                         SEQUENCE LISTING

<110>  Advaxis, Inc.
       Petit, Robert
 
<120>  Manufacturing Method Of An Immunotherapeutic Formulation 
       Comprising A Recombinant Listeria Strain

<130>  062384/480759

<150>  62/258,301
<151>  2015-11-20

<160>  38    

<170>  PatentIn version 3.5

<210>  1
<211>  529
<212>  PRT
<213>  Listeria monocytogenes

<400>  1

Met Lys Lys Ile Met Leu Val Phe Ile Thr Leu Ile Leu Val Ser Leu 
1               5                   10                  15      


Pro Ile Ala Gln Gln Thr Glu Ala Lys Asp Ala Ser Ala Phe Asn Lys 
            20                  25                  30          


Glu Asn Ser Ile Ser Ser Met Ala Pro Pro Ala Ser Pro Pro Ala Ser 
        35                  40                  45              


Pro Lys Thr Pro Ile Glu Lys Lys His Ala Asp Glu Ile Asp Lys Tyr 
    50                  55                  60                  


Ile Gln Gly Leu Asp Tyr Asn Lys Asn Asn Val Leu Val Tyr His Gly 
65                  70                  75                  80  


Asp Ala Val Thr Asn Val Pro Pro Arg Lys Gly Tyr Lys Asp Gly Asn 
                85                  90                  95      


Glu Tyr Ile Val Val Glu Lys Lys Lys Lys Ser Ile Asn Gln Asn Asn 
            100                 105                 110         


Ala Asp Ile Gln Val Val Asn Ala Ile Ser Ser Leu Thr Tyr Pro Gly 
        115                 120                 125             


Ala Leu Val Lys Ala Asn Ser Glu Leu Val Glu Asn Gln Pro Asp Val 
    130                 135                 140                 


Leu Pro Val Lys Arg Asp Ser Leu Thr Leu Ser Ile Asp Leu Pro Gly 
145                 150                 155                 160 


Met Thr Asn Gln Asp Asn Lys Ile Val Val Lys Asn Ala Thr Lys Ser 
                165                 170                 175     


Asn Val Asn Asn Ala Val Asn Thr Leu Val Glu Arg Trp Asn Glu Lys 
            180                 185                 190         


Tyr Ala Gln Ala Tyr Pro Asn Val Ser Ala Lys Ile Asp Tyr Asp Asp 
        195                 200                 205             


Glu Met Ala Tyr Ser Glu Ser Gln Leu Ile Ala Lys Phe Gly Thr Ala 
    210                 215                 220                 


Phe Lys Ala Val Asn Asn Ser Leu Asn Val Asn Phe Gly Ala Ile Ser 
225                 230                 235                 240 


Glu Gly Lys Met Gln Glu Glu Val Ile Ser Phe Lys Gln Ile Tyr Tyr 
                245                 250                 255     


Asn Val Asn Val Asn Glu Pro Thr Arg Pro Ser Arg Phe Phe Gly Lys 
            260                 265                 270         


Ala Val Thr Lys Glu Gln Leu Gln Ala Leu Gly Val Asn Ala Glu Asn 
        275                 280                 285             


Pro Pro Ala Tyr Ile Ser Ser Val Ala Tyr Gly Arg Gln Val Tyr Leu 
    290                 295                 300                 


Lys Leu Ser Thr Asn Ser His Ser Thr Lys Val Lys Ala Ala Phe Asp 
305                 310                 315                 320 


Ala Ala Val Ser Gly Lys Ser Val Ser Gly Asp Val Glu Leu Thr Asn 
                325                 330                 335     


Ile Ile Lys Asn Ser Ser Phe Lys Ala Val Ile Tyr Gly Gly Ser Ala 
            340                 345                 350         


Lys Asp Glu Val Gln Ile Ile Asp Gly Asn Leu Gly Asp Leu Arg Asp 
        355                 360                 365             


Ile Leu Lys Lys Gly Ala Thr Phe Asn Arg Glu Thr Pro Gly Val Pro 
    370                 375                 380                 


Ile Ala Tyr Thr Thr Asn Phe Leu Lys Asp Asn Glu Leu Ala Val Ile 
385                 390                 395                 400 


Lys Asn Asn Ser Glu Tyr Ile Glu Thr Thr Ser Lys Ala Tyr Thr Asp 
                405                 410                 415     


Gly Lys Ile Asn Ile Asp His Ser Gly Gly Tyr Val Ala Gln Phe Asn 
            420                 425                 430         


Ile Ser Trp Asp Glu Val Asn Tyr Asp Pro Glu Gly Asn Glu Ile Val 
        435                 440                 445             


Gln His Lys Asn Trp Ser Glu Asn Asn Lys Ser Lys Leu Ala His Phe 
    450                 455                 460                 


Thr Ser Ser Ile Tyr Leu Pro Gly Asn Ala Arg Asn Ile Asn Val Tyr 
465                 470                 475                 480 


Ala Lys Glu Cys Thr Gly Leu Ala Trp Glu Trp Trp Arg Thr Val Ile 
                485                 490                 495     


Asp Asp Arg Asn Leu Pro Leu Val Lys Asn Arg Asn Ile Ser Ile Trp 
            500                 505                 510         


Gly Thr Thr Leu Tyr Pro Lys Tyr Ser Asn Lys Val Asp Asn Pro Ile 
        515                 520                 525             


Glu 
    


<210>  2
<211>  441
<212>  PRT
<213>  Listeria monocytogenes

<400>  2

Met Lys Lys Ile Met Leu Val Phe Ile Thr Leu Ile Leu Val Ser Leu 
1               5                   10                  15      


Pro Ile Ala Gln Gln Thr Glu Ala Lys Asp Ala Ser Ala Phe Asn Lys 
            20                  25                  30          


Glu Asn Ser Ile Ser Ser Val Ala Pro Pro Ala Ser Pro Pro Ala Ser 
        35                  40                  45              


Pro Lys Thr Pro Ile Glu Lys Lys His Ala Asp Glu Ile Asp Lys Tyr 
    50                  55                  60                  


Ile Gln Gly Leu Asp Tyr Asn Lys Asn Asn Val Leu Val Tyr His Gly 
65                  70                  75                  80  


Asp Ala Val Thr Asn Val Pro Pro Arg Lys Gly Tyr Lys Asp Gly Asn 
                85                  90                  95      


Glu Tyr Ile Val Val Glu Lys Lys Lys Lys Ser Ile Asn Gln Asn Asn 
            100                 105                 110         


Ala Asp Ile Gln Val Val Asn Ala Ile Ser Ser Leu Thr Tyr Pro Gly 
        115                 120                 125             


Ala Leu Val Lys Ala Asn Ser Glu Leu Val Glu Asn Gln Pro Asp Val 
    130                 135                 140                 


Leu Pro Val Lys Arg Asp Ser Leu Thr Leu Ser Ile Asp Leu Pro Gly 
145                 150                 155                 160 


Met Thr Asn Gln Asp Asn Lys Ile Val Val Lys Asn Ala Thr Lys Ser 
                165                 170                 175     


Asn Val Asn Asn Ala Val Asn Thr Leu Val Glu Arg Trp Asn Glu Lys 
            180                 185                 190         


Tyr Ala Gln Ala Tyr Ser Asn Val Ser Ala Lys Ile Asp Tyr Asp Asp 
        195                 200                 205             


Glu Met Ala Tyr Ser Glu Ser Gln Leu Ile Ala Lys Phe Gly Thr Ala 
    210                 215                 220                 


Phe Lys Ala Val Asn Asn Ser Leu Asn Val Asn Phe Gly Ala Ile Ser 
225                 230                 235                 240 


Glu Gly Lys Met Gln Glu Glu Val Ile Ser Phe Lys Gln Ile Tyr Tyr 
                245                 250                 255     


Asn Val Asn Val Asn Glu Pro Thr Arg Pro Ser Arg Phe Phe Gly Lys 
            260                 265                 270         


Ala Val Thr Lys Glu Gln Leu Gln Ala Leu Gly Val Asn Ala Glu Asn 
        275                 280                 285             


Pro Pro Ala Tyr Ile Ser Ser Val Ala Tyr Gly Arg Gln Val Tyr Leu 
    290                 295                 300                 


Lys Leu Ser Thr Asn Ser His Ser Thr Lys Val Lys Ala Ala Phe Asp 
305                 310                 315                 320 


Ala Ala Val Ser Gly Lys Ser Val Ser Gly Asp Val Glu Leu Thr Asn 
                325                 330                 335     


Ile Ile Lys Asn Ser Ser Phe Lys Ala Val Ile Tyr Gly Gly Ser Ala 
            340                 345                 350         


Lys Asp Glu Val Gln Ile Ile Asp Gly Asn Leu Gly Asp Leu Arg Asp 
        355                 360                 365             


Ile Leu Lys Lys Gly Ala Thr Phe Asn Arg Glu Thr Pro Gly Val Pro 
    370                 375                 380                 


Ile Ala Tyr Thr Thr Asn Phe Leu Lys Asp Asn Glu Leu Ala Val Ile 
385                 390                 395                 400 


Lys Asn Asn Ser Glu Tyr Ile Glu Thr Thr Ser Lys Ala Tyr Thr Asp 
                405                 410                 415     


Gly Lys Ile Asn Ile Asp His Ser Gly Gly Tyr Val Ala Gln Phe Asn 
            420                 425                 430         


Ile Ser Trp Asp Glu Val Asn Tyr Asp 
        435                 440     


<210>  3
<211>  416
<212>  PRT
<213>  Listeria monocytogenes

<400>  3

Met Lys Lys Ile Met Leu Val Phe Ile Thr Leu Ile Leu Val Ser Leu 
1               5                   10                  15      


Pro Ile Ala Gln Gln Thr Glu Ala Lys Asp Ala Ser Ala Phe Asn Lys 
            20                  25                  30          


Glu Asn Ser Ile Ser Ser Val Ala Pro Pro Ala Ser Pro Pro Ala Ser 
        35                  40                  45              


Pro Lys Thr Pro Ile Glu Lys Lys His Ala Asp Glu Ile Asp Lys Tyr 
    50                  55                  60                  


Ile Gln Gly Leu Asp Tyr Asn Lys Asn Asn Val Leu Val Tyr His Gly 
65                  70                  75                  80  


Asp Ala Val Thr Asn Val Pro Pro Arg Lys Gly Tyr Lys Asp Gly Asn 
                85                  90                  95      


Glu Tyr Ile Val Val Glu Lys Lys Lys Lys Ser Ile Asn Gln Asn Asn 
            100                 105                 110         


Ala Asp Ile Gln Val Val Asn Ala Ile Ser Ser Leu Thr Tyr Pro Gly 
        115                 120                 125             


Ala Leu Val Lys Ala Asn Ser Glu Leu Val Glu Asn Gln Pro Asp Val 
    130                 135                 140                 


Leu Pro Val Lys Arg Asp Ser Leu Thr Leu Ser Ile Asp Leu Pro Gly 
145                 150                 155                 160 


Met Thr Asn Gln Asp Asn Lys Ile Val Val Lys Asn Ala Thr Lys Ser 
                165                 170                 175     


Asn Val Asn Asn Ala Val Asn Thr Leu Val Glu Arg Trp Asn Glu Lys 
            180                 185                 190         


Tyr Ala Gln Ala Tyr Ser Asn Val Ser Ala Lys Ile Asp Tyr Asp Asp 
        195                 200                 205             


Glu Met Ala Tyr Ser Glu Ser Gln Leu Ile Ala Lys Phe Gly Thr Ala 
    210                 215                 220                 


Phe Lys Ala Val Asn Asn Ser Leu Asn Val Asn Phe Gly Ala Ile Ser 
225                 230                 235                 240 


Glu Gly Lys Met Gln Glu Glu Val Ile Ser Phe Lys Gln Ile Tyr Tyr 
                245                 250                 255     


Asn Val Asn Val Asn Glu Pro Thr Arg Pro Ser Arg Phe Phe Gly Lys 
            260                 265                 270         


Ala Val Thr Lys Glu Gln Leu Gln Ala Leu Gly Val Asn Ala Glu Asn 
        275                 280                 285             


Pro Pro Ala Tyr Ile Ser Ser Val Ala Tyr Gly Arg Gln Val Tyr Leu 
    290                 295                 300                 


Lys Leu Ser Thr Asn Ser His Ser Thr Lys Val Lys Ala Ala Phe Asp 
305                 310                 315                 320 


Ala Ala Val Ser Gly Lys Ser Val Ser Gly Asp Val Glu Leu Thr Asn 
                325                 330                 335     


Ile Ile Lys Asn Ser Ser Phe Lys Ala Val Ile Tyr Gly Gly Ser Ala 
            340                 345                 350         


Lys Asp Glu Val Gln Ile Ile Asp Gly Asn Leu Gly Asp Leu Arg Asp 
        355                 360                 365             


Ile Leu Lys Lys Gly Ala Thr Phe Asn Arg Glu Thr Pro Gly Val Pro 
    370                 375                 380                 


