                         SEQUENCE LISTING

<110>  REVITOPE LIMITED
       Cobbold, Mark
 
<120>  FUNCTIONAL ANTIBODY FRAGMENT COMPLEMENTATION FOR A TWO-COMPONENTS
        SYSTEM FOR REDIRECTED KILLING OF UNWANTED CELLS

<130>  01131-0007-00PCT

<140>  PCT/US2016/062748
<141>  2016-11-18

<150>  US62/257,552
<151>  2015-11-19

<150>  US62/270,907
<151>  2015-12-22

<160>  177   

<170>  PatentIn version 3.5

<210>  1
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADAM28 cleavage site

<400>  1

Lys Pro Ala Lys Phe Phe Arg Leu 
1               5               


<210>  2
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADAM28 cleavage site

<400>  2

Asp Pro Ala Lys Phe Phe Arg Leu 
1               5               


<210>  3
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADAM28 cleavage site

<400>  3

Lys Pro Met Lys Phe Phe Arg Leu 
1               5               


<210>  4
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADAM28 cleavage site

<400>  4

Leu Pro Ala Lys Phe Phe Arg Leu 
1               5               


<210>  5
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADAM28 cleavage site

<400>  5

Leu Pro Met Lys Phe Phe Arg Leu 
1               5               


<210>  6
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADAM28 cleavage site

<400>  6

Lys Pro Ala Met Phe Phe Arg Leu 
1               5               


<210>  7
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADAM28 cleavage site

<400>  7

Tyr Pro Ala Lys Phe Phe Arg Leu 
1               5               


<210>  8
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADAM28 cleavage site

<400>  8

Lys Trp Ala Lys Phe Phe Arg Leu 
1               5               


<210>  9
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADAM28 cleavage site

<400>  9

Asp Pro Met Lys Phe Phe Arg Leu 
1               5               


<210>  10
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADAM28 cleavage site

<400>  10

Asp Pro Ala Met Phe Phe Arg Leu 
1               5               


<210>  11
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADAM28 cleavage site

<400>  11

Asp Pro Met Met Phe Phe Arg Leu 
1               5               


<210>  12
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADAM28 cleavage site

<400>  12

Lys Met Ala Met Phe Phe Arg Leu 
1               5               


<210>  13
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADAM28 cleavage site

<400>  13

Lys Met Ala Met Phe Phe Ile Met 
1               5               


<210>  14
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADAM28 cleavage site

<400>  14

Lys Pro Ala Met Phe Phe Ile Met 
1               5               


<210>  15
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADAM28 cleavage site

<400>  15

Leu Pro Ala Met Phe Phe Arg Leu 
1               5               


<210>  16
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADAM28 cleavage site

<400>  16

Leu Pro Met Met Phe Phe Arg Leu 
1               5               


<210>  17
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADAM28 cleavage site

<400>  17

Leu Met Ala Met Phe Phe Arg Leu 
1               5               


<210>  18
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADAM28 cleavage site

<400>  18

Leu Met Ala Met Phe Phe Ile Met 
1               5               


<210>  19
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADAM28 cleavage site

<400>  19

Leu Pro Ala Met Phe Phe Ile Met 
1               5               


<210>  20
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADAM28 cleavage site

<400>  20

Leu Pro Ala Met Phe Phe Tyr Met 
1               5               


<210>  21
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADAM28 cleavage site

<400>  21

Lys Pro Met Met Phe Phe Arg Leu 
1               5               


<210>  22
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADAM28 cleavage site

<400>  22

Lys Pro Ala Lys Phe Phe Tyr Met 
1               5               


<210>  23
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADAM28 cleavage site

<400>  23

Lys Pro Ala Lys Phe Phe Ile Met 
1               5               


<210>  24
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADAM28 cleavage site

<400>  24

Ile Pro Met Lys Phe Phe Arg Leu 
1               5               


<210>  25
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADAM28 cleavage site

<400>  25

Ile Pro Ala Met Phe Phe Arg Leu 
1               5               


<210>  26
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADAM28 cleavage site

<400>  26

Ile Pro Met Met Phe Phe Arg Leu 
1               5               


<210>  27
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADAM28 cleavage site

<400>  27

Ile Met Ala Met Phe Phe Arg Leu 
1               5               


<210>  28
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADAM28 cleavage site

<400>  28

Ile Met Ala Met Phe Phe Ile Met 
1               5               


<210>  29
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADAM28 cleavage site

<400>  29

Ile Pro Ala Met Phe Phe Ile Met 
1               5               


<210>  30
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADAM28 cleavage site

<400>  30

Ile Pro Ala Met Phe Phe Tyr Met 
1               5               


<210>  31
<211>  2
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cathepsin B cleavage site

<400>  31

Phe Arg 
1       


<210>  32
<211>  2
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cathepsin B cleavage site

<400>  32

Phe Lys 
1       


<210>  33
<211>  2
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cathepsin B cleavage site

<400>  33

Val Ala 
1       


<210>  34
<211>  2
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cathepsin B cleavage site

<400>  34

Val Arg 
1       


<210>  35
<211>  2
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cathepsin B cleavage site


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  X = {Cit}

<400>  35

Val Xaa 
1       


<210>  36
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cathepsin B cleavage site

<400>  36

His Leu Val Glu Ala Leu Tyr Leu 
1               5               


<210>  37
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cathepsin B cleavage site

<400>  37

Ser Leu Leu Lys Ser Arg Met Val Pro Asn Phe Asn 
1               5                   10          


<210>  38
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cathepsin B cleavage site

<400>  38

Ser Leu Leu Ile Ala Arg Arg Met Pro Asn Phe Asn 
1               5                   10          


<210>  39
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cathepsin B cleavage site

<400>  39

Lys Lys Phe Ala 
1               


<210>  40
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cathepsin B cleavage site

<400>  40

Ala Phe Lys Lys 
1               


<210>  41
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cathepsin B cleavage site

<400>  41

Gln Gln Gln 
1           


<210>  42
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cathepsin D cleavage site

<400>  42

Pro Arg Ser Phe Phe Arg Leu Gly Lys 
1               5                   


<210>  43
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cathepsin D cleavage site

<400>  43

Ser Gly Val Val Ile Ala Thr Val Ile Val Ile Thr 
1               5                   10          


<210>  44
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cathepsin K cleavage site

<400>  44

Gly Gly Pro 
1           


<210>  45
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MMP1 cleavage site

<400>  45

Ser Leu Gly Pro Gln Gly Ile Trp Gly Gln Phe Asn 
1               5                   10          


<210>  46
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MMP2 cleavage site

<400>  46

Ala Ile Pro Val Ser Leu Arg 
1               5           


<210>  47
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MMP2 cleavage site

<400>  47

Ser Leu Pro Leu Gly Leu Trp Ala Pro Asn Phe Asn 
1               5                   10          


