                         SEQUENCE LISTING

<110>  Bayer Healthcare, LLC
 
<120>  OPTIMIZED HUMANIZED MONOCLONAL ANTIBODIES AGAINST ACTIVATED 
       PROTEIN C AND USES THEREOF

<130>  BAOM.P0133WO

<140> 	Not Yet Assigned
<141>	2016-11-15

<150>  62/256,582
<151>  2015-11-17

<160>  84    

<170>  PatentIn version 3.5

<210>  1
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  1

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Tyr Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asp Ile Arg Leu Lys Ser Asn Asn Tyr Glu Lys His Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Arg Glu Gly Asp Tyr Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  2
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  2

Ser Tyr Tyr Met Asn 
1               5   


<210>  3
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  3

Asp Ile Arg Leu Lys Ser Asn Asn Tyr Glu Lys His Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Gly 
            


<210>  4
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  4

Ala Arg Glu Gly Asp Tyr Phe Asp Tyr 
1               5                   


<210>  5
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  5

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Pro Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Thr Cys Arg Ala Ser Glu Ser Val Asp Ser Phe 
            20                  25                  30          


Gly Ala Thr Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn 
65                  70                  75                  80  


Pro Val Glu Ala Asn Asp Thr Ala Asn Tyr Tyr Cys Gln Gln Asn Asn 
                85                  90                  95      


Glu Asp Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  6
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  6

Arg Ala Ser Glu Ser Val Asp Ser Phe Gly Ala Thr Phe Met His 
1               5                   10                  15  


<210>  7
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  7

Leu Ala Ser Asn Leu Glu Ser 
1               5           


<210>  8
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  8

Gln Gln Asn Asn Glu Asp Pro Tyr Thr 
1               5                   


<210>  9
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleic acid

<400>  9
gaagtgcagc tggtggaatc cggcggaggc ctggtgcagc ctggcggatc tctgagactg       60

tcttgtgccg cctccggctt caccttctcc agctactaca tgaactgggt gcgacaggcc      120

cctggcaagg gcctggaatg ggtggccgac atccggctga agtccaacaa ctacgagaag      180

cactacgccg actccgtgaa gggccggttc accatcagcc gggacaacgc caagaactcc      240

ctgtacctgc agatgaacag cctgcgggcc gaggacaccg ccgtgtacta ctgtgctaga      300

gagggcgact acttcgacta ctggggccag ggcacactcg tgaccgtcag ctca            354


<210>  10
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleic acid

<400>  10
gatatcgtgc tgacccagtc tcctgcctcc ctggctgtgt ctcctggcca gagagccacc       60

atcacctgtc gggcctctga gtccgtggac tctttcggcg ccaccttcat gcactggtat      120

cagcagaagc ccggccagcc ccccaagctg ctgatctacc tggcctccaa cctggaatcc      180

ggcgtgcccg ccagattctc cggctctggc tctggcaccg acttcaccct gaccatcaac      240

cccgtggaag ccaacgacac cgccaactac tactgccagc agaacaacga ggacccctac      300

accttcggcc agggcaccaa gctggaaatc aag                                   333


<210>  11
<211>  443
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  11

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Tyr Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asp Ile Arg Leu Lys Ser Asn Asn Tyr Glu Lys His Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Arg Glu Gly Asp Tyr Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Thr Val Glu Arg Lys Cys Cys Val Glu Cys 
    210                 215                 220                 


Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe 
225                 230                 235                 240 


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
                245                 250                 255     


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe 
            260                 265                 270         


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
        275                 280                 285             


Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr 
    290                 295                 300                 


Val Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
305                 310                 315                 320 


Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr 
                325                 330                 335     


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
            340                 345                 350         


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
        355                 360                 365             


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
    370                 375                 380                 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser 
385                 390                 395                 400 


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
                405                 410                 415     


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
            420                 425                 430         


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440             


<210>  12
<211>  218
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  12

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Pro Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Thr Cys Arg Ala Ser Glu Ser Val Asp Ser Phe 
            20                  25                  30          


Gly Ala Thr Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn 
65                  70                  75                  80  


Pro Val Glu Ala Asn Asp Thr Ala Asn Tyr Tyr Cys Gln Gln Asn Asn 
                85                  90                  95      


Glu Asp Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 110         


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120                 125             


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    130                 135                 140                 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
145                 150                 155                 160 


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            180                 185                 190         


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
        195                 200                 205             


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215             


<210>  13
<211>  1329
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleic acid

<400>  13
gaagtgcagc tggtggaatc cggcggaggc ctggtgcagc ctggcggatc tctgagactg       60

