                         SEQUENCE LISTING

<110>  Institut de Recerca de la SIDA-Caixa
       Carrillo Molina, Jorge
       Clotet Sala, Bonaventura
       Blanco Arbues, Julian M.
 
<120>  HIV antibody derivatives with dual antiviral and immunomodulatory
        activity

<130>  P1514US

<140>  US 14/948,274
<141>  2015-11-21

<160>  42    

<170>  PatentIn version 3.5

<210>  1
<211>  100
<212>  PRT
<213>  Homo sapiens


<220>
<221>  PEPTIDE
<222>  (1)..(100)
<223>  D1 domain of human CD4 receptor (aa)

<400>  1

Lys Lys Val Val Leu Gly Lys Lys Gly Asp Thr Val Glu Leu Thr Cys 
1               5                   10                  15      


Thr Ala Ser Gln Lys Lys Ser Ile Gln Phe His Trp Lys Asn Ser Asn 
            20                  25                  30          


Gln Ile Lys Ile Leu Gly Asn Gln Gly Ser Phe Leu Thr Lys Gly Pro 
        35                  40                  45              


Ser Lys Leu Asn Asp Arg Ala Asp Ser Arg Arg Ser Leu Trp Asp Gln 
    50                  55                  60                  


Gly Asn Phe Pro Leu Ile Ile Lys Asn Leu Lys Ile Glu Asp Ser Asp 
65                  70                  75                  80  


Thr Tyr Ile Cys Glu Val Glu Asp Gln Lys Glu Glu Val Gln Leu Leu 
                85                  90                  95      


Val Phe Gly Leu 
            100 


<210>  2
<211>  78
<212>  PRT
<213>  Homo sapiens


<220>
<221>  PEPTIDE
<222>  (1)..(78)
<223>  D2 domain of human CD4 receptor (aa)

<400>  2

Thr Ala Asn Ser Asp Thr His Leu Leu Gln Gly Gln Ser Leu Thr Leu 
1               5                   10                  15      


Thr Leu Glu Ser Pro Pro Gly Ser Ser Pro Ser Val Gln Cys Arg Ser 
            20                  25                  30          


Pro Arg Gly Lys Asn Ile Gln Gly Gly Lys Thr Leu Ser Val Ser Gln 
        35                  40                  45              


Leu Glu Leu Gln Asp Ser Gly Thr Trp Thr Cys Thr Val Leu Gln Asn 
    50                  55                  60                  


Gln Lys Lys Val Glu Phe Lys Ile Asp Ile Val Val Leu Ala 
65                  70                  75              


<210>  3
<211>  232
<212>  PRT
<213>  Homo sapiens


<220>
<221>  PEPTIDE
<222>  (1)..(232)
<223>  Fc portion of the human IgG1 (aa)

<400>  3

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230         


<210>  4
<211>  232
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fc portion of the human IgG1 with G236A, S293D, A330L and I332E 
       point mutations (aa)


<220>
<221>  PEPTIDE
<222>  (1)..(232)
<223>  Fc portion of the human IgG1 with G236A, S239D, A330L and I332E 
       point mutations (aa)

<400>  4

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Ala Gly Pro Asp Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Leu Pro Glu Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230         


<210>  5
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker polypeptide (aa)


<220>
<221>  PEPTIDE
<222>  (1)..(5)
<223>  Linker polypeptide (aa)

<400>  5

Gly Gly Gly Gly Ser 
1               5   


<210>  6
<211>  29
<212>  PRT
<213>  Homo sapiens


<220>
<221>  PEPTIDE
<222>  (1)..(29)
<223>  N-terminal region of the human CCR5 receptor (aa)

<400>  6

Met Asp Tyr Gln Val Ser Ser Pro Ile Tyr Asp Ile Asn Tyr Tyr Thr 
1               5                   10                  15      


Ser Glu Pro Cys Gln Lys Ile Asn Val Lys Gln Ile Ala 
            20                  25                  


<210>  7
<211>  36
<212>  PRT
<213>  Human immunodeficiency virus


<220>
<221>  PEPTIDE
<222>  (1)..(36)
<223>  T-20 polypeptide (aa)

<400>  7

Tyr Thr Ser Leu Ile His Ser Leu Ile Glu Glu Ser Gln Asn Gln Gln 
1               5                   10                  15      


Glu Lys Asn Glu Gln Glu Leu Leu Glu Leu Asp Lys Trp Ala Ser Leu 
            20                  25                  30          


Trp Asn Trp Phe 
        35      


<210>  8
<211>  39
<212>  PRT
<213>  Human immunodeficiency virus


<220>
<221>  PEPTIDE
<222>  (1)..(39)
<223>  T-1249 polypeptide (aa)

<400>  8

Trp Gln Glu Trp Glu Gln Lys Ile Thr Ala Leu Leu Glu Gln Ala Gln 
1               5                   10                  15      


Ile Gln Gln Glu Lys Asn Glu Tyr Glu Leu Gln Lys Leu Asp Lys Trp 
            20                  25                  30          


Ala Ser Leu Trp Glu Trp Phe 
        35                  


<210>  9
<211>  34
<212>  PRT
<213>  Human immunodeficiency virus


<220>
<221>  PEPTIDE
<222>  (1)..(34)
<223>  C34 polypeptide (aa)

<400>  9

Trp Met Glu Trp Asp Arg Glu Ile Asn Asn Tyr Thr Ser Leu Ile His 
1               5                   10                  15      


Ser Leu Ile Glu Glu Ser Gln Asn Gln Gln Glu Lys Asn Glu Gln Glu 
            20                  25                  30          


Leu Leu 
        


<210>  10
<211>  38
<212>  PRT
<213>  Human immunodeficiency virus


<220>
<221>  PEPTIDE
<222>  (1)..(38)
<223>  T-2635 polypeptide (aa)

<400>  10

Thr Thr Trp Glu Ala Trp Asp Arg Ala Ile Ala Glu Tyr Ala Ala Arg 
1               5                   10                  15      


Ile Glu Ala Leu Ile Arg Ala Ala Gln Glu Gln Gln Glu Lys Asn Glu 
            20                  25                  30          


Ala Ala Leu Arg Glu Leu 
        35              


<210>  11
<211>  404
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein MOLECULE-0 (aa)


<220>
<221>  PEPTIDE
<222>  (1)..(404)
<223>  Fusion protein MOLECULE-0 (aa)

<400>  11

Lys Lys Gly Asp Thr Val Glu Leu Thr Cys Thr Ala Ser Gln Lys Lys 
1               5                   10                  15      


Ser Ile Gln Phe His Trp Lys Asn Ser Asn Gln Ile Lys Ile Leu Gly 
            20                  25                  30          


Asn Gln Gly Ser Phe Leu Thr Lys Gly Pro Ser Lys Leu Asn Asp Arg 
        35                  40                  45              


Ala Asp Ser Arg Arg Ser Leu Trp Asp Gln Gly Asn Phe Pro Leu Ile 
    50                  55                  60                  


Ile Lys Asn Leu Lys Ile Glu Asp Ser Asp Thr Tyr Ile Cys Glu Val 
65                  70                  75                  80  


Glu Asp Gln Lys Glu Glu Val Gln Leu Leu Val Phe Gly Leu Thr Ala 
                85                  90                  95      


Asn Ser Asp Thr His Leu Leu Gln Gly Gln Ser Leu Thr Leu Thr Leu 
            100                 105                 110         


Glu Ser Pro Pro Gly Ser Ser Pro Ser Val Gln Cys Arg Ser Pro Arg 
        115                 120                 125             


