                         SEQUENCE LISTING

<110>  ASCLEPIX THERAPEUTICS, LLC
       BRESSLER, ERIC
       GREEN, JORDAN
       PANDEY, NIRANJAN
       POPEL, ALEKSANDER
       SHMUELI, RON
 
<120>  PEPTIDES WITH ANTI-ANGIOGENIC, ANTI-LYMPHANGIOGENIC, AND 
       ANTI-EDEMIC PROPERTIES AND NANOPARTICLE FORMULATIONS

<130>  ASX-001PC

<140>  PCT/US16/62816
<141>  2016-11-18

<150>  62/257,569
<151>  2015-11-19

<160>  31    

<170>  PatentIn version 3.5

<210>  1
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC PEPTIDE


<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa can be any naturally occurring amino acid or non-genetically encoded amin acid

<220>
<221>  misc_feature
<222>  (9)..(12)
<223>  Xaa can be any naturally occurring amino acid or non-genetically encoded amin acid

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Xaa can be any naturally occurring amino acid or non-genetically encoded amin acid

<400>  1

Leu Arg Arg Phe Ser Thr Xaa Pro Xaa Xaa Xaa Xaa Asn Ile Asn Asn 
1               5                   10                  15      


Val Xaa Asn Phe 
            20  


<210>  2
<211>  20
<212>  PRT
<213>  Artifical Sequence

<400>  2

Leu Arg Arg Phe Ser Thr Ala Pro Phe Ala Phe Ile Asp Ile Asn Asp 
1               5                   10                  15      


Val Ile Asn Phe 
            20  


<210>  3
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC PEPTIDE

<400>  3

Leu Arg Arg Phe Ser Thr Ala Pro Phe Ala Phe Ile Asn Ile Asn Asn 
1               5                   10                  15      


Val Ile Asn Phe 
            20  


<210>  4
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC PEPTIDE

<400>  4

Leu Arg Arg Phe Ser Thr Ala Pro Phe Ala Phe Ile Asp Ile Asn Asp 
1               5                   10                  15      


Val Ile Asn Trp 
            20  


<210>  5
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC PEPTIDE

<400>  5

Phe Thr Asn Ile Asn Asn Val Thr Asn 
1               5                   


<210>  6
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC PEPTIDE

<400>  6

Phe Thr Asp Ile Asn Asp Val Thr Asn 
1               5                   


<210>  7
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC PEPTIDE


<220>
<221>  Non-genetically encoded amin acid
<222>  (12)..(12)
<223>  Abu (2-Aminobutyric acid)

<220>
<221>  Non-genetically encoded amin acid
<222>  (18)..(18)
<223>  Abu (2-Aminobutyric acid)

<400>  7

Leu Arg Arg Phe Ser Thr Met Pro Phe Met Phe Xaa Asn Ile Asn Asn 
1               5                   10                  15      


Val Xaa Asn Phe 
            20  


<210>  8
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC PEPTIDE


<220>
<221>  Non-Genetically encoded amin acid
<222>  (12)..(12)
<223>  Abu (2-Aminobutyric acid)

<220>
<221>  Non-Genetically encoded amin acid
<222>  (18)..(18)
<223>  Abu (2-Aminobutyric acid)

<400>  8

Leu Arg Arg Phe Ser Thr Met Pro Ala Met Phe Xaa Asn Ile Asn Asn 
1               5                   10                  15      


Val Xaa Asn Phe 
            20  


<210>  9
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC PEPTIDE


<220>
<221>  Non-Genetically encoded amin acid
<222>  (12)..(12)
<223>  Abu (2-Aminobutyric acid)

<220>
<221>  Non-Genetically encoded amin acid
<222>  (18)..(18)
<223>  Abu (2-Aminobutyric acid)

<400>  9

Leu Arg Arg Phe Ser Thr Met Pro Phe Ala Phe Xaa Asn Ile Asn Asn 
1               5                   10                  15      


Val Xaa Asn Phe 
            20  


<210>  10
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC PEPTIDE


<220>
<221>  Non-Genetically encoded amin acid
<222>  (12)..(12)
<223>  Abu (2-Aminobutyric acid)

<220>
<221>  Non-Genetically encoded amin acid
<222>  (18)..(18)
<223>  Abu (2-Aminobutyric acid)

<400>  10

Leu Arg Arg Phe Ser Thr Met Pro Phe Met Ala Xaa Asn Ile Asn Asn 
1               5                   10                  15      


Val Xaa Asn Phe 
            20  


<210>  11
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC PEPTIDE


<220>
<221>  Non-Genetically encoded amin acid
<222>  (10)..(10)
<223>  Nle (norleucine)

<220>
<221>  Non-Genetically encoded amin acid
<222>  (12)..(12)
<223>  Abu (2-Aminobutyric acid)

<220>
<221>  Non-Genetically encoded amin acid
<222>  (18)..(18)
<223>  Abu (2-Aminobutyric acid)

<400>  11

Leu Arg Arg Phe Ser Thr Met Pro Phe Xaa Phe Xaa Asn Ile Asn Asn 
1               5                   10                  15      


Val Xaa Asn Phe 
            20  


<210>  12
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC PEPTIDE


<220>
<221>  Non-Genetically encoded amin acid
<222>  (11)..(11)
<223>  4-ClPhe (4-chlorophenylalanine)

<220>
<221>  Non-Genetically encoded amin acid
<222>  (12)..(12)
<223>  Abu (2-Aminobutyric acid)

<220>
<221>  Non-Genetically encoded amin acid
<222>  (18)..(18)
<223>  Abu (2-Aminobutyric acid)

<400>  12

Leu Arg Arg Phe Ser Thr Met Pro Phe Met Xaa Xaa Asn Ile Asn Asn 
1               5                   10                  15      