Ile Ala Tyr Thr Thr Asn Phe Leu Lys Asp Asn Glu Leu Ala Val Ile 
385                 390                 395                 400 


Lys Asn Asn Ser Glu Tyr Ile Glu Thr Thr Ser Lys Ala Tyr Thr Asp 
                405                 410                 415     


<210>  4
<211>  261
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Trp Val Pro Val Val Phe Leu Thr Leu Ser Val Thr Trp Ile Gly 
1               5                   10                  15      


Ala Ala Pro Leu Ile Leu Ser Arg Ile Val Gly Gly Trp Glu Cys Glu 
            20                  25                  30          


Lys His Ser Gln Pro Trp Gln Val Leu Val Ala Ser Arg Gly Arg Ala 
        35                  40                  45              


Val Cys Gly Gly Val Leu Val His Pro Gln Trp Val Leu Thr Ala Ala 
    50                  55                  60                  


His Cys Ile Arg Asn Lys Ser Val Ile Leu Leu Gly Arg His Ser Leu 
65                  70                  75                  80  


Phe His Pro Glu Asp Thr Gly Gln Val Phe Gln Val Ser His Ser Phe 
                85                  90                  95      


Pro His Pro Leu Tyr Asp Met Ser Leu Leu Lys Asn Arg Phe Leu Arg 
            100                 105                 110         


Pro Gly Asp Asp Ser Ser His Asp Leu Met Leu Leu Arg Leu Ser Glu 
        115                 120                 125             


Pro Ala Glu Leu Thr Asp Ala Val Lys Val Met Asp Leu Pro Thr Gln 
    130                 135                 140                 


Glu Pro Ala Leu Gly Thr Thr Cys Tyr Ala Ser Gly Trp Gly Ser Ile 
145                 150                 155                 160 


Glu Pro Glu Glu Phe Leu Thr Pro Lys Lys Leu Gln Cys Val Asp Leu 
                165                 170                 175     


His Val Ile Ser Asn Asp Val Cys Ala Gln Val His Pro Gln Lys Val 
            180                 185                 190         


Thr Lys Phe Met Leu Cys Ala Gly Arg Trp Thr Gly Gly Lys Ser Thr 
        195                 200                 205             


Cys Ser Gly Asp Ser Gly Gly Pro Leu Val Cys Asn Gly Val Leu Gln 
    210                 215                 220                 


Gly Ile Thr Ser Trp Gly Ser Glu Pro Cys Ala Leu Pro Glu Arg Pro 
225                 230                 235                 240 


Ser Leu Tyr Thr Lys Val Val His Tyr Arg Lys Trp Ile Lys Asp Thr 
                245                 250                 255     


Ile Val Ala Asn Pro 
            260     


<210>  5
<211>  237
<212>  PRT
<213>  Homo sapiens

<400>  5

Ile Val Gly Gly Trp Glu Cys Glu Lys His Ser Gln Pro Trp Gln Val 
1               5                   10                  15      


Leu Val Ala Ser Arg Gly Arg Ala Val Cys Gly Gly Val Leu Val His 
            20                  25                  30          


Pro Gln Trp Val Leu Thr Ala Ala His Cys Ile Arg Asn Lys Ser Val 
        35                  40                  45              


Ile Leu Leu Gly Arg His Ser Leu Phe His Pro Glu Asp Thr Gly Gln 
    50                  55                  60                  


Val Phe Gln Val Ser His Ser Phe Pro His Pro Leu Tyr Asp Met Ser 
65                  70                  75                  80  


Leu Leu Lys Asn Arg Phe Leu Arg Pro Gly Asp Asp Ser Ser His Asp 
                85                  90                  95      


Leu Met Leu Leu Arg Leu Ser Glu Pro Ala Glu Leu Thr Asp Ala Val 
            100                 105                 110         


Lys Val Met Asp Leu Pro Thr Gln Glu Pro Ala Leu Gly Thr Thr Cys 
        115                 120                 125             


Tyr Ala Ser Gly Trp Gly Ser Ile Glu Pro Glu Glu Phe Leu Thr Pro 
    130                 135                 140                 


Lys Lys Leu Gln Cys Val Asp Leu His Val Ile Ser Asn Asp Val Cys 
145                 150                 155                 160 


Ala Gln Val His Pro Gln Lys Val Thr Lys Phe Met Leu Cys Ala Gly 
                165                 170                 175     


Arg Trp Thr Gly Gly Lys Ser Thr Cys Ser Gly Asp Ser Gly Gly Pro 
            180                 185                 190         


Leu Val Cys Tyr Gly Val Leu Gln Gly Ile Thr Ser Trp Gly Ser Glu 
        195                 200                 205             


Pro Cys Ala Leu Pro Glu Arg Pro Ser Leu Tyr Thr Lys Val Val His 
    210                 215                 220                 


Tyr Arg Lys Trp Ile Lys Asp Thr Ile Val Ala Asn Pro 
225                 230                 235         


<210>  6
<211>  237
<212>  PRT
<213>  Homo sapiens

<400>  6

Ile Val Gly Gly Trp Glu Cys Glu Lys His Ser Gln Pro Trp Gln Val 
1               5                   10                  15      


Leu Val Ala Ser Arg Gly Arg Ala Val Cys Gly Gly Val Leu Val His 
            20                  25                  30          


Pro Gln Trp Val Leu Thr Ala Ala His Cys Ile Arg Asn Lys Ser Val 
        35                  40                  45              


Ile Leu Leu Gly Arg His Ser Leu Phe His Pro Glu Asp Thr Gly Gln 
    50                  55                  60                  


Val Phe Gln Val Ser His Ser Phe Pro His Pro Leu Tyr Asp Met Ser 
65                  70                  75                  80  


Leu Leu Lys Asn Arg Phe Leu Arg Pro Gly Asp Asp Ser Ser His Asp 
                85                  90                  95      


Leu Met Leu Leu Arg Leu Ser Glu Pro Ala Glu Leu Thr Asp Ala Val 
            100                 105                 110         


Lys Val Met Asp Leu Pro Thr Gln Glu Pro Ala Leu Gly Thr Thr Cys 
        115                 120                 125             


Tyr Ala Ser Gly Trp Gly Ser Ile Glu Pro Glu Glu Phe Leu Thr Pro 
    130                 135                 140                 


Lys Lys Leu Gln Cys Val Asp Leu His Val Ile Ser Asn Asp Val Cys 
145                 150                 155                 160 


Ala Gln Val His Pro Gln Lys Val Thr Lys Phe Met Leu Cys Ala Gly 
                165                 170                 175     


Arg Trp Thr Gly Gly Lys Ser Thr Cys Ser Gly Asp Ser Gly Gly Pro 
            180                 185                 190         


Leu Val Cys Asn Gly Val Leu Gln Gly Ile Thr Ser Trp Gly Ser Glu 
        195                 200                 205             


Pro Cys Ala Leu Pro Glu Arg Pro Ser Leu Tyr Thr Lys Val Val His 
    210                 215                 220                 


Tyr Arg Lys Trp Ile Lys Asp Thr Ile Val Ala Asn Pro 
225                 230                 235         


<210>  7
<211>  5873
<212>  DNA
<213>  Homo sapiens

<400>  7
ggtgtcttag gcacactggt cttggagtgc aaaggatcta ggcacgtgag gctttgtatg       60

aagaatcggg gatcgtaccc accccctgtt tctgtttcat cctgggcatg tctcctctgc      120

ctttgtcccc tagatgaagt ctccatgagc tacaagggcc tggtgcatcc agggtgatct      180

agtaattgca gaacagcaag tgctagctct ccctcccctt ccacagctct gggtgtggga      240

gggggttgtc cagcctccag cagcatgggg agggccttgg tcagcctctg ggtgccagca      300

gggcaggggc ggagtcctgg ggaatgaagg ttttataggg ctcctggggg aggctcccca      360

gccccaagct taccacctgc acccggagag ctgtgtcacc atgtgggtcc cggttgtctt      420

cctcaccctg tccgtgacgt ggattggtga gaggggccat ggttgggggg atgcaggaga      480

gggagccagc cctgactgtc aagctgaggc tctttccccc ccaacccagc accccagccc      540

agacagggag ctgggctctt ttctgtctct cccagcccca cttcaagccc atacccccag      600

tcccctccat attgcaacag tcctcactcc cacaccaggt ccccgctccc tcccacttac      660

cccagaactt tcttcccatt tgcccagcca gctccctgct cccagctgct ttactaaagg      720

ggaagttcct gggcatctcc gtgtttctct ttgtggggct caaaacctcc aaggacctct      780

ctcaatgcca ttggttcctt ggaccgtatc actggtccat ctcctgagcc cctcaatcct      840

atcacagtct actgactttt cccattcagc tgtgagtgtc caaccctatc ccagagacct      900

tgatgcttgg cctcccaatc ttgccctagg atacccagat gccaaccaga cacctccttc      960

tttcctagcc aggctatctg gcctgagaca acaaatgggt ccctcagtct ggcaatggga     1020

ctctgagaac tcctcattcc ctgactctta gccccagact cttcattcag tggcccacat     1080

tttccttagg aaaaacatga gcatccccag ccacaactgc cagctctctg agtccccaaa     1140

tctgcatcct tttcaaaacc taaaaacaaa aagaaaaaca aataaaacaa aaccaactca     1200

gaccagaact gttttctcaa cctgggactt cctaaacttt ccaaaacctt cctcttccag     1260

caactgaacc tcgccataag gcacttatcc ctggttccta gcacccctta tcccctcaga     1320

atccacaact tgtaccaagt ttcccttctc ccagtccaag accccaaatc accacaaagg     1380

acccaatccc cagactcaag atatggtctg ggcgctgtct tgtgtctcct accctgatcc     1440

ctgggttcaa ctctgctccc agagcatgaa gcctctccac cagcaccagc caccaacctg     1500

caaacctagg gaagattgac agaattccca gcctttccca gctccccctg cccatgtccc     1560

aggactccca gccttggttc tctgcccccg tgtcttttca aacccacatc ctaaatccat     1620

ctcctatccg agtcccccag ttccccctgt caaccctgat tcccctgatc tagcaccccc     1680

tctgcaggcg ctgcgcccct catcctgtct cggattgtgg gaggctggga gtgcgagaag     1740

cattcccaac cctggcaggt gcttgtggcc tctcgtggca gggcagtctg cggcggtgtt     1800

ctggtgcacc cccagtgggt cctcacagct gcccactgca tcaggaagtg agtaggggcc     1860

tggggtctgg ggagcaggtg tctgtgtccc agaggaataa cagctgggca ttttccccag     1920

gataacctct aaggccagcc ttgggactgg gggagagagg gaaagttctg gttcaggtca     1980

catggggagg cagggttggg gctggaccac cctccccatg gctgcctggg tctccatctg     2040

tgtccctcta tgtctctttg tgtcgctttc attatgtctc ttggtaactg gcttcggttg     2100

tgtctctccg tgtgactatt ttgttctctc tctccctctc ttctctgtct tcagtctcca     2160

tatctccccc tctctctgtc cttctctggt ccctctctag ccagtgtgtc tcaccctgta     2220

tctctctgcc aggctctgtc tctcggtctc tgtctcacct gtgccttctc cctactgaac     2280

acacgcacgg gatgggcctg ggggaccctg agaaaaggaa gggctttggc tgggcgcggt     2340

ggctcacacc tgtaatccca gcactttggg aggccaaggc aggtagatca cctgaggtca     2400

ggagttcgag accagcctgg ccaactggtg aaaccccatc tctactaaaa atacaaaaaa     2460

ttagccaggc gtggtggcgc atgcctgtag tcccagctac tcaggagctg agggaggaga     2520

attgcattga acctggaggt tgaggttgca gtgagccgag accgtgccac tgcactccag     2580

cctgggtgac agagtgagac tccgcctcaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaga     2640

