                         SEQUENCE LISTING

<110>  Merck, Sharp & Dohme Corp.
 
<120>  PD1/CTLA4 Binders

<130>  24236

<150>  62/256,985
<151>  2015-11-18

<160>  201   

<170>  PatentIn version 3.5

<210>  1
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized lama

<400>  1

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Ala Ser Ile His 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Val Ile Thr Trp Ser Gly Gly Ile Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Gly Asp Lys His Gln Ser Ser Trp Tyr Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Gln Val Thr Val Ser Ser 
        115                 


<210>  2
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized lama

<400>  2

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Ala Ser Ile His 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Val Ile Thr Trp Ser Gly Gly Ile Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Gly Asp Lys His Gln Ser Ser Trp Tyr Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  3
<211>  5
<212>  PRT
<213>  Lama

<400>  3

Ile His Ala Met Gly 
1               5   


<210>  4
<211>  17
<212>  PRT
<213>  Lama


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  X is W or V

<400>  4

Val Ile Thr Xaa Ser Gly Gly Ile Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  5
<211>  10
<212>  PRT
<213>  Lama


<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  X is W or F

<400>  5

Asp Lys His Gln Ser Ser Xaa Tyr Asp Tyr 
1               5                   10  


<210>  6
<211>  10
<212>  PRT
<213>  Lama

<400>  6

Gly Ser Ile Ala Ser Ile His Ala Met Gly 
1               5                   10  


<210>  7
<211>  10
<212>  PRT
<213>  Lama


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  X is W or V

<400>  7

Val Ile Thr Xaa Ser Gly Gly Ile Thr Tyr 
1               5                   10  


<210>  8
<211>  10
<212>  PRT
<213>  Lama


<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  X is W or F

<400>  8

Asp Lys His Gln Ser Ser Xaa Tyr Asp Tyr 
1               5                   10  


<210>  9
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized lama

<400>  9

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr Phe Ser Phe Tyr 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Gln Glu Phe Val 
        35                  40                  45              


Ala Asp Ile Arg Thr Ser Ala Gly Arg Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Glu Met Ser Gly Ile Ser Gly Trp Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Gln Val Thr Val Ser Ser 
        115                 


<210>  10
<211>  5
<212>  PRT
<213>  Lama

<400>  10

Phe Tyr Gly Met Gly 
1               5   


<210>  11
<211>  17
<212>  PRT
<213>  Lama

<400>  11

Asp Ile Arg Thr Ser Ala Gly Arg Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  12
<211>  10
<212>  PRT
<213>  Lama


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  X is M or P

<400>  12

Glu Xaa Ser Gly Ile Ser Gly Trp Asp Tyr 
1               5                   10  


<210>  13
<211>  10
<212>  PRT
<213>  Lama

<400>  13

Gly Gly Thr Phe Ser Phe Tyr Gly Met Gly 
1               5                   10  


<210>  14
<211>  10
<212>  PRT
<213>  Lama

<400>  14

Asp Ile Arg Thr Ser Ala Gly Arg Thr Tyr 
1               5                   10  


<210>  15
<211>  10
<212>  PRT
<213>  Lama


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  X is M or P

<400>  15

Glu Xaa Ser Gly Ile Ser Gly Trp Asp Tyr 
1               5                   10  


<210>  16
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized lama

<400>  16

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Ala Ser Ile His 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Val Ile Thr Trp Ser Gly Gly Ile Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Gly Asp Lys His Gln Ser Ser Trp Tyr Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  17
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized lama

<400>  17

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Ala Ser Ile His 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Val Ile Thr Trp Ser Gly Gly Ile Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Gly Asp Lys His Gln Ser Ser Trp Tyr Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Lys Val Ser Ser 
        115                 


<210>  18
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized lama

<400>  18

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Ala Ser Ile His 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Val Ile Thr Trp Ser Gly Gly Ile Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Gly Asp Lys His Gln Ser Ser Trp Tyr Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Gln Val Ser Ser 
        115                 


<210>  19
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized lama

<400>  19

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Ala Ser Ile His 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Val Ile Thr Trp Ser Gly Gly Ile Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Gly Asp Lys His Gln Ser Ser Trp Tyr Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Lys Ser 
        115                 


<210>  20
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized lama

<400>  20

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Ala Ser Ile His 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Val Ile Thr Trp Ser Gly Gly Ile Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Gly Asp Lys His Gln Ser Ser Trp Tyr Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Gln Ser 
        115                 


<210>  21
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized lama

<400>  21

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Ala Ser Ile His 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Val Ile Thr Trp Ser Gly Gly Ile Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Gly Asp Lys His Gln Ser Ser Trp Tyr Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Lys Val Ser Ser 
        115                 


<210>  22
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized lama

<400>  22

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Ala Ser Ile His 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Val Ile Thr Trp Ser Gly Gly Ile Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Gly Asp Lys His Gln Ser Ser Trp Tyr Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Gln Val Ser Ser 
        115                 


<210>  23
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized lama

<400>  23

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Ala Ser Ile His 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Val Ile Thr Trp Ser Gly Gly Ile Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Gly Asp Lys His Gln Ser Ser Trp Tyr Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Lys Ser 
        115                 


<210>  24
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized lama

<400>  24

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Ala Ser Ile His 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Val Ile Thr Trp Ser Gly Gly Ile Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Gly Asp Lys His Gln Ser Ser Trp Tyr Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Gln Ser 
        115                 


<210>  25
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized lama

<400>  25

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Ala Ser Ile His 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Val Ile Thr Trp Ser Gly Gly Ile Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Gly Asp Lys His Gln Ser Ser Trp Tyr Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  26
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized lama

<400>  26

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Ala Ser Ile His 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Val Ile Thr Trp Ser Gly Gly Ile Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Gly Asp Lys His Gln Ser Ser Trp Tyr Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Lys Val Ser Ser 
        115                 


<210>  27
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized lama

<400>  27

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Ala Ser Ile His 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Val Ile Thr Trp Ser Gly Gly Ile Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Gly Asp Lys His Gln Ser Ser Trp Tyr Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Gln Val Ser Ser 
        115                 


<210>  28
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized lama

<400>  28

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Ala Ser Ile His 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Val Ile Thr Trp Ser Gly Gly Ile Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Gly Asp Lys His Gln Ser Ser Trp Tyr Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Lys Ser 
        115                 


<210>  29
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized lama

<400>  29

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Ala Ser Ile His 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Val Ile Thr Trp Ser Gly Gly Ile Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Gly Asp Lys His Gln Ser Ser Trp Tyr Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Gln Ser 
        115                 


<210>  30
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized lama

<400>  30

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Ala Ser Ile His 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Val Ile Thr Trp Ser Gly Gly Ile Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Gly Asp Lys His Gln Ser Ser Trp Tyr Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  31
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized lama

<400>  31

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Ala Ser Ile His 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Val Ile Thr Trp Ser Gly Gly Ile Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Gly Asp Lys His Gln Ser Ser Trp Tyr Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  32
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized lama

<400>  32

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Ala Ser Ile His 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Val Ile Thr Trp Ser Gly Gly Ile Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Gly Asp Lys His Gln Ser Ser Trp Tyr Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala 
        115                 120 


<210>  33
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized lama

<400>  33

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Ala Ser Ile His 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Val Ile Thr Trp Ser Gly Gly Ile Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Gly Asp Lys His Gln Ser Ser Trp Tyr Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Lys Val Ser Ser Ala 
        115                 120 


<210>  34
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized lama

<400>  34

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Ala Ser Ile His 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Val Ile Thr Trp Ser Gly Gly Ile Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Gly Asp Lys His Gln Ser Ser Trp Tyr Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Gln Val Ser Ser Ala 
        115                 120 


<210>  35
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized lama

<400>  35

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Ala Ser Ile His 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Val Ile Thr Trp Ser Gly Gly Ile Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Gly Asp Lys His Gln Ser Ser Trp Tyr Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Lys Ser Ala 
        115                 120 


<210>  36
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized lama

<400>  36

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Ala Ser Ile His 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Val Ile Thr Trp Ser Gly Gly Ile Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Gly Asp Lys His Gln Ser Ser Trp Tyr Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Gln Ser Ala 
        115                 120 


<210>  37
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized lama

<400>  37

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Ala Ser Ile His 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Val Ile Thr Trp Ser Gly Gly Ile Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Gly Asp Lys His Gln Ser Ser Trp Tyr Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Lys Val Ser Ser Ala 
        115                 120 


<210>  38
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized lama

<400>  38

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Ala Ser Ile His 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Val Ile Thr Trp Ser Gly Gly Ile Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Gly Asp Lys His Gln Ser Ser Trp Tyr Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Gln Val Ser Ser Ala 
        115                 120 


<210>  39
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized lama

<400>  39

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Ala Ser Ile His 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Val Ile Thr Trp Ser Gly Gly Ile Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Gly Asp Lys His Gln Ser Ser Trp Tyr Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Lys Ser Ala 
        115                 120 


<210>  40
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized lama

<400>  40

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Ala Ser Ile His 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Val Ile Thr Trp Ser Gly Gly Ile Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Gly Asp Lys His Gln Ser Ser Trp Tyr Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Gln Ser Ala 
        115                 120 


<210>  41
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized lama

<400>  41

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Ala Ser Ile His 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Val Ile Thr Trp Ser Gly Gly Ile Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Gly Asp Lys His Gln Ser Ser Trp Tyr Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala 
        115                 120 


<210>  42
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized lama

<400>  42

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Ala Ser Ile His 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Val Ile Thr Trp Ser Gly Gly Ile Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Gly Asp Lys His Gln Ser Ser Trp Tyr Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Lys Val Ser Ser Ala 
        115                 120 


<210>  43
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized lama

<400>  43

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Ala Ser Ile His 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Val Ile Thr Trp Ser Gly Gly Ile Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Gly Asp Lys His Gln Ser Ser Trp Tyr Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Gln Val Ser Ser Ala 
        115                 120 


<210>  44
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized lama

<400>  44

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Ala Ser Ile His 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Val Ile Thr Trp Ser Gly Gly Ile Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Gly Asp Lys His Gln Ser Ser Trp Tyr Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Lys Ser Ala 
        115                 120 


<210>  45
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized lama

<400>  45

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Ala Ser Ile His 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Val Ile Thr Trp Ser Gly Gly Ile Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Gly Asp Lys His Gln Ser Ser Trp Tyr Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Gln Ser Ala 
        115                 120 


<210>  46
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized lama

<400>  46

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Ala Ser Ile His 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Val Ile Thr Trp Ser Gly Gly Ile Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Gly Asp Lys His Gln Ser Ser Trp Tyr Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala 
        115                 120 


<210>  47
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized lama

<400>  47

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Ala Ser Ile His 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Val Ile Thr Trp Ser Gly Gly Ile Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Gly Asp Lys His Gln Ser Ser Trp Tyr Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala 
        115                 120 


<210>  48
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized lama

<400>  48

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr Phe Ser Phe Tyr 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Gln Glu Phe Val 
        35                  40                  45              


Ala Asp Ile Arg Thr Ser Ala Gly Arg Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Glu Met Ser Gly Ile Ser Gly Trp Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Gln Val Thr Val Ser Ser 
        115                 


<210>  49
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized lama

<400>  49

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr Phe Ser Phe Tyr 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Gln Glu Phe Val 
        35                  40                  45              


Ala Asp Ile Arg Thr Ser Ala Gly Arg Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Glu Met Ser Gly Ile Ser Gly Trp Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Gln Val Lys Val Ser Ser 
        115                 


<210>  50
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized lama

<400>  50

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr Phe Ser Phe Tyr 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Gln Glu Phe Val 
        35                  40                  45              


Ala Asp Ile Arg Thr Ser Ala Gly Arg Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Glu Met Ser Gly Ile Ser Gly Trp Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Gln Val Gln Val Ser Ser 
        115                 


<210>  51
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized lama

<400>  51

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr Phe Ser Phe Tyr 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Gln Glu Phe Val 
        35                  40                  45              


Ala Asp Ile Arg Thr Ser Ala Gly Arg Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Glu Met Ser Gly Ile Ser Gly Trp Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Gln Val Thr Val Lys Ser 
        115                 


<210>  52
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized lama

<400>  52

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr Phe Ser Phe Tyr 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Gln Glu Phe Val 
        35                  40                  45              


Ala Asp Ile Arg Thr Ser Ala Gly Arg Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Glu Met Ser Gly Ile Ser Gly Trp Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Gln Val Thr Val Gln Ser 
        115                 


<210>  53
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized lama

<400>  53

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr Phe Ser Phe Tyr 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Gln Glu Phe Val 
        35                  40                  45              


Ala Asp Ile Arg Thr Ser Ala Gly Arg Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Glu Met Ser Gly Ile Ser Gly Trp Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Gln Val Lys Val Ser Ser 
        115                 


<210>  54
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized lama

<400>  54

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr Phe Ser Phe Tyr 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Gln Glu Phe Val 
        35                  40                  45              


Ala Asp Ile Arg Thr Ser Ala Gly Arg Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Glu Met Ser Gly Ile Ser Gly Trp Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Gln Val Gln Val Ser Ser 
        115                 


<210>  55
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized lama

<400>  55

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr Phe Ser Phe Tyr 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Gln Glu Phe Val 
        35                  40                  45              


Ala Asp Ile Arg Thr Ser Ala Gly Arg Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Glu Met Ser Gly Ile Ser Gly Trp Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Gln Val Thr Val Lys Ser 
        115                 


<210>  56
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized lama

<400>  56

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr Phe Ser Phe Tyr 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Gln Glu Phe Val 
        35                  40                  45              


Ala Asp Ile Arg Thr Ser Ala Gly Arg Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Glu Met Ser Gly Ile Ser Gly Trp Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Gln Val Thr Val Gln Ser 
        115                 


<210>  57
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized lama

<400>  57

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr Phe Ser Phe Tyr 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Gln Glu Phe Val 
        35                  40                  45              


Ala Asp Ile Arg Thr Ser Ala Gly Arg Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Glu Met Ser Gly Ile Ser Gly Trp Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Gln Val Thr Val Ser Ser 
        115                 


<210>  58
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized lama

<400>  58

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr Phe Ser Phe Tyr 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Gln Glu Phe Val 
        35                  40                  45              


Ala Asp Ile Arg Thr Ser Ala Gly Arg Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Glu Met Ser Gly Ile Ser Gly Trp Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Gln Val Lys Val Ser Ser 
        115                 


<210>  59
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized lama

<400>  59

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr Phe Ser Phe Tyr 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Gln Glu Phe Val 
        35                  40                  45              


Ala Asp Ile Arg Thr Ser Ala Gly Arg Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Glu Met Ser Gly Ile Ser Gly Trp Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Gln Val Gln Val Ser Ser 
        115                 


<210>  60
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized lama

<400>  60

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr Phe Ser Phe Tyr 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Gln Glu Phe Val 
        35                  40                  45              


Ala Asp Ile Arg Thr Ser Ala Gly Arg Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Glu Met Ser Gly Ile Ser Gly Trp Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Gln Val Thr Val Lys Ser 
        115                 


<210>  61
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized lama

<400>  61

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr Phe Ser Phe Tyr 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Gln Glu Phe Val 
        35                  40                  45              


Ala Asp Ile Arg Thr Ser Ala Gly Arg Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Glu Met Ser Gly Ile Ser Gly Trp Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Gln Val Thr Val Gln Ser 
        115                 


<210>  62
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized lama

<400>  62

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr Phe Ser Phe Tyr 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Gln Glu Phe Val 
        35                  40                  45              


Ala Asp Ile Arg Thr Ser Ala Gly Arg Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Glu Met Ser Gly Ile Ser Gly Trp Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  63
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized lama

<400>  63

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr Phe Ser Phe Tyr 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Asp Ile Arg Thr Ser Ala Gly Arg Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Glu Met Ser Gly Ile Ser Gly Trp Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  64
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized lama

<400>  64

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr Phe Ser Phe Tyr 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Gln Glu Phe Val 
        35                  40                  45              


Ala Asp Ile Arg Thr Ser Ala Gly Arg Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Glu Met Ser Gly Ile Ser Gly Trp Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  65
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized lama

<400>  65

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr Phe Ser Phe Tyr 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Asp Ile Arg Thr Ser Ala Gly Arg Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Glu Met Ser Gly Ile Ser Gly Trp Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  66
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized lama

<400>  66

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr Phe Ser Phe Tyr 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Gln Glu Phe Val 
        35                  40                  45              


Ala Asp Ile Arg Thr Ser Ala Gly Arg Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Glu Met Ser Gly Ile Ser Gly Trp Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Gln Val Thr Val Ser Ser Ala 
        115                 120 


<210>  67
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized lama

<400>  67

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr Phe Ser Phe Tyr 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Gln Glu Phe Val 
        35                  40                  45              


Ala Asp Ile Arg Thr Ser Ala Gly Arg Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Glu Met Ser Gly Ile Ser Gly Trp Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Gln Val Lys Val Ser Ser Ala 
        115                 120 


<210>  68
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized lama

<400>  68

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr Phe Ser Phe Tyr 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Gln Glu Phe Val 
        35                  40                  45              


Ala Asp Ile Arg Thr Ser Ala Gly Arg Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Glu Met Ser Gly Ile Ser Gly Trp Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Gln Val Gln Val Ser Ser Ala 
        115                 120 


<210>  69
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized lama

<400>  69

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr Phe Ser Phe Tyr 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Gln Glu Phe Val 
        35                  40                  45              


Ala Asp Ile Arg Thr Ser Ala Gly Arg Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Glu Met Ser Gly Ile Ser Gly Trp Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Gln Val Thr Val Lys Ser Ala 
        115                 120 


<210>  70
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized lama

<400>  70

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr Phe Ser Phe Tyr 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Gln Glu Phe Val 
        35                  40                  45              


Ala Asp Ile Arg Thr Ser Ala Gly Arg Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Glu Met Ser Gly Ile Ser Gly Trp Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Gln Val Thr Val Gln Ser Ala 
        115                 120 


<210>  71
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized lama

<400>  71

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr Phe Ser Phe Tyr 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Gln Glu Phe Val 
        35                  40                  45              


