                         SEQUENCE LISTING

<110>  HASTINGS, Michelle L
       ISACSON, Ole
       KORECKA, Joanna A
 
<120>  ANTISENSE COMPOUNDS TARGETING LEUCINE-RICH REPEAT KINASE 2 
       (LRRK2) FOR THE TREATMENT OF PARKINSONS DISEASE

<130>  15-1785-WO

<150>  US 62/257,109
<151>  2015-11-18

<160>  5     

<170>  PatentIn version 3.5

<210>  1
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  1
ctaccagcct accatgttac cttga                                             25


<210>  2
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  2
agacagacct gatcacctac ctggt                                             25


<210>  3
<211>  9239
<212>  DNA
<213>  Homo sapiens

<400>  3
gcgctggctg cgggcggtga gctgagctcg cccccgggga gctgtggccg gcgcccctgc       60

cggttccctg agcagcggac gttcatgctg ggagggcggc gggttggaag caggtgccac      120

catggctagt ggcagctgtc aggggtgcga agaggacgag gaaactctga agaagttgat      180

agtcaggctg aacaatgtcc aggaaggaaa acagatagaa acgctggtcc aaatcctgga      240

ggatctgctg gtgttcacgt actccgagca cgcctccaag ttatttcaag gcaaaaatat      300

ccatgtgcct ctgttgatcg tcttggactc ctatatgaga gtcgcgagtg tgcagcaggt      360

gggttggtca cttctgtgca aattaataga agtctgtcca ggtacaatgc aaagcttaat      420

gggaccccag gatgttggaa atgattggga agtccttggt gttcaccaat tgattcttaa      480

aatgctaaca gttcataatg ccagtgtaaa cttgtcagtg attggactga agaccttaga      540

tctcctccta acttcaggta aaatcacctt gctgatattg gatgaagaaa gtgatatttt      600

catgttaatt tttgatgcca tgcactcatt tccagccaat gatgaagtcc agaaacttgg      660

atgcaaagct ttacatgtgc tgtttgagag agtctcagag gagcaactga ctgaatttgt      720

tgagaacaaa gattatatga tattgttaag tgcgttaaca aattttaaag atgaagagga      780

aattgtgctt catgtgctgc attgtttaca ttccctagcg attccttgca ataatgtgga      840

agtcctcatg agtggcaatg tcaggtgtta taatattgtg gtggaagcta tgaaagcatt      900

ccctatgagt gaaagaattc aagaagtgag ttgctgtttg ctccataggc ttacattagg      960

taattttttc aatatcctgg tattaaacga agtccatgag tttgtggtga aagctgtgca     1020

gcagtaccca gagaatgcag cattgcagat ctcagcgctc agctgtttgg ccctcctcac     1080

tgagactatt ttcttaaatc aagatttaga ggaaaagaat gagaatcaag agaatgatga     1140

tgagggggaa gaagataaat tgttttggct ggaagcctgt tacaaagcat taacgtggca     1200

tagaaagaac aagcacgtgc aggaggccgc atgctgggca ctaaataatc tccttatgta     1260

ccaaaacagt ttacatgaga agattggaga tgaagatggc catttcccag ctcataggga     1320

agtgatgctc tccatgctga tgcattcttc atcaaaggaa gttttccagg catctgcgaa     1380

tgcattgtca actctcttag aacaaaatgt taatttcaga aaaatactgt tatcaaaagg     1440

aatacacctg aatgttttgg agttaatgca gaagcatata cattctcctg aagtggctga     1500

aagtggctgt aaaatgctaa atcatctttt tgaaggaagc aacacttccc tggatataat     1560

ggcagcagtg gtccccaaaa tactaacagt tatgaaacgt catgagacat cattaccagt     1620

gcagctggag gcgcttcgag ctattttaca ttttatagtg cctggcatgc cagaagaatc     1680

cagggaggat acagaatttc atcataagct aaatatggtt aaaaaacagt gtttcaagaa     1740

tgatattcac aaactggtcc tagcagcttt gaacaggttc attggaaatc ctgggattca     1800

gaaatgtgga ttaaaagtaa tttcttctat tgtacatttt cctgatgcat tagagatgtt     1860

atccctggaa ggtgctatgg attcagtgct tcacacactg cagatgtatc cagatgacca     1920

agaaattcag tgtctgggtt taagtcttat aggatacttg attacaaaga agaatgtgtt     1980

cataggaact ggacatctgc tggcaaaaat tctggtttcc agcttatacc gatttaagga     2040

tgttgctgaa atacagacta aaggatttca gacaatctta gcaatcctca aattgtcagc     2100

atctttttct aagctgctgg tgcatcattc atttgactta gtaatattcc atcaaatgtc     2160

ttccaatatc atggaacaaa aggatcaaca gtttctaaac ctctgttgca agtgttttgc     2220

aaaagtagct atggatgatt acttaaaaaa tgtgatgcta gagagagcgt gtgatcagaa     2280

taacagcatc atggttgaat gcttgcttct attgggagca gatgccaatc aagcaaagga     2340

gggatcttct ttaatttgtc aggtatgtga gaaagagagc agtcccaaat tggtggaact     2400

cttactgaat agtggatctc gtgaacaaga tgtacgaaaa gcgttgacga taagcattgg     2460

gaaaggtgac agccagatca tcagcttgct cttaaggagg ctggccctgg atgtggccaa     2520

