                         SEQUENCE LISTING

<110>  Kramer, Richard H.
       Lin, Wan-Chen
 
<120>  Light-Regulated GABAA Receptors and Methods of Use Thereof

<130>  BERK-314WO

<150>  US 62/257,150
<151>  2015-11-18

<160>  30    

<170>  PatentIn version 3.5

<210>  1
<211>  456
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Arg Lys Ser Pro Gly Leu Ser Asp Cys Leu Trp Ala Trp Ile Leu 
1               5                   10                  15      


Leu Leu Ser Thr Leu Thr Gly Arg Ser Tyr Gly Gln Pro Ser Leu Gln 
            20                  25                  30          


Asp Glu Leu Lys Asp Asn Thr Thr Val Phe Thr Arg Ile Leu Asp Arg 
        35                  40                  45              


Leu Leu Asp Gly Tyr Asp Asn Arg Leu Arg Pro Gly Leu Gly Glu Arg 
    50                  55                  60                  


Val Thr Glu Val Lys Thr Asp Ile Phe Val Thr Ser Phe Gly Pro Val 
65                  70                  75                  80  


Ser Asp His Asp Met Glu Tyr Thr Ile Asp Val Phe Phe Arg Gln Ser 
                85                  90                  95      


Trp Lys Asp Glu Arg Leu Lys Phe Lys Gly Pro Met Thr Val Leu Arg 
            100                 105                 110         


Leu Asn Asn Leu Met Ala Ser Lys Ile Trp Thr Pro Asp Thr Phe Phe 
        115                 120                 125             


His Asn Gly Lys Lys Ser Val Ala His Asn Met Thr Met Pro Asn Lys 
    130                 135                 140                 


Leu Leu Arg Ile Thr Glu Asp Gly Thr Leu Leu Tyr Thr Met Arg Leu 
145                 150                 155                 160 


Thr Val Arg Ala Glu Cys Pro Met His Leu Glu Asp Phe Pro Met Asp 
                165                 170                 175     


Ala His Ala Cys Pro Leu Lys Phe Gly Ser Tyr Ala Tyr Thr Arg Ala 
            180                 185                 190         


Glu Val Val Tyr Glu Trp Thr Arg Glu Pro Ala Arg Ser Val Val Val 
        195                 200                 205             


Ala Glu Asp Gly Ser Arg Leu Asn Gln Tyr Asp Leu Leu Gly Gln Thr 
    210                 215                 220                 


Val Asp Ser Gly Ile Val Gln Ser Ser Thr Gly Glu Tyr Val Val Met 
225                 230                 235                 240 


Thr Thr His Phe His Leu Lys Arg Lys Ile Gly Tyr Phe Val Ile Gln 
                245                 250                 255     


Thr Tyr Leu Pro Cys Ile Met Thr Val Ile Leu Ser Gln Val Ser Phe 
            260                 265                 270         


Trp Leu Asn Arg Glu Ser Val Pro Ala Arg Thr Val Phe Gly Val Thr 
        275                 280                 285             


Thr Val Leu Thr Met Thr Thr Leu Ser Ile Ser Ala Arg Asn Ser Leu 
    290                 295                 300                 


Pro Lys Val Ala Tyr Ala Thr Ala Met Asp Trp Phe Ile Ala Val Cys 
305                 310                 315                 320 


Tyr Ala Phe Val Phe Ser Ala Leu Ile Glu Phe Ala Thr Val Asn Tyr 
                325                 330                 335     


Phe Thr Lys Arg Gly Tyr Ala Trp Asp Gly Lys Ser Val Val Pro Glu 
            340                 345                 350         


Lys Pro Lys Lys Val Lys Asp Pro Leu Ile Lys Lys Asn Asn Thr Tyr 
        355                 360                 365             


Ala Pro Thr Ala Thr Ser Tyr Thr Pro Asn Leu Ala Arg Gly Asp Pro 
    370                 375                 380                 


Gly Leu Ala Thr Ile Ala Lys Ser Ala Thr Ile Glu Pro Lys Glu Val 
385                 390                 395                 400 


Lys Pro Glu Thr Lys Pro Pro Glu Pro Lys Lys Thr Phe Asn Ser Val 
                405                 410                 415     


Ser Lys Ile Asp Arg Leu Ser Arg Ile Ala Phe Pro Leu Leu Phe Gly 
            420                 425                 430         


Ile Phe Asn Leu Val Tyr Trp Ala Thr Tyr Leu Asn Arg Glu Pro Gln 
        435                 440                 445             


Leu Lys Ala Pro Thr Pro His Gln 
    450                 455     


<210>  2
<211>  456
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Arg Lys Ser Pro Gly Leu Ser Asp Cys Leu Trp Ala Trp Ile Leu 
1               5                   10                  15      


Leu Leu Ser Thr Leu Thr Gly Arg Ser Tyr Gly Gln Pro Ser Leu Gln 
            20                  25                  30          


Asp Glu Leu Lys Asp Asn Thr Thr Val Phe Thr Arg Ile Leu Asp Arg 
        35                  40                  45              


Leu Leu Asp Gly Tyr Asp Asn Arg Leu Arg Pro Gly Leu Gly Glu Arg 
    50                  55                  60                  


Val Thr Glu Val Lys Thr Asp Ile Phe Val Thr Ser Phe Gly Pro Val 
65                  70                  75                  80  


Ser Asp His Asp Met Glu Tyr Thr Ile Asp Val Phe Phe Arg Gln Ser 
                85                  90                  95      


Trp Lys Asp Glu Arg Leu Lys Phe Lys Gly Pro Met Thr Val Leu Arg 
            100                 105                 110         


Leu Asn Asn Leu Met Ala Ser Lys Ile Trp Thr Pro Asp Thr Phe Phe 
        115                 120                 125             


His Asn Gly Lys Lys Ser Val Ala His Asn Met Thr Met Pro Asn Lys 
    130                 135                 140                 


Leu Leu Arg Ile Thr Glu Asp Gly Cys Leu Leu Tyr Thr Met Arg Leu 
145                 150                 155                 160 


Thr Val Arg Ala Glu Cys Pro Met His Leu Glu Asp Phe Pro Met Asp 
                165                 170                 175     


Ala His Ala Cys Pro Leu Lys Phe Gly Ser Tyr Ala Tyr Thr Arg Ala 
            180                 185                 190         


Glu Val Val Tyr Glu Trp Thr Arg Glu Pro Ala Arg Ser Val Val Val 
        195                 200                 205             


Ala Glu Asp Gly Ser Arg Leu Asn Gln Tyr Asp Leu Leu Gly Gln Thr 
    210                 215                 220                 


Val Asp Ser Gly Ile Val Gln Ser Ser Thr Gly Glu Tyr Val Val Met 
225                 230                 235                 240 


Thr Thr His Phe His Leu Lys Arg Lys Ile Gly Tyr Phe Val Ile Gln 
                245                 250                 255     


Thr Tyr Leu Pro Cys Ile Met Thr Val Ile Leu Ser Gln Val Ser Phe 
            260                 265                 270         


Trp Leu Asn Arg Glu Ser Val Pro Ala Arg Thr Val Phe Gly Val Thr 
        275                 280                 285             


Thr Val Leu Thr Met Thr Thr Leu Ser Ile Ser Ala Arg Asn Ser Leu 
    290                 295                 300                 


Pro Lys Val Ala Tyr Ala Thr Ala Met Asp Trp Phe Ile Ala Val Cys 
305                 310                 315                 320 


Tyr Ala Phe Val Phe Ser Ala Leu Ile Glu Phe Ala Thr Val Asn Tyr 
                325                 330                 335     


Phe Thr Lys Arg Gly Tyr Ala Trp Asp Gly Lys Ser Val Val Pro Glu 
            340                 345                 350         


Lys Pro Lys Lys Val Lys Asp Pro Leu Ile Lys Lys Asn Asn Thr Tyr 
        355                 360                 365             


Ala Pro Thr Ala Thr Ser Tyr Thr Pro Asn Leu Ala Arg Gly Asp Pro 
    370                 375                 380                 


Gly Leu Ala Thr Ile Ala Lys Ser Ala Thr Ile Glu Pro Lys Glu Val 
385                 390                 395                 400 


Lys Pro Glu Thr Lys Pro Pro Glu Pro Lys Lys Thr Phe Asn Ser Val 
                405                 410                 415     


Ser Lys Ile Asp Arg Leu Ser Arg Ile Ala Phe Pro Leu Leu Phe Gly 
            420                 425                 430         


Ile Phe Asn Leu Val Tyr Trp Ala Thr Tyr Leu Asn Arg Glu Pro Gln 
        435                 440                 445             


Leu Lys Ala Pro Thr Pro His Gln 
    450                 455     


<210>  3
<211>  451
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Lys Thr Lys Leu Asn Ile Tyr Asn Met Gln Phe Leu Leu Phe Val 
1               5                   10                  15      


Phe Leu Val Trp Asp Pro Ala Arg Leu Val Leu Ala Asn Ile Gln Glu 
            20                  25                  30          


Asp Glu Ala Lys Asn Asn Ile Thr Ile Phe Thr Arg Ile Leu Asp Arg 
        35                  40                  45              


Leu Leu Asp Gly Tyr Asp Asn Arg Leu Arg Pro Gly Leu Gly Asp Ser 
    50                  55                  60                  


Ile Thr Glu Val Phe Thr Asn Ile Tyr Val Thr Ser Phe Gly Pro Val 
65                  70                  75                  80  


Ser Asp Thr Asp Met Glu Tyr Thr Ile Asp Val Phe Phe Arg Gln Lys 
                85                  90                  95      


Trp Lys Asp Glu Arg Leu Lys Phe Lys Gly Pro Met Asn Ile Leu Arg 
            100                 105                 110         


Leu Asn Asn Leu Met Ala Ser Lys Ile Trp Thr Pro Asp Thr Phe Phe 
        115                 120                 125             


His Asn Gly Lys Lys Ser Val Ala His Asn Met Thr Met Pro Asn Lys 
    130                 135                 140                 


Leu Leu Arg Ile Gln Asp Asp Gly Thr Leu Leu Tyr Thr Met Arg Leu 
145                 150                 155                 160 


