

ataccctcca ccctcctcca ggaccacgag aaccagcgac tctttgagat gcttggacga      180

aaatgcttga cgctggccac tgcagttgtt cagctgtacc tggcgctgcc ccctggagct      240

gagcactgga ccaaggagca ttgtggggct gtgtgcttcg tgaaggataa cccccagaag      300

tcctacttca tccgccttta cggccttcag gctggtcggc tgctctggga acaggagctg      360

tactcacagc ttgtctactc cacccccacc cccttcttcc acaccttcgc tggagatgac      420

tgccaagcgg ggctgaactt tgcagacgag gacgaggccc aggccttccg ggccctcgtg      480

caggagaaga tacaaaaaag gaatcagagg caaagtggag acagacgcca gctaccccca      540

ccaccaacac cagccaatga agagagaaga ggagggctcc cacccctgcc cctgcatcca      600

ggtggagacc aaggaggccc tccagtgggt ccgctctccc tggggctggc gacagtggac      660

atccagaacc ctgacatcac gagttcacga taccgtgggc tcccagcacc tggacctagc      720

ccagctgata agaaacgctc agggaagaag aagatcagca aagctgatat tggtgcaccc      780

agtggattca agcatgtcag ccacgtgggg tgggaccccc agaatggatt tgacgtgaac      840

aacctcgacc cagatctgcg gagtctgttc tccagggcag gaatcagcga ggcccagctc      900

accgacgccg agacctctaa acttatctac gacttcattg aggaccaggg tgggctggag      960

gctgtgcggc aggagatgag gcgccaggag ccacttccgc cgcccccacc gccatctcga     1020

ggagggaacc agctcccccg gccccctatt gtggggggta acaagggtcg ttctggtcca     1080

ctgccccctg tacctttggg gattgcccca cccccaccaa caccccgggg acccccaccc     1140

ccaggccgag ggggccctcc accaccaccc cctccagcta ctggacgttc tggaccactg     1200

ccccctccac cccctggagc tggtgggcca cccatgccac caccaccgcc accaccgcca     1260

ccgccgccca gctccgggaa tggaccagcc cctcccccac tccctcctgc tctggtgcct     1320

gccgggggcc tggcccctgg tgggggtcgg ggagcgcttt tggatcaaat ccggcaggga     1380

attcagctga acaagacccc tggggcccca gagagctcag cgctgcagcc accacctcag     1440

agctcagagg gactggtggg ggccctgatg cacgtgatgc agaagagaag cagagccatc     1500

cactcctccg acgaagggga ggaccaggct ggcgatgaag atgaagatga tgaatgggat     1560

gactgagtgg ctgagttact tgctgccctg tgctcctccc cgcaggacat ggctccccct     1620

ccacctgctc tgtgcccacc ctccactctc ctcttccagg cccccaaccc cccatttctt     1680

ccccaccaac ccctccaatg ctgttatccc tgcctggtcc tcacactcac ccaacaatcc     1740

caaggccctt tttatacaaa aattctcagt tctcttcact caaggatttt taaagaaaaa     1800

taaaagaatt gtctttctgt ctctctataa aaaaaaaaaa aaaa                      1844


<210>  18
<211>  502
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Ser Gly Gly Pro Met Gly Gly Arg Pro Gly Gly Arg Gly Ala Pro 
1               5                   10                  15      


Ala Val Gln Gln Asn Ile Pro Ser Thr Leu Leu Gln Asp His Glu Asn 
            20                  25                  30          


Gln Arg Leu Phe Glu Met Leu Gly Arg Lys Cys Leu Thr Leu Ala Thr 
        35                  40                  45              


Ala Val Val Gln Leu Tyr Leu Ala Leu Pro Pro Gly Ala Glu His Trp 
    50                  55                  60                  


Thr Lys Glu His Cys Gly Ala Val Cys Phe Val Lys Asp Asn Pro Gln 
65                  70                  75                  80  


Lys Ser Tyr Phe Ile Arg Leu Tyr Gly Leu Gln Ala Gly Arg Leu Leu 
                85                  90                  95      


Trp Glu Gln Glu Leu Tyr Ser Gln Leu Val Tyr Ser Thr Pro Thr Pro 
            100                 105                 110         


Phe Phe His Thr Phe Ala Gly Asp Asp Cys Gln Ala Gly Leu Asn Phe 
        115                 120                 125             


Ala Asp Glu Asp Glu Ala Gln Ala Phe Arg Ala Leu Val Gln Glu Lys 
    130                 135                 140                 


Ile Gln Lys Arg Asn Gln Arg Gln Ser Gly Asp Arg Arg Gln Leu Pro 
145                 150                 155                 160 


Pro Pro Pro Thr Pro Ala Asn Glu Glu Arg Arg Gly Gly Leu Pro Pro 
                165                 170                 175     


Leu Pro Leu His Pro Gly Gly Asp Gln Gly Gly Pro Pro Val Gly Pro 
            180                 185                 190         


Leu Ser Leu Gly Leu Ala Thr Val Asp Ile Gln Asn Pro Asp Ile Thr 
        195                 200                 205             


Ser Ser Arg Tyr Arg Gly Leu Pro Ala Pro Gly Pro Ser Pro Ala Asp 
    210                 215                 220                 


Lys Lys Arg Ser Gly Lys Lys Lys Ile Ser Lys Ala Asp Ile Gly Ala 
225                 230                 235                 240 


Pro Ser Gly Phe Lys His Val Ser His Val Gly Trp Asp Pro Gln Asn 
                245                 250                 255     


Gly Phe Asp Val Asn Asn Leu Asp Pro Asp Leu Arg Ser Leu Phe Ser 
            260                 265                 270         


Arg Ala Gly Ile Ser Glu Ala Gln Leu Thr Asp Ala Glu Thr Ser Lys 
        275                 280                 285             


Leu Ile Tyr Asp Phe Ile Glu Asp Gln Gly Gly Leu Glu Ala Val Arg 
    290                 295                 300                 


Gln Glu Met Arg Arg Gln Glu Pro Leu Pro Pro Pro Pro Pro Pro Ser 
305                 310                 315                 320 


Arg Gly Gly Asn Gln Leu Pro Arg Pro Pro Ile Val Gly Gly Asn Lys 
                325                 330                 335     


Gly Arg Ser Gly Pro Leu Pro Pro Val Pro Leu Gly Ile Ala Pro Pro 
            340                 345                 350         


Pro Pro Thr Pro Arg Gly Pro Pro Pro Pro Gly Arg Gly Gly Pro Pro 
        355                 360                 365             


Pro Pro Pro Pro Pro Ala Thr Gly Arg Ser Gly Pro Leu Pro Pro Pro 
    370                 375                 380                 


Pro Pro Gly Ala Gly Gly Pro Pro Met Pro Pro Pro Pro Pro Pro Pro 
385                 390                 395                 400 


Pro Pro Pro Pro Ser Ser Gly Asn Gly Pro Ala Pro Pro Pro Leu Pro 
                405                 410                 415     


Pro Ala Leu Val Pro Ala Gly Gly Leu Ala Pro Gly Gly Gly Arg Gly 
            420                 425                 430         


Ala Leu Leu Asp Gln Ile Arg Gln Gly Ile Gln Leu Asn Lys Thr Pro 
        435                 440                 445             


Gly Ala Pro Glu Ser Ser Ala Leu Gln Pro Pro Pro Gln Ser Ser Glu 
    450                 455                 460                 


Gly Leu Val Gly Ala Leu Met His Val Met Gln Lys Arg Ser Arg Ala 
465                 470                 475                 480 


Ile His Ser Ser Asp Glu Gly Glu Asp Gln Ala Gly Asp Glu Asp Glu 
                485                 490                 495     


Asp Asp Glu Trp Asp Asp 
            500         


<210>  19
<211>  2869
<212>  DNA
<213>  Homo sapiens

<400>  19
ggtccaccca gtgcttgcgg cctcgcggcc gggccggcct gggctgcaat caatgcggct       60

ttgtctggga cgcccacatc ccagaggcca ttcccgggtc ggcaaatcgg agcgcggccg      120

gggcgcgcgg gggtgagata agcggccatg tgatcccacc tgggctggaa ggggaggggc      180

gccaggtgag gcggcggccg gcggggcgcg ggcggccacg cggggctcct gcagcatggc      240

tgtcagcagg aaggactggt ccgcgctgtc cagccttgcc cggcagagga ctctggagga      300

tgaggaggaa caggagcgcg agcgcaggcg gcggcaccgc aacctgagct ccaccacgga      360

cgatgaggct cccaggctca gccagaatgg agaccggcag gcctctgctt ctgagagact      420

accgagcgtg gaagaagcag aggtgcccaa gccactgccc ccagcctcca aagatgagga      480

cgaggacatc cagagcatcc tcagaacacg gcaggagcgg aggcagaggc ggcaggtggt      540

ggaggctgca caggccccca tccaggagag gctggaggca gaggagggga ggaacagctt      600

gagccctgtg caggccacac agaaacccct agtctccaag aaggaactgg aaatcccacc      660

tcgccggaga ctgagtcggg aacagcgggg cccctgggcc ctggaggagg agagcttggt      720

gggcagggag ccagaagaga ggaagaaagg ggttccagaa aagtccccag tcttggagaa      780

gtcctccatg ccaaagaaga cggcacctga aaagagcctg gtctccgata aaacctccat      840

ctctgagaag gtgctggcct cagagaagac atctctatca gagaagatag cagtgtcaga      900

gaaaagaaac agctcagaga agaagtctgt tctagaaaaa accagtgtct ctgagaagtc      960

gctggcccca gggatggcac tgggctcagg aaggaggctg gtgtctgaga aagcttccat     1020

ctttgagaag gcactggcct cagagaagag cccaactgca gatgctaagc cggccccaaa     1080

gagggccaca gcctcagagc agcccctggc gcaggagccg ccagcctctg ggggaagccc     1140

agccaccacc aaggagcaga gaggaagggc cctccctggg aagaacctgc cctctttggc     1200

aaagcagggg gcttcagacc ctccgactgt ggcctcccgc ctcccacccg tcacactcca     1260

ggtgaaaatc cccagcaagg aggaagaggc agatatgtcc tcacccacac agcgaaccta     1320

cagcagctcc ctcaaacgct ccagccccag gaccatctcc tttcggatga aacccaagaa     1380

agaaaactcg gaaacaaccc taactcgcag tgccagcatg aagctcccag acaacacagt     1440

gaagttggga gagaagctgg agagatacca cacggccata cggagatcag aatctgtcaa     1500

gtctcggggt ctgccttgca ctgagttatt cgtggctcct gtgggtgtag ccagcaagcg     1560

ccacctcttt gagaaggaac tggcgggcca gagccgagca gaaccagcct ccagccggaa     1620

ggagaacttg aggctctcag gggttgtgac atcaaggctc aacctgtgga tcagcaggac     1680

ccaggaatct ggagatcagg acccccagga ggcacagaaa gcatcatctg caaccgagag     1740

gactcagtgg ggacagaaat ctgactcctc gctggacgct gaggtgtgac aagccccgcc     1800

aagacagacc tgcaagtctt cgtctcaagg gacctccctc atgccaggcc cctgcctctc     1860

acagcagcac cctttcctct cattgtccct gttccctttt tgcctgtgga tctgtttggc     1920

cagggtccct ggggtcagga atatttgcaa gactcagcca gctccttccc agcccagcct     1980

cttggggctg ggactttctc accctgcggc aggcacaaca gatgctggga cccagtctct     2040

gcccaggtca cagcacaagt gcacatcagc actatggggc ctatgtcctg cccagagacc     2100

tctgctcctt cctgctcaca tccacagtca gggcacggcg cccctcaaga actccagagt     2160

cacctgtctc atcggctccc agcaagtgcc tctttgtcta tgatgtcccc cttctctgag     2220

gcctggaccc acccatcttt gtccctgggg cctgctccca gccactgagg cccgctctgg     2280

ccaggggaga aggagctgcc gtgcgtcttc cctgtgcccc gtctccctgc ttggttctcc     2340

cctcccttcc ctggccggct gccatggcca ggagctaagt gcctttttgt gtgcaaccac     2400

ttaccctttc tctgaaaaac ctgttctcag gaaggatctg ataaactcat ttactctcag     2460

gtgtaagaga ctgatgagac cttagaagcg aattcctctc tggaggcctt gctttctagc     2520

agaggtcacc tgaagtgtgt gaggaggatc atcattttcc tcatcccccc tcttctcaca     2580

ttaaggtggt ggcttgccac tcagcagtcc tagcttggtg actgggaact gccacataca     2640

gggccaggcc taccctcctt ccccacaagc cccctccaac ccccaccccc atgctctgga     2700

cctcatggct cctatgagct tggagcatgg tgaaccatca gagaatctag aaccaaccaa     2760

gctaggaaca tcagcctggt gccctgttaa ccccttaaag ctgtggttta caacttttca     2820

aaaatttaaa tcattagaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaa                 2869