caatagcatt tgccttggag gattttgtat aggaaaagtt gaaccttctt ggcttggtcc     2580

tttatttcca gataagactt ctaatttaag gaaacaaaca aatatagcat ctacactagc     2640

aagaatggtg atcagatatc agatgaaaag tgctgtggaa gaaggaacag cctcaggcag     2700

cgatggaaat ttttctgaag atgtgctgtc taaatttgat gaatggacct ttattcctga     2760

ctcttctatg gacagtgtgt ttgctcaaag tgatgacctg gatagtgaag gaagtgaagg     2820

ctcatttctt gtgaaaaaga aatctaattc aattagtgta ggagaatttt accgagatgc     2880

cgtattacag cgttgctcac caaatttgca aagacattcc aattccttgg ggcccatttt     2940

tgatcatgaa gatttactga agcgaaaaag aaaaatatta tcttcagatg attcactcag     3000

gtcatcaaaa cttcaatccc atatgaggca ttcagacagc atttcttctc tggcttctga     3060

gagagaatat attacatcac tagacctttc agcaaatgaa ctaagagata ttgatgccct     3120

aagccagaaa tgctgtataa gtgttcattt ggagcatctt gaaaagctgg agcttcacca     3180

gaatgcactc acgagctttc cacaacagct atgtgaaact ctgaagagtt tgacacattt     3240

ggacttgcac agtaataaat ttacatcatt tccttcttat ttgttgaaaa tgagttgtat     3300

tgctaatctt gatgtctctc gaaatgacat tggaccctca gtggttttag atcctacagt     3360

gaaatgtcca actctgaaac agtttaacct gtcatataac cagctgtctt ttgtacctga     3420

gaacctcact gatgtggtag agaaactgga gcagctcatt ttagaaggaa ataaaatatc     3480

agggatatgc tcccccttga gactgaagga actgaagatt ttaaacctta gtaagaacca     3540

catttcatcc ctatcagaga actttcttga ggcttgtcct aaagtggaga gtttcagtgc     3600

cagaatgaat tttcttgctg ctatgccttt cttgcctcct tctatgacaa tcctaaaatt     3660

atctcagaac aaattttcct gtattccaga agcaatttta aatcttccac acttgcggtc     3720

tttagatatg agcagcaatg atattcagta cctaccaggt cccgcacact ggaaatcttt     3780

gaacttaagg gaactcttat ttagccataa tcagatcagc atcttggact tgagtgaaaa     3840

agcatattta tggtctagag tagagaaact gcatctttct cacaataaac tgaaagagat     3900

tcctcctgag attggctgtc ttgaaaatct gacatctctg gatgtcagtt acaacttgga     3960

actaagatcc tttcccaatg aaatggggaa attaagcaaa atatgggatc ttcctttgga     4020

tgaactgcat cttaactttg attttaaaca tataggatgt aaagccaaag acatcataag     4080

gtttcttcaa cagcgattaa aaaaggctgt gccttataac cgaatgaaac ttatgattgt     4140

gggaaatact gggagtggta aaaccacctt attgcagcaa ttaatgaaaa ccaagaaatc     4200

agatcttgga atgcaaagtg ccacagttgg catagatgtg aaagactggc ctatccaaat     4260

aagagacaaa agaaagagag atctcgtcct aaatgtgtgg gattttgcag gtcgtgagga     4320

attctatagt actcatcccc attttatgac gcagcgagca ttgtaccttg ctgtctatga     4380

cctcagcaag ggacaggctg aagttgatgc catgaagcct tggctcttca atataaaggc     4440

tcgcgcttct tcttcccctg tgattctcgt tggcacacat ttggatgttt ctgatgagaa     4500

gcaacgcaaa gcctgcatga gtaaaatcac caaggaactc ctgaataagc gagggttccc     4560

tgccatacga gattaccact ttgtgaatgc caccgaggaa tctgatgctt tggcaaaact     4620

tcggaaaacc atcataaacg agagccttaa tttcaagatc cgagatcagc ttgttgttgg     4680

acagctgatt ccagactgct atgtagaact tgaaaaaatc attttatcgg agcgtaaaaa     4740

tgtgccaatt gaatttcccg taattgaccg gaaacgatta ttacaactag tgagagaaaa     4800

tcagctgcag ttagatgaaa atgagcttcc tcacgcagtt cactttctaa atgaatcagg     4860

agtccttctt cattttcaag acccagcact gcagttaagt gacttgtact ttgtggaacc     4920

caagtggctt tgtaaaatca tggcacagat tttgacagtg aaagtggaag gttgtccaaa     4980

acaccctaag ggcattattt cgcgtagaga tgtggaaaaa tttctttcaa aaaaaaggaa     5040

atttccaaag aactacatgt cacagtattt taagctccta gaaaaattcc agattgcttt     5100

gccaatagga gaagaatatt tgctggttcc aagcagtttg tctgaccaca ggcctgtgat     5160

agagcttccc cattgtgaga actctgaaat tatcatccga ctatatgaaa tgccttattt     5220

tccaatggga ttttggtcaa gattaatcaa tcgattactt gagatttcac cttacatgct     5280

ttcagggaga gaacgagcac ttcgcccaaa cagaatgtat tggcgacaag gcatttactt     5340

aaattggtct cctgaagctt attgtctggt aggatctgaa gtcttagaca atcatccaga     5400

gagtttctta aaaattacag ttccttcttg tagaaaaggc tgtattcttt tgggccaagt     5460

tgtggaccac attgattctc tcatggaaga atggtttcct gggttgctgg agattgatat     5520

ttgtggtgaa ggagaaactc tgttgaagaa atgggcatta tatagtttta atgatggtga     5580

agaacatcaa aaaatcttac ttgatgactt gatgaagaaa gcagaggaag gagatctctt     5640