tcttgtgccg cctccggctt caccttctcc agctactaca tgaactgggt gcgacaggcc      120

cctggcaagg gcctggaatg ggtggccgac atccggctga agtccaacaa ctacgagaag      180

cactacgccg actccgtgaa gggccggttc accatcagcc gggacaacgc caagaactcc      240

ctgtacctgc agatgaacag cctgcgggcc gaggacaccg ccgtgtacta ctgtgctaga      300

gagggcgact acttcgacta ctggggccag ggcacactcg tgaccgtcag ctcagcttcc      360

accaagggcc cctccgtgtt ccctctggcc ccttgctccc ggtccacctc tgagtctacc      420

gccgctctgg gctgcctggt gaaagactac ttccccgagc ccgtgaccgt gtcctggaac      480

tctggcgccc tgacctccgg cgtgcacacc tttccagccg tgctgcagtc ctccggcctg      540

tactccctgt cctccgtggt gacagtgccc tcctccaact tcggcaccca gacctacacc      600

tgtaacgtgg accacaagcc ctccaacacc aaggtggaca agaccgtgga acggaagtgc      660

tgcgtggaat gcccaccctg tcctgctcca cctgtggctg gccccagcgt gttcctgttc      720

cccccaaagc ccaaggacac cctgatgatc tcccggaccc ccgaagtgac ctgcgtggtg      780

gtggacgtgt cccacgagga ccccgaggtg cagttcaatt ggtacgtgga cggcgtggaa      840

gtgcacaacg ccaagaccaa gcccagagag gaacagttca actccacctt ccgggtggtg      900

tccgtgctga ccgtggtgca tcaggactgg ctgaacggca aagagtacaa gtgcaaggtc      960

tccaacaagg gcctgcctgc ccccatcgaa aagaccatca gcaagaccaa gggccagccc     1020

cgcgagcccc aggtgtacac actgcccccc agccgggaag agatgaccaa gaaccaggtg     1080

tccctgacct gtctggtgaa aggcttctac ccctccgaca ttgccgtgga atgggagtcc     1140

aacggacagc ctgagaacaa ctacaagacc acccccccca tgctggactc cgacggctca     1200

ttcttcctgt actccaagct gacagtggac aagtcccggt ggcagcaggg caacgtgttc     1260

tcctgctccg tgatgcacga ggccctgcac aaccactaca cccagaagtc cctgtccctg     1320

agccccggc                                                             1329


<210>  14
<211>  654
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleic acid

<400>  14
gatatcgtgc tgacccagtc tcctgcctcc ctggctgtgt ctcctggcca gagagccacc       60

atcacctgtc gggcctctga gtccgtggac tctttcggcg ccaccttcat gcactggtat      120

cagcagaagc ccggccagcc ccccaagctg ctgatctacc tggcctccaa cctggaatcc      180

ggcgtgcccg ccagattctc cggctctggc tctggcaccg acttcaccct gaccatcaac      240

cccgtggaag ccaacgacac cgccaactac tactgccagc agaacaacga ggacccctac      300

accttcggcc agggcaccaa gctggaaatc aagcggaccg tggccgctcc ctccgtgttt      360

atcttcccac cctccgacga gcagctgaag tccggcacag cttccgtcgt gtgcctgctg      420

aacaacttct accctcggga agccaaggtg cagtggaagg tggacaacgc cctgcagtcc      480

ggcaactccc aggaatccgt gaccgagcag gactccaagg acagcaccta ctccctgtcc      540

tctaccctga ccctgtccaa ggccgactac gagaagcaca aggtgtacgc ctgcgaagtg      600

acccaccagg gcctgtctag ccccgtgacc aagtctttca accggggcga gtgt            654


<210>  15
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  15

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Tyr Leu Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Asp Ile Arg Leu Lys Ser Asn Asn Tyr Glu Lys His Tyr Ala Glu 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Ser 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Arg Glu Gly Asp Tyr Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  16
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  16

Asn Tyr Tyr Leu Asn 
1               5   


<210>  17
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  17

Asp Ile Arg Leu Lys Ser Asn Asn Tyr Glu Lys His Tyr Ala Glu Ser 
1               5                   10                  15      


Val Lys Gly 
            


<210>  18
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  18

Ala Arg Glu Gly Asp Tyr Phe Asp Tyr 
1               5                   


<210>  19
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  19

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Pro Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Thr Cys Lys Ala Ser Glu Ser Val Asp Ser Phe 
            20                  25                  30          


Gly Ala Thr Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn 
65                  70                  75                  80  


Pro Val Glu Ala Asn Asp Thr Ala Asn Tyr Tyr Cys Gln Gln Asn Asn 
                85                  90                  95      


Glu Asp Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  20
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  20

Lys Ala Ser Glu Ser Val Asp Ser Phe Gly Ala Thr Phe Met His 
1               5                   10                  15  


<210>  21
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  21

Leu Ala Ser Asn Leu Glu Ser 
1               5           


<210>  22
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  22

Gln Gln Asn Asn Glu Asp Pro Tyr Thr 
1               5                   


<210>  23
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleic acid

<400>  23
gaagtgcagc tggtggaatc cggcggaggc ctggtgcagc ctggcggatc tctgagactg       60

tcttgtgccg cctccggctt caccttctcc aactactacc tgaactgggt gcgacaggcc      120

cctggcaagg gactggaatg ggtgggagac atccggctga agtccaacaa ctacgagaag      180

cactacgccg agtccgtgaa gggccggttc accatctctc gggacgactc caagaactcc      240

ctgtacctgc agatgaacag cctgaaaacc gaggacaccg ccgtgtacta ctgcgccaga      300

gagggcgact acttcgacta ctggggccag ggcacactcg tgaccgtcag ctca            354


<210>  24
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleic acid

<400>  24
gatatcgtgc tgacccagtc tcctgcctcc ctggctgtgt ctcctggcca gagagccacc       60

attacctgca aggcctccga gtccgtggac tccttcggcg ccaccttcat gcactggtat      120

cagcagaagc ccggccagcc ccccaagctg ctgatctacc tggcctccaa cctggaatcc      180

ggcgtgcccg ccagattctc cggctctggc tctggcaccg acttcaccct gaccatcaac      240

cccgtggaag ccaacgacac cgccaactac tactgccagc agaacaacga ggacccctac      300

accttcggcc agggcaccaa gctggaaatc aag                                   333


<210>  25
<211>  443
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  25

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Tyr Leu Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Asp Ile Arg Leu Lys Ser Asn Asn Tyr Glu Lys His Tyr Ala Glu 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Ser 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Arg Glu Gly Asp Tyr Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Thr Val Glu Arg Lys Cys Cys Val Glu Cys 
    210                 215                 220                 


Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe 
225                 230                 235                 240 


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
                245                 250                 255     


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe 
            260                 265                 270         


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
        275                 280                 285             


Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr 
    290                 295                 300                 


Val Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
305                 310                 315                 320 


Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr 
                325                 330                 335     


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
            340                 345                 350         


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
        355                 360                 365             


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
    370                 375                 380                 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser 
385                 390                 395                 400 


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
                405                 410                 415     


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
            420                 425                 430         


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440             


<210>  26
<211>  218
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  26

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Pro Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Thr Cys Lys Ala Ser Glu Ser Val Asp Ser Phe 
            20                  25                  30          