aaagaaaaga aaagaaaagg aagtgtttta tccctgatgt gtgtgggtat gagggtatga     2700

gagggcccct ctcactccat tccttctcca ggacatccct ccactcttgg gagacacaga     2760

gaagggctgg ttccagctgg agctgggagg ggcaattgag ggaggaggaa ggagaagggg     2820

gaaggaaaac agggtatggg ggaaaggacc ctggggagcg aagtggagga tacaaccttg     2880

ggcctgcagg caggctacct acccacttgg aaacccacgc caaagccgca tctacagctg     2940

agccactctg aggcctcccc tccccggcgg tccccactca gctccaaagt ctctctccct     3000

tttctctccc acactttatc atcccccgga ttcctctcta cttggttctc attcttcctt     3060

tgacttcctg cttccctttc tcattcatct gtttctcact ttctgcctgg ttttgttctt     3120

ctctctctct ttctctggcc catgtctgtt tctctatgtt tctgtctttt ctttctcatc     3180

ctgtgtattt tcggctcacc ttgtttgtca ctgttctccc ctctgccctt tcattctctc     3240

tgccctttta ccctcttcct tttcccttgg ttctctcagt tctgtatctg cccttcaccc     3300

tctcacactg ctgtttccca actcgttgtc tgtattttgg cctgaactgt gtcttcccaa     3360

ccctgtgttt tctcactgtt tctttttctc ttttggagcc tcctccttgc tcctctgtcc     3420

cttctctctt tccttatcat cctcgctcct cattcctgcg tctgcttcct ccccagcaaa     3480

agcgtgatct tgctgggtcg gcacagcctg tttcatcctg aagacacagg ccaggtattt     3540

caggtcagcc acagcttccc acacccgctc tacgatatga gcctcctgaa gaatcgattc     3600

ctcaggccag gtgatgactc cagccacgac ctcatgctgc tccgcctgtc agagcctgcc     3660

gagctcacgg atgctgtgaa ggtcatggac ctgcccaccc aggagccagc actggggacc     3720

acctgctacg cctcaggctg gggcagcatt gaaccagagg agtgtacgcc tgggccagat     3780

ggtgcagccg ggagcccaga tgcctgggtc tgagggagga ggggacagga ctcctgggtc     3840

tgagggagga gggccaagga accaggtggg gtccagccca caacagtgtt tttgcctggc     3900

ccgtagtctt gaccccaaag aaacttcagt gtgtggacct ccatgttatt tccaatgacg     3960

tgtgtgcgca agttcaccct cagaaggtga ccaagttcat gctgtgtgct ggacgctgga     4020

cagggggcaa aagcacctgc tcggtgagtc atccctactc ccaagatctt gagggaaagg     4080

tgagtgggac cttaattctg ggctggggtc tagaagccaa caaggcgtct gcctcccctg     4140

ctccccagct gtagccatgc cacctccccg tgtctcatct cattccctcc ttccctcttc     4200

tttgactccc tcaaggcaat aggttattct tacagcacaa ctcatctgtt cctgcgttca     4260

gcacacggtt actaggcacc tgctatgcac ccagcactgc cctagagcct gggacatagc     4320

agtgaacaga cagagagcag cccctccctt ctgtagcccc caagccagtg aggggcacag     4380

gcaggaacag ggaccacaac acagaaaagc tggagggtgt caggaggtga tcaggctctc     4440

ggggagggag aaggggtggg gagtgtgact gggaggagac atcctgcaga aggtgggagt     4500

gagcaaacac ctgcgcaggg gaggggaggg cctgcggcac ctgggggagc agagggaaca     4560

gcatctggcc aggcctggga ggaggggcct agagggcgtc aggagcagag aggaggttgc     4620

ctggctggag tgaaggatcg gggcagggtg cgagagggaa caaaggaccc ctcctgcagg     4680

gcctcacctg ggccacagga ggacactgct tttcctctga ggagtcagga actgtggatg     4740

gtgctggaca gaagcaggac agggcctggc tcaggtgtcc agaggctgcg ctggcctcct     4800

atgggatcag actgcaggga gggagggcag cagggatgtg gagggagtga tgatggggct     4860

gacctggggg tggctccagg cattgtcccc acctgggccc ttacccagcc tccctcacag     4920

gctcctggcc ctcagtctct cccctccact ccattctcca cctacccaca gtgggtcatt     4980

ctgatcaccg aactgaccat gccagccctg ccgatggtcc tccatggctc cctagtgccc     5040

tggagaggag gtgtctagtc agagagtagt cctggaaggt ggcctctgtg aggagccacg     5100

gggacagcat cctgcagatg gtcctggccc ttgtcccacc gacctgtcta caaggactgt     5160

cctcgtggac cctcccctct gcacaggagc tggaccctga agtcccttcc taccggccag     5220

gactggagcc cctacccctc tgttggaatc cctgcccacc ttcttctgga agtcggctct     5280

ggagacattt ctctcttctt ccaaagctgg gaactgctat ctgttatctg cctgtccagg     5340

tctgaaagat aggattgccc aggcagaaac tgggactgac ctatctcact ctctccctgc     5400

ttttaccctt agggtgattc tgggggccca cttgtctgta atggtgtgct tcaaggtatc     5460

acgtcatggg gcagtgaacc atgtgccctg cccgaaaggc cttccctgta caccaaggtg     5520

gtgcattacc ggaagtggat caaggacacc atcgtggcca acccctgagc acccctatca     5580

agtccctatt gtagtaaact tggaaccttg gaaatgacca ggccaagact caagcctccc     5640

cagttctact gacctttgtc cttaggtgtg aggtccaggg ttgctaggaa aagaaatcag     5700

cagacacagg tgtagaccag agtgtttctt aaatggtgta attttgtcct ctctgtgtcc     5760

tggggaatac tggccatgcc tggagacata tcactcaatt tctctgagga cacagttagg     5820

atggggtgtc tgtgttattt gtgggataca gagatgaaag aggggtggga tcc            5873


<210>  8
<211>  238
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Trp Val Pro Val Val Phe Leu Thr Leu Ser Val Thr Trp Ile Gly 
1               5                   10                  15      


Ala Ala Pro Leu Ile Leu Ser Arg Ile Val Gly Gly Trp Glu Cys Glu 
            20                  25                  30          


Lys His Ser Gln Pro Trp Gln Val Leu Val Ala Ser Arg Gly Arg Ala 
        35                  40                  45              


Val Cys Gly Gly Val Leu Val His Pro Gln Trp Val Leu Thr Ala Ala 
    50                  55                  60                  


His Cys Ile Arg Asn Lys Ser Val Ile Leu Leu Gly Arg His Ser Leu 
65                  70                  75                  80  


Phe His Pro Glu Asp Thr Gly Gln Val Phe Gln Val Ser His Ser Phe 
                85                  90                  95      


Pro His Pro Leu Tyr Asp Met Ser Leu Leu Lys Asn Arg Phe Leu Arg 
            100                 105                 110         


Pro Gly Asp Asp Ser Ser His Asp Leu Met Leu Leu Arg Leu Ser Glu 
        115                 120                 125             


Pro Ala Glu Leu Thr Asp Ala Val Lys Val Met Asp Leu Pro Thr Gln 
    130                 135                 140                 


Glu Pro Ala Leu Gly Thr Thr Cys Tyr Ala Ser Gly Trp Gly Ser Ile 
145                 150                 155                 160 


Glu Pro Glu Glu Phe Leu Thr Pro Lys Lys Leu Gln Cys Val Asp Leu 
                165                 170                 175     


His Val Ile Ser Asn Asp Val Cys Ala Gln Val His Pro Gln Lys Val 
            180                 185                 190         


Thr Lys Phe Met Leu Cys Ala Gly Arg Trp Thr Gly Gly Lys Ser Thr 
        195                 200                 205             


Cys Ser Trp Val Ile Leu Ile Thr Glu Leu Thr Met Pro Ala Leu Pro 
    210                 215                 220                 


Met Val Leu His Gly Ser Leu Val Pro Trp Arg Gly Gly Val 
225                 230                 235             


<210>  9
<211>  1906
<212>  DNA
<213>  Homo sapiens

<400>  9
agccccaagc ttaccacctg cacccggaga gctgtgtcac catgtgggtc ccggttgtct       60

tcctcaccct gtccgtgacg tggattggtg ctgcacccct catcctgtct cggattgtgg      120

gaggctggga gtgcgagaag cattcccaac cctggcaggt gcttgtggcc tctcgtggca      180

gggcagtctg cggcggtgtt ctggtgcacc cccagtgggt cctcacagct gcccactgca      240

tcaggaacaa aagcgtgatc ttgctgggtc ggcacagcct gtttcatcct gaagacacag      300

gccaggtatt tcaggtcagc cacagcttcc cacacccgct ctacgatatg agcctcctga      360

agaatcgatt cctcaggcca ggtgatgact ccagccacga cctcatgctg ctccgcctgt      420

cagagcctgc cgagctcacg gatgctgtga aggtcatgga cctgcccacc caggagccag      480

cactggggac cacctgctac gcctcaggct ggggcagcat tgaaccagag gagttcttga      540

ccccaaagaa acttcagtgt gtggacctcc atgttatttc caatgacgtg tgtgcgcaag      600

ttcaccctca gaaggtgacc aagttcatgc tgtgtgctgg acgctggaca gggggcaaaa      660

gcacctgctc gtgggtcatt ctgatcaccg aactgaccat gccagccctg ccgatggtcc      720

tccatggctc cctagtgccc tggagaggag gtgtctagtc agagagtagt cctggaaggt      780

ggcctctgtg aggagccacg gggacagcat cctgcagatg gtcctggccc ttgtcccacc      840

gacctgtcta caaggactgt cctcgtggac cctcccctct gcacaggagc tggaccctga      900

agtcccttcc ccaccggcca ggactggagc ccctacccct ctgttggaat ccctgcccac      960

cttcttctgg aagtcggctc tggagacatt tctctcttct tccaaagctg ggaactgcta     1020

tctgttatct gcctgtccag gtctgaaaga taggattgcc caggcagaaa ctgggactga     1080

cctatctcac tctctccctg cttttaccct tagggtgatt ctgggggccc acttgtctgt     1140

aatggtgtgc ttcaaggtat cacgtcatgg ggcagtgaac catgtgccct gcccgaaagg     1200

ccttccctgt acaccaaggt ggtgcattac cggaagtgga tcaaggacac catcgtggcc     1260

aacccctgag cacccctatc aaccccctat tgtagtaaac ttggaacctt ggaaatgacc     1320

aggccaagac tcaagcctcc ccagttctac tgacctttgt ccttaggtgt gaggtccagg     1380

gttgctagga aaagaaatca gcagacacag gtgtagacca gagtgtttct taaatggtgt     1440

aattttgtcc tctctgtgtc ctggggaata ctggccatgc ctggagacat atcactcaat     1500

ttctctgagg acacagatag gatggggtgt ctgtgttatt tgtggggtac agagatgaaa     1560

gaggggtggg atccacactg agagagtgga gagtgacatg tgctggacac tgtccatgaa     1620

gcactgagca gaagctggag gcacaacgca ccagacactc acagcaagga tggagctgaa     1680

aacataaccc actctgtcct ggaggcactg ggaagcctag agaaggctgt gagccaagga     1740

gggagggtct tcctttggca tgggatgggg atgaagtaag gagagggact ggaccccctg     1800

gaagctgatt cactatgggg ggaggtgtat tgaagtcctc cagacaaccc tcagatttga     1860

tgatttccta gtagaactca cagaaataaa gagctgttat actgtg                    1906


<210>  10
<211>  711
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleotide molecule encoding KLK3 protein

<400>  10
attgtgggag gctgggagtg cgagaagcat tcccaaccct ggcaggtgct tgtggcctct       60

cgtggcaggg cagtctgcgg cggtgttctg gtgcaccccc agtgggtcct cacagctgcc      120

cactgcatca ggaacaaaag cgtgatcttg ctgggtcggc acagcctgtt tcatcctgaa      180

gacacaggcc aggtatttca ggtcagccac agcttcccac acccgctcta cgatatgagc      240

ctcctgaaga atcgattcct caggccaggt gatgactcca gccacgacct catgctgctc      300

cgcctgtcag agcctgccga gctcacggat gctgtgaagg tcatggacct gcccacccag      360

gagccagcac tggggaccac ctgctacgcc tcaggctggg gcagcattga accagaggag      420

ttcttgaccc caaagaaact tcagtgtgtg gacctccatg ttatttccaa tgacgtgtgt      480

gcgcaagttc accctcagaa ggtgaccaag ttcatgctgt gtgctggacg ctggacaggg      540

ggcaaaagca cctgctcggg tgattctggg ggcccacttg tctgttatgg tgtgcttcaa      600

ggtatcacgt catggggcag tgaaccatgt gccctgcccg aaaggccttc cctgtacacc      660

aaggtggtgc attaccggaa gtggatcaag gacaccatcg tggccaaccc c               711


<210>  11
<211>  24
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Trp Val Pro Val Val Phe Leu Thr Leu Ser Val Thr Trp Ile Gly 
1               5                   10                  15      


Ala Ala Pro Leu Ile Leu Ser Arg 
            20                  


<210>  12
<211>  2040
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sequence encoding truncated LLO fused to a PSA protein