agtaaatcca gatcaaccaa ggctcaccat tccaatatct cagattgccc ctgacttgat     5700

tttggctgac ctgcctagaa atattatgtt gaataatgat gagttggaat ttgaacaagc     5760

tccagagttt ctcctaggtg atggcagttt tggatcagtt taccgagcag cctatgaagg     5820

agaagaagtg gctgtgaaga tttttaataa acatacatca ctcaggctgt taagacaaga     5880

gcttgtggtg ctttgccacc tccaccaccc cagtttgata tctttgctgg cagctgggat     5940

tcgtccccgg atgttggtga tggagttagc ctccaagggt tccttggatc gcctgcttca     6000

gcaggacaaa gccagcctca ctagaaccct acagcacagg attgcactcc acgtagctga     6060

tggtttgaga tacctccact cagccatgat tatataccga gacctgaaac cccacaatgt     6120

gctgcttttc acactgtatc ccaatgctgc catcattgca aagattgctg actacggcat     6180

tgctcagtac tgctgtagaa tggggataaa aacatcagag ggcacaccag ggtttcgtgc     6240

acctgaagtt gccagaggaa atgtcattta taaccaacag gctgatgttt attcatttgg     6300

tttactactc tatgacattt tgacaactgg aggtagaata gtagagggtt tgaagtttcc     6360

aaatgagttt gatgaattag aaatacaagg aaaattacct gatccagtta aagaatatgg     6420

ttgtgcccca tggcctatgg ttgagaaatt aattaaacag tgtttgaaag aaaatcctca     6480

agaaaggcct acttctgccc aggtctttga cattttgaat tcagctgaat tagtctgtct     6540

gacgagacgc attttattac ctaaaaacgt aattgttgaa tgcatggttg ctacacatca     6600

caacagcagg aatgcaagca tttggctggg ctgtgggcac accgacagag gacagctctc     6660

atttcttgac ttaaatactg aaggatacac ttctgaggaa gttgctgata gtagaatatt     6720

gtgcttagcc ttggtgcatc ttcctgttga aaaggaaagc tggattgtgt ctgggacaca     6780

gtctggtact ctcctggtca tcaataccga agatgggaaa aagagacata ccctagaaaa     6840

gatgactgat tctgtcactt gtttgtattg caattccttt tccaagcaaa gcaaacaaaa     6900

aaattttctt ttggttggaa ccgctgatgg caagttagca atttttgaag ataagactgt     6960

taagcttaaa ggagctgctc ctttgaagat actaaatata ggaaatgtca gtactccatt     7020

gatgtgtttg agtgaatcca caaattcaac ggaaagaaat gtaatgtggg gaggatgtgg     7080

cacaaagatt ttctcctttt ctaatgattt caccattcag aaactcattg agacaagaac     7140

aagccaactg ttttcttatg cagctttcag tgattccaac atcataacag tggtggtaga     7200

cactgctctc tatattgcta agcaaaatag ccctgttgtg gaagtgtggg ataagaaaac     7260

tgaaaaactc tgtggactaa tagactgcgt gcacttttta agggaggtaa tggtaaaaga     7320

aaacaaggaa tcaaaacaca aaatgtctta ttctgggaga gtgaaaaccc tctgccttca     7380

gaagaacact gctctttgga taggaactgg aggaggccat attttactcc tggatctttc     7440

aactcgtcga cttatacgtg taatttacaa cttttgtaat tcggtcagag tcatgatgac     7500

agcacagcta ggaagcctta aaaatgtcat gctggtattg ggctacaacc ggaaaaatac     7560

tgaaggtaca caaaagcaga aagagataca atcttgcttg accgtttggg acatcaatct     7620

tccacatgaa gtgcaaaatt tagaaaaaca cattgaagtg agaaaagaat tagctgaaaa     7680

aatgagacga acatctgttg agtaagagag aaataggaat tgtctttgga taggaaaatt     7740

attctctcct cttgtaaata tttattttaa aaatgttcac atggaaaggg tactcacatt     7800

ttttgaaata gctcgtgtgt atgaaggaat gttattattt ttaatttaaa tatatgtaaa     7860

aatacttacc agtaaatgtg tattttaaag aactatttaa aacacaatgt tatatttctt     7920

ataaatacca gttactttcg ttcattaatt aatgaaaata aatctgtgaa gtacctaatt     7980

taagtactca tactaaaatt tataaggccg ataatttttt gttttcttgt ctgtaatgga     8040

ggtaaacttt attttaaatt ctgtgcttaa gacaggacta ttgcttgtcg atttttctag     8100

aaatctgcac ggtataatga aaatattaag acagtttccc atgtaatgta ttccttctta     8160

gattgcatcg aaatgcacta tcatatatgc ttgtaaatat tcaaatgaat ttgcactaat     8220

aaagtccttt gttggtatgt gaattctctt tgttgctgtt gcaaacagtg catcttacac     8280

aacttcactc aattcaaaag aaaactccat taaaagtact aatgaaaaaa catgacatac     8340

tgtcaaagtc ctcatatcta ggaaagacac agaaactctc tttgtcacag aaactctctg     8400

tgtctttcct agacataata gagttgtttt tcaactctat gtttgaatgt ggataccctg     8460

aattttgtat aattagtgta aatacagtgt tcagtccttc aagtgatatt tttatttttt     8520

tattcatacc actagctact tgttttctaa tctgcttcat tctaatgctt atattcatct     8580

tttccctaaa tttgtgatgc tgcagatcct acatcattca gatagaaacc tttttttttt     8640

tcagaattat agaattccac agctcctacc aagaccatga ggataaatat ctaacacttt     8700