Gly Ala Thr Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn 
65                  70                  75                  80  


Pro Val Glu Ala Asn Asp Thr Ala Asn Tyr Tyr Cys Gln Gln Asn Asn 
                85                  90                  95      


Glu Asp Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 110         


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120                 125             


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    130                 135                 140                 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
145                 150                 155                 160 


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            180                 185                 190         


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
        195                 200                 205             


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215             


<210>  27
<211>  1329
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleic acid

<400>  27
gaagtgcagc tggtggaatc cggcggaggc ctggtgcagc ctggcggatc tctgagactg       60

tcttgtgccg cctccggctt caccttctcc aactactacc tgaactgggt gcgacaggcc      120

cctggcaagg gactggaatg ggtgggagac atccggctga agtccaacaa ctacgagaag      180

cactacgccg agtccgtgaa gggccggttc accatctctc gggacgactc caagaactcc      240

ctgtacctgc agatgaacag cctgaaaacc gaggacaccg ccgtgtacta ctgcgccaga      300

gagggcgact acttcgacta ctggggccag ggcacactcg tgaccgtcag ctcagcttcc      360

accaagggcc cctccgtgtt ccctctggcc ccttgctccc ggtccacctc tgagtctacc      420

gccgctctgg gctgcctggt gaaagactac ttccccgagc ccgtgaccgt gtcctggaac      480

tctggcgccc tgacctccgg cgtgcacacc tttccagccg tgctgcagtc ctccggcctg      540

tactccctgt cctccgtggt gacagtgccc tcctccaact tcggcaccca gacctacacc      600

tgtaacgtgg accacaagcc ctccaacacc aaggtggaca agaccgtgga acggaagtgc      660

tgcgtggaat gcccaccctg tcctgctcca cctgtggctg gccccagcgt gttcctgttc      720

cccccaaagc ccaaggacac cctgatgatc tcccggaccc ccgaagtgac ctgcgtggtg      780

gtggacgtgt cccacgagga ccccgaggtg cagttcaatt ggtacgtgga cggcgtggaa      840

gtgcacaacg ccaagaccaa gcccagagag gaacagttca actccacctt ccgggtggtg      900

tccgtgctga ccgtggtgca tcaggactgg ctgaacggca aagagtacaa gtgcaaggtc      960

tccaacaagg gcctgcctgc ccccatcgaa aagaccatca gcaagaccaa gggccagccc     1020

cgcgagcccc aggtgtacac actgcccccc agccgggaag agatgaccaa gaaccaggtg     1080

tccctgacct gtctggtgaa aggcttctac ccctccgaca ttgccgtgga atgggagtcc     1140

aacggacagc ctgagaacaa ctacaagacc acccccccca tgctggactc cgacggctca     1200

ttcttcctgt actccaagct gacagtggac aagtcccggt ggcagcaggg caacgtgttc     1260

tcctgctccg tgatgcacga ggccctgcac aaccactaca cccagaagtc cctgtccctg     1320

agccccggc                                                             1329


<210>  28
<211>  654
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleic acid

<400>  28
gatatcgtgc tgacccagtc tcctgcctcc ctggctgtgt ctcctggcca gagagccacc       60

attacctgca aggcctccga gtccgtggac tccttcggcg ccaccttcat gcactggtat      120

cagcagaagc ccggccagcc ccccaagctg ctgatctacc tggcctccaa cctggaatcc      180

ggcgtgcccg ccagattctc cggctctggc tctggcaccg acttcaccct gaccatcaac      240

cccgtggaag ccaacgacac cgccaactac tactgccagc agaacaacga ggacccctac      300

accttcggcc agggcaccaa gctggaaatc aagcggaccg tggccgctcc ctccgtgttt      360

atcttcccac cctccgacga gcagctgaag tccggcacag cttccgtcgt gtgcctgctg      420

aacaacttct accctcggga agccaaggtg cagtggaagg tggacaacgc cctgcagtcc      480

ggcaactccc aggaatccgt gaccgagcag gactccaagg acagcaccta ctccctgtcc      540

tctaccctga ccctgtccaa ggccgactac gagaagcaca aggtgtacgc ctgcgaagtg      600

acccaccagg gcctgtctag ccccgtgacc aagtctttca accggggcga gtgt            654


<210>  29
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  29

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Tyr Leu Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asp Ile Lys Ser Asn Asn Tyr Glu Lys His Tyr Ala Glu Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gly Asp Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  30
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  30

Asn Tyr Tyr Leu Asn 
1               5   


<210>  31
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  31

Asp Ile Lys Ser Asn Asn Tyr Glu Lys His Tyr Ala Glu Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  32
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  32

Ala Arg Glu Gly Asp Tyr Phe Asp Tyr 
1               5                   


<210>  33
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  33

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Pro Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Thr Cys Lys Ala Ser Glu Ser Val Asp Ser Phe 
            20                  25                  30          


Gly Ala Thr Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn 
65                  70                  75                  80  


Pro Val Glu Ala Asn Asp Thr Ala Asn Tyr Tyr Cys Gln Gln Asn Asn 
                85                  90                  95      


Glu Asp Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  34
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  34

Lys Ala Ser Glu Ser Val Asp Ser Phe Gly Ala Thr Phe Met His 
1               5                   10                  15  


<210>  35
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  35

Leu Ala Ser Asn Leu Glu Ser 
1               5           


<210>  36
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  36

Gln Gln Asn Asn Glu Asp Pro Tyr Thr 
1               5                   


<210>  37
<211>  348
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleic acid