<210>  20
<211>  517
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Ala Val Ser Arg Lys Asp Trp Ser Ala Leu Ser Ser Leu Ala Arg 
1               5                   10                  15      


Gln Arg Thr Leu Glu Asp Glu Glu Glu Gln Glu Arg Glu Arg Arg Arg 
            20                  25                  30          


Arg His Arg Asn Leu Ser Ser Thr Thr Asp Asp Glu Ala Pro Arg Leu 
        35                  40                  45              


Ser Gln Asn Gly Asp Arg Gln Ala Ser Ala Ser Glu Arg Leu Pro Ser 
    50                  55                  60                  


Val Glu Glu Ala Glu Val Pro Lys Pro Leu Pro Pro Ala Ser Lys Asp 
65                  70                  75                  80  


Glu Asp Glu Asp Ile Gln Ser Ile Leu Arg Thr Arg Gln Glu Arg Arg 
                85                  90                  95      


Gln Arg Arg Gln Val Val Glu Ala Ala Gln Ala Pro Ile Gln Glu Arg 
            100                 105                 110         


Leu Glu Ala Glu Glu Gly Arg Asn Ser Leu Ser Pro Val Gln Ala Thr 
        115                 120                 125             


Gln Lys Pro Leu Val Ser Lys Lys Glu Leu Glu Ile Pro Pro Arg Arg 
    130                 135                 140                 


Arg Leu Ser Arg Glu Gln Arg Gly Pro Trp Ala Leu Glu Glu Glu Ser 
145                 150                 155                 160 


Leu Val Gly Arg Glu Pro Glu Glu Arg Lys Lys Gly Val Pro Glu Lys 
                165                 170                 175     


Ser Pro Val Leu Glu Lys Ser Ser Met Pro Lys Lys Thr Ala Pro Glu 
            180                 185                 190         


Lys Ser Leu Val Ser Asp Lys Thr Ser Ile Ser Glu Lys Val Leu Ala 
        195                 200                 205             


Ser Glu Lys Thr Ser Leu Ser Glu Lys Ile Ala Val Ser Glu Lys Arg 
    210                 215                 220                 


Asn Ser Ser Glu Lys Lys Ser Val Leu Glu Lys Thr Ser Val Ser Glu 
225                 230                 235                 240 


Lys Ser Leu Ala Pro Gly Met Ala Leu Gly Ser Gly Arg Arg Leu Val 
                245                 250                 255     


Ser Glu Lys Ala Ser Ile Phe Glu Lys Ala Leu Ala Ser Glu Lys Ser 
            260                 265                 270         


Pro Thr Ala Asp Ala Lys Pro Ala Pro Lys Arg Ala Thr Ala Ser Glu 
        275                 280                 285             


Gln Pro Leu Ala Gln Glu Pro Pro Ala Ser Gly Gly Ser Pro Ala Thr 
    290                 295                 300                 


Thr Lys Glu Gln Arg Gly Arg Ala Leu Pro Gly Lys Asn Leu Pro Ser 
305                 310                 315                 320 


Leu Ala Lys Gln Gly Ala Ser Asp Pro Pro Thr Val Ala Ser Arg Leu 
                325                 330                 335     


Pro Pro Val Thr Leu Gln Val Lys Ile Pro Ser Lys Glu Glu Glu Ala 
            340                 345                 350         


Asp Met Ser Ser Pro Thr Gln Arg Thr Tyr Ser Ser Ser Leu Lys Arg 
        355                 360                 365             


Ser Ser Pro Arg Thr Ile Ser Phe Arg Met Lys Pro Lys Lys Glu Asn 
    370                 375                 380                 


Ser Glu Thr Thr Leu Thr Arg Ser Ala Ser Met Lys Leu Pro Asp Asn 
385                 390                 395                 400 


Thr Val Lys Leu Gly Glu Lys Leu Glu Arg Tyr His Thr Ala Ile Arg 
                405                 410                 415     


Arg Ser Glu Ser Val Lys Ser Arg Gly Leu Pro Cys Thr Glu Leu Phe 
            420                 425                 430         


Val Ala Pro Val Gly Val Ala Ser Lys Arg His Leu Phe Glu Lys Glu 
        435                 440                 445             


Leu Ala Gly Gln Ser Arg Ala Glu Pro Ala Ser Ser Arg Lys Glu Asn 
    450                 455                 460                 


Leu Arg Leu Ser Gly Val Val Thr Ser Arg Leu Asn Leu Trp Ile Ser 
465                 470                 475                 480 


Arg Thr Gln Glu Ser Gly Asp Gln Asp Pro Gln Glu Ala Gln Lys Ala 
                485                 490                 495     


Ser Ser Ala Thr Glu Arg Thr Gln Trp Gly Gln Lys Ser Asp Ser Ser 
            500                 505                 510         


Leu Asp Ala Glu Val 
        515         


<210>  21
<211>  5460
<212>  DNA
<213>  Homo sapiens

<400>  21
cgggcgcagg gagccgccgc cggggctgta ggcgccaagg ccatgtccga ctcgtgggtc       60