Val Xaa Asn Phe 
            20  


<210>  13
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC PEPTIDE

<400>  13

Leu Arg Arg Phe Ser Thr Met Pro Phe Met Phe Ser Asn Ile Asn Asn 
1               5                   10                  15      


Val Ser Asn Phe 
            20  


<210>  14
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC PEPTIDE

<400>  14

Leu Arg Arg Phe Ser Thr Met Pro Phe Met Phe Ala Asn Ile Asn Asn 
1               5                   10                  15      


Val Ala Asn Phe 
            20  


<210>  15
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC PEPTIDE

<400>  15

Leu Arg Arg Phe Ser Thr Met Pro Phe Met Phe Ile Asn Ile Asn Asn 
1               5                   10                  15      


Val Ile Asn Phe 
            20  


<210>  16
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC PEPTIDE

<400>  16

Leu Arg Arg Phe Ser Thr Met Pro Phe Met Phe Thr Asn Ile Asn Asn 
1               5                   10                  15      


Val Thr Asn Phe 
            20  


<210>  17
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC PEPTIDE


<220>
<221>  Non-Genetically encoded amin acid
<222>  (12)..(12)
<223>  AllylGly (Allylglycine)

<220>
<221>  Non-Genetically encoded amin acid
<222>  (18)..(18)
<223>  AllylGly (Allylglycine)

<400>  17

Leu Arg Arg Phe Ser Thr Met Pro Phe Met Phe Xaa Asn Ile Asn Asn 
1               5                   10                  15      


Val Xaa Asn Phe 
            20  


<210>  18
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC PEPTIDE

<400>  18

Leu Arg Arg Phe Ser Thr Met Pro Phe Met Phe Val Asn Ile Asn Asn 
1               5                   10                  15      


Val Val Asn Phe 
            20  


<210>  19
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC PEPTIDE


<220>
<221>  Non-Genetically encoded amin acid
<222>  (10)..(10)
<223>  d Alanine

<400>  19

Leu Arg Arg Phe Ser Thr Met Pro Phe Xaa Phe Ile Asn Ile Asn Asn 
1               5                   10                  15      


Val Ile Asn Phe 
            20  


<210>  20
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC PEPTIDE

<400>  20

Leu Arg Arg Phe Ser Thr Met Pro Phe Ala Phe Ile Asn Ile Asn Asn 
1               5                   10                  15      


Val Ile Asn Phe 
            20  


<210>  21
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC PEPTIDE

<400>  21

Leu Arg Arg Phe Ser Thr Ala Pro Phe Ala Phe Ile Asn Ile Asn Asn 
1               5                   10                  15      


Val Ile Asn Phe 
            20  


<210>  22
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC PEPTIDE


<220>
<221>  Non-Genetically encoded amin acid
<222>  (10)..(10)
<223>  d Alanine

<400>  22

Leu Arg Arg Phe Ser Thr Ala Pro Phe Xaa Phe Ile Asp Ile Asn Asp 
1               5                   10                  15      


Val Ile Asn Phe 
            20  


<210>  23
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC PEPTIDE


<220>
<221>  Non_Genetically encoded amin acid
<222>  (2)..(2)
<223>  Abu (2-Aminobutyric acid)

<220>
<221>  Non_Genetically encoded amin acid
<222>  (8)..(8)
<223>  Abu (2-Aminobutyric acid)

<400>  23

Phe Xaa Asn Ile Asn Asn Val Xaa Asn 
1               5                   


<210>  24
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC PEPTIDE

<400>  24

Phe Thr Asn Ile Asn Asn Val Thr Asn 
1               5                   


<210>  25
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC PEPTIDE

<400>  25

Phe Ile Asn Ile Asn Asn Val Ile Asn Phe 
1               5                   10  


<210>  26
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC PEPTIDE

<400>  26

Phe Ser Asn Ile Asn Asn Val Ser Asn Phe 
1               5                   10  


<210>  27
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC PEPTIDE

<400>  27

Phe Ala Asn Ile Asn Asn Val Ala Asn Phe 
1               5                   10  


<210>  28
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC PEPTIDE


<220>
<221>  Non-Genetically encoded amin acid
<222>  (2)..(2)
<223>  AllylGly (Allylglycine)

<220>
<221>  Non-Genetically encoded amin acid
<222>  (8)..(8)
<223>  AllylGly (Allylglycine)

<400>  28

Phe Xaa Asn Ile Asn Asn Val Xaa Asn Phe 
1               5                   10  


<210>  29
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC PEPTIDE

<400>  29

Phe Val Asn Ile Asn Asn Val Val Asn Phe 
1               5                   10  


<210>  30
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC PEPTIDE


<220>
<221>  Non-Genetically encoded amin acid
<222>  (2)..(2)
<223>  Abu (2-Aminobutyric acid)

<220>
<221>  Non-Genetically encoded amin acid
<222>  (8)..(8)
<223>  Abu (2-Aminobutyric acid)

<400>  30

Ala Xaa Asn Ile Asn Asn Val Xaa Asn Phe 
1               5                   10  


<210>  31
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC PEPTIDE


<220>
<221>  Non-Genetically encoded amin acid
<222>  (1)..(1)
<223>  4-ClPhe (4-chlorophenylalanine)

<220>
<221>  Non-Genetically encoded amin acid
<222>  (2)..(2)
<223>  Abu (2-Aminobutyric acid )

<220>
<221>  Non-Genetically encoded amin acid
<222>  (8)..(8)
<223>  Abu (2-Aminobutyric acid )

<400>  31

Xaa Xaa Asn Ile Asn Asn Val Xaa Asn Phe 
1               5                   10  