<400>  12
atgaaaaaaa taatgctagt ttttattaca cttatattag ttagtctacc aattgcgcaa       60

caaactgaag caaaggatgc atctgcattc aataaagaaa attcaatttc atccatggca      120

ccaccagcat ctccgcctgc aagtcctaag acgccaatcg aaaagaaaca cgcggatgaa      180

atcgataagt atatacaagg attggattac aataaaaaca atgtattagt ataccacgga      240

gatgcagtga caaatgtgcc gccaagaaaa ggttacaaag atggaaatga atatattgtt      300

gtggagaaaa agaagaaatc catcaatcaa aataatgcag acattcaagt tgtgaatgca      360

atttcgagcc taacctatcc aggtgctctc gtaaaagcga attcggaatt agtagaaaat      420

caaccagatg ttctccctgt aaaacgtgat tcattaacac tcagcattga tttgccaggt      480

atgactaatc aagacaataa aatagttgta aaaaatgcca ctaaatcaaa cgttaacaac      540

gcagtaaata cattagtgga aagatggaat gaaaaatatg ctcaagctta tccaaatgta      600

agtgcaaaaa ttgattatga tgacgaaatg gcttacagtg aatcacaatt aattgcgaaa      660

tttggtacag catttaaagc tgtaaataat agcttgaatg taaacttcgg cgcaatcagt      720

gaagggaaaa tgcaagaaga agtcattagt tttaaacaaa tttactataa cgtgaatgtt      780

aatgaaccta caagaccttc cagatttttc ggcaaagctg ttactaaaga gcagttgcaa      840

gcgcttggag tgaatgcaga aaatcctcct gcatatatct caagtgtggc gtatggccgt      900

caagtttatt tgaaattatc aactaattcc catagtacta aagtaaaagc tgcttttgat      960

gctgccgtaa gcggaaaatc tgtctcaggt gatgtagaac taacaaatat catcaaaaat     1020

tcttccttca aagccgtaat ttacggaggt tccgcaaaag atgaagttca aatcatcgac     1080

ggcaacctcg gagacttacg cgatattttg aaaaaaggcg ctacttttaa tcgagaaaca     1140

ccaggagttc ccattgctta tacaacaaac ttcctaaaag acaatgaatt agctgttatt     1200

aaaaacaact cagaatatat tgaaacaact tcaaaagctt atacagatgg aaaaattaac     1260

atcgatcact ctggaggata cgttgctcaa ttcaacattt cttgggatga agtaaattat     1320

gatctcgaga ttgtgggagg ctgggagtgc gagaagcatt cccaaccctg gcaggtgctt     1380

gtggcctctc gtggcagggc agtctgcggc ggtgttctgg tgcaccccca gtgggtcctc     1440

acagctgccc actgcatcag gaacaaaagc gtgatcttgc tgggtcggca cagcctgttt     1500

catcctgaag acacaggcca ggtatttcag gtcagccaca gcttcccaca cccgctctac     1560

gatatgagcc tcctgaagaa tcgattcctc aggccaggtg atgactccag ccacgacctc     1620

atgctgctcc gcctgtcaga gcctgccgag ctcacggatg ctgtgaaggt catggacctg     1680

cccacccagg agccagcact ggggaccacc tgctacgcct caggctgggg cagcattgaa     1740

ccagaggagt tcttgacccc aaagaaactt cagtgtgtgg acctccatgt tatttccaat     1800

gacgtgtgtg cgcaagttca ccctcagaag gtgaccaagt tcatgctgtg tgctggacgc     1860

tggacagggg gcaaaagcac ctgctcgggt gattctgggg gcccacttgt ctgttatggt     1920

gtgcttcaag gtatcacgtc atggggcagt gaaccatgtg ccctgcccga aaggccttcc     1980

ctgtacacca aggtggtgca ttaccggaag tggatcaagg acaccatcgt ggccaacccc     2040


<210>  13
<211>  680
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  truncated LLO fused to a PSA protein

<400>  13

Met Lys Lys Ile Met Leu Val Phe Ile Thr Leu Ile Leu Val Ser Leu 
1               5                   10                  15      


Pro Ile Ala Gln Gln Thr Glu Ala Lys Asp Ala Ser Ala Phe Asn Lys 
            20                  25                  30          


Glu Asn Ser Ile Ser Ser Met Ala Pro Pro Ala Ser Pro Pro Ala Ser 
        35                  40                  45              


Pro Lys Thr Pro Ile Glu Lys Lys His Ala Asp Glu Ile Asp Lys Tyr 
    50                  55                  60                  


Ile Gln Gly Leu Asp Tyr Asn Lys Asn Asn Val Leu Val Tyr His Gly 
65                  70                  75                  80  


Asp Ala Val Thr Asn Val Pro Pro Arg Lys Gly Tyr Lys Asp Gly Asn 
                85                  90                  95      


Glu Tyr Ile Val Val Glu Lys Lys Lys Lys Ser Ile Asn Gln Asn Asn 
            100                 105                 110         


Ala Asp Ile Gln Val Val Asn Ala Ile Ser Ser Leu Thr Tyr Pro Gly 
        115                 120                 125             


Ala Leu Val Lys Ala Asn Ser Glu Leu Val Glu Asn Gln Pro Asp Val 
    130                 135                 140                 


Leu Pro Val Lys Arg Asp Ser Leu Thr Leu Ser Ile Asp Leu Pro Gly 
145                 150                 155                 160 


Met Thr Asn Gln Asp Asn Lys Ile Val Val Lys Asn Ala Thr Lys Ser 
                165                 170                 175     


Asn Val Asn Asn Ala Val Asn Thr Leu Val Glu Arg Trp Asn Glu Lys 
            180                 185                 190         


Tyr Ala Gln Ala Tyr Pro Asn Val Ser Ala Lys Ile Asp Tyr Asp Asp 
        195                 200                 205             


Glu Met Ala Tyr Ser Glu Ser Gln Leu Ile Ala Lys Phe Gly Thr Ala 
    210                 215                 220                 


Phe Lys Ala Val Asn Asn Ser Leu Asn Val Asn Phe Gly Ala Ile Ser 
225                 230                 235                 240 


Glu Gly Lys Met Gln Glu Glu Val Ile Ser Phe Lys Gln Ile Tyr Tyr 
                245                 250                 255     


Asn Val Asn Val Asn Glu Pro Thr Arg Pro Ser Arg Phe Phe Gly Lys 
            260                 265                 270         


Ala Val Thr Lys Glu Gln Leu Gln Ala Leu Gly Val Asn Ala Glu Asn 
        275                 280                 285             


Pro Pro Ala Tyr Ile Ser Ser Val Ala Tyr Gly Arg Gln Val Tyr Leu 
    290                 295                 300                 


Lys Leu Ser Thr Asn Ser His Ser Thr Lys Val Lys Ala Ala Phe Asp 
305                 310                 315                 320 


Ala Ala Val Ser Gly Lys Ser Val Ser Gly Asp Val Glu Leu Thr Asn 
                325                 330                 335     


Ile Ile Lys Asn Ser Ser Phe Lys Ala Val Ile Tyr Gly Gly Ser Ala 
            340                 345                 350         


Lys Asp Glu Val Gln Ile Ile Asp Gly Asn Leu Gly Asp Leu Arg Asp 
        355                 360                 365             


Ile Leu Lys Lys Gly Ala Thr Phe Asn Arg Glu Thr Pro Gly Val Pro 
    370                 375                 380                 


Ile Ala Tyr Thr Thr Asn Phe Leu Lys Asp Asn Glu Leu Ala Val Ile 
385                 390                 395                 400 


Lys Asn Asn Ser Glu Tyr Ile Glu Thr Thr Ser Lys Ala Tyr Thr Asp 
                405                 410                 415     


Gly Lys Ile Asn Ile Asp His Ser Gly Gly Tyr Val Ala Gln Phe Asn 
            420                 425                 430         


Ile Ser Trp Asp Glu Val Asn Tyr Asp Leu Glu Ile Val Gly Gly Trp 
        435                 440                 445             


Glu Cys Glu Lys His Ser Gln Pro Trp Gln Val Leu Val Ala Ser Arg 
    450                 455                 460                 


Gly Arg Ala Val Cys Gly Gly Val Leu Val His Pro Gln Trp Val Leu 
465                 470                 475                 480 


Thr Ala Ala His Cys Ile Arg Asn Lys Ser Val Ile Leu Leu Gly Arg 
                485                 490                 495     


His Ser Leu Phe His Pro Glu Asp Thr Gly Gln Val Phe Gln Val Ser 
            500                 505                 510         


His Ser Phe Pro His Pro Leu Tyr Asp Met Ser Leu Leu Lys Asn Arg 
        515                 520                 525             


Phe Leu Arg Pro Gly Asp Asp Ser Ser His Asp Leu Met Leu Leu Arg 
    530                 535                 540                 


Leu Ser Glu Pro Ala Glu Leu Thr Asp Ala Val Lys Val Met Asp Leu 
545                 550                 555                 560 


Pro Thr Gln Glu Pro Ala Leu Gly Thr Thr Cys Tyr Ala Ser Gly Trp 
                565                 570                 575     


Gly Ser Ile Glu Pro Glu Glu Phe Leu Thr Pro Lys Lys Leu Gln Cys 
            580                 585                 590         


Val Asp Leu His Val Ile Ser Asn Asp Val Cys Ala Gln Val His Pro 
        595                 600                 605             


Gln Lys Val Thr Lys Phe Met Leu Cys Ala Gly Arg Trp Thr Gly Gly 
    610                 615                 620                 


Lys Ser Thr Cys Ser Gly Asp Ser Gly Gly Pro Leu Val Cys Tyr Gly 
625                 630                 635                 640 


Val Leu Gln Gly Ile Thr Ser Trp Gly Ser Glu Pro Cys Ala Leu Pro 
                645                 650                 655     


Glu Arg Pro Ser Leu Tyr Thr Lys Val Val His Tyr Arg Lys Trp Ile 
            660                 665                 670         


Lys Asp Thr Ile Val Ala Asn Pro 
        675                 680 


<210>  14
<211>  1257
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sequence encoding chimeric HER2 protein

<400>  14
acccacctgg acatgctccg ccacctctac cagggctgcc aggtggtgca gggaaacctg       60

gaactcacct acctgcccac caatgccagc ctgtccttcc tgcaggatat ccaggaggtg      120

cagggctacg tgctcatcgc tcacaaccaa gtgaggcagg tcccactgca gaggctgcgg      180

attgtgcgag gcacccagct ctttgaggac aactatgccc tggccgtgct agacaatgga      240

gacccgctga acaataccac ccctgtcaca ggggcctccc caggaggcct gcgggagctg      300

cagcttcgaa gcctcacaga gatcttgaaa ggaggggtct tgatccagcg gaacccccag      360

ctctgctacc aggacacgat tttgtggaag aatatccagg agtttgctgg ctgcaagaag      420

atctttggga gcctggcatt tctgccggag agctttgatg gggacccagc ctccaacact      480

gccccgctcc agccagagca gctccaagtg tttgagactc tggaagagat cacaggttac      540

ctatacatct cagcatggcc ggacagcctg cctgacctca gcgtcttcca gaacctgcaa      600

gtaatccggg gacgaattct gcacaatggc gcctactcgc tgaccctgca agggctgggc      660

atcagctggc tggggctgcg ctcactgagg gaactgggca gtggactggc cctcatccac      720

cataacaccc acctctgctt cgtgcacacg gtgccctggg accagctctt tcggaacccg      780

caccaagctc tgctccacac tgccaaccgg ccagaggacg agtgtgtggg cgagggcctg      840

gcctgccacc agctgtgcgc ccgagggcag cagaagatcc ggaagtacac gatgcggaga      900

ctgctgcagg aaacggagct ggtggagccg ctgacaccta gcggagcgat gcccaaccag      960

gcgcagatgc ggatcctgaa agagacggag ctgaggaagg tgaaggtgct tggatctggc     1020

gcttttggca cagtctacaa gggcatctgg atccctgatg gggagaatgt gaaaattcca     1080

gtggccatca aagtgttgag ggaaaacaca tcccccaaag ccaacaaaga aatcttagac     1140

gaagcatacg tgatggctgg tgtgggctcc ccatatgtct cccgccttct gggcatctgc     1200

ctgacatcca cggtgcagct ggtgacacag cttatgccct atggctgcct cttagac        1257


<210>  15
<211>  419
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chimeric HER2 protein

<400>  15

Thr His Leu Asp Met Leu Arg His Leu Tyr Gln Gly Cys Gln Val Val 
1               5                   10                  15      


Gln Gly Asn Leu Glu Leu Thr Tyr Leu Pro Thr Asn Ala Ser Leu Ser 
            20                  25                  30          


Phe Leu Gln Asp Ile Gln Glu Val Gln Gly Tyr Val Leu Ile Ala His 
        35                  40                  45              


Asn Gln Val Arg Gln Val Pro Leu Gln Arg Leu Arg Ile Val Arg Gly 
    50                  55                  60                  


Thr Gln Leu Phe Glu Asp Asn Tyr Ala Leu Ala Val Leu Asp Asn Gly 
65                  70                  75                  80  


Asp Pro Leu Asn Asn Thr Thr Pro Val Thr Gly Ala Ser Pro Gly Gly 
                85                  90                  95      


Leu Arg Glu Leu Gln Leu Arg Ser Leu Thr Glu Ile Leu Lys Gly Gly 
            100                 105                 110         


Val Leu Ile Gln Arg Asn Pro Gln Leu Cys Tyr Gln Asp Thr Ile Leu 
        115                 120                 125             


Trp Lys Asn Ile Gln Glu Phe Ala Gly Cys Lys Lys Ile Phe Gly Ser 
    130                 135                 140                 


Leu Ala Phe Leu Pro Glu Ser Phe Asp Gly Asp Pro Ala Ser Asn Thr 
145                 150                 155                 160 


Ala Pro Leu Gln Pro Glu Gln Leu Gln Val Phe Glu Thr Leu Glu Glu 
                165                 170                 175     


Ile Thr Gly Tyr Leu Tyr Ile Ser Ala Trp Pro Asp Ser Leu Pro Asp 
            180                 185                 190         