ccgaactccg cctcgggcca ggacccaggg ggccgccgga gggcctgggc cgagctgctg      120

gcgggaaggg tcaagaggga aaaatataat cctgaaaggg cacagaaatt aaaggaatca      180

gctgtgcgcc tcctgcgaag ccatcaggac ctgaatgccc ttttgcttga ggtagaaggt      240

ccactgtgta aaaaattgtc tctcagcaaa gtgattgact gtgacagttc tgaggcctat      300

gctaatcatt ctagttcatt tataggctct gctttgcagg atcaagcctc aaggctgggg      360

gttcccgtgg gtattctctc agccgggatg gttgcctcta gcgtgggaca gatctgcacg      420

gctccagcgg agaccagtca ccctgtgctg ctgactgtgg agcagagaaa gaagctgtct      480

tccctgttag agtttgctca gtatttattg gcacacagta tgttctcccg tctttccttc      540

tgtcaagaat tatggaaaat acagagttct ttgttgcttg aagcggtgtg gcatcttcac      600

gtacaaggca ttgtgagcct gcaagagctg ctggaaagcc atcccgacat gcatgctgtg      660

ggatcgtggc tcttcaggaa tctgtgctgc ctttgtgaac agatggaagc atcctgccag      720

catgctgacg tcgccagggc catgctttct gattttgttc aaatgtttgt tttgagggga      780

tttcagaaaa actcagatct gagaagaact gtggagcctg aaaaaatgcc gcaggtcacg      840

gttgatgtac tgcagagaat gctgattttt gcacttgacg ctttggctgc tggagtacag      900

gaggagtcct ccactcacaa gatcgtgagg tgctggttcg gagtgttcag tggacacacg      960

cttggcagtg taatttccac agatcctctg aagaggttct tcagtcatac cctgactcag     1020

atactcactc acagccctgt gctgaaagca tctgatgctg ttcagatgca gagagagtgg     1080

agctttgcgc ggacacaccc tctgctcacc tcactgtacc gcaggctctt tgtgatgctg     1140

agtgcagagg agttggttgg ccatttgcaa gaagttctgg aaacgcagga ggttcactgg     1200

cagagagtgc tctcctttgt gtctgccctg gttgtctgct ttccagaagc gcagcagctg     1260

cttgaagact gggtggcgcg tttgatggcc caggcattcg agagctgcca gctggacagc     1320

atggtcactg cgttcctggt tgtgcgccag gcagcactgg agggcccctc tgcgttcctg     1380

tcatatgcag actggttcaa ggcctccttt gggagcacac gaggctacca tggctgcagc     1440

aagaaggccc tggtcttcct gtttacgttc ttgtcagaac tcgtgccttt tgagtctccc     1500

cggtacctgc aggtgcacat tctccaccca cccctggttc ccggcaagta ccgctccctc     1560

ctcacagact acatctcatt ggccaagaca cggctggccg acctcaaggt ttctatagaa     1620

aacatgggac tctacgagga tttgtcatca gctggggaca ttactgagcc ccacagccaa     1680

gctcttcagg atgttgaaaa ggccatcatg gtgtttgagc atacggggaa catcccagtc     1740

accgtcatgg aggccagcat attcaggagg ccttactacg tgtcccactt cctccccgcc     1800

ctgctcacac ctcgagtgct ccccaaagtc cctgactccc gtgtggcgtt tatagagtct     1860

ctgaagagag cagataaaat ccccccatct ctgtactcca cctactgcca ggcctgctct     1920

gctgctgaag agaagccaga agatgcagcc ctgggagtga gggcagaacc caactctgct     1980

gaggagcccc tgggacagct cacagctgca ctgggagagc tgagagcctc catgacagac     2040

cccagccagc gtgatgttat atcggcacag gtggcagtga tttctgaaag actgagggct     2100

gtcctgggcc acaatgagga tgacagcagc gttgagatat caaagattca gctcagcatc     2160

aacacgccga gactggagcc acgggaacac atggctgtgg acctcctgct gacgtctttc     2220

tgtcagaacc tgatggctgc ctccagtgtc gctcccccgg agaggcaggg tccctgggct     2280

gccctcttcg tgaggaccat gtgtggacgt gtgctccctg cagtgctcac ccggctctgc     2340

cagctgctcc gtcaccaggg cccgagcctg agtgccccac atgtgctggg gttggctgcc     2400

ctggccgtgc acctgggtga gtccaggtct gcgctcccag aggtggatgt gggtcctcct     2460

gcacctggtg ctggccttcc tgtccctgcg ctctttgaca gcctcctgac ctgtaggacg     2520

agggattcct tgttcttctg cctgaaattt tgtacagcag caatttctta ctctctctgc     2580

aagttttctt cccagtcacg agatactttg tgcagctgct tatctccagg ccttattaaa     2640

aagtttcagt tcctcatgtt cagattgttc tcagaggccc gacagcctct ttctgaggag     2700

gacgtagcca gcctttcctg gagacccttg caccttcctt ctgcagactg gcagagagct     2760

gccctctctc tctggacaca cagaaccttc cgagaggtgt tgaaagagga agatgttcac     2820

ttaacttacc aagactggtt acacctggag ctggaaattc aacctgaagc tgatgctctt     2880

tcagatactg aacggcagga cttccaccag tgggcgatcc atgagcactt tctccctgag     2940

tcctcggctt cagggggctg tgacggagac ctgcaggctg cgtgtaccat tcttgtcaac     3000

gcactgatgg atttccacca aagctcaagg agttatgacc actcagaaaa ttctgatttg     3060

gtctttggtg gccgcacagg aaatgaggat attatttcca gattgcagga gatggtagct     3120

gacctggagc tgcagcaaga cctcatagtg cctctcggcc acaccccttc ccaggagcac     3180

ttcctctttg agattttccg cagacggctc caggctctga caagcgggtg gagcgtggct     3240

gccagccttc agagacagag ggagctgcta atgtacaaac ggatcctcct ccgcctgcct     3300

tcgtctgtcc tctgcggcag cagcttccag gcagaacagc ccatcactgc cagatgcgag     3360

cagttcttcc acttggtcaa ctctgagatg agaaacttct gctcccacgg aggtgccctg     3420

acacaggaca tcactgccca cttcttcagg ggcctcctga acgcctgtct gcggagcaga     3480

gacccctccc tgatggtcga cttcatactg gccaagtgcc agacgaaatg ccccttaatt     3540

ttgacctctg ctctggtgtg gtggccgagc ctggagcctg tgctgctctg ccggtggagg     3600

agacactgcc agagcccgct gccccgggaa ctgcagaagc tacaagaagg ccggcagttt     3660

gccagcgatt tcctctcccc tgaggctgcc tccccagcac ccaacccgga ctggctctca     3720

gctgctgcac tgcactttgc gattcaacaa gtcagggaag aaaacatcag gaagcagcta     3780

aagaagctgg actgcgagag agaggagcta ttggttttcc ttttcttctt ctccttgatg     3840

ggcctgctgt cgtcacatct gacctcaaat agcaccacag acctgccaaa ggctttccac     3900

gtttgtgcag caatcctcga gtgtttagag aagaggaaga tatcctggct ggcactcttt     3960

cagttgacag agagtgacct caggctgggg cggctcctcc tccgtgtggc cccggatcag     4020

cacaccaggc tgctgccttt cgctttttac agtcttctct cctacttcca tgaagacgcg     4080

gccatcaggg aagaggcctt cctgcatgtt gctgtggaca tgtacttgaa gctggtccag     4140

ctcttcgtgg ctggggatac aagcacagtt tcacctccag ctggcaggag cctggagctc     4200

aagggtcagg gcaaccccgt ggaactgata acaaaagctc gtctttttct gctgcagtta     4260

atacctcggt gcccgaaaaa gagcttctca cacgtggcag agctgctggc tgatcgtggg     4320

gactgcgacc cagaggtgag cgccgccctc cagagcagac agcaggctgc ccctgacgct     4380

gacctgtccc aggagcctca tctcttctga cgggacctgc cactgcacac cagcccagct     4440

cccgtgtaaa taatttatta caagcataac atggagctct tgttgcacta aaaagtggat     4500

tacaaatctc ctcgactgct ttagtgggga aaggaatcaa ttatttatga actgtccggc     4560

cccgagtcac tcagcgtttg cgggaaaata aaccactggt cccagagcag aggaaggcta     4620

cttgagccgg acaccaagcc cgcctccagc accaagggcg ggcagcaccc tccgaccctc     4680

ccatgcgggt gcacacgaag ggtgaggctg acacagccac tgcggagtcc aggctgctag     4740

aggtgctcat cctcactgcc gtcctcaggt gggttcgggc ttcaccgcct ggccctctgt     4800

ggtcacagag gggctcggtg gcccaggtgg tggttccgcc tccaggggca gggccttgtc     4860

ctgggtctgt gtcagcgggt gcaccatgga catgtgtaca ttgaggttgt gggccttctc     4920

aaaccgccgg ccacactggt cacaggcaaa gtccagctca gtctcagcct tgtgtttggt     4980

catgtggtac ttgagggatg cccgctgcct gcactggaac ccacagacct cacacctggg     5040

ggacagaggc agataagaag gtgcgagggc cacagccctg ggagggggtc ctgactcaca     5100

cttactgcaa aggcttggct cccgaatgtc gcatttggtg gacgagaagg tgcttccgct     5160

gcttgaaggt ttgtccacat tcgtcacaga tatagttccg cacctctgag aggggagagt     5220

ccagtgagtc caggcccctg atgctccaac ctcccggggg gacgacgatg acaatgtgaa     5280

accatcacag ctgggaagac atttctgcac atggttcacc atgcagtggg cccaagcaag     5340

gggcctatga gggcctcgtt tattaagatc tttaaactgc tttatacact gtcacgtggc     5400

ttcatcagct gtgtgcattt caggatggtt tttaaagaaa cctcagaaag ctatttcctt     5460


<210>  22
<211>  1455
<212>  PRT
<213>  Homo sapiens

<400>  22

Met Ser Asp Ser Trp Val Pro Asn Ser Ala Ser Gly Gln Asp Pro Gly 
1               5                   10                  15      


Gly Arg Arg Arg Ala Trp Ala Glu Leu Leu Ala Gly Arg Val Lys Arg 
            20                  25                  30          


Glu Lys Tyr Asn Pro Glu Arg Ala Gln Lys Leu Lys Glu Ser Ala Val 
        35                  40                  45              


Arg Leu Leu Arg Ser His Gln Asp Leu Asn Ala Leu Leu Leu Glu Val 
    50                  55                  60                  


Glu Gly Pro Leu Cys Lys Lys Leu Ser Leu Ser Lys Val Ile Asp Cys 
65                  70                  75                  80  


Asp Ser Ser Glu Ala Tyr Ala Asn His Ser Ser Ser Phe Ile Gly Ser 
                85                  90                  95      


Ala Leu Gln Asp Gln Ala Ser Arg Leu Gly Val Pro Val Gly Ile Leu 
            100                 105                 110         


Ser Ala Gly Met Val Ala Ser Ser Val Gly Gln Ile Cys Thr Ala Pro 
        115                 120                 125             


Ala Glu Thr Ser His Pro Val Leu Leu Thr Val Glu Gln Arg Lys Lys 
    130                 135                 140                 


Leu Ser Ser Leu Leu Glu Phe Ala Gln Tyr Leu Leu Ala His Ser Met 
145                 150                 155                 160 


Phe Ser Arg Leu Ser Phe Cys Gln Glu Leu Trp Lys Ile Gln Ser Ser 
                165                 170                 175     


Leu Leu Leu Glu Ala Val Trp His Leu His Val Gln Gly Ile Val Ser 
            180                 185                 190         


Leu Gln Glu Leu Leu Glu Ser His Pro Asp Met His Ala Val Gly Ser 
        195                 200                 205             


Trp Leu Phe Arg Asn Leu Cys Cys Leu Cys Glu Gln Met Glu Ala Ser 
    210                 215                 220                 


Cys Gln His Ala Asp Val Ala Arg Ala Met Leu Ser Asp Phe Val Gln 
225                 230                 235                 240 


Met Phe Val Leu Arg Gly Phe Gln Lys Asn Ser Asp Leu Arg Arg Thr 
                245                 250                 255     


Val Glu Pro Glu Lys Met Pro Gln Val Thr Val Asp Val Leu Gln Arg 
            260                 265                 270         


Met Leu Ile Phe Ala Leu Asp Ala Leu Ala Ala Gly Val Gln Glu Glu 
        275                 280                 285             


Ser Ser Thr His Lys Ile Val Arg Cys Trp Phe Gly Val Phe Ser Gly 
    290                 295                 300                 


His Thr Leu Gly Ser Val Ile Ser Thr Asp Pro Leu Lys Arg Phe Phe 
305                 310                 315                 320 


Ser His Thr Leu Thr Gln Ile Leu Thr His Ser Pro Val Leu Lys Ala 
                325                 330                 335     


Ser Asp Ala Val Gln Met Gln Arg Glu Trp Ser Phe Ala Arg Thr His 
            340                 345                 350         


Pro Leu Leu Thr Ser Leu Tyr Arg Arg Leu Phe Val Met Leu Ser Ala 
        355                 360                 365             


Glu Glu Leu Val Gly His Leu Gln Glu Val Leu Glu Thr Gln Glu Val 
    370                 375                 380                 


His Trp Gln Arg Val Leu Ser Phe Val Ser Ala Leu Val Val Cys Phe 
385                 390                 395                 400 


Pro Glu Ala Gln Gln Leu Leu Glu Asp Trp Val Ala Arg Leu Met Ala 
                405                 410                 415     


Gln Ala Phe Glu Ser Cys Gln Leu Asp Ser Met Val Thr Ala Phe Leu 
            420                 425                 430         


Val Val Arg Gln Ala Ala Leu Glu Gly Pro Ser Ala Phe Leu Ser Tyr 
        435                 440                 445             


Ala Asp Trp Phe Lys Ala Ser Phe Gly Ser Thr Arg Gly Tyr His Gly 
    450                 455                 460                 


Cys Ser Lys Lys Ala Leu Val Phe Leu Phe Thr Phe Leu Ser Glu Leu 
465                 470                 475                 480 


Val Pro Phe Glu Ser Pro Arg Tyr Leu Gln Val His Ile Leu His Pro 
                485                 490                 495     


Pro Leu Val Pro Gly Lys Tyr Arg Ser Leu Leu Thr Asp Tyr Ile Ser 
            500                 505                 510         


Leu Ala Lys Thr Arg Leu Ala Asp Leu Lys Val Ser Ile Glu Asn Met 
        515                 520                 525             


Gly Leu Tyr Glu Asp Leu Ser Ser Ala Gly Asp Ile Thr Glu Pro His 
    530                 535                 540                 


Ser Gln Ala Leu Gln Asp Val Glu Lys Ala Ile Met Val Phe Glu His 
545                 550                 555                 560 


Thr Gly Asn Ile Pro Val Thr Val Met Glu Ala Ser Ile Phe Arg Arg 
                565                 570                 575     


Pro Tyr Tyr Val Ser His Phe Leu Pro Ala Leu Leu Thr Pro Arg Val 
            580                 585                 590         


Leu Pro Lys Val Pro Asp Ser Arg Val Ala Phe Ile Glu Ser Leu Lys 
        595                 600                 605             


Arg Ala Asp Lys Ile Pro Pro Ser Leu Tyr Ser Thr Tyr Cys Gln Ala 
    610                 615                 620                 


Cys Ser Ala Ala Glu Glu Lys Pro Glu Asp Ala Ala Leu Gly Val Arg 
625                 630                 635                 640 


Ala Glu Pro Asn Ser Ala Glu Glu Pro Leu Gly Gln Leu Thr Ala Ala 
                645                 650                 655     


Leu Gly Glu Leu Arg Ala Ser Met Thr Asp Pro Ser Gln Arg Asp Val 
            660                 665                 670         


Ile Ser Ala Gln Val Ala Val Ile Ser Glu Arg Leu Arg Ala Val Leu 
        675                 680                 685             


Gly His Asn Glu Asp Asp Ser Ser Val Glu Ile Ser Lys Ile Gln Leu 
    690                 695                 700                 


Ser Ile Asn Thr Pro Arg Leu Glu Pro Arg Glu His Met Ala Val Asp 
705                 710                 715                 720 


Leu Leu Leu Thr Ser Phe Cys Gln Asn Leu Met Ala Ala Ser Ser Val 
                725                 730                 735     


Ala Pro Pro Glu Arg Gln Gly Pro Trp Ala Ala Leu Phe Val Arg Thr 
            740                 745                 750         


Met Cys Gly Arg Val Leu Pro Ala Val Leu Thr Arg Leu Cys Gln Leu 
        755                 760                 765             


Leu Arg His Gln Gly Pro Ser Leu Ser Ala Pro His Val Leu Gly Leu 
    770                 775                 780                 


Ala Ala Leu Ala Val His Leu Gly Glu Ser Arg Ser Ala Leu Pro Glu 
785                 790                 795                 800 


Val Asp Val Gly Pro Pro Ala Pro Gly Ala Gly Leu Pro Val Pro Ala 
                805                 810                 815     


Leu Phe Asp Ser Leu Leu Thr Cys Arg Thr Arg Asp Ser Leu Phe Phe 
            820                 825                 830         


Cys Leu Lys Phe Cys Thr Ala Ala Ile Ser Tyr Ser Leu Cys Lys Phe 
        835                 840                 845             


Ser Ser Gln Ser Arg Asp Thr Leu Cys Ser Cys Leu Ser Pro Gly Leu 
    850                 855                 860                 


Ile Lys Lys Phe Gln Phe Leu Met Phe Arg Leu Phe Ser Glu Ala Arg 
865                 870                 875                 880 


Gln Pro Leu Ser Glu Glu Asp Val Ala Ser Leu Ser Trp Arg Pro Leu 
                885                 890                 895     


His Leu Pro Ser Ala Asp Trp Gln Arg Ala Ala Leu Ser Leu Trp Thr 
            900                 905                 910         


His Arg Thr Phe Arg Glu Val Leu Lys Glu Glu Asp Val His Leu Thr 
        915                 920                 925             


Tyr Gln Asp Trp Leu His Leu Glu Leu Glu Ile Gln Pro Glu Ala Asp 
    930                 935                 940                 


Ala Leu Ser Asp Thr Glu Arg Gln Asp Phe His Gln Trp Ala Ile His 
945                 950                 955                 960 


Glu His Phe Leu Pro Glu Ser Ser Ala Ser Gly Gly Cys Asp Gly Asp 
                965                 970                 975     


Leu Gln Ala Ala Cys Thr Ile Leu Val Asn Ala Leu Met Asp Phe His 
            980                 985                 990         


Gln Ser Ser Arg Ser Tyr Asp His  Ser Glu Asn Ser Asp  Leu Val Phe 
        995                 1000                 1005             