tcagttgctg aaggagaaag gagctttagt tatgatggat aaaaatatct gccaccctag     8760

gcttccaaat tatacttaaa ttgtttacat agcttaccac aataggagta tcagggccaa     8820

atacctatgt aataatttga ggtcatttct gctttaggaa aagtactttc ggtaaattct     8880

ttggccctga ccagtattca ttatttcaga taattccctg tgataggaca actagtacat     8940

ttaatattct cagaacttat ggcattttac tatgtgaaaa ctttaaattt atttatatta     9000

agggtaatca aattcttaaa gatgaaagat tttctgtatt ttaaaggaag ctatgcttta     9060

acttgttatg taattaacaa aaaaatcata tataatagag ctctttgttc cagtgttatc     9120

tctttcattg ttactttgta tttgcaattt tttttaccaa agacaaatta aaaaaatgaa     9180

taccatattt aaatggaata ataaaggttt tttaaaaact ttaaaaaaaa aaaaaaaaa      9239


<210>  4
<211>  2527
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Ala Ser Gly Ser Cys Gln Gly Cys Glu Glu Asp Glu Glu Thr Leu 
1               5                   10                  15      


Lys Lys Leu Ile Val Arg Leu Asn Asn Val Gln Glu Gly Lys Gln Ile 
            20                  25                  30          


Glu Thr Leu Val Gln Ile Leu Glu Asp Leu Leu Val Phe Thr Tyr Ser 
        35                  40                  45              


Glu His Ala Ser Lys Leu Phe Gln Gly Lys Asn Ile His Val Pro Leu 
    50                  55                  60                  


Leu Ile Val Leu Asp Ser Tyr Met Arg Val Ala Ser Val Gln Gln Val 
65                  70                  75                  80  


Gly Trp Ser Leu Leu Cys Lys Leu Ile Glu Val Cys Pro Gly Thr Met 
                85                  90                  95      


Gln Ser Leu Met Gly Pro Gln Asp Val Gly Asn Asp Trp Glu Val Leu 
            100                 105                 110         


Gly Val His Gln Leu Ile Leu Lys Met Leu Thr Val His Asn Ala Ser 
        115                 120                 125             


Val Asn Leu Ser Val Ile Gly Leu Lys Thr Leu Asp Leu Leu Leu Thr 
    130                 135                 140                 


Ser Gly Lys Ile Thr Leu Leu Ile Leu Asp Glu Glu Ser Asp Ile Phe 
145                 150                 155                 160 


Met Leu Ile Phe Asp Ala Met His Ser Phe Pro Ala Asn Asp Glu Val 
                165                 170                 175     


Gln Lys Leu Gly Cys Lys Ala Leu His Val Leu Phe Glu Arg Val Ser 
            180                 185                 190         


Glu Glu Gln Leu Thr Glu Phe Val Glu Asn Lys Asp Tyr Met Ile Leu 
        195                 200                 205             


Leu Ser Ala Leu Thr Asn Phe Lys Asp Glu Glu Glu Ile Val Leu His 
    210                 215                 220                 


Val Leu His Cys Leu His Ser Leu Ala Ile Pro Cys Asn Asn Val Glu 
225                 230                 235                 240 


Val Leu Met Ser Gly Asn Val Arg Cys Tyr Asn Ile Val Val Glu Ala 
                245                 250                 255     


Met Lys Ala Phe Pro Met Ser Glu Arg Ile Gln Glu Val Ser Cys Cys 
            260                 265                 270         


Leu Leu His Arg Leu Thr Leu Gly Asn Phe Phe Asn Ile Leu Val Leu 
        275                 280                 285             


Asn Glu Val His Glu Phe Val Val Lys Ala Val Gln Gln Tyr Pro Glu 
    290                 295                 300                 


Asn Ala Ala Leu Gln Ile Ser Ala Leu Ser Cys Leu Ala Leu Leu Thr 
305                 310                 315                 320 


Glu Thr Ile Phe Leu Asn Gln Asp Leu Glu Glu Lys Asn Glu Asn Gln 
                325                 330                 335     


Glu Asn Asp Asp Glu Gly Glu Glu Asp Lys Leu Phe Trp Leu Glu Ala 
            340                 345                 350         


Cys Tyr Lys Ala Leu Thr Trp His Arg Lys Asn Lys His Val Gln Glu 
        355                 360                 365             


Ala Ala Cys Trp Ala Leu Asn Asn Leu Leu Met Tyr Gln Asn Ser Leu 
    370                 375                 380                 