<210>  48
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MMP2 cleavage site

<400>  48

His Pro Val Gly Leu Leu Ala Arg 
1               5               


<210>  49
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MMP2 cleavage site

<400>  49

Gly Pro Leu Gly Val Arg Gly Lys 
1               5               


<210>  50
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MMP2 cleavage site

<400>  50

Gly Pro Leu Gly Leu Trp Ala Gln 
1               5               


<210>  51
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MMP3 cleavage site

<400>  51

Ser Thr Ala Val Ile Val Ser Ala 
1               5               


<210>  52
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MMP7 cleavage site

<400>  52

Gly Pro Leu Gly Leu Ala Arg Lys 
1               5               


<210>  53
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MMP7 cleavage site

<400>  53

Arg Pro Leu Ala Leu Trp Arg Ser 
1               5               


<210>  54
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MMP7 cleavage site

<400>  54

Ser Leu Arg Pro Leu Ala Leu Trp Arg Ser Phe Asn 
1               5                   10          


<210>  55
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MMP2/9 cleavage site

<400>  55

Gly Ile Leu Gly Val Pro 
1               5       


<210>  56
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MMP2/9 cleavage site

<400>  56

Gly Pro Leu Gly Ile Ala Gly Gln 
1               5               


<210>  57
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MMP9 cleavage site

<400>  57

Ala Val Arg Trp Leu Leu Thr Ala 
1               5               


<210>  58
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MMP9 cleavage site

<400>  58

Pro Leu Gly Leu Tyr Ala Leu 
1               5           


<210>  59
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MMP9 cleavage site

<400>  59

Gly Pro Gln Gly Ile Ala Gly Gln Arg 
1               5                   


<210>  60
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MMP9 cleavage site

<400>  60

Lys Pro Val Ser Leu Ser Tyr Arg 
1               5               


<210>  61
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MMP11 cleavage site

<400>  61

Ala Ala Ala Thr Ser Ile Ala Met 
1               5               


<210>  62
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MMP11 cleavage site

<400>  62

Ala Ala Gly Ala Met Phe Leu Glu 
1               5               


<210>  63
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MMP13 cleavage site

<400>  63

Gly Pro Gln Gly Leu Ala Gly Gln Arg Gly Ile Val 
1               5                   10          


<210>  64
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MMP14 cleavage site

<400>  64

Pro Arg His Leu Arg 
1               5   


<210>  65
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MMP14 cleavage site

<400>  65

Pro Gln Gly Leu Leu Gly Ala Pro Gly Ile Leu Gly 
1               5                   10          


<210>  66

<400>  66
000

<210>  67
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PSA / KLK3

<400>  67

His Ser Ser Lys Leu Gln 
1               5       


<210>  68
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PSA / KLK3

<400>  68

Ser Ser Lys Leu Gln 
1               5   


<210>  69
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KLK4

<400>  69

Arg Gln Gln Arg 
1               


<210>  70
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TMPRSS2

<400>  70

Gly Gly Arg 
1           


<210>  71
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Legumain

<400>  71

Ala Ala Asn 
1           


<210>  72
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ST14 (Matriptase)

<400>  72

Gln Ala Arg 
1           


<210>  73
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C1s cleavage site

<400>  73

Tyr Leu Gly Arg Ser Tyr Lys Val 
1               5               


<210>  74
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C1s cleavage site


<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa can be any naturally occurring amino acid

<400>  74

Met Gln Leu Gly Arg Xaa 
1               5       


<210>  75
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MASP2 cleavage site

<400>  75

Ser Leu Gly Arg Lys Ile Gln Ile 
1               5               


<210>  76
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C2a and Bb cleavage site

<400>  76

Gly Leu Ala Arg Ser Asn Leu Asp Glu 
1               5                   


<210>  77
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  uPa cleavage site

<400>  77

Thr Tyr Ser Arg Ser Arg Tyr Leu 
1               5               


<210>  78
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  uPa cleavage site

<400>  78

Lys Lys Ser Pro Gly Arg Val Val Gly Gly Ser Val 
1               5                   10          


<210>  79
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  uPa cleavage site

<400>  79

Asn Ser Gly Arg Ala Val Thr Tyr 
1               5               


<210>  80
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  uPa cleavage site

<400>  80

Ala Phe Lys 
1           


<210>  81
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  tissue-type plasminogen activator (tPA)

<400>  81

Gly Gly Ser Gly Gln Arg Gly Arg Lys Ala Leu Glu 
1               5                   10          


<210>  82
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADAM10

<400>  82

Pro Arg Tyr Glu Ala Tyr Lys Met Gly Lys 
1               5                   10  


<210>  83
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADAM12

<400>  83

Leu Ala Gln Ala Phe 
1               5   


<210>  84
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADAM17

<400>  84

Glu His Ala Asp Leu Leu Ala Val Val Ala Lys 
1               5                   10      


<210>  85
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  flexible amino acid linker (may be presented in repeating 
       fashion)

<400>  85

Gly Gly Gly Gly Ser 
1               5   


<210>  86
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  flexible amino acid linker (may be presented in repeating 
       fashion)

<400>  86

Gly Gly Gly Ser 
1               


<210>  87
<211>  2
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  flexible amino acid linker (may be presented in repeating 
       fashion)

<400>  87

Gly Ser 
1       


<210>  88
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  flexible amino acid linker (may be presented in repeating 
       fashion)

<400>  88

Gly Ser Gly Gly Ser 
1               5   


<210>  89
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  flexible amino acid linker (may be presented in repeating 
       fashion)

<400>  89

Gly Gly Ser Gly 
1               


<210>  90
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  flexible amino acid linker (may be presented in repeating 
       fashion)

<400>  90

Gly Gly Ser Gly Gly 
1               5   


<210>  91
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  flexible amino acid linker (may be presented in repeating 
       fashion)

<400>  91

Gly Ser Gly Ser Gly 
1               5   


<210>  92
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  flexible amino acid linker (may be presented in repeating 
       fashion)

<400>  92

Gly Ser Gly Gly Gly 
1               5   


<210>  93
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  flexible amino acid linker (may be presented in repeating 
       fashion)

<400>  93

Gly Gly Gly Ser Gly 
1               5   


<210>  94
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  flexible amino acid linker (may be presented in repeating 
       fashion)

<400>  94

Gly Ser Ser Ser Gly 
1               5   


<210>  95
<211>  51
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Anti-EGFR aptamer (tight binder with Kd=2.4 nM)

<400>  95
ugccgcuaua augcacggau uuaaucgccg uagaaaagca ugucaaagcc g                51


<210>  96
<211>  51
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Anti-EGFR aptamer

<400>  96
uggcgcuaaa uagcacggaa auaaucgccg uagaaaagca ugucaaagcc g                51


<210>  97
<211>  51
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Anti-EGFR aptamer