Gly Lys Asn Ile Gln Gly Gly Lys Thr Leu Ser Val Ser Gln Leu Glu 
    130                 135                 140                 


Leu Gln Asp Ser Gly Thr Trp Thr Cys Thr Val Leu Gln Asn Gln Lys 
145                 150                 155                 160 


Lys Val Glu Phe Lys Ile Asp Ile Val Val Leu Ala Glu Pro Lys Ser 
                165                 170                 175     


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
            180                 185                 190         


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
        195                 200                 205             


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
    210                 215                 220                 


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
225                 230                 235                 240 


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
                245                 250                 255     


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
            260                 265                 270         


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
        275                 280                 285             


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
    290                 295                 300                 


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
305                 310                 315                 320 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
                325                 330                 335     


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
            340                 345                 350         


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
        355                 360                 365             


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
    370                 375                 380                 


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
385                 390                 395                 400 


Ser Pro Gly Lys 
                


<210>  12
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein MOLECULE-1 (aa)


<220>
<221>  PEPTIDE
<222>  (1)..(457)
<223>  Fusion protein MOLECULE-1 (aa)

<400>  12

Met Pro Met Gly Ser Leu Gln Pro Leu Ala Thr Leu Tyr Leu Leu Gly 
1               5                   10                  15      


Met Leu Val Ala Ser Val Leu Ala Lys Lys Val Val Leu Gly Lys Lys 
            20                  25                  30          


Gly Asp Thr Val Glu Leu Thr Cys Thr Ala Ser Gln Lys Lys Ser Ile 
        35                  40                  45              


Gln Phe His Trp Lys Asn Ser Asn Gln Ile Lys Ile Leu Gly Asn Gln 
    50                  55                  60                  


Gly Ser Phe Leu Thr Lys Gly Pro Ser Lys Leu Asn Asp Arg Ala Asp 
65                  70                  75                  80  


Ser Arg Arg Ser Leu Trp Asp Gln Gly Asn Phe Pro Leu Ile Ile Lys 
                85                  90                  95      


Asn Leu Lys Ile Glu Asp Ser Asp Thr Tyr Ile Cys Glu Val Glu Asp 
            100                 105                 110         


Gln Lys Glu Glu Val Gln Leu Leu Val Phe Gly Leu Thr Ala Asn Ser 
        115                 120                 125             


Asp Thr His Leu Leu Gln Gly Gln Ser Leu Thr Leu Thr Leu Glu Ser 
    130                 135                 140                 


Pro Pro Gly Ser Ser Pro Ser Val Gln Cys Arg Ser Pro Arg Gly Lys 
145                 150                 155                 160 


Asn Ile Gln Gly Gly Lys Thr Leu Ser Val Ser Gln Leu Glu Leu Gln 
                165                 170                 175     


Asp Ser Gly Thr Trp Thr Cys Thr Val Leu Gln Asn Gln Lys Lys Val 
            180                 185                 190         


Glu Phe Lys Ile Asp Ile Val Val Leu Ala Ala Ala Asp Pro Glu Pro 
        195                 200                 205             


Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
    210                 215                 220                 


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
225                 230                 235                 240 


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
                245                 250                 255     


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
            260                 265                 270         


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
        275                 280                 285             


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
    290                 295                 300                 


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
305                 310                 315                 320 


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
                325                 330                 335     


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
            340                 345                 350         


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
        355                 360                 365             


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
    370                 375                 380                 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
385                 390                 395                 400 


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
                405                 410                 415     


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
            420                 425                 430         


Ser Leu Ser Pro Gly Lys Gly Gly Gly Gly Gly Asp Tyr Ala Asp Tyr 
        435                 440                 445             


Asp Gly Gly Tyr Tyr Tyr Asp Met Asp 
    450                 455         


<210>  13
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein MOLECULE-2 (aa)


<220>
<221>  PEPTIDE
<222>  (1)..(457)
<223>  Fusion protein MOLECULE-2 (aa)

<400>  13

Met Pro Met Gly Ser Leu Gln Pro Leu Ala Thr Leu Tyr Leu Leu Gly 
1               5                   10                  15      


Met Leu Val Ala Ser Val Leu Ala Lys Lys Val Val Leu Gly Lys Lys 
            20                  25                  30          


Gly Asp Thr Val Glu Leu Thr Cys Thr Ala Ser Gln Lys Lys Ser Ile 
        35                  40                  45              


Gln Phe His Trp Lys Asn Ser Asn Gln Ile Lys Ile Leu Gly Asn Gln 
    50                  55                  60                  


Gly Ser Phe Leu Thr Lys Gly Pro Ser Lys Leu Asn Asp Arg Ala Asp 
65                  70                  75                  80  


Ser Arg Arg Ser Leu Trp Asp Gln Gly Asn Phe Pro Leu Ile Ile Lys 
                85                  90                  95      


Asn Leu Lys Ile Glu Asp Ser Asp Thr Tyr Ile Cys Glu Val Glu Asp 
            100                 105                 110         


Gln Lys Glu Glu Val Gln Leu Leu Val Phe Gly Leu Thr Ala Asn Ser 
        115                 120                 125             


Asp Thr His Leu Leu Gln Gly Gln Ser Leu Thr Leu Thr Leu Glu Ser 
    130                 135                 140                 


Pro Pro Gly Ser Ser Pro Ser Val Gln Cys Arg Ser Pro Arg Gly Lys 
145                 150                 155                 160 


Asn Ile Gln Gly Gly Lys Thr Leu Ser Val Ser Gln Leu Glu Leu Gln 
                165                 170                 175     


Asp Ser Gly Thr Trp Thr Cys Thr Val Leu Gln Asn Gln Lys Lys Val 
            180                 185                 190         


Glu Phe Lys Ile Asp Ile Val Val Leu Ala Ala Ala Asp Pro Glu Pro 
        195                 200                 205             


Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
    210                 215                 220                 


Leu Leu Ala Gly Pro Asp Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
225                 230                 235                 240 


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
                245                 250                 255     


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
            260                 265                 270         


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
        275                 280                 285             


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
    290                 295                 300                 


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
305                 310                 315                 320 


Leu Pro Glu Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
                325                 330                 335     


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
            340                 345                 350         


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
        355                 360                 365             


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
    370                 375                 380                 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
385                 390                 395                 400 


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
                405                 410                 415     


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
            420                 425                 430         


Ser Leu Ser Pro Gly Lys Gly Gly Gly Gly Gly Asp Tyr Ala Asp Tyr 
        435                 440                 445             


Asp Gly Gly Tyr Tyr Tyr Asp Met Asp 
    450                 455         


<210>  14
<211>  478
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein MOLECULE-3


<220>
<221>  PEPTIDE
<222>  (1)..(478)
<223>  Fusion protein MOLECULE-3 (aa)

<400>  14

Met Asn Arg Gly Val Pro Phe Arg His Leu Leu Leu Val Leu Gln Leu 
1               5                   10                  15      


Ala Leu Leu Pro Ala Ala Thr Gln Gly Lys Lys Val Val Leu Gly Lys 
            20                  25                  30          


Lys Gly Asp Thr Val Glu Leu Thr Cys Thr Ala Ser Gln Lys Lys Ser 
        35                  40                  45              


Ile Gln Phe His Trp Lys Asn Ser Asn Gln Ile Lys Ile Leu Gly Asn 
    50                  55                  60                  


Gln Gly Ser Phe Leu Thr Lys Gly Pro Ser Lys Leu Asn Asp Arg Ala 
65                  70                  75                  80  