Ala Asp Ile Arg Thr Ser Ala Gly Arg Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Glu Met Ser Gly Ile Ser Gly Trp Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Gln Val Lys Val Ser Ser Ala 
        115                 120 


<210>  72
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized lama

<400>  72

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr Phe Ser Phe Tyr 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Gln Glu Phe Val 
        35                  40                  45              


Ala Asp Ile Arg Thr Ser Ala Gly Arg Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Glu Met Ser Gly Ile Ser Gly Trp Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Gln Val Gln Val Ser Ser Ala 
        115                 120 


<210>  73
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized lama

<400>  73

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr Phe Ser Phe Tyr 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Gln Glu Phe Val 
        35                  40                  45              


Ala Asp Ile Arg Thr Ser Ala Gly Arg Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Glu Met Ser Gly Ile Ser Gly Trp Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Gln Val Thr Val Lys Ser Ala 
        115                 120 


<210>  74
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized lama

<400>  74

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr Phe Ser Phe Tyr 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Gln Glu Phe Val 
        35                  40                  45              


Ala Asp Ile Arg Thr Ser Ala Gly Arg Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Glu Met Ser Gly Ile Ser Gly Trp Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Gln Val Thr Val Gln Ser Ala 
        115                 120 


<210>  75
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized lama

<400>  75

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr Phe Ser Phe Tyr 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Gln Glu Phe Val 
        35                  40                  45              


Ala Asp Ile Arg Thr Ser Ala Gly Arg Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Glu Met Ser Gly Ile Ser Gly Trp Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Gln Val Thr Val Ser Ser Ala 
        115                 120 


<210>  76
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized lama

<400>  76

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr Phe Ser Phe Tyr 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Gln Glu Phe Val 
        35                  40                  45              


Ala Asp Ile Arg Thr Ser Ala Gly Arg Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Glu Met Ser Gly Ile Ser Gly Trp Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Gln Val Lys Val Ser Ser Ala 
        115                 120 


<210>  77
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized lama

<400>  77

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr Phe Ser Phe Tyr 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Gln Glu Phe Val 
        35                  40                  45              


Ala Asp Ile Arg Thr Ser Ala Gly Arg Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Glu Met Ser Gly Ile Ser Gly Trp Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Gln Val Gln Val Ser Ser Ala 
        115                 120 


<210>  78
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized lama

<400>  78

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr Phe Ser Phe Tyr 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Gln Glu Phe Val 
        35                  40                  45              


Ala Asp Ile Arg Thr Ser Ala Gly Arg Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Glu Met Ser Gly Ile Ser Gly Trp Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Gln Val Thr Val Lys Ser Ala 
        115                 120 


<210>  79
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized lama

<400>  79

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr Phe Ser Phe Tyr 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Gln Glu Phe Val 
        35                  40                  45              


Ala Asp Ile Arg Thr Ser Ala Gly Arg Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Glu Met Ser Gly Ile Ser Gly Trp Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Gln Val Thr Val Gln Ser Ala 
        115                 120 


<210>  80
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized lama

<400>  80

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr Phe Ser Phe Tyr 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Gln Glu Phe Val 
        35                  40                  45              


Ala Asp Ile Arg Thr Ser Ala Gly Arg Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Glu Met Ser Gly Ile Ser Gly Trp Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala 
        115                 120 


<210>  81
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized lama

<400>  81

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr Phe Ser Phe Tyr 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Asp Ile Arg Thr Ser Ala Gly Arg Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Glu Met Ser Gly Ile Ser Gly Trp Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala 
        115                 120 


<210>  82
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized lama

<400>  82

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr Phe Ser Phe Tyr 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Gln Glu Phe Val 
        35                  40                  45              


Ala Asp Ile Arg Thr Ser Ala Gly Arg Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Glu Met Ser Gly Ile Ser Gly Trp Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala 
        115                 120 


<210>  83
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized lama

<400>  83

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr Phe Ser Phe Tyr 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Asp Ile Arg Thr Ser Ala Gly Arg Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Glu Met Ser Gly Ile Ser Gly Trp Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala 
        115                 120 


<210>  84
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized lama

<400>  84

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Asn 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  85
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized lama

<400>  85

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Ser Phe 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  86
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  35GS linker

<400>  86

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            20                  25                  30          


Gly Gly Ser 
        35  


<210>  87
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  His6-FLAG3 tag

<400>  87

His His His His His His Gly Ala Ala Asp Tyr Lys Asp His Asp Gly 
1               5                   10                  15      


Asp Tyr Lys Asp His Asp Ile Asp Tyr Lys Asp Asp Asp Asp Lys Gly 
            20                  25                  30          


Ala Ala 
        


<210>  88
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-terminal extender

<400>  88

Val Thr Val Lys Ser 
1               5   


<210>  89
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-terminal extender

<400>  89

Val Thr Val Gln Ser 
1               5   


<210>  90
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-terminal extender

<400>  90

Val Lys Val Ser Ser 
1               5   


<210>  91
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-terminal extender

<400>  91

Val Gln Val Ser Ser 
1               5   


<210>  92
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-terminal extender


<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  X is 1-10 amino acids independently chosen from the naturally 
       occurring amino acids

<400>  92

Val Thr Val Lys Ser Xaa 
1               5       


<210>  93
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-terminal extender


<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  X is 1-10 amino acids independently chosen from the naturally 
       occurring amino acids

<400>  93

Val Thr Val Gln Ser Xaa 
1               5       


<210>  94
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-terminal extender


<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  X is 1-10 amino acids independently chosen from the naturally 
       occurring amino acids

<400>  94

Val Lys Val Ser Ser Xaa 
1               5       


<210>  95
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-terminal extender


<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  X is 1-10 amino acids independently chosen from the naturally 
       occurring amino acids

<400>  95

Val Gln Val Ser Ser Xaa 
1               5       


<210>  96
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-terminal extender

<400>  96

Val Thr Val Lys Ser Ala 
1               5       


<210>  97
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-terminal extender

<400>  97

Val Thr Val Gln Ser Ala 
1               5       


<210>  98
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-terminal extender

<400>  98

Val Lys Val Ser Ser Ala 
1               5       


<210>  99
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-terminal extender

<400>  99

Val Gln Val Ser Ser Ala 
1               5       


<210>  100
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-terminal extender

<400>  100

Val Thr Val Ser Ser 
1               5   


<210>  101
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-terminal extender


<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  X is 1-10 amino acids independently chosen from the naturally 
       occurring amino acids

<400>  101

Val Thr Val Ser Ser Xaa 
1               5       


<210>  102
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-terminal extender

<400>  102

Val Thr Val Ser Ser Ala 
1               5       


<210>  103
<211>  732
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized lama

<400>  103

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Ala Ser Ile His 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Val Ile Thr Trp Ser Gly Gly Ile Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Gly Asp Lys His Gln Ser Ser Trp Tyr Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu 
145                 150                 155                 160 


Ser Gly Gly Gly Val Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
                165                 170                 175     


Ala Ala Ser Gly Ser Ile Ala Ser Ile His Ala Met Gly Trp Phe Arg 
            180                 185                 190         


Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ala Val Ile Thr Trp Ser 
        195                 200                 205             


Gly Gly Ile Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
    210                 215                 220                 


Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu 
225                 230                 235                 240 


Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Ala Gly Asp Lys His Gln 
                245                 250                 255     


Ser Ser Trp Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            260                 265                 270         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        275                 280                 285             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    290                 295                 300                 


Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val 
305                 310                 315                 320 


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr 
                325                 330                 335     


Phe Ser Phe Tyr Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu 
            340                 345                 350         


Gln Glu Phe Val Ala Asp Ile Arg Thr Ser Ala Gly Arg Thr Tyr Tyr 
        355                 360                 365             


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys 
    370                 375                 380                 


Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala 
385                 390                 395                 400 


Leu Tyr Tyr Cys Ala Ala Glu Met Ser Gly Ile Ser Gly Trp Asp Tyr 
                405                 410                 415     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
            420                 425                 430         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        435                 440                 445             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
    450                 455                 460                 


Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly Ser Leu 
465                 470                 475                 480 


Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr Phe Ser Phe Tyr Gly Met 
                485                 490                 495     


Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Gln Glu Phe Val Ala Asp 
            500                 505                 510         


Ile Arg Thr Ser Ala Gly Arg Thr Tyr Tyr Ala Asp Ser Val Lys Gly 
        515                 520                 525             


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu Gln 
    530                 535                 540                 


Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Ala Ala 
545                 550                 555                 560 


Glu Met Ser Gly Ile Ser Gly Trp Asp Tyr Trp Gly Gln Gly Thr Leu 
                565                 570                 575     


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
            580                 585                 590         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        595                 600                 605             


Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly 
    610                 615                 620                 


Gly Gly Leu Val Gln Pro Gly Asn Ser Leu Arg Leu Ser Cys Ala Ala 
625                 630                 635                 640 


Ser Gly Phe Thr Phe Ser Ser Phe Gly Met Ser Trp Val Arg Gln Ala 
                645                 650                 655     


Pro Gly Lys Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Ser 
            660                 665                 670         


Asp Thr Leu Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
        675                 680                 685             


Asp Asn Ala Lys Thr Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro 
    690                 695                 700                 


Glu Asp Thr Ala Val Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser Arg 
705                 710                 715                 720 


Ser Ser Gln Gly Thr Leu Val Thr Val Ser Ser Ala 
                725                 730         


<210>  104
<211>  732
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized lama

<400>  104

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Ala Ser Ile His 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Val Ile Thr Trp Ser Gly Gly Ile Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Gly Asp Lys His Gln Ser Ser Trp Tyr Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu 
145                 150                 155                 160 


Ser Gly Gly Gly Val Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
                165                 170                 175     


Ala Ala Ser Gly Ser Ile Ala Ser Ile His Ala Met Gly Trp Phe Arg 
            180                 185                 190         


Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ala Val Ile Thr Trp Ser 
        195                 200                 205             


Gly Gly Ile Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
    210                 215                 220                 


Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu 
225                 230                 235                 240 


Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Ala Gly Asp Lys His Gln 
                245                 250                 255     


Ser Ser Trp Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            260                 265                 270         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        275                 280                 285             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    290                 295                 300                 


Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val 
305                 310                 315                 320 


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr 
                325                 330                 335     


Phe Ser Phe Tyr Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu 
            340                 345                 350         


Arg Glu Phe Val Ala Asp Ile Arg Thr Ser Ala Gly Arg Thr Tyr Tyr 
        355                 360                 365             


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys 
    370                 375                 380                 


Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala 
385                 390                 395                 400 


Leu Tyr Tyr Cys Ala Ala Glu Met Ser Gly Ile Ser Gly Trp Asp Tyr 
                405                 410                 415     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
            420                 425                 430         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        435                 440                 445             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
    450                 455                 460                 


Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly Ser Leu 
465                 470                 475                 480 


Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr Phe Ser Phe Tyr Gly Met 
                485                 490                 495     


Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ala Asp 
            500                 505                 510         


Ile Arg Thr Ser Ala Gly Arg Thr Tyr Tyr Ala Asp Ser Val Lys Gly 
        515                 520                 525             


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu Gln 
    530                 535                 540                 


Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Ala Ala 
545                 550                 555                 560 


Glu Met Ser Gly Ile Ser Gly Trp Asp Tyr Trp Gly Gln Gly Thr Leu 
                565                 570                 575     


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
            580                 585                 590         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        595                 600                 605             


Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly 
    610                 615                 620                 


Gly Gly Leu Val Gln Pro Gly Asn Ser Leu Arg Leu Ser Cys Ala Ala 
625                 630                 635                 640 


Ser Gly Phe Thr Phe Ser Ser Phe Gly Met Ser Trp Val Arg Gln Ala 
                645                 650                 655     


Pro Gly Lys Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Ser 
            660                 665                 670         


Asp Thr Leu Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
        675                 680                 685             


Asp Asn Ala Lys Thr Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro 
    690                 695                 700                 


Glu Asp Thr Ala Val Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser Arg 
705                 710                 715                 720 


Ser Ser Gln Gly Thr Leu Val Thr Val Ser Ser Ala 
                725                 730         


<210>  105
<211>  732
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized lama

<400>  105

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Ala Ser Ile His 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Val Ile Thr Trp Ser Gly Gly Ile Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Gly Asp Lys His Gln Ser Ser Trp Tyr Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu 
145                 150                 155                 160 


Ser Gly Gly Gly Val Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
                165                 170                 175     


Ala Ala Ser Gly Ser Ile Ala Ser Ile His Ala Met Gly Trp Phe Arg 
            180                 185                 190         


Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ala Val Ile Thr Trp Ser 
        195                 200                 205             


Gly Gly Ile Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
    210                 215                 220                 


Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu 
225                 230                 235                 240 


Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Ala Gly Asp Lys His Gln 
                245                 250                 255     


Ser Ser Trp Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            260                 265                 270         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        275                 280                 285             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    290                 295                 300                 


Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val 
305                 310                 315                 320 


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr 
                325                 330                 335     


Phe Ser Phe Tyr Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu 
            340                 345                 350         


Gln Glu Phe Val Ala Asp Ile Arg Thr Ser Ala Gly Arg Thr Tyr Tyr 
        355                 360                 365             


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys 
    370                 375                 380                 


Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala 
385                 390                 395                 400 


Leu Tyr Tyr Cys Ala Ala Glu Met Ser Gly Ile Ser Gly Trp Asp Tyr 
                405                 410                 415     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
            420                 425                 430         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        435                 440                 445             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
    450                 455                 460                 


Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly Ser Leu 
465                 470                 475                 480 


Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr Phe Ser Phe Tyr Gly Met 
                485                 490                 495     


Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Gln Glu Phe Val Ala Asp 
            500                 505                 510         


Ile Arg Thr Ser Ala Gly Arg Thr Tyr Tyr Ala Asp Ser Val Lys Gly 
        515                 520                 525             


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu Gln 
    530                 535                 540                 


Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Ala Ala 
545                 550                 555                 560 


Glu Met Ser Gly Ile Ser Gly Trp Asp Tyr Trp Gly Gln Gly Thr Leu 
                565                 570                 575     


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
            580                 585                 590         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        595                 600                 605             


Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Leu Glu Ser Gly 
    610                 615                 620                 


Gly Gly Val Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 
625                 630                 635                 640 


Ser Gly Phe Thr Phe Arg Ser Phe Gly Met Ser Trp Val Arg Gln Ala 
                645                 650                 655     


Pro Gly Lys Gly Pro Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Ser 
            660                 665                 670         


Asp Thr Leu Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
        675                 680                 685             


Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro 
    690                 695                 700                 


Glu Asp Thr Ala Leu Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser Arg 
705                 710                 715                 720 


Ser Ser Gln Gly Thr Leu Val Thr Val Ser Ser Ala 
                725                 730         


<210>  106
<211>  732
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized lama

<400>  106

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Ala Ser Ile His 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Val Ile Thr Trp Ser Gly Gly Ile Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Gly Asp Lys His Gln Ser Ser Trp Tyr Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu 
145                 150                 155                 160 


Ser Gly Gly Gly Val Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
                165                 170                 175     


Ala Ala Ser Gly Ser Ile Ala Ser Ile His Ala Met Gly Trp Phe Arg 
            180                 185                 190         


Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ala Val Ile Thr Trp Ser 
        195                 200                 205             


Gly Gly Ile Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
    210                 215                 220                 


Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu 
225                 230                 235                 240 


Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Ala Gly Asp Lys His Gln 
                245                 250                 255     


Ser Ser Trp Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            260                 265                 270         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        275                 280                 285             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    290                 295                 300                 


Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val 
305                 310                 315                 320 


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr 
                325                 330                 335     


Phe Ser Phe Tyr Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu 
            340                 345                 350         


Arg Glu Phe Val Ala Asp Ile Arg Thr Ser Ala Gly Arg Thr Tyr Tyr 
        355                 360                 365             


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys 
    370                 375                 380                 


Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala 
385                 390                 395                 400 


Leu Tyr Tyr Cys Ala Ala Glu Met Ser Gly Ile Ser Gly Trp Asp Tyr 
                405                 410                 415     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
            420                 425                 430         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        435                 440                 445             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
    450                 455                 460                 


Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly Ser Leu 
465                 470                 475                 480 


Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr Phe Ser Phe Tyr Gly Met 
                485                 490                 495     


Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ala Asp 
            500                 505                 510         


Ile Arg Thr Ser Ala Gly Arg Thr Tyr Tyr Ala Asp Ser Val Lys Gly 
        515                 520                 525             


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu Gln 
    530                 535                 540                 


Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Ala Ala 
545                 550                 555                 560 


Glu Met Ser Gly Ile Ser Gly Trp Asp Tyr Trp Gly Gln Gly Thr Leu 
                565                 570                 575     


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
            580                 585                 590         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        595                 600                 605             


Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Leu Glu Ser Gly 
    610                 615                 620                 


Gly Gly Val Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 
625                 630                 635                 640 


Ser Gly Phe Thr Phe Arg Ser Phe Gly Met Ser Trp Val Arg Gln Ala 
                645                 650                 655     


Pro Gly Lys Gly Pro Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Ser 
            660                 665                 670         


Asp Thr Leu Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
        675                 680                 685             


Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro 
    690                 695                 700                 


Glu Asp Thr Ala Leu Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser Arg 
705                 710                 715                 720 


Ser Ser Gln Gly Thr Leu Val Thr Val Ser Ser Ala 
                725                 730         


<210>  107
<211>  732
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized lama

<400>  107

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr Phe Ser Phe Tyr 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Gln Glu Phe Val 
        35                  40                  45              


Ala Asp Ile Arg Thr Ser Ala Gly Arg Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Glu Met Ser Gly Ile Ser Gly Trp Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu 
145                 150                 155                 160 


Ser Gly Gly Gly Val Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
                165                 170                 175     


Ala Ala Ser Gly Gly Thr Phe Ser Phe Tyr Gly Met Gly Trp Phe Arg 
            180                 185                 190         


Gln Ala Pro Gly Lys Glu Gln Glu Phe Val Ala Asp Ile Arg Thr Ser 
        195                 200                 205             


Ala Gly Arg Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
    210                 215                 220                 


Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu 
225                 230                 235                 240 


Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Ala Ala Glu Met Ser Gly 
                245                 250                 255     