<400>  97
ugcuaguaua ucgcacggau uuaaucgccg uagaaaagca ugucaaagcc g                51


<210>  98
<211>  51
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Anti-EGFR aptamer

<400>  98
ugccgccaua ucacacggau uuaaucgccg uagaaaagca ugucaaagcc g                51


<210>  99
<211>  51
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Anti-EGFR aptamer

<400>  99
uuccgcugua uaacacggac uuaaucgccg uaguaaagca ugucaaagcc g                51


<210>  100
<211>  51
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Anti-EGFR aptamer

<400>  100
ugucgcucua uugcacggau uuaaucgccg uagaaaagca ugucaaagcc g                51


<210>  101
<211>  51
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Anti-EGFR aptamer

<400>  101
ugcugcuuua ucccacauau uuuuuccccu cauaacaaua uuucuccccc c                51


<210>  102
<211>  51
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Anti-EGFR aptamer


<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  n is a, c, g, or u

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  n is a, c, g, or u

<220>
<221>  misc_feature
<222>  (45)..(45)
<223>  n is a, c, g, or u

<220>
<221>  misc_feature
<222>  (47)..(47)
<223>  n is a, c, g, or u

<400>  102
ugcngcuaua ucgcncguau uuaaucgccg uagaaaagca ugucnangcc g                51


<210>  103
<211>  51
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Anti-EGFR aptamer

<400>  103
ugcaaagaaa acgcacguau uuaaucgccg uaguaaagca ugucaaagcc g                51


<210>  104
<211>  53
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Anti-EGFR aptamer

<400>  104
ugcaucacua ucgaaccuau uuaauccacc aaaauaauug caaguccaua cuc              53


<210>  105
<211>  51
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Anti-EGFR aptamer


<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  n is a, c, g, or u

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  n is a, c, g, or u

<220>
<221>  misc_feature
<222>  (48)..(48)
<223>  n is a, c, g, or u

<400>  105
ugccnnaaua acacacnuau auaaucgccg uacaaaauca ugucaaancc g                51


<210>  106
<211>  51
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Anti-EGFR aptamer

<400>  106
ugcagcugua uugcacguau uuaaucgccg uagaaaagca ugucaaagcc g                51


<210>  107
<211>  50
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Anti-EGFR aptamer

<400>  107
uuccgauaau cccgcguacu aaaucaccau agucaacaau uuccaaccuc                  50


<210>  108
<211>  50
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Anti-EGFR aptamer

<400>  108
uccacuauau cacacguauu uaaucgccgu agaaaagcau gucaaagccg                  50


<210>  109
<211>  51
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Anti-EGFR aptamer

<400>  109
ucccucaacc ucgcuacuau uuaaucgccg uagaaaagca ugucaaagcc u                51


<210>  110
<211>  51
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Anti-EGFR aptamer

<400>  110
ugccgcuaua ucacacgaau uuaaucgccg uagaaaagca ugucaaagcc g                51


<210>  111
<211>  51
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Anti-EGFR aptamer

<400>  111
agccccuaga acacacggau uuaaucgccg uagaaaagca ugucaaagcc g                51


<210>  112
<211>  51
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Anti-EGFR aptamer

<400>  112
ugccaauaua uaacacggaa uuaaucgccg uagaaaagca ugucaaagcc g                51


<210>  113
<211>  51
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Anti-EGFR aptamer

<400>  113
ugccgcuaua gcgcacggau uuaaucgccg uagaaaagca ugucaaagcc g                51


<210>  114
<211>  50
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Anti-EGFR aptamer

<400>  114
ugcagauaua ugucacucau uaauccccgu auaaaaacau aacuaagcuc                  50


<210>  115
<211>  51
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Anti-EGFR aptamer

<400>  115
uguagcugua uugcacacau uaaaucgccg uaguaaagca ugucaaagcc g                51


<210>  116
<211>  50
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Anti-EGFR aptamer

<400>  116
uaccaauaua ucgccacaca uaaucgccgu agaaaagcau gucaaagccg                  50


<210>  117
<211>  51
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Anti-EGFR aptamer

<400>  117
ugccgcuaug cccacggaau uuaaucgccg uagaaaaaca ugucaaaguc g                51


<210>  118
<211>  51
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Anti-EGFR aptamer

<400>  118
ugccgcuauu uagcacggau uaaaucgccg uagaaaagca ugucaaagcc g                51


<210>  119
<211>  51
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Anti-EGFR aptamer


<220>
<221>  misc_feature
<222>  (45)..(45)
<223>  n is a, c, g, or u

<400>  119
ugccgcuauu uagcacggau uaaaucgccg uagaaaagca ugucnaagcc g                51


<210>  120
<211>  51
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Anti-EGFR aptamer


<220>
<221>  misc_feature
<222>  (41)..(41)
<223>  n is a, c, g, or u

<400>  120
uguaguaaua ugacacggau uuaaucgccg uagaaaagca ngucaaagcc u                51


<210>  121
<211>  51
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Anti-EGFR aptamer

<400>  121
ugucgccauu acgcacggau uuaaucgccg uagaaaagca ugucaaagcc g                51


<210>  122
<211>  51
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Anti-EGFR aptamer

<400>  122
ugcccccaaa cuacacaaau uuaaucgccg uauaaaagca ugucaaagcc g                51


<210>  123
<211>  49
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Anti-EGFR aptamer

<400>  123
ugcacuaucu cacacguacu aaucgccgua uaaaagcaug ucaaagccg                   49


<210>  124
<211>  51
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Anti-EGFR aptamer

<400>  124
ugucgcaaua auacacuaau uuaaucgccg uagaaaagca ugucaaagcc g                51


<210>  125
<211>  49
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Anti-EGFR aptamer

<400>  125
ugcaacaaua uagcacguau uuaaucgccg uaguaaagca ugucaaagg                   49


<210>  126
<211>  51
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Anti-EGFR aptamer

<400>  126
cuaccacaaa ucccacauau uuaaucuccc aaucaaaucu uguccauucc c                51


<210>  127
<211>  51
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Anti-EGFR aptamer

<400>  127
ugcccuaaac ucacacggau auaaucgccg uagaaaagca ugucaaagcc g                51


<210>  128
<211>  51
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Anti-EGFR aptamer

<400>  128
uugucguaug ucacacguau uaaaucgccg uauaaaagca ugucaaagcc g                51


<210>  129
<211>  51
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Anti-EGFR aptamer

<400>  129
uuccgcuaua acacacggag aaaaucgccg uaguaaagca ugucaaagcc g                51


<210>  130
<211>  51
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Anti-EGFR aptamer

<400>  130
ugccgauaua acgcacggau auaaucgccg uagaaaagca ugucaaagcc g                51


<210>  131
<211>  51
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Anti-EGFR aptamer

<400>  131
ugccauuaua cagcacggau uuaaucgccg uagaaaagca ugucaaagcc g                51