Asp Ser Arg Arg Ser Leu Trp Asp Gln Gly Asn Phe Pro Leu Ile Ile 
                85                  90                  95      


Lys Asn Leu Lys Ile Glu Asp Ser Asp Thr Tyr Ile Cys Glu Val Glu 
            100                 105                 110         


Asp Gln Lys Glu Glu Val Gln Leu Leu Val Phe Gly Leu Thr Ala Asn 
        115                 120                 125             


Ser Asp Thr His Leu Leu Gln Gly Gln Ser Leu Thr Leu Thr Leu Glu 
    130                 135                 140                 


Ser Pro Pro Gly Ser Ser Pro Ser Val Gln Cys Arg Ser Pro Arg Gly 
145                 150                 155                 160 


Lys Asn Ile Gln Gly Gly Lys Thr Leu Ser Val Ser Gln Leu Glu Leu 
                165                 170                 175     


Gln Asp Ser Gly Thr Trp Thr Cys Thr Val Leu Gln Asn Gln Lys Lys 
            180                 185                 190         


Val Glu Phe Lys Ile Asp Ile Val Val Leu Ala Glu Pro Lys Ser Cys 
        195                 200                 205             


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Ala 
    210                 215                 220                 


Gly Pro Asp Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
225                 230                 235                 240 


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
                245                 250                 255     


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
            260                 265                 270         


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
        275                 280                 285             


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
    290                 295                 300                 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Leu Pro Glu 
305                 310                 315                 320 


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
                325                 330                 335     


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
            340                 345                 350         


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
        355                 360                 365             


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
    370                 375                 380                 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
385                 390                 395                 400 


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
                405                 410                 415     


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
            420                 425                 430         


Pro Gly Lys Gly Gly Gly Gly Ala Ala Ala Tyr Thr Ser Leu Ile His 
        435                 440                 445             


Ser Leu Ile Glu Glu Ser Gln Asn Gln Gln Glu Lys Asn Glu Gln Glu 
    450                 455                 460                 


Leu Leu Glu Leu Asp Lys Trp Ala Ser Leu Trp Asn Trp Phe 
465                 470                 475             


<210>  15
<211>  468
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein MOLECULE-4 (aa)


<220>
<221>  PEPTIDE
<222>  (1)..(468)
<223>  Fusion protein MOLECULE-4 (aa)

<400>  15

Met Asn Arg Gly Val Pro Phe Arg His Leu Leu Leu Val Leu Gln Leu 
1               5                   10                  15      


Ala Leu Leu Pro Ala Ala Thr Gln Gly Lys Lys Val Val Leu Gly Lys 
            20                  25                  30          


Lys Gly Asp Thr Val Glu Leu Thr Cys Thr Ala Ser Gln Lys Lys Ser 
        35                  40                  45              


Ile Gln Phe His Trp Lys Asn Ser Asn Gln Ile Lys Ile Leu Gly Asn 
    50                  55                  60                  


Gln Gly Ser Phe Leu Thr Lys Gly Pro Ser Lys Leu Asn Asp Arg Ala 
65                  70                  75                  80  


Asp Ser Arg Arg Ser Leu Trp Asp Gln Gly Asn Phe Pro Leu Ile Ile 
                85                  90                  95      


Lys Asn Leu Lys Ile Glu Asp Ser Asp Thr Tyr Ile Cys Glu Val Glu 
            100                 105                 110         


Asp Gln Lys Glu Glu Val Gln Leu Leu Val Phe Gly Leu Thr Ala Asn 
        115                 120                 125             


Ser Asp Thr His Leu Leu Gln Gly Gln Ser Leu Thr Leu Thr Leu Glu 
    130                 135                 140                 


Ser Pro Pro Gly Ser Ser Pro Ser Val Gln Cys Arg Ser Pro Arg Gly 
145                 150                 155                 160 


Lys Asn Ile Gln Gly Gly Lys Thr Leu Ser Val Ser Gln Leu Glu Leu 
                165                 170                 175     


Gln Asp Ser Gly Thr Trp Thr Cys Thr Val Leu Gln Asn Gln Lys Lys 
            180                 185                 190         


Val Glu Phe Lys Ile Asp Ile Val Val Leu Ala Glu Pro Lys Ser Cys 
        195                 200                 205             


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Ala 
    210                 215                 220                 


Gly Pro Asp Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
225                 230                 235                 240 


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
                245                 250                 255     


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
            260                 265                 270         


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
        275                 280                 285             


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
    290                 295                 300                 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Leu Pro Glu 
305                 310                 315                 320 


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
                325                 330                 335     


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
            340                 345                 350         


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
        355                 360                 365             


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
    370                 375                 380                 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
385                 390                 395                 400 


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
                405                 410                 415     


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
            420                 425                 430         


Pro Gly Lys Gly Gly Gly Gly Asp Tyr Gln Val Ser Ser Pro Ile Tyr 
        435                 440                 445             


Asp Ile Asn Tyr Tyr Thr Ser Glu Pro Cys Gln Lys Ile Asn Val Lys 
    450                 455                 460                 


Gln Ile Ala Ala 
465             


<210>  16
<211>  529
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein MOLECULE-5 (aa)


<220>
<221>  PEPTIDE
<222>  (1)..(529)
<223>  Fusion protein MOLECULE-5 (aa)

<400>  16

Met Asn Arg Gly Val Pro Phe Arg His Leu Leu Leu Val Leu Gln Leu 
1               5                   10                  15      


Ala Leu Leu Pro Ala Ala Thr Gln Gly Lys Lys Val Val Leu Gly Lys 
            20                  25                  30          


Lys Gly Asp Thr Val Glu Leu Thr Cys Thr Ala Ser Gln Lys Lys Ser 
        35                  40                  45              


Ile Gln Phe His Trp Lys Asn Ser Asn Gln Ile Lys Ile Leu Gly Asn 
    50                  55                  60                  


Gln Gly Ser Phe Leu Thr Lys Gly Pro Ser Lys Leu Asn Asp Arg Ala 
65                  70                  75                  80  


Asp Ser Arg Arg Ser Leu Trp Asp Gln Gly Asn Phe Pro Leu Ile Ile 
                85                  90                  95      


Lys Asn Leu Lys Ile Glu Asp Ser Asp Thr Tyr Ile Cys Glu Val Glu 
            100                 105                 110         


Asp Gln Lys Glu Glu Val Gln Leu Leu Val Phe Gly Leu Thr Ala Asn 
        115                 120                 125             


Ser Asp Thr His Leu Leu Gln Gly Gln Ser Leu Thr Leu Thr Leu Glu 
    130                 135                 140                 


Ser Pro Pro Gly Ser Ser Pro Ser Val Gln Cys Arg Ser Pro Arg Gly 
145                 150                 155                 160 


Lys Asn Ile Gln Gly Gly Lys Thr Leu Ser Val Ser Gln Leu Glu Leu 
                165                 170                 175     


Gln Asp Ser Gly Thr Trp Thr Cys Thr Val Leu Gln Asn Gln Lys Lys 
            180                 185                 190         


Val Glu Phe Lys Ile Asp Ile Val Val Leu Ala Glu Pro Lys Ser Cys 
        195                 200                 205             


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Ala 
    210                 215                 220                 


Gly Pro Asp Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
225                 230                 235                 240 


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
                245                 250                 255     


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
            260                 265                 270         


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
        275                 280                 285             


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
    290                 295                 300                 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Leu Pro Glu 
305                 310                 315                 320 


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
                325                 330                 335     


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
            340                 345                 350         


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
        355                 360                 365             


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
    370                 375                 380                 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
385                 390                 395                 400 