Ile Ser Gly Trp Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            260                 265                 270         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        275                 280                 285             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    290                 295                 300                 


Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val 
305                 310                 315                 320 


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile 
                325                 330                 335     


Ala Ser Ile His Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu 
            340                 345                 350         


Arg Glu Phe Val Ala Val Ile Thr Trp Ser Gly Gly Ile Thr Tyr Tyr 
        355                 360                 365             


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys 
    370                 375                 380                 


Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala 
385                 390                 395                 400 


Leu Tyr Tyr Cys Ala Gly Asp Lys His Gln Ser Ser Trp Tyr Asp Tyr 
                405                 410                 415     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
            420                 425                 430         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        435                 440                 445             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
    450                 455                 460                 


Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly Ser Leu 
465                 470                 475                 480 


Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Ala Ser Ile His Ala Met 
                485                 490                 495     


Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ala Val 
            500                 505                 510         


Ile Thr Trp Ser Gly Gly Ile Thr Tyr Tyr Ala Asp Ser Val Lys Gly 
        515                 520                 525             


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu Gln 
    530                 535                 540                 


Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Ala Gly 
545                 550                 555                 560 


Asp Lys His Gln Ser Ser Trp Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
                565                 570                 575     


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
            580                 585                 590         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        595                 600                 605             


Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly 
    610                 615                 620                 


Gly Gly Leu Val Gln Pro Gly Asn Ser Leu Arg Leu Ser Cys Ala Ala 
625                 630                 635                 640 


Ser Gly Phe Thr Phe Ser Ser Phe Gly Met Ser Trp Val Arg Gln Ala 
                645                 650                 655     


Pro Gly Lys Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Ser 
            660                 665                 670         


Asp Thr Leu Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
        675                 680                 685             


Asp Asn Ala Lys Thr Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro 
    690                 695                 700                 


Glu Asp Thr Ala Val Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser Arg 
705                 710                 715                 720 


Ser Ser Gln Gly Thr Leu Val Thr Val Ser Ser Ala 
                725                 730         


<210>  108
<211>  732
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized lama

<400>  108

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr Phe Ser Phe Tyr 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Asp Ile Arg Thr Ser Ala Gly Arg Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Glu Met Ser Gly Ile Ser Gly Trp Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu 
145                 150                 155                 160 


Ser Gly Gly Gly Val Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
                165                 170                 175     


Ala Ala Ser Gly Gly Thr Phe Ser Phe Tyr Gly Met Gly Trp Phe Arg 
            180                 185                 190         


Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ala Asp Ile Arg Thr Ser 
        195                 200                 205             


Ala Gly Arg Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
    210                 215                 220                 


Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu 
225                 230                 235                 240 


Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Ala Ala Glu Met Ser Gly 
                245                 250                 255     


Ile Ser Gly Trp Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            260                 265                 270         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        275                 280                 285             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    290                 295                 300                 


Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val 
305                 310                 315                 320 


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile 
                325                 330                 335     


Ala Ser Ile His Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu 
            340                 345                 350         


Arg Glu Phe Val Ala Val Ile Thr Trp Ser Gly Gly Ile Thr Tyr Tyr 
        355                 360                 365             


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys 
    370                 375                 380                 


Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala 
385                 390                 395                 400 


Leu Tyr Tyr Cys Ala Gly Asp Lys His Gln Ser Ser Trp Tyr Asp Tyr 
                405                 410                 415     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
            420                 425                 430         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        435                 440                 445             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
    450                 455                 460                 


Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly Ser Leu 
465                 470                 475                 480 


Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Ala Ser Ile His Ala Met 
                485                 490                 495     


Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ala Val 
            500                 505                 510         


Ile Thr Trp Ser Gly Gly Ile Thr Tyr Tyr Ala Asp Ser Val Lys Gly 
        515                 520                 525             


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu Gln 
    530                 535                 540                 


Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Ala Gly 
545                 550                 555                 560 


Asp Lys His Gln Ser Ser Trp Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
                565                 570                 575     


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
            580                 585                 590         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        595                 600                 605             


Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly 
    610                 615                 620                 


Gly Gly Leu Val Gln Pro Gly Asn Ser Leu Arg Leu Ser Cys Ala Ala 
625                 630                 635                 640 


Ser Gly Phe Thr Phe Ser Ser Phe Gly Met Ser Trp Val Arg Gln Ala 
                645                 650                 655     


Pro Gly Lys Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Ser 
            660                 665                 670         


Asp Thr Leu Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
        675                 680                 685             


Asp Asn Ala Lys Thr Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro 
    690                 695                 700                 


Glu Asp Thr Ala Val Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser Arg 
705                 710                 715                 720 


Ser Ser Gln Gly Thr Leu Val Thr Val Ser Ser Ala 
                725                 730         


<210>  109
<211>  732
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized lama

<400>  109

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr Phe Ser Phe Tyr 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Gln Glu Phe Val 
        35                  40                  45              


Ala Asp Ile Arg Thr Ser Ala Gly Arg Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Glu Met Ser Gly Ile Ser Gly Trp Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu 
145                 150                 155                 160 


Ser Gly Gly Gly Val Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
                165                 170                 175     


Ala Ala Ser Gly Gly Thr Phe Ser Phe Tyr Gly Met Gly Trp Phe Arg 
            180                 185                 190         


Gln Ala Pro Gly Lys Glu Gln Glu Phe Val Ala Asp Ile Arg Thr Ser 
        195                 200                 205             


Ala Gly Arg Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
    210                 215                 220                 


Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu 
225                 230                 235                 240 


Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Ala Ala Glu Met Ser Gly 
                245                 250                 255     


Ile Ser Gly Trp Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            260                 265                 270         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        275                 280                 285             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    290                 295                 300                 


Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val 
305                 310                 315                 320 


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile 
                325                 330                 335     


Ala Ser Ile His Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu 
            340                 345                 350         


Arg Glu Phe Val Ala Val Ile Thr Trp Ser Gly Gly Ile Thr Tyr Tyr 
        355                 360                 365             


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys 
    370                 375                 380                 


Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala 
385                 390                 395                 400 


Leu Tyr Tyr Cys Ala Gly Asp Lys His Gln Ser Ser Trp Tyr Asp Tyr 
                405                 410                 415     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
            420                 425                 430         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        435                 440                 445             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
    450                 455                 460                 


Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly Ser Leu 
465                 470                 475                 480 


Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Ala Ser Ile His Ala Met 
                485                 490                 495     


Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ala Val 
            500                 505                 510         


Ile Thr Trp Ser Gly Gly Ile Thr Tyr Tyr Ala Asp Ser Val Lys Gly 
        515                 520                 525             


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu Gln 
    530                 535                 540                 


Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Ala Gly 
545                 550                 555                 560 


Asp Lys His Gln Ser Ser Trp Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
                565                 570                 575     


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
            580                 585                 590         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        595                 600                 605             


Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Leu Glu Ser Gly 
    610                 615                 620                 


Gly Gly Val Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 
625                 630                 635                 640 


Ser Gly Phe Thr Phe Arg Ser Phe Gly Met Ser Trp Val Arg Gln Ala 
                645                 650                 655     


Pro Gly Lys Gly Pro Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Ser 
            660                 665                 670         


Asp Thr Leu Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
        675                 680                 685             


Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro 
    690                 695                 700                 


Glu Asp Thr Ala Leu Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser Arg 
705                 710                 715                 720 


Ser Ser Gln Gly Thr Leu Val Thr Val Ser Ser Ala 
                725                 730         


<210>  110
<211>  732
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized lama

<400>  110

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr Phe Ser Phe Tyr 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Asp Ile Arg Thr Ser Ala Gly Arg Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Glu Met Ser Gly Ile Ser Gly Trp Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu 
145                 150                 155                 160 


Ser Gly Gly Gly Val Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
                165                 170                 175     


Ala Ala Ser Gly Gly Thr Phe Ser Phe Tyr Gly Met Gly Trp Phe Arg 
            180                 185                 190         


Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ala Asp Ile Arg Thr Ser 
        195                 200                 205             


Ala Gly Arg Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
    210                 215                 220                 


Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu 
225                 230                 235                 240 


Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Ala Ala Glu Met Ser Gly 
                245                 250                 255     


Ile Ser Gly Trp Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            260                 265                 270         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        275                 280                 285             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    290                 295                 300                 


Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val 
305                 310                 315                 320 


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile 
                325                 330                 335     


Ala Ser Ile His Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu 
            340                 345                 350         


Arg Glu Phe Val Ala Val Ile Thr Trp Ser Gly Gly Ile Thr Tyr Tyr 
        355                 360                 365             


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys 
    370                 375                 380                 


Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala 
385                 390                 395                 400 


Leu Tyr Tyr Cys Ala Gly Asp Lys His Gln Ser Ser Trp Tyr Asp Tyr 
                405                 410                 415     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
            420                 425                 430         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        435                 440                 445             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
    450                 455                 460                 


Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly Ser Leu 
465                 470                 475                 480 


Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Ala Ser Ile His Ala Met 
                485                 490                 495     


Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ala Val 
            500                 505                 510         


Ile Thr Trp Ser Gly Gly Ile Thr Tyr Tyr Ala Asp Ser Val Lys Gly 
        515                 520                 525             


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu Gln 
    530                 535                 540                 


Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Ala Gly 
545                 550                 555                 560 


Asp Lys His Gln Ser Ser Trp Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
                565                 570                 575     


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
            580                 585                 590         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        595                 600                 605             


Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Leu Glu Ser Gly 
    610                 615                 620                 


Gly Gly Val Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 
625                 630                 635                 640 


Ser Gly Phe Thr Phe Arg Ser Phe Gly Met Ser Trp Val Arg Gln Ala 
                645                 650                 655     


Pro Gly Lys Gly Pro Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Ser 
            660                 665                 670         


Asp Thr Leu Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
        675                 680                 685             


Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro 
    690                 695                 700                 


Glu Asp Thr Ala Leu Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser Arg 
705                 710                 715                 720 


Ser Ser Gln Gly Thr Leu Val Thr Val Ser Ser Ala 
                725                 730         


<210>  111
<211>  424
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized lama

<400>  111

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Ala Ser Ile His 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Val Ile Thr Trp Ser Gly Gly Ile Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Gly Asp Lys His Gln Ser Ser Trp Tyr Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu 
145                 150                 155                 160 


Ser Gly Gly Gly Val Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
                165                 170                 175     


Ala Ala Ser Gly Gly Thr Phe Ser Phe Tyr Gly Met Gly Trp Phe Arg 
            180                 185                 190         


Gln Ala Pro Gly Lys Glu Gln Glu Phe Val Ala Asp Ile Arg Thr Ser 
        195                 200                 205             


Ala Gly Arg Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
    210                 215                 220                 


Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu 
225                 230                 235                 240 


Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Ala Ala Glu Met Ser Gly 
                245                 250                 255     


Ile Ser Gly Trp Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            260                 265                 270         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        275                 280                 285             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    290                 295                 300                 


Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
305                 310                 315                 320 


Gln Pro Gly Asn Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr 
                325                 330                 335     


Phe Ser Ser Phe Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly 
            340                 345                 350         


Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr 
        355                 360                 365             


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys 
    370                 375                 380                 


Thr Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala 
385                 390                 395                 400 


Val Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly 
                405                 410                 415     


Thr Leu Val Thr Val Ser Ser Ala 
            420                 


<210>  112
<211>  424
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized lama

<400>  112

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Ala Ser Ile His 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Val Ile Thr Trp Ser Gly Gly Ile Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Gly Asp Lys His Gln Ser Ser Trp Tyr Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu 
145                 150                 155                 160 


Ser Gly Gly Gly Val Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
                165                 170                 175     


Ala Ala Ser Gly Gly Thr Phe Ser Phe Tyr Gly Met Gly Trp Phe Arg 
            180                 185                 190         


Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ala Asp Ile Arg Thr Ser 
        195                 200                 205             


Ala Gly Arg Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
    210                 215                 220                 


Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu 
225                 230                 235                 240 


Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Ala Ala Glu Met Ser Gly 
                245                 250                 255     


Ile Ser Gly Trp Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            260                 265                 270         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        275                 280                 285             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    290                 295                 300                 


Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
305                 310                 315                 320 


Gln Pro Gly Asn Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr 
                325                 330                 335     


Phe Ser Ser Phe Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly 
            340                 345                 350         


Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr 
        355                 360                 365             


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys 
    370                 375                 380                 


Thr Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala 
385                 390                 395                 400 


Val Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly 
                405                 410                 415     


Thr Leu Val Thr Val Ser Ser Ala 
            420                 


<210>  113
<211>  424
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized lama

<400>  113

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Ala Ser Ile His 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Val Ile Thr Trp Ser Gly Gly Ile Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Gly Asp Lys His Gln Ser Ser Trp Tyr Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu 
145                 150                 155                 160 


Ser Gly Gly Gly Val Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
                165                 170                 175     


Ala Ala Ser Gly Gly Thr Phe Ser Phe Tyr Gly Met Gly Trp Phe Arg 
            180                 185                 190         


Gln Ala Pro Gly Lys Glu Gln Glu Phe Val Ala Asp Ile Arg Thr Ser 
        195                 200                 205             


Ala Gly Arg Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
    210                 215                 220                 


Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu 
225                 230                 235                 240 


Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Ala Ala Glu Met Ser Gly 
                245                 250                 255     


Ile Ser Gly Trp Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            260                 265                 270         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        275                 280                 285             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    290                 295                 300                 


Gly Gly Gly Ser Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Val Val 
305                 310                 315                 320 


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr 
                325                 330                 335     


Phe Arg Ser Phe Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly 
            340                 345                 350         


Pro Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr 
        355                 360                 365             


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys 
    370                 375                 380                 


Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala 
385                 390                 395                 400 


Leu Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly 
                405                 410                 415     


Thr Leu Val Thr Val Ser Ser Ala 
            420                 


<210>  114
<211>  424
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized lama

<400>  114

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Ala Ser Ile His 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Val Ile Thr Trp Ser Gly Gly Ile Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Gly Asp Lys His Gln Ser Ser Trp Tyr Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu 
145                 150                 155                 160 


Ser Gly Gly Gly Val Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
                165                 170                 175     


Ala Ala Ser Gly Gly Thr Phe Ser Phe Tyr Gly Met Gly Trp Phe Arg 
            180                 185                 190         


Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ala Asp Ile Arg Thr Ser 
        195                 200                 205             


Ala Gly Arg Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
    210                 215                 220                 


Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu 
225                 230                 235                 240 


Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Ala Ala Glu Met Ser Gly 
                245                 250                 255     


Ile Ser Gly Trp Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            260                 265                 270         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        275                 280                 285             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    290                 295                 300                 


Gly Gly Gly Ser Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Val Val 
305                 310                 315                 320 


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr 
                325                 330                 335     


Phe Arg Ser Phe Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly 
            340                 345                 350         


Pro Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr 
        355                 360                 365             


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys 
    370                 375                 380                 


Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala 
385                 390                 395                 400 


Leu Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly 
                405                 410                 415     


Thr Leu Val Thr Val Ser Ser Ala 
            420                 


<210>  115
<211>  424
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized lama

<400>  115

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr Phe Ser Phe Tyr 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Gln Glu Phe Val 
        35                  40                  45              


Ala Asp Ile Arg Thr Ser Ala Gly Arg Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Glu Met Ser Gly Ile Ser Gly Trp Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu 
145                 150                 155                 160 


Ser Gly Gly Gly Val Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
                165                 170                 175     


Ala Ala Ser Gly Ser Ile Ala Ser Ile His Ala Met Gly Trp Phe Arg 
            180                 185                 190         


Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ala Val Ile Thr Trp Ser 
        195                 200                 205             


Gly Gly Ile Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
    210                 215                 220                 


Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu 
225                 230                 235                 240 


Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Ala Gly Asp Lys His Gln 
                245                 250                 255     


Ser Ser Trp Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            260                 265                 270         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        275                 280                 285             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    290                 295                 300                 


Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
305                 310                 315                 320 


Gln Pro Gly Asn Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr 
                325                 330                 335     


Phe Ser Ser Phe Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly 
            340                 345                 350         


Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr 
        355                 360                 365             


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys 
    370                 375                 380                 


Thr Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala 
385                 390                 395                 400 


Val Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly 
                405                 410                 415     


Thr Leu Val Thr Val Ser Ser Ala 
            420                 


<210>  116
<211>  424
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized lama

<400>  116

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr Phe Ser Phe Tyr 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Asp Ile Arg Thr Ser Ala Gly Arg Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Glu Met Ser Gly Ile Ser Gly Trp Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu 
145                 150                 155                 160 


Ser Gly Gly Gly Val Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
                165                 170                 175     


Ala Ala Ser Gly Ser Ile Ala Ser Ile His Ala Met Gly Trp Phe Arg 
            180                 185                 190         


Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ala Val Ile Thr Trp Ser 
        195                 200                 205             


Gly Gly Ile Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
    210                 215                 220                 


Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu 
225                 230                 235                 240 


Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Ala Gly Asp Lys His Gln 
                245                 250                 255     


Ser Ser Trp Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            260                 265                 270         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        275                 280                 285             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    290                 295                 300                 


Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
305                 310                 315                 320 


Gln Pro Gly Asn Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr 
                325                 330                 335     


Phe Ser Ser Phe Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly 
            340                 345                 350         


Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr 
        355                 360                 365             


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys 
    370                 375                 380                 


Thr Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala 
385                 390                 395                 400 


Val Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly 
                405                 410                 415     


Thr Leu Val Thr Val Ser Ser Ala 
            420                 


<210>  117
<211>  424
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized lama

<400>  117

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr Phe Ser Phe Tyr 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Gln Glu Phe Val 
        35                  40                  45              


Ala Asp Ile Arg Thr Ser Ala Gly Arg Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Glu Met Ser Gly Ile Ser Gly Trp Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu 
145                 150                 155                 160 


Ser Gly Gly Gly Val Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
                165                 170                 175     


Ala Ala Ser Gly Ser Ile Ala Ser Ile His Ala Met Gly Trp Phe Arg 
            180                 185                 190         


Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ala Val Ile Thr Trp Ser 
        195                 200                 205             


Gly Gly Ile Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
    210                 215                 220                 


Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu 
225                 230                 235                 240 


Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Ala Gly Asp Lys His Gln 
                245                 250                 255     