<210>  132
<211>  50
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Anti-EGFR aptamer

<400>  132
uccagaaaua ugcacacauu uaaucgccgu agaaaagcau gucaaagccg                  50


<210>  133
<211>  50
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Anti-EGFR aptamer

<400>  133
uccgcuaaac aacacggaua caaucgccgu agaaaagcau guccaagccg                  50


<210>  134
<211>  49
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Anti-EGFR aptamer


<220>
<221>  misc_feature
<222>  (46)..(48)
<223>  n is a, c, g, or u

<400>  134
ugcacuaucu cacacguacu aaucgccgua uaaaagcaug ucaaannng                   49


<210>  135
<211>  50
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Anti-EGFR aptamer


<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  n is a, c, g, or u

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  n is a, c, g, or u

<220>
<221>  misc_feature
<222>  (8)..(10)
<223>  n is a, c, g, or u

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  n is a, c, g, or u

<220>
<221>  misc_feature
<222>  (45)..(45)
<223>  n is a, c, g, or u

<400>  135
aungcnannn uacacguauu naaucgccgu agaaaagcau gucanagccg                  50


<210>  136
<211>  51
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Anti-EGFR aptamer

<400>  136
ugcugcuaua uugcaauuuu uuaaacuaag uagaaaacca uguacaaguc g                51


<210>  137
<211>  51
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Anti-EGFR aptamer

<400>  137
ugucgccaua uugcacggau uuaaucgccg uagaaaagca uguccaagcc g                51


<210>  138
<211>  52
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Anti-EGFR aptamer

<400>  138
ugccguuaua acccacggaa uuuaaccucc guagaaaagc augucaaagc cg               52


<210>  139
<211>  52
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Anti-EGFR aptamer


<220>
<221>  misc_feature
<222>  (40)..(40)
<223>  n is a, c, g, or u

<400>  139
ugugaauaua uaucacggau uuaaucgccg uauaaaagcn augucaaagc cg               52


<210>  140
<211>  51
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Anti-EGFR aptamer


<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  n is a, c, g, or u

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  n is a, c, g, or u

<400>  140
ugccgauaun nancacggau uuaaucgccg uagaaaagca uguccaagcc g                51


<210>  141
<211>  50
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Anti-EGFR aptamer

<400>  141
ugucacuaaa uugcacguau auaaucgccg uaguaagcau gucaaagccg                  50


<210>  142
<211>  51
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Anti-EGFR aptamer

<400>  142
ugcaaccaua aagcacguaa uaaaucgccg uauauaagca ugucaaagcc g                51


<210>  143
<211>  50
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Anti-EGFR aptamer

<400>  143
ugccgcuaua uagcacguau uaaucgccgu aguaaagcau gucaaagccg                  50


<210>  144
<211>  52
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Anti-EGFR aptamer

<400>  144
ugccgcuaua gcacacggaa uuuaaucgcc guaguaaagc augucaaagc cg               52


<210>  145
<211>  51
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Anti-EGFR aptamer


<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  n is a, c, g, or u

<220>
<221>  misc_feature
<222>  (45)..(45)
<223>  n is a, c, g, or u

<400>  145
ugcagguaua uaacncggau uuaaucgccg uagaaaagca ugucnaagcc g                51


<210>  146
<211>  51
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Anti-EGFR aptamer

<400>  146
ugcuccuaua acacacggau uuaaucgccg uagaaaagca uguccaagcc g                51


<210>  147
<211>  51
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Anti-EGFR aptamer

<400>  147
ugcccguaau ugcacggauu uaaucgccgu agaaaagcau guccaagccg g                51


<210>  148
<211>  51
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Anti-EGFR aptamer


<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  n is a, c, g, or u

<220>
<221>  misc_feature
<222>  (44)..(44)
<223>  n is a, c, g, or u

<400>  148
acucccuaua ungcaacuac auaaucgccg uaaauaagca uguncaagcc g                51


<210>  149
<211>  54
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Anti-EGFR aptamer

<400>  149
ugaagcuaga ucacacuaaa uuaaucgccg uagaaaagca ugucaaaaaa gccg             54


<210>  150
<211>  52
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Anti-EGFR aptamer

<400>  150
ugacucuuua ucccccguac auuauucacc gaaccaaagc auuaccaucc cc               52


<210>  151
<211>  51
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Anti-EGFR aptamer

<400>  151
ugacgcccua acacacguau auaaucgccg uagaaaagca ugucaaagcc g                51


<210>  152
<211>  51
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Anti-EGFR aptamer

<400>  152
ugucgcaaaa uagcacguau uuaaucgccg uagaaaagca uguccaagcc g                51


<210>  153
<211>  51
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Anti-EGFR aptamer

<400>  153
ugaguguaua auucacguau uuaaucgccg uagaaaagca ugucaaagcc g                51


<210>  154
<211>  51
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Anti-EGFR aptamer

<400>  154
ugcuacuaua ucguagguaa cuaaucgccc uacaaacuca cucuaaaacc g                51


<210>  155
<211>  53
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Anti-EGFR aptamer

<400>  155
uuacgcuaua ucacacggaa uuuuaaucgc cguagaaaag cauguccaag ccg              53


<210>  156
<211>  51
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Anti-EGFR aptamer

<400>  156
cccaucugua cuacaggaau uuaaucgccg uagaaaagca uguccaagcc g                51


<210>  157
<211>  51
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Anti-EGFR aptamer

<400>  157
ugcccauaaa uagcacggau uuaaucgccg uagaaaagca uguccaagcc g                51


<210>  158
<211>  51
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Anti-EGFR aptamer

<400>  158
ugccgcaaua acauacacau auaaucgccg uagaaaagca ugucaaagcc g                51


<210>  159
<211>  51
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Anti-EGFR aptamer

<400>  159
ugcaacuaua ucgcacguau guaaucgccg uagaaaaagc augucaaagc c                51


<210>  160
<211>  51
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Anti-EGFR aptamer

<400>  160
uuccgcuaua uagcacggaa uuaaucgccg uagaaaagca uguccaagcc g                51


<210>  161
<211>  51
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Anti-EGFR aptamer

<400>  161
uuccgcuaag ucacacgaaa uuaaucgccg uagaaaagca uguccaagcc g                51


<210>  162
<211>  51
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Anti-EGFR aptamer

<400>  162
uguagcaaua ucacacguaa uuaaucgccg uauauaagca ugucaaagcc g                51


<210>  163
<211>  51
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Anti-EGFR aptamer

<400>  163
ugccguuaua uaucacggau uuaaucgccg uagaaaagca uguccaagcc g                51


<210>  164
<211>  49
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Anti-EGFR aptamer

<400>  164
uaacacauau aucaaguaac uuaucuccuu aguaaccauc uccaagccg                   49


<210>  165
<211>  502
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Construct