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
                405                 410                 415     


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
            420                 425                 430         


Pro Gly Lys Gly Gly Gly Gly Asp Tyr Gln Val Ser Ser Pro Ile Tyr 
        435                 440                 445             


Asp Ile Asn Tyr Tyr Thr Ser Glu Pro Cys Gln Lys Ile Asn Val Lys 
    450                 455                 460                 


Gln Ile Ala Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
465                 470                 475                 480 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Tyr Thr Ser 
                485                 490                 495     


Leu Ile His Ser Leu Ile Glu Glu Ser Gln Asn Gln Gln Glu Lys Asn 
            500                 505                 510         


Glu Gln Glu Leu Leu Glu Leu Asp Lys Trp Ala Ser Leu Trp Asn Trp 
        515                 520                 525             


Phe 
    


<210>  17
<211>  435
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein MOLECULE-6 (aa)


<220>
<221>  PEPTIDE
<222>  (1)..(435)
<223>  Fusion protein MOLECULE-6 (aa)

<400>  17

Met Asn Arg Gly Val Pro Phe Arg His Leu Leu Leu Val Leu Gln Leu 
1               5                   10                  15      


Ala Leu Leu Pro Ala Ala Thr Gln Gly Lys Lys Val Val Leu Gly Lys 
            20                  25                  30          


Lys Gly Asp Thr Val Glu Leu Thr Cys Thr Ala Ser Gln Lys Lys Ser 
        35                  40                  45              


Ile Gln Phe His Trp Lys Asn Ser Asn Gln Ile Lys Ile Leu Gly Asn 
    50                  55                  60                  


Gln Gly Ser Phe Leu Thr Lys Gly Pro Ser Lys Leu Asn Asp Arg Ala 
65                  70                  75                  80  


Asp Ser Arg Arg Ser Leu Trp Asp Gln Gly Asn Phe Pro Leu Ile Ile 
                85                  90                  95      


Lys Asn Leu Lys Ile Glu Asp Ser Asp Thr Tyr Ile Cys Glu Val Glu 
            100                 105                 110         


Asp Gln Lys Glu Glu Val Gln Leu Leu Val Phe Gly Leu Thr Ala Asn 
        115                 120                 125             


Ser Asp Thr His Leu Leu Gln Gly Gln Ser Leu Thr Leu Thr Leu Glu 
    130                 135                 140                 


Ser Pro Pro Gly Ser Ser Pro Ser Val Gln Cys Arg Ser Pro Arg Gly 
145                 150                 155                 160 


Lys Asn Ile Gln Gly Gly Lys Thr Leu Ser Val Ser Gln Leu Glu Leu 
                165                 170                 175     


Gln Asp Ser Gly Thr Trp Thr Cys Thr Val Leu Gln Asn Gln Lys Lys 
            180                 185                 190         


Val Glu Phe Lys Ile Asp Ile Val Val Leu Ala Glu Pro Lys Ser Cys 
        195                 200                 205             


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Ala 
    210                 215                 220                 


Gly Pro Asp Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
225                 230                 235                 240 


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
                245                 250                 255     


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
            260                 265                 270         


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
        275                 280                 285             


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
    290                 295                 300                 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Leu Pro Glu 
305                 310                 315                 320 


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
                325                 330                 335     


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
            340                 345                 350         


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
        355                 360                 365             


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
    370                 375                 380                 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
385                 390                 395                 400 


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
                405                 410                 415     


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
            420                 425                 430         


Pro Gly Lys 
        435 


<210>  18
<211>  513
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein MOLECULE-7 (aa)


<220>
<221>  PEPTIDE
<222>  (1)..(513)
<223>  Fusion protein MOLECULE-7 (aa)

<400>  18

Met Trp Leu Gln Ser Leu Leu Leu Leu Gly Thr Val Ala Cys Ser Ile 
1               5                   10                  15      


Ser Lys Lys Val Val Leu Gly Lys Lys Gly Asp Thr Val Glu Leu Thr 
            20                  25                  30          


Cys Thr Ala Ser Gln Lys Lys Ser Ile Gln Phe His Trp Lys Asn Ser 
        35                  40                  45              


Asn Gln Ile Lys Ile Leu Gly Asn Gln Gly Ser Phe Leu Thr Lys Gly 
    50                  55                  60                  


Pro Ser Lys Leu Asn Asp Arg Ala Asp Ser Arg Arg Ser Leu Trp Asp 
65                  70                  75                  80  


Gln Gly Asn Phe Pro Leu Ile Ile Lys Asn Leu Lys Ile Glu Asp Ser 
                85                  90                  95      


Asp Thr Tyr Ile Cys Glu Val Glu Asp Gln Lys Glu Glu Val Gln Leu 
            100                 105                 110         


Leu Val Phe Gly Leu Thr Ala Asn Ser Asp Thr His Leu Leu Gln Gly 
        115                 120                 125             


Gln Ser Leu Thr Leu Thr Leu Glu Ser Pro Pro Gly Ser Ser Pro Ser 
    130                 135                 140                 


Val Gln Cys Arg Ser Pro Arg Gly Lys Asn Ile Gln Gly Gly Lys Thr 
145                 150                 155                 160 


Leu Ser Val Ser Gln Leu Glu Leu Gln Asp Ser Gly Thr Trp Thr Cys 
                165                 170                 175     


Thr Val Leu Gln Asn Gln Lys Lys Val Glu Phe Lys Ile Asp Ile Val 
            180                 185                 190         


Val Leu Ala Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
        195                 200                 205             


Cys Pro Ala Pro Glu Leu Leu Ala Gly Pro Asp Val Phe Leu Phe Pro 
    210                 215                 220                 


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
225                 230                 235                 240 


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
                245                 250                 255     


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
            260                 265                 270         


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
        275                 280                 285             


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
    290                 295                 300                 


Asn Lys Ala Leu Pro Leu Pro Glu Glu Lys Thr Ile Ser Lys Ala Lys 
305                 310                 315                 320 


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
                325                 330                 335     


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
            340                 345                 350         


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
        355                 360                 365             


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
    370                 375                 380                 


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
385                 390                 395                 400 


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
                405                 410                 415     


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly Gly Gly Ser 
            420                 425                 430         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        435                 440                 445             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    450                 455                 460                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Tyr Thr Ser 
465                 470                 475                 480 


Leu Ile His Ser Leu Ile Glu Glu Ser Gln Asn Gln Gln Glu Lys Asn 
                485                 490                 495     


Glu Gln Glu Leu Leu Glu Leu Asp Lys Trp Ala Ser Leu Trp Asn Trp 
            500                 505                 510         


Phe 
    


<210>  19
<211>  483
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein MOLECULE-8 (aa)


<220>
<221>  PEPTIDE
<222>  (1)..(483)
<223>  Fusion protein MOLECULE-8 (aa)

<400>  19

Met Trp Leu Gln Ser Leu Leu Leu Leu Gly Thr Val Ala Cys Ser Ile 
1               5                   10                  15      


Ser Lys Lys Val Val Leu Gly Lys Lys Gly Asp Thr Val Glu Leu Thr 
            20                  25                  30          


Cys Thr Ala Ser Gln Lys Lys Ser Ile Gln Phe His Trp Lys Asn Ser 
        35                  40                  45              


Asn Gln Ile Lys Ile Leu Gly Asn Gln Gly Ser Phe Leu Thr Lys Gly 
    50                  55                  60                  


Pro Ser Lys Leu Asn Asp Arg Ala Asp Ser Arg Arg Ser Leu Trp Asp 
65                  70                  75                  80  