Leu Ser Val Phe Gln Asn Leu Gln Val Ile Arg Gly Arg Ile Leu His 
        195                 200                 205             


Asn Gly Ala Tyr Ser Leu Thr Leu Gln Gly Leu Gly Ile Ser Trp Leu 
    210                 215                 220                 


Gly Leu Arg Ser Leu Arg Glu Leu Gly Ser Gly Leu Ala Leu Ile His 
225                 230                 235                 240 


His Asn Thr His Leu Cys Phe Val His Thr Val Pro Trp Asp Gln Leu 
                245                 250                 255     


Phe Arg Asn Pro His Gln Ala Leu Leu His Thr Ala Asn Arg Pro Glu 
            260                 265                 270         


Asp Glu Cys Val Gly Glu Gly Leu Ala Cys His Gln Leu Cys Ala Arg 
        275                 280                 285             


Gly Gln Gln Lys Ile Arg Lys Tyr Thr Met Arg Arg Leu Leu Gln Glu 
    290                 295                 300                 


Thr Glu Leu Val Glu Pro Leu Thr Pro Ser Gly Ala Met Pro Asn Gln 
305                 310                 315                 320 


Ala Gln Met Arg Ile Leu Lys Glu Thr Glu Leu Arg Lys Val Lys Val 
                325                 330                 335     


Leu Gly Ser Gly Ala Phe Gly Thr Val Tyr Lys Gly Ile Trp Ile Pro 
            340                 345                 350         


Asp Gly Glu Asn Val Lys Ile Pro Val Ala Ile Lys Val Leu Arg Glu 
        355                 360                 365             


Asn Thr Ser Pro Lys Ala Asn Lys Glu Ile Leu Asp Glu Ala Tyr Val 
    370                 375                 380                 


Met Ala Gly Val Gly Ser Pro Tyr Val Ser Arg Leu Leu Gly Ile Cys 
385                 390                 395                 400 


Leu Thr Ser Thr Val Gln Leu Val Thr Gln Leu Met Pro Tyr Gly Cys 
                405                 410                 415     


Leu Leu Asp 
            


<210>  16
<211>  2586
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sequence encoding truncated LLO fused to a cHER2 protein

<400>  16
atgaaaaaaa taatgctagt ttttattaca cttatattag ttagtctacc aattgcgcaa       60

caaactgaag caaaggatgc atctgcattc aataaagaaa attcaatttc atccatggca      120

ccaccagcat ctccgcctgc aagtcctaag acgccaatcg aaaagaaaca cgcggatgaa      180

atcgataagt atatacaagg attggattac aataaaaaca atgtattagt ataccacgga      240

gatgcagtga caaatgtgcc gccaagaaaa ggttacaaag atggaaatga atatattgtt      300

gtggagaaaa agaagaaatc catcaatcaa aataatgcag acattcaagt tgtgaatgca      360

atttcgagcc taacctatcc aggtgctctc gtaaaagcga attcggaatt agtagaaaat      420

caaccagatg ttctccctgt aaaacgtgat tcattaacac tcagcattga tttgccaggt      480

atgactaatc aagacaataa aatagttgta aaaaatgcca ctaaatcaaa cgttaacaac      540

gcagtaaata cattagtgga aagatggaat gaaaaatatg ctcaagctta tccaaatgta      600

agtgcaaaaa ttgattatga tgacgaaatg gcttacagtg aatcacaatt aattgcgaaa      660

tttggtacag catttaaagc tgtaaataat agcttgaatg taaacttcgg cgcaatcagt      720

gaagggaaaa tgcaagaaga agtcattagt tttaaacaaa tttactataa cgtgaatgtt      780

aatgaaccta caagaccttc cagatttttc ggcaaagctg ttactaaaga gcagttgcaa      840

gcgcttggag tgaatgcaga aaatcctcct gcatatatct caagtgtggc gtatggccgt      900

caagtttatt tgaaattatc aactaattcc catagtacta aagtaaaagc tgcttttgat      960

gctgccgtaa gcggaaaatc tgtctcaggt gatgtagaac taacaaatat catcaaaaat     1020

tcttccttca aagccgtaat ttacggaggt tccgcaaaag atgaagttca aatcatcgac     1080

ggcaacctcg gagacttacg cgatattttg aaaaaaggcg ctacttttaa tcgagaaaca     1140

ccaggagttc ccattgctta tacaacaaac ttcctaaaag acaatgaatt agctgttatt     1200

aaaaacaact cagaatatat tgaaacaact tcaaaagctt atacagatgg aaaaattaac     1260

atcgatcact ctggaggata cgttgctcaa ttcaacattt cttgggatga agtaaattat     1320

gatctcgaga cccacctgga catgctccgc cacctctacc agggctgcca ggtggtgcag     1380

ggaaacctgg aactcaccta cctgcccacc aatgccagcc tgtccttcct gcaggatatc     1440

caggaggtgc agggctacgt gctcatcgct cacaaccaag tgaggcaggt cccactgcag     1500

aggctgcgga ttgtgcgagg cacccagctc tttgaggaca actatgccct ggccgtgcta     1560

gacaatggag acccgctgaa caataccacc cctgtcacag gggcctcccc aggaggcctg     1620

cgggagctgc agcttcgaag cctcacagag atcttgaaag gaggggtctt gatccagcgg     1680

aacccccagc tctgctacca ggacacgatt ttgtggaaga atatccagga gtttgctggc     1740

tgcaagaaga tctttgggag cctggcattt ctgccggaga gctttgatgg ggacccagcc     1800

tccaacactg ccccgctcca gccagagcag ctccaagtgt ttgagactct ggaagagatc     1860

acaggttacc tatacatctc agcatggccg gacagcctgc ctgacctcag cgtcttccag     1920

aacctgcaag taatccgggg acgaattctg cacaatggcg cctactcgct gaccctgcaa     1980

gggctgggca tcagctggct ggggctgcgc tcactgaggg aactgggcag tggactggcc     2040

ctcatccacc ataacaccca cctctgcttc gtgcacacgg tgccctggga ccagctcttt     2100

cggaacccgc accaagctct gctccacact gccaaccggc cagaggacga gtgtgtgggc     2160

gagggcctgg cctgccacca gctgtgcgcc cgagggcagc agaagatccg gaagtacacg     2220

atgcggagac tgctgcagga aacggagctg gtggagccgc tgacacctag cggagcgatg     2280

cccaaccagg cgcagatgcg gatcctgaaa gagacggagc tgaggaaggt gaaggtgctt     2340

ggatctggcg cttttggcac agtctacaag ggcatctgga tccctgatgg ggagaatgtg     2400

aaaattccag tggccatcaa agtgttgagg gaaaacacat cccccaaagc caacaaagaa     2460

atcttagacg aagcatacgt gatggctggt gtgggctccc catatgtctc ccgccttctg     2520

ggcatctgcc tgacatccac ggtgcagctg gtgacacagc ttatgcccta tggctgcctc     2580

ttagac                                                                2586


<210>  17
<211>  862
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  truncated LLO fused to a cHER2 protein

<400>  17

Met Lys Lys Ile Met Leu Val Phe Ile Thr Leu Ile Leu Val Ser Leu 
1               5                   10                  15      


Pro Ile Ala Gln Gln Thr Glu Ala Lys Asp Ala Ser Ala Phe Asn Lys 
            20                  25                  30          


Glu Asn Ser Ile Ser Ser Met Ala Pro Pro Ala Ser Pro Pro Ala Ser 
        35                  40                  45              


Pro Lys Thr Pro Ile Glu Lys Lys His Ala Asp Glu Ile Asp Lys Tyr 
    50                  55                  60                  


Ile Gln Gly Leu Asp Tyr Asn Lys Asn Asn Val Leu Val Tyr His Gly 
65                  70                  75                  80  


Asp Ala Val Thr Asn Val Pro Pro Arg Lys Gly Tyr Lys Asp Gly Asn 
                85                  90                  95      


Glu Tyr Ile Val Val Glu Lys Lys Lys Lys Ser Ile Asn Gln Asn Asn 
            100                 105                 110         


Ala Asp Ile Gln Val Val Asn Ala Ile Ser Ser Leu Thr Tyr Pro Gly 
        115                 120                 125             


Ala Leu Val Lys Ala Asn Ser Glu Leu Val Glu Asn Gln Pro Asp Val 
    130                 135                 140                 


Leu Pro Val Lys Arg Asp Ser Leu Thr Leu Ser Ile Asp Leu Pro Gly 
145                 150                 155                 160 


Met Thr Asn Gln Asp Asn Lys Ile Val Val Lys Asn Ala Thr Lys Ser 
                165                 170                 175     


Asn Val Asn Asn Ala Val Asn Thr Leu Val Glu Arg Trp Asn Glu Lys 
            180                 185                 190         


Tyr Ala Gln Ala Tyr Pro Asn Val Ser Ala Lys Ile Asp Tyr Asp Asp 
        195                 200                 205             


Glu Met Ala Tyr Ser Glu Ser Gln Leu Ile Ala Lys Phe Gly Thr Ala 
    210                 215                 220                 


Phe Lys Ala Val Asn Asn Ser Leu Asn Val Asn Phe Gly Ala Ile Ser 
225                 230                 235                 240 


Glu Gly Lys Met Gln Glu Glu Val Ile Ser Phe Lys Gln Ile Tyr Tyr 
                245                 250                 255     


Asn Val Asn Val Asn Glu Pro Thr Arg Pro Ser Arg Phe Phe Gly Lys 
            260                 265                 270         


Ala Val Thr Lys Glu Gln Leu Gln Ala Leu Gly Val Asn Ala Glu Asn 
        275                 280                 285             


Pro Pro Ala Tyr Ile Ser Ser Val Ala Tyr Gly Arg Gln Val Tyr Leu 
    290                 295                 300                 


Lys Leu Ser Thr Asn Ser His Ser Thr Lys Val Lys Ala Ala Phe Asp 
305                 310                 315                 320 


Ala Ala Val Ser Gly Lys Ser Val Ser Gly Asp Val Glu Leu Thr Asn 
                325                 330                 335     


Ile Ile Lys Asn Ser Ser Phe Lys Ala Val Ile Tyr Gly Gly Ser Ala 
            340                 345                 350         


Lys Asp Glu Val Gln Ile Ile Asp Gly Asn Leu Gly Asp Leu Arg Asp 
        355                 360                 365             


Ile Leu Lys Lys Gly Ala Thr Phe Asn Arg Glu Thr Pro Gly Val Pro 
    370                 375                 380                 


Ile Ala Tyr Thr Thr Asn Phe Leu Lys Asp Asn Glu Leu Ala Val Ile 
385                 390                 395                 400 


Lys Asn Asn Ser Glu Tyr Ile Glu Thr Thr Ser Lys Ala Tyr Thr Asp 
                405                 410                 415     


Gly Lys Ile Asn Ile Asp His Ser Gly Gly Tyr Val Ala Gln Phe Asn 
            420                 425                 430         


Ile Ser Trp Asp Glu Val Asn Tyr Asp Leu Glu Thr His Leu Asp Met 
        435                 440                 445             


Leu Arg His Leu Tyr Gln Gly Cys Gln Val Val Gln Gly Asn Leu Glu 
    450                 455                 460                 


Leu Thr Tyr Leu Pro Thr Asn Ala Ser Leu Ser Phe Leu Gln Asp Ile 
465                 470                 475                 480 


Gln Glu Val Gln Gly Tyr Val Leu Ile Ala His Asn Gln Val Arg Gln 
                485                 490                 495     


Val Pro Leu Gln Arg Leu Arg Ile Val Arg Gly Thr Gln Leu Phe Glu 
            500                 505                 510         


Asp Asn Tyr Ala Leu Ala Val Leu Asp Asn Gly Asp Pro Leu Asn Asn 
        515                 520                 525             


Thr Thr Pro Val Thr Gly Ala Ser Pro Gly Gly Leu Arg Glu Leu Gln 
    530                 535                 540                 


Leu Arg Ser Leu Thr Glu Ile Leu Lys Gly Gly Val Leu Ile Gln Arg 
545                 550                 555                 560 


Asn Pro Gln Leu Cys Tyr Gln Asp Thr Ile Leu Trp Lys Asn Ile Gln 
                565                 570                 575     


Glu Phe Ala Gly Cys Lys Lys Ile Phe Gly Ser Leu Ala Phe Leu Pro 
            580                 585                 590         


Glu Ser Phe Asp Gly Asp Pro Ala Ser Asn Thr Ala Pro Leu Gln Pro 
        595                 600                 605             


Glu Gln Leu Gln Val Phe Glu Thr Leu Glu Glu Ile Thr Gly Tyr Leu 
    610                 615                 620                 


Tyr Ile Ser Ala Trp Pro Asp Ser Leu Pro Asp Leu Ser Val Phe Gln 
625                 630                 635                 640 


Asn Leu Gln Val Ile Arg Gly Arg Ile Leu His Asn Gly Ala Tyr Ser 
                645                 650                 655     