<400>  165

Glu Leu Val Met Thr Gln Ser Pro Ser Ser Leu Thr Val Thr Ala Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Asp Tyr Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Glu Val Gln Leu Leu Glu Gln Ser Gly Ala Glu Leu Val Arg Pro Gly 
    130                 135                 140                 


Thr Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ala Phe Thr Asn 
145                 150                 155                 160 


Tyr Trp Leu Gly Trp Val Lys Gln Arg Pro Gly His Gly Leu Glu Trp 
                165                 170                 175     


Ile Gly Asp Ile Phe Pro Gly Ser Gly Asn Ile His Tyr Asn Glu Lys 
            180                 185                 190         


Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala 
        195                 200                 205             


Tyr Met Gln Leu Ser Ser Leu Thr Phe Glu Asp Ser Ala Val Tyr Phe 
    210                 215                 220                 


Cys Ala Arg Leu Arg Asn Trp Asp Glu Pro Met Asp Tyr Trp Gly Gln 
225                 230                 235                 240 


Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Asp Val Gln 
                245                 250                 255     


Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys 
            260                 265                 270         


Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Tyr Thr Met His 
        275                 280                 285             


Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile Gly Tyr Ile 
    290                 295                 300                 


Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Ala Asp Ser Val Lys Gly Arg 
305                 310                 315                 320 


Phe Thr Ile Thr Thr Asp Lys Ser Thr Ser Thr Ala Tyr Met Glu Leu 
                325                 330                 335     


Ser Ser Leu Arg Ser Glu Asp Thr Ala Thr Tyr Tyr Cys Ala Arg Tyr 
            340                 345                 350         


Tyr Asp Asp His Tyr Cys Leu Asp Tyr Trp Gly Gln Gly Thr Thr Val 
        355                 360                 365             


Thr Val Ser Ser Gly Glu Gly Thr Ser Thr Gly Ser Gly Gly Ser Gly 
    370                 375                 380                 


Gly Ser Gly Gly Ala Asp Asp Ile Val Leu Thr Gln Ser Pro Ala Thr 
385                 390                 395                 400 


Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser 
                405                 410                 415     


Gln Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
            420                 425                 430         


Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys Val Ala Ser Gly Val Pro 
        435                 440                 445             


Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile 
    450                 455                 460                 


Asn Ser Leu Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp 
465                 470                 475                 480 


Ser Ser Asn Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
                485                 490                 495     


His His His His His His 
            500         


<210>  166
<211>  396
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Construct

<400>  166

Glu Leu Val Met Thr Gln Ser Pro Ser Ser Leu Thr Val Thr Ala Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Asp Tyr Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Glu Val Gln Leu Leu Glu Gln Ser Gly Ala Glu Leu Val Arg Pro Gly 
    130                 135                 140                 


Thr Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ala Phe Thr Asn 
145                 150                 155                 160 


Tyr Trp Leu Gly Trp Val Lys Gln Arg Pro Gly His Gly Leu Glu Trp 
                165                 170                 175     


Ile Gly Asp Ile Phe Pro Gly Ser Gly Asn Ile His Tyr Asn Glu Lys 
            180                 185                 190         


Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala 
        195                 200                 205             


Tyr Met Gln Leu Ser Ser Leu Thr Phe Glu Asp Ser Ala Val Tyr Phe 
    210                 215                 220                 


Cys Ala Arg Leu Arg Asn Trp Asp Glu Pro Met Asp Tyr Trp Gly Gln 
225                 230                 235                 240 


Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Asp Val Gln 
                245                 250                 255     


Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys 
            260                 265                 270         


Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Tyr Thr Met His 
        275                 280                 285             


Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile Gly Tyr Ile 
    290                 295                 300                 


Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Ala Asp Ser Val Lys Gly Arg 
305                 310                 315                 320 


Phe Thr Ile Thr Thr Asp Lys Ser Thr Ser Thr Ala Tyr Met Glu Leu 
                325                 330                 335     


Ser Ser Leu Arg Ser Glu Asp Thr Ala Thr Tyr Tyr Cys Ala Arg Tyr 
            340                 345                 350         


Tyr Asp Asp His Tyr Cys Leu Asp Tyr Trp Gly Gln Gly Thr Thr Val 
        355                 360                 365             


Thr Val Ser Ser Gly Glu Gly Thr Ser Thr Gly Ser Gly Gly Ser Gly 
    370                 375                 380                 


Gly Ser Gly Gly Ala Asp His His His His His His 
385                 390                 395     


<210>  167
<211>  365
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Construct

<400>  167

Glu Leu Val Met Thr Gln Ser Pro Ser Ser Leu Thr Val Thr Ala Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Asp Tyr Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Glu Val Gln Leu Leu Glu Gln Ser Gly Ala Glu Leu Val Arg Pro Gly 
    130                 135                 140                 


Thr Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ala Phe Thr Asn 
145                 150                 155                 160 


Tyr Trp Leu Gly Trp Val Lys Gln Arg Pro Gly His Gly Leu Glu Trp 
                165                 170                 175     


Ile Gly Asp Ile Phe Pro Gly Ser Gly Asn Ile His Tyr Asn Glu Lys 
            180                 185                 190         


Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala 
        195                 200                 205             


Tyr Met Gln Leu Ser Ser Leu Thr Phe Glu Asp Ser Ala Val Tyr Phe 
    210                 215                 220                 


Cys Ala Arg Leu Arg Asn Trp Asp Glu Pro Met Asp Tyr Trp Gly Gln 
225                 230                 235                 240 


Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Asp Ile Val 
                245                 250                 255     


Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala 
            260                 265                 270         


Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Tyr Met Asn Trp Tyr 
        275                 280                 285             


Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp Thr Ser 
    290                 295                 300                 


Lys Val Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly 
305                 310                 315                 320 


Thr Asp Tyr Ser Leu Thr Ile Asn Ser Leu Glu Ala Glu Asp Ala Ala 
                325                 330                 335     


Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Leu Thr Phe Gly Gly 
            340                 345                 350         


Gly Thr Lys Val Glu Ile Lys His His His His His His 
        355                 360                 365 


<210>  168
<211>  511
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Construct

<400>  168

Glu Leu Val Met Thr Gln Ser Pro Ser Ser Leu Thr Val Thr Ala Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Asp Tyr Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Glu Val Gln Leu Leu Glu Gln Ser Gly Ala Glu Leu Val Arg Pro Gly 
    130                 135                 140                 


Thr Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ala Phe Thr Asn 
145                 150                 155                 160 


Tyr Trp Leu Gly Trp Val Lys Gln Arg Pro Gly His Gly Leu Glu Trp 
                165                 170                 175     


Ile Gly Asp Ile Phe Pro Gly Ser Gly Asn Ile His Tyr Asn Glu Lys 
            180                 185                 190         


Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala 
        195                 200                 205             


Tyr Met Gln Leu Ser Ser Leu Thr Phe Glu Asp Ser Ala Val Tyr Phe 
    210                 215                 220                 