Gln Gly Asn Phe Pro Leu Ile Ile Lys Asn Leu Lys Ile Glu Asp Ser 
                85                  90                  95      


Asp Thr Tyr Ile Cys Glu Val Glu Asp Gln Lys Glu Glu Val Gln Leu 
            100                 105                 110         


Leu Val Phe Gly Leu Thr Ala Asn Ser Asp Thr His Leu Leu Gln Gly 
        115                 120                 125             


Gln Ser Leu Thr Leu Thr Leu Glu Ser Pro Pro Gly Ser Ser Pro Ser 
    130                 135                 140                 


Val Gln Cys Arg Ser Pro Arg Gly Lys Asn Ile Gln Gly Gly Lys Thr 
145                 150                 155                 160 


Leu Ser Val Ser Gln Leu Glu Leu Gln Asp Ser Gly Thr Trp Thr Cys 
                165                 170                 175     


Thr Val Leu Gln Asn Gln Lys Lys Val Glu Phe Lys Ile Asp Ile Val 
            180                 185                 190         


Val Leu Ala Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
        195                 200                 205             


Cys Pro Ala Pro Glu Leu Leu Ala Gly Pro Asp Val Phe Leu Phe Pro 
    210                 215                 220                 


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
225                 230                 235                 240 


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
                245                 250                 255     


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
            260                 265                 270         


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
        275                 280                 285             


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
    290                 295                 300                 


Asn Lys Ala Leu Pro Leu Pro Glu Glu Lys Thr Ile Ser Lys Ala Lys 
305                 310                 315                 320 


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
                325                 330                 335     


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
            340                 345                 350         


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
        355                 360                 365             


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
    370                 375                 380                 


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
385                 390                 395                 400 


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
                405                 410                 415     


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly Gly Gly Ser 
            420                 425                 430         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Tyr 
        435                 440                 445             


Thr Ser Leu Ile His Ser Leu Ile Glu Glu Ser Gln Asn Gln Gln Glu 
    450                 455                 460                 


Lys Asn Glu Gln Glu Leu Leu Glu Leu Asp Lys Trp Ala Ser Leu Trp 
465                 470                 475                 480 


Asn Trp Phe 
            


<210>  20
<211>  509
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein MOLECULE-10 (aa)


<220>
<221>  PEPTIDE
<222>  (1)..(509)
<223>  Fusion protein MOLECULE-10 (aa)

<400>  20

Met Asn Arg Gly Val Pro Phe Arg His Leu Leu Leu Val Leu Gln Leu 
1               5                   10                  15      


Ala Leu Leu Pro Ala Ala Thr Gln Gly Lys Lys Val Val Leu Gly Lys 
            20                  25                  30          


Lys Gly Asp Thr Val Glu Leu Thr Cys Thr Ala Ser Gln Lys Lys Ser 
        35                  40                  45              


Ile Gln Phe His Trp Lys Asn Ser Asn Gln Ile Lys Ile Leu Gly Asn 
    50                  55                  60                  


Gln Gly Ser Phe Leu Thr Lys Gly Pro Ser Lys Leu Asn Asp Arg Ala 
65                  70                  75                  80  


Asp Ser Arg Arg Ser Leu Trp Asp Gln Gly Asn Phe Pro Leu Ile Ile 
                85                  90                  95      


Lys Asn Leu Lys Ile Glu Asp Ser Asp Thr Tyr Ile Cys Glu Val Glu 
            100                 105                 110         


Asp Gln Lys Glu Glu Val Gln Leu Leu Val Phe Gly Leu Thr Ala Asn 
        115                 120                 125             


Ser Asp Thr His Leu Leu Gln Gly Gln Ser Leu Thr Leu Thr Leu Glu 
    130                 135                 140                 


Ser Pro Pro Gly Ser Ser Pro Ser Val Gln Cys Arg Ser Pro Arg Gly 
145                 150                 155                 160 


Lys Asn Ile Gln Gly Gly Lys Thr Leu Ser Val Ser Gln Leu Glu Leu 
                165                 170                 175     


Gln Asp Ser Gly Thr Trp Thr Cys Thr Val Leu Gln Asn Gln Lys Lys 
            180                 185                 190         


Val Glu Phe Lys Ile Asp Ile Val Val Leu Ala Glu Pro Lys Ser Cys 
        195                 200                 205             


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Ala 
    210                 215                 220                 


Gly Pro Asp Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
225                 230                 235                 240 


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
                245                 250                 255     


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
            260                 265                 270         


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
        275                 280                 285             


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
    290                 295                 300                 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Leu Pro Glu 
305                 310                 315                 320 


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
                325                 330                 335     


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
            340                 345                 350         


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
        355                 360                 365             


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
    370                 375                 380                 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
385                 390                 395                 400 


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
                405                 410                 415     


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
            420                 425                 430         


Pro Gly Lys Gly Gly Gly Gly Asp Tyr Gln Val Ser Ser Pro Ile Tyr 
        435                 440                 445             


Asp Ile Asn Tyr Tyr Thr Ser Glu Pro Cys Gln Lys Ile Asn Val Lys 
    450                 455                 460                 


Gln Ile Ala Ala Gly Gly Gly Gly Ser Tyr Thr Ser Leu Ile His Ser 
465                 470                 475                 480 


Leu Ile Glu Glu Ser Gln Asn Gln Gln Glu Lys Asn Glu Gln Glu Leu 
                485                 490                 495     


Leu Glu Leu Asp Lys Trp Ala Ser Leu Trp Asn Trp Phe 
            500                 505                 


<210>  21
<211>  541
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein MOLECULE-11 (aa)


<220>
<221>  PEPTIDE
<222>  (1)..(541)
<223>  Fusion protein MOLECULE-11 (aa)

<400>  21

Met Trp Leu Gln Ser Leu Leu Leu Leu Gly Thr Val Ala Cys Ser Ile 
1               5                   10                  15      


Ser Lys Lys Val Val Leu Gly Lys Lys Gly Asp Thr Val Glu Leu Thr 
            20                  25                  30          


Cys Thr Ala Ser Gln Lys Lys Ser Ile Gln Phe His Trp Lys Asn Ser 
        35                  40                  45              


Asn Gln Ile Lys Ile Leu Gly Asn Gln Gly Ser Phe Leu Thr Lys Gly 
    50                  55                  60                  


Pro Ser Lys Leu Asn Asp Arg Ala Asp Ser Arg Arg Ser Leu Trp Asp 
65                  70                  75                  80  


Gln Gly Asn Phe Pro Leu Ile Ile Lys Asn Leu Lys Ile Glu Asp Ser 
                85                  90                  95      


Asp Thr Tyr Ile Cys Glu Val Glu Asp Gln Lys Glu Glu Val Gln Leu 
            100                 105                 110         


Leu Val Phe Gly Leu Thr Ala Asn Ser Asp Thr His Leu Leu Gln Gly 
        115                 120                 125             


Gln Ser Leu Thr Leu Thr Leu Glu Ser Pro Pro Gly Ser Ser Pro Ser 
    130                 135                 140                 


Val Gln Cys Arg Ser Pro Arg Gly Lys Asn Ile Gln Gly Gly Lys Thr 
145                 150                 155                 160 


Leu Ser Val Ser Gln Leu Glu Leu Gln Asp Ser Gly Thr Trp Thr Cys 
                165                 170                 175     


Thr Val Leu Gln Asn Gln Lys Lys Val Glu Phe Lys Ile Asp Ile Val 
            180                 185                 190         


Val Leu Ala Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
        195                 200                 205             