<400>  37
gaagtgcagc tggtggaatc cggcggaggc ctggtgcagc ctggcggatc tctgagactg       60

tcttgtgccg cctccggctt caccttctcc aactactacc tgaactgggt gcgacaggcc      120

cctggcaagg gactggaatg ggtggccgac atcaagtcca acaactacga gaagcactac      180

gccgagtccg tgaagggccg gttcaccatc agccgggaca acgccaagaa ctccctgtac      240

ctgcagatga acagcctgcg ggccgaggac accgccgtgt actactgtgc tagagagggc      300

gactacttcg actactgggg ccagggcaca ctcgtgaccg tcagctca                   348


<210>  38
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleic acid

<400>  38
gatatcgtgc tgacccagtc tcctgcctcc ctggctgtgt ctcctggcca gagagccacc       60

attacctgca aggcctccga gtccgtggac tccttcggcg ccaccttcat gcactggtat      120

cagcagaagc ccggccagcc ccccaagctg ctgatctacc tggcctccaa cctggaatcc      180

ggcgtgcccg ccagattctc cggctctggc tctggcaccg acttcaccct gaccatcaac      240

cccgtggaag ccaacgacac cgccaactac tactgccagc agaacaacga ggacccctac      300

accttcggcc agggcaccaa gctggaaatc aag                                   333


<210>  39
<211>  441
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  39

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Tyr Leu Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asp Ile Lys Ser Asn Asn Tyr Glu Lys His Tyr Ala Glu Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gly Asp Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe 
            180                 185                 190         


Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro 
    210                 215                 220                 


Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro 
225                 230                 235                 240 


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
                245                 250                 255     


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp 
            260                 265                 270         


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
        275                 280                 285             


Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val 
    290                 295                 300                 


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
305                 310                 315                 320 


Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly 
                325                 330                 335     


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
            340                 345                 350         


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
        355                 360                 365             


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
    370                 375                 380                 


Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe 
385                 390                 395                 400 


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
                405                 410                 415     


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
            420                 425                 430         


Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440     


<210>  40
<211>  218
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  40

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Pro Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Thr Cys Lys Ala Ser Glu Ser Val Asp Ser Phe 
            20                  25                  30          


Gly Ala Thr Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn 
65                  70                  75                  80  


Pro Val Glu Ala Asn Asp Thr Ala Asn Tyr Tyr Cys Gln Gln Asn Asn 
                85                  90                  95      


Glu Asp Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 110         


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120                 125             


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    130                 135                 140                 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
145                 150                 155                 160 


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            180                 185                 190         


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
        195                 200                 205             


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215             


<210>  41
<211>  1323
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleic acid

<400>  41
gaagtgcagc tggtggaatc cggcggaggc ctggtgcagc ctggcggatc tctgagactg       60

tcttgtgccg cctccggctt caccttctcc aactactacc tgaactgggt gcgacaggcc      120

cctggcaagg gactggaatg ggtggccgac atcaagtcca acaactacga gaagcactac      180

gccgagtccg tgaagggccg gttcaccatc agccgggaca acgccaagaa ctccctgtac      240

ctgcagatga acagcctgcg ggccgaggac accgccgtgt actactgtgc tagagagggc      300

gactacttcg actactgggg ccagggcaca ctcgtgaccg tcagctcagc ttccaccaag      360

ggcccctccg tgttccctct ggccccttgc tcccggtcca cctctgagtc taccgccgct      420

ctgggctgcc tggtgaaaga ctacttcccc gagcccgtga ccgtgtcctg gaactctggc      480

gccctgacct ccggcgtgca cacctttcca gccgtgctgc agtcctccgg cctgtactcc      540

ctgtcctccg tggtgacagt gccctcctcc aacttcggca cccagaccta cacctgtaac      600

gtggaccaca agccctccaa caccaaggtg gacaagaccg tggaacggaa gtgctgcgtg      660

gaatgcccac cctgtcctgc tccacctgtg gctggcccca gcgtgttcct gttcccccca      720

aagcccaagg acaccctgat gatctcccgg acccccgaag tgacctgcgt ggtggtggac      780

gtgtcccacg aggaccccga ggtgcagttc aattggtacg tggacggcgt ggaagtgcac      840

aacgccaaga ccaagcccag agaggaacag ttcaactcca ccttccgggt ggtgtccgtg      900

ctgaccgtgg tgcatcagga ctggctgaac ggcaaagagt acaagtgcaa ggtctccaac      960

aagggcctgc ctgcccccat cgaaaagacc atcagcaaga ccaagggcca gccccgcgag     1020

ccccaggtgt acacactgcc ccccagccgg gaagagatga ccaagaacca ggtgtccctg     1080

acctgtctgg tgaaaggctt ctacccctcc gacattgccg tggaatggga gtccaacgga     1140

cagcctgaga acaactacaa gaccaccccc cccatgctgg actccgacgg ctcattcttc     1200

ctgtactcca agctgacagt ggacaagtcc cggtggcagc agggcaacgt gttctcctgc     1260

tccgtgatgc acgaggccct gcacaaccac tacacccaga agtccctgtc cctgagcccc     1320

ggc                                                                   1323


<210>  42
<211>  654
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleic acid

<400>  42
gatatcgtgc tgacccagtc tcctgcctcc ctggctgtgt ctcctggcca gagagccacc       60

attacctgca aggcctccga gtccgtggac tccttcggcg ccaccttcat gcactggtat      120

cagcagaagc ccggccagcc ccccaagctg ctgatctacc tggcctccaa cctggaatcc      180

ggcgtgcccg ccagattctc cggctctggc tctggcaccg acttcaccct gaccatcaac      240

cccgtggaag ccaacgacac cgccaactac tactgccagc agaacaacga ggacccctac      300

accttcggcc agggcaccaa gctggaaatc aagcggaccg tggccgctcc ctccgtgttt      360

atcttcccac cctccgacga gcagctgaag tccggcacag cttccgtcgt gtgcctgctg      420

aacaacttct accctcggga agccaaggtg cagtggaagg tggacaacgc cctgcagtcc      480

ggcaactccc aggaatccgt gaccgagcag gactccaagg acagcaccta ctccctgtcc      540

tctaccctga ccctgtccaa ggccgactac gagaagcaca aggtgtacgc ctgcgaagtg      600

acccaccagg gcctgtctag ccccgtgacc aagtctttca accggggcga gtgt            654


<210>  43
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  43

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Tyr Leu Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asp Ile Arg Leu Lys Ser Asn Asn Tyr Glu Lys His Tyr Ala Glu 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Ser 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ile Arg Glu Gly Asp Tyr Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser 
        115             