Ser Ser Trp Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            260                 265                 270         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        275                 280                 285             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    290                 295                 300                 


Gly Gly Gly Ser Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Val Val 
305                 310                 315                 320 


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr 
                325                 330                 335     


Phe Arg Ser Phe Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly 
            340                 345                 350         


Pro Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr 
        355                 360                 365             


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys 
    370                 375                 380                 


Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala 
385                 390                 395                 400 


Leu Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly 
                405                 410                 415     


Thr Leu Val Thr Val Ser Ser Ala 
            420                 


<210>  118
<211>  424
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized lama

<400>  118

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr Phe Ser Phe Tyr 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Asp Ile Arg Thr Ser Ala Gly Arg Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Glu Met Ser Gly Ile Ser Gly Trp Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu 
145                 150                 155                 160 


Ser Gly Gly Gly Val Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
                165                 170                 175     


Ala Ala Ser Gly Ser Ile Ala Ser Ile His Ala Met Gly Trp Phe Arg 
            180                 185                 190         


Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ala Val Ile Thr Trp Ser 
        195                 200                 205             


Gly Gly Ile Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
    210                 215                 220                 


Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu 
225                 230                 235                 240 


Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Ala Gly Asp Lys His Gln 
                245                 250                 255     


Ser Ser Trp Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            260                 265                 270         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        275                 280                 285             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    290                 295                 300                 


Gly Gly Gly Ser Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Val Val 
305                 310                 315                 320 


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr 
                325                 330                 335     


Phe Arg Ser Phe Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly 
            340                 345                 350         


Pro Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr 
        355                 360                 365             


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys 
    370                 375                 380                 


Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala 
385                 390                 395                 400 


Leu Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly 
                405                 410                 415     


Thr Leu Val Thr Val Ser Ser Ala 
            420                 


<210>  119
<211>  578
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized lama

<400>  119

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Ala Ser Ile His 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Val Ile Thr Trp Ser Gly Gly Ile Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Gly Asp Lys His Gln Ser Ser Trp Tyr Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu 
145                 150                 155                 160 


Ser Gly Gly Gly Val Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
                165                 170                 175     


Ala Ala Ser Gly Gly Thr Phe Ser Phe Tyr Gly Met Gly Trp Phe Arg 
            180                 185                 190         


Gln Ala Pro Gly Lys Glu Gln Glu Phe Val Ala Asp Ile Arg Thr Ser 
        195                 200                 205             


Ala Gly Arg Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
    210                 215                 220                 


Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu 
225                 230                 235                 240 


Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Ala Ala Glu Met Ser Gly 
                245                 250                 255     


Ile Ser Gly Trp Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            260                 265                 270         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        275                 280                 285             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    290                 295                 300                 


Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val 
305                 310                 315                 320 


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr 
                325                 330                 335     


Phe Ser Phe Tyr Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu 
            340                 345                 350         


Gln Glu Phe Val Ala Asp Ile Arg Thr Ser Ala Gly Arg Thr Tyr Tyr 
        355                 360                 365             


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys 
    370                 375                 380                 


Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala 
385                 390                 395                 400 


Leu Tyr Tyr Cys Ala Ala Glu Met Ser Gly Ile Ser Gly Trp Asp Tyr 
                405                 410                 415     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
            420                 425                 430         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        435                 440                 445             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
    450                 455                 460                 


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Asn Ser Leu 
465                 470                 475                 480 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe Gly Met 
                485                 490                 495     


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser 
            500                 505                 510         


Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val Lys Gly 
        515                 520                 525             


Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr Leu Gln 
    530                 535                 540                 


Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Thr Ile 
545                 550                 555                 560 


Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr Val Ser 
                565                 570                 575     


Ser Ala 
        


<210>  120
<211>  578
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized lama

<400>  120

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Ala Ser Ile His 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Val Ile Thr Trp Ser Gly Gly Ile Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Gly Asp Lys His Gln Ser Ser Trp Tyr Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu 
145                 150                 155                 160 


Ser Gly Gly Gly Val Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
                165                 170                 175     


Ala Ala Ser Gly Gly Thr Phe Ser Phe Tyr Gly Met Gly Trp Phe Arg 
            180                 185                 190         


Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ala Asp Ile Arg Thr Ser 
        195                 200                 205             


Ala Gly Arg Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
    210                 215                 220                 


Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu 
225                 230                 235                 240 


Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Ala Ala Glu Met Ser Gly 
                245                 250                 255     


Ile Ser Gly Trp Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            260                 265                 270         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        275                 280                 285             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    290                 295                 300                 


Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val 
305                 310                 315                 320 


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr 
                325                 330                 335     


Phe Ser Phe Tyr Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu 
            340                 345                 350         


Arg Glu Phe Val Ala Asp Ile Arg Thr Ser Ala Gly Arg Thr Tyr Tyr 
        355                 360                 365             


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys 
    370                 375                 380                 


Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala 
385                 390                 395                 400 


Leu Tyr Tyr Cys Ala Ala Glu Met Ser Gly Ile Ser Gly Trp Asp Tyr 
                405                 410                 415     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
            420                 425                 430         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        435                 440                 445             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
    450                 455                 460                 


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Asn Ser Leu 
465                 470                 475                 480 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe Gly Met 
                485                 490                 495     


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser 
            500                 505                 510         


Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val Lys Gly 
        515                 520                 525             


Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr Leu Gln 
    530                 535                 540                 


Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Thr Ile 
545                 550                 555                 560 


Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr Val Ser 
                565                 570                 575     


Ser Ala 
        


<210>  121
<211>  578
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized lama

<400>  121

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Ala Ser Ile His 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Val Ile Thr Trp Ser Gly Gly Ile Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Gly Asp Lys His Gln Ser Ser Trp Tyr Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu 
145                 150                 155                 160 


Ser Gly Gly Gly Val Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
                165                 170                 175     


Ala Ala Ser Gly Gly Thr Phe Ser Phe Tyr Gly Met Gly Trp Phe Arg 
            180                 185                 190         


Gln Ala Pro Gly Lys Glu Gln Glu Phe Val Ala Asp Ile Arg Thr Ser 
        195                 200                 205             


Ala Gly Arg Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
    210                 215                 220                 


Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu 
225                 230                 235                 240 


Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Ala Ala Glu Met Ser Gly 
                245                 250                 255     


Ile Ser Gly Trp Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            260                 265                 270         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        275                 280                 285             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    290                 295                 300                 


Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val 
305                 310                 315                 320 


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr 
                325                 330                 335     


Phe Ser Phe Tyr Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu 
            340                 345                 350         


Gln Glu Phe Val Ala Asp Ile Arg Thr Ser Ala Gly Arg Thr Tyr Tyr 
        355                 360                 365             


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys 
    370                 375                 380                 


Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala 
385                 390                 395                 400 


Leu Tyr Tyr Cys Ala Ala Glu Met Ser Gly Ile Ser Gly Trp Asp Tyr 
                405                 410                 415     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
            420                 425                 430         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        435                 440                 445             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
    450                 455                 460                 


Gln Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly Ser Leu 
465                 470                 475                 480 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Ser Phe Gly Met 
                485                 490                 495     


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Val Ser Ser 
            500                 505                 510         


Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val Lys Gly 
        515                 520                 525             


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
    530                 535                 540                 


Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Thr Ile 
545                 550                 555                 560 


Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr Val Ser 
                565                 570                 575     


Ser Ala 
        


<210>  122
<211>  578
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized lama

<400>  122

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Ala Ser Ile His 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Val Ile Thr Trp Ser Gly Gly Ile Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Gly Asp Lys His Gln Ser Ser Trp Tyr Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu 
145                 150                 155                 160 


Ser Gly Gly Gly Val Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
                165                 170                 175     


Ala Ala Ser Gly Gly Thr Phe Ser Phe Tyr Gly Met Gly Trp Phe Arg 
            180                 185                 190         


Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ala Asp Ile Arg Thr Ser 
        195                 200                 205             


Ala Gly Arg Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
    210                 215                 220                 


Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu 
225                 230                 235                 240 


Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Ala Ala Glu Met Ser Gly 
                245                 250                 255     


Ile Ser Gly Trp Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            260                 265                 270         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        275                 280                 285             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    290                 295                 300                 


Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val 
305                 310                 315                 320 


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr 
                325                 330                 335     


Phe Ser Phe Tyr Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu 
            340                 345                 350         


Arg Glu Phe Val Ala Asp Ile Arg Thr Ser Ala Gly Arg Thr Tyr Tyr 
        355                 360                 365             


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys 
    370                 375                 380                 


Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala 
385                 390                 395                 400 


Leu Tyr Tyr Cys Ala Ala Glu Met Ser Gly Ile Ser Gly Trp Asp Tyr 
                405                 410                 415     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
            420                 425                 430         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        435                 440                 445             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
    450                 455                 460                 


Gln Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly Ser Leu 
465                 470                 475                 480 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Ser Phe Gly Met 
                485                 490                 495     


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Val Ser Ser 
            500                 505                 510         


Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val Lys Gly 
        515                 520                 525             


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
    530                 535                 540                 


Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Thr Ile 
545                 550                 555                 560 


Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr Val Ser 
                565                 570                 575     


Ser Ala 
        


<210>  123
<211>  578
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized lama

<400>  123

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr Phe Ser Phe Tyr 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Gln Glu Phe Val 
        35                  40                  45              


Ala Asp Ile Arg Thr Ser Ala Gly Arg Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Glu Met Ser Gly Ile Ser Gly Trp Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu 
145                 150                 155                 160 


Ser Gly Gly Gly Val Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
                165                 170                 175     


Ala Ala Ser Gly Gly Thr Phe Ser Phe Tyr Gly Met Gly Trp Phe Arg 
            180                 185                 190         


Gln Ala Pro Gly Lys Glu Gln Glu Phe Val Ala Asp Ile Arg Thr Ser 
        195                 200                 205             


Ala Gly Arg Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
    210                 215                 220                 


Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu 
225                 230                 235                 240 


Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Ala Ala Glu Met Ser Gly 
                245                 250                 255     


Ile Ser Gly Trp Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            260                 265                 270         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        275                 280                 285             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    290                 295                 300                 


Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val 
305                 310                 315                 320 


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile 
                325                 330                 335     


Ala Ser Ile His Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu 
            340                 345                 350         


Arg Glu Phe Val Ala Val Ile Thr Trp Ser Gly Gly Ile Thr Tyr Tyr 
        355                 360                 365             


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys 
    370                 375                 380                 


Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala 
385                 390                 395                 400 


Leu Tyr Tyr Cys Ala Gly Asp Lys His Gln Ser Ser Trp Tyr Asp Tyr 
                405                 410                 415     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
            420                 425                 430         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        435                 440                 445             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
    450                 455                 460                 


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Asn Ser Leu 
465                 470                 475                 480 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe Gly Met 
                485                 490                 495     


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser 
            500                 505                 510         


Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val Lys Gly 
        515                 520                 525             


Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr Leu Gln 
    530                 535                 540                 


Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Thr Ile 
545                 550                 555                 560 


Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr Val Ser 
                565                 570                 575     


Ser Ala 
        


<210>  124
<211>  578
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized lama

<400>  124

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr Phe Ser Phe Tyr 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Asp Ile Arg Thr Ser Ala Gly Arg Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Glu Met Ser Gly Ile Ser Gly Trp Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu 
145                 150                 155                 160 


Ser Gly Gly Gly Val Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
                165                 170                 175     


Ala Ala Ser Gly Gly Thr Phe Ser Phe Tyr Gly Met Gly Trp Phe Arg 
            180                 185                 190         


Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ala Asp Ile Arg Thr Ser 
        195                 200                 205             


Ala Gly Arg Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
    210                 215                 220                 


Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu 
225                 230                 235                 240 


Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Ala Ala Glu Met Ser Gly 
                245                 250                 255     


Ile Ser Gly Trp Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            260                 265                 270         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        275                 280                 285             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    290                 295                 300                 


Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val 
305                 310                 315                 320 


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile 
                325                 330                 335     


Ala Ser Ile His Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu 
            340                 345                 350         


Arg Glu Phe Val Ala Val Ile Thr Trp Ser Gly Gly Ile Thr Tyr Tyr 
        355                 360                 365             


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys 
    370                 375                 380                 


Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala 
385                 390                 395                 400 


Leu Tyr Tyr Cys Ala Gly Asp Lys His Gln Ser Ser Trp Tyr Asp Tyr 
                405                 410                 415     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
            420                 425                 430         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        435                 440                 445             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
    450                 455                 460                 


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Asn Ser Leu 
465                 470                 475                 480 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe Gly Met 
                485                 490                 495     


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser 
            500                 505                 510         


Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val Lys Gly 
        515                 520                 525             


Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr Leu Gln 
    530                 535                 540                 


Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Thr Ile 
545                 550                 555                 560 


Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr Val Ser 
                565                 570                 575     


Ser Ala 
        


<210>  125
<211>  578
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized lama

<400>  125

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr Phe Ser Phe Tyr 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Gln Glu Phe Val 
        35                  40                  45              


Ala Asp Ile Arg Thr Ser Ala Gly Arg Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Glu Met Ser Gly Ile Ser Gly Trp Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu 
145                 150                 155                 160 


Ser Gly Gly Gly Val Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
                165                 170                 175     


Ala Ala Ser Gly Gly Thr Phe Ser Phe Tyr Gly Met Gly Trp Phe Arg 
            180                 185                 190         


Gln Ala Pro Gly Lys Glu Gln Glu Phe Val Ala Asp Ile Arg Thr Ser 
        195                 200                 205             


Ala Gly Arg Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
    210                 215                 220                 


Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu 
225                 230                 235                 240 


Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Ala Ala Glu Met Ser Gly 
                245                 250                 255     


Ile Ser Gly Trp Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            260                 265                 270         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        275                 280                 285             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    290                 295                 300                 


Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val 
305                 310                 315                 320 


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile 
                325                 330                 335     


Ala Ser Ile His Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu 
            340                 345                 350         


Arg Glu Phe Val Ala Val Ile Thr Trp Ser Gly Gly Ile Thr Tyr Tyr 
        355                 360                 365             


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys 
    370                 375                 380                 


Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala 
385                 390                 395                 400 


Leu Tyr Tyr Cys Ala Gly Asp Lys His Gln Ser Ser Trp Tyr Asp Tyr 
                405                 410                 415     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
            420                 425                 430         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        435                 440                 445             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
    450                 455                 460                 


Gln Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly Ser Leu 
465                 470                 475                 480 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Ser Phe Gly Met 
                485                 490                 495     


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Val Ser Ser 
            500                 505                 510         


Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val Lys Gly 
        515                 520                 525             


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
    530                 535                 540                 


Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Thr Ile 
545                 550                 555                 560 


Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr Val Ser 
                565                 570                 575     


Ser Ala 
        


<210>  126
<211>  578
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized lama

<400>  126

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr Phe Ser Phe Tyr 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Asp Ile Arg Thr Ser Ala Gly Arg Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Glu Met Ser Gly Ile Ser Gly Trp Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu 
145                 150                 155                 160 


Ser Gly Gly Gly Val Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
                165                 170                 175     


Ala Ala Ser Gly Gly Thr Phe Ser Phe Tyr Gly Met Gly Trp Phe Arg 
            180                 185                 190         


Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ala Asp Ile Arg Thr Ser 
        195                 200                 205             


Ala Gly Arg Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
    210                 215                 220                 


Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu 
225                 230                 235                 240 


Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Ala Ala Glu Met Ser Gly 
                245                 250                 255     


Ile Ser Gly Trp Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            260                 265                 270         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        275                 280                 285             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    290                 295                 300                 


Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val 
305                 310                 315                 320 


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile 
                325                 330                 335     


Ala Ser Ile His Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu 
            340                 345                 350         


Arg Glu Phe Val Ala Val Ile Thr Trp Ser Gly Gly Ile Thr Tyr Tyr 
        355                 360                 365             


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys 
    370                 375                 380                 


Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala 
385                 390                 395                 400 


Leu Tyr Tyr Cys Ala Gly Asp Lys His Gln Ser Ser Trp Tyr Asp Tyr 
                405                 410                 415     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
            420                 425                 430         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        435                 440                 445             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
    450                 455                 460                 


Gln Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly Ser Leu 
465                 470                 475                 480 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Ser Phe Gly Met 
                485                 490                 495     


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Val Ser Ser 
            500                 505                 510         


Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val Lys Gly 
        515                 520                 525             


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
    530                 535                 540                 


Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Thr Ile 
545                 550                 555                 560 


Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr Val Ser 
                565                 570                 575     


Ser Ala 
        


<210>  127
<211>  578
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized lama

<400>  127

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Ala Ser Ile His 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Val Ile Thr Trp Ser Gly Gly Ile Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Gly Asp Lys His Gln Ser Ser Trp Tyr Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu 
145                 150                 155                 160 


Ser Gly Gly Gly Val Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
                165                 170                 175     


Ala Ala Ser Gly Ser Ile Ala Ser Ile His Ala Met Gly Trp Phe Arg 
            180                 185                 190         


Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ala Val Ile Thr Trp Ser 
        195                 200                 205             


Gly Gly Ile Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
    210                 215                 220                 


Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu 
225                 230                 235                 240 


Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Ala Gly Asp Lys His Gln 
                245                 250                 255     


Ser Ser Trp Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            260                 265                 270         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        275                 280                 285             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    290                 295                 300                 


Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val 
305                 310                 315                 320 


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr 
                325                 330                 335     


Phe Ser Phe Tyr Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu 
            340                 345                 350         


Arg Glu Phe Val Ala Asp Ile Arg Thr Ser Ala Gly Arg Thr Tyr Tyr 
        355                 360                 365             


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys 
    370                 375                 380                 


Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala 
385                 390                 395                 400 


Leu Tyr Tyr Cys Ala Ala Glu Met Ser Gly Ile Ser Gly Trp Asp Tyr 
                405                 410                 415     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
            420                 425                 430         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        435                 440                 445             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
    450                 455                 460                 


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Asn Ser Leu 
465                 470                 475                 480 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe Gly Met 
                485                 490                 495     


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser 
            500                 505                 510         


Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val Lys Gly 
        515                 520                 525             


Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr Leu Gln 
    530                 535                 540                 


Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Thr Ile 
545                 550                 555                 560 


Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr Val Ser 
                565                 570                 575     