Cys Pro Ala Pro Glu Leu Leu Ala Gly Pro Asp Val Phe Leu Phe Pro 
    210                 215                 220                 


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
225                 230                 235                 240 


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
                245                 250                 255     


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
            260                 265                 270         


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
        275                 280                 285             


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
    290                 295                 300                 


Asn Lys Ala Leu Pro Leu Pro Glu Glu Lys Thr Ile Ser Lys Ala Lys 
305                 310                 315                 320 


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
                325                 330                 335     


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
            340                 345                 350         


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
        355                 360                 365             


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
    370                 375                 380                 


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
385                 390                 395                 400 


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
                405                 410                 415     


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly Gly Gly Asp 
            420                 425                 430         


Tyr Gln Val Ser Ser Pro Ile Tyr Asp Ile Asn Tyr Tyr Thr Ser Glu 
        435                 440                 445             


Pro Cys Gln Lys Ile Asn Val Lys Gln Ile Ala Ala Gly Gly Gly Gly 
    450                 455                 460                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
465                 470                 475                 480 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
                485                 490                 495     


Gly Gly Gly Ser Gly Gly Gly Gly Ser Tyr Thr Ser Leu Ile His Ser 
            500                 505                 510         


Leu Ile Glu Glu Ser Gln Asn Gln Gln Glu Lys Asn Glu Gln Glu Leu 
        515                 520                 525             


Leu Glu Leu Asp Lys Trp Ala Ser Leu Trp Asn Trp Phe 
    530                 535                 540     


<210>  22
<211>  300
<212>  DNA
<213>  Homo sapiens


<220>
<221>  gene
<222>  (1)..(300)
<223>  D1 domain of human CD4 receptor (nt)

<400>  22
aagaaagtgg tgctgggcaa aaagggcgac accgtggaac tgacctgcac cgccagccag       60

aagaagtcca tccagttcca ctggaagaac agcaaccaga tcaagatcct gggcaaccag      120

ggcagcttcc tgaccaaggg ccccagcaag ctgaacgaca gagccgactc tcggcggagc      180

ctgtgggacc agggcaattt cccactgatc atcaagaacc tgaagatcga ggacagcgac      240

acctacatct gcgaggtgga agatcagaaa gaagaggtgc agctgctggt gttcggcctg      300


<210>  23
<211>  234
<212>  DNA
<213>  Homo sapiens


<220>
<221>  gene
<222>  (1)..(234)
<223>  D2 domain of human CD4 receptor (nt)

<400>  23
accgccaact ccgacaccca tctgctgcag ggccagagcc tgaccctgac actggaaagc       60

cctccaggca gctcccccag cgtgcagtgt agaagccctc ggggcaagaa catccagggc      120

ggcaagacac tgagcgtgtc ccagctggaa ctgcaggaca gcggcacatg gacctgtacc      180

gtgctgcaga accagaaaaa ggtggaattc aagatcgaca tcgtggtgct ggcc            234


<210>  24
<211>  696
<212>  DNA
<213>  Homo sapiens


<220>
<221>  gene
<222>  (1)..(696)
<223>  Fc portion of human IgG1

<400>  24
gagcccaaga gctgcgacaa gacccacacc tgtccccctt gtcctgcccc tgaactgctg       60

ggcggaccta gcgtgttcct gttcccccca aagcccaagg acaccctgat gatctcccgg      120

acccccgaag tgacctgcgt ggtggtggat gtgtcccacg aggaccctga agtgaagttc      180

aattggtacg tggacggcgt ggaagtgcac aacgccaaga ccaagcccag agaggaacag      240

tacaacagca cctaccgggt ggtgtccgtg ctgaccgtgc tgcaccagga ctggctgaac      300

ggcaaagagt acaagtgcaa ggtgtccaac aaggccctgc ctgcccccat cgagaaaacc      360

atcagcaagg ccaagggcca gccccgcgaa ccccaggtgt acacactgcc ccctagcagg      420

gacgagctga ccaagaacca ggtgtccctg acctgtctcg tgaagggctt ttacccctcc      480

gatatcgccg tggaatggga gagcaacggc cagcccgaga acaactacaa gaccaccccc      540

cctgtgctgg actccgacgg ctcattcttc ctgtacagca aactgaccgt ggacaagagc      600

cggtggcagc agggcaacgt gttcagctgc agcgtgatgc acgaggccct gcacaaccac      660

tacacccaga agtccctgtc cctgagccct ggcaaa                                696


<210>  25
<211>  696
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Fc portion of the human IgG1 with G236A, S293D, A330L and I332E 
       point mutations (nt)


<220>
<221>  gene
<222>  (1)..(696)
<223>  Fc portion of the human IgG1 with G236A, S239D, A330L and I332E 
       point mutations (nt)

<400>  25
gagcccaaga gctgcgacaa gacccacacc tgtccccctt gtcctgcccc tgaactgctg       60

gccggacccg acgtgttcct gttcccccca aagcccaagg acaccctgat gatctcccgg      120

acccccgaag tgacctgcgt ggtggtggat gtgtcccacg aggaccctga agtgaagttc      180

aattggtacg tggacggcgt ggaagtgcac aacgccaaga ccaagcccag agaggaacag      240

tacaacagca cctaccgggt ggtgtccgtg ctgacagtgc tgcaccagga ctggctgaac      300

ggcaaagagt acaagtgcaa ggtgtccaac aaggccctgc ctctgcccga ggaaaagacc      360

atcagcaagg ccaagggcca gcccagggaa ccccaggtgt acacactgcc ccccagcaga      420

gatgagctga ccaagaacca ggtgtccctg acctgtctcg tgaagggctt ttacccctcc      480

gatatcgccg tggaatggga gagcaacggc cagcccgaga acaactacaa gaccaccccc      540

cctgtgctgg actccgacgg ctcattcttc ctgtactcca agctgaccgt ggacaagagc      600

agatggcagc agggcaacgt gttcagctgc tccgtgatgc acgaggccct gcacaaccac      660

tacacccaga agtccctgag cctgagccca ggcaaa                                696


<210>  26
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Linker polypeptide (nt)


<220>
<221>  gene
<222>  (1)..(15)
<223>  Linker polypeptide (nt)

<400>  26
ggcggagggg gatct                                                        15


<210>  27
<211>  87
<212>  DNA
<213>  Homo sapiens


<220>
<221>  gene
<222>  (1)..(87)
<223>  5' terminal region of the human CCR5 receptor (nt)

<400>  27
gattatcagg tgtccagccc catctacgac atcaactact acaccagcga gccctgccag       60

aaaatcaacg tgaagcagat cgccgct                                           87


<210>  28
<211>  108
<212>  DNA
<213>  Human immunodeficiency virus


<220>
<221>  gene
<222>  (1)..(108)
<223>  T-20 polypeptide (nt)

<400>  28
tacacaagcc tgatccacag cctgatcgag gaaagccaga accagcagga aaagaacgag       60

caggaactgc tggaactgga caagtgggcc agcctgtgga attggttc                   108


<210>  29
<211>  117
<212>  DNA
<213>  Human immunodeficiency virus


<220>
<221>  gene
<222>  (1)..(117)
<223>  T-1249 polypeptide (nt)

<400>  29
tggcaggaat gggaacagaa aattaccgcg ctgctggaac aggcgcagat tcagcaggaa       60

aaaaacgaat atgaactgca gaaactggat aaatgggcga gcctgtggga atggttt         117


<210>  30
<211>  102
<212>  DNA
<213>  Human immunodeficiency virus


<220>
<221>  gene
<222>  (1)..(102)
<223>  C34 polypeptide (nt)