Thr Val Gln Ala Glu Cys Pro Met His Leu Glu Asp Phe Pro Met Asp 
                165                 170                 175     


Ala His Ser Cys Pro Leu Lys Phe Gly Ser Tyr Ala Tyr Thr Thr Ser 
            180                 185                 190         


Glu Val Thr Tyr Ile Trp Thr Tyr Asn Ala Ser Asp Ser Val Gln Val 
        195                 200                 205             


Ala Pro Asp Gly Ser Arg Leu Asn Gln Tyr Asp Leu Leu Gly Gln Ser 
    210                 215                 220                 


Ile Gly Lys Glu Thr Ile Lys Ser Ser Thr Gly Glu Tyr Thr Val Met 
225                 230                 235                 240 


Thr Ala His Phe His Leu Lys Arg Lys Ile Gly Tyr Phe Val Ile Gln 
                245                 250                 255     


Thr Tyr Leu Pro Cys Ile Met Thr Val Ile Leu Ser Gln Val Ser Phe 
            260                 265                 270         


Trp Leu Asn Arg Glu Ser Val Pro Ala Arg Thr Val Phe Gly Val Thr 
        275                 280                 285             


Thr Val Leu Thr Met Thr Thr Leu Ser Ile Ser Ala Arg Asn Ser Leu 
    290                 295                 300                 


Pro Lys Val Ala Tyr Ala Thr Ala Met Asp Trp Phe Ile Ala Val Cys 
305                 310                 315                 320 


Tyr Ala Phe Val Phe Ser Ala Leu Ile Glu Phe Ala Thr Val Asn Tyr 
                325                 330                 335     


Phe Thr Lys Arg Gly Trp Ala Trp Asp Gly Lys Ser Val Val Asn Asp 
            340                 345                 350         


Lys Lys Lys Glu Lys Ala Ser Val Met Ile Gln Asn Asn Ala Tyr Ala 
        355                 360                 365             


Val Ala Val Ala Asn Tyr Ala Pro Asn Leu Ser Lys Asp Pro Val Leu 
    370                 375                 380                 


Ser Thr Ile Ser Lys Ser Ala Thr Thr Pro Glu Pro Asn Lys Lys Pro 
385                 390                 395                 400 


Glu Asn Lys Pro Ala Glu Ala Lys Lys Thr Phe Asn Ser Val Ser Lys 
                405                 410                 415     


Ile Asp Arg Met Ser Arg Ile Val Phe Pro Val Leu Phe Gly Thr Phe 
            420                 425                 430         


Asn Leu Val Tyr Trp Ala Thr Tyr Leu Asn Arg Glu Pro Val Leu Gly 
        435                 440                 445             


Val Ser Pro 
    450     


<210>  4
<211>  451
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Lys Thr Lys Leu Asn Ile Tyr Asn Met Gln Phe Leu Leu Phe Val 
1               5                   10                  15      


Phe Leu Val Trp Asp Pro Ala Arg Leu Val Leu Ala Asn Ile Gln Glu 
            20                  25                  30          


Asp Glu Ala Lys Asn Asn Ile Thr Ile Phe Thr Arg Ile Leu Asp Arg 
        35                  40                  45              


Leu Leu Asp Gly Tyr Asp Asn Arg Leu Arg Pro Gly Leu Gly Asp Ser 
    50                  55                  60                  


Ile Thr Glu Val Phe Thr Asn Ile Tyr Val Thr Ser Phe Gly Pro Val 
65                  70                  75                  80  


Ser Asp Thr Asp Met Glu Tyr Thr Ile Asp Val Phe Phe Arg Gln Lys 
                85                  90                  95      


Trp Lys Asp Glu Arg Leu Lys Phe Lys Gly Pro Met Asn Ile Leu Arg 
            100                 105                 110         


Leu Asn Asn Leu Met Ala Ser Lys Ile Trp Thr Pro Asp Thr Phe Phe 
        115                 120                 125             


His Asn Gly Lys Lys Ser Val Ala His Asn Met Thr Met Pro Asn Lys 
    130                 135                 140                 


Leu Leu Arg Ile Cys Asp Asp Gly Thr Leu Leu Tyr Thr Met Arg Leu 
145                 150                 155                 160 


Thr Val Gln Ala Glu Cys Pro Met His Leu Glu Asp Phe Pro Met Asp 
                165                 170                 175     


Ala His Ser Cys Pro Leu Lys Phe Gly Ser Tyr Ala Tyr Thr Thr Ser 
            180                 185                 190         


Glu Val Thr Tyr Ile Trp Thr Tyr Asn Ala Ser Asp Ser Val Gln Val 
        195                 200                 205             


Ala Pro Asp Gly Ser Arg Leu Asn Gln Tyr Asp Leu Leu Gly Gln Ser 
    210                 215                 220                 


Ile Gly Lys Glu Thr Ile Lys Ser Ser Thr Gly Glu Tyr Thr Val Met 
225                 230                 235                 240 


Thr Ala His Phe His Leu Lys Arg Lys Ile Gly Tyr Phe Val Ile Gln 
                245                 250                 255     


Thr Tyr Leu Pro Cys Ile Met Thr Val Ile Leu Ser Gln Val Ser Phe 
            260                 265                 270         


Trp Leu Asn Arg Glu Ser Val Pro Ala Arg Thr Val Phe Gly Val Thr 
        275                 280                 285             


Thr Val Leu Thr Met Thr Thr Leu Ser Ile Ser Ala Arg Asn Ser Leu 
    290                 295                 300                 


Pro Lys Val Ala Tyr Ala Thr Ala Met Asp Trp Phe Ile Ala Val Cys 
305                 310                 315                 320 


Tyr Ala Phe Val Phe Ser Ala Leu Ile Glu Phe Ala Thr Val Asn Tyr 
                325                 330                 335     


Phe Thr Lys Arg Gly Trp Ala Trp Asp Gly Lys Ser Val Val Asn Asp 
            340                 345                 350         


Lys Lys Lys Glu Lys Ala Ser Val Met Ile Gln Asn Asn Ala Tyr Ala 
        355                 360                 365             


Val Ala Val Ala Asn Tyr Ala Pro Asn Leu Ser Lys Asp Pro Val Leu 
    370                 375                 380                 


Ser Thr Ile Ser Lys Ser Ala Thr Thr Pro Glu Pro Asn Lys Lys Pro 
385                 390                 395                 400 


Glu Asn Lys Pro Ala Glu Ala Lys Lys Thr Phe Asn Ser Val Ser Lys 
                405                 410                 415     


Ile Asp Arg Met Ser Arg Ile Val Phe Pro Val Leu Phe Gly Thr Phe 
            420                 425                 430         


Asn Leu Val Tyr Trp Ala Thr Tyr Leu Asn Arg Glu Pro Val Leu Gly 
        435                 440                 445             


Val Ser Pro 
    450     


<210>  5
<211>  492
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Ile Ile Thr Gln Thr Ser His Cys Tyr Met Thr Ser Leu Gly Ile 
1               5                   10                  15      


Leu Phe Leu Ile Asn Ile Leu Pro Gly Thr Thr Gly Gln Gly Glu Ser 
            20                  25                  30          


Arg Arg Gln Glu Pro Gly Asp Phe Val Lys Gln Asp Ile Gly Gly Leu 
        35                  40                  45              


Ser Pro Lys His Ala Pro Asp Ile Pro Asp Asp Ser Thr Asp Asn Ile 
    50                  55                  60                  


Thr Ile Phe Thr Arg Ile Leu Asp Arg Leu Leu Asp Gly Tyr Asp Asn 
65                  70                  75                  80  


Arg Leu Arg Pro Gly Leu Gly Asp Ala Val Thr Glu Val Lys Thr Asp 
                85                  90                  95      


Ile Tyr Val Thr Ser Phe Gly Pro Val Ser Asp Thr Asp Met Glu Tyr 
            100                 105                 110         


Thr Ile Asp Val Phe Phe Arg Gln Thr Trp His Asp Glu Arg Leu Lys 
        115                 120                 125             


Phe Asp Gly Pro Met Lys Ile Leu Pro Leu Asn Asn Leu Leu Ala Ser 
    130                 135                 140                 


Lys Ile Trp Thr Pro Asp Thr Phe Phe His Asn Gly Lys Lys Ser Val 
145                 150                 155                 160 


Ala His Asn Met Thr Thr Pro Asn Lys Leu Leu Arg Leu Val Asp Asn 
                165                 170                 175     


Gly Thr Leu Leu Tyr Thr Met Arg Leu Thr Ile His Ala Glu Cys Pro 
            180                 185                 190         


Met His Leu Glu Asp Phe Pro Met Asp Val His Ala Cys Pro Leu Lys 
        195                 200                 205             


Phe Gly Ser Tyr Ala Tyr Thr Thr Ala Glu Val Val Tyr Ser Trp Thr 
    210                 215                 220                 


Leu Gly Lys Asn Lys Ser Val Glu Val Ala Gln Asp Gly Ser Arg Leu 
225                 230                 235                 240 


Asn Gln Tyr Asp Leu Leu Gly His Val Val Gly Thr Glu Ile Ile Arg 
                245                 250                 255     


Ser Ser Thr Gly Glu Tyr Val Val Met Thr Thr His Phe His Leu Lys 
            260                 265                 270         


Arg Lys Ile Gly Tyr Phe Val Ile Gln Thr Tyr Leu Pro Cys Ile Met 
        275                 280                 285             


Thr Val Ile Leu Ser Gln Val Ser Phe Trp Leu Asn Arg Glu Ser Val 
    290                 295                 300                 


Pro Ala Arg Thr Val Phe Gly Val Thr Thr Val Leu Thr Met Thr Thr 
305                 310                 315                 320 


Leu Ser Ile Ser Ala Arg Asn Ser Leu Pro Lys Val Ala Tyr Ala Thr 
                325                 330                 335     


Ala Met Asp Trp Phe Ile Ala Val Cys Tyr Ala Phe Val Phe Ser Ala 
            340                 345                 350         


Leu Ile Glu Phe Ala Thr Val Asn Tyr Phe Thr Lys Arg Ser Trp Ala 
        355                 360                 365             