Ser Ala 
        


<210>  128
<211>  578
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized lama

<400>  128

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Ala Ser Ile His 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Val Ile Thr Trp Ser Gly Gly Ile Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Gly Asp Lys His Gln Ser Ser Trp Tyr Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu 
145                 150                 155                 160 


Ser Gly Gly Gly Val Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
                165                 170                 175     


Ala Ala Ser Gly Ser Ile Ala Ser Ile His Ala Met Gly Trp Phe Arg 
            180                 185                 190         


Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ala Val Ile Thr Trp Ser 
        195                 200                 205             


Gly Gly Ile Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
    210                 215                 220                 


Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu 
225                 230                 235                 240 


Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Ala Gly Asp Lys His Gln 
                245                 250                 255     


Ser Ser Trp Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            260                 265                 270         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        275                 280                 285             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    290                 295                 300                 


Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val 
305                 310                 315                 320 


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr 
                325                 330                 335     


Phe Ser Phe Tyr Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu 
            340                 345                 350         


Gln Glu Phe Val Ala Asp Ile Arg Thr Ser Ala Gly Arg Thr Tyr Tyr 
        355                 360                 365             


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys 
    370                 375                 380                 


Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala 
385                 390                 395                 400 


Leu Tyr Tyr Cys Ala Ala Glu Met Ser Gly Ile Ser Gly Trp Asp Tyr 
                405                 410                 415     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
            420                 425                 430         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        435                 440                 445             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
    450                 455                 460                 


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Asn Ser Leu 
465                 470                 475                 480 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe Gly Met 
                485                 490                 495     


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser 
            500                 505                 510         


Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val Lys Gly 
        515                 520                 525             


Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr Leu Gln 
    530                 535                 540                 


Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Thr Ile 
545                 550                 555                 560 


Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr Val Ser 
                565                 570                 575     


Ser Ala 
        


<210>  129
<211>  578
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized lama

<400>  129

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Ala Ser Ile His 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Val Ile Thr Trp Ser Gly Gly Ile Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Gly Asp Lys His Gln Ser Ser Trp Tyr Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu 
145                 150                 155                 160 


Ser Gly Gly Gly Val Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
                165                 170                 175     


Ala Ala Ser Gly Ser Ile Ala Ser Ile His Ala Met Gly Trp Phe Arg 
            180                 185                 190         


Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ala Val Ile Thr Trp Ser 
        195                 200                 205             


Gly Gly Ile Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
    210                 215                 220                 


Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu 
225                 230                 235                 240 


Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Ala Gly Asp Lys His Gln 
                245                 250                 255     


Ser Ser Trp Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            260                 265                 270         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        275                 280                 285             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    290                 295                 300                 


Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val 
305                 310                 315                 320 


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr 
                325                 330                 335     


Phe Ser Phe Tyr Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu 
            340                 345                 350         


Arg Glu Phe Val Ala Asp Ile Arg Thr Ser Ala Gly Arg Thr Tyr Tyr 
        355                 360                 365             


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys 
    370                 375                 380                 


Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala 
385                 390                 395                 400 


Leu Tyr Tyr Cys Ala Ala Glu Met Ser Gly Ile Ser Gly Trp Asp Tyr 
                405                 410                 415     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
            420                 425                 430         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        435                 440                 445             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
    450                 455                 460                 


Gln Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly Ser Leu 
465                 470                 475                 480 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Ser Phe Gly Met 
                485                 490                 495     


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Val Ser Ser 
            500                 505                 510         


Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val Lys Gly 
        515                 520                 525             


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
    530                 535                 540                 


Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Thr Ile 
545                 550                 555                 560 


Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr Val Ser 
                565                 570                 575     


Ser Ala 
        


<210>  130
<211>  578
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized lama

<400>  130

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Ala Ser Ile His 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Val Ile Thr Trp Ser Gly Gly Ile Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Gly Asp Lys His Gln Ser Ser Trp Tyr Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu 
145                 150                 155                 160 


Ser Gly Gly Gly Val Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
                165                 170                 175     


Ala Ala Ser Gly Ser Ile Ala Ser Ile His Ala Met Gly Trp Phe Arg 
            180                 185                 190         


Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ala Val Ile Thr Trp Ser 
        195                 200                 205             


Gly Gly Ile Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
    210                 215                 220                 


Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu 
225                 230                 235                 240 


Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Ala Gly Asp Lys His Gln 
                245                 250                 255     


Ser Ser Trp Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            260                 265                 270         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        275                 280                 285             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    290                 295                 300                 


Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val 
305                 310                 315                 320 


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr 
                325                 330                 335     


Phe Ser Phe Tyr Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu 
            340                 345                 350         


Gln Glu Phe Val Ala Asp Ile Arg Thr Ser Ala Gly Arg Thr Tyr Tyr 
        355                 360                 365             


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys 
    370                 375                 380                 


Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala 
385                 390                 395                 400 


Leu Tyr Tyr Cys Ala Ala Glu Met Ser Gly Ile Ser Gly Trp Asp Tyr 
                405                 410                 415     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
            420                 425                 430         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        435                 440                 445             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
    450                 455                 460                 


Gln Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly Ser Leu 
465                 470                 475                 480 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Ser Phe Gly Met 
                485                 490                 495     


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Val Ser Ser 
            500                 505                 510         


Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val Lys Gly 
        515                 520                 525             


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
    530                 535                 540                 


Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Thr Ile 
545                 550                 555                 560 


Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr Val Ser 
                565                 570                 575     


Ser Ala 
        


<210>  131
<211>  578
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized lama

<400>  131

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr Phe Ser Phe Tyr 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Gln Glu Phe Val 
        35                  40                  45              


Ala Asp Ile Arg Thr Ser Ala Gly Arg Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Glu Met Ser Gly Ile Ser Gly Trp Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu 
145                 150                 155                 160 


Ser Gly Gly Gly Val Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
                165                 170                 175     


Ala Ala Ser Gly Ser Ile Ala Ser Ile His Ala Met Gly Trp Phe Arg 
            180                 185                 190         


Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ala Val Ile Thr Trp Ser 
        195                 200                 205             


Gly Gly Ile Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
    210                 215                 220                 


Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu 
225                 230                 235                 240 


Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Ala Gly Asp Lys His Gln 
                245                 250                 255     


Ser Ser Trp Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            260                 265                 270         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        275                 280                 285             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    290                 295                 300                 


Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val 
305                 310                 315                 320 


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile 
                325                 330                 335     


Ala Ser Ile His Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu 
            340                 345                 350         


Arg Glu Phe Val Ala Val Ile Thr Trp Ser Gly Gly Ile Thr Tyr Tyr 
        355                 360                 365             


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys 
    370                 375                 380                 


Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala 
385                 390                 395                 400 


Leu Tyr Tyr Cys Ala Gly Asp Lys His Gln Ser Ser Trp Tyr Asp Tyr 
                405                 410                 415     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
            420                 425                 430         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        435                 440                 445             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
    450                 455                 460                 


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Asn Ser Leu 
465                 470                 475                 480 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe Gly Met 
                485                 490                 495     


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser 
            500                 505                 510         


Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val Lys Gly 
        515                 520                 525             


Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr Leu Gln 
    530                 535                 540                 


Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Thr Ile 
545                 550                 555                 560 


Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr Val Ser 
                565                 570                 575     


Ser Ala 
        


<210>  132
<211>  578
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized lama

<400>  132

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr Phe Ser Phe Tyr 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Asp Ile Arg Thr Ser Ala Gly Arg Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Glu Met Ser Gly Ile Ser Gly Trp Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu 
145                 150                 155                 160 


Ser Gly Gly Gly Val Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
                165                 170                 175     


Ala Ala Ser Gly Ser Ile Ala Ser Ile His Ala Met Gly Trp Phe Arg 
            180                 185                 190         


Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ala Val Ile Thr Trp Ser 
        195                 200                 205             


Gly Gly Ile Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
    210                 215                 220                 


Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu 
225                 230                 235                 240 


Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Ala Gly Asp Lys His Gln 
                245                 250                 255     


Ser Ser Trp Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            260                 265                 270         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        275                 280                 285             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    290                 295                 300                 


Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val 
305                 310                 315                 320 


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile 
                325                 330                 335     


Ala Ser Ile His Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu 
            340                 345                 350         


Arg Glu Phe Val Ala Val Ile Thr Trp Ser Gly Gly Ile Thr Tyr Tyr 
        355                 360                 365             


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys 
    370                 375                 380                 


Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala 
385                 390                 395                 400 


Leu Tyr Tyr Cys Ala Gly Asp Lys His Gln Ser Ser Trp Tyr Asp Tyr 
                405                 410                 415     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
            420                 425                 430         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        435                 440                 445             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
    450                 455                 460                 


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Asn Ser Leu 
465                 470                 475                 480 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe Gly Met 
                485                 490                 495     


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser 
            500                 505                 510         


Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val Lys Gly 
        515                 520                 525             


Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr Leu Gln 
    530                 535                 540                 


Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Thr Ile 
545                 550                 555                 560 


Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr Val Ser 
                565                 570                 575     


Ser Ala 
        


<210>  133
<211>  578
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized lama

<400>  133

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr Phe Ser Phe Tyr 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Gln Glu Phe Val 
        35                  40                  45              


Ala Asp Ile Arg Thr Ser Ala Gly Arg Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Glu Met Ser Gly Ile Ser Gly Trp Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu 
145                 150                 155                 160 


Ser Gly Gly Gly Val Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
                165                 170                 175     


Ala Ala Ser Gly Ser Ile Ala Ser Ile His Ala Met Gly Trp Phe Arg 
            180                 185                 190         


Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ala Val Ile Thr Trp Ser 
        195                 200                 205             


Gly Gly Ile Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
    210                 215                 220                 


Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu 
225                 230                 235                 240 


Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Ala Gly Asp Lys His Gln 
                245                 250                 255     


Ser Ser Trp Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            260                 265                 270         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        275                 280                 285             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    290                 295                 300                 


Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val 
305                 310                 315                 320 


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile 
                325                 330                 335     


Ala Ser Ile His Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu 
            340                 345                 350         


Arg Glu Phe Val Ala Val Ile Thr Trp Ser Gly Gly Ile Thr Tyr Tyr 
        355                 360                 365             


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys 
    370                 375                 380                 


Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala 
385                 390                 395                 400 


Leu Tyr Tyr Cys Ala Gly Asp Lys His Gln Ser Ser Trp Tyr Asp Tyr 
                405                 410                 415     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
            420                 425                 430         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        435                 440                 445             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
    450                 455                 460                 


Gln Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly Ser Leu 
465                 470                 475                 480 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Ser Phe Gly Met 
                485                 490                 495     


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Val Ser Ser 
            500                 505                 510         


Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val Lys Gly 
        515                 520                 525             


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
    530                 535                 540                 


Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Thr Ile 
545                 550                 555                 560 


Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr Val Ser 
                565                 570                 575     


Ser Ala 
        


<210>  134
<211>  578
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized lama

<400>  134

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr Phe Ser Phe Tyr 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Asp Ile Arg Thr Ser Ala Gly Arg Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Glu Met Ser Gly Ile Ser Gly Trp Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu 
145                 150                 155                 160 


Ser Gly Gly Gly Val Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
                165                 170                 175     


Ala Ala Ser Gly Ser Ile Ala Ser Ile His Ala Met Gly Trp Phe Arg 
            180                 185                 190         


Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ala Val Ile Thr Trp Ser 
        195                 200                 205             


Gly Gly Ile Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
    210                 215                 220                 


Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu 
225                 230                 235                 240 


Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Ala Gly Asp Lys His Gln 
                245                 250                 255     


Ser Ser Trp Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            260                 265                 270         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        275                 280                 285             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    290                 295                 300                 


Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val 
305                 310                 315                 320 


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile 
                325                 330                 335     


Ala Ser Ile His Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu 
            340                 345                 350         


Arg Glu Phe Val Ala Val Ile Thr Trp Ser Gly Gly Ile Thr Tyr Tyr 
        355                 360                 365             


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys 
    370                 375                 380                 


Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala 
385                 390                 395                 400 


Leu Tyr Tyr Cys Ala Gly Asp Lys His Gln Ser Ser Trp Tyr Asp Tyr 
                405                 410                 415     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
            420                 425                 430         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        435                 440                 445             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
    450                 455                 460                 


Gln Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly Ser Leu 
465                 470                 475                 480 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Ser Phe Gly Met 
                485                 490                 495     


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Val Ser Ser 
            500                 505                 510         


Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val Lys Gly 
        515                 520                 525             


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
    530                 535                 540                 


Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Thr Ile 
545                 550                 555                 560 


Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr Val Ser 
                565                 570                 575     


Ser Ala 
        


<210>  135
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized lama

<400>  135

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Ala Ser Ile His 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Val Ile Thr Trp Ser Gly Gly Ile Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Gly Asp Lys His Gln Ser Ser Trp Tyr Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  136
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized lama

<400>  136

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Ala Ser Ile His 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Val Ile Thr Trp Ser Gly Gly Ile Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Gly Asp Lys His Gln Ser Ser Trp Tyr Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  137
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized lama

<400>  137

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Ala Ser Ile His 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Val Ile Thr Trp Ser Gly Gly Ile Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Gly Asp Lys His Gln Ser Ser Trp Tyr Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  138
<211>  270
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized lama

<400>  138

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Ala Ser Ile His 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Val Ile Thr Trp Ser Gly Gly Ile Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Gly Asp Lys His Gln Ser Ser Trp Tyr Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu 
145                 150                 155                 160 


Ser Gly Gly Gly Val Val Gln Pro Gly Asn Ser Leu Arg Leu Ser Cys 
                165                 170                 175     


Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe Gly Met Ser Trp Val Arg 
            180                 185                 190         


Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser 
        195                 200                 205             


Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
    210                 215                 220                 


Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr Leu Gln Met Asn Ser Leu 
225                 230                 235                 240 


Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Thr Ile Gly Gly Ser Leu 
                245                 250                 255     


Ser Arg Ser Ser Gln Gly Thr Leu Val Thr Val Ser Ser Ala 
            260                 265                 270 


<210>  139
<211>  424
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized lama

<400>  139

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Ala Ser Ile His 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Val Ile Thr Trp Ser Gly Gly Ile Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Gly Asp Lys His Gln Ser Ser Trp Tyr Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu 
145                 150                 155                 160 


Ser Gly Gly Gly Val Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
                165                 170                 175     


Ala Ala Ser Gly Ser Ile Ala Ser Ile His Ala Met Gly Trp Phe Arg 
            180                 185                 190         


Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ala Val Ile Thr Trp Ser 
        195                 200                 205             


Gly Gly Ile Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
    210                 215                 220                 


Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu 
225                 230                 235                 240 


Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Ala Gly Asp Lys His Gln 
                245                 250                 255     


Ser Ser Trp Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            260                 265                 270         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        275                 280                 285             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    290                 295                 300                 


Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val 
305                 310                 315                 320 


Gln Pro Gly Asn Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr 
                325                 330                 335     


Phe Ser Ser Phe Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly 
            340                 345                 350         


Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr 
        355                 360                 365             


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys 
    370                 375                 380                 


Thr Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala 
385                 390                 395                 400 


Leu Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly 
                405                 410                 415     


Thr Leu Val Thr Val Ser Ser Ala 
            420                 


<210>  140
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized lama

<400>  140

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Ala Ser Ile His 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Val Ile Thr Val Ser Gly Gly Ile Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Gly Asp Lys His Gln Ser Ser Phe Tyr Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  141
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized lama

<400>  141

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Ala Ser Ile His 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Val Ile Thr Val Ser Gly Gly Ile Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Gln Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Gly Asp Lys His Gln Ser Ser Phe Tyr Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  142
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized lama

<400>  142

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Ala Ser Ile His 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Val Ile Thr Val Ser Gly Gly Ile Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Pro Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Gly Asp Lys His Gln Ser Ser Phe Tyr Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  143
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized lama

<400>  143

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr Phe Ser Phe Tyr 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Asp Ile Arg Thr Ser Ala Gly Arg Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Glu Pro Ser Gly Ile Ser Gly Trp Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  144
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized lama


<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  X is L or V

<220>
<221>  MISC_FEATURE
<222>  (93)..(93)
<223>  X is L or V

<400>  144

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Xaa Val Gln Pro Gly Asn 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Xaa Tyr Tyr Cys 
                85                  90                  95      


Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu 
            100                 105                 110 


<210>  145
<211>  1272
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  humanized lama

<400>  145
gacgtgcaat tggtggagtc tggtggcgga gttgtccagc ctggcggcag tctgcggtta       60

tcttgcgccg cttctggcag cattgccagt attcacgcta tgggttggtt caggcaggct      120

cctggtaaag aacgtgagtt tgtggctgtg attacttggt ccggtggtat tacttactac      180

gctgatagcg ttaagggccg gtttacaatt tcccgtgata atagcaaaaa taccgtctat      240

ctgcaaatga acagtctgcg cccggaagat accgccctgt attactgtgc gggcgataaa      300

catcagtcct catggtatga ctactggggg caagggaccc tggtcacggt ctcctccgga      360

ggcggtgggt caggtggcgg aggcagcggt ggaggaggta gtggcggtgg cggtagtggg      420

ggtggaggca gcggaggcgg aggcagtggg ggcggtggat ccgaggtgca gttggtggag      480

tctgggggag gagtggtgca gccggggggc tctctgagac tctcctgtgc agcctctggt      540

ggcaccttca gtttctatgg catgggctgg ttccgccagg ctccagggaa ggagcgcgag      600

tttgtagcag atattagaac cagtgctggt aggacatact atgcagactc cgtgaagggc      660

cgattcacca tctccagaga caacagcaag aacacggtgt atctgcaaat gaacagcctg      720

cgccctgagg acacggccct gtattactgt gcagcagagc caagtggaat aagtggttgg      780

gactactggg gccaggggac cctggtcacg gtctcgagcg gaggcggtgg gtcaggtggc      840

ggaggcagcg gtggaggagg tagtggcggt ggcggtagtg ggggtggagg cagcggaggc      900

ggaggcagtg ggggcggtgg ctcagaggta caactagtgg agtctggagg tggcgttgtg      960

caaccgggta acagtctgcg ccttagctgc gcagcgtctg gctttacctt cagctccttt     1020

ggcatgagct gggttcgcca ggctccggga aaaggactgg aatgggtttc gtctattagc     1080

ggcagtggta gcgatacgct ctacgcggac tccgtgaagg gccgtttcac catctcccgc     1140

gataacgcca aaactacact gtatctgcaa atgaatagcc tgcgtcctga agatacggcc     1200

ctgtattact gtactattgg tggctcgtta agccgttctt cacagggtac cctggtcacc     1260

gtctcctcag cg                                                         1272


<210>  146
<211>  424
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized lama