<400>  30
tggatggaat gggatcgcga aattaacaac tataccagcc tgattcatag cctgattgaa       60

gaaagccaga accagcagga aaaaaacgaa caggaactgc tg                         102


<210>  31
<211>  114
<212>  DNA
<213>  Human immunodeficiency virus


<220>
<221>  gene
<222>  (1)..(114)
<223>  T-2635 polypeptide (nt)

<400>  31
accacctggg aagcgtggga tcgcgcgatt gcggaatatg cggcgcgcat tgaagcgctg       60

attcgcgcgg cgcaggaaca gcaggaaaaa aacgaagcgg cgctgcgcga actg            114


<210>  32
<211>  1230
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cDNA MOLECULE-0 (nt)


<220>
<221>  gene
<222>  (1)..(1230)
<223>  cDNA MOLECULE-0 (nt)

<400>  32
aagaaagtgg tgctgggcaa aaagggcgac accgtggaac tgacctgcac cgccagccag       60

aagaagtcca tccagttcca ctggaagaac agcaaccaga tcaagatcct gggcaaccag      120

ggcagcttcc tgaccaaggg ccccagcaag ctgaacgaca gagccgactc tcggcggagc      180

ctgtgggacc agggcaattt cccactgatc atcaagaacc tgaagatcga ggacagcgac      240

acctacatct gcgaggtgga agatcagaaa gaagaggtgc agctgctggt gttcggcctg      300

accgccaact ccgacaccca tctgctgcag ggccagagcc tgaccctgac actggaaagc      360

cctccaggca gctcccccag cgtgcagtgt agaagccctc ggggcaagaa catccagggc      420

ggcaagacac tgagcgtgtc ccagctggaa ctgcaggaca gcggcacatg gacctgtacc      480

gtgctgcaga accagaaaaa ggtggaattc aagatcgaca tcgtggtgct ggccgagccc      540

aagagctgcg acaagaccca cacctgtccc ccttgtcctg cccctgaact gctgggcgga      600

cctagcgtgt tcctgttccc cccaaagccc aaggacaccc tgatgatctc ccggaccccc      660

gaagtgacct gcgtggtggt ggatgtgtcc cacgaggacc ctgaagtgaa gttcaattgg      720

tacgtggacg gcgtggaagt gcacaacgcc aagaccaagc ccagagagga acagtacaac      780

agcacctacc gggtggtgtc cgtgctgacc gtgctgcacc aggactggct gaacggcaaa      840

gagtacaagt gcaaggtgtc caacaaggcc ctgcctgccc ccatcgagaa aaccatcagc      900

aaggccaagg gccagccccg cgaaccccag gtgtacacac tgccccctag cagggacgag      960

ctgaccaaga accaggtgtc cctgacctgt ctcgtgaagg gcttttaccc ctccgatatc     1020

gccgtggaat gggagagcaa cggccagccc gagaacaact acaagaccac cccccctgtg     1080

ctggactccg acggctcatt cttcctgtac agcaaactga ccgtggacaa gagccggtgg     1140

cagcagggca acgtgttcag ctgcagcgtg atgcacgagg ccctgcacaa ccactacacc     1200

cagaagtccc tgtccctgag ccctggcaaa                                      1230


<210>  33
<211>  1374
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cDNA MOLECULE-1 (nt)


<220>
<221>  gene
<222>  (1)..(1374)
<223>  cDNA MOLECULE-1 (nt)

<400>  33
atgcctatgg gaagcctgca gcctctggcc accctgtacc tgctgggaat gctggtggcc       60

tccgtgctgg ccaagaaagt ggtgctgggc aaaaagggcg acaccgtgga actgacctgc      120

accgccagcc agaagaagtc catccagttc cactggaaga acagcaacca gatcaagatc      180

ctgggcaacc agggcagctt cctgaccaag ggccccagca agctgaacga cagagccgac      240

tctcggcgga gcctgtggga ccagggcaat ttcccactga tcatcaagaa cctgaagatc      300

gaggacagcg acacctacat ctgcgaggtg gaagatcaga aagaagaggt gcagctgctg      360

gtgttcggcc tgaccgccaa ctccgacacc catctgctgc agggccagag cctgaccctg      420

acactggaaa gccctccagg cagcagcccc agcgtgcagt gtagaagccc cagaggcaag      480

aacatccagg gcggcaagac cctgagcgtg tcccagctgg aactgcagga tagcggcacc      540

tggacctgca cagtgctgca gaaccagaaa aaggtggaat tcaagatcga catcgtggtg      600

ctggccgctg ccgaccctga gcctaagagc tgcgacaaga cccacacctg tcccccttgt      660

cctgcccctg aactgctggg cggacctagc gtgttcctgt tccccccaaa gcccaaggac      720

accctgatga tctcccggac ccccgaagtg acctgcgtgg tggtggatgt gtcccacgag      780

gaccctgaag tgaagttcaa ttggtacgtg gacggcgtgg aagtgcacaa cgccaagacc      840

aagcccagag aggaacagta caacagcacc taccgggtgg tgtccgtgct gaccgtgctg      900

caccaggact ggctgaacgg caaagagtac aagtgcaagg tgtccaacaa ggccctgcct      960

gcccccatcg agaaaaccat cagcaaggcc aagggccagc cccgcgaacc ccaggtgtac     1020

acactgcccc ctagcaggga cgagctgacc aagaaccagg tgtccctgac ctgtctcgtg     1080

aagggctttt acccctccga tatcgccgtg gaatgggaga gcaacggcca gcccgagaac     1140

aactacaaga ccaccccccc tgtgctggac tccgacggct cattcttcct gtacagcaaa     1200

ctgaccgtgg acaagagccg gtggcagcag ggcaacgtgt tcagctgcag cgtgatgcac     1260

gaggccctgc acaaccacta cacccagaag tccctgtccc tgagccctgg caaaggcggc     1320

ggaggcggag attacgccga ttacgatggc ggctactact acgacatgga ctga           1374


<210>  34
<211>  1374
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cDNA MOLECULE-2 (nt)


<220>
<221>  gene
<222>  (1)..(1374)
<223>  cDNA MOLECULE-2 (nt)

<400>  34
atgcctatgg gaagcctgca gcctctggcc accctgtacc tgctgggaat gctggtggcc       60