Trp Glu Gly Lys Lys Val Pro Glu Ala Leu Glu Met Lys Lys Lys Thr 
    370                 375                 380                 


Pro Ala Ala Pro Ala Lys Lys Thr Ser Thr Thr Phe Asn Ile Val Gly 
385                 390                 395                 400 


Thr Thr Tyr Pro Ile Asn Leu Ala Lys Asp Thr Glu Phe Ser Thr Ile 
                405                 410                 415     


Ser Lys Gly Ala Ala Pro Ser Ala Ser Ser Thr Pro Thr Ile Ile Ala 
            420                 425                 430         


Ser Pro Lys Ala Thr Tyr Val Gln Asp Ser Pro Thr Glu Thr Lys Thr 
        435                 440                 445             


Tyr Asn Ser Val Ser Lys Val Asp Lys Ile Ser Arg Ile Ile Phe Pro 
    450                 455                 460                 


Val Leu Phe Ala Ile Phe Asn Leu Val Tyr Trp Ala Thr Tyr Val Asn 
465                 470                 475                 480 


Arg Glu Ser Ala Ile Lys Gly Met Ile Arg Lys Gln 
                485                 490         


<210>  6
<211>  492
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Ile Ile Thr Gln Thr Ser His Cys Tyr Met Thr Ser Leu Gly Ile 
1               5                   10                  15      


Leu Phe Leu Ile Asn Ile Leu Pro Gly Thr Thr Gly Gln Gly Glu Ser 
            20                  25                  30          


Arg Arg Gln Glu Pro Gly Asp Phe Val Lys Gln Asp Ile Gly Gly Leu 
        35                  40                  45              


Ser Pro Lys His Ala Pro Asp Ile Pro Asp Asp Ser Thr Asp Asn Ile 
    50                  55                  60                  


Thr Ile Phe Thr Arg Ile Leu Asp Arg Leu Leu Asp Gly Tyr Asp Asn 
65                  70                  75                  80  


Arg Leu Arg Pro Gly Leu Gly Asp Ala Val Thr Glu Val Lys Thr Asp 
                85                  90                  95      


Ile Tyr Val Thr Ser Phe Gly Pro Val Ser Asp Thr Asp Met Glu Tyr 
            100                 105                 110         


Thr Ile Asp Val Phe Phe Arg Gln Thr Trp His Asp Glu Arg Leu Lys 
        115                 120                 125             


Phe Asp Gly Pro Met Lys Ile Leu Pro Leu Asn Asn Leu Leu Ala Ser 
    130                 135                 140                 


Lys Ile Trp Thr Pro Asp Thr Phe Phe His Asn Gly Lys Lys Ser Val 
145                 150                 155                 160 


Ala His Asn Met Thr Thr Pro Asn Lys Leu Leu Arg Leu Cys Asp Asn 
                165                 170                 175     


Gly Thr Leu Leu Tyr Thr Met Arg Leu Thr Ile His Ala Glu Cys Pro 
            180                 185                 190         


Met His Leu Glu Asp Phe Pro Met Asp Val His Ala Cys Pro Leu Lys 
        195                 200                 205             


Phe Gly Ser Tyr Ala Tyr Thr Thr Ala Glu Val Val Tyr Ser Trp Thr 
    210                 215                 220                 


Leu Gly Lys Asn Lys Ser Val Glu Val Ala Gln Asp Gly Ser Arg Leu 
225                 230                 235                 240 


Asn Gln Tyr Asp Leu Leu Gly His Val Val Gly Thr Glu Ile Ile Arg 
                245                 250                 255     


Ser Ser Thr Gly Glu Tyr Val Val Met Thr Thr His Phe His Leu Lys 
            260                 265                 270         


Arg Lys Ile Gly Tyr Phe Val Ile Gln Thr Tyr Leu Pro Cys Ile Met 
        275                 280                 285             


Thr Val Ile Leu Ser Gln Val Ser Phe Trp Leu Asn Arg Glu Ser Val 
    290                 295                 300                 


Pro Ala Arg Thr Val Phe Gly Val Thr Thr Val Leu Thr Met Thr Thr 
305                 310                 315                 320 


Leu Ser Ile Ser Ala Arg Asn Ser Leu Pro Lys Val Ala Tyr Ala Thr 
                325                 330                 335     


Ala Met Asp Trp Phe Ile Ala Val Cys Tyr Ala Phe Val Phe Ser Ala 
            340                 345                 350         


Leu Ile Glu Phe Ala Thr Val Asn Tyr Phe Thr Lys Arg Ser Trp Ala 
        355                 360                 365             


Trp Glu Gly Lys Lys Val Pro Glu Ala Leu Glu Met Lys Lys Lys Thr 
    370                 375                 380                 


Pro Ala Ala Pro Ala Lys Lys Thr Ser Thr Thr Phe Asn Ile Val Gly 
385                 390                 395                 400 


Thr Thr Tyr Pro Ile Asn Leu Ala Lys Asp Thr Glu Phe Ser Thr Ile 
                405                 410                 415     


Ser Lys Gly Ala Ala Pro Ser Ala Ser Ser Thr Pro Thr Ile Ile Ala 
            420                 425                 430         


Ser Pro Lys Ala Thr Tyr Val Gln Asp Ser Pro Thr Glu Thr Lys Thr 
        435                 440                 445             


Tyr Asn Ser Val Ser Lys Val Asp Lys Ile Ser Arg Ile Ile Phe Pro 
    450                 455                 460                 


Val Leu Phe Ala Ile Phe Asn Leu Val Tyr Trp Ala Thr Tyr Val Asn 
465                 470                 475                 480 


Arg Glu Ser Ala Ile Lys Gly Met Ile Arg Lys Gln 
                485                 490         


<210>  7
<211>  554
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Val Ser Ala Lys Lys Val Pro Ala Ile Ala Leu Ser Ala Gly Val 
1               5                   10                  15      


Ser Phe Ala Leu Leu Arg Phe Leu Cys Leu Ala Val Cys Leu Asn Glu 
            20                  25                  30          


Ser Pro Gly Gln Asn Gln Lys Glu Glu Lys Leu Cys Thr Glu Asn Phe 
        35                  40                  45              


Thr Arg Ile Leu Asp Ser Leu Leu Asp Gly Tyr Asp Asn Arg Leu Arg 
    50                  55                  60                  


Pro Gly Phe Gly Gly Pro Val Thr Glu Val Lys Thr Asp Ile Tyr Val 
65                  70                  75                  80  


Thr Ser Phe Gly Pro Val Ser Asp Val Glu Met Glu Tyr Thr Met Asp 
                85                  90                  95      


Val Phe Phe Arg Gln Thr Trp Ile Asp Lys Arg Leu Lys Tyr Asp Gly 
            100                 105                 110         


Pro Ile Glu Ile Leu Arg Leu Asn Asn Met Met Val Thr Lys Val Trp 
        115                 120                 125             


Thr Pro Asp Thr Phe Phe Arg Asn Gly Lys Lys Ser Val Ser His Asn 
    130                 135                 140                 


Met Thr Ala Pro Asn Lys Leu Phe Arg Ile Met Arg Asn Gly Thr Ile 
145                 150                 155                 160 


Leu Tyr Thr Met Arg Leu Thr Ile Ser Ala Glu Cys Pro Met Arg Leu 
                165                 170                 175     


Val Asp Phe Pro Met Asp Gly His Ala Cys Pro Leu Lys Phe Gly Ser 
            180                 185                 190         


Tyr Ala Tyr Pro Lys Ser Glu Met Ile Tyr Thr Trp Thr Lys Gly Pro 
        195                 200                 205             


Glu Lys Ser Val Glu Val Pro Lys Glu Ser Ser Ser Leu Val Gln Tyr 
    210                 215                 220                 


Asp Leu Ile Gly Gln Thr Val Ser Ser Glu Thr Ile Lys Ser Ile Thr 
225                 230                 235                 240 


Gly Glu Tyr Ile Val Met Thr Val Tyr Phe His Leu Arg Arg Lys Met 
                245                 250                 255     


Gly Tyr Phe Met Ile Gln Thr Tyr Ile Pro Cys Ile Met Thr Val Ile 
            260                 265                 270         


Leu Ser Gln Val Ser Phe Trp Ile Asn Lys Glu Ser Val Pro Ala Arg 
        275                 280                 285             


Thr Val Phe Gly Ile Thr Thr Val Leu Thr Met Thr Thr Leu Ser Ile 
    290                 295                 300                 


Ser Ala Arg His Ser Leu Pro Lys Val Ser Tyr Ala Thr Ala Met Asp 
305                 310                 315                 320 


Trp Phe Ile Ala Val Cys Phe Ala Phe Val Phe Ser Ala Leu Ile Glu 
                325                 330                 335     


Phe Ala Ala Val Asn Tyr Phe Thr Asn Ile Gln Met Glu Lys Ala Lys 
            340                 345                 350         


Arg Lys Thr Ser Lys Pro Pro Gln Glu Val Pro Ala Ala Pro Val Gln 
        355                 360                 365             


Arg Glu Lys His Pro Glu Ala Pro Leu Gln Asn Thr Asn Ala Asn Leu 
    370                 375                 380                 


Asn Met Arg Lys Arg Thr Asn Ala Leu Val His Ser Glu Ser Asp Val 
385                 390                 395                 400 


Gly Asn Arg Thr Glu Val Gly Asn His Ser Ser Lys Ser Ser Thr Val 
                405                 410                 415     


Val Gln Glu Ser Ser Lys Gly Thr Pro Arg Ser Tyr Leu Ala Ser Ser 
            420                 425                 430         


Pro Asn Pro Phe Ser Arg Ala Asn Ala Ala Glu Thr Ile Ser Ala Ala 
        435                 440                 445             


Arg Ala Leu Pro Ser Ala Ser Pro Thr Ser Ile Arg Thr Gly Tyr Met 
    450                 455                 460                 


Pro Arg Lys Ala Ser Val Gly Ser Ala Ser Thr Arg His Val Phe Gly 
465                 470                 475                 480 


Ser Arg Leu Gln Arg Ile Lys Thr Thr Val Asn Thr Ile Gly Ala Thr 
                485                 490                 495     