<400>  146

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Ala Ser Ile His 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Val Ile Thr Trp Ser Gly Gly Ile Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Gly Asp Lys His Gln Ser Ser Trp Tyr Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu 
145                 150                 155                 160 


Ser Gly Gly Gly Val Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
                165                 170                 175     


Ala Ala Ser Gly Gly Thr Phe Ser Phe Tyr Gly Met Gly Trp Phe Arg 
            180                 185                 190         


Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ala Asp Ile Arg Thr Ser 
        195                 200                 205             


Ala Gly Arg Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
    210                 215                 220                 


Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu 
225                 230                 235                 240 


Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Ala Ala Glu Pro Ser Gly 
                245                 250                 255     


Ile Ser Gly Trp Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            260                 265                 270         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        275                 280                 285             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    290                 295                 300                 


Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val 
305                 310                 315                 320 


Gln Pro Gly Asn Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr 
                325                 330                 335     


Phe Ser Ser Phe Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly 
            340                 345                 350         


Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr 
        355                 360                 365             


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys 
    370                 375                 380                 


Thr Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala 
385                 390                 395                 400 


Leu Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly 
                405                 410                 415     


Thr Leu Val Thr Val Ser Ser Ala 
            420                 


<210>  147
<211>  85
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized lama

<400>  147

Met Arg Phe Pro Ser Ile Phe Thr Ala Val Leu Phe Ala Ala Ser Ser 
1               5                   10                  15      


Ala Leu Ala Ala Pro Val Asn Thr Thr Thr Glu Asp Glu Thr Ala Gln 
            20                  25                  30          


Ile Pro Ala Glu Ala Val Ile Gly Tyr Ser Asp Leu Glu Gly Asp Phe 
        35                  40                  45              


Asp Val Ala Val Leu Pro Phe Ser Asn Ser Thr Asn Asn Gly Leu Leu 
    50                  55                  60                  


Phe Ile Asn Thr Thr Ile Ala Ser Ile Ala Ala Lys Glu Glu Gly Val 
65                  70                  75                  80  


Ser Leu Glu Lys Arg 
                85  


<210>  148
<211>  1734
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  humanized lama

<400>  148
gacgtgcaat tggtggagtc tggtggcgga gttgtccagc ctggcggcag tctgcggtta       60

tcttgcgccg cttctggcag cattgccagt attcacgcta tgggttggtt caggcaggct      120

cctggtaaag aacgtgagtt tgtggctgtg attacttggt ccggtggtat tacttactac      180

gctgatagcg ttaagggccg gtttacaatt tcccgtgata atagcaaaaa taccgtctat      240

ctgcaaatga acagtctgcg cccggaagat accgccctgt attactgtgc gggcgataaa      300

catcagtcct catggtatga ctactggggg caagggaccc tggtcacggt ctcctccgga      360

ggcggtgggt caggtggcgg aggcagcggt ggaggaggta gtggcggtgg cggtagtggg      420

ggtggaggca gcggaggcgg aggcagtggg ggcggtggat cagaggtgca gttggtggag      480

tctggtggcg gagttgtcca gcctggcggc agtctgcggt tatcttgcgc cgcttctggc      540

agcattgcca gtattcacgc tatgggttgg ttcaggcagg ctcctggtaa agaacgtgag      600

tttgtggctg tgattacttg gtccggtggt attacttact acgctgatag cgttaagggc      660

cggtttacaa tttcccgtga taatagcaaa aataccgtct atctgcaaat gaacagtctg      720

cgcccggaag ataccgccct gtattactgt gcgggcgata aacatcagtc ctcatggtat      780

gactactggg ggcaagggac cctggtcacg gtctcctcag gaggcggtgg gtcaggtggc      840

ggaggcagcg gtggaggagg tagtggcggt ggcggtagtg ggggtggagg cagcggaggc      900

ggaggcagtg ggggcggtgg atccgaggtg cagttggtgg agtctggggg aggagtggtg      960

cagccggggg gctctctgag actctcctgt gcagcctctg gtggcacctt cagtttctat     1020

ggcatgggct ggttccgcca ggctccaggg aaggagcgcg agtttgtagc agatattaga     1080

accagtgctg gtaggacata ctatgcagac tccgtgaagg gccgattcac catctccaga     1140

gacaacagca agaacacggt gtatctgcaa atgaacagcc tgcgccctga ggacacggcc     1200

ctgtattact gtgcagcaga gccaagtgga ataagtggtt gggactactg gggccagggg     1260

accctggtca cggtctcgag cggaggcggt gggtcaggtg gcggaggcag cggtggagga     1320

ggtagtggcg gtggcggtag tgggggtgga ggcagcggag gcggaggcag tgggggcggt     1380

ggctcagagg tacaactagt ggagtctgga ggtggcgttg tgcaaccggg taacagtctg     1440

cgccttagct gcgcagcgtc tggctttacc ttcagctcct ttggcatgag ctgggttcgc     1500

caggctccgg gaaaaggact ggaatgggtt tcgtctatta gcggcagtgg tagcgatacg     1560

ctctacgcgg actccgtgaa gggccgtttc accatctccc gcgataacgc caaaactaca     1620

ctgtatctgc aaatgaatag cctgcgtcct gaagatacgg ccctgtatta ctgtactatt     1680

ggtggctcgt taagccgttc ttcacagggt accctggtca ccgtctcctc agcg           1734


<210>  149
<211>  578
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized lama

<400>  149

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Ala Ser Ile His 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Val Ile Thr Trp Ser Gly Gly Ile Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Gly Asp Lys His Gln Ser Ser Trp Tyr Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu 
145                 150                 155                 160 


Ser Gly Gly Gly Val Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
                165                 170                 175     


Ala Ala Ser Gly Ser Ile Ala Ser Ile His Ala Met Gly Trp Phe Arg 
            180                 185                 190         


Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ala Val Ile Thr Trp Ser 
        195                 200                 205             


Gly Gly Ile Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
    210                 215                 220                 


Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu 
225                 230                 235                 240 


Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Ala Gly Asp Lys His Gln 
                245                 250                 255     


Ser Ser Trp Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            260                 265                 270         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        275                 280                 285             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    290                 295                 300                 


Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val 
305                 310                 315                 320 


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr 
                325                 330                 335     


Phe Ser Phe Tyr Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu 
            340                 345                 350         


Arg Glu Phe Val Ala Asp Ile Arg Thr Ser Ala Gly Arg Thr Tyr Tyr 
        355                 360                 365             


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys 
    370                 375                 380                 


Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala 
385                 390                 395                 400 


Leu Tyr Tyr Cys Ala Ala Glu Pro Ser Gly Ile Ser Gly Trp Asp Tyr 
                405                 410                 415     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
            420                 425                 430         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        435                 440                 445             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
    450                 455                 460                 


Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Asn Ser Leu 
465                 470                 475                 480 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe Gly Met 
                485                 490                 495     


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser 
            500                 505                 510         


Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val Lys Gly 
        515                 520                 525             


Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr Leu Gln 
    530                 535                 540                 


Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Thr Ile 
545                 550                 555                 560 


Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr Val Ser 
                565                 570                 575     


Ser Ala 
        


<210>  150
<211>  1734
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized lama

<400>  150

Gly Ala Cys Gly Thr Gly Cys Ala Ala Thr Thr Gly Gly Thr Gly Gly 
1               5                   10                  15      


Ala Gly Thr Cys Thr Gly Gly Thr Gly Gly Cys Gly Gly Ala Gly Thr 
            20                  25                  30          


Thr Gly Thr Cys Cys Ala Gly Cys Cys Thr Gly Gly Cys Gly Gly Cys 
        35                  40                  45              


Ala Gly Thr Cys Thr Gly Cys Gly Gly Thr Thr Ala Thr Cys Thr Thr 
    50                  55                  60                  


Gly Cys Gly Cys Cys Gly Cys Thr Thr Cys Thr Gly Gly Cys Ala Gly 
65                  70                  75                  80  


Cys Ala Thr Thr Gly Cys Cys Ala Gly Thr Ala Thr Thr Cys Ala Cys 
                85                  90                  95      


Gly Cys Thr Ala Thr Gly Gly Gly Thr Thr Gly Gly Thr Thr Cys Ala 
            100                 105                 110         


Gly Gly Cys Ala Gly Gly Cys Thr Cys Cys Thr Gly Gly Thr Ala Ala 
        115                 120                 125             


Ala Gly Ala Ala Cys Gly Thr Gly Ala Gly Thr Thr Thr Gly Thr Gly 
    130                 135                 140                 


Gly Cys Thr Gly Thr Gly Ala Thr Thr Ala Cys Thr Thr Gly Gly Thr 
145                 150                 155                 160 


Cys Cys Gly Gly Thr Gly Gly Thr Ala Thr Thr Ala Cys Thr Thr Ala 
                165                 170                 175     


Cys Thr Ala Cys Gly Cys Thr Gly Ala Thr Ala Gly Cys Gly Thr Thr 
            180                 185                 190         


Ala Ala Gly Gly Gly Cys Cys Gly Gly Thr Thr Thr Ala Cys Ala Ala 
        195                 200                 205             


Thr Thr Thr Cys Cys Cys Gly Thr Gly Ala Thr Ala Ala Thr Ala Gly 
    210                 215                 220                 


Cys Ala Ala Ala Ala Ala Thr Ala Cys Cys Gly Thr Cys Thr Ala Thr 
225                 230                 235                 240 


Cys Thr Gly Cys Ala Ala Ala Thr Gly Ala Ala Cys Ala Gly Thr Cys 
                245                 250                 255     


Thr Gly Cys Gly Cys Cys Cys Gly Gly Ala Ala Gly Ala Thr Ala Cys 
            260                 265                 270         


Cys Gly Cys Cys Cys Thr Gly Thr Ala Thr Thr Ala Cys Thr Gly Thr 
        275                 280                 285             


Gly Cys Gly Gly Gly Cys Gly Ala Thr Ala Ala Ala Cys Ala Thr Cys 
    290                 295                 300                 


Ala Gly Thr Cys Cys Thr Cys Ala Thr Gly Gly Thr Ala Thr Gly Ala 
305                 310                 315                 320 


Cys Thr Ala Cys Thr Gly Gly Gly Gly Gly Cys Ala Ala Gly Gly Gly 
                325                 330                 335     


Ala Cys Cys Cys Thr Gly Gly Thr Cys Ala Cys Gly Gly Thr Cys Thr 
            340                 345                 350         


Cys Cys Thr Cys Cys Gly Gly Ala Gly Gly Cys Gly Gly Thr Gly Gly 
        355                 360                 365             


Gly Thr Cys Ala Gly Gly Thr Gly Gly Cys Gly Gly Ala Gly Gly Cys 
    370                 375                 380                 


Ala Gly Cys Gly Gly Thr Gly Gly Ala Gly Gly Ala Gly Gly Thr Ala 
385                 390                 395                 400 


Gly Thr Gly Gly Cys Gly Gly Thr Gly Gly Cys Gly Gly Thr Ala Gly 
                405                 410                 415     


Thr Gly Gly Gly Gly Gly Thr Gly Gly Ala Gly Gly Cys Ala Gly Cys 
            420                 425                 430         


Gly Gly Ala Gly Gly Cys Gly Gly Ala Gly Gly Cys Ala Gly Thr Gly 
        435                 440                 445             


Gly Gly Gly Gly Cys Gly Gly Thr Gly Gly Ala Thr Cys Cys Gly Ala 
    450                 455                 460                 


Gly Gly Thr Gly Cys Ala Gly Thr Thr Gly Gly Thr Gly Gly Ala Gly 
465                 470                 475                 480 


Thr Cys Thr Gly Gly Gly Gly Gly Ala Gly Gly Ala Gly Thr Gly Gly 
                485                 490                 495     


Thr Gly Cys Ala Gly Cys Cys Gly Gly Gly Gly Gly Gly Cys Thr Cys 
            500                 505                 510         


Thr Cys Thr Gly Ala Gly Ala Cys Thr Cys Thr Cys Cys Thr Gly Thr 
        515                 520                 525             


Gly Cys Ala Gly Cys Cys Thr Cys Thr Gly Gly Thr Gly Gly Cys Ala 
    530                 535                 540                 


Cys Cys Thr Thr Cys Ala Gly Thr Thr Thr Cys Thr Ala Thr Gly Gly 
545                 550                 555                 560 


Cys Ala Thr Gly Gly Gly Cys Thr Gly Gly Thr Thr Cys Cys Gly Cys 
                565                 570                 575     


Cys Ala Gly Gly Cys Thr Cys Cys Ala Gly Gly Gly Ala Ala Gly Gly 
            580                 585                 590         


Ala Gly Cys Gly Cys Gly Ala Gly Thr Thr Thr Gly Thr Ala Gly Cys 
        595                 600                 605             


Ala Gly Ala Thr Ala Thr Thr Ala Gly Ala Ala Cys Cys Ala Gly Thr 
    610                 615                 620                 


Gly Cys Thr Gly Gly Thr Ala Gly Gly Ala Cys Ala Thr Ala Cys Thr 
625                 630                 635                 640 


Ala Thr Gly Cys Ala Gly Ala Cys Thr Cys Cys Gly Thr Gly Ala Ala 
                645                 650                 655     


Gly Gly Gly Cys Cys Gly Ala Thr Thr Cys Ala Cys Cys Ala Thr Cys 
            660                 665                 670         


Thr Cys Cys Ala Gly Ala Gly Ala Cys Ala Ala Cys Ala Gly Cys Ala 
        675                 680                 685             


Ala Gly Ala Ala Cys Ala Cys Gly Gly Thr Gly Thr Ala Thr Cys Thr 
    690                 695                 700                 


Gly Cys Ala Ala Ala Thr Gly Ala Ala Cys Ala Gly Cys Cys Thr Gly 
705                 710                 715                 720 


Cys Gly Cys Cys Cys Thr Gly Ala Gly Gly Ala Cys Ala Cys Gly Gly 
                725                 730                 735     


Cys Cys Cys Thr Gly Thr Ala Thr Thr Ala Cys Thr Gly Thr Gly Cys 
            740                 745                 750         


Ala Gly Cys Ala Gly Ala Gly Cys Cys Ala Ala Gly Thr Gly Gly Ala 
        755                 760                 765             


Ala Thr Ala Ala Gly Thr Gly Gly Thr Thr Gly Gly Gly Ala Cys Thr 
    770                 775                 780                 


Ala Cys Thr Gly Gly Gly Gly Cys Cys Ala Gly Gly Gly Gly Ala Cys 
785                 790                 795                 800 


Cys Cys Thr Gly Gly Thr Cys Ala Cys Gly Gly Thr Cys Thr Cys Gly 
                805                 810                 815     


Ala Gly Cys Gly Gly Ala Gly Gly Cys Gly Gly Thr Gly Gly Gly Thr 
            820                 825                 830         


Cys Ala Gly Gly Thr Gly Gly Cys Gly Gly Ala Gly Gly Cys Ala Gly 
        835                 840                 845             


Cys Gly Gly Thr Gly Gly Ala Gly Gly Ala Gly Gly Thr Ala Gly Thr 
    850                 855                 860                 


Gly Gly Cys Gly Gly Thr Gly Gly Cys Gly Gly Thr Ala Gly Thr Gly 
865                 870                 875                 880 


Gly Gly Gly Gly Thr Gly Gly Ala Gly Gly Cys Ala Gly Cys Gly Gly 
                885                 890                 895     


Ala Gly Gly Cys Gly Gly Ala Gly Gly Cys Ala Gly Thr Gly Gly Gly 
            900                 905                 910         


Gly Gly Cys Gly Gly Thr Gly Gly Ala Thr Cys Ala Gly Ala Gly Gly 
        915                 920                 925             


Thr Gly Cys Ala Gly Thr Thr Gly Gly Thr Gly Gly Ala Gly Thr Cys 
    930                 935                 940                 


Thr Gly Gly Gly Gly Gly Ala Gly Gly Ala Gly Thr Gly Gly Thr Gly 
945                 950                 955                 960 


Cys Ala Gly Cys Cys Gly Gly Gly Gly Gly Gly Cys Thr Cys Thr Cys 
                965                 970                 975     


Thr Gly Ala Gly Ala Cys Thr Cys Thr Cys Cys Thr Gly Thr Gly Cys 
            980                 985                 990         


Ala Gly Cys Cys Thr Cys Thr Gly  Gly Thr Gly Gly Cys  Ala Cys Cys 
        995                 1000                 1005             


Thr Thr  Cys Ala Gly Thr Thr  Thr Cys Thr Ala Thr  Gly Gly Cys 
    1010                 1015                 1020             


Ala Thr  Gly Gly Gly Cys Thr  Gly Gly Thr Thr Cys  Cys Gly Cys 
    1025                 1030                 1035             


Cys Ala  Gly Gly Cys Thr Cys  Cys Ala Gly Gly Gly  Ala Ala Gly 
    1040                 1045                 1050             


Gly Ala  Gly Cys Gly Cys Gly  Ala Gly Thr Thr Thr  Gly Thr Ala 
    1055                 1060                 1065             


Gly Cys  Ala Gly Ala Thr Ala  Thr Thr Ala Gly Ala  Ala Cys Cys 
    1070                 1075                 1080             


Ala Gly  Thr Gly Cys Thr Gly  Gly Thr Ala Gly Gly  Ala Cys Ala 
    1085                 1090                 1095             


Thr Ala  Cys Thr Ala Thr Gly  Cys Ala Gly Ala Cys  Thr Cys Cys 
    1100                 1105                 1110             


Gly Thr  Gly Ala Ala Gly Gly  Gly Cys Cys Gly Ala  Thr Thr Cys 
    1115                 1120                 1125             