Leu Thr Leu Gln Gly Leu Gly Ile Ser Trp Leu Gly Leu Arg Ser Leu 
            660                 665                 670         


Arg Glu Leu Gly Ser Gly Leu Ala Leu Ile His His Asn Thr His Leu 
        675                 680                 685             


Cys Phe Val His Thr Val Pro Trp Asp Gln Leu Phe Arg Asn Pro His 
    690                 695                 700                 


Gln Ala Leu Leu His Thr Ala Asn Arg Pro Glu Asp Glu Cys Val Gly 
705                 710                 715                 720 


Glu Gly Leu Ala Cys His Gln Leu Cys Ala Arg Gly Gln Gln Lys Ile 
                725                 730                 735     


Arg Lys Tyr Thr Met Arg Arg Leu Leu Gln Glu Thr Glu Leu Val Glu 
            740                 745                 750         


Pro Leu Thr Pro Ser Gly Ala Met Pro Asn Gln Ala Gln Met Arg Ile 
        755                 760                 765             


Leu Lys Glu Thr Glu Leu Arg Lys Val Lys Val Leu Gly Ser Gly Ala 
    770                 775                 780                 


Phe Gly Thr Val Tyr Lys Gly Ile Trp Ile Pro Asp Gly Glu Asn Val 
785                 790                 795                 800 


Lys Ile Pro Val Ala Ile Lys Val Leu Arg Glu Asn Thr Ser Pro Lys 
                805                 810                 815     


Ala Asn Lys Glu Ile Leu Asp Glu Ala Tyr Val Met Ala Gly Val Gly 
            820                 825                 830         


Ser Pro Tyr Val Ser Arg Leu Leu Gly Ile Cys Leu Thr Ser Thr Val 
        835                 840                 845             


Gln Leu Val Thr Gln Leu Met Pro Tyr Gly Cys Leu Leu Asp 
    850                 855                 860         


<210>  18
<211>  390
<212>  PRT
<213>  Listeria monocytogenes

<400>  18

Met Arg Ala Met Met Val Val Phe Ile Thr Ala Asn Cys Ile Thr Ile 
1               5                   10                  15      


Asn Pro Asp Ile Ile Phe Ala Ala Thr Asp Ser Glu Asp Ser Ser Leu 
            20                  25                  30          


Asn Thr Asp Glu Trp Glu Glu Glu Lys Thr Glu Glu Gln Pro Ser Glu 
        35                  40                  45              


Val Asn Thr Gly Pro Arg Tyr Glu Thr Ala Arg Glu Val Ser Ser Arg 
    50                  55                  60                  


Asp Ile Lys Glu Leu Glu Lys Ser Asn Lys Val Arg Asn Thr Asn Lys 
65                  70                  75                  80  


Ala Asp Leu Ile Ala Met Leu Lys Glu Lys Ala Glu Lys Gly Pro Asn 
                85                  90                  95      


Ile Asn Asn Asn Asn Ser Glu Gln Thr Glu Asn Ala Ala Ile Asn Glu 
            100                 105                 110         


Glu Ala Ser Gly Ala Asp Arg Pro Ala Ile Gln Val Glu Arg Arg His 
        115                 120                 125             


Pro Gly Leu Pro Ser Asp Ser Ala Ala Glu Ile Lys Lys Arg Arg Lys 
    130                 135                 140                 


Ala Ile Ala Ser Ser Asp Ser Glu Leu Glu Ser Leu Thr Tyr Pro Asp 
145                 150                 155                 160 


Lys Pro Thr Lys Val Asn Lys Lys Lys Val Ala Lys Glu Ser Val Ala 
                165                 170                 175     


Asp Ala Ser Glu Ser Asp Leu Asp Ser Ser Met Gln Ser Ala Asp Glu 
            180                 185                 190         


Ser Ser Pro Gln Pro Leu Lys Ala Asn Gln Gln Pro Phe Phe Pro Lys 
        195                 200                 205             


Val Phe Lys Lys Ile Lys Asp Ala Gly Lys Trp Val Arg Asp Lys Ile 
    210                 215                 220                 


Asp Glu Asn Pro Glu Val Lys Lys Ala Ile Val Asp Lys Ser Ala Gly 
225                 230                 235                 240 


Leu Ile Asp Gln Leu Leu Thr Lys Lys Lys Ser Glu Glu Val Asn Ala 
                245                 250                 255     


Ser Asp Phe Pro Pro Pro Pro Thr Asp Glu Glu Leu Arg Leu Ala Leu 
            260                 265                 270         


Pro Glu Thr Pro Met Leu Leu Gly Phe Asn Ala Pro Ala Thr Ser Glu 
        275                 280                 285             


Pro Ser Ser Phe Glu Phe Pro Pro Pro Pro Thr Asp Glu Glu Leu Arg 
    290                 295                 300                 


Leu Ala Leu Pro Glu Thr Pro Met Leu Leu Gly Phe Asn Ala Pro Ala 
305                 310                 315                 320 


Thr Ser Glu Pro Ser Ser Phe Glu Phe Pro Pro Pro Pro Thr Glu Asp 
                325                 330                 335     


Glu Leu Glu Ile Ile Arg Glu Thr Ala Ser Ser Leu Asp Ser Ser Phe 
            340                 345                 350         


Thr Arg Gly Asp Leu Ala Ser Leu Arg Asn Ala Ile Asn Arg His Ser 
        355                 360                 365             


Gln Asn Phe Ser Asp Phe Pro Pro Ile Pro Thr Glu Glu Glu Leu Asn 
    370                 375                 380                 


Gly Arg Gly Gly Arg Pro 
385                 390 


<210>  19
<211>  1170
<212>  DNA
<213>  Listeria monocytogenes

<400>  19
atgcgtgcga tgatggtggt tttcattact gccaattgca ttacgattaa ccccgacata       60

atatttgcag cgacagatag cgaagattct agtctaaaca cagatgaatg ggaagaagaa      120

aaaacagaag agcaaccaag cgaggtaaat acgggaccaa gatacgaaac tgcacgtgaa      180

gtaagttcac gtgatattaa agaactagaa aaatcgaata aagtgagaaa tacgaacaaa      240

gcagacctaa tagcaatgtt gaaagaaaaa gcagaaaaag gtccaaatat caataataac      300

aacagtgaac aaactgagaa tgcggctata aatgaagagg cttcaggagc cgaccgacca      360

gctatacaag tggagcgtcg tcatccagga ttgccatcgg atagcgcagc ggaaattaaa      420

aaaagaagga aagccatagc atcatcggat agtgagcttg aaagccttac ttatccggat      480

aaaccaacaa aagtaaataa gaaaaaagtg gcgaaagagt cagttgcgga tgcttctgaa      540

agtgacttag attctagcat gcagtcagca gatgagtctt caccacaacc tttaaaagca      600

aaccaacaac catttttccc taaagtattt aaaaaaataa aagatgcggg gaaatgggta      660

cgtgataaaa tcgacgaaaa tcctgaagta aagaaagcga ttgttgataa aagtgcaggg      720

ttaattgacc aattattaac caaaaagaaa agtgaagagg taaatgcttc ggacttcccg      780

ccaccaccta cggatgaaga gttaagactt gctttgccag agacaccaat gcttcttggt      840

tttaatgctc ctgctacatc agaaccgagc tcattcgaat ttccaccacc acctacggat      900

gaagagttaa gacttgcttt gccagagacg ccaatgcttc ttggttttaa tgctcctgct      960

acatcggaac cgagctcgtt cgaatttcca ccgcctccaa cagaagatga actagaaatc     1020

atccgggaaa cagcatcctc gctagattct agttttacaa gaggggattt agctagtttg     1080

agaaatgcta ttaatcgcca tagtcaaaat ttctctgatt tcccaccaat cccaacagaa     1140

gaagagttga acgggagagg cggtagacca                                      1170


<210>  20
<211>  226
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  truncated ActA fused to hly signal peptide

<400>  20

Met Lys Lys Ile Met Leu Val Phe Ile Thr Leu Ile Leu Val Ser Leu 
1               5                   10                  15      


Pro Ile Ala Gln Gln Thr Glu Ala Ser Arg Ala Thr Asp Ser Glu Asp 
            20                  25                  30          


Ser Ser Leu Asn Thr Asp Glu Trp Glu Glu Glu Lys Thr Glu Glu Gln 
        35                  40                  45              


Pro Ser Glu Val Asn Thr Gly Pro Arg Tyr Glu Thr Ala Arg Glu Val 
    50                  55                  60                  


Ser Ser Arg Asp Ile Glu Glu Leu Glu Lys Ser Asn Lys Val Lys Asn 
65                  70                  75                  80  


Thr Asn Lys Ala Asp Leu Ile Ala Met Leu Lys Ala Lys Ala Glu Lys 
                85                  90                  95      


Gly Pro Asn Asn Asn Asn Asn Asn Gly Glu Gln Thr Gly Asn Val Ala 
            100                 105                 110         


Ile Asn Glu Glu Ala Ser Gly Val Asp Arg Pro Thr Leu Gln Val Glu 
        115                 120                 125             


Arg Arg His Pro Gly Leu Ser Ser Asp Ser Ala Ala Glu Ile Lys Lys 
    130                 135                 140                 


Arg Arg Lys Ala Ile Ala Ser Ser Asp Ser Glu Leu Glu Ser Leu Thr 
145                 150                 155                 160 


Tyr Pro Asp Lys Pro Thr Lys Ala Asn Lys Arg Lys Val Ala Lys Glu 
                165                 170                 175     


Ser Val Val Asp Ala Ser Glu Ser Asp Leu Asp Ser Ser Met Gln Ser 
            180                 185                 190         


Ala Asp Glu Ser Thr Pro Gln Pro Leu Lys Ala Asn Gln Lys Pro Phe 
        195                 200                 205             


Phe Pro Lys Val Phe Lys Lys Ile Lys Asp Ala Gly Lys Trp Val Arg 
    210                 215                 220                 


Asp Lys 
225     


<210>  21
<211>  678
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sequence encoding truncated ActA fused to hly signal peptide

<400>  21
atgaaaaaaa taatgctagt ttttattaca cttatattag ttagtctacc aattgcgcaa       60

caaactgaag catctagagc gacagatagc gaagattcca gtctaaacac agatgaatgg      120

gaagaagaaa aaacagaaga gcagccaagc gaggtaaata cgggaccaag atacgaaact      180

gcacgtgaag taagttcacg tgatattgag gaactagaaa aatcgaataa agtgaaaaat      240

acgaacaaag cagacctaat agcaatgttg aaagcaaaag cagagaaagg tccgaataac      300

aataataaca acggtgagca aacaggaaat gtggctataa atgaagaggc ttcaggagtc      360

gaccgaccaa ctctgcaagt ggagcgtcgt catccaggtc tgtcatcgga tagcgcagcg      420

gaaattaaaa aaagaagaaa agccatagcg tcgtcggata gtgagcttga aagccttact      480

tatccagata aaccaacaaa agcaaataag agaaaagtgg cgaaagagtc agttgtggat      540

gcttctgaaa gtgacttaga ttctagcatg cagtcagcag acgagtctac accacaacct      600

ttaaaagcaa atcaaaaacc atttttccct aaagtattta aaaaaataaa agatgcgggg      660

aaatgggtac gtgataaa                                                    678


<210>  22
<211>  14
<212>  PRT
<213>  Listeria monocytogenes

<400>  22

Lys Thr Glu Glu Gln Pro Ser Glu Val Asn Thr Gly Pro Arg 
1               5                   10                  


<210>  23
<211>  28
<212>  PRT
<213>  Listeria monocytogenes

<400>  23

Lys Ala Ser Val Thr Asp Thr Ser Glu Gly Asp Leu Asp Ser Ser Met 
1               5                   10                  15      


Gln Ser Ala Asp Glu Ser Thr Pro Gln Pro Leu Lys 
            20                  25              


<210>  24
<211>  20
<212>  PRT
<213>  Listeria monocytogenes

<400>  24

Lys Asn Glu Glu Val Asn Ala Ser Asp Phe Pro Pro Pro Pro Thr Asp 
1               5                   10                  15      


Glu Glu Leu Arg 
            20  


<210>  25
<211>  33
<212>  PRT
<213>  Listeria monocytogenes

<400>  25

Arg Gly Gly Ile Pro Thr Ser Glu Glu Phe Ser Ser Leu Asn Ser Gly 
1               5                   10                  15      


Asp Phe Thr Asp Asp Glu Asn Ser Glu Thr Thr Glu Glu Glu Ile Asp 
            20                  25                  30          


Arg 
    


<210>  26
<211>  17
<212>  PRT
<213>  Streptococcus pyogenes

<400>  26

Lys Gln Asn Thr Ala Ser Thr Glu Thr Thr Thr Thr Asn Glu Gln Pro 
1               5                   10                  15      


Lys 
    


<210>  27
<211>  17
<212>  PRT
<213>  Streptococcus equisimilis

<400>  27

Lys Gln Asn Thr Ala Asn Thr Glu Thr Thr Thr Thr Asn Glu Gln Pro 
1               5                   10                  15      