Gly Gly  Arg Thr Gly Asn Glu  Asp Ile Ile Ser Arg  Leu Gln Glu 
    1010                 1015                 1020             


Met Val  Ala Asp Leu Glu Leu  Gln Gln Asp Leu Ile  Val Pro Leu 
    1025                 1030                 1035             


Gly His  Thr Pro Ser Gln Glu  His Phe Leu Phe Glu  Ile Phe Arg 
    1040                 1045                 1050             


Arg Arg  Leu Gln Ala Leu Thr  Ser Gly Trp Ser Val  Ala Ala Ser 
    1055                 1060                 1065             


Leu Gln  Arg Gln Arg Glu Leu  Leu Met Tyr Lys Arg  Ile Leu Leu 
    1070                 1075                 1080             


Arg Leu  Pro Ser Ser Val Leu  Cys Gly Ser Ser Phe  Gln Ala Glu 
    1085                 1090                 1095             


Gln Pro  Ile Thr Ala Arg Cys  Glu Gln Phe Phe His  Leu Val Asn 
    1100                 1105                 1110             


Ser Glu  Met Arg Asn Phe Cys  Ser His Gly Gly Ala  Leu Thr Gln 
    1115                 1120                 1125             


Asp Ile  Thr Ala His Phe Phe  Arg Gly Leu Leu Asn  Ala Cys Leu 
    1130                 1135                 1140             


Arg Ser  Arg Asp Pro Ser Leu  Met Val Asp Phe Ile  Leu Ala Lys 
    1145                 1150                 1155             


Cys Gln  Thr Lys Cys Pro Leu  Ile Leu Thr Ser Ala  Leu Val Trp 
    1160                 1165                 1170             


Trp Pro  Ser Leu Glu Pro Val  Leu Leu Cys Arg Trp  Arg Arg His 
    1175                 1180                 1185             


Cys Gln  Ser Pro Leu Pro Arg  Glu Leu Gln Lys Leu  Gln Glu Gly 
    1190                 1195                 1200             


Arg Gln  Phe Ala Ser Asp Phe  Leu Ser Pro Glu Ala  Ala Ser Pro 
    1205                 1210                 1215             


Ala Pro  Asn Pro Asp Trp Leu  Ser Ala Ala Ala Leu  His Phe Ala 
    1220                 1225                 1230             


Ile Gln  Gln Val Arg Glu Glu  Asn Ile Arg Lys Gln  Leu Lys Lys 
    1235                 1240                 1245             


Leu Asp  Cys Glu Arg Glu Glu  Leu Leu Val Phe Leu  Phe Phe Phe 
    1250                 1255                 1260             


Ser Leu  Met Gly Leu Leu Ser  Ser His Leu Thr Ser  Asn Ser Thr 
    1265                 1270                 1275             


Thr Asp  Leu Pro Lys Ala Phe  His Val Cys Ala Ala  Ile Leu Glu 
    1280                 1285                 1290             


Cys Leu  Glu Lys Arg Lys Ile  Ser Trp Leu Ala Leu  Phe Gln Leu 
    1295                 1300                 1305             


Thr Glu  Ser Asp Leu Arg Leu  Gly Arg Leu Leu Leu  Arg Val Ala 
    1310                 1315                 1320             


Pro Asp  Gln His Thr Arg Leu  Leu Pro Phe Ala Phe  Tyr Ser Leu 
    1325                 1330                 1335             


Leu Ser  Tyr Phe His Glu Asp  Ala Ala Ile Arg Glu  Glu Ala Phe 
    1340                 1345                 1350             


Leu His  Val Ala Val Asp Met  Tyr Leu Lys Leu Val  Gln Leu Phe 
    1355                 1360                 1365             


Val Ala  Gly Asp Thr Ser Thr  Val Ser Pro Pro Ala  Gly Arg Ser 
    1370                 1375                 1380             


Leu Glu  Leu Lys Gly Gln Gly  Asn Pro Val Glu Leu  Ile Thr Lys 
    1385                 1390                 1395             


Ala Arg  Leu Phe Leu Leu Gln  Leu Ile Pro Arg Cys  Pro Lys Lys 
    1400                 1405                 1410             


Ser Phe  Ser His Val Ala Glu  Leu Leu Ala Asp Arg  Gly Asp Cys 
    1415                 1420                 1425             


Asp Pro  Glu Val Ser Ala Ala  Leu Gln Ser Arg Gln  Gln Ala Ala 
    1430                 1435                 1440             


Pro Asp  Ala Asp Leu Ser Gln  Glu Pro His Leu Phe  
    1445                 1450                 1455 


<210>  23
<211>  4612
<212>  DNA
<213>  Homo sapiens

<400>  23
agaatgcact gctgacacgt gtgcgcgcgc gcggctccac tgccgggcga ccgcgggaaa       60

attccaaaaa aactcaaaaa gccaatacga ggcaaagcca aattttcaag ccacagatcc      120

cgggcggtgg cttcctttcc gccactgccc aaactgctga agcagctccc gcgaggacca      180

cccgatttaa tgtgtgccga ccatttcctt cagtgctgga caggctgctg tgaagggaca      240

tcaccttttc gctttttcca agatggctca agattcagta gatctttctt gtgattatca      300

gttttggatg cagaagcttt ctgtatggga tcaggcttcc actttggaaa cccagcaaga      360

cacctgtctt cacgtggctc agttccagga gttcctaagg aagatgtatg aagccttgaa      420

agagatggat tctaatacag tcattgaaag attccccaca attggtcaac tgttggcaaa      480

agcttgttgg aatcctttta ttttagcata tgatgaaagc caaaaaattc taatatggtg      540

cttatgttgt ctaattaaca aagaaccaca gaattctgga caatcaaaac ttaactcctg      600

gatacagggt gtattatctc atatactttc agcactcaga tttgataaag aagttgctct      660

tttcactcaa ggtcttgggt atgcacctat agattactat cctggtttgc ttaaaaatat      720

ggttttatca ttagcgtctg aactcagaga gaatcatctt aatggattta acactcaaag      780

gcgaatggct cccgagcgag tggcgtccct gtcacgagtt tgtgtcccac ttattaccct      840

gacagatgtt gaccccctgg tggaggctct cctcatctgt catggacgtg aacctcagga      900

aatcctccag ccagagttct ttgaggctgt aaacgaggcc attttgctga agaagatttc      960

tctccccatg tcagctgtag tctgcctctg gcttcggcac cttcccagcc ttgaaaaagc     1020

aatgctgcat ctttttgaaa agctaatctc cagtgagaga aattgtctga gaaggatcga     1080

atgctttata aaagattcat cgctgcctca agcagcctgc caccctgcca tattccgggt     1140

tgttgatgag atgttcaggt gtgcactcct ggaaaccgat ggggccctgg aaatcatagc     1200

cactattcag gtgtttacgc agtgctttgt agaagctctg gagaaagcaa gcaagcagct     1260

gcggtttgca ctcaagacct actttcctta cacttctcca tctcttgcca tggtgctgct     1320

gcaagaccct caagatatcc ctcggggaca ctggctccag acactgaagc atatttctga     1380

actgctcaga gaagcagttg aagaccagac tcatgggtcc tgcggaggtc cctttgagag     1440

ctggttcctg ttcattcact tcggaggatg ggctgagatg gtggcagagc aattactgat     1500

gtcggcagcc gaacccccca cggccctgct gtggctcttg gccttctact acggcccccg     1560

tgatgggagg cagcagagag cacagactat ggtccaggtg aaggccgtgc tgggccacct     1620

cctggcaatg tccagaagca gcagcctctc agcccaggac ctgcagacgg tagcaggaca     1680

gggcacagac acagacctca gagctcctgc acaacagctg atcaggcacc ttctcctcaa     1740

cttcctgctc tgggctcctg gaggccacac gatcgcctgg gatgtcatca ccctgatggc     1800

tcacactgct gagataactc acgagatcat tggctttctt gaccagacct tgtacagatg     1860

gaatcgtctt ggcattgaaa gccctagatc agaaaaactg gcccgagagc tccttaaaga     1920

gctgcgaact caagtctaga aggcacgcag gccgtgtggg tgcccggcgt gagggatcag     1980

gctcgccagg gccacaggac aggtgatgac ctgtggccac gcatttgtgg agtaagtgcc     2040

ctcgctgggc tgtgagaatg agctgtacac atcttgggac aatctgctag tatctatttt     2100

acaaaatgca gagccaggtc cctcagccca gactcagtca gacatgttca ctaatgactc     2160

aagtgagcct tcggtactcc tggtgcccgc ccggccagac cgtcagcttg ataattacta     2220

aagcaaaggc ctgggtggga gaacaggttt ctagttttta cccaagtcaa gctgcacatc     2280

tattatttaa aaattcaaag tcttagaacc aagaatttgg tcatgaacca ttaaagaatt     2340

tagagagaac ttagctcttt ttagactctt tttaggagtc agggatctgg gataaagcca     2400

cactgtcttg ctgtatggag aaattcttca aggggagtca gggtccctca ggcttccctt     2460

gtgtctccct ggacctgcct gacaggccac aggagcagac agcacaccca agcccgggcc     2520

tccggcacac tctttccact ctgtatttgc taaatgatgc taactgctac caaaaggccc     2580

ttgggacatc agaggagccg gcaggcgaag gtagaggatg tgttccagaa acattagaag     2640

gcaggattaa ttcagttagt tagttctctt gttaaatgga aatgggaatt ggaaattcct     2700

gataaagaat tggcctggct gggtgcagtg gctcacacct gtgatcccag cactttggga     2760

ggccaaggca gggggattac ttcagcccag gagttccaga ctgcctggct aacatggcaa     2820

taccctatct ctactaaaaa tacaaaaatt atcggggtgc aatggcatgc atctgtaatc     2880

ccagctattc aagaggctga ggcatgagga tctcttgaac ccgggaggtg ggagttgtag     2940

tgagccgaga tcatgacact gcactccagc ctgggcaaca gagcgagacc atctcttaaa     3000

aaaaggcatt gttagtgtaa tctcaaggtt aacatttatt tcatgtcagt acagggtgct     3060

ttttcctttc agggacattc tggaattgta ttggttgtac attcttttgt gtctattctg     3120

tttgtcaagt gagtcaagac ttgcttttgt ccattttgat ttgtgtgtat tagtctgagt     3180

cttggctccg ttttgaggta tgagcaaagt tttgctggat tagaagttaa cctttaggga     3240

aattccttat tttggtatgt ggcaatgcta atagatccac tgaagatctg gaaaattcca     3300

ggaacttttc acctgagcct ttcttctgag aaatgctgca gtcagaaggg tgtgctggta     3360

aagtattttg gtggcagctg ccatcatggt cattgccttc atataacatg cttcgtgctc     3420

atggtcattg ccttcatata acatgcttcg tgccatcatg atccttgcct tcatataaca     3480

aacatgcttc gtcagaggtg ttggggttga aaaaggagct gcatgcttca ctggagttga     3540

gggcctctct cctgttctga ctttaagcca gaacttgtgg ctgggccatg gaagctgtga     3600

ctcctctgtg gacatggtgg cagcagggaa cccctagaga gaggggccac tgggaccagg     3660

cctcctgttg tggagggact cctgggacag tcctccaccc tgtcctgtgg tcctgtgtac     3720

agggttggcc tcttcctcct cccctgccag gcctctgccc atgccccttc cttccttctc     3780

ctgggactgg tgaagctagg catctggaag acttcttcct agcctggaag ccctgacctc     3840

ggcccatctg cagaatctcc cagttccttc acagctgccg agtcctctca cgggtgcggt     3900

ggaggcggcc ttgccggtgg tgctttctgg gcagccaggg gttcctgggt gggaggactg     3960

tccctctggg gacgtggcac tgaagtgcct gctggcttca tgtggccctt tgccctttcc     4020

cagcctgaga gatgctcaaa ggtggggagc tgggggagcc acccctcggc cattccctcc     4080

acctccaaga caggtggcgg ccgggcaggc actcttaagc ccacctcccc ctcttgttgc     4140

cttcgatttc ggcaaagcct gggcaggtgc caccgggaag gaatggcatc cgagatgctg     4200

ggcggggacg cggcgtggcc gagggggcct tgacggcgtt ggcggggcct gggcacaggg     4260

gcagccgcag ggaggcaggg atggcaaggc gtgaagccac cctggaagga actggaccaa     4320

ggtcttcaga ggtgcgacag ggtctggaat ctgaccttac tctagcagga gtttttgtag     4380

actctccctg atagtttagt ttttgataaa gcatgctggt aaaaccacta ccctcagaga     4440

gagccaaaaa tacagaagag gcggagagcg cccctccaac caggctgtta ttcccctgga     4500

ctccgtgaca tctgtggaat tttttagctc tttaaaatct gtaatttgtt gtctattttt     4560

tcattctaaa taaaacttca gtttgcacct aaaaaaaaaa aaaaaaaaaa aa             4612


<210>  24
<211>  558
<212>  PRT
<213>  Homo sapiens

<400>  24

Met Ala Gln Asp Ser Val Asp Leu Ser Cys Asp Tyr Gln Phe Trp Met 
1               5                   10                  15      