Ala Cys  Cys Ala Thr Cys Thr  Cys Cys Ala Gly Ala  Gly Ala Cys 
    1130                 1135                 1140             


Ala Ala  Cys Ala Gly Cys Ala  Ala Gly Ala Ala Cys  Ala Cys Gly 
    1145                 1150                 1155             


Gly Thr  Gly Thr Ala Thr Cys  Thr Gly Cys Ala Ala  Ala Thr Gly 
    1160                 1165                 1170             


Ala Ala  Cys Ala Gly Cys Cys  Thr Gly Cys Gly Cys  Cys Cys Thr 
    1175                 1180                 1185             


Gly Ala  Gly Gly Ala Cys Ala  Cys Gly Gly Cys Cys  Cys Thr Gly 
    1190                 1195                 1200             


Thr Ala  Thr Thr Ala Cys Thr  Gly Thr Gly Cys Ala  Gly Cys Ala 
    1205                 1210                 1215             


Gly Ala  Gly Cys Cys Ala Ala  Gly Thr Gly Gly Ala  Ala Thr Ala 
    1220                 1225                 1230             


Ala Gly  Thr Gly Gly Thr Thr  Gly Gly Gly Ala Cys  Thr Ala Cys 
    1235                 1240                 1245             


Thr Gly  Gly Gly Gly Cys Cys  Ala Gly Gly Gly Gly  Ala Cys Cys 
    1250                 1255                 1260             


Cys Thr  Gly Gly Thr Cys Ala  Cys Gly Gly Thr Cys  Thr Cys Cys 
    1265                 1270                 1275             


Thr Cys  Ala Gly Gly Ala Gly  Gly Cys Gly Gly Thr  Gly Gly Gly 
    1280                 1285                 1290             


Thr Cys  Ala Gly Gly Thr Gly  Gly Cys Gly Gly Ala  Gly Gly Cys 
    1295                 1300                 1305             


Ala Gly  Cys Gly Gly Thr Gly  Gly Ala Gly Gly Ala  Gly Gly Thr 
    1310                 1315                 1320             


Ala Gly  Thr Gly Gly Cys Gly  Gly Thr Gly Gly Cys  Gly Gly Thr 
    1325                 1330                 1335             


Ala Gly  Thr Gly Gly Gly Gly  Gly Thr Gly Gly Ala  Gly Gly Cys 
    1340                 1345                 1350             


Ala Gly  Cys Gly Gly Ala Gly  Gly Cys Gly Gly Ala  Gly Gly Cys 
    1355                 1360                 1365             


Ala Gly  Thr Gly Gly Gly Gly  Gly Cys Gly Gly Thr  Gly Gly Ala 
    1370                 1375                 1380             


Thr Cys  Ala Gly Ala Gly Gly  Thr Gly Cys Ala Ala  Cys Thr Ala 
    1385                 1390                 1395             


Gly Thr  Gly Gly Ala Gly Thr  Cys Thr Gly Gly Ala  Gly Gly Thr 
    1400                 1405                 1410             


Gly Gly  Cys Gly Thr Thr Gly  Thr Gly Cys Ala Ala  Cys Cys Gly 
    1415                 1420                 1425             


Gly Gly  Thr Ala Ala Cys Ala  Gly Thr Cys Thr Gly  Cys Gly Cys 
    1430                 1435                 1440             


Cys Thr  Thr Ala Gly Cys Thr  Gly Cys Gly Cys Ala  Gly Cys Gly 
    1445                 1450                 1455             


Thr Cys  Thr Gly Gly Cys Thr  Thr Thr Ala Cys Cys  Thr Thr Cys 
    1460                 1465                 1470             


Ala Gly  Cys Thr Cys Cys Thr  Thr Thr Gly Gly Cys  Ala Thr Gly 
    1475                 1480                 1485             


Ala Gly  Cys Thr Gly Gly Gly  Thr Thr Cys Gly Cys  Cys Ala Gly 
    1490                 1495                 1500             


Gly Cys  Thr Cys Cys Gly Gly  Gly Ala Ala Ala Ala  Gly Gly Ala 
    1505                 1510                 1515             


Cys Thr  Gly Gly Ala Ala Thr  Gly Gly Gly Thr Thr  Thr Cys Gly 
    1520                 1525                 1530             


Thr Cys  Thr Ala Thr Thr Ala  Gly Cys Gly Gly Cys  Ala Gly Thr 
    1535                 1540                 1545             


Gly Gly  Thr Ala Gly Cys Gly  Ala Thr Ala Cys Gly  Cys Thr Cys 
    1550                 1555                 1560             


Thr Ala  Cys Gly Cys Gly Gly  Ala Cys Thr Cys Cys  Gly Thr Gly 
    1565                 1570                 1575             


Ala Ala  Gly Gly Gly Cys Cys  Gly Thr Thr Thr Cys  Ala Cys Cys 
    1580                 1585                 1590             


Ala Thr  Cys Thr Cys Cys Cys  Gly Cys Gly Ala Thr  Ala Ala Cys 
    1595                 1600                 1605             


Gly Cys  Cys Ala Ala Ala Ala  Cys Thr Ala Cys Ala  Cys Thr Gly 
    1610                 1615                 1620             


Thr Ala  Thr Cys Thr Gly Cys  Ala Ala Ala Thr Gly  Ala Ala Thr 
    1625                 1630                 1635             


Ala Gly  Cys Cys Thr Gly Cys  Gly Thr Cys Cys Thr  Gly Ala Ala 
    1640                 1645                 1650             


Gly Ala  Thr Ala Cys Gly Gly  Cys Cys Cys Thr Gly  Thr Ala Thr 
    1655                 1660                 1665             


Thr Ala  Cys Thr Gly Thr Ala  Cys Thr Ala Thr Thr  Gly Gly Thr 
    1670                 1675                 1680             


Gly Gly  Cys Thr Cys Gly Thr  Thr Ala Ala Gly Cys  Cys Gly Thr 
    1685                 1690                 1695             


Thr Cys  Thr Thr Cys Ala Cys  Ala Gly Gly Gly Thr  Ala Cys Cys 
    1700                 1705                 1710             


Cys Thr  Gly Gly Thr Cys Ala  Cys Cys Gly Thr Cys  Thr Cys Cys 
    1715                 1720                 1725             


Thr Cys  Ala Gly Cys Gly 
    1730                 


<210>  151
<211>  578
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized lama

<400>  151

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Ala Ser Ile His 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Val Ile Thr Trp Ser Gly Gly Ile Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Gly Asp Lys His Gln Ser Ser Trp Tyr Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu 
145                 150                 155                 160 


Ser Gly Gly Gly Val Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
                165                 170                 175     


Ala Ala Ser Gly Gly Thr Phe Ser Phe Tyr Gly Met Gly Trp Phe Arg 
            180                 185                 190         


Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ala Asp Ile Arg Thr Ser 
        195                 200                 205             


Ala Gly Arg Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
    210                 215                 220                 


Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu 
225                 230                 235                 240 


Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Ala Ala Glu Pro Ser Gly 
                245                 250                 255     


Ile Ser Gly Trp Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            260                 265                 270         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        275                 280                 285             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    290                 295                 300                 


Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val 
305                 310                 315                 320 


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr 
                325                 330                 335     


Phe Ser Phe Tyr Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu 
            340                 345                 350         


Arg Glu Phe Val Ala Asp Ile Arg Thr Ser Ala Gly Arg Thr Tyr Tyr 
        355                 360                 365             


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys 
    370                 375                 380                 


Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala 
385                 390                 395                 400 


Leu Tyr Tyr Cys Ala Ala Glu Pro Ser Gly Ile Ser Gly Trp Asp Tyr 
                405                 410                 415     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
            420                 425                 430         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        435                 440                 445             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
    450                 455                 460                 


Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Asn Ser Leu 
465                 470                 475                 480 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe Gly Met 
                485                 490                 495     


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser 
            500                 505                 510         


Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val Lys Gly 
        515                 520                 525             


Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr Leu Gln 
    530                 535                 540                 


Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Thr Ile 
545                 550                 555                 560 


Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr Val Ser 
                565                 570                 575     


Ser Ala 
        


<210>  152
<211>  2196
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  humanized lama

<400>  152
gacgtgcaat tggtggagtc tggtggcgga gttgtccagc ctggcggcag tctgcggtta       60

tcttgcgccg cttctggcag cattgccagt attcacgcta tgggttggtt caggcaggct      120

cctggtaaag aacgtgagtt tgtggctgtg attacttggt ccggtggtat tacttactac      180

gctgatagcg ttaagggccg gtttacaatt tcccgtgata atagcaaaaa taccgtctat      240

ctgcaaatga acagtctgcg cccggaagat accgccctgt attactgtgc gggcgataaa      300

catcagtcct catggtatga ctactggggg caagggaccc tggtcacggt ctcctccgga      360

ggcggtgggt caggtggcgg aggcagcggt ggaggaggta gtggcggtgg cggtagtggg      420

ggtggaggca gcggaggcgg aggcagtggg ggcggtggat cagaggtgca gttggtggag      480

tctggtggcg gagttgtcca gcctggcggc agtctgcggt tatcttgcgc cgcttctggc      540

agcattgcca gtattcacgc tatgggttgg ttcaggcagg ctcctggtaa agaacgtgag      600

tttgtggctg tgattacttg gtccggtggt attacttact acgctgatag cgttaagggc      660

cggtttacaa tttcccgtga taatagcaaa aataccgtct atctgcaaat gaacagtctg      720

cgcccggaag ataccgccct gtattactgt gcgggcgata aacatcagtc ctcatggtat      780

gactactggg ggcaagggac cctggtcacg gtctcctcag gaggcggtgg gtcaggtggc      840

ggaggcagcg gtggaggagg tagtggcggt ggcggtagtg ggggtggagg cagcggaggc      900

ggaggcagtg ggggcggtgg atccgaggtg cagttggtgg agtctggggg aggagtggtg      960

cagccggggg gctctctgag actctcctgt gcagcctctg gtggcacctt cagtttctat     1020

ggcatgggct ggttccgcca ggctccaggg aaggagcgcg agtttgtagc agatattaga     1080

accagtgctg gtaggacata ctatgcagac tccgtgaagg gccgattcac catctccaga     1140

gacaacagca agaacacggt gtatctgcaa atgaacagcc tgcgccctga ggacacggcc     1200

ctgtattact gtgcagcaga gccaagtgga ataagtggtt gggactactg gggccagggg     1260

accctggtca cggtctcgag cggaggcggt gggtcaggtg gcggaggcag cggtggagga     1320

ggtagtggcg gtggcggtag tgggggtgga ggcagcggag gcggaggcag tgggggcggt     1380

ggatcagagg tgcagttggt ggagtctggg ggaggagtgg tgcagccggg gggctctctg     1440

agactctcct gtgcagcctc tggtggcacc ttcagtttct atggcatggg ctggttccgc     1500

caggctccag ggaaggagcg cgagtttgta gcagatatta gaaccagtgc tggtaggaca     1560

tactatgcag actccgtgaa gggccgattc accatctcca gagacaacag caagaacacg     1620

gtgtatctgc aaatgaacag cctgcgccct gaggacacgg ccctgtatta ctgtgcagca     1680

gagccaagtg gaataagtgg ttgggactac tggggccagg ggaccctggt cacggtctcc     1740

tcaggaggcg gtgggtcagg tggcggaggc agcggtggag gaggtagtgg cggtggcggt     1800

agtgggggtg gaggcagcgg aggcggaggc agtgggggcg gtggatcaga ggtgcaacta     1860

gtggagtctg gaggtggcgt tgtgcaaccg ggtaacagtc tgcgccttag ctgcgcagcg     1920

tctggcttta ccttcagctc ctttggcatg agctgggttc gccaggctcc gggaaaagga     1980

ctggaatggg tttcgtctat tagcggcagt ggtagcgata cgctctacgc ggactccgtg     2040

aagggccgtt tcaccatctc ccgcgataac gccaaaacta cactgtatct gcaaatgaat     2100

agcctgcgtc ctgaagatac ggccctgtat tactgtacta ttggtggctc gttaagccgt     2160

tcttcacagg gtaccctggt caccgtctcc tcagcg                               2196


<210>  153
<211>  732
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized lama

<400>  153

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Ala Ser Ile His 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Val Ile Thr Trp Ser Gly Gly Ile Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Gly Asp Lys His Gln Ser Ser Trp Tyr Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu 
145                 150                 155                 160 


Ser Gly Gly Gly Val Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
                165                 170                 175     


Ala Ala Ser Gly Ser Ile Ala Ser Ile His Ala Met Gly Trp Phe Arg 
            180                 185                 190         


Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ala Val Ile Thr Trp Ser 
        195                 200                 205             


Gly Gly Ile Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
    210                 215                 220                 


Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu 
225                 230                 235                 240 


Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Ala Gly Asp Lys His Gln 
                245                 250                 255     


Ser Ser Trp Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            260                 265                 270         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        275                 280                 285             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    290                 295                 300                 


Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val 
305                 310                 315                 320 


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr 
                325                 330                 335     


Phe Ser Phe Tyr Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu 
            340                 345                 350         


Arg Glu Phe Val Ala Asp Ile Arg Thr Ser Ala Gly Arg Thr Tyr Tyr 
        355                 360                 365             


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys 
    370                 375                 380                 


Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala 
385                 390                 395                 400 


Leu Tyr Tyr Cys Ala Ala Glu Pro Ser Gly Ile Ser Gly Trp Asp Tyr 
                405                 410                 415     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
            420                 425                 430         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        435                 440                 445             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
    450                 455                 460                 


Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly Ser Leu 
465                 470                 475                 480 


Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr Phe Ser Phe Tyr Gly Met 
                485                 490                 495     


Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ala Asp 
            500                 505                 510         


Ile Arg Thr Ser Ala Gly Arg Thr Tyr Tyr Ala Asp Ser Val Lys Gly 
        515                 520                 525             


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu Gln 
    530                 535                 540                 


Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Ala Ala 
545                 550                 555                 560 


Glu Pro Ser Gly Ile Ser Gly Trp Asp Tyr Trp Gly Gln Gly Thr Leu 
                565                 570                 575     


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
            580                 585                 590         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        595                 600                 605             


Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly 
    610                 615                 620                 


Gly Gly Val Val Gln Pro Gly Asn Ser Leu Arg Leu Ser Cys Ala Ala 
625                 630                 635                 640 


Ser Gly Phe Thr Phe Ser Ser Phe Gly Met Ser Trp Val Arg Gln Ala 
                645                 650                 655     


Pro Gly Lys Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Ser 
            660                 665                 670         


Asp Thr Leu Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
        675                 680                 685             


Asp Asn Ala Lys Thr Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro 
    690                 695                 700                 


Glu Asp Thr Ala Leu Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser Arg 
705                 710                 715                 720 


Ser Ser Gln Gly Thr Leu Val Thr Val Ser Ser Ala 
                725                 730         


<210>  154
<211>  11
<212>  PRT
<213>  Rattus

<400>  154

Lys Thr Ser Gln Asn Ile Phe Glu Asn Leu Ala 
1               5                   10      


<210>  155
<211>  7
<212>  PRT
<213>  Rattus

<400>  155

Asn Ala Ser Pro Leu Gln Ala 
1               5           


<210>  156
<211>  8
<212>  PRT
<213>  Rattus

<400>  156

His Gln Tyr Tyr Ser Gly Tyr Thr 
1               5               


<210>  157
<211>  10
<212>  PRT
<213>  Rattus

<400>  157

Gly Phe Thr Phe Ser Asp Tyr His Met Ala 
1               5                   10  


<210>  158
<211>  17
<212>  PRT
<213>  Rattus

<400>  158

Ser Ile Thr Leu Asp Ala Thr Tyr Thr Tyr Tyr Arg Asp Ser Val Arg 
1               5                   10                  15      


Gly 
    


<210>  159
<211>  10
<212>  PRT
<213>  Rattus

<400>  159

His Arg Gly Phe Ser Val Trp Leu Asp Tyr 
1               5                   10  


<210>  160
<211>  10
<212>  PRT
<213>  Rattus

<400>  160

Gly Tyr Ile Phe Thr Asp Tyr Ala Met His 
1               5                   10  


<210>  161
<211>  16
<212>  PRT
<213>  Rattus

<400>  161

Thr Phe Ile Pro Leu Leu Asp Thr Ser Asp Tyr Asn Gln Asn Phe Lys 
1               5                   10                  15      


<210>  162
<211>  11
<212>  PRT
<213>  Rattus

<400>  162

Met Gly Val Thr His Ser Tyr Val Met Asp Ala 
1               5                   10      


<210>  163
<211>  11
<212>  PRT
<213>  Rattus

<400>  163

Arg Ala Ser Gln Pro Ile Ser Ile Ser Val His 
1               5                   10      


<210>  164
<211>  7
<212>  PRT
<213>  Rattus

<400>  164

Phe Ala Ser Gln Ser Ile Ser 
1               5           


<210>  165
<211>  9
<212>  PRT
<213>  Rattus

<400>  165

Gln Gln Thr Phe Ser Leu Pro Tyr Thr 
1               5                   


<210>  166
<211>  10
<212>  PRT
<213>  Mus

<400>  166

Gly Phe Ile Ile Lys Ala Thr Tyr Met His 
1               5                   10  


<210>  167
<211>  17
<212>  PRT
<213>  Mus

<400>  167

Arg Ile Asp Pro Ala Asn Gly Glu Thr Lys Tyr Asp Pro Lys Phe Gln 
1               5                   10                  15      


Val 
    


<210>  168
<211>  7
<212>  PRT
<213>  Mus

<400>  168

Tyr Ala Trp Tyr Phe Asp Val 
1               5           


<210>  169
<211>  11
<212>  PRT
<213>  Mus

<400>  169

Arg Ala Ser Glu Asn Ile Tyr Ser Phe Leu Ala 
1               5                   10      