Lys 
    


<210>  28
<211>  6523
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  plasmid pAdv142

<400>  28
cggagtgtat actggcttac tatgttggca ctgatgaggg tgtcagtgaa gtgcttcatg       60

tggcaggaga aaaaaggctg caccggtgcg tcagcagaat atgtgataca ggatatattc      120

cgcttcctcg ctcactgact cgctacgctc ggtcgttcga ctgcggcgag cggaaatggc      180

ttacgaacgg ggcggagatt tcctggaaga tgccaggaag atacttaaca gggaagtgag      240

agggccgcgg caaagccgtt tttccatagg ctccgccccc ctgacaagca tcacgaaatc      300

tgacgctcaa atcagtggtg gcgaaacccg acaggactat aaagatacca ggcgtttccc      360

cctggcggct ccctcgtgcg ctctcctgtt cctgcctttc ggtttaccgg tgtcattccg      420

ctgttatggc cgcgtttgtc tcattccacg cctgacactc agttccgggt aggcagttcg      480

ctccaagctg gactgtatgc acgaaccccc cgttcagtcc gaccgctgcg ccttatccgg      540

taactatcgt cttgagtcca acccggaaag acatgcaaaa gcaccactgg cagcagccac      600

tggtaattga tttagaggag ttagtcttga agtcatgcgc cggttaaggc taaactgaaa      660

ggacaagttt tggtgactgc gctcctccaa gccagttacc tcggttcaaa gagttggtag      720

ctcagagaac cttcgaaaaa ccgccctgca aggcggtttt ttcgttttca gagcaagaga      780

ttacgcgcag accaaaacga tctcaagaag atcatcttat taatcagata aaatatttct      840

agccctcctt tgattagtat attcctatct taaagttact tttatgtgga ggcattaaca      900

tttgttaatg acgtcaaaag gatagcaaga ctagaataaa gctataaagc aagcatataa      960

tattgcgttt catctttaga agcgaatttc gccaatatta taattatcaa aagagagggg     1020

tggcaaacgg tatttggcat tattaggtta aaaaatgtag aaggagagtg aaacccatga     1080

aaaaaataat gctagttttt attacactta tattagttag tctaccaatt gcgcaacaaa     1140

ctgaagcaaa ggatgcatct gcattcaata aagaaaattc aatttcatcc atggcaccac     1200

cagcatctcc gcctgcaagt cctaagacgc caatcgaaaa gaaacacgcg gatgaaatcg     1260

ataagtatat acaaggattg gattacaata aaaacaatgt attagtatac cacggagatg     1320

cagtgacaaa tgtgccgcca agaaaaggtt acaaagatgg aaatgaatat attgttgtgg     1380

agaaaaagaa gaaatccatc aatcaaaata atgcagacat tcaagttgtg aatgcaattt     1440

cgagcctaac ctatccaggt gctctcgtaa aagcgaattc ggaattagta gaaaatcaac     1500

cagatgttct ccctgtaaaa cgtgattcat taacactcag cattgatttg ccaggtatga     1560

ctaatcaaga caataaaata gttgtaaaaa atgccactaa atcaaacgtt aacaacgcag     1620

taaatacatt agtggaaaga tggaatgaaa aatatgctca agcttatcca aatgtaagtg     1680

caaaaattga ttatgatgac gaaatggctt acagtgaatc acaattaatt gcgaaatttg     1740

gtacagcatt taaagctgta aataatagct tgaatgtaaa cttcggcgca atcagtgaag     1800

ggaaaatgca agaagaagtc attagtttta aacaaattta ctataacgtg aatgttaatg     1860

aacctacaag accttccaga tttttcggca aagctgttac taaagagcag ttgcaagcgc     1920

ttggagtgaa tgcagaaaat cctcctgcat atatctcaag tgtggcgtat ggccgtcaag     1980

tttatttgaa attatcaact aattcccata gtactaaagt aaaagctgct tttgatgctg     2040

ccgtaagcgg aaaatctgtc tcaggtgatg tagaactaac aaatatcatc aaaaattctt     2100

ccttcaaagc cgtaatttac ggaggttccg caaaagatga agttcaaatc atcgacggca     2160

acctcggaga cttacgcgat attttgaaaa aaggcgctac ttttaatcga gaaacaccag     2220

gagttcccat tgcttataca acaaacttcc taaaagacaa tgaattagct gttattaaaa     2280

acaactcaga atatattgaa acaacttcaa aagcttatac agatggaaaa attaacatcg     2340

atcactctgg aggatacgtt gctcaattca acatttcttg ggatgaagta aattatgatc     2400

tcgagattgt gggaggctgg gagtgcgaga agcattccca accctggcag gtgcttgtgg     2460

cctctcgtgg cagggcagtc tgcggcggtg ttctggtgca cccccagtgg gtcctcacag     2520

ctgcccactg catcaggaac aaaagcgtga tcttgctggg tcggcacagc ctgtttcatc     2580

ctgaagacac aggccaggta tttcaggtca gccacagctt cccacacccg ctctacgata     2640

tgagcctcct gaagaatcga ttcctcaggc caggtgatga ctccagccac gacctcatgc     2700

tgctccgcct gtcagagcct gccgagctca cggatgctgt gaaggtcatg gacctgccca     2760

cccaggagcc agcactgggg accacctgct acgcctcagg ctggggcagc attgaaccag     2820

aggagttctt gaccccaaag aaacttcagt gtgtggacct ccatgttatt tccaatgacg     2880

tgtgtgcgca agttcaccct cagaaggtga ccaagttcat gctgtgtgct ggacgctgga     2940

cagggggcaa aagcacctgc tcgggtgatt ctgggggccc acttgtctgt tatggtgtgc     3000

ttcaaggtat cacgtcatgg ggcagtgaac catgtgccct gcccgaaagg ccttccctgt     3060

acaccaaggt ggtgcattac cggaagtgga tcaaggacac catcgtggcc aacccctaac     3120

ccgggccact aactcaacgc tagtagtgga tttaatccca aatgagccaa cagaaccaga     3180

accagaaaca gaacaagtaa cattggagtt agaaatggaa gaagaaaaaa gcaatgattt     3240

cgtgtgaata atgcacgaaa tcattgctta tttttttaaa aagcgatata ctagatataa     3300

cgaaacaacg aactgaataa agaatacaaa aaaagagcca cgaccagtta aagcctgaga     3360

aactttaact gcgagcctta attgattacc accaatcaat taaagaagtc gagacccaaa     3420

atttggtaaa gtatttaatt actttattaa tcagatactt aaatatctgt aaacccatta     3480

tatcgggttt ttgaggggat ttcaagtctt taagaagata ccaggcaatc aattaagaaa     3540

aacttagttg attgcctttt ttgttgtgat tcaactttga tcgtagcttc taactaatta     3600

attttcgtaa gaaaggagaa cagctgaatg aatatccctt ttgttgtaga aactgtgctt     3660

catgacggct tgttaaagta caaatttaaa aatagtaaaa ttcgctcaat cactaccaag     3720

ccaggtaaaa gtaaaggggc tatttttgcg tatcgctcaa aaaaaagcat gattggcgga     3780

cgtggcgttg ttctgacttc cgaagaagcg attcacgaaa atcaagatac atttacgcat     3840

tggacaccaa acgtttatcg ttatggtacg tatgcagacg aaaaccgttc atacactaaa     3900

ggacattctg aaaacaattt aagacaaatc aataccttct ttattgattt tgatattcac     3960

acggaaaaag aaactatttc agcaagcgat attttaacaa cagctattga tttaggtttt     4020

atgcctacgt taattatcaa atctgataaa ggttatcaag catattttgt tttagaaacg     4080

ccagtctatg tgacttcaaa atcagaattt aaatctgtca aagcagccaa aataatctcg     4140

caaaatatcc gagaatattt tggaaagtct ttgccagttg atctaacgtg caatcatttt     4200

gggattgctc gtataccaag aacggacaat gtagaatttt ttgatcccaa ttaccgttat     4260

tctttcaaag aatggcaaga ttggtctttc aaacaaacag ataataaggg ctttactcgt     4320

tcaagtctaa cggttttaag cggtacagaa ggcaaaaaac aagtagatga accctggttt     4380

aatctcttat tgcacgaaac gaaattttca ggagaaaagg gtttagtagg gcgcaatagc     4440

gttatgttta ccctctcttt agcctacttt agttcaggct attcaatcga aacgtgcgaa     4500

tataatatgt ttgagtttaa taatcgatta gatcaaccct tagaagaaaa agaagtaatc     4560

aaaattgtta gaagtgccta ttcagaaaac tatcaagggg ctaataggga atacattacc     4620

attctttgca aagcttgggt atcaagtgat ttaaccagta aagatttatt tgtccgtcaa     4680

gggtggttta aattcaagaa aaaaagaagc gaacgtcaac gtgttcattt gtcagaatgg     4740

aaagaagatt taatggctta tattagcgaa aaaagcgatg tatacaagcc ttatttagcg     4800

acgaccaaaa aagagattag agaagtgcta ggcattcctg aacggacatt agataaattg     4860

ctgaaggtac tgaaggcgaa tcaggaaatt ttctttaaga ttaaaccagg aagaaatggt     4920

ggcattcaac ttgctagtgt taaatcattg ttgctatcga tcattaaatt aaaaaaagaa     4980

gaacgagaaa gctatataaa ggcgctgaca gcttcgttta atttagaacg tacatttatt     5040

caagaaactc taaacaaatt ggcagaacgc cccaaaacgg acccacaact cgatttgttt     5100

agctacgata caggctgaaa ataaaacccg cactatgcca ttacatttat atctatgata     5160

cgtgtttgtt tttctttgct ggctagctta attgcttata tttacctgca ataaaggatt     5220

tcttacttcc attatactcc cattttccaa aaacatacgg ggaacacggg aacttattgt     5280

acaggccacc tcatagttaa tggtttcgag ccttcctgca atctcatcca tggaaatata     5340

ttcatccccc tgccggccta ttaatgtgac ttttgtgccc ggcggatatt cctgatccag     5400

ctccaccata aattggtcca tgcaaattcg gccggcaatt ttcaggcgtt ttcccttcac     5460

aaggatgtcg gtccctttca attttcggag ccagccgtcc gcatagccta caggcaccgt     5520

cccgatccat gtgtcttttt ccgctgtgta ctcggctccg tagctgacgc tctcgccttt     5580

tctgatcagt ttgacatgtg acagtgtcga atgcagggta aatgccggac gcagctgaaa     5640

cggtatctcg tccgacatgt cagcagacgg gcgaaggcca tacatgccga tgccgaatct     5700

gactgcatta aaaaagcctt ttttcagccg gagtccagcg gcgctgttcg cgcagtggac     5760

cattagattc tttaacggca gcggagcaat cagctcttta aagcgctcaa actgcattaa     5820

gaaatagcct ctttcttttt catccgctgt cgcaaaatgg gtaaataccc ctttgcactt     5880

taaacgaggg ttgcggtcaa gaattgccat cacgttctga acttcttcct ctgtttttac     5940

accaagtctg ttcatccccg tatcgacctt cagatgaaaa tgaagagaac cttttttcgt     6000

gtggcgggct gcctcctgaa gccattcaac agaataacct gttaaggtca cgtcatactc     6060

agcagcgatt gccacatact ccgggggaac cgcgccaagc accaatatag gcgccttcaa     6120

tccctttttg cgcagtgaaa tcgcttcatc caaaatggcc acggccaagc atgaagcacc     6180

tgcgtcaaga gcagcctttg ctgtttctgc atcaccatgc ccgtaggcgt ttgctttcac     6240

aactgccatc aagtggacat gttcaccgat atgttttttc atattgctga cattttcctt     6300

tatcgcggac aagtcaattt ccgcccacgt atctctgtaa aaaggttttg tgctcatgga     6360

aaactcctct cttttttcag aaaatcccag tacgtaatta agtatttgag aattaatttt     6420

atattgatta atactaagtt tacccagttt tcacctaaaa aacaaatgat gagataatag     6480

ctccaaaggc taaagaggac tataccaact atttgttaat taa                       6523


<210>  29
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  29
cggaattcgg atccgcgcca aatcattggt tgattg                                 36


<210>  30
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  30
gcgagtcgac gtcggggtta atcgtaatgc aattggc                                37


<210>  31
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  31
gcgagtcgac ccatacgacg ttaattcttg caatg                                  35


<210>  32
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  32
gatactgcag ggatccttcc cttctcggta atcagtcac                              39


<210>  33
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  33
tgggatggcc aagaaattc                                                    19


<210>  34
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  34
ctaccatgtc ttccgttgct tg                                                22


<210>  35
<211>  7075
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pAdv164 sequence