His Glu Lys Ile Gly Asp Glu Asp Gly His Phe Pro Ala His Arg Glu 
385                 390                 395                 400 


Val Met Leu Ser Met Leu Met His Ser Ser Ser Lys Glu Val Phe Gln 
                405                 410                 415     


Ala Ser Ala Asn Ala Leu Ser Thr Leu Leu Glu Gln Asn Val Asn Phe 
            420                 425                 430         


Arg Lys Ile Leu Leu Ser Lys Gly Ile His Leu Asn Val Leu Glu Leu 
        435                 440                 445             


Met Gln Lys His Ile His Ser Pro Glu Val Ala Glu Ser Gly Cys Lys 
    450                 455                 460                 


Met Leu Asn His Leu Phe Glu Gly Ser Asn Thr Ser Leu Asp Ile Met 
465                 470                 475                 480 


Ala Ala Val Val Pro Lys Ile Leu Thr Val Met Lys Arg His Glu Thr 
                485                 490                 495     


Ser Leu Pro Val Gln Leu Glu Ala Leu Arg Ala Ile Leu His Phe Ile 
            500                 505                 510         


Val Pro Gly Met Pro Glu Glu Ser Arg Glu Asp Thr Glu Phe His His 
        515                 520                 525             


Lys Leu Asn Met Val Lys Lys Gln Cys Phe Lys Asn Asp Ile His Lys 
    530                 535                 540                 


Leu Val Leu Ala Ala Leu Asn Arg Phe Ile Gly Asn Pro Gly Ile Gln 
545                 550                 555                 560 


Lys Cys Gly Leu Lys Val Ile Ser Ser Ile Val His Phe Pro Asp Ala 
                565                 570                 575     


Leu Glu Met Leu Ser Leu Glu Gly Ala Met Asp Ser Val Leu His Thr 
            580                 585                 590         


Leu Gln Met Tyr Pro Asp Asp Gln Glu Ile Gln Cys Leu Gly Leu Ser 
        595                 600                 605             


Leu Ile Gly Tyr Leu Ile Thr Lys Lys Asn Val Phe Ile Gly Thr Gly 
    610                 615                 620                 


His Leu Leu Ala Lys Ile Leu Val Ser Ser Leu Tyr Arg Phe Lys Asp 
625                 630                 635                 640 


Val Ala Glu Ile Gln Thr Lys Gly Phe Gln Thr Ile Leu Ala Ile Leu 
                645                 650                 655     


Lys Leu Ser Ala Ser Phe Ser Lys Leu Leu Val His His Ser Phe Asp 
            660                 665                 670         


Leu Val Ile Phe His Gln Met Ser Ser Asn Ile Met Glu Gln Lys Asp 
        675                 680                 685             


Gln Gln Phe Leu Asn Leu Cys Cys Lys Cys Phe Ala Lys Val Ala Met 
    690                 695                 700                 


Asp Asp Tyr Leu Lys Asn Val Met Leu Glu Arg Ala Cys Asp Gln Asn 
705                 710                 715                 720 


Asn Ser Ile Met Val Glu Cys Leu Leu Leu Leu Gly Ala Asp Ala Asn 
                725                 730                 735     


Gln Ala Lys Glu Gly Ser Ser Leu Ile Cys Gln Val Cys Glu Lys Glu 
            740                 745                 750         


Ser Ser Pro Lys Leu Val Glu Leu Leu Leu Asn Ser Gly Ser Arg Glu 
        755                 760                 765             


Gln Asp Val Arg Lys Ala Leu Thr Ile Ser Ile Gly Lys Gly Asp Ser 
    770                 775                 780                 


Gln Ile Ile Ser Leu Leu Leu Arg Arg Leu Ala Leu Asp Val Ala Asn 
785                 790                 795                 800 


Asn Ser Ile Cys Leu Gly Gly Phe Cys Ile Gly Lys Val Glu Pro Ser 
                805                 810                 815     


Trp Leu Gly Pro Leu Phe Pro Asp Lys Thr Ser Asn Leu Arg Lys Gln 
            820                 825                 830         


Thr Asn Ile Ala Ser Thr Leu Ala Arg Met Val Ile Arg Tyr Gln Met 
        835                 840                 845             


Lys Ser Ala Val Glu Glu Gly Thr Ala Ser Gly Ser Asp Gly Asn Phe 
    850                 855                 860                 


Ser Glu Asp Val Leu Ser Lys Phe Asp Glu Trp Thr Phe Ile Pro Asp 
865                 870                 875                 880 


Ser Ser Met Asp Ser Val Phe Ala Gln Ser Asp Asp Leu Asp Ser Glu 
                885                 890                 895     


Gly Ser Glu Gly Ser Phe Leu Val Lys Lys Lys Ser Asn Ser Ile Ser 
            900                 905                 910         


Val Gly Glu Phe Tyr Arg Asp Ala Val Leu Gln Arg Cys Ser Pro Asn 
        915                 920                 925             


Leu Gln Arg His Ser Asn Ser Leu Gly Pro Ile Phe Asp His Glu Asp 
    930                 935                 940                 


Leu Leu Lys Arg Lys Arg Lys Ile Leu Ser Ser Asp Asp Ser Leu Arg 
945                 950                 955                 960 


Ser Ser Lys Leu Gln Ser His Met Arg His Ser Asp Ser Ile Ser Ser 
                965                 970                 975     