<210>  44
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  44

Asn Tyr Tyr Leu Asn 
1               5   


<210>  45
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  45

Asp Ile Arg Leu Lys Ser Asn Asn Tyr Glu Lys His Tyr Ala Glu Ser 
1               5                   10                  15      


Val Lys Gly 
            


<210>  46
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  46

Ile Arg Glu Gly Asp Tyr Phe Asp Tyr 
1               5                   


<210>  47
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  47

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Pro Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Thr Cys Lys Ala Ser Glu Ser Val Asp Ser Phe 
            20                  25                  30          


Gly Ala Thr Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn 
65                  70                  75                  80  


Pro Val Glu Ala Asn Asp Thr Ala Asn Tyr Tyr Cys Gln Gln Asn Asn 
                85                  90                  95      


Glu Asp Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  48
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  48

Lys Ala Ser Glu Ser Val Asp Ser Phe Gly Ala Thr Phe Met His 
1               5                   10                  15  


<210>  49
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  49

Leu Ala Ser Asn Leu Glu Ser 
1               5           


<210>  50
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  50

Gln Gln Asn Asn Glu Asp Pro Tyr Thr 
1               5                   


<210>  51
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleic acid

<400>  51
gaagtgcagc tggtggaatc cggcggaggc ctggtgcagc ctggcggatc tctgagactg       60

tcttgtgccg cctccggctt caccttctcc aactactacc tgaactgggt gcgacaggcc      120

cctggcaagg gactggaatg ggtggccgac atccggctga agtccaacaa ctacgagaag      180

cactacgccg agtccgtgaa gggccggttc accatctctc gggacgactc caagaactcc      240

ctgtacctgc agatgaacag cctgaaaacc gaggacaccg ccgtgtacta ctgcatcaga      300

gagggcgact acttcgacta ctggggccag ggcaccaccg tgaccgtcag ctca            354


<210>  52
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleic acid

<400>  52
gatatcgtgc tgacccagtc tcctgcctcc ctggctgtgt ctcctggcca gagagccacc       60

attacctgca aggcctccga gtccgtggac tccttcggcg ccaccttcat gcactggtat      120

cagcagaagc ccggccagcc ccccaagctg ctgatctacc tggcctccaa cctggaatcc      180

ggcgtgcccg ccagattctc cggctctggc tctggcaccg acttcaccct gaccatcaac      240

cccgtggaag ccaacgacac cgccaactac tactgccagc agaacaacga ggacccctac      300

accttcggcc agggcaccaa gctggaaatc aag                                   333


<210>  53
<211>  443
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  53

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Tyr Leu Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asp Ile Arg Leu Lys Ser Asn Asn Tyr Glu Lys His Tyr Ala Glu 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Ser 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ile Arg Glu Gly Asp Tyr Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Thr Val Glu Arg Lys Cys Cys Val Glu Cys 
    210                 215                 220                 


Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe 
225                 230                 235                 240 


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
                245                 250                 255     


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe 
            260                 265                 270         


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
        275                 280                 285             


Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr 
    290                 295                 300                 


Val Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
305                 310                 315                 320 


Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr 
                325                 330                 335     


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
            340                 345                 350         


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
        355                 360                 365             


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
    370                 375                 380                 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser 
385                 390                 395                 400 


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
                405                 410                 415     


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
            420                 425                 430         


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440             


<210>  54
<211>  218
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  54

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Pro Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Thr Cys Lys Ala Ser Glu Ser Val Asp Ser Phe 
            20                  25                  30          


Gly Ala Thr Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn 
65                  70                  75                  80  


Pro Val Glu Ala Asn Asp Thr Ala Asn Tyr Tyr Cys Gln Gln Asn Asn 
                85                  90                  95      


Glu Asp Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 110         


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120                 125             


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    130                 135                 140                 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
145                 150                 155                 160 


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            180                 185                 190         


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
        195                 200                 205             


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215             


<210>  55
<211>  1329
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleic acid

<400>  55
gaagtgcagc tggtggaatc cggcggaggc ctggtgcagc ctggcggatc tctgagactg       60