Cys Ala Arg Leu Arg Asn Trp Asp Glu Pro Met Asp Tyr Trp Gly Gln 
225                 230                 235                 240 


Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Asp Val Gln 
                245                 250                 255     


Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys 
            260                 265                 270         


Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Tyr Thr Met His 
        275                 280                 285             


Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile Gly Tyr Ile 
    290                 295                 300                 


Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Ala Asp Ser Val Lys Gly Arg 
305                 310                 315                 320 


Phe Thr Ile Thr Thr Asp Lys Ser Thr Ser Thr Ala Tyr Met Glu Leu 
                325                 330                 335     


Ser Ser Leu Arg Ser Glu Asp Thr Ala Thr Tyr Tyr Cys Ala Arg Tyr 
            340                 345                 350         


Tyr Asp Asp His Tyr Cys Leu Asp Tyr Trp Gly Gln Gly Thr Thr Val 
        355                 360                 365             


Thr Val Ser Ser Gly Glu Gly Thr Ser Thr Gly Ser Gly Ala Ile Pro 
    370                 375                 380                 


Val Ser Leu Arg Gly Ser Gly Gly Ser Gly Gly Ala Asp Asp Ile Val 
385                 390                 395                 400 


Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala 
                405                 410                 415     


Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser Tyr Leu Ala 
            420                 425                 430         


Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly 
        435                 440                 445             


Ala Ser Ser Arg Ala Thr Gly Val Pro Ala Arg Phe Ser Gly Ser Gly 
    450                 455                 460                 


Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp 
465                 470                 475                 480 


Phe Ala Thr Tyr Tyr Cys Leu Gln Ile Tyr Asn Met Pro Ile Thr Phe 
                485                 490                 495     


Gly Gln Gly Thr Lys Val Glu Ile Lys His His His His His His 
            500                 505                 510     


<210>  169
<211>  508
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Construct

<400>  169

Glu Leu Val Met Thr Gln Ser Pro Ser Ser Leu Thr Val Thr Ala Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Asp Tyr Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Glu Val Gln Leu Leu Glu Gln Ser Gly Ala Glu Leu Val Arg Pro Gly 
    130                 135                 140                 


Thr Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ala Phe Thr Asn 
145                 150                 155                 160 


Tyr Trp Leu Gly Trp Val Lys Gln Arg Pro Gly His Gly Leu Glu Trp 
                165                 170                 175     


Ile Gly Asp Ile Phe Pro Gly Ser Gly Asn Ile His Tyr Asn Glu Lys 
            180                 185                 190         


Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala 
        195                 200                 205             


Tyr Met Gln Leu Ser Ser Leu Thr Phe Glu Asp Ser Ala Val Tyr Phe 
    210                 215                 220                 


Cys Ala Arg Leu Arg Asn Trp Asp Glu Pro Met Asp Tyr Trp Gly Gln 
225                 230                 235                 240 


Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Asp Ile Val 
                245                 250                 255     


Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala 
            260                 265                 270         


Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Tyr Met Asn Trp Tyr 
        275                 280                 285             


Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp Thr Ser 
    290                 295                 300                 


Lys Val Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly 
305                 310                 315                 320 


Thr Asp Tyr Ser Leu Thr Ile Asn Ser Leu Glu Ala Glu Asp Ala Ala 
                325                 330                 335     


Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Leu Thr Phe Gly Gly 
            340                 345                 350         


Gly Thr Lys Val Glu Ile Lys Gly Glu Gly Thr Ser Thr Gly Ser Gly 
        355                 360                 365             


Ala Ile Pro Val Ser Leu Arg Gly Ser Gly Gly Ser Gly Gly Ala Asp 
    370                 375                 380                 


Asp Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
385                 390                 395                 400 


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 
                405                 410                 415     


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
            420                 425                 430         


Gly Trp Ile Asn Pro Asn Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe 
        435                 440                 445             


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
    450                 455                 460                 


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
465                 470                 475                 480 


Ala Arg Asp Phe Leu Ser Gly Tyr Leu Asp Tyr Trp Gly Gln Gly Thr 
                485                 490                 495     


Leu Val Thr Val Ser Ser His His His His His His 
            500                 505             


<210>  170
<211>  511
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Construct

<400>  170

Glu Leu Val Met Thr Gln Ser Pro Ser Ser Leu Thr Val Thr Ala Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Asp Tyr Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Glu Val Gln Leu Leu Glu Gln Ser Gly Ala Glu Leu Val Arg Pro Gly 
    130                 135                 140                 


Thr Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ala Phe Thr Asn 
145                 150                 155                 160 


Tyr Trp Leu Gly Trp Val Lys Gln Arg Pro Gly His Gly Leu Glu Trp 
                165                 170                 175     


Ile Gly Asp Ile Phe Pro Gly Ser Gly Asn Ile His Tyr Asn Glu Lys 
            180                 185                 190         


Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala 
        195                 200                 205             


Tyr Met Gln Leu Ser Ser Leu Thr Phe Glu Asp Ser Ala Val Tyr Phe 
    210                 215                 220                 


Cys Ala Arg Leu Arg Asn Trp Asp Glu Pro Met Asp Tyr Trp Gly Gln 
225                 230                 235                 240 


Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Asp Val Gln 
                245                 250                 255     


Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys 
            260                 265                 270         


Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Tyr Thr Met His 
        275                 280                 285             


Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile Gly Tyr Ile 
    290                 295                 300                 


Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Ala Asp Ser Val Lys Gly Arg 
305                 310                 315                 320 


Phe Thr Ile Thr Thr Asp Lys Ser Thr Ser Thr Ala Tyr Met Glu Leu 
                325                 330                 335     


Ser Ser Leu Arg Ser Glu Asp Thr Ala Thr Tyr Tyr Cys Ala Arg Tyr 
            340                 345                 350         


Tyr Asp Asp His Tyr Cys Leu Asp Tyr Trp Gly Gln Gly Thr Thr Val 
        355                 360                 365             


Thr Val Ser Ser Gly Glu Gly Thr Ser Thr Gly Ser Gly Gly Gly Gly 
    370                 375                 380                 


Ser Gly Gly Gly Gly Ser Gly Gly Ser Gly Gly Ala Asp Asp Ile Val 
385                 390                 395                 400 


Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala 
                405                 410                 415     


Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser Tyr Leu Ala 
            420                 425                 430         


Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly 
        435                 440                 445             


Ala Ser Ser Arg Ala Thr Gly Val Pro Ala Arg Phe Ser Gly Ser Gly 
    450                 455                 460                 


Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp 
465                 470                 475                 480 


Phe Ala Thr Tyr Tyr Cys Leu Gln Ile Tyr Asn Met Pro Ile Thr Phe 
                485                 490                 495     


Gly Gln Gly Thr Lys Val Glu Ile Lys His His His His His His 
            500                 505                 510     