Leu Ala Ser Glu Arg Glu Tyr Ile Thr Ser Leu Asp Leu Ser Ala Asn 
            980                 985                 990         


Glu Leu Arg Asp Ile Asp Ala Leu  Ser Gln Lys Cys Cys  Ile Ser Val 
        995                 1000                 1005             


His Leu  Glu His Leu Glu Lys  Leu Glu Leu His Gln  Asn Ala Leu 
    1010                 1015                 1020             


Thr Ser  Phe Pro Gln Gln Leu  Cys Glu Thr Leu Lys  Ser Leu Thr 
    1025                 1030                 1035             


His Leu  Asp Leu His Ser Asn  Lys Phe Thr Ser Phe  Pro Ser Tyr 
    1040                 1045                 1050             


Leu Leu  Lys Met Ser Cys Ile  Ala Asn Leu Asp Val  Ser Arg Asn 
    1055                 1060                 1065             


Asp Ile  Gly Pro Ser Val Val  Leu Asp Pro Thr Val  Lys Cys Pro 
    1070                 1075                 1080             


Thr Leu  Lys Gln Phe Asn Leu  Ser Tyr Asn Gln Leu  Ser Phe Val 
    1085                 1090                 1095             


Pro Glu  Asn Leu Thr Asp Val  Val Glu Lys Leu Glu  Gln Leu Ile 
    1100                 1105                 1110             


Leu Glu  Gly Asn Lys Ile Ser  Gly Ile Cys Ser Pro  Leu Arg Leu 
    1115                 1120                 1125             


Lys Glu  Leu Lys Ile Leu Asn  Leu Ser Lys Asn His  Ile Ser Ser 
    1130                 1135                 1140             


Leu Ser  Glu Asn Phe Leu Glu  Ala Cys Pro Lys Val  Glu Ser Phe 
    1145                 1150                 1155             


Ser Ala  Arg Met Asn Phe Leu  Ala Ala Met Pro Phe  Leu Pro Pro 
    1160                 1165                 1170             


Ser Met  Thr Ile Leu Lys Leu  Ser Gln Asn Lys Phe  Ser Cys Ile 
    1175                 1180                 1185             


Pro Glu  Ala Ile Leu Asn Leu  Pro His Leu Arg Ser  Leu Asp Met 
    1190                 1195                 1200             


Ser Ser  Asn Asp Ile Gln Tyr  Leu Pro Gly Pro Ala  His Trp Lys 
    1205                 1210                 1215             


Ser Leu  Asn Leu Arg Glu Leu  Leu Phe Ser His Asn  Gln Ile Ser 
    1220                 1225                 1230             


Ile Leu  Asp Leu Ser Glu Lys  Ala Tyr Leu Trp Ser  Arg Val Glu 
    1235                 1240                 1245             


Lys Leu  His Leu Ser His Asn  Lys Leu Lys Glu Ile  Pro Pro Glu 
    1250                 1255                 1260             


Ile Gly  Cys Leu Glu Asn Leu  Thr Ser Leu Asp Val  Ser Tyr Asn 
    1265                 1270                 1275             


Leu Glu  Leu Arg Ser Phe Pro  Asn Glu Met Gly Lys  Leu Ser Lys 
    1280                 1285                 1290             


Ile Trp  Asp Leu Pro Leu Asp  Glu Leu His Leu Asn  Phe Asp Phe 
    1295                 1300                 1305             


Lys His  Ile Gly Cys Lys Ala  Lys Asp Ile Ile Arg  Phe Leu Gln 
    1310                 1315                 1320             


Gln Arg  Leu Lys Lys Ala Val  Pro Tyr Asn Arg Met  Lys Leu Met 
    1325                 1330                 1335             


Ile Val  Gly Asn Thr Gly Ser  Gly Lys Thr Thr Leu  Leu Gln Gln 
    1340                 1345                 1350             


Leu Met  Lys Thr Lys Lys Ser  Asp Leu Gly Met Gln  Ser Ala Thr 
    1355                 1360                 1365             


Val Gly  Ile Asp Val Lys Asp  Trp Pro Ile Gln Ile  Arg Asp Lys 
    1370                 1375                 1380             


Arg Lys  Arg Asp Leu Val Leu  Asn Val Trp Asp Phe  Ala Gly Arg 
    1385                 1390                 1395             


Glu Glu  Phe Tyr Ser Thr His  Pro His Phe Met Thr  Gln Arg Ala 
    1400                 1405                 1410             


Leu Tyr  Leu Ala Val Tyr Asp  Leu Ser Lys Gly Gln  Ala Glu Val 
    1415                 1420                 1425             


Asp Ala  Met Lys Pro Trp Leu  Phe Asn Ile Lys Ala  Arg Ala Ser 
    1430                 1435                 1440             


Ser Ser  Pro Val Ile Leu Val  Gly Thr His Leu Asp  Val Ser Asp 
    1445                 1450                 1455             


Glu Lys  Gln Arg Lys Ala Cys  Met Ser Lys Ile Thr  Lys Glu Leu 
    1460                 1465                 1470             


Leu Asn  Lys Arg Gly Phe Pro  Ala Ile Arg Asp Tyr  His Phe Val 
    1475                 1480                 1485             