tcttgtgccg cctccggctt caccttctcc aactactacc tgaactgggt gcgacaggcc      120

cctggcaagg gactggaatg ggtggccgac atccggctga agtccaacaa ctacgagaag      180

cactacgccg agtccgtgaa gggccggttc accatctctc gggacgactc caagaactcc      240

ctgtacctgc agatgaacag cctgaaaacc gaggacaccg ccgtgtacta ctgcatcaga      300

gagggcgact acttcgacta ctggggccag ggcaccaccg tgaccgtcag ctcagcttcc      360

accaagggcc cctccgtgtt ccctctggcc ccttgctccc ggtccacctc tgagtctacc      420

gccgctctgg gctgcctggt gaaagactac ttccccgagc ccgtgaccgt gtcctggaac      480

tctggcgccc tgacctccgg cgtgcacacc tttccagccg tgctgcagtc ctccggcctg      540

tactccctgt cctccgtggt gacagtgccc tcctccaact tcggcaccca gacctacacc      600

tgtaacgtgg accacaagcc ctccaacacc aaggtggaca agaccgtgga acggaagtgc      660

tgcgtggaat gcccaccctg tcctgctcca cctgtggctg gccccagcgt gttcctgttc      720

cccccaaagc ccaaggacac cctgatgatc tcccggaccc ccgaagtgac ctgcgtggtg      780

gtggacgtgt cccacgagga ccccgaggtg cagttcaatt ggtacgtgga cggcgtggaa      840

gtgcacaacg ccaagaccaa gcccagagag gaacagttca actccacctt ccgggtggtg      900

tccgtgctga ccgtggtgca tcaggactgg ctgaacggca aagagtacaa gtgcaaggtc      960

tccaacaagg gcctgcctgc ccccatcgaa aagaccatca gcaagaccaa gggccagccc     1020

cgcgagcccc aggtgtacac actgcccccc agccgggaag agatgaccaa gaaccaggtg     1080

tccctgacct gtctggtgaa aggcttctac ccctccgaca ttgccgtgga atgggagtcc     1140

aacggacagc ctgagaacaa ctacaagacc acccccccca tgctggactc cgacggctca     1200

ttcttcctgt actccaagct gacagtggac aagtcccggt ggcagcaggg caacgtgttc     1260

tcctgctccg tgatgcacga ggccctgcac aaccactaca cccagaagtc cctgtccctg     1320

agccccggc                                                             1329


<210>  56
<211>  654
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleic acid

<400>  56
gatatcgtgc tgacccagtc tcctgcctcc ctggctgtgt ctcctggcca gagagccacc       60

attacctgca aggcctccga gtccgtggac tccttcggcg ccaccttcat gcactggtat      120

cagcagaagc ccggccagcc ccccaagctg ctgatctacc tggcctccaa cctggaatcc      180

ggcgtgcccg ccagattctc cggctctggc tctggcaccg acttcaccct gaccatcaac      240

cccgtggaag ccaacgacac cgccaactac tactgccagc agaacaacga ggacccctac      300

accttcggcc agggcaccaa gctggaaatc aagcggaccg tggccgctcc ctccgtgttt      360

atcttcccac cctccgacga gcagctgaag tccggcacag cttccgtcgt gtgcctgctg      420

aacaacttct accctcggga agccaaggtg cagtggaagg tggacaacgc cctgcagtcc      480

ggcaactccc aggaatccgt gaccgagcag gactccaagg acagcaccta ctccctgtcc      540

tctaccctga ccctgtccaa ggccgactac gagaagcaca aggtgtacgc ctgcgaagtg      600

acccaccagg gcctgtctag ccccgtgacc aagtctttca accggggcga gtgt            654


<210>  57
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  57

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Tyr Leu Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asp Ile Arg Leu Lys Ser Asn Asn Tyr Glu Lys His Tyr Ala Glu 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Ser 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ile Arg Glu Gly Asp Tyr Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser 
        115             


<210>  58
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  58

Asn Tyr Tyr Leu Asn 
1               5   


<210>  59
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  59

Asp Ile Arg Leu Lys Ser Asn Asn Tyr Glu Lys His Tyr Ala Glu Ser 
1               5                   10                  15      


Val Lys Gly 
            


<210>  60
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  60

Ile Arg Glu Gly Asp Tyr Phe Asp Tyr 
1               5                   


<210>  61
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  61

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ala Ser Glu Ser Val Asp Ser Phe 
            20                  25                  30          


Gly Ala Thr Phe Met His Trp Tyr Leu Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Gln Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser 
65                  70                  75                  80  


Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Gln Gln Asn Asn 
                85                  90                  95      


Glu Asp Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  62
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  62

Lys Ala Ser Glu Ser Val Asp Ser Phe Gly Ala Thr Phe Met His 
1               5                   10                  15  


<210>  63
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  63

Leu Ala Ser Asn Leu Glu Ser 
1               5           


<210>  64
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  64

Gln Gln Asn Asn Glu Asp Pro Tyr Thr 
1               5                   


<210>  65
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleic acid

<400>  65
gaagtgcagc tggtggaatc cggcggaggc ctggtgcagc ctggcggatc tctgagactg       60

tcttgtgccg cctccggctt caccttctcc aactactacc tgaactgggt gcgacaggcc      120

cctggcaagg gactggaatg ggtggccgac atccggctga agtccaacaa ctacgagaag      180

cactacgccg agtccgtgaa gggccggttc accatctctc gggacgactc caagaactcc      240

ctgtacctgc agatgaacag cctgaaaacc gaggacaccg ccgtgtacta ctgcatcaga      300

gagggcgact acttcgacta ctggggccag ggcaccaccg tgaccgtgag ctca            354


<210>  66
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleic acid

<400>  66
gacatcgtga tgacccagac ccctctgtcc ctgtccgtga cccctggaca gcctgcctcc       60

atctcctgca aggcctccga gtccgtggac tctttcggcg ccaccttcat gcactggtat      120

ctgcagaagc ccggccagcc ccctcagctg ctgatctacc tggcctccaa cctggaatcc      180

ggcgtgcccg acagattctc cggctctggc tctggcaccg acttcaccct gaagatctcc      240

cgggtggaag ccgaggacgt gggcgtgtac tactgccagc agaacaacga ggacccctac      300

accttcggcc agggcaccaa gctggaaatc aag                                   333


<210>  67
<211>  443
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  67

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Tyr Leu Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asp Ile Arg Leu Lys Ser Asn Asn Tyr Glu Lys His Tyr Ala Glu 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Ser 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ile Arg Glu Gly Asp Tyr Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Thr Val Glu Arg Lys Cys Cys Val Glu Cys 
    210                 215                 220                 


Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe 
225                 230                 235                 240 


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
                245                 250                 255     


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe 
            260                 265                 270         


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
        275                 280                 285             


Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr 
    290                 295                 300                 


Val Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
305                 310                 315                 320 


Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr 
                325                 330                 335     


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
            340                 345                 350         


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
        355                 360                 365             


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
    370                 375                 380                 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser 
385                 390                 395                 400 


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
                405                 410                 415     


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
            420                 425                 430         


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440             


<210>  68
<211>  218
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  68

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ala Ser Glu Ser Val Asp Ser Phe 
            20                  25                  30          


Gly Ala Thr Phe Met His Trp Tyr Leu Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Gln Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser 
65                  70                  75                  80  


Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Gln Gln Asn Asn 
                85                  90                  95      


Glu Asp Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 110         


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120                 125             


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    130                 135                 140                 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
145                 150                 155                 160 


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            180                 185                 190         


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
        195                 200                 205             


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215             


<210>  69
<211>  1329
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleic acid

<400>  69
gaagtgcagc tggtggaatc cggcggaggc ctggtgcagc ctggcggatc tctgagactg       60

tcttgtgccg cctccggctt caccttctcc aactactacc tgaactgggt gcgacaggcc      120

cctggcaagg gactggaatg ggtggccgac atccggctga agtccaacaa ctacgagaag      180

cactacgccg agtccgtgaa gggccggttc accatctctc gggacgactc caagaactcc      240

ctgtacctgc agatgaacag cctgaaaacc gaggacaccg ccgtgtacta ctgcatcaga      300

gagggcgact acttcgacta ctggggccag ggcaccaccg tgaccgtgag ctcagcttcc      360

accaagggcc cctccgtgtt ccctctggcc ccttgctccc ggtccacctc tgagtctacc      420

gccgctctgg gctgcctggt gaaagactac ttccccgagc ccgtgaccgt gtcctggaac      480

tctggcgccc tgacctccgg cgtgcacacc tttccagccg tgctgcagtc ctccggcctg      540

tactccctgt cctccgtggt gacagtgccc tcctccaact tcggcaccca gacctacacc      600

tgtaacgtgg accacaagcc ctccaacacc aaggtggaca agaccgtgga acggaagtgc      660

tgcgtggaat gcccaccctg tcctgctcca cctgtggctg gccccagcgt gttcctgttc      720

cccccaaagc ccaaggacac cctgatgatc tcccggaccc ccgaagtgac ctgcgtggtg      780

gtggacgtgt cccacgagga ccccgaggtg cagttcaatt ggtacgtgga cggcgtggaa      840

gtgcacaacg ccaagaccaa gcccagagag gaacagttca actccacctt ccgggtggtg      900

tccgtgctga ccgtggtgca tcaggactgg ctgaacggca aagagtacaa gtgcaaggtc      960

tccaacaagg gcctgcctgc ccccatcgaa aagaccatca gcaagaccaa gggccagccc     1020

cgcgagcccc aggtgtacac actgcccccc agccgggaag agatgaccaa gaaccaggtg     1080

tccctgacct gtctggtgaa aggcttctac ccctccgaca ttgccgtgga atgggagtcc     1140

aacggacagc ctgagaacaa ctacaagacc acccccccca tgctggactc cgacggctca     1200

ttcttcctgt actccaagct gacagtggac aagtcccggt ggcagcaggg caacgtgttc     1260

tcctgctccg tgatgcacga ggccctgcac aaccactaca cccagaagtc cctgtccctg     1320

agccccggc                                                             1329


<210>  70
<211>  654
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleic acid

<400>  70
gacatcgtga tgacccagac ccctctgtcc ctgtccgtga cccctggaca gcctgcctcc       60

atctcctgca aggcctccga gtccgtggac tctttcggcg ccaccttcat gcactggtat      120

ctgcagaagc ccggccagcc ccctcagctg ctgatctacc tggcctccaa cctggaatcc      180

ggcgtgcccg acagattctc cggctctggc tctggcaccg acttcaccct gaagatctcc      240

cgggtggaag ccgaggacgt gggcgtgtac tactgccagc agaacaacga ggacccctac      300

accttcggcc agggcaccaa gctggaaatc aagcggaccg tggccgctcc ctccgtgttt      360

atcttcccac cctccgacga gcagctgaag tccggcacag cttccgtcgt gtgcctgctg      420

aacaacttct acccccgcga ggccaaggtg cagtggaagg tggacaacgc cctgcagtcc      480

ggcaactccc aggaatccgt gaccgagcag gactccaagg acagcaccta ctccctgtcc      540

tccaccctga ccctgtccaa ggccgactac gagaagcaca aggtgtacgc ctgcgaagtg      600

acccaccagg gcctgtctag ccccgtgacc aagtctttca accggggcga gtgt            654


<210>  71
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  71

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Tyr Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Asp Ile Arg Leu Lys Ser Asn Asn Tyr Glu Lys His Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Arg Glu Gly Asp Tyr Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  72
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  72

Ser Tyr Tyr Met Asn 
1               5   


<210>  73
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  73

Asp Ile Arg Leu Lys Ser Asn Asn Tyr Glu Lys His Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Gly 
            


<210>  74
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  74

Ala Arg Glu Gly Asp Tyr Phe Asp Tyr 
1               5                   


<210>  75
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleic acid

<400>  75
gaagtgcagc tggtggaatc cggcggaggc ctggtgcagc ctggcggatc tctgagactg       60

tcttgtgccg cctccggctt caccttctcc agctactaca tgaactgggt gcgacaggcc      120

cctggcaagg gcctggaatg ggtgtccgac atccggctga agtccaacaa ctacgagaag      180

cactacgccg actccgtgaa gggccggttc accatcagcc gggacaacgc caagaactcc      240

ctgtacctgc agatgaacag cctgcgggcc gaggacaccg ccgtgtacta ctgtgctaga      300

gagggcgact acttcgacta ctggggccag ggcaccctcg tgaccgtgag ctca            354


<210>  76
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleic acid

<400>  76
gatatcgtgc tgacccagac ccctctgtcc ctgtctgtga cccctggcca gcctgcctcc       60

atctcctgta gagcctccga gtccgtggac tccttcggcg ccaccttcat gcactggtat      120

ctgcagaagc ccggccagcc ccctcagctg ctgatctacc tggcctccaa cctggaatcc      180

ggcgtgcccg acagattctc cggctctggc tctggcaccg acttcaccct gaagatctcc      240

cgggtggaag ccgaggacgt gggcgtgtac tactgccagc agaacaacga ggacccctac      300

accttcggcc agggcaccaa gctggaaatc aag                                   333


<210>  77
<211>  443
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  77

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Tyr Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Asp Ile Arg Leu Lys Ser Asn Asn Tyr Glu Lys His Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Arg Glu Gly Asp Tyr Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Thr Val Glu Arg Lys Cys Cys Val Glu Cys 
    210                 215                 220                 


Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe 
225                 230                 235                 240 


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
                245                 250                 255     


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe 
            260                 265                 270         


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
        275                 280                 285             


Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr 
    290                 295                 300                 


Val Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
305                 310                 315                 320 


Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr 
                325                 330                 335     


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
            340                 345                 350         


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
        355                 360                 365             


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
    370                 375                 380                 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser 
385                 390                 395                 400 


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
                405                 410                 415     


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
            420                 425                 430         


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440             


<210>  78
<211>  218
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  78

Asp Ile Val Leu Thr Gln Thr Pro Leu Ser Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Ser Phe 
            20                  25                  30          


Gly Ala Thr Phe Met His Trp Tyr Leu Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Gln Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser 
65                  70                  75                  80  


Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Gln Gln Asn Asn 
                85                  90                  95      


Glu Asp Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 110         


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120                 125             


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    130                 135                 140                 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
145                 150                 155                 160 


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            180                 185                 190         


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
        195                 200                 205             


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215             


<210>  79
<211>  1329
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleic acid

<400>  79
gaagtgcagc tggtggaatc cggcggaggc ctggtgcagc ctggcggatc tctgagactg       60

tcttgtgccg cctccggctt caccttctcc agctactaca tgaactgggt gcgacaggcc      120

cctggcaagg gcctggaatg ggtgtccgac atccggctga agtccaacaa ctacgagaag      180

cactacgccg actccgtgaa gggccggttc accatcagcc gggacaacgc caagaactcc      240

ctgtacctgc agatgaacag cctgcgggcc gaggacaccg ccgtgtacta ctgtgctaga      300

gagggcgact acttcgacta ctggggccag ggcaccctcg tgaccgtgag ctcagcttcc      360

accaagggcc cctccgtgtt ccctctggcc ccttgctccc ggtccacctc tgagtctacc      420

gccgctctgg gctgcctggt gaaagactac ttccccgagc ccgtgaccgt gtcctggaac      480

tctggcgccc tgacctccgg cgtgcacacc tttccagccg tgctgcagtc ctccggcctg      540

tactccctgt cctccgtggt gacagtgccc tcctccaact tcggcaccca gacctacacc      600

tgtaacgtgg accacaagcc ctccaacacc aaggtggaca agaccgtgga acggaagtgc      660

tgcgtggaat gcccaccctg tcctgctcca cctgtggctg gccccagcgt gttcctgttc      720

cccccaaagc ccaaggacac cctgatgatc tcccggaccc ccgaagtgac ctgcgtggtg      780

gtggacgtgt cccacgagga ccccgaggtg cagttcaatt ggtacgtgga cggcgtggaa      840

gtgcacaacg ccaagaccaa gcccagagag gaacagttca actccacctt ccgggtggtg      900

tccgtgctga ccgtggtgca tcaggactgg ctgaacggca aagagtacaa gtgcaaggtc      960

tccaacaagg gcctgcctgc ccccatcgaa aagaccatca gcaagaccaa gggccagccc     1020

cgcgagcccc aggtgtacac actgcccccc agccgggaag agatgaccaa gaaccaggtg     1080

tccctgacct gtctggtgaa aggcttctac ccctccgaca ttgccgtgga atgggagtcc     1140

aacggacagc ctgagaacaa ctacaagacc acccccccca tgctggactc cgacggctca     1200

ttcttcctgt actccaagct gacagtggac aagtcccggt ggcagcaggg caacgtgttc     1260

tcctgctccg tgatgcacga ggccctgcac aaccactaca cccagaagtc cctgtccctg     1320

agccccggc                                                             1329


<210>  80
<211>  654
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleic acid

<400>  80
gatatcgtgc tgacccagac ccctctgtcc ctgtctgtga cccctggcca gcctgcctcc       60

atctcctgta gagcctccga gtccgtggac tccttcggcg ccaccttcat gcactggtat      120

ctgcagaagc ccggccagcc ccctcagctg ctgatctacc tggcctccaa cctggaatcc      180

ggcgtgcccg acagattctc cggctctggc tctggcaccg acttcaccct gaagatctcc      240

cgggtggaag ccgaggacgt gggcgtgtac tactgccagc agaacaacga ggacccctac      300

accttcggcc agggcaccaa gctggaaatc aagcggaccg tggccgctcc ctccgtgttt      360

atcttcccac cctccgacga gcagctgaag tccggcacag cttccgtcgt gtgcctgctg      420

aacaacttct acccccgcga ggccaaggtg cagtggaagg tggacaacgc cctgcagtcc      480

ggcaactccc aggaatccgt gaccgagcag gactccaagg acagcaccta ctccctgtcc      540

tccaccctga ccctgtccaa ggccgactac gagaagcaca aggtgtacgc ctgcgaagtg      600

acccaccagg gcctgtctag ccccgtgacc aagtctttca accggggcga gtgt            654


<210>  81
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  81

Asp Ile Val Leu Thr Gln Thr Pro Leu Ser Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Ser Phe 
            20                  25                  30          


Gly Ala Thr Phe Met His Trp Tyr Leu Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Gln Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser 
65                  70                  75                  80  


Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Gln Gln Asn Asn 
                85                  90                  95      


Glu Asp Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  82
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  82

Arg Ala Ser Glu Ser Val Asp Ser Phe Gly Ala Thr Phe Met His 
1               5                   10                  15  


<210>  83
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  83

Leu Ala Ser Asn Leu Glu Ser 
1               5           


<210>  84
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  84

Gln Gln Asn Asn Glu Asp Pro Tyr Thr 
1               5                   