<210>  170
<211>  7
<212>  PRT
<213>  Mus

<400>  170

His Ala Lys Thr Leu Ala Glu 
1               5           


<210>  171
<211>  9
<212>  PRT
<213>  Mus

<400>  171

Gln His Tyr Tyr Gly Ser Pro Leu Thr 
1               5                   


<210>  172
<211>  447
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized mouse

<400>  172

Gln Val Gln Leu Val Gln Ser Gly Val Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Tyr Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Asn Pro Ser Asn Gly Gly Thr Asn Phe Asn Glu Lys Phe 
    50                  55                  60                  


Lys Asn Arg Val Thr Leu Thr Thr Asp Ser Ser Thr Thr Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Lys Ser Leu Gln Phe Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Asp Tyr Arg Phe Asp Met Gly Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro 
    210                 215                 220                 


Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 
            260                 265                 270         


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440                 445         


<210>  173
<211>  218
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized mouse

<400>  173

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Lys Gly Val Ser Thr Ser 
            20                  25                  30          


Gly Tyr Ser Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 
        35                  40                  45              


Arg Leu Leu Ile Tyr Leu Ala Ser Tyr Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln His Ser Arg 
                85                  90                  95      


Asp Leu Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 110         


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120                 125             


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    130                 135                 140                 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
145                 150                 155                 160 


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            180                 185                 190         


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
        195                 200                 205             


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215             


<210>  174
<211>  440
<212>  PRT
<213>  Homo sapiens

<400>  174

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Asp Cys Lys Ala Ser Gly Ile Thr Phe Ser Asn Ser 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Tyr Asp Gly Ser Lys Arg Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Asn Asp Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser 
        115                 120                 125             


Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
    130                 135                 140                 


Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
145                 150                 155                 160 


Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
                165                 170                 175     


Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys 
            180                 185                 190         


Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp 
        195                 200                 205             


Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala 
    210                 215                 220                 


Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
225                 230                 235                 240 


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
                245                 250                 255     


Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val 
            260                 265                 270         


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
        275                 280                 285             


Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
    290                 295                 300                 


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly 
305                 310                 315                 320 


Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
                325                 330                 335     


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr 
            340                 345                 350         


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
        355                 360                 365             


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
    370                 375                 380                 


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
385                 390                 395                 400 


Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe 
                405                 410                 415     


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
            420                 425                 430         


Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440 


<210>  175
<211>  214
<212>  PRT
<213>  Homo sapiens

<400>  175

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Ser Ser Asn Trp Pro Arg 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  176
<211>  153
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized Lama

<400>  176

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr Phe Ser Phe Tyr 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Asp Ile Arg Thr Ser Ala Gly Arg Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Glu Pro Ser Gly Ile Ser Gly Trp Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala Ala Ala Asp Tyr Lys Asp His Asp 
        115                 120                 125             


Gly Asp Tyr Lys Asp His Asp Ile Asp Tyr Lys Asp Asp Asp Asp Lys 
    130                 135                 140                 


Gly Ala Ala His His His His His His 
145                 150             


<210>  177
<211>  153
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized Lama

<400>  177

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr Phe Ser Phe Tyr 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Asp Ile Arg Thr Ser Ala Gly Arg Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Ser Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Glu Pro Ser Gly Ile Ser Gly Trp Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala Ala Ala Asp Tyr Lys Asp His Asp 
        115                 120                 125             


Gly Asp Tyr Lys Asp His Asp Ile Asp Tyr Lys Asp Asp Asp Asp Lys 
    130                 135                 140                 


Gly Ala Ala His His His His His His 
145                 150             


<210>  178
<211>  153
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized Lama

<400>  178

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr Phe Ser Phe Tyr 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Asp Ile Arg Thr Ser Ala Gly Arg Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Val Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Glu Pro Ser Gly Ile Ser Gly Trp Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala Ala Ala Asp Tyr Lys Asp His Asp 
        115                 120                 125             


Gly Asp Tyr Lys Asp His Asp Ile Asp Tyr Lys Asp Asp Asp Asp Lys 
    130                 135                 140                 


Gly Ala Ala His His His His His His 
145                 150             


<210>  179
<211>  153
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized Lama

<400>  179

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr Phe Ser Phe Tyr 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Asp Ile Arg Thr Ser Ala Gly Arg Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Gly Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Glu Pro Ser Gly Ile Ser Gly Trp Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala Ala Ala Asp Tyr Lys Asp His Asp 
        115                 120                 125             


Gly Asp Tyr Lys Asp His Asp Ile Asp Tyr Lys Asp Asp Asp Asp Lys 
    130                 135                 140                 


Gly Ala Ala His His His His His His 
145                 150             


<210>  180
<211>  153
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized Lama

<400>  180

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr Phe Ser Phe Tyr 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Asp Ile Arg Thr Ser Ala Gly Arg Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Arg Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Glu Pro Ser Gly Ile Ser Gly Trp Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala Ala Ala Asp Tyr Lys Asp His Asp 
        115                 120                 125             


Gly Asp Tyr Lys Asp His Asp Ile Asp Tyr Lys Asp Asp Asp Asp Lys 
    130                 135                 140                 


Gly Ala Ala His His His His His His 
145                 150             


<210>  181
<211>  153
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized Lama

<400>  181

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr Phe Ser Phe Tyr 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Asp Ile Arg Thr Ser Ala Gly Arg Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Gln Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Glu Pro Ser Gly Ile Ser Gly Trp Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala Ala Ala Asp Tyr Lys Asp His Asp 
        115                 120                 125             


Gly Asp Tyr Lys Asp His Asp Ile Asp Tyr Lys Asp Asp Asp Asp Lys 
    130                 135                 140                 


Gly Ala Ala His His His His His His 
145                 150             


<210>  182
<211>  153
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized Lama

<400>  182

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr Phe Ser Phe Tyr 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Asp Ile Arg Thr Ser Ala Gly Arg Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Met Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Glu Pro Ser Gly Ile Ser Gly Trp Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala Ala Ala Asp Tyr Lys Asp His Asp 
        115                 120                 125             


Gly Asp Tyr Lys Asp His Asp Ile Asp Tyr Lys Asp Asp Asp Asp Lys 
    130                 135                 140                 


Gly Ala Ala His His His His His His 
145                 150             


<210>  183
<211>  153
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized Lama

<400>  183

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr Phe Ser Phe Tyr 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Asp Ile Arg Thr Ser Ala Gly Arg Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp His Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Glu Pro Ser Gly Ile Ser Gly Trp Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala Ala Ala Asp Tyr Lys Asp His Asp 
        115                 120                 125             


Gly Asp Tyr Lys Asp His Asp Ile Asp Tyr Lys Asp Asp Asp Asp Lys 
    130                 135                 140                 


Gly Ala Ala His His His His His His 
145                 150             


<210>  184
<211>  153
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized Lama

<400>  184

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr Phe Ser Phe Tyr 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Asp Ile Arg Thr Ser Ala Gly Arg Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Thr Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Glu Pro Ser Gly Ile Ser Gly Trp Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala Ala Ala Asp Tyr Lys Asp His Asp 
        115                 120                 125             


Gly Asp Tyr Lys Asp His Asp Ile Asp Tyr Lys Asp Asp Asp Asp Lys 
    130                 135                 140                 


Gly Ala Ala His His His His His His 
145                 150             


<210>  185
<211>  153
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized Lama

<400>  185

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr Phe Ser Phe Tyr 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Asp Ile Arg Thr Ser Ala Gly Arg Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Glu Pro Ser Gly Ile Ser Gly Trp Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala Ala Ala Asp Tyr Lys Asp His Asp 
        115                 120                 125             


Gly Asp Tyr Lys Asp His Asp Ile Asp Tyr Lys Asp Asp Asp Asp Lys 
    130                 135                 140                 


Gly Ala Ala His His His His His His 
145                 150             


<210>  186
<211>  153
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized Lama

<400>  186

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr Phe Ser Phe Tyr 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Asp Ile Arg Thr Ser Ala Gly Arg Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Glu Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Glu Pro Ser Gly Ile Ser Gly Trp Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala Ala Ala Asp Tyr Lys Asp His Asp 
        115                 120                 125             


Gly Asp Tyr Lys Asp His Asp Ile Asp Tyr Lys Asp Asp Asp Asp Lys 
    130                 135                 140                 


Gly Ala Ala His His His His His His 
145                 150             


<210>  187
<211>  153
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized Lama

<400>  187

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr Phe Ser Phe Tyr 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Asp Ile Arg Thr Ser Ala Gly Arg Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Trp Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Glu Pro Ser Gly Ile Ser Gly Trp Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala Ala Ala Asp Tyr Lys Asp His Asp 
        115                 120                 125             


Gly Asp Tyr Lys Asp His Asp Ile Asp Tyr Lys Asp Asp Asp Asp Lys 
    130                 135                 140                 


Gly Ala Ala His His His His His His 
145                 150             


<210>  188
<211>  153
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized Lama

<400>  188

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr Phe Ser Phe Tyr 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Asp Ile Arg Thr Ser Ala Gly Arg Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Phe Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Glu Pro Ser Gly Ile Ser Gly Trp Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala Ala Ala Asp Tyr Lys Asp His Asp 
        115                 120                 125             


Gly Asp Tyr Lys Asp His Asp Ile Asp Tyr Lys Asp Asp Asp Asp Lys 
    130                 135                 140                 


Gly Ala Ala His His His His His His 
145                 150             


<210>  189
<211>  153
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized Lama

<400>  189

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr Phe Ser Phe Tyr 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Asp Ile Arg Thr Ser Ala Gly Arg Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Lys Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Glu Pro Ser Gly Ile Ser Gly Trp Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala Ala Ala Asp Tyr Lys Asp His Asp 
        115                 120                 125             


Gly Asp Tyr Lys Asp His Asp Ile Asp Tyr Lys Asp Asp Asp Asp Lys 
    130                 135                 140                 


Gly Ala Ala His His His His His His 
145                 150             


<210>  190
<211>  153
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized Lama

<400>  190

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr Phe Ser Phe Tyr 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Asp Ile Arg Thr Ser Ala Gly Arg Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Ala Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Glu Pro Ser Gly Ile Ser Gly Trp Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala Ala Ala Asp Tyr Lys Asp His Asp 
        115                 120                 125             


Gly Asp Tyr Lys Asp His Asp Ile Asp Tyr Lys Asp Asp Asp Asp Lys 
    130                 135                 140                 


Gly Ala Ala His His His His His His 
145                 150             


<210>  191
<211>  153
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized Lama

<400>  191

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr Phe Ser Phe Tyr 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Asp Ile Arg Thr Ser Ala Gly Arg Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Tyr Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Glu Pro Ser Gly Ile Ser Gly Trp Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala Ala Ala Asp Tyr Lys Asp His Asp 
        115                 120                 125             


Gly Asp Tyr Lys Asp His Asp Ile Asp Tyr Lys Asp Asp Asp Asp Lys 
    130                 135                 140                 


Gly Ala Ala His His His His His His 
145                 150             


<210>  192
<211>  153
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized Lama

<400>  192

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr Phe Ser Phe Tyr 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Asp Ile Arg Thr Ser Ala Gly Arg Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Pro Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Glu Pro Ser Gly Ile Ser Gly Trp Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala Ala Ala Asp Tyr Lys Asp His Asp 
        115                 120                 125             


Gly Asp Tyr Lys Asp His Asp Ile Asp Tyr Lys Asp Asp Asp Asp Lys 
    130                 135                 140                 


Gly Ala Ala His His His His His His 
145                 150             


<210>  193
<211>  424
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized Lama

<400>  193

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr Phe Ser Phe Tyr 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Asp Ile Arg Thr Ser Ala Gly Arg Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Glu Pro Ser Gly Ile Ser Gly Trp Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu 
145                 150                 155                 160 


Ser Gly Gly Gly Val Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
                165                 170                 175     


Ala Ala Ser Gly Gly Thr Phe Ser Phe Tyr Gly Met Gly Trp Phe Arg 
            180                 185                 190         


Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ala Asp Ile Arg Thr Ser 
        195                 200                 205             


Ala Gly Arg Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
    210                 215                 220                 


Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu 
225                 230                 235                 240 


Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Ala Ala Glu Pro Ser Gly 
                245                 250                 255     


Ile Ser Gly Trp Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            260                 265                 270         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        275                 280                 285             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    290                 295                 300                 


Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val 
305                 310                 315                 320 


Gln Pro Gly Asn Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr 
                325                 330                 335     


Phe Ser Ser Phe Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly 
            340                 345                 350         


Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr 
        355                 360                 365             


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys 
    370                 375                 380                 


Thr Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala 
385                 390                 395                 400 


Leu Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly 
                405                 410                 415     


Thr Leu Val Thr Val Ser Ser Ala 
            420                 


<210>  194
<211>  270
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized Lama

<400>  194

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr Phe Ser Phe Tyr 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Asp Ile Arg Thr Ser Ala Gly Arg Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Glu Pro Ser Gly Ile Ser Gly Trp Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu 
145                 150                 155                 160 


Ser Gly Gly Gly Val Val Gln Pro Gly Asn Ser Leu Arg Leu Ser Cys 
                165                 170                 175     


Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe Gly Met Ser Trp Val Arg 
            180                 185                 190         


Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser 
        195                 200                 205             


Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
    210                 215                 220                 


Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr Leu Gln Met Asn Ser Leu 
225                 230                 235                 240 


Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Thr Ile Gly Gly Ser Leu 
                245                 250                 255     


Ser Arg Ser Ser Gln Gly Thr Leu Val Thr Val Ser Ser Ala 
            260                 265                 270 


<210>  195
<211>  138
<212>  PRT
<213>  Homo sapiens

<400>  195

Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly 
1               5                   10                  15      


Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr Glu 
            20                  25                  30          


Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val 
        35                  40                  45              


Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp Asp 
    50                  55                  60                  


Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile 
65                  70                  75                  80  


Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu 
                85                  90                  95      


Leu Met Tyr Pro Pro Pro Tyr Tyr Leu Gly Ile Gly Asn Gly Thr Gln 
            100                 105                 110         


Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp Phe His His 
        115                 120                 125             


His His His His His His His Gly Gly Gln 
    130                 135             


<210>  196
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized Lama


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X is E or D

<220>
<221>  MISC_FEATURE
<222>  (74)..(74)
<223>  X is S, V, G, R, Q, M, H, T, D, E, W, F, K, A, Y or P

<400>  196

Xaa Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr Phe Ser Phe Tyr 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Asp Ile Arg Thr Ser Ala Gly Arg Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Xaa Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Glu Pro Ser Gly Ile Ser Gly Trp Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  197
<211>  223
<212>  PRT
<213>  Homo sapiens


<220>
<221>  mat_peptide
<222>  (36)..(223)

<400>  197

Met Ala Cys Leu Gly Phe Gln Arg His Lys Ala Gln Leu Asn Leu Ala 
-35                 -30                 -25                 -20 


Thr Arg Thr Trp Pro Cys Thr Leu Leu Phe Phe Leu Leu Phe Ile Pro 
                -15                 -10                 -5      


Val Phe Cys Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala 
        -1  1               5                   10              


Ser Ser Arg Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly 
    15                  20                  25                  


Lys Ala Thr Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln 
30                  35                  40                  45  


Val Thr Glu Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr 
                50                  55                  60      


Phe Leu Asp Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val 
            65                  70                  75          


Asn Leu Thr Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile 
        80                  85                  90              


Cys Lys Val Glu Leu Met Tyr Pro Pro Pro Tyr Tyr Leu Gly Ile Gly 
    95                  100                 105                 


Asn Gly Thr Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser 
110                 115                 120                 125 


Asp Phe Leu Leu Trp Ile Leu Ala Ala Val Ser Ser Gly Leu Phe Phe 
                130                 135                 140     


Tyr Ser Phe Leu Leu Thr Ala Val Ser Leu Ser Lys Met Leu Lys Lys 
            145                 150                 155         


Arg Ser Pro Leu Thr Thr Gly Val Tyr Val Lys Met Pro Pro Thr Glu 
        160                 165                 170             


Pro Glu Cys Glu Lys Gln Phe Gln Pro Tyr Phe Ile Pro Ile Asn 
    175                 180                 185             


<210>  198
<211>  288
<212>  PRT
<213>  Homo sapiens


<220>
<221>  mat_peptide
<222>  (21)..(288)

<400>  198

Met Gln Ile Pro Gln Ala Pro Trp Pro Val Val Trp Ala Val Leu Gln 
-20                 -15                 -10                 -5  


Leu Gly Trp Arg Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp 
            -1  1               5                   10          


Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp 
        15                  20                  25              


Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val 
    30                  35                  40                  


Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala 
45                  50                  55                  60  


Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg 
                65                  70                  75      


Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg 
            80                  85                  90          


Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu 
        95                  100                 105             


Ala Pro Lys Ala Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val 
    110                 115                 120                 


Thr Glu Arg Arg Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro 
125                 130                 135                 140 


Arg Pro Ala Gly Gln Phe Gln Thr Leu Val Val Gly Val Val Gly Gly 
                145                 150                 155     


Leu Leu Gly Ser Leu Val Leu Leu Val Trp Val Leu Ala Val Ile Cys 
            160                 165                 170         


Ser Arg Ala Ala Arg Gly Thr Ile Gly Ala Arg Arg Thr Gly Gln Pro 
        175                 180                 185             


Leu Lys Glu Asp Pro Ser Ala Val Pro Val Phe Ser Val Asp Tyr Gly 
    190                 195                 200                 


Glu Leu Asp Phe Gln Trp Arg Glu Lys Thr Pro Glu Pro Pro Val Pro 
205                 210                 215                 220 


Cys Val Pro Glu Gln Thr Glu Tyr Ala Thr Ile Val Phe Pro Ser Gly 
                225                 230                 235     


Met Gly Thr Ser Ser Pro Ala Arg Arg Gly Ser Ala Asp Gly Pro Arg 
            240                 245                 250         


Ser Ala Gln Pro Leu Arg Pro Glu Asp Gly His Cys Ser Trp Pro Leu 
        255                 260                 265             


<210>  199
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Lama Sp.

<400>  199

Gly Phe Thr Phe Ser Ser Phe Gly Met Ser 
1               5                   10  


<210>  200
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Lama Sp.

<400>  200

Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  201
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Lama  Sp.

<400>  201

Gly Gly Ser Leu Ser Arg 
1               5       