Asn Ala  Thr Glu Glu Ser Asp  Ala Leu Ala Lys Leu  Arg Lys Thr 
    1490                 1495                 1500             


Ile Ile  Asn Glu Ser Leu Asn  Phe Lys Ile Arg Asp  Gln Leu Val 
    1505                 1510                 1515             


Val Gly  Gln Leu Ile Pro Asp  Cys Tyr Val Glu Leu  Glu Lys Ile 
    1520                 1525                 1530             


Ile Leu  Ser Glu Arg Lys Asn  Val Pro Ile Glu Phe  Pro Val Ile 
    1535                 1540                 1545             


Asp Arg  Lys Arg Leu Leu Gln  Leu Val Arg Glu Asn  Gln Leu Gln 
    1550                 1555                 1560             


Leu Asp  Glu Asn Glu Leu Pro  His Ala Val His Phe  Leu Asn Glu 
    1565                 1570                 1575             


Ser Gly  Val Leu Leu His Phe  Gln Asp Pro Ala Leu  Gln Leu Ser 
    1580                 1585                 1590             


Asp Leu  Tyr Phe Val Glu Pro  Lys Trp Leu Cys Lys  Ile Met Ala 
    1595                 1600                 1605             


Gln Ile  Leu Thr Val Lys Val  Glu Gly Cys Pro Lys  His Pro Lys 
    1610                 1615                 1620             


Gly Ile  Ile Ser Arg Arg Asp  Val Glu Lys Phe Leu  Ser Lys Lys 
    1625                 1630                 1635             


Arg Lys  Phe Pro Lys Asn Tyr  Met Ser Gln Tyr Phe  Lys Leu Leu 
    1640                 1645                 1650             


Glu Lys  Phe Gln Ile Ala Leu  Pro Ile Gly Glu Glu  Tyr Leu Leu 
    1655                 1660                 1665             


Val Pro  Ser Ser Leu Ser Asp  His Arg Pro Val Ile  Glu Leu Pro 
    1670                 1675                 1680             


His Cys  Glu Asn Ser Glu Ile  Ile Ile Arg Leu Tyr  Glu Met Pro 
    1685                 1690                 1695             


Tyr Phe  Pro Met Gly Phe Trp  Ser Arg Leu Ile Asn  Arg Leu Leu 
    1700                 1705                 1710             


Glu Ile  Ser Pro Tyr Met Leu  Ser Gly Arg Glu Arg  Ala Leu Arg 
    1715                 1720                 1725             


Pro Asn  Arg Met Tyr Trp Arg  Gln Gly Ile Tyr Leu  Asn Trp Ser 
    1730                 1735                 1740             


Pro Glu  Ala Tyr Cys Leu Val  Gly Ser Glu Val Leu  Asp Asn His 
    1745                 1750                 1755             


Pro Glu  Ser Phe Leu Lys Ile  Thr Val Pro Ser Cys  Arg Lys Gly 
    1760                 1765                 1770             


Cys Ile  Leu Leu Gly Gln Val  Val Asp His Ile Asp  Ser Leu Met 
    1775                 1780                 1785             


Glu Glu  Trp Phe Pro Gly Leu  Leu Glu Ile Asp Ile  Cys Gly Glu 
    1790                 1795                 1800             


Gly Glu  Thr Leu Leu Lys Lys  Trp Ala Leu Tyr Ser  Phe Asn Asp 
    1805                 1810                 1815             


Gly Glu  Glu His Gln Lys Ile  Leu Leu Asp Asp Leu  Met Lys Lys 
    1820                 1825                 1830             


Ala Glu  Glu Gly Asp Leu Leu  Val Asn Pro Asp Gln  Pro Arg Leu 
    1835                 1840                 1845             


Thr Ile  Pro Ile Ser Gln Ile  Ala Pro Asp Leu Ile  Leu Ala Asp 
    1850                 1855                 1860             


Leu Pro  Arg Asn Ile Met Leu  Asn Asn Asp Glu Leu  Glu Phe Glu 
    1865                 1870                 1875             


Gln Ala  Pro Glu Phe Leu Leu  Gly Asp Gly Ser Phe  Gly Ser Val 
    1880                 1885                 1890             


Tyr Arg  Ala Ala Tyr Glu Gly  Glu Glu Val Ala Val  Lys Ile Phe 
    1895                 1900                 1905             


Asn Lys  His Thr Ser Leu Arg  Leu Leu Arg Gln Glu  Leu Val Val 
    1910                 1915                 1920             


Leu Cys  His Leu His His Pro  Ser Leu Ile Ser Leu  Leu Ala Ala 
    1925                 1930                 1935             


Gly Ile  Arg Pro Arg Met Leu  Val Met Glu Leu Ala  Ser Lys Gly 
    1940                 1945                 1950             


Ser Leu  Asp Arg Leu Leu Gln  Gln Asp Lys Ala Ser  Leu Thr Arg 
    1955                 1960                 1965             


Thr Leu  Gln His Arg Ile Ala  Leu His Val Ala Asp  Gly Leu Arg 
    1970                 1975                 1980             


Tyr Leu  His Ser Ala Met Ile  Ile Tyr Arg Asp Leu  Lys Pro His 
    1985                 1990                 1995             


Asn Val  Leu Leu Phe Thr Leu  Tyr Pro Asn Ala Ala  Ile Ile Ala 
    2000                 2005                 2010             