Gly Lys Leu Ser Ala Thr Pro Pro Pro Ser Ala Pro Pro Pro Ser Gly 
            500                 505                 510         


Ser Gly Thr Ser Lys Ile Asp Lys Tyr Ala Arg Ile Leu Phe Pro Val 
        515                 520                 525             


Thr Phe Gly Ala Phe Asn Met Val Tyr Trp Val Val Tyr Leu Ser Lys 
    530                 535                 540                 


Asp Thr Met Glu Lys Ser Glu Ser Leu Met 
545                 550                 


<210>  8
<211>  554
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Val Ser Ala Lys Lys Val Pro Ala Ile Ala Leu Ser Ala Gly Val 
1               5                   10                  15      


Ser Phe Ala Leu Leu Arg Phe Leu Cys Leu Ala Val Cys Leu Asn Glu 
            20                  25                  30          


Ser Pro Gly Gln Asn Gln Lys Glu Glu Lys Leu Cys Thr Glu Asn Phe 
        35                  40                  45              


Thr Arg Ile Leu Asp Ser Leu Leu Asp Gly Tyr Asp Asn Arg Leu Arg 
    50                  55                  60                  


Pro Gly Phe Gly Gly Pro Val Thr Glu Val Lys Thr Asp Ile Tyr Val 
65                  70                  75                  80  


Thr Ser Phe Gly Pro Val Ser Asp Val Glu Met Glu Tyr Thr Met Asp 
                85                  90                  95      


Val Phe Phe Arg Gln Thr Trp Ile Asp Lys Arg Leu Lys Tyr Asp Gly 
            100                 105                 110         


Pro Ile Glu Ile Leu Arg Leu Asn Asn Met Met Val Thr Lys Val Trp 
        115                 120                 125             


Thr Pro Asp Thr Phe Phe Arg Asn Gly Lys Lys Ser Val Ser His Asn 
    130                 135                 140                 


Met Thr Ala Pro Asn Lys Leu Phe Arg Ile Cys Arg Asn Gly Thr Ile 
145                 150                 155                 160 


Leu Tyr Thr Met Arg Leu Thr Ile Ser Ala Glu Cys Pro Met Arg Leu 
                165                 170                 175     


Val Asp Phe Pro Met Asp Gly His Ala Cys Pro Leu Lys Phe Gly Ser 
            180                 185                 190         


Tyr Ala Tyr Pro Lys Ser Glu Met Ile Tyr Thr Trp Thr Lys Gly Pro 
        195                 200                 205             


Glu Lys Ser Val Glu Val Pro Lys Glu Ser Ser Ser Leu Val Gln Tyr 
    210                 215                 220                 


Asp Leu Ile Gly Gln Thr Val Ser Ser Glu Thr Ile Lys Ser Ile Thr 
225                 230                 235                 240 


Gly Glu Tyr Ile Val Met Thr Val Tyr Phe His Leu Arg Arg Lys Met 
                245                 250                 255     


Gly Tyr Phe Met Ile Gln Thr Tyr Ile Pro Cys Ile Met Thr Val Ile 
            260                 265                 270         


Leu Ser Gln Val Ser Phe Trp Ile Asn Lys Glu Ser Val Pro Ala Arg 
        275                 280                 285             


Thr Val Phe Gly Ile Thr Thr Val Leu Thr Met Thr Thr Leu Ser Ile 
    290                 295                 300                 


Ser Ala Arg His Ser Leu Pro Lys Val Ser Tyr Ala Thr Ala Met Asp 
305                 310                 315                 320 


Trp Phe Ile Ala Val Cys Phe Ala Phe Val Phe Ser Ala Leu Ile Glu 
                325                 330                 335     


Phe Ala Ala Val Asn Tyr Phe Thr Asn Ile Gln Met Glu Lys Ala Lys 
            340                 345                 350         


Arg Lys Thr Ser Lys Pro Pro Gln Glu Val Pro Ala Ala Pro Val Gln 
        355                 360                 365             


Arg Glu Lys His Pro Glu Ala Pro Leu Gln Asn Thr Asn Ala Asn Leu 
    370                 375                 380                 


Asn Met Arg Lys Arg Thr Asn Ala Leu Val His Ser Glu Ser Asp Val 
385                 390                 395                 400 


Gly Asn Arg Thr Glu Val Gly Asn His Ser Ser Lys Ser Ser Thr Val 
                405                 410                 415     


Val Gln Glu Ser Ser Lys Gly Thr Pro Arg Ser Tyr Leu Ala Ser Ser 
            420                 425                 430         


Pro Asn Pro Phe Ser Arg Ala Asn Ala Ala Glu Thr Ile Ser Ala Ala 
        435                 440                 445             


Arg Ala Leu Pro Ser Ala Ser Pro Thr Ser Ile Arg Thr Gly Tyr Met 
    450                 455                 460                 


Pro Arg Lys Ala Ser Val Gly Ser Ala Ser Thr Arg His Val Phe Gly 
465                 470                 475                 480 


Ser Arg Leu Gln Arg Ile Lys Thr Thr Val Asn Thr Ile Gly Ala Thr 
                485                 490                 495     


Gly Lys Leu Ser Ala Thr Pro Pro Pro Ser Ala Pro Pro Pro Ser Gly 
            500                 505                 510         


Ser Gly Thr Ser Lys Ile Asp Lys Tyr Ala Arg Ile Leu Phe Pro Val 
        515                 520                 525             


Thr Phe Gly Ala Phe Asn Met Val Tyr Trp Val Val Tyr Leu Ser Lys 
    530                 535                 540                 


Asp Thr Met Glu Lys Ser Glu Ser Leu Met 
545                 550                 


<210>  9
<211>  462
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Asp Asn Gly Met Phe Ser Gly Phe Ile Met Ile Lys Asn Leu Leu 
1               5                   10                  15      


Leu Phe Cys Ile Ser Met Asn Leu Ser Ser His Phe Gly Phe Ser Gln 
            20                  25                  30          


Met Pro Thr Ser Ser Val Lys Asp Glu Thr Asn Asp Asn Ile Thr Ile 
        35                  40                  45              


Phe Thr Arg Ile Leu Asp Gly Leu Leu Asp Gly Tyr Asp Asn Arg Leu 
    50                  55                  60                  


Arg Pro Gly Leu Gly Glu Arg Ile Thr Gln Val Arg Thr Asp Ile Tyr 
65                  70                  75                  80  


Val Thr Ser Phe Gly Pro Val Ser Asp Thr Glu Met Glu Tyr Thr Ile 
                85                  90                  95      


Asp Val Phe Phe Arg Gln Ser Trp Lys Asp Glu Arg Leu Arg Phe Lys 
            100                 105                 110         


Gly Pro Met Gln Arg Leu Pro Leu Asn Asn Leu Leu Ala Ser Lys Ile 
        115                 120                 125             


Trp Thr Pro Asp Thr Phe Phe His Asn Gly Lys Lys Ser Ile Ala His 
    130                 135                 140                 


Asn Met Thr Thr Pro Asn Lys Leu Leu Arg Leu Glu Asp Asp Gly Thr 
145                 150                 155                 160 


Leu Leu Tyr Thr Met Arg Leu Thr Ile Ser Ala Glu Cys Pro Met Gln 
                165                 170                 175     


Leu Glu Asp Phe Pro Met Asp Ala His Ala Cys Pro Leu Lys Phe Gly 
            180                 185                 190         


Ser Tyr Ala Tyr Pro Asn Ser Glu Val Val Tyr Val Trp Thr Asn Gly 
        195                 200                 205             


Ser Thr Lys Ser Val Val Val Ala Glu Asp Gly Ser Arg Leu Asn Gln 
    210                 215                 220                 


Tyr His Leu Met Gly Gln Thr Val Gly Thr Glu Asn Ile Ser Thr Ser 
225                 230                 235                 240 


Thr Gly Glu Tyr Thr Ile Met Thr Ala His Phe His Leu Lys Arg Lys 
                245                 250                 255     


Ile Gly Tyr Phe Val Ile Gln Thr Tyr Leu Pro Cys Ile Met Thr Val 
            260                 265                 270         


Ile Leu Ser Gln Val Ser Phe Trp Leu Asn Arg Glu Ser Val Pro Ala 
        275                 280                 285             


Arg Thr Val Phe Gly Val Thr Thr Val Leu Thr Met Thr Thr Leu Ser 
    290                 295                 300                 


Ile Ser Ala Arg Asn Ser Leu Pro Lys Val Ala Tyr Ala Thr Ala Met 
305                 310                 315                 320 


Asp Trp Phe Ile Ala Val Cys Tyr Ala Phe Val Phe Ser Ala Leu Ile 
                325                 330                 335     


Glu Phe Ala Thr Val Asn Tyr Phe Thr Lys Arg Gly Trp Ala Trp Asp 
            340                 345                 350         


Gly Lys Lys Ala Leu Glu Ala Ala Lys Ile Lys Lys Lys Arg Glu Val 
        355                 360                 365             


Ile Leu Asn Lys Ser Thr Asn Ala Phe Thr Thr Gly Lys Met Ser His 
    370                 375                 380                 


Pro Pro Asn Ile Pro Lys Glu Gln Thr Pro Ala Gly Thr Ser Asn Thr 
385                 390                 395                 400 


Thr Ser Val Ser Val Lys Pro Ser Glu Glu Lys Thr Ser Glu Ser Lys 
                405                 410                 415     


Lys Thr Tyr Asn Ser Ile Ser Lys Ile Asp Lys Met Ser Arg Ile Val 
            420                 425                 430         


Phe Pro Val Leu Phe Gly Thr Phe Asn Leu Val Tyr Trp Ala Thr Tyr 
        435                 440                 445             


Leu Asn Arg Glu Pro Val Ile Lys Gly Ala Ala Ser Pro Lys 
    450                 455                 460         


<210>  10
<211>  462
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Asp Asn Gly Met Phe Ser Gly Phe Ile Met Ile Lys Asn Leu Leu 
1               5                   10                  15      


Leu Phe Cys Ile Ser Met Asn Leu Ser Ser His Phe Gly Phe Ser Gln 
            20                  25                  30          