Gln Lys Leu Ser Val Trp Asp Gln Ala Ser Thr Leu Glu Thr Gln Gln 
            20                  25                  30          


Asp Thr Cys Leu His Val Ala Gln Phe Gln Glu Phe Leu Arg Lys Met 
        35                  40                  45              


Tyr Glu Ala Leu Lys Glu Met Asp Ser Asn Thr Val Ile Glu Arg Phe 
    50                  55                  60                  


Pro Thr Ile Gly Gln Leu Leu Ala Lys Ala Cys Trp Asn Pro Phe Ile 
65                  70                  75                  80  


Leu Ala Tyr Asp Glu Ser Gln Lys Ile Leu Ile Trp Cys Leu Cys Cys 
                85                  90                  95      


Leu Ile Asn Lys Glu Pro Gln Asn Ser Gly Gln Ser Lys Leu Asn Ser 
            100                 105                 110         


Trp Ile Gln Gly Val Leu Ser His Ile Leu Ser Ala Leu Arg Phe Asp 
        115                 120                 125             


Lys Glu Val Ala Leu Phe Thr Gln Gly Leu Gly Tyr Ala Pro Ile Asp 
    130                 135                 140                 


Tyr Tyr Pro Gly Leu Leu Lys Asn Met Val Leu Ser Leu Ala Ser Glu 
145                 150                 155                 160 


Leu Arg Glu Asn His Leu Asn Gly Phe Asn Thr Gln Arg Arg Met Ala 
                165                 170                 175     


Pro Glu Arg Val Ala Ser Leu Ser Arg Val Cys Val Pro Leu Ile Thr 
            180                 185                 190         


Leu Thr Asp Val Asp Pro Leu Val Glu Ala Leu Leu Ile Cys His Gly 
        195                 200                 205             


Arg Glu Pro Gln Glu Ile Leu Gln Pro Glu Phe Phe Glu Ala Val Asn 
    210                 215                 220                 


Glu Ala Ile Leu Leu Lys Lys Ile Ser Leu Pro Met Ser Ala Val Val 
225                 230                 235                 240 


Cys Leu Trp Leu Arg His Leu Pro Ser Leu Glu Lys Ala Met Leu His 
                245                 250                 255     


Leu Phe Glu Lys Leu Ile Ser Ser Glu Arg Asn Cys Leu Arg Arg Ile 
            260                 265                 270         


Glu Cys Phe Ile Lys Asp Ser Ser Leu Pro Gln Ala Ala Cys His Pro 
        275                 280                 285             


Ala Ile Phe Arg Val Val Asp Glu Met Phe Arg Cys Ala Leu Leu Glu 
    290                 295                 300                 


Thr Asp Gly Ala Leu Glu Ile Ile Ala Thr Ile Gln Val Phe Thr Gln 
305                 310                 315                 320 


Cys Phe Val Glu Ala Leu Glu Lys Ala Ser Lys Gln Leu Arg Phe Ala 
                325                 330                 335     


Leu Lys Thr Tyr Phe Pro Tyr Thr Ser Pro Ser Leu Ala Met Val Leu 
            340                 345                 350         


Leu Gln Asp Pro Gln Asp Ile Pro Arg Gly His Trp Leu Gln Thr Leu 
        355                 360                 365             


Lys His Ile Ser Glu Leu Leu Arg Glu Ala Val Glu Asp Gln Thr His 
    370                 375                 380                 


Gly Ser Cys Gly Gly Pro Phe Glu Ser Trp Phe Leu Phe Ile His Phe 
385                 390                 395                 400 


Gly Gly Trp Ala Glu Met Val Ala Glu Gln Leu Leu Met Ser Ala Ala 
                405                 410                 415     


Glu Pro Pro Thr Ala Leu Leu Trp Leu Leu Ala Phe Tyr Tyr Gly Pro 
            420                 425                 430         


Arg Asp Gly Arg Gln Gln Arg Ala Gln Thr Met Val Gln Val Lys Ala 
        435                 440                 445             


Val Leu Gly His Leu Leu Ala Met Ser Arg Ser Ser Ser Leu Ser Ala 
    450                 455                 460                 


Gln Asp Leu Gln Thr Val Ala Gly Gln Gly Thr Asp Thr Asp Leu Arg 
465                 470                 475                 480 


Ala Pro Ala Gln Gln Leu Ile Arg His Leu Leu Leu Asn Phe Leu Leu 
                485                 490                 495     


Trp Ala Pro Gly Gly His Thr Ile Ala Trp Asp Val Ile Thr Leu Met 
            500                 505                 510         


Ala His Thr Ala Glu Ile Thr His Glu Ile Ile Gly Phe Leu Asp Gln 
        515                 520                 525             


Thr Leu Tyr Arg Trp Asn Arg Leu Gly Ile Glu Ser Pro Arg Ser Glu 
    530                 535                 540                 


Lys Leu Ala Arg Glu Leu Leu Lys Glu Leu Arg Thr Gln Val 
545                 550                 555             


<210>  25
<211>  2649
<212>  DNA
<213>  Homo sapiens

<400>  25
aggaggacct gggggtgtgg cagcgaggaa gggccgagcc acggactgtg gggccgaaac       60

tcgctcccgc ccaccctttc tcgaggctgt ggcctccgcg agagccgagc gggccgcacc      120

gccggccgtg cgactgcccc agtcagacac gaccccggct tctagcccgc ctaagcctgt      180

ttggggttgc tgactcgttt cctccccgag tttcccgcgg gaactaactc ttcaagagga      240

ccaaccgcag cccagagctt cgcagacccg gccaaccaga ggcgaggttg agagcccggc      300

gggccgcggg gagagagcgt cccatctgtc ctggaaagcc tgggcgggtg gattgggacc      360

ccgagagaag caggggagct cggcggggtg cagaagtgcc caggcccctc cccgctgggg      420

ttgggagctt gggcaggcca gcttcaccct tcctaagtcc gcttctggtc tccgggccca      480

gcctcggcca ccatgtcccg ccagaccacc tctgtgggct ccagctgcct ggacctgtgg      540

agggaaaaga atgaccggct cgttcgacag gccaaggtgg ctcagaactc cggtctgact      600

ctgaggcgac agcagttggc tcaggatgca ctggaagggc tcagagggct cctccatagt      660

ctgcaagggc tccctgcagc tgttcctgtt cttcccttgg agctgactgt cacctgcaac      720

ttcattatcc tgagggcaag cttggcccag ggtttcacag aggatcaggc ccaggatatc      780

cagcggagcc tagagagagt gctggagaca caggagcagc aggggcccag gttggaacag      840

gggctcaggg agctgtggga ctctgtcctt cgtgcttcct gccttctgcc ggagctgctg      900

tctgccctgc accgcctggt tggcctgcag gctgccctct ggttgagtgc tgaccgtctt      960

ggggacctgg ccttgttact agagaccctg aatggcagcc agagtggagc ctctaaggat     1020

ctgctgttac ttctgaaaac ttggagtccc ccagctgagg aattagatgc tccattgacc     1080

ctgcaggatg cccagggatt gaaggatgtc ctcctgacag catttgccta ccgccaaggt     1140

ctccaggagc tgatcacagg gaacccagac aaggcactaa gcagccttca tgaagcggcc     1200

tcaggcctgt gtccacggcc tgtgttggtc caggtgtaca cagcactggg gtcctgtcac     1260

cgtaagatgg gaaatccaca gagagcactg ttgtacttgg ttgcagccct gaaagaggga     1320

tcagcctggg gtcctccact tctggaggcc tctaggctct atcagcaact gggggacaca     1380

acagcagagc tggagagtct ggagctgcta gttgaggcct tgaatgtccc atgcagttcc     1440

aaagccccgc agtttctcat tgaggtagaa ttactactgc caccacctga cctagcctca     1500

ccccttcatt gtggcactca gagccagacc aagcacatac tagcaagcag gtgcctacag     1560

acggggaggg caggagacgc tgcagagcat tacttggacc tgctggccct gttgctggat     1620

agctcggagc caaggttctc cccacccccc tcccctccag ggccctgtat gcctgaggtg     1680

tttttggagg cagcggtagc actgatccag gcaggcagag cccaagatgc cttgactcta     1740

tgtgaggagt tgctcagccg cacatcatct ctgctaccca agatgtcccg gctgtgggaa     1800

gatgccagaa aaggaaccaa ggaactgcca tactgcccac tctgggtctc tgccacccac     1860

ctgcttcagg gccaggcctg ggttcaactg ggtgcccaaa aagtggcaat tagtgaattt     1920

agcaggtgcc tcgagctgct cttccgggcc acacctgagg aaaaagaaca aggggcagct     1980

ttcaactgtg agcagggatg taagtcagat gcggcactgc agcagcttcg ggcagccgcc     2040

ctaattagtc gtggactgga atgggtagcc agcggccagg ataccaaagc cttacaggac     2100

ttcctcctca gtgtgcagat gtgcccaggt aatcgagaca cttactttca cctgcttcag     2160

actctgaaga ggctagatcg gagggatgag gccactgcac tctggtggag gctggaggcc     2220

caaactaagg ggtcacatga agatgctctg tggtctctcc ccctgtacct agaaagctat     2280

ttgagctgga tccgtccctc tgatcgtgac gccttccttg aagaatttcg gacatctctg     2340

ccaaagtctt gtgacctgta gctgccacgt tttgaagagc ttgagctggg tccccagtgg     2400

gctgtctctc tgtggggagg gctttctgct tcaccatcat taggaatgtg accattccta     2460

tataattcct ggactggtga gattggtggt aggcctgtga aatttgccct agttactacc     2520

attctcgttt tggaggaaac aatctctgcc accaccaagt cattgacttt gctcgaggca     2580

ccttttttcc tgtttctcct tttctgttgt cgagtaaaat ttcatattta taaaaaaaaa     2640

aaaaaaaaa                                                             2649


<210>  26
<211>  622
<212>  PRT
<213>  Homo sapiens

<400>  26

Met Ser Arg Gln Thr Thr Ser Val Gly Ser Ser Cys Leu Asp Leu Trp 
1               5                   10                  15      


Arg Glu Lys Asn Asp Arg Leu Val Arg Gln Ala Lys Val Ala Gln Asn 
            20                  25                  30          


Ser Gly Leu Thr Leu Arg Arg Gln Gln Leu Ala Gln Asp Ala Leu Glu 
        35                  40                  45              


Gly Leu Arg Gly Leu Leu His Ser Leu Gln Gly Leu Pro Ala Ala Val 
    50                  55                  60                  


Pro Val Leu Pro Leu Glu Leu Thr Val Thr Cys Asn Phe Ile Ile Leu 
65                  70                  75                  80  


Arg Ala Ser Leu Ala Gln Gly Phe Thr Glu Asp Gln Ala Gln Asp Ile 
                85                  90                  95      


Gln Arg Ser Leu Glu Arg Val Leu Glu Thr Gln Glu Gln Gln Gly Pro 
            100                 105                 110         


Arg Leu Glu Gln Gly Leu Arg Glu Leu Trp Asp Ser Val Leu Arg Ala 
        115                 120                 125             


Ser Cys Leu Leu Pro Glu Leu Leu Ser Ala Leu His Arg Leu Val Gly 
    130                 135                 140                 


Leu Gln Ala Ala Leu Trp Leu Ser Ala Asp Arg Leu Gly Asp Leu Ala 
145                 150                 155                 160 