Lys Ile  Ala Asp Tyr Gly Ile  Ala Gln Tyr Cys Cys  Arg Met Gly 
    2015                 2020                 2025             


Ile Lys  Thr Ser Glu Gly Thr  Pro Gly Phe Arg Ala  Pro Glu Val 
    2030                 2035                 2040             


Ala Arg  Gly Asn Val Ile Tyr  Asn Gln Gln Ala Asp  Val Tyr Ser 
    2045                 2050                 2055             


Phe Gly  Leu Leu Leu Tyr Asp  Ile Leu Thr Thr Gly  Gly Arg Ile 
    2060                 2065                 2070             


Val Glu  Gly Leu Lys Phe Pro  Asn Glu Phe Asp Glu  Leu Glu Ile 
    2075                 2080                 2085             


Gln Gly  Lys Leu Pro Asp Pro  Val Lys Glu Tyr Gly  Cys Ala Pro 
    2090                 2095                 2100             


Trp Pro  Met Val Glu Lys Leu  Ile Lys Gln Cys Leu  Lys Glu Asn 
    2105                 2110                 2115             


Pro Gln  Glu Arg Pro Thr Ser  Ala Gln Val Phe Asp  Ile Leu Asn 
    2120                 2125                 2130             


Ser Ala  Glu Leu Val Cys Leu  Thr Arg Arg Ile Leu  Leu Pro Lys 
    2135                 2140                 2145             


Asn Val  Ile Val Glu Cys Met  Val Ala Thr His His  Asn Ser Arg 
    2150                 2155                 2160             


Asn Ala  Ser Ile Trp Leu Gly  Cys Gly His Thr Asp  Arg Gly Gln 
    2165                 2170                 2175             


Leu Ser  Phe Leu Asp Leu Asn  Thr Glu Gly Tyr Thr  Ser Glu Glu 
    2180                 2185                 2190             


Val Ala  Asp Ser Arg Ile Leu  Cys Leu Ala Leu Val  His Leu Pro 
    2195                 2200                 2205             


Val Glu  Lys Glu Ser Trp Ile  Val Ser Gly Thr Gln  Ser Gly Thr 
    2210                 2215                 2220             


Leu Leu  Val Ile Asn Thr Glu  Asp Gly Lys Lys Arg  His Thr Leu 
    2225                 2230                 2235             


Glu Lys  Met Thr Asp Ser Val  Thr Cys Leu Tyr Cys  Asn Ser Phe 
    2240                 2245                 2250             


Ser Lys  Gln Ser Lys Gln Lys  Asn Phe Leu Leu Val  Gly Thr Ala 
    2255                 2260                 2265             


Asp Gly  Lys Leu Ala Ile Phe  Glu Asp Lys Thr Val  Lys Leu Lys 
    2270                 2275                 2280             


Gly Ala  Ala Pro Leu Lys Ile  Leu Asn Ile Gly Asn  Val Ser Thr 
    2285                 2290                 2295             


Pro Leu  Met Cys Leu Ser Glu  Ser Thr Asn Ser Thr  Glu Arg Asn 
    2300                 2305                 2310             


Val Met  Trp Gly Gly Cys Gly  Thr Lys Ile Phe Ser  Phe Ser Asn 
    2315                 2320                 2325             


Asp Phe  Thr Ile Gln Lys Leu  Ile Glu Thr Arg Thr  Ser Gln Leu 
    2330                 2335                 2340             


Phe Ser  Tyr Ala Ala Phe Ser  Asp Ser Asn Ile Ile  Thr Val Val 
    2345                 2350                 2355             


Val Asp  Thr Ala Leu Tyr Ile  Ala Lys Gln Asn Ser  Pro Val Val 
    2360                 2365                 2370             


Glu Val  Trp Asp Lys Lys Thr  Glu Lys Leu Cys Gly  Leu Ile Asp 
    2375                 2380                 2385             


Cys Val  His Phe Leu Arg Glu  Val Met Val Lys Glu  Asn Lys Glu 
    2390                 2395                 2400             


Ser Lys  His Lys Met Ser Tyr  Ser Gly Arg Val Lys  Thr Leu Cys 
    2405                 2410                 2415             


Leu Gln  Lys Asn Thr Ala Leu  Trp Ile Gly Thr Gly  Gly Gly His 
    2420                 2425                 2430             


Ile Leu  Leu Leu Asp Leu Ser  Thr Arg Arg Leu Ile  Arg Val Ile 
    2435                 2440                 2445             


Tyr Asn  Phe Cys Asn Ser Val  Arg Val Met Met Thr  Ala Gln Leu 
    2450                 2455                 2460             


Gly Ser  Leu Lys Asn Val Met  Leu Val Leu Gly Tyr  Asn Arg Lys 
    2465                 2470                 2475             


Asn Thr  Glu Gly Thr Gln Lys  Gln Lys Glu Ile Gln  Ser Cys Leu 
    2480                 2485                 2490             


Thr Val  Trp Asp Ile Asn Leu  Pro His Glu Val Gln  Asn Leu Glu 
    2495                 2500                 2505             


Lys His  Ile Glu Val Arg Lys  Glu Leu Ala Glu Lys  Met Arg Arg 
    2510                 2515                 2520             


Thr Ser  Val Glu 
    2525         


<210>  5
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  5
cctcttacct cagttacaat ttata                                             25