Met Pro Thr Ser Ser Val Lys Asp Glu Thr Asn Asp Asn Ile Thr Ile 
        35                  40                  45              


Phe Thr Arg Ile Leu Asp Gly Leu Leu Asp Gly Tyr Asp Asn Arg Leu 
    50                  55                  60                  


Arg Pro Gly Leu Gly Glu Arg Ile Thr Gln Val Arg Thr Asp Ile Tyr 
65                  70                  75                  80  


Val Thr Ser Phe Gly Pro Val Ser Asp Thr Glu Met Glu Tyr Thr Ile 
                85                  90                  95      


Asp Val Phe Phe Arg Gln Ser Trp Lys Asp Glu Arg Leu Arg Phe Lys 
            100                 105                 110         


Gly Pro Met Gln Arg Leu Pro Leu Asn Asn Leu Leu Ala Ser Lys Ile 
        115                 120                 125             


Trp Thr Pro Asp Thr Phe Phe His Asn Gly Lys Lys Ser Ile Ala His 
    130                 135                 140                 


Asn Met Thr Thr Pro Asn Lys Leu Leu Arg Leu Cys Asp Asp Gly Thr 
145                 150                 155                 160 


Leu Leu Tyr Thr Met Arg Leu Thr Ile Ser Ala Glu Cys Pro Met Gln 
                165                 170                 175     


Leu Glu Asp Phe Pro Met Asp Ala His Ala Cys Pro Leu Lys Phe Gly 
            180                 185                 190         


Ser Tyr Ala Tyr Pro Asn Ser Glu Val Val Tyr Val Trp Thr Asn Gly 
        195                 200                 205             


Ser Thr Lys Ser Val Val Val Ala Glu Asp Gly Ser Arg Leu Asn Gln 
    210                 215                 220                 


Tyr His Leu Met Gly Gln Thr Val Gly Thr Glu Asn Ile Ser Thr Ser 
225                 230                 235                 240 


Thr Gly Glu Tyr Thr Ile Met Thr Ala His Phe His Leu Lys Arg Lys 
                245                 250                 255     


Ile Gly Tyr Phe Val Ile Gln Thr Tyr Leu Pro Cys Ile Met Thr Val 
            260                 265                 270         


Ile Leu Ser Gln Val Ser Phe Trp Leu Asn Arg Glu Ser Val Pro Ala 
        275                 280                 285             


Arg Thr Val Phe Gly Val Thr Thr Val Leu Thr Met Thr Thr Leu Ser 
    290                 295                 300                 


Ile Ser Ala Arg Asn Ser Leu Pro Lys Val Ala Tyr Ala Thr Ala Met 
305                 310                 315                 320 


Asp Trp Phe Ile Ala Val Cys Tyr Ala Phe Val Phe Ser Ala Leu Ile 
                325                 330                 335     


Glu Phe Ala Thr Val Asn Tyr Phe Thr Lys Arg Gly Trp Ala Trp Asp 
            340                 345                 350         


Gly Lys Lys Ala Leu Glu Ala Ala Lys Ile Lys Lys Lys Arg Glu Val 
        355                 360                 365             


Ile Leu Asn Lys Ser Thr Asn Ala Phe Thr Thr Gly Lys Met Ser His 
    370                 375                 380                 


Pro Pro Asn Ile Pro Lys Glu Gln Thr Pro Ala Gly Thr Ser Asn Thr 
385                 390                 395                 400 


Thr Ser Val Ser Val Lys Pro Ser Glu Glu Lys Thr Ser Glu Ser Lys 
                405                 410                 415     


Lys Thr Tyr Asn Ser Ile Ser Lys Ile Asp Lys Met Ser Arg Ile Val 
            420                 425                 430         


Phe Pro Val Leu Phe Gly Thr Phe Asn Leu Val Tyr Trp Ala Thr Tyr 
        435                 440                 445             


Leu Asn Arg Glu Pro Val Ile Lys Gly Ala Ala Ser Pro Lys 
    450                 455                 460         


<210>  11
<211>  453
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Ala Ser Ser Leu Pro Trp Leu Cys Ile Ile Leu Trp Leu Glu Asn 
1               5                   10                  15      


Ala Leu Gly Lys Leu Glu Val Glu Gly Asn Phe Tyr Ser Glu Asn Val 
            20                  25                  30          


Ser Arg Ile Leu Asp Asn Leu Leu Glu Gly Tyr Asp Asn Arg Leu Arg 
        35                  40                  45              


Pro Gly Phe Gly Gly Ala Val Thr Glu Val Lys Thr Asp Ile Tyr Val 
    50                  55                  60                  


Thr Ser Phe Gly Pro Val Ser Asp Val Glu Met Glu Tyr Thr Met Asp 
65                  70                  75                  80  


Val Phe Phe Arg Gln Thr Trp Thr Asp Glu Arg Leu Lys Phe Gly Gly 
                85                  90                  95      


Pro Thr Glu Ile Leu Ser Leu Asn Asn Leu Met Val Ser Lys Ile Trp 
            100                 105                 110         


Thr Pro Asp Thr Phe Phe Arg Asn Gly Lys Lys Ser Ile Ala His Asn 
        115                 120                 125             


Met Thr Thr Pro Asn Lys Leu Phe Arg Ile Met Gln Asn Gly Thr Ile 
    130                 135                 140                 


Leu Tyr Thr Met Arg Leu Thr Ile Asn Ala Asp Cys Pro Met Arg Leu 
145                 150                 155                 160 


Val Asn Phe Pro Met Asp Gly His Ala Cys Pro Leu Lys Phe Gly Ser 
                165                 170                 175     


Tyr Ala Tyr Pro Lys Ser Glu Ile Ile Tyr Thr Trp Lys Lys Gly Pro 
            180                 185                 190         


Leu Tyr Ser Val Glu Val Pro Glu Glu Ser Ser Ser Leu Leu Gln Tyr 
        195                 200                 205             


Asp Leu Ile Gly Gln Thr Val Ser Ser Glu Thr Ile Lys Ser Asn Thr 
    210                 215                 220                 


Gly Glu Tyr Val Ile Met Thr Val Tyr Phe His Leu Gln Arg Lys Met 
225                 230                 235                 240 


Gly Tyr Phe Met Ile Gln Ile Tyr Thr Pro Cys Ile Met Thr Val Ile 
                245                 250                 255     


Leu Ser Gln Val Ser Phe Trp Ile Asn Lys Glu Ser Val Pro Ala Arg 
            260                 265                 270         


Thr Val Phe Gly Ile Thr Thr Val Leu Thr Met Thr Thr Leu Ser Ile 
        275                 280                 285             


Ser Ala Arg His Ser Leu Pro Lys Val Ser Tyr Ala Thr Ala Met Asp 
    290                 295                 300                 


Trp Phe Ile Ala Val Cys Phe Ala Phe Val Phe Ser Ala Leu Ile Glu 
305                 310                 315                 320 


Phe Ala Ala Val Asn Tyr Phe Thr Asn Leu Gln Thr Gln Lys Ala Lys 
                325                 330                 335     


Arg Lys Ala Gln Phe Ala Ala Pro Pro Thr Val Thr Ile Ser Lys Ala 
            340                 345                 350         


Thr Glu Pro Leu Glu Ala Glu Ile Val Leu His Pro Asp Ser Lys Tyr 
        355                 360                 365             


His Leu Lys Lys Arg Ile Thr Ser Leu Ser Leu Pro Ile Val Ser Ser 
    370                 375                 380                 


Ser Glu Ala Asn Lys Val Leu Thr Arg Ala Pro Ile Leu Gln Ser Thr 
385                 390                 395                 400 


Pro Val Thr Pro Pro Pro Leu Ser Pro Ala Phe Gly Gly Thr Ser Lys 
                405                 410                 415     


Ile Asp Gln Tyr Ser Arg Ile Leu Phe Pro Val Ala Phe Ala Gly Phe 
            420                 425                 430         


Asn Leu Val Tyr Trp Val Val Tyr Leu Ser Lys Asp Thr Met Glu Val 
        435                 440                 445             


Ser Ser Ser Val Glu 
    450             


<210>  12
<211>  453
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Ala Ser Ser Leu Pro Trp Leu Cys Ile Ile Leu Trp Leu Glu Asn 
1               5                   10                  15      


Ala Leu Gly Lys Leu Glu Val Glu Gly Asn Phe Tyr Ser Glu Asn Val 
            20                  25                  30          


Ser Arg Ile Leu Asp Asn Leu Leu Glu Gly Tyr Asp Asn Arg Leu Arg 
        35                  40                  45              


Pro Gly Phe Gly Gly Ala Val Thr Glu Val Lys Thr Asp Ile Tyr Val 
    50                  55                  60                  


Thr Ser Phe Gly Pro Val Ser Asp Val Glu Met Glu Tyr Thr Met Asp 
65                  70                  75                  80  


Val Phe Phe Arg Gln Thr Trp Thr Asp Glu Arg Leu Lys Phe Gly Gly 
                85                  90                  95      


Pro Thr Glu Ile Leu Ser Leu Asn Asn Leu Met Val Ser Lys Ile Trp 
            100                 105                 110         


Thr Pro Asp Thr Phe Phe Arg Asn Gly Lys Lys Ser Ile Ala His Asn 
        115                 120                 125             


Met Thr Thr Pro Asn Lys Leu Phe Arg Ile Cys Gln Asn Gly Thr Ile 
    130                 135                 140                 


Leu Tyr Thr Met Arg Leu Thr Ile Asn Ala Asp Cys Pro Met Arg Leu 
145                 150                 155                 160 


Val Asn Phe Pro Met Asp Gly His Ala Cys Pro Leu Lys Phe Gly Ser 
                165                 170                 175     


Tyr Ala Tyr Pro Lys Ser Glu Ile Ile Tyr Thr Trp Lys Lys Gly Pro 
            180                 185                 190         


Leu Tyr Ser Val Glu Val Pro Glu Glu Ser Ser Ser Leu Leu Gln Tyr 
        195                 200                 205             


Asp Leu Ile Gly Gln Thr Val Ser Ser Glu Thr Ile Lys Ser Asn Thr 
    210                 215                 220                 