Leu Leu Leu Glu Thr Leu Asn Gly Ser Gln Ser Gly Ala Ser Lys Asp 
                165                 170                 175     


Leu Leu Leu Leu Leu Lys Thr Trp Ser Pro Pro Ala Glu Glu Leu Asp 
            180                 185                 190         


Ala Pro Leu Thr Leu Gln Asp Ala Gln Gly Leu Lys Asp Val Leu Leu 
        195                 200                 205             


Thr Ala Phe Ala Tyr Arg Gln Gly Leu Gln Glu Leu Ile Thr Gly Asn 
    210                 215                 220                 


Pro Asp Lys Ala Leu Ser Ser Leu His Glu Ala Ala Ser Gly Leu Cys 
225                 230                 235                 240 


Pro Arg Pro Val Leu Val Gln Val Tyr Thr Ala Leu Gly Ser Cys His 
                245                 250                 255     


Arg Lys Met Gly Asn Pro Gln Arg Ala Leu Leu Tyr Leu Val Ala Ala 
            260                 265                 270         


Leu Lys Glu Gly Ser Ala Trp Gly Pro Pro Leu Leu Glu Ala Ser Arg 
        275                 280                 285             


Leu Tyr Gln Gln Leu Gly Asp Thr Thr Ala Glu Leu Glu Ser Leu Glu 
    290                 295                 300                 


Leu Leu Val Glu Ala Leu Asn Val Pro Cys Ser Ser Lys Ala Pro Gln 
305                 310                 315                 320 


Phe Leu Ile Glu Val Glu Leu Leu Leu Pro Pro Pro Asp Leu Ala Ser 
                325                 330                 335     


Pro Leu His Cys Gly Thr Gln Ser Gln Thr Lys His Ile Leu Ala Ser 
            340                 345                 350         


Arg Cys Leu Gln Thr Gly Arg Ala Gly Asp Ala Ala Glu His Tyr Leu 
        355                 360                 365             


Asp Leu Leu Ala Leu Leu Leu Asp Ser Ser Glu Pro Arg Phe Ser Pro 
    370                 375                 380                 


Pro Pro Ser Pro Pro Gly Pro Cys Met Pro Glu Val Phe Leu Glu Ala 
385                 390                 395                 400 


Ala Val Ala Leu Ile Gln Ala Gly Arg Ala Gln Asp Ala Leu Thr Leu 
                405                 410                 415     


Cys Glu Glu Leu Leu Ser Arg Thr Ser Ser Leu Leu Pro Lys Met Ser 
            420                 425                 430         


Arg Leu Trp Glu Asp Ala Arg Lys Gly Thr Lys Glu Leu Pro Tyr Cys 
        435                 440                 445             


Pro Leu Trp Val Ser Ala Thr His Leu Leu Gln Gly Gln Ala Trp Val 
    450                 455                 460                 


Gln Leu Gly Ala Gln Lys Val Ala Ile Ser Glu Phe Ser Arg Cys Leu 
465                 470                 475                 480 


Glu Leu Leu Phe Arg Ala Thr Pro Glu Glu Lys Glu Gln Gly Ala Ala 
                485                 490                 495     


Phe Asn Cys Glu Gln Gly Cys Lys Ser Asp Ala Ala Leu Gln Gln Leu 
            500                 505                 510         


Arg Ala Ala Ala Leu Ile Ser Arg Gly Leu Glu Trp Val Ala Ser Gly 
        515                 520                 525             


Gln Asp Thr Lys Ala Leu Gln Asp Phe Leu Leu Ser Val Gln Met Cys 
    530                 535                 540                 


Pro Gly Asn Arg Asp Thr Tyr Phe His Leu Leu Gln Thr Leu Lys Arg 
545                 550                 555                 560 


Leu Asp Arg Arg Asp Glu Ala Thr Ala Leu Trp Trp Arg Leu Glu Ala 
                565                 570                 575     


Gln Thr Lys Gly Ser His Glu Asp Ala Leu Trp Ser Leu Pro Leu Tyr 
            580                 585                 590         


Leu Glu Ser Tyr Leu Ser Trp Ile Arg Pro Ser Asp Arg Asp Ala Phe 
        595                 600                 605             


Leu Glu Glu Phe Arg Thr Ser Leu Pro Lys Ser Cys Asp Leu 
    610                 615                 620         


<210>  27
<211>  4683
<212>  DNA
<213>  adeno-associated virus 6

<400>  27
ttggccactc cctctctgcg cgctcgctcg ctcactgagg ccgggcgacc aaaggtcgcc       60

cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc gagcgcgcag agagggagtg      120

gccaactcca tcactagggg ttcctggagg ggtggagtcg tgacgtgaat tacgtcatag      180

ggttagggag gtcctgtatt agaggtcacg tgagtgtttt gcgacatttt gcgacaccat      240

gtggtcacgc tgggtattta agcccgagtg agcacgcagg gtctccattt tgaagcggga      300

ggtttgaacg cgcagcgcca tgccggggtt ttacgagatt gtgattaagg tccccagcga      360

ccttgacgag catctgcccg gcatttctga cagctttgtg aactgggtgg ccgagaagga      420

atgggagttg ccgccagatt ctgacatgga tctgaatctg attgagcagg cacccctgac      480

cgtggccgag aagctgcagc gcgacttcct ggtccagtgg cgccgcgtga gtaaggcccc      540

ggaggccctc ttctttgttc agttcgagaa gggcgagtcc tacttccacc tccatattct      600

ggtggagacc acgggggtca aatccatggt gctgggccgc ttcctgagtc agattaggga      660

caagctggtg cagaccatct accgcgggat cgagccgacc ctgcccaact ggttcgcggt      720

gaccaagacg cgtaatggcg ccggaggggg gaacaaggtg gtggacgagt gctacatccc      780

caactacctc ctgcccaaga ctcagcccga gctgcagtgg gcgtggacta acatggagga      840

gtatataagc gcgtgtttaa acctggccga gcgcaaacgg ctcgtggcgc acgacctgac      900

ccacgtcagc cagacccagg agcagaacaa ggagaatctg aaccccaatt ctgacgcgcc      960

tgtcatccgg tcaaaaacct ccgcacgcta catggagctg gtcgggtggc tggtggaccg     1020

gggcatcacc tccgagaagc agtggatcca ggaggaccag gcctcgtaca tctccttcaa     1080

cgccgcctcc aactcgcggt cccagatcaa ggccgctctg gacaatgccg gcaagatcat     1140

ggcgctgacc aaatccgcgc ccgactacct ggtaggcccc gctccgcccg ccgacattaa     1200

aaccaaccgc atttaccgca tcctggagct gaacggctac gaccctgcct acgccggctc     1260

cgtctttctc ggctgggccc agaaaaggtt cggaaaacgc aacaccatct ggctgtttgg     1320

gccggccacc acgggcaaga ccaacatcgc ggaagccatc gcccacgccg tgcccttcta     1380

cggctgcgtc aactggacca atgagaactt tcccttcaac gattgcgtcg acaagatggt     1440

gatctggtgg gaggagggca agatgacggc caaggtcgtg gagtccgcca aggccattct     1500

cggcggcagc aaggtgcgcg tggaccaaaa gtgcaagtcg tccgcccaga tcgatcccac     1560

ccccgtgatc gtcacctcca acaccaacat gtgcgccgtg attgacggga acagcaccac     1620

cttcgagcac cagcagccgt tgcaggaccg gatgttcaaa tttgaactca cccgccgtct     1680

ggagcatgac tttggcaagg tgacaaagca ggaagtcaaa gagttcttcc gctgggcgca     1740

ggatcacgtg accgaggtgg cgcatgagtt ctacgtcaga aagggtggag ccaacaagag     1800

acccgccccc gatgacgcgg ataaaagcga gcccaagcgg gcctgcccct cagtcgcgga     1860

tccatcgacg tcagacgcgg aaggagctcc ggtggacttt gccgacaggt accaaaacaa     1920

atgttctcgt cacgcgggca tgcttcagat gctgtttccc tgcaaaacat gcgagagaat     1980

gaatcagaat ttcaacattt gcttcacgca cgggaccaga gactgttcag aatgtttccc     2040

cggcgtgtca gaatctcaac cggtcgtcag aaagaggacg tatcggaaac tctgtgccat     2100

tcatcatctg ctggggcggg ctcccgagat tgcttgctcg gcctgcgatc tggtcaacgt     2160

ggatctggat gactgtgttt ctgagcaata aatgacttaa accaggtatg gctgccgatg     2220

gttatcttcc agattggctc gaggacaacc tctctgaggg cattcgcgag tggtgggact     2280

tgaaacctgg agccccgaaa cccaaagcca accagcaaaa gcaggacgac ggccggggtc     2340

tggtgcttcc tggctacaag tacctcggac ccttcaacgg actcgacaag ggggagcccg     2400

tcaacgcggc ggatgcagcg gccctcgagc acgacaaggc ctacgaccag cagctcaaag     2460

cgggtgacaa tccgtacctg cggtataacc acgccgacgc cgagtttcag gagcgtctgc     2520

aagaagatac gtcttttggg ggcaacctcg ggcgagcagt cttccaggcc aagaagaggg     2580

ttctcgaacc ttttggtctg gttgaggaag gtgctaagac ggctcctgga aagaaacgtc     2640

cggtagagca gtcgccacaa gagccagact cctcctcggg cattggcaag acaggccagc     2700

agcccgctaa aaagagactc aattttggtc agactggcga ctcagagtca gtccccgacc     2760

cacaacctct cggagaacct ccagcaaccc ccgctgctgt gggacctact acaatggctt     2820

caggcggtgg cgcaccaatg gcagacaata acgaaggcgc cgacggagtg ggtaatgcct     2880

caggaaattg gcattgcgat tccacatggc tgggcgacag agtcatcacc accagcaccc     2940

gaacatgggc cttgcccacc tataacaacc acctctacaa gcaaatctcc agtgcttcaa     3000

cgggggccag caacgacaac cactacttcg gctacagcac cccctggggg tattttgatt     3060

tcaacagatt ccactgccat ttctcaccac gtgactggca gcgactcatc aacaacaatt     3120

ggggattccg gcccaagaga ctcaacttca agctcttcaa catccaagtc aaggaggtca     3180

cgacgaatga tggcgtcacg accatcgcta ataaccttac cagcacggtt caagtcttct     3240

cggactcgga gtaccagttg ccgtacgtcc tcggctctgc gcaccagggc tgcctccctc     3300

cgttcccggc ggacgtgttc atgattccgc agtacggcta cctaacgctc aacaatggca     3360

gccaggcagt gggacggtca tccttttact gcctggaata tttcccatcg cagatgctga     3420

gaacgggcaa taactttacc ttcagctaca ccttcgagga cgtgcctttc cacagcagct     3480

acgcgcacag ccagagcctg gaccggctga tgaatcctct catcgaccag tacctgtatt     3540

acctgaacag aactcagaat cagtccggaa gtgcccaaaa caaggacttg ctgtttagcc     3600

gggggtctcc agctggcatg tctgttcagc ccaaaaactg gctacctgga ccctgttacc     3660

ggcagcagcg cgtttctaaa acaaaaacag acaacaacaa cagcaacttt acctggactg     3720

gtgcttcaaa atataacctt aatgggcgtg aatctataat caaccctggc actgctatgg     3780

cctcacacaa agacgacaaa gacaagttct ttcccatgag cggtgtcatg atttttggaa     3840

aggagagcgc cggagcttca aacactgcat tggacaatgt catgatcaca gacgaagagg     3900

aaatcaaagc cactaacccc gtggccaccg aaagatttgg gactgtggca gtcaatctcc     3960

agagcagcag cacagaccct gcgaccggag atgtgcatgt tatgggagcc ttacctggaa     4020

tggtgtggca agacagagac gtatacctgc agggtcctat ttgggccaaa attcctcaca     4080

cggatggaca ctttcacccg tctcctctca tgggcggctt tggacttaag cacccgcctc     4140

ctcagatcct catcaaaaac acgcctgttc ctgcgaatcc tccggcagag ttttcggcta     4200

caaagtttgc ttcattcatc acccagtatt ccacaggaca agtgagcgtg gagattgaat     4260

gggagctgca gaaagaaaac agcaaacgct ggaatcccga agtgcagtat acatctaact     4320

atgcaaaatc tgccaacgtt gatttcactg tggacaacaa tggactttat actgagcctc     4380

gccccattgg cacccgttac ctcacccgtc ccctgtaatt gtgtgttaat caataaaccg     4440

gttaattcgt gtcagttgaa ctttggtctc atgtcgttat tatcttatct ggtcaccata     4500

gcaaccggtt acacattaac tgcttagttg cgcttcgcga atacccctag tgatggagtt     4560

gcccactccc tctatgcgcg ctcgctcgct cggtggggcc ggcagagcag agctctgccg     4620

tctgcggacc tttggtccgc aggccccacc gagcgagcga gcgcgcatag agggagtggg     4680

caa                                                                   4683


<210>  28
<211>  736
<212>  PRT
<213>  adeno-associated virus 6

<400>  28

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Phe Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Ile Gly 
145                 150                 155                 160 