<400>  35
cggagtgtat actggcttac tatgttggca ctgatgaggg tgtcagtgaa gtgcttcatg       60

tggcaggaga aaaaaggctg caccggtgcg tcagcagaat atgtgataca ggatatattc      120

cgcttcctcg ctcactgact cgctacgctc ggtcgttcga ctgcggcgag cggaaatggc      180

ttacgaacgg ggcggagatt tcctggaaga tgccaggaag atacttaaca gggaagtgag      240

agggccgcgg caaagccgtt tttccatagg ctccgccccc ctgacaagca tcacgaaatc      300

tgacgctcaa atcagtggtg gcgaaacccg acaggactat aaagatacca ggcgtttccc      360

cctggcggct ccctcgtgcg ctctcctgtt cctgcctttc ggtttaccgg tgtcattccg      420

ctgttatggc cgcgtttgtc tcattccacg cctgacactc agttccgggt aggcagttcg      480

ctccaagctg gactgtatgc acgaaccccc cgttcagtcc gaccgctgcg ccttatccgg      540

taactatcgt cttgagtcca acccggaaag acatgcaaaa gcaccactgg cagcagccac      600

tggtaattga tttagaggag ttagtcttga agtcatgcgc cggttaaggc taaactgaaa      660

ggacaagttt tggtgactgc gctcctccaa gccagttacc tcggttcaaa gagttggtag      720

ctcagagaac cttcgaaaaa ccgccctgca aggcggtttt ttcgttttca gagcaagaga      780

ttacgcgcag accaaaacga tctcaagaag atcatcttat taatcagata aaatatttct      840

agccctcctt tgattagtat attcctatct taaagttact tttatgtgga ggcattaaca      900

tttgttaatg acgtcaaaag gatagcaaga ctagaataaa gctataaagc aagcatataa      960

tattgcgttt catctttaga agcgaatttc gccaatatta taattatcaa aagagagggg     1020

tggcaaacgg tatttggcat tattaggtta aaaaatgtag aaggagagtg aaacccatga     1080

aaaaaataat gctagttttt attacactta tattagttag tctaccaatt gcgcaacaaa     1140

ctgaagcaaa ggatgcatct gcattcaata aagaaaattc aatttcatcc atggcaccac     1200

cagcatctcc gcctgcaagt cctaagacgc caatcgaaaa gaaacacgcg gatgaaatcg     1260

ataagtatat acaaggattg gattacaata aaaacaatgt attagtatac cacggagatg     1320

cagtgacaaa tgtgccgcca agaaaaggtt acaaagatgg aaatgaatat attgttgtgg     1380

agaaaaagaa gaaatccatc aatcaaaata atgcagacat tcaagttgtg aatgcaattt     1440

cgagcctaac ctatccaggt gctctcgtaa aagcgaattc ggaattagta gaaaatcaac     1500

cagatgttct ccctgtaaaa cgtgattcat taacactcag cattgatttg ccaggtatga     1560

ctaatcaaga caataaaata gttgtaaaaa atgccactaa atcaaacgtt aacaacgcag     1620

taaatacatt agtggaaaga tggaatgaaa aatatgctca agcttatcca aatgtaagtg     1680

caaaaattga ttatgatgac gaaatggctt acagtgaatc acaattaatt gcgaaatttg     1740

gtacagcatt taaagctgta aataatagct tgaatgtaaa cttcggcgca atcagtgaag     1800

ggaaaatgca agaagaagtc attagtttta aacaaattta ctataacgtg aatgttaatg     1860

aacctacaag accttccaga tttttcggca aagctgttac taaagagcag ttgcaagcgc     1920

ttggagtgaa tgcagaaaat cctcctgcat atatctcaag tgtggcgtat ggccgtcaag     1980

tttatttgaa attatcaact aattcccata gtactaaagt aaaagctgct tttgatgctg     2040

ccgtaagcgg aaaatctgtc tcaggtgatg tagaactaac aaatatcatc aaaaattctt     2100

ccttcaaagc cgtaatttac ggaggttccg caaaagatga agttcaaatc atcgacggca     2160

acctcggaga cttacgcgat attttgaaaa aaggcgctac ttttaatcga gaaacaccag     2220

gagttcccat tgcttataca acaaacttcc taaaagacaa tgaattagct gttattaaaa     2280

acaactcaga atatattgaa acaacttcaa aagcttatac agatggaaaa attaacatcg     2340

atcactctgg aggatacgtt gctcaattca acatttcttg ggatgaagta aattatgatc     2400

tcgagaccca cctggacatg ctccgccacc tctaccaggg ctgccaggtg gtgcagggaa     2460

acctggaact cacctacctg cccaccaatg ccagcctgtc cttcctgcag gatatccagg     2520

aggtgcaggg ctacgtgctc atcgctcaca accaagtgag gcaggtccca ctgcagaggc     2580

tgcggattgt gcgaggcacc cagctctttg aggacaacta tgccctggcc gtgctagaca     2640

atggagaccc gctgaacaat accacccctg tcacaggggc ctccccagga ggcctgcggg     2700

agctgcagct tcgaagcctc acagagatct tgaaaggagg ggtcttgatc cagcggaacc     2760

cccagctctg ctaccaggac acgattttgt ggaagaatat ccaggagttt gctggctgca     2820

agaagatctt tgggagcctg gcatttctgc cggagagctt tgatggggac ccagcctcca     2880

acactgcccc gctccagcca gagcagctcc aagtgtttga gactctggaa gagatcacag     2940

gttacctata catctcagca tggccggaca gcctgcctga cctcagcgtc ttccagaacc     3000

tgcaagtaat ccggggacga attctgcaca atggcgccta ctcgctgacc ctgcaagggc     3060

tgggcatcag ctggctgggg ctgcgctcac tgagggaact gggcagtgga ctggccctca     3120

tccaccataa cacccacctc tgcttcgtgc acacggtgcc ctgggaccag ctctttcgga     3180

acccgcacca agctctgctc cacactgcca accggccaga ggacgagtgt gtgggcgagg     3240

gcctggcctg ccaccagctg tgcgcccgag ggcagcagaa gatccggaag tacacgatgc     3300

ggagactgct gcaggaaacg gagctggtgg agccgctgac acctagcgga gcgatgccca     3360

accaggcgca gatgcggatc ctgaaagaga cggagctgag gaaggtgaag gtgcttggat     3420

ctggcgcttt tggcacagtc tacaagggca tctggatccc tgatggggag aatgtgaaaa     3480

ttccagtggc catcaaagtg ttgagggaaa acacatcccc caaagccaac aaagaaatct     3540

tagacgaagc atacgtgatg gctggtgtgg gctccccata tgtctcccgc cttctgggca     3600

tctgcctgac atccacggtg cagctggtga cacagcttat gccctatggc tgcctcttag     3660

actaatctag acccgggcca ctaactcaac gctagtagtg gatttaatcc caaatgagcc     3720

aacagaacca gaaccagaaa cagaacaagt aacattggag ttagaaatgg aagaagaaaa     3780

aagcaatgat ttcgtgtgaa taatgcacga aatcattgct tattttttta aaaagcgata     3840

tactagatat aacgaaacaa cgaactgaat aaagaataca aaaaaagagc cacgaccagt     3900

taaagcctga gaaactttaa ctgcgagcct taattgatta ccaccaatca attaaagaag     3960

tcgagaccca aaatttggta aagtatttaa ttactttatt aatcagatac ttaaatatct     4020

gtaaacccat tatatcgggt ttttgagggg atttcaagtc tttaagaaga taccaggcaa     4080

tcaattaaga aaaacttagt tgattgcctt ttttgttgtg attcaacttt gatcgtagct     4140

tctaactaat taattttcgt aagaaaggag aacagctgaa tgaatatccc ttttgttgta     4200

gaaactgtgc ttcatgacgg cttgttaaag tacaaattta aaaatagtaa aattcgctca     4260

atcactacca agccaggtaa aagtaaaggg gctatttttg cgtatcgctc aaaaaaaagc     4320

atgattggcg gacgtggcgt tgttctgact tccgaagaag cgattcacga aaatcaagat     4380

acatttacgc attggacacc aaacgtttat cgttatggta cgtatgcaga cgaaaaccgt     4440

tcatacacta aaggacattc tgaaaacaat ttaagacaaa tcaatacctt ctttattgat     4500

tttgatattc acacggaaaa agaaactatt tcagcaagcg atattttaac aacagctatt     4560

gatttaggtt ttatgcctac gttaattatc aaatctgata aaggttatca agcatatttt     4620

gttttagaaa cgccagtcta tgtgacttca aaatcagaat ttaaatctgt caaagcagcc     4680

aaaataatct cgcaaaatat ccgagaatat tttggaaagt ctttgccagt tgatctaacg     4740

tgcaatcatt ttgggattgc tcgtatacca agaacggaca atgtagaatt ttttgatccc     4800

aattaccgtt attctttcaa agaatggcaa gattggtctt tcaaacaaac agataataag     4860

ggctttactc gttcaagtct aacggtttta agcggtacag aaggcaaaaa acaagtagat     4920

gaaccctggt ttaatctctt attgcacgaa acgaaatttt caggagaaaa gggtttagta     4980

gggcgcaata gcgttatgtt taccctctct ttagcctact ttagttcagg ctattcaatc     5040

gaaacgtgcg aatataatat gtttgagttt aataatcgat tagatcaacc cttagaagaa     5100

aaagaagtaa tcaaaattgt tagaagtgcc tattcagaaa actatcaagg ggctaatagg     5160

gaatacatta ccattctttg caaagcttgg gtatcaagtg atttaaccag taaagattta     5220

tttgtccgtc aagggtggtt taaattcaag aaaaaaagaa gcgaacgtca acgtgttcat     5280

ttgtcagaat ggaaagaaga tttaatggct tatattagcg aaaaaagcga tgtatacaag     5340

ccttatttag cgacgaccaa aaaagagatt agagaagtgc taggcattcc tgaacggaca     5400

ttagataaat tgctgaaggt actgaaggcg aatcaggaaa ttttctttaa gattaaacca     5460

ggaagaaatg gtggcattca acttgctagt gttaaatcat tgttgctatc gatcattaaa     5520

ttaaaaaaag aagaacgaga aagctatata aaggcgctga cagcttcgtt taatttagaa     5580

cgtacattta ttcaagaaac tctaaacaaa ttggcagaac gccccaaaac ggacccacaa     5640

ctcgatttgt ttagctacga tacaggctga aaataaaacc cgcactatgc cattacattt     5700

atatctatga tacgtgtttg tttttctttg ctggctagct taattgctta tatttacctg     5760

caataaagga tttcttactt ccattatact cccattttcc aaaaacatac ggggaacacg     5820

ggaacttatt gtacaggcca cctcatagtt aatggtttcg agccttcctg caatctcatc     5880

catggaaata tattcatccc cctgccggcc tattaatgtg acttttgtgc ccggcggata     5940

ttcctgatcc agctccacca taaattggtc catgcaaatt cggccggcaa ttttcaggcg     6000

ttttcccttc acaaggatgt cggtcccttt caattttcgg agccagccgt ccgcatagcc     6060

tacaggcacc gtcccgatcc atgtgtcttt ttccgctgtg tactcggctc cgtagctgac     6120

gctctcgcct tttctgatca gtttgacatg tgacagtgtc gaatgcaggg taaatgccgg     6180

acgcagctga aacggtatct cgtccgacat gtcagcagac gggcgaaggc catacatgcc     6240

gatgccgaat ctgactgcat taaaaaagcc ttttttcagc cggagtccag cggcgctgtt     6300

cgcgcagtgg accattagat tctttaacgg cagcggagca atcagctctt taaagcgctc     6360

aaactgcatt aagaaatagc ctctttcttt ttcatccgct gtcgcaaaat gggtaaatac     6420

ccctttgcac tttaaacgag ggttgcggtc aagaattgcc atcacgttct gaacttcttc     6480

ctctgttttt acaccaagtc tgttcatccc cgtatcgacc ttcagatgaa aatgaagaga     6540

accttttttc gtgtggcggg ctgcctcctg aagccattca acagaataac ctgttaaggt     6600

cacgtcatac tcagcagcga ttgccacata ctccggggga accgcgccaa gcaccaatat     6660

aggcgccttc aatccctttt tgcgcagtga aatcgcttca tccaaaatgg ccacggccaa     6720

gcatgaagca cctgcgtcaa gagcagcctt tgctgtttct gcatcaccat gcccgtaggc     6780

gtttgctttc acaactgcca tcaagtggac atgttcaccg atatgttttt tcatattgct     6840

gacattttcc tttatcgcgg acaagtcaat ttccgcccac gtatctctgt aaaaaggttt     6900

tgtgctcatg gaaaactcct ctcttttttc agaaaatccc agtacgtaat taagtatttg     6960

agaattaatt ttatattgat taatactaag tttacccagt tttcacctaa aaaacaaatg     7020

atgagataat agctccaaag gctaaagagg actataccaa ctatttgtta attaa          7075


<210>  36
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mapped HLA-A2 restricted extracellular epitope

<400>  36

His Leu Tyr Gln Gly Cys Gln Val Val 
1               5                   


<210>  37
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mapped HLA-A2 restricted extracellular epitope

<400>  37

Lys Ile Phe Gly Ser Leu Ala Phe Leu 
1               5                   


<210>  38
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mapped HLA-A2 restricted intracellular epitope

<400>  38

Arg Leu Leu Gln Glu Thr Glu Leu Val 
1               5                   