Gly Glu Tyr Val Ile Met Thr Val Tyr Phe His Leu Gln Arg Lys Met 
225                 230                 235                 240 


Gly Tyr Phe Met Ile Gln Ile Tyr Thr Pro Cys Ile Met Thr Val Ile 
                245                 250                 255     


Leu Ser Gln Val Ser Phe Trp Ile Asn Lys Glu Ser Val Pro Ala Arg 
            260                 265                 270         


Thr Val Phe Gly Ile Thr Thr Val Leu Thr Met Thr Thr Leu Ser Ile 
        275                 280                 285             


Ser Ala Arg His Ser Leu Pro Lys Val Ser Tyr Ala Thr Ala Met Asp 
    290                 295                 300                 


Trp Phe Ile Ala Val Cys Phe Ala Phe Val Phe Ser Ala Leu Ile Glu 
305                 310                 315                 320 


Phe Ala Ala Val Asn Tyr Phe Thr Asn Leu Gln Thr Gln Lys Ala Lys 
                325                 330                 335     


Arg Lys Ala Gln Phe Ala Ala Pro Pro Thr Val Thr Ile Ser Lys Ala 
            340                 345                 350         


Thr Glu Pro Leu Glu Ala Glu Ile Val Leu His Pro Asp Ser Lys Tyr 
        355                 360                 365             


His Leu Lys Lys Arg Ile Thr Ser Leu Ser Leu Pro Ile Val Ser Ser 
    370                 375                 380                 


Ser Glu Ala Asn Lys Val Leu Thr Arg Ala Pro Ile Leu Gln Ser Thr 
385                 390                 395                 400 


Pro Val Thr Pro Pro Pro Leu Ser Pro Ala Phe Gly Gly Thr Ser Lys 
                405                 410                 415     


Ile Asp Gln Tyr Ser Arg Ile Leu Phe Pro Val Ala Phe Ala Gly Phe 
            420                 425                 430         


Asn Leu Val Tyr Trp Val Val Tyr Leu Ser Lys Asp Thr Met Glu Val 
        435                 440                 445             


Ser Ser Ser Val Glu 
    450             


<210>  13
<211>  455
<212>  PRT
<213>  Rattus norvegicus

<400>  13

Met Lys Lys Ser Arg Gly Leu Ser Asp Tyr Leu Trp Ala Trp Thr Leu 
1               5                   10                  15      


Ile Leu Ser Thr Leu Ser Gly Arg Ser Tyr Gly Gln Pro Ser Gln Asp 
            20                  25                  30          


Glu Leu Lys Asp Asn Thr Thr Val Phe Thr Arg Ile Leu Asp Arg Leu 
        35                  40                  45              


Leu Asp Gly Tyr Asp Asn Arg Leu Arg Pro Gly Leu Gly Glu Arg Val 
    50                  55                  60                  


Thr Glu Val Lys Thr Asp Ile Phe Val Thr Ser Phe Gly Pro Val Ser 
65                  70                  75                  80  


Asp His Asp Met Glu Tyr Thr Ile Asp Val Phe Phe Arg Gln Ser Trp 
                85                  90                  95      


Lys Asp Glu Arg Leu Lys Phe Lys Gly Pro Met Thr Val Leu Arg Leu 
            100                 105                 110         


Asn Asn Leu Met Ala Ser Lys Ile Trp Thr Pro Asp Thr Phe Phe His 
        115                 120                 125             


Asn Gly Lys Lys Ser Val Ala His Asn Met Thr Met Pro Asn Lys Leu 
    130                 135                 140                 


Leu Arg Ile Thr Glu Asp Gly Thr Leu Leu Tyr Thr Met Arg Leu Thr 
145                 150                 155                 160 


Val Arg Ala Glu Cys Pro Met His Leu Glu Asp Phe Pro Met Asp Ala 
                165                 170                 175     


His Ala Cys Pro Leu Lys Phe Gly Ser Tyr Ala Tyr Thr Arg Ala Glu 
            180                 185                 190         


Val Val Tyr Glu Trp Thr Arg Glu Pro Ala Arg Ser Val Val Val Ala 
        195                 200                 205             


Glu Asp Gly Ser Arg Leu Asn Gln Tyr Asp Leu Leu Gly Gln Thr Val 
    210                 215                 220                 


Asp Ser Gly Ile Val Gln Ser Ser Thr Gly Glu Tyr Val Val Met Thr 
225                 230                 235                 240 


Thr His Phe His Leu Lys Arg Lys Ile Gly Tyr Phe Val Ile Gln Thr 
                245                 250                 255     


Tyr Leu Pro Cys Ile Met Thr Val Ile Leu Ser Gln Val Ser Phe Trp 
            260                 265                 270         


Leu Asn Arg Glu Ser Val Pro Ala Arg Thr Val Phe Gly Val Thr Thr 
        275                 280                 285             


Val Leu Thr Met Thr Thr Leu Ser Ile Ser Ala Arg Asn Ser Leu Pro 
    290                 295                 300                 


Lys Val Ala Tyr Ala Thr Ala Met Asp Trp Phe Ile Ala Val Cys Tyr 
305                 310                 315                 320 


Ala Phe Val Phe Ser Ala Leu Ile Glu Phe Ala Thr Val Asn Tyr Phe 
                325                 330                 335     


Thr Lys Arg Gly Tyr Ala Trp Asp Gly Lys Ser Val Val Pro Glu Lys 
            340                 345                 350         


Pro Lys Lys Val Lys Asp Pro Leu Ile Lys Lys Asn Asn Thr Tyr Ala 
        355                 360                 365             


Pro Thr Ala Thr Ser Tyr Thr Pro Asn Leu Ala Arg Gly Asp Pro Gly 
    370                 375                 380                 


Leu Ala Thr Ile Ala Lys Ser Ala Thr Ile Glu Pro Lys Glu Val Lys 
385                 390                 395                 400 


Pro Glu Thr Lys Pro Pro Glu Pro Lys Lys Thr Phe Asn Ser Val Ser 
                405                 410                 415     


Lys Ile Asp Arg Leu Ser Arg Ile Ala Phe Pro Leu Leu Phe Gly Ile 
            420                 425                 430         


Phe Asn Leu Val Tyr Trp Ala Thr Tyr Leu Asn Arg Glu Pro Gln Leu 
        435                 440                 445             


Lys Ala Pro Thr Pro His Gln 
    450                 455 


<210>  14
<211>  452
<212>  PRT
<213>  Rattus norvegicus

<400>  14

Met Arg Thr Lys Leu Ser Thr Cys Asn Val Trp Phe Pro Leu Leu Val 
1               5                   10                  15      


Leu Leu Val Trp Asn Pro Ala Arg Leu Val Leu Ala Asn Ile Gln Glu 
            20                  25                  30          


Asp Glu Ala Lys Asn Asn Ile Thr Ile Phe Thr Arg Ile Leu Asp Arg 
        35                  40                  45              


Leu Leu Asp Gly Tyr Asp Asn Arg Leu Arg Pro Gly Leu Gly Asp Ser 
    50                  55                  60                  


Ile Thr Glu Val Ser Thr Asn Ile Tyr Val Thr Ser Phe Gly Pro Val 
65                  70                  75                  80  


Ser Asp Thr Asp Met Glu Tyr Thr Ile Asp Val Phe Phe Arg Gln Lys 
                85                  90                  95      


Trp Lys Asp Glu Arg Leu Lys Phe Lys Gly Pro Met Asn Ile Leu Arg 
            100                 105                 110         


Leu Asn Asn Leu Met Ala Ser Lys Ile Trp Thr Pro Asp Thr Phe Phe 
        115                 120                 125             


His Asn Gly Lys Lys Ser Val Ala His Asn Met Thr Met Pro Asn Lys 
    130                 135                 140                 


Leu Leu Arg Ile Gln Asp Asp Gly Thr Leu Leu Tyr Thr Met Arg Leu 
145                 150                 155                 160 


Thr Val Gln Ala Glu Cys Pro Met His Leu Glu Asp Phe Pro Met Asp 
                165                 170                 175     


Ala His Ser Cys Pro Leu Lys Phe Gly Ser Tyr Ala Tyr Thr Thr Ser 
            180                 185                 190         


Glu Val Thr Tyr Ile Trp Thr Tyr Asn Ala Ser Asp Ser Val Gln Val 
        195                 200                 205             


Ala Pro Asp Gly Ser Arg Leu Asn Gln Tyr Asp Leu Leu Gly Gln Ser 
    210                 215                 220                 


Ile Gly Lys Glu Thr Ile Lys Ser Ser Thr Gly Glu Tyr Thr Val Met 
225                 230                 235                 240 


Thr Ala His Phe His Leu Lys Arg Lys Ile Gly Tyr Phe Val Ile Gln 
                245                 250                 255     


Thr Tyr Leu Pro Cys Ile Met Thr Val Ile Leu Ser Gln Val Ser Phe 
            260                 265                 270         


Trp Leu Asn Arg Glu Ser Val Pro Ala Arg Thr Val Phe Gly Val Thr 
        275                 280                 285             


Thr Val Leu Thr Met Thr Thr Leu Ser Ile Ser Ala Arg Asn Ser Leu 
    290                 295                 300                 


Pro Lys Val Ala Tyr Ala Thr Ala Met Asp Trp Phe Ile Ala Val Cys 
305                 310                 315                 320 


Tyr Ala Phe Val Phe Ser Ala Leu Ile Glu Phe Ala Thr Val Asn Tyr 
                325                 330                 335     


Phe Thr Lys Arg Gly Trp Ala Trp Asp Gly Lys Ser Val Val Asn Asp 
            340                 345                 350         


Lys Pro Lys Lys Glu Lys Gly Ser Val Met Ile Gln Asn Asn Ala Tyr 
        355                 360                 365             


Ala Val Ala Val Ala Asn Tyr Ala Pro Asn Leu Ser Lys Asp Pro Val 
    370                 375                 380                 


Leu Ser Thr Ile Ser Lys Ser Ala Thr Thr Pro Glu Pro Asn Lys Lys 
385                 390                 395                 400 


Pro Glu Asn Lys Pro Ala Glu Ala Lys Lys Thr Phe Asn Ser Val Ser 
                405                 410                 415     