Lys Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Thr Pro Ala Ala Val Gly Pro Thr Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Ala Ser Thr Gly Ala Ser Asn Asp Asn His 
            260                 265                 270         


Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe 
        275                 280                 285             


His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn 
    290                 295                 300                 


Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln 
305                 310                 315                 320 


Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn 
                325                 330                 335     


Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro 
            340                 345                 350         


Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala 
        355                 360                 365             


Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly 
    370                 375                 380                 


Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro 
385                 390                 395                 400 


Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe 
                405                 410                 415     


Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp 
            420                 425                 430         


Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg 
        435                 440                 445             


Thr Gln Asn Gln Ser Gly Ser Ala Gln Asn Lys Asp Leu Leu Phe Ser 
    450                 455                 460                 


Arg Gly Ser Pro Ala Gly Met Ser Val Gln Pro Lys Asn Trp Leu Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Lys Thr Asp Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Thr Trp Thr Gly Ala Ser Lys Tyr Asn Leu Asn 
            500                 505                 510         


Gly Arg Glu Ser Ile Ile Asn Pro Gly Thr Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Lys Asp Lys Phe Phe Pro Met Ser Gly Val Met Ile Phe Gly 
    530                 535                 540                 


Lys Glu Ser Ala Gly Ala Ser Asn Thr Ala Leu Asp Asn Val Met Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Lys Ala Thr Asn Pro Val Ala Thr Glu Arg 
                565                 570                 575     


Phe Gly Thr Val Ala Val Asn Leu Gln Ser Ser Ser Thr Asp Pro Ala 
            580                 585                 590         


Thr Gly Asp Val His Val Met Gly Ala Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asn Pro Pro Ala Glu Phe Ser Ala Thr Lys Phe Ala Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Val Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Ala Lys Ser Ala Asn Val Asp Phe Thr Val Asp Asn Asn Gly Leu 
705                 710                 715                 720 


Tyr Thr Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu 
                725                 730                 735     


<210>  29
<211>  145
<212>  DNA
<213>  adeno-associated virus 2

<400>  29
ttggccactc cctctctgcg cgctcgctcg ctcactgagg ccgggcgacc aaaggtcgcc       60

cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc gagcgcgcag agagggagtg      120

gccaactcca tcactagggg ttcct                                            145


<210>  30
<211>  167
<212>  DNA
<213>  adeno-associated virus 2

<400>  30
ctctcccccc tgtcgcgttc gctcgctcgc tggctcgttt gggggggtgg cagctcaaag       60

agctgccaga cgacggccct ctggccgtcg cccccccaaa cgagccagcg agcgagcgaa      120

cgcgacaggg gggagagtgc cacactctca agcaaggggg ttttgta                    167


<210>  31
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  31
tccagaggtt cagtgctttg t                                                 21


<210>  32
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  32
atccagattg ccaaggtgag t                                                 21


<210>  33
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  33
attcctggct ctaccttgtg                                                   20


<210>  34
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  34
acacagacta cacccagaga                                                   20


<210>  35
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  35
gtaccgtttc agctcatcca                                                   20


<210>  36
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  36
ggttctgaca cagactacac cc                                                22


<210>  37
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  37
tagcttctgt acagctcgcc t                                                 21


<210>  38
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  38
ctgatctaga ggtaccggat cctttttttt tttt                                   34


<210>  39
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  39
cttgtgggag agtggttcag                                                   20


<210>  40
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  40
gtgttcaggg gctgtagaag t                                                 21


<210>  41
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  41
gctccaaggt cctcatgtcc                                                   20


<210>  42
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  42
tggcagaacc gttcactgta                                                   20


<210>  43
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  43
tggttggaac gaatgcctcc                                                   20


<210>  44
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  44
agtgtggatg agctgaaacg                                                   20


<210>  45
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  45
acaggctggc tccatttact                                                   20


<210>  46
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5' Hexachlorofluorescein (HEX)

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  3' Iowa Black(R) FQ quencher (IABKFQ)

<400>  46
tagcggctcc gaacccgaaa                                                   20


<210>  47
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  47
tgaggtaaag ttcttgaagc tcag                                              24


<210>  48
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  48
cttcttcagg gtcacttagc c                                                 21


<210>  49
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5' 6-Carboxyl-X-Rhodamine (ROX)

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  3' Iowa Black(R) FQ quencher (IABKFQ)

<400>  49
caatcagttt cagggacttc ctgaagc                                           27


<210>  50
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  50
tccctgaaga gttcctccac                                                   20


<210>  51
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  51
acttctctcg tcgctaccgt                                                   20


<210>  52
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5' 6-fluorescein amidite (6-FAM)

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  3' Iowa Black(R) FQ quencher (IABKFQ)

<400>  52
tcagctgcac ctgacgccct                                                   20


<210>  53
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  53
ggaaccccta gtgatggagt t                                                 21


<210>  54
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  54
cggcctcagt gagcg                                                        15


<210>  55
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5' 6-fluorescein amidite (6-FAM)

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  3' Iowa Black(R) FQ quencher (IABKFQ)

<400>  55
cactccctct ctgcgcgctc g                                                 21


<210>  56
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  56
gccagaaggt agcagagacc c                                                 21


<210>  57
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5' 6-fluorescein amidite (6-FAM)

<400>  57
ttgggtggag tcacatttct c                                                 21


<210>  58
<211>  886
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR product

<400>  58
ggttctgaca cagactacac ccagagaaag aagagcaagc accatgttga aactattatt       60

gtcacctaga tccttcttag tccttcagct gctcctgctg agggcagggt ggagctccaa      120

ggtcctcatg tccagtgcga atgaagacat caaagctggt aggaaaccta ggaccagagg      180

gagttgttga gaggaaggct atggggaaag ggcctgctag tgctcactat aatgactaaa      240

acgaagtgtg cagaggggga ggggaaggct ctctgcctca ctgctgcttc ttctgaccaa      300

gaattctttt tctttcactc cactatttca ttttcttccc aaacttagat ttgatcctga      360

cttctacagc ccctgaacac ctcagtgctc ctactctgcc ccttccagag gttcagtgct      420

ttgtgttcaa catagagtac atgaattgca cttggaatag cagttctgag cctcaggcaa      480

ccaacctcac gctgcactat aggtatgaga agggggaggg tagcacggga agaagaaaag      540

ggaggttagc tgggagagac tgcttgagga cccaatcaag tgggtagcca gctcttcagg      600

aaccctacca gtttctcatg ggatgcattg tcagttcaga ccagatgagg ctagctaatg      660

ggcatatgca tgcccatgtt tggcccatca ttcttttgcc ttgtaaccct tctctaggta      720

caaggtatct gataataata cattccagga gtgcagtcac tatttgttct ccaaagagat      780

tacttctggc tgtcagatac aaaaagaaga tatccagctc taccagacat ttgttgtcca      840

gctccaggac ccccagaaac cccagaggcg agctgtacag aagcta                     886


<210>  59
<211>  1173
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR product

<400>  59
cttgtgggag agtggttcag ggttctgaca cagactacac ccagagaaag aagagcaagc       60

accatgttga aactattatt gtcacctaga tccttcttag tccttcagct gctcctgctg      120

agggcagggt ggagctccaa ggtcctcatg tccagtgcga atgaagacat caaagctgat      180

ttgatcctga cttctacagc ccctgaacac ctcagtgctc ctactctgcc ccttccagag      240

gttcagtgct ttgtgttcaa catagagtac atgaattgca cttggaatag cagttctgag      300

cctcaggcaa ccaacctcac gctgcactat aggtacaagg tatctgataa taatacattc      360

caggagtgca gtcactattt gttctccaaa gagattactt ctggctgtca gatacaaaaa      420

gaagatatcc agctctacca gacatttgtt gtccagctcc aggaccccca gaaaccccag      480

aggcgagctg tacagaagct aaacctacag aatcttgtga tcccacgggc tccagaaaat      540

ctaacactca gcaatctgag tgaatcccag ctagagctga gatggaaaag cagacatatt      600

aaagaacgct gtttacaata cttggtgcag taccggagca acagagatcg aagctggacg      660

gaactaatag tgaatcatga acctagattc tccctgccta gtgtggatga gctgaaacgg      720

tacacatttc gggttcggag ccgctataac ccaatctgtg gaagttctca acagtggagt      780

aaatggagcc agcctgtcca ctgggggagt catactgtag aggagaatcc ttccttgttt      840

gcactggaag ctgtgcttat ccctgttggc accatggggt tgattattac cctgatcttt      900

gtgtactgtt ggttggaacg aatgcctcca attcccccca tcaagaatct agaggatctg      960

gttactgaat accaagggaa cttttcggcc tggagtggtg tgtctaaagg gctgactgag     1020

agtctgcagc cagactacag tgaacggttc tgccacgtca gcgagattcc ccccaaagga     1080

ggggccctag gagaggggcc tggaggttct ccttgcagcc tgcatagccc ttactggcct     1140

cccccatgtt attctctgaa gccggaagcc tga                                  1173


<210>  60
<211>  1173
<212>  DNA
<213>  Mus musculus

<400>  60
cttgtgggag agtggttcag ggttctgaca cagactacac ccagagaaag aagagcaagc       60

accatgttga aactattatt gtcacctaga tccttcttag tccttcagct gctcctgctg      120

agggcagggt ggagctccaa ggtcctcatg tccagtgcga atgaagacat caaagctgat      180

ttgatcctga cttctacagc ccctgaacac ctcagtgctc ctactctgcc ccttccagag      240

gttcagtgct ttgtgttcaa catagagtac atgaattgca cttggaatag cagttctgag      300

cctcaggcaa ccaacctcac gctgcactat aggtacaagg tatctgataa taatacattc      360

caggagtgca gtcactattt gttctccaaa gagattactt ctggctgtca gatacaaaaa      420

gaagatatcc agctctacca gacatttgtt gtccagctcc aggaccccca gaaaccccag      480

aggcgagctg tacagaagct aaacctacag aatcttgtga tcccacgggc tccagaaaat      540

ctaacactca gcaatctgag tgaatcccag ctagagctga gatggaaaag cagacatatt      600

aaagaacgct gtttacaata cttggtgcag taccggagca acagagatcg aagctggacg      660

gaactaatag tgaatcatga acctagattc tccctgccta gtgtggatga gctgaaacgg      720

tacacatttc gggttcggag ccgctataac ccaatctgtg gaagttctca acagtggagt      780

aaatggagcc agcctgtcca ctgggggagt catactgtag aggagaatcc ttccttgttt      840

gcactggaag ctgtgcttat ccctgttggc accatggggt tgattattac cctgatcttt      900

gtgtactgtt ggttggaacg aatgcctcca attcccccca tcaagaatct agaggatctg      960

gttactgaat accaagggaa cttttcggcc tggagtggtg tgtctaaagg gctgactgag     1020

agtctgcagc cagactacag tgaacggttc tgccacgtca gcgagattcc ccccaaagga     1080

ggggccctag gagaggggcc tggaggttct ccttgcagcc tgcatagccc ttactggcct     1140

cccccatgtt attctctgaa gccggaagcc tga                                  1173


<210>  61
<211>  7013
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pAAV-mIl2rgEx3-8pA plasmid