<210>  171
<211>  508
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Construct

<400>  171

Glu Leu Val Met Thr Gln Ser Pro Ser Ser Leu Thr Val Thr Ala Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Asp Tyr Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Glu Val Gln Leu Leu Glu Gln Ser Gly Ala Glu Leu Val Arg Pro Gly 
    130                 135                 140                 


Thr Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ala Phe Thr Asn 
145                 150                 155                 160 


Tyr Trp Leu Gly Trp Val Lys Gln Arg Pro Gly His Gly Leu Glu Trp 
                165                 170                 175     


Ile Gly Asp Ile Phe Pro Gly Ser Gly Asn Ile His Tyr Asn Glu Lys 
            180                 185                 190         


Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala 
        195                 200                 205             


Tyr Met Gln Leu Ser Ser Leu Thr Phe Glu Asp Ser Ala Val Tyr Phe 
    210                 215                 220                 


Cys Ala Arg Leu Arg Asn Trp Asp Glu Pro Met Asp Tyr Trp Gly Gln 
225                 230                 235                 240 


Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Asp Ile Val 
                245                 250                 255     


Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala 
            260                 265                 270         


Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Tyr Met Asn Trp Tyr 
        275                 280                 285             


Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp Thr Ser 
    290                 295                 300                 


Lys Val Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly 
305                 310                 315                 320 


Thr Asp Tyr Ser Leu Thr Ile Asn Ser Leu Glu Ala Glu Asp Ala Ala 
                325                 330                 335     


Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Leu Thr Phe Gly Gly 
            340                 345                 350         


Gly Thr Lys Val Glu Ile Lys Gly Glu Gly Thr Ser Thr Gly Ser Gly 
        355                 360                 365             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Ser Gly Gly Ala Asp 
    370                 375                 380                 


Asp Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
385                 390                 395                 400 


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 
                405                 410                 415     


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
            420                 425                 430         


Gly Trp Ile Asn Pro Asn Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe 
        435                 440                 445             


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
    450                 455                 460                 


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
465                 470                 475                 480 


Ala Arg Asp Phe Leu Ser Gly Tyr Leu Asp Tyr Trp Gly Gln Gly Thr 
                485                 490                 495     


Leu Val Thr Val Ser Ser His His His His His His 
            500                 505             


<210>  172
<211>  380
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Construct

<400>  172

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Tyr Phe Asp Phe Asp Ser Tyr 
            20                  25                  30          


Glu Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ser Ile Tyr His Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Thr Leu Arg Ala Glu Asp Thr Ala Thr Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Val Asn Met Asp Arg Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Ser Gly Gly Gly Gly Ser Asp Val Gln Leu Val Gln 
        115                 120                 125             


Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys 
    130                 135                 140                 


Lys Ala Ser Gly Tyr Thr Phe Thr Arg Tyr Thr Met His Trp Val Arg 
145                 150                 155                 160 


Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser 
                165                 170                 175     


Arg Gly Tyr Thr Asn Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
            180                 185                 190         


Thr Thr Asp Lys Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu 
        195                 200                 205             


Arg Ser Glu Asp Thr Ala Thr Tyr Tyr Cys Ala Arg Tyr Tyr Asp Asp 
    210                 215                 220                 


His Tyr Cys Leu Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser 
225                 230                 235                 240 


Ser Gly Glu Gly Thr Ser Thr Gly Ser Gly Ala Ile Pro Val Ser Leu 
                245                 250                 255     


Arg Gly Ser Gly Gly Ser Gly Gly Ala Asp Asp Ile Val Leu Thr Gln 
            260                 265                 270         


Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser 
        275                 280                 285             


Cys Arg Ala Ser Gln Ser Val Ser Ser Ser Tyr Leu Ala Trp Tyr Gln 
    290                 295                 300                 


Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser Ser 
305                 310                 315                 320 


Arg Ala Thr Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr 
                325                 330                 335     


Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala Thr 
            340                 345                 350         


Tyr Tyr Cys Leu Gln Ile Tyr Asn Met Pro Ile Thr Phe Gly Gln Gly 
        355                 360                 365             


Thr Lys Val Glu Ile Lys His His His His His His 
    370                 375                 380 


<210>  173
<211>  508
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Construct

<400>  173

Asp Ile Gln Met Thr Gln Ser Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Ser Ala Ser Gln Gly Ile Asn Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Glu Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Ile Gly Thr Tyr Tyr Cys Gln Gln Tyr Ser Lys Leu Pro Arg 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Gly Gly Gly Gly 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Gln 
        115                 120                 125             


Gln Ser Gly Ser Glu Leu Met Met Pro Gly Ala Ser Val Lys Ile Ser 
    130                 135                 140                 


Cys Lys Ala Thr Gly Tyr Thr Phe Ser Asn Tyr Trp Ile Glu Trp Val 
145                 150                 155                 160 


Lys Gln Arg Pro Gly His Gly Leu Glu Trp Ile Gly Glu Ile Leu Pro 
                165                 170                 175     


Gly Thr Gly Arg Thr Ile Tyr Asn Glu Lys Phe Lys Gly Lys Ala Thr 
            180                 185                 190         


Phe Thr Ala Asp Ile Ser Ser Asn Thr Val Gln Met Gln Leu Ser Ser 
        195                 200                 205             


Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Arg Asp Tyr 
    210                 215                 220                 


Tyr Gly Asn Phe Tyr Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser 
225                 230                 235                 240 


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Asp Val Gln Leu Val Gln 
                245                 250                 255     


Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys 
            260                 265                 270         


Lys Ala Ser Gly Tyr Thr Phe Thr Arg Tyr Thr Met His Trp Val Arg 
        275                 280                 285             


Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser 
    290                 295                 300                 


Arg Gly Tyr Thr Asn Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
305                 310                 315                 320 


Thr Thr Asp Lys Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu 
                325                 330                 335     


Arg Ser Glu Asp Thr Ala Thr Tyr Tyr Cys Ala Arg Tyr Tyr Asp Asp 
            340                 345                 350         


His Tyr Cys Leu Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser 
        355                 360                 365             


Ser Gly Glu Gly Thr Ser Thr Gly Ser Gly Ala Ile Pro Val Ser Leu 
    370                 375                 380                 


Arg Gly Ser Gly Gly Ser Gly Gly Ala Asp Asp Ile Val Leu Thr Gln 
385                 390                 395                 400 


Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser 
                405                 410                 415     


Cys Arg Ala Ser Gln Ser Val Ser Ser Ser Tyr Leu Ala Trp Tyr Gln 
            420                 425                 430         


Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser Ser 
        435                 440                 445             


Arg Ala Thr Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr 
    450                 455                 460                 


Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala Thr 
465                 470                 475                 480 


Tyr Tyr Cys Leu Gln Ile Tyr Asn Met Pro Ile Thr Phe Gly Gln Gly 
                485                 490                 495     