Lys Ile Asp Arg Met Ser Arg Ile Val Phe Pro Val Leu Phe Gly Thr 
            420                 425                 430         


Phe Asn Leu Val Tyr Trp Ala Thr Tyr Leu Asn Arg Glu Pro Val Leu 
        435                 440                 445             


Gly Val Ser Pro 
    450         


<210>  15
<211>  493
<212>  PRT
<213>  Rattus norvegicus

<400>  15

Met Ile Thr Thr Gln Met Trp His Phe Tyr Val Thr Arg Val Gly Leu 
1               5                   10                  15      


Leu Leu Leu Ile Ser Ile Leu Pro Gly Thr Thr Gly Gln Gly Glu Ser 
            20                  25                  30          


Arg Arg Gln Glu Pro Gly Asp Phe Val Lys Gln Asp Ile Gly Gly Leu 
        35                  40                  45              


Ser Pro Lys His Ala Pro Asp Ile Pro Asp Asp Ser Thr Asp Asn Ile 
    50                  55                  60                  


Thr Ile Phe Thr Arg Ile Leu Asp Arg Leu Leu Asp Gly Tyr Asp Asn 
65                  70                  75                  80  


Arg Leu Arg Pro Gly Leu Gly Asp Ala Val Thr Glu Val Lys Thr Asp 
                85                  90                  95      


Ile Tyr Val Thr Ser Phe Gly Pro Val Ser Asp Thr Asp Met Glu Tyr 
            100                 105                 110         


Thr Ile Asp Val Phe Phe Arg Gln Thr Trp His Asp Glu Arg Leu Lys 
        115                 120                 125             


Phe Asp Gly Pro Met Lys Ile Leu Pro Leu Asn Asn Leu Leu Ala Ser 
    130                 135                 140                 


Lys Ile Trp Thr Pro Asp Thr Phe Phe His Asn Gly Lys Lys Ser Val 
145                 150                 155                 160 


Ala His Asn Met Thr Thr Pro Asn Lys Leu Leu Arg Leu Val Asp Asn 
                165                 170                 175     


Gly Thr Leu Leu Tyr Thr Met Arg Leu Thr Ile His Ala Glu Cys Pro 
            180                 185                 190         


Met His Leu Glu Asp Phe Pro Met Asp Val His Ala Cys Pro Leu Lys 
        195                 200                 205             


Phe Gly Ser Tyr Ala Tyr Thr Lys Ala Glu Val Ile Tyr Ser Trp Thr 
    210                 215                 220                 


Leu Gly Lys Asn Lys Ser Val Glu Val Ala Gln Asp Gly Ser Arg Leu 
225                 230                 235                 240 


Asn Gln Tyr Asp Leu Leu Gly His Val Val Gly Thr Glu Ile Ile Arg 
                245                 250                 255     


Ser Ser Thr Gly Glu Tyr Val Val Met Thr Thr His Phe His Leu Lys 
            260                 265                 270         


Arg Lys Ile Gly Tyr Phe Val Ile Gln Thr Tyr Leu Pro Cys Ile Met 
        275                 280                 285             


Thr Val Ile Leu Ser Gln Val Ser Phe Trp Leu Asn Arg Glu Ser Val 
    290                 295                 300                 


Pro Ala Arg Thr Val Phe Gly Val Thr Thr Val Leu Thr Met Thr Thr 
305                 310                 315                 320 


Leu Ser Ile Ser Ala Arg Asn Ser Leu Pro Lys Val Ala Tyr Ala Thr 
                325                 330                 335     


Ala Met Asp Trp Phe Ile Ala Val Cys Tyr Ala Phe Val Phe Ser Ala 
            340                 345                 350         


Leu Ile Glu Phe Ala Thr Val Asn Tyr Phe Thr Lys Arg Ser Trp Ala 
        355                 360                 365             


Trp Glu Gly Lys Lys Val Pro Glu Ala Leu Glu Met Lys Lys Lys Thr 
    370                 375                 380                 


Pro Ala Ala Pro Thr Lys Lys Thr Ser Thr Thr Phe Asn Ile Val Gly 
385                 390                 395                 400 


Thr Thr Tyr Pro Ile Asn Leu Ala Lys Asp Thr Glu Phe Ser Thr Ile 
                405                 410                 415     


Ser Lys Ala Ala Ala Ala Pro Ser Ala Ser Ser Thr Pro Thr Val Ile 
            420                 425                 430         


Ala Ser Pro Lys Thr Thr Tyr Val Gln Asp Ser Pro Ala Glu Thr Lys 
        435                 440                 445             


Thr Tyr Asn Ser Val Ser Lys Val Asp Lys Ile Ser Arg Ile Ile Phe 
    450                 455                 460                 


Pro Val Leu Phe Ala Ile Phe Asn Leu Val Tyr Trp Ala Thr Tyr Val 
465                 470                 475                 480 


Asn Arg Glu Ser Ala Ile Lys Gly Met Ile Arg Lys Gln 
                485                 490             


<210>  16
<211>  552
<212>  PRT
<213>  Rattus norvegicus

<400>  16

Met Val Ser Val Gln Lys Val Pro Ala Ile Val Leu Cys Ser Gly Val 
1               5                   10                  15      


Ser Leu Ala Leu Leu His Val Leu Cys Leu Ala Thr Cys Leu Asn Glu 
            20                  25                  30          


Ser Pro Gly Gln Asn Ser Lys Asp Glu Lys Leu Cys Pro Glu Asn Phe 
        35                  40                  45              


Thr Arg Ile Leu Asp Ser Leu Leu Asp Gly Tyr Asp Asn Arg Leu Arg 
    50                  55                  60                  


Pro Gly Phe Gly Gly Pro Val Thr Glu Val Lys Thr Asp Ile Tyr Val 
65                  70                  75                  80  


Thr Ser Phe Gly Pro Val Ser Asp Val Glu Met Glu Tyr Thr Met Asp 
                85                  90                  95      


Val Phe Phe Arg Gln Thr Trp Ile Asp Lys Arg Leu Lys Tyr Asp Gly 
            100                 105                 110         


Pro Ile Glu Ile Leu Arg Leu Asn Asn Met Met Val Thr Lys Val Trp 
        115                 120                 125             


Thr Pro Asp Thr Phe Phe Arg Asn Gly Lys Lys Ser Val Ser His Asn 
    130                 135                 140                 


Met Thr Ala Pro Asn Lys Leu Phe Arg Ile Met Arg Asn Gly Thr Ile 
145                 150                 155                 160 


Leu Tyr Thr Met Arg Leu Thr Ile Ser Ala Glu Cys Pro Met Arg Leu 
                165                 170                 175     


Val Asp Phe Pro Met Asp Gly His Ala Cys Pro Leu Lys Phe Gly Ser 
            180                 185                 190         


Tyr Ala Tyr Pro Lys Ser Glu Met Ile Tyr Thr Trp Thr Lys Gly Pro 
        195                 200                 205             


Glu Lys Ser Val Glu Val Pro Lys Glu Ser Ser Ser Leu Val Gln Tyr 
    210                 215                 220                 


Asp Leu Ile Gly Gln Thr Val Ser Ser Glu Thr Ile Lys Ser Ile Thr 
225                 230                 235                 240 


Gly Glu Tyr Ile Val Met Thr Val Tyr Phe His Leu Arg Arg Lys Met 
                245                 250                 255     


Gly Tyr Phe Met Ile Gln Thr Tyr Ile Pro Cys Ile Met Thr Val Ile 
            260                 265                 270         


Leu Ser Gln Val Ser Phe Trp Ile Asn Lys Glu Ser Val Pro Ala Arg 
        275                 280                 285             


Thr Val Phe Gly Ile Thr Thr Val Leu Thr Met Thr Thr Leu Ser Ile 
    290                 295                 300                 


Ser Ala Arg His Ser Leu Pro Lys Val Ser Tyr Ala Thr Ala Met Asp 
305                 310                 315                 320 


Trp Phe Ile Ala Val Cys Phe Ala Phe Val Phe Ser Ala Leu Ile Glu 
                325                 330                 335     


Phe Ala Ala Val Asn Tyr Phe Thr Asn Ile Gln Met Gln Lys Ala Lys 
            340                 345                 350         


Lys Lys Ile Ser Lys Pro Pro Pro Glu Val Pro Ala Ala Pro Val Leu 
        355                 360                 365             


Lys Glu Lys His Thr Glu Thr Ser Leu Gln Asn Thr His Ala Asn Leu 
    370                 375                 380                 


Asn Met Arg Lys Arg Thr Asn Ala Leu Val His Ser Glu Ser Asp Val 
385                 390                 395                 400 


Asn Ser Arg Thr Glu Val Gly Asn His Ser Ser Lys Thr Thr Ala Ala 
                405                 410                 415     


Gln Glu Ser Ser Glu Thr Thr Pro Lys Ala His Leu Ala Ser Ser Pro 
            420                 425                 430         


Asn Pro Phe Ser Arg Ala Asn Ala Ala Glu Thr Ile Ser Ala Ala Ala 
        435                 440                 445             


Arg Gly Leu Ser Ser Ala Ala Ser Pro Ser Pro His Gly Thr Leu Gln 
    450                 455                 460                 


Pro Ala Pro Leu Arg Ser Ala Ser Ala Arg Pro Ala Phe Gly Ala Arg 
465                 470                 475                 480 


Leu Gly Arg Ile Lys Thr Thr Val Asn Thr Thr Gly Val Pro Gly Asn 
                485                 490                 495     


Val Ser Ala Thr Pro Pro Pro Ser Ala Pro Pro Pro Ser Gly Ser Gly 
            500                 505                 510         


Thr Ser Lys Ile Asp Lys Tyr Ala Arg Ile Leu Phe Pro Val Thr Phe 
        515                 520                 525             


Gly Ala Phe Asn Met Val Tyr Trp Val Val Tyr Leu Ser Lys Asp Thr 
    530                 535                 540                 


Met Glu Lys Ser Glu Ser Leu Met 
545                 550         


<210>  17
<211>  464
<212>  PRT
<213>  Rattus norvegicus

<400>  17

Met Asp Asn Gly Met Leu Ser Arg Phe Ile Met Thr Lys Thr Leu Leu 
1               5                   10                  15      