<400>  61
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc       60

gggcgacctt tggtcgcccg gcctcagtga gcgagcgagc gcgcagagag ggagtggcca      120

actccatcac taggggttcc tgcggccgct tgaaactatt attgtcacct agatccttct      180

tagtccttca gctgctcctg ctgagggcag ggtggagctc caaggtcctc atgtccagtg      240

cgaatgaaga catcaaagct ggtaggaaac ctaggaccag agggagttgt tgagaggaag      300

gctatgggga aagggcctgc tagtgctcac tataatgact aaaacgaagt gtgcagaggg      360

ggaggggaag gctctctgcc tcactgctgc ttcttctgac caagaattct ttttctttca      420

ctccactatt tcattttctt cccaaactta gatttgatcc tgacttctac agcccctgaa      480

cacctcagtg ctcctactct gccccttcca gaggttcagt gctttgtgtt caacatagag      540

tacatgaatt gcacttggaa tagcagttct gagcctcagg caaccaacct cacgctgcac      600

tataggtatg agaaggggga gggtagcacg ggaagaagaa aagggaggtt agctgggaga      660

gactgcttga ggacccaatc aagtgggtag ccagctcttc aggaacccta ccagtttctc      720

atgggatgca ttgtcagttc agaccagatg aggctagcta atgggcatat gcatgcccat      780

gtttggccca tcattctttt gccttgtaac ccttctctag gtacaaggta tctgataata      840

atacattcca ggagtgcagt cactatttgt tctccaaaga gattacttct ggctgtcaga      900

tacaaaaaga agatatccag ctctaccaga catttgttgt ccagctccag gacccccaga      960

aaccccagag gcgagctgta cagaagctaa acctacagaa tcttgtgatc ccacgggctc     1020

cagaaaatct aacactcagc aatctgagtg aatcccagct agagctgaga tggaaaagca     1080

gacatattaa agaacgctgt ttacaatact tggtgcagta ccggagcaac agagatcgaa     1140

gctggacgga actaatagtg aatcatgaac ctagattctc cctgcctagt gtggatgagc     1200

tgaaacggta cacatttcgg gttcggagcc gctataaccc aatctgtgga agttctcaac     1260

agtggagtaa atggagccag cctgtccact gggggagtca tactgtagag gagaatcctt     1320

ccttgtttgc actggaagct gtgcttatcc ctgttggcac catggggttg attattaccc     1380

tgatctttgt gtactgttgg ttggaacgaa tgcctccaat tccccccatc aagaatctag     1440

aggatctggt tactgaatac caagggaact tttcggcctg gagtggtgtg tctaaagggc     1500

tgactgagag tctgcagcca gactacagtg aacggttctg ccacgtcagc gagattcccc     1560

ccaaaggagg ggccctagga gaggggcctg gaggttctcc ttgcagcctg catagccctt     1620

actggcctcc cccatgttat tctctgaagc cggaagcctg aaataaaaga tccttatttt     1680

cattggatct gtgtgttggt tttttgtgtg cttatcgata ccgtcgacct cgagggcccc     1740

tgcaggtcaa ttctaccggg taggggaggc gcttttccca aggcagtctg gagcatgcgc     1800

tttagcagcc ccgctgggca cttggcgcta cacaagtggc ctctggcctc gcacacattc     1860

cacatccacc ggtaggcgcc aaccggctcc gttctttggt ggccccttcg cgccaccttc     1920

tactcctccc ctagtcagga agttcccccc cgccccgcag ctcgcgtcgt gcaggacgtg     1980

acaaatggaa gtagcacgtc tcactagtct cgtgcagatg gacagcaccg ctgagcaatg     2040

gaagcgggta ggcctttggg gcagcggcca atagcagctt tgctccttcg ctttctgggc     2100

tcagaggctg ggaaggggtg ggtccggggg cgggctcagg ggcgggctca ggggcggggc     2160

gggcgcccga aggtcctccg gaggcccggc attctgcacg cttcaaaagc gcacgtctgc     2220

cgcgctgttc tcctcttcct catctccggg cctttcgacc tgcagccaat atgggatcgg     2280

ccattgaaca agatggattg cacgcaggtt ctccggccgc ttgggtggag aggctattcg     2340

gctatgactg ggcacaacag acaatcggct gctctgatgc cgccgtgttc cggctgtcag     2400

cgcaggggcg cccggttctt tttgtcaaga ccgacctgtc cggtgccctg aatgaactgc     2460

aggacgaggc agcgcggcta tcgtggctgg ccacgacggg cgttccttgc gcagctgtgc     2520

tcgacgttgt cactgaagcg ggaagggact ggctgctatt gggcgaagtg ccggggcagg     2580

atctcctgtc atctcacctt gctcctgccg agaaagtatc catcatggct gatgcaatgc     2640

ggcggctgca tacgcttgat ccggctacct gcccattcga ccaccaagcg aaacatcgca     2700

tcgagcgagc acgtactcgg atggaagccg gtcttgtcga tcaggatgat ctggacgaag     2760

agcatcaggg gctcgcgcca gccgaactgt tcgccaggct caaggcgcgc atgcccgacg     2820

gcgatgatct cgtcgtgacc catggcgatg cctgcttgcc gaatatcatg gtggaaaatg     2880

gccgcttttc tggattcatc gactgtggcc ggctgggtgt ggcggaccgc tatcaggaca     2940

tagcgttggc tacccgtgat attgctgaag agcttggcgg cgaatgggct gaccgcttcc     3000

tcgtgcttta cggtatcgcc gctcccgatt cgcagcgcat cgccttctat cgccttcttg     3060

acgagttctt ctgaggggat cgatccgctg taagtctgca gaaattgatg atctattaaa     3120

caataaagat gtccactaaa atggaagttt ttcctgtcat actttgttaa gaagggtgag     3180

aacagagtac ctacattttg aatggaagga ttggagctac gggggtgggg gtggggtggg     3240

attagataaa tgcctgctct ttactgaagg ctctttacta ttgctttatg ataatgtttc     3300

atagttggat atcataattt aaacaagcaa aaccaaatta agggccagct cattcctccc     3360

actcatgatc tatagatcta tagatctctc gtgggatcat tgtttttctc ttgattccca     3420

ctttgtggtt ctaagtactg tggtttccaa atgtgtcagt ttcatagcct gaagaacgag     3480

atcagcagcc tctgttccac atacacttca ttctcagtat tgttttgcca agttctaatt     3540

ccatcagaag ctgactctag aggatccaat gctcactgcc ttcccttggg gctaagtttc     3600

gatttcctgt cccatgtaac tgcttttctg ttccatatgc cctacttgag agtgtccctt     3660

gccctctttc cctgcacaag ccctcccatg cccagcctaa cacctttcca ctttctttga     3720

agagagtctt accctgtagc ccagggtggc tgggagctca ctatgtaggc caggttggcc     3780

tccaactcac aggctatcct cccacctctg cctcataaga gttggggtta ctggcatgca     3840

ccaccacacc cagcatggtc cttctctttt ataggattct ccctcccttt ttctacctat     3900

gattcaactg tttccaaatc aacaagaaat aaagttttta accaatgatc atcaagaatg     3960

tctgttacag gggttgggga gcaggggaaa tatggcgaac aatgaagttg ggaggaatgg     4020

ggtgagggta ggccaaaggg gtgggatagt catactgagg aaggaagagg accacagatt     4080

agctgaaagg agtactgttt tggctactta ctattctctg gtaaatttct gggctcactc     4140

caggggtcag tttagagtta tctttgccat gttggcccaa ttcctcgaag ctcctttaca     4200

gatcccatcc agtgtcttct ctccctggcc ttactctgcc ttctattgca cataacactt     4260

ctgacctgcg gccgcaggaa cccctagtga tggagttggc cactccctct ctgcgcgctc     4320

gctcgctcac tgaggccggg cgaccaaagg tcgcccgacg cccgggcttt gcccgggcgg     4380

cctcagtgag cgagcgagcg cgcagctgcc tgcaggggcg cctgatgcgg tattttctcc     4440

ttacgcatct gtgcggtatt tcacaccgca tacgtcaaag caaccatagt acgcgccctg     4500

tagcggcgca ttaagcgcgg cgggtgtggt ggttacgcgc agcgtgaccg ctacacttgc     4560

cagcgcccta gcgcccgctc ctttcgcttt cttcccttcc tttctcgcca cgttcgccgg     4620

ctttccccgt caagctctaa atcgggggct ccctttaggg ttccgattta gtgctttacg     4680

gcacctcgac cccaaaaaac ttgatttggg tgatggttca cgtagtgggc catcgccctg     4740

atagacggtt tttcgccctt tgacgttgga gtccacgttc tttaatagtg gactcttgtt     4800

ccaaactgga acaacactca accctatctc gggctattct tttgatttat aagggatttt     4860

gccgatttcg gcctattggt taaaaaatga gctgatttaa caaaaattta acgcgaattt     4920

taacaaaata ttaacgttta caattttatg gtgcactctc agtacaatct gctctgatgc     4980

cgcatagtta agccagcccc gacacccgcc aacacccgct gacgcgccct gacgggcttg     5040

tctgctcccg gcatccgctt acagacaagc tgtgaccgtc tccgggagct gcatgtgtca     5100

gaggttttca ccgtcatcac cgaaacgcgc gagacgaaag ggcctcgtga tacgcctatt     5160

tttataggtt aatgtcatga taataatggt ttcttagacg tcaggtggca cttttcgggg     5220

aaatgtgcgc ggaaccccta tttgtttatt tttctaaata cattcaaata tgtatccgct     5280

catgagacaa taaccctgat aaatgcttca ataatattga aaaaggaaga gtatgagtat     5340

tcaacatttc cgtgtcgccc ttattccctt ttttgcggca ttttgccttc ctgtttttgc     5400

tcacccagaa acgctggtga aagtaaaaga tgctgaagat cagttgggtg cacgagtggg     5460

ttacatcgaa ctggatctca acagcggtaa gatccttgag agttttcgcc ccgaagaacg     5520

ttttccaatg atgagcactt ttaaagttct gctatgtggc gcggtattat cccgtattga     5580

cgccgggcaa gagcaactcg gtcgccgcat acactattct cagaatgact tggttgagta     5640

ctcaccagtc acagaaaagc atcttacgga tggcatgaca gtaagagaat tatgcagtgc     5700

tgccataacc atgagtgata acactgcggc caacttactt ctgacaacga tcggaggacc     5760

gaaggagcta accgcttttt tgcacaacat gggggatcat gtaactcgcc ttgatcgttg     5820

ggaaccggag ctgaatgaag ccataccaaa cgacgagcgt gacaccacga tgcctgtagc     5880

aatggcaaca acgttgcgca aactattaac tggcgaacta cttactctag cttcccggca     5940

acaattaata gactggatgg aggcggataa agttgcagga ccacttctgc gctcggccct     6000

tccggctggc tggtttattg ctgataaatc tggagccggt gagcgtgggt ctcgcggtat     6060

cattgcagca ctggggccag atggtaagcc ctcccgtatc gtagttatct acacgacggg     6120

gagtcaggca actatggatg aacgaaatag acagatcgct gagataggtg cctcactgat     6180

taagcattgg taactgtcag accaagttta ctcatatata ctttagattg atttaaaact     6240

tcatttttaa tttaaaagga tctaggtgaa gatccttttt gataatctca tgaccaaaat     6300

cccttaacgt gagttttcgt tccactgagc gtcagacccc gtagaaaaga tcaaaggatc     6360

ttcttgagat cctttttttc tgcgcgtaat ctgctgcttg caaacaaaaa aaccaccgct     6420

accagcggtg gtttgtttgc cggatcaaga gctaccaact ctttttccga aggtaactgg     6480

cttcagcaga gcgcagatac caaatactgt ccttctagtg tagccgtagt taggccacca     6540

cttcaagaac tctgtagcac cgcctacata cctcgctctg ctaatcctgt taccagtggc     6600

tgctgccagt ggcgataagt cgtgtcttac cgggttggac tcaagacgat agttaccgga     6660

taaggcgcag cggtcgggct gaacgggggg ttcgtgcaca cagcccagct tggagcgaac     6720

gacctacacc gaactgagat acctacagcg tgagctatga gaaagcgcca cgcttcccga     6780

agggagaaag gcggacaggt atccggtaag cggcagggtc ggaacaggag agcgcacgag     6840

ggagcttcca gggggaaacg cctggtatct ttatagtcct gtcgggtttc gccacctctg     6900

acttgagcgt cgatttttgt gatgctcgtc aggggggcgg agcctatgga aaaacgccag     6960

caacgcggcc tttttacggt tcctggcctt ttgctggcct tttgctcaca tgt            7013