Thr Lys Val Glu Ile Lys His His His His His His 
            500                 505             


<210>  174
<211>  403
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Construct

<400>  174

Gln Val Lys Leu Glu Glu Ser Gly Gly Gly Ser Val Gln Thr Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Thr Cys Ala Ala Ser Gly Arg Thr Ser Arg Ser Tyr 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Arg Gly Asp Ser Thr Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Asp 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ala Ala Gly Ser Ala Trp Tyr Gly Thr Leu Tyr Glu Tyr Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Val Gln Leu Val Gln 
145                 150                 155                 160 


Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys 
                165                 170                 175     


Lys Ala Ser Gly Tyr Thr Phe Thr Arg Tyr Thr Met His Trp Val Arg 
            180                 185                 190         


Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser 
        195                 200                 205             


Arg Gly Tyr Thr Asn Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
    210                 215                 220                 


Thr Thr Asp Lys Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu 
225                 230                 235                 240 


Arg Ser Glu Asp Thr Ala Thr Tyr Tyr Cys Ala Arg Tyr Tyr Asp Asp 
                245                 250                 255     


His Tyr Cys Leu Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser 
            260                 265                 270         


Ser Gly Glu Gly Thr Ser Thr Gly Ser Gly Gly Ser Gly Gly Ser Gly 
        275                 280                 285             


Gly Ala Asp Asp Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu 
    290                 295                 300                 


Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val 
305                 310                 315                 320 


Ser Tyr Met Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg 
                325                 330                 335     


Trp Ile Tyr Asp Thr Ser Lys Val Ala Ser Gly Val Pro Ala Arg Phe 
            340                 345                 350         


Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Asn Ser Leu 
        355                 360                 365             


Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn 
    370                 375                 380                 


Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys His His His 
385                 390                 395                 400 


His His His 
            


<210>  175
<211>  406
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Construct

<400>  175

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Val Ala Ile Asn Trp Ser Ser Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Met Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Tyr Gln Ile Asn Ser Gly Asn Tyr Asn Phe Lys Asp Tyr 
            100                 105                 110         


Glu Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Val Gln 
145                 150                 155                 160 


Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys 
                165                 170                 175     


Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Tyr Thr Met His 
            180                 185                 190         


Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile Gly Tyr Ile 
        195                 200                 205             


Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Ala Asp Ser Val Lys Gly Arg 
    210                 215                 220                 


Phe Thr Ile Thr Thr Asp Lys Ser Thr Ser Thr Ala Tyr Met Glu Leu 
225                 230                 235                 240 


Ser Ser Leu Arg Ser Glu Asp Thr Ala Thr Tyr Tyr Cys Ala Arg Tyr 
                245                 250                 255     


Tyr Asp Asp His Tyr Cys Leu Asp Tyr Trp Gly Gln Gly Thr Thr Val 
            260                 265                 270         


Thr Val Ser Ser Gly Glu Gly Thr Ser Thr Gly Ser Gly Gly Ser Gly 
        275                 280                 285             


Gly Ser Gly Gly Ala Asp Asp Ile Val Leu Thr Gln Ser Pro Ala Thr 
    290                 295                 300                 


Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser 
305                 310                 315                 320 


Gln Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
                325                 330                 335     


Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys Val Ala Ser Gly Val Pro 
            340                 345                 350         


Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile 
        355                 360                 365             


Asn Ser Leu Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp 
    370                 375                 380                 


Ser Ser Asn Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
385                 390                 395                 400 


His His His His His His 
                405     


<210>  176
<211>  412
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Construct

<400>  176

Gln Val Lys Leu Glu Glu Ser Gly Gly Gly Ser Val Gln Thr Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Thr Cys Ala Ala Ser Gly Arg Thr Ser Arg Ser Tyr 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Arg Gly Asp Ser Thr Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Asp 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ala Ala Gly Ser Ala Trp Tyr Gly Thr Leu Tyr Glu Tyr Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Val Gln Leu Val Gln 
145                 150                 155                 160 


Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys 
                165                 170                 175     


Lys Ala Ser Gly Tyr Thr Phe Thr Arg Tyr Thr Met His Trp Val Arg 
            180                 185                 190         


Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser 
        195                 200                 205             


Arg Gly Tyr Thr Asn Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
    210                 215                 220                 


Thr Thr Asp Lys Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu 
225                 230                 235                 240 


Arg Ser Glu Asp Thr Ala Thr Tyr Tyr Cys Ala Arg Tyr Tyr Asp Asp 
                245                 250                 255     


His Tyr Cys Leu Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser 
            260                 265                 270         


Ser Gly Glu Gly Thr Ser Thr Gly Ser Gly Ala Ile Pro Val Ser Leu 
        275                 280                 285             


Arg Gly Ser Gly Gly Ser Gly Gly Ala Asp Asp Ile Val Leu Thr Gln 
    290                 295                 300                 


Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser 
305                 310                 315                 320 


Cys Arg Ala Ser Gln Ser Val Ser Ser Ser Tyr Leu Ala Trp Tyr Gln 
                325                 330                 335     


Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser Ser 
            340                 345                 350         


Arg Ala Thr Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr 
        355                 360                 365             


Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala Thr 
    370                 375                 380                 


Tyr Tyr Cys Leu Gln Ile Tyr Asn Met Pro Ile Thr Phe Gly Gln Gly 
385                 390                 395                 400 


Thr Lys Val Glu Ile Lys His His His His His His 
                405                 410         


<210>  177
<211>  412
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Construct

<400>  177

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Val Ala Ile Asn Trp Ser Ser Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Met Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Tyr Gln Ile Asn Ser Gly Asn Tyr Asn Phe Lys Asp Tyr 
            100                 105                 110         


Glu Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val 
145                 150                 155                 160 


Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala 
                165                 170                 175     


Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Tyr Met Asn Trp Tyr 
            180                 185                 190         


Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp Thr Ser 
        195                 200                 205             


Lys Val Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly 
    210                 215                 220                 


Thr Asp Tyr Ser Leu Thr Ile Asn Ser Leu Glu Ala Glu Asp Ala Ala 
225                 230                 235                 240 


Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Leu Thr Phe Gly Gly 
                245                 250                 255     


Gly Thr Lys Val Glu Ile Lys Gly Glu Gly Thr Ser Thr Gly Ser Gly 
            260                 265                 270         


Ala Ile Pro Val Ser Leu Arg Gly Ser Gly Gly Ser Gly Gly Ala Asp 
        275                 280                 285             


Asp Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
    290                 295                 300                 


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 
305                 310                 315                 320 


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
                325                 330                 335     


Gly Trp Ile Asn Pro Asn Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe 
            340                 345                 350         


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
        355                 360                 365             


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
    370                 375                 380                 


Ala Arg Asp Phe Leu Ser Gly Tyr Leu Asp Tyr Trp Gly Gln Gly Thr 
385                 390                 395                 400 


Leu Val Thr Val Ser Ser His His His His His His 
                405                 410         