Val Phe Cys Ile Ser Met Thr Leu Ser Ser His Phe Gly Phe Ser Gln 
            20                  25                  30          


Met Pro Thr Ser Ser Val Gln Asp Glu Thr Asn Asp Asn Ile Thr Ile 
        35                  40                  45              


Phe Thr Arg Ile Leu Asp Gly Leu Leu Asp Gly Tyr Asp Asn Arg Leu 
    50                  55                  60                  


Arg Pro Gly Leu Gly Glu Arg Ile Thr Gln Val Arg Thr Asp Ile Tyr 
65                  70                  75                  80  


Val Thr Ser Phe Gly Pro Val Ser Asp Thr Glu Met Glu Tyr Thr Ile 
                85                  90                  95      


Asp Val Phe Phe Arg Gln Ser Trp Lys Asp Glu Arg Leu Arg Phe Lys 
            100                 105                 110         


Gly Pro Met Gln Arg Leu Pro Leu Asn Asn Leu Leu Ala Arg Lys Ile 
        115                 120                 125             


Trp Thr Pro Asp Thr Phe Phe His Asn Gly Lys Lys Ser Ile Ala His 
    130                 135                 140                 


Asn Met Thr Thr Pro Asn Lys Leu Leu Arg Leu Glu Asp Asp Gly Thr 
145                 150                 155                 160 


Leu Leu Tyr Thr Met Arg Leu Thr Ile Ser Ala Glu Cys Pro Met Gln 
                165                 170                 175     


Leu Glu Asp Phe Pro Met Asp Ala His Ala Cys Pro Leu Lys Phe Gly 
            180                 185                 190         


Ser Tyr Ala Tyr Pro Asn Ser Glu Val Val Tyr Val Trp Thr Asn Gly 
        195                 200                 205             


Ser Thr Lys Ser Val Val Val Ala Glu Asp Gly Ser Arg Leu Asn Gln 
    210                 215                 220                 


Tyr His Leu Met Gly Gln Thr Val Gly Thr Glu Asn Ile Ser Thr Ser 
225                 230                 235                 240 


Thr Gly Glu Tyr Thr Ile Met Thr Ala His Phe His Leu Lys Arg Lys 
                245                 250                 255     


Ile Gly Tyr Phe Val Ile Gln Thr Tyr Leu Pro Cys Ile Met Thr Val 
            260                 265                 270         


Ile Leu Ser Gln Val Ser Phe Trp Leu Asn Arg Glu Ser Val Pro Ala 
        275                 280                 285             


Arg Thr Val Phe Gly Val Thr Thr Val Leu Thr Met Thr Thr Leu Ser 
    290                 295                 300                 


Ile Ser Ala Arg Asn Ser Leu Pro Lys Val Ala Tyr Ala Thr Ala Met 
305                 310                 315                 320 


Asp Trp Phe Ile Ala Val Cys Tyr Ala Phe Val Phe Ser Ala Leu Ile 
                325                 330                 335     


Glu Phe Ala Thr Val Asn Tyr Phe Thr Lys Arg Gly Trp Ala Trp Asp 
            340                 345                 350         


Gly Lys Lys Ala Leu Glu Ala Ala Lys Ile Lys Lys Lys Glu Arg Glu 
        355                 360                 365             


Leu Ile Leu Asn Lys Ser Thr Asn Ala Phe Thr Thr Gly Lys Leu Thr 
    370                 375                 380                 


His Pro Pro Asn Ile Pro Lys Glu Gln Leu Pro Gly Gly Thr Gly Asn 
385                 390                 395                 400 


Ala Val Gly Thr Ala Ser Ile Arg Ala Ser Glu Glu Lys Thr Ser Glu 
                405                 410                 415     


Ser Lys Lys Thr Tyr Asn Ser Ile Ser Lys Ile Asp Lys Met Ser Arg 
            420                 425                 430         


Ile Val Phe Pro Ile Leu Phe Gly Thr Phe Asn Leu Val Tyr Trp Ala 
        435                 440                 445             


Thr Tyr Leu Asn Arg Glu Pro Val Ile Lys Gly Ala Thr Ser Pro Lys 
    450                 455                 460                 


<210>  18
<211>  453
<212>  PRT
<213>  Rattus norvegicus

<400>  18

Met Leu Leu Leu Leu Pro Trp Leu Phe Ser Leu Leu Trp Ile Glu Asn 
1               5                   10                  15      


Ala Gln Ala Gln Leu Glu Asp Glu Gly Asn Phe Tyr Ser Glu Asn Val 
            20                  25                  30          


Ser Arg Ile Leu Asp Asn Leu Leu Glu Gly Tyr Asp Asn Arg Leu Arg 
        35                  40                  45              


Pro Gly Phe Gly Gly Ala Val Thr Glu Val Lys Thr Asp Ile Tyr Val 
    50                  55                  60                  


Thr Ser Phe Gly Pro Val Ser Asp Val Glu Met Glu Tyr Thr Met Asp 
65                  70                  75                  80  


Val Phe Phe Arg Gln Thr Trp Thr Asp Glu Arg Leu Lys Phe Lys Gly 
                85                  90                  95      


Pro Ala Glu Ile Leu Ser Leu Asn Asn Leu Met Val Ser Lys Ile Trp 
            100                 105                 110         


Thr Pro Asp Thr Phe Phe Arg Asn Gly Lys Lys Ser Ile Ala His Asn 
        115                 120                 125             


Met Thr Thr Pro Asn Lys Leu Phe Arg Leu Met His Asn Gly Thr Ile 
    130                 135                 140                 


Leu Tyr Thr Met Arg Leu Thr Ile Asn Ala Asp Cys Pro Met Arg Leu 
145                 150                 155                 160 


Val Asn Phe Pro Met Asp Gly His Ala Cys Pro Leu Lys Phe Gly Ser 
                165                 170                 175     


Tyr Ala Tyr Pro Lys Ser Glu Ile Ile Tyr Thr Trp Lys Lys Gly Pro 
            180                 185                 190         


Leu Tyr Ser Val Glu Val Pro Glu Glu Ser Ser Ser Leu Leu Gln Tyr 
        195                 200                 205             


Asp Leu Ile Gly Gln Thr Val Ser Ser Glu Thr Ile Lys Ser Asn Thr 
    210                 215                 220                 


Gly Glu Tyr Val Ile Met Thr Val Tyr Phe His Leu Gln Arg Lys Met 
225                 230                 235                 240 


Gly Tyr Phe Met Ile Gln Ile Tyr Thr Pro Cys Ile Met Thr Val Ile 
                245                 250                 255     


Leu Ser Gln Val Ser Phe Trp Ile Asn Lys Glu Ser Val Pro Ala Arg 
            260                 265                 270         


Thr Val Phe Gly Ile Thr Thr Val Leu Thr Met Thr Thr Leu Ser Ile 
        275                 280                 285             


Ser Ala Arg His Ser Leu Pro Lys Val Ser Tyr Ala Thr Ala Met Asp 
    290                 295                 300                 


Trp Phe Ile Ala Val Cys Phe Ala Phe Val Phe Ser Ala Leu Ile Glu 
305                 310                 315                 320 


Phe Ala Ala Val Asn Tyr Phe Thr Asn Leu Gln Ser Gln Lys Ala Glu 
                325                 330                 335     


Arg Gln Ala Gln Thr Ala Ala Lys Pro Pro Val Ala Lys Ser Lys Thr 
            340                 345                 350         


Thr Glu Ser Leu Glu Ala Glu Ile Val Val His Ser Asp Ser Lys Tyr 
        355                 360                 365             


His Leu Lys Lys Arg Ile Ser Ser Leu Thr Leu Pro Ile Val Pro Ser 
    370                 375                 380                 


Ser Glu Ala Ser Lys Val Leu Ser Arg Thr Pro Ile Leu Pro Ser Thr 
385                 390                 395                 400 


Pro Val Thr Pro Pro Leu Leu Leu Pro Ala Ile Gly Gly Thr Ser Lys 
                405                 410                 415     


Ile Asp Gln Tyr Ser Arg Ile Leu Phe Pro Val Ala Phe Ala Gly Phe 
            420                 425                 430         


Asn Leu Val Tyr Trp Ile Val Tyr Leu Ser Lys Asp Thr Met Glu Val 
        435                 440                 445             


Ser Ser Thr Val Glu 
    450             


<210>  19
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  19

Leu Leu Arg Ile Thr Glu Asp Gly Thr Leu Leu Tyr Thr 
1               5                   10              


<210>  20
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  20

Leu Leu Arg Ile Gln Asp Asp Gly Thr Leu Leu Tyr Thr 
1               5                   10              


<210>  21
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  21

Leu Leu Arg Leu Val Asp Asn Gly Thr Leu Leu Tyr Thr 
1               5                   10              


<210>  22
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  22

Leu Phe Arg Ile Met Arg Asn Gly Thr Ile Leu Tyr Thr 
1               5                   10              


<210>  23
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  23

Leu Leu Arg Leu Glu Asp Asp Gly Thr Leu Leu Tyr Thr 
1               5                   10              


<210>  24
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  24

Leu Phe Arg Leu Met His Asn Gly Thr Ile Leu Tyr Thr 
1               5                   10              


<210>  25
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  25

Leu Leu Arg Ile Thr Glu Asp Gly Cys Leu Leu Tyr Thr 
1               5                   10              


<210>  26
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  26

Leu Leu Arg Ile Cys Asp Asp Gly Thr Leu Leu Tyr Thr 
1               5                   10              


<210>  27
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  27

Leu Leu Arg Leu Cys Asp Asn Gly Thr Leu Leu Tyr Thr 
1               5                   10              


<210>  28
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  28

Leu Phe Arg Ile Cys Arg Asn Gly Thr Ile Leu Tyr Thr 
1               5                   10              


<210>  29
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  29

Leu Leu Arg Leu Cys Asp Asp Gly Thr Leu Leu Tyr Thr 
1               5                   10              


<210>  30
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  30

Leu Phe Arg Leu Cys His Asn Gly Thr Ile Leu Tyr Thr 
1               5                   10              