tccgtgctgg ccaagaaagt ggtgctgggc aaaaagggcg acaccgtgga actgacctgc      120

accgccagcc agaagaagtc catccagttc cactggaaga acagcaacca gatcaagatc      180

ctgggcaacc agggcagctt cctgaccaag ggccccagca agctgaacga cagagccgac      240

tctcggcgga gcctgtggga ccagggcaat ttcccactga tcatcaagaa cctgaagatc      300

gaggacagcg acacctacat ctgcgaggtg gaagatcaga aagaagaggt gcagctgctg      360

gtgttcggcc tgaccgccaa ctccgacacc catctgctgc agggccagag cctgaccctg      420

acactggaaa gccctccagg cagcagcccc agcgtgcagt gtagaagccc cagaggcaag      480

aacatccagg gcggcaagac cctgagcgtg tcccagctgg aactgcagga tagcggcacc      540

tggacctgca cagtgctgca gaaccagaaa aaggtggaat tcaagatcga catcgtggtg      600

ctggccgctg ccgaccctga gcctaagagc tgcgacaaga cccacacctg tcccccttgt      660

cctgcccctg aactgctggc cggacccgac gtgttcctgt tccccccaaa gcccaaggac      720

accctgatga tctcccggac ccccgaagtg acctgcgtgg tggtggatgt gtcccacgag      780

gaccctgaag tgaagttcaa ttggtacgtg gacggcgtgg aagtgcacaa cgccaagacc      840

aagcccagag aggaacagta caacagcacc taccgggtgg tgtccgtgct gaccgtgctg      900

caccaggact ggctgaacgg caaagagtac aagtgcaagg tgtccaacaa ggccctgcct      960

ctgcccgagg aaaagaccat cagcaaggcc aagggccagc ccagggaacc ccaggtgtac     1020

acactgcccc ccagcagaga tgagctgacc aagaaccagg tgtccctgac ctgtctcgtg     1080

aagggctttt acccctccga tatcgccgtg gaatgggaga gcaacggcca gcccgagaac     1140

aactacaaga ccaccccccc tgtgctggac tccgacggct cattcttcct gtacagcaaa     1200

ctgaccgtgg acaagagccg gtggcagcag ggcaacgtgt tcagctgcag cgtgatgcac     1260

gaggccctgc acaaccacta cacccagaag tccctgtccc tgagccctgg caaaggcggc     1320

ggaggcggag attacgccga ttacgatggc ggctactact acgacatgga ctga           1374


<210>  35
<211>  1437
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cDNA MOLECULE-3 (nt)


<220>
<221>  gene
<222>  (1)..(1437)
<223>  cDNA MOLECULE-3 (nt)

<400>  35
atgaatagag gcgtgccctt ccggcatctg ctgctggtgc tgcagctggc tctgctgcct       60

gctgccaccc agggcaagaa agtggtgctg ggcaaaaagg gcgacaccgt ggaactgacc      120

tgcaccgcca gccagaagaa gtccatccag ttccactgga agaacagcaa ccagatcaag      180

atcctgggca accagggcag cttcctgacc aagggcccca gcaagctgaa cgacagagcc      240

gactctcggc ggagcctgtg ggaccagggc aatttcccac tgatcatcaa gaacctgaag      300

atcgaggaca gcgacaccta catctgcgag gtggaagatc agaaagaaga ggtgcagctg      360

ctggtgttcg gcctgaccgc caactccgac acccatctgc tgcagggcca gagcctgacc      420

ctgacactgg aaagccctcc aggcagctcc cccagcgtgc agtgtagaag ccctcggggc      480

aagaacatcc agggcggcaa gacactgagc gtgtcccagc tggaactgca ggacagcggc      540

acatggacct gtaccgtgct gcagaaccag aaaaaggtgg aattcaagat cgacatcgtg      600

gtgctggccg agcccaagag ctgcgacaag acccacacct gtcccccttg tcctgcccct      660

gaactgctgg ccggacccga cgtgttcctg ttccccccaa agcccaagga caccctgatg      720

atctcccgga cccccgaagt gacctgcgtg gtggtggatg tgtcccacga ggaccctgaa      780

gtgaagttca attggtacgt ggacggcgtg gaagtgcaca acgccaagac caagcccaga      840

gaggaacagt acaacagcac ctaccgggtg gtgtccgtgc tgacagtgct gcaccaggac      900

tggctgaacg gcaaagagta caagtgcaag gtgtccaaca aggccctgcc tctgcccgag      960

gaaaagacca tcagcaaggc caagggccag cccagggaac cccaggtgta cacactgccc     1020

cccagcagag atgagctgac caagaaccag gtgtccctga cctgtctcgt gaagggcttt     1080

tacccctccg atatcgccgt ggaatgggag agcaacggcc agcccgagaa caactacaag     1140

accacccccc ctgtgctgga ctccgacggc tcattcttcc tgtactccaa gctgaccgtg     1200

gacaagagca gatggcagca gggcaacgtg ttcagctgct ccgtgatgca cgaggccctg     1260

cacaaccact acacccagaa gtccctgagc ctgagcccag gcaaaggcgg aggcggagcg     1320

gccgcgtaca catctctgat ccacagcctg atcgaggaaa gccagaacca gcaggaaaag     1380

aacgagcagg aactgctgga actggacaag tgggccagcc tgtggaattg gttctga        1437


<210>  36
<211>  1407
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cDNA MOLECULE-4 (nt)


<220>
<221>  gene
<222>  (1)..(1407)
<223>  cDNA MOLECULE-4 (nt)

<400>  36
atgaatagag gcgtgccctt ccggcatctg ctgctggtgc tgcagctggc tctgctgcct       60

gctgccaccc agggcaagaa agtggtgctg ggcaaaaagg gcgacaccgt ggaactgacc      120

tgcaccgcca gccagaagaa gtccatccag ttccactgga agaacagcaa ccagatcaag      180

atcctgggca accagggcag cttcctgacc aagggcccca gcaagctgaa cgacagagcc      240

gactctcggc ggagcctgtg ggaccagggc aatttcccac tgatcatcaa gaacctgaag      300

atcgaggaca gcgacaccta catctgcgag gtggaagatc agaaagaaga ggtgcagctg      360

ctggtgttcg gcctgaccgc caactccgac acccatctgc tgcagggcca gagcctgacc      420

ctgacactgg aaagccctcc aggcagctcc cccagcgtgc agtgtagaag ccctcggggc      480

aagaacatcc agggcggcaa gacactgagc gtgtcccagc tggaactgca ggacagcggc      540

acatggacct gtaccgtgct gcagaaccag aaaaaggtgg aattcaagat cgacatcgtg      600

gtgctggccg agcccaagag ctgcgacaag acccacacct gtcccccttg tcctgcccct      660

gaactgctgg ccggacccga cgtgttcctg ttccccccaa agcccaagga caccctgatg      720

atctcccgga cccccgaagt gacctgcgtg gtggtggatg tgtcccacga ggaccctgaa      780

gtgaagttca attggtacgt ggacggcgtg gaagtgcaca acgccaagac caagcccaga      840

gaggaacagt acaacagcac ctaccgggtg gtgtccgtgc tgacagtgct gcaccaggac      900

tggctgaacg gcaaagagta caagtgcaag gtgtccaaca aggccctgcc tctgcccgag      960

gaaaagacca tcagcaaggc caagggccag cccagggaac cccaggtgta cacactgccc     1020

cccagcagag atgagctgac caagaaccag gtgtccctga cctgtctcgt gaagggcttt     1080

tacccctccg atatcgccgt ggaatgggag agcaacggcc agcccgagaa caactacaag     1140

accacccccc ctgtgctgga ctccgacggc tcattcttcc tgtactccaa gctgaccgtg     1200

gacaagagca gatggcagca gggcaacgtg ttcagctgct ccgtgatgca cgaggccctg     1260

cacaaccact acacccagaa gtccctgagc ctgagcccag gcaaaggcgg cggaggcgat     1320

tatcaggtgt ccagccccat ctacgacatc aactactaca ccagcgagcc ctgccagaaa     1380

atcaacgtga agcagatcgc cgcctga                                         1407


<210>  37
<211>  1593
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cDNA MOLECULE-5 (nt)


<220>
<221>  gene
<222>  (1)..(1593)
<223>  cDNA MOLECULE-5 (nt)

<400>  37
atgaatagag gcgtgccctt ccggcatctg ctgctggtgc tgcagctggc tctgctgcct       60

gctgccaccc agggcaagaa agtggtgctg ggcaaaaagg gcgacaccgt ggaactgacc      120

tgcaccgcca gccagaagaa gtccatccag ttccactgga agaacagcaa ccagatcaag      180

atcctgggca accagggcag cttcctgacc aagggcccca gcaagctgaa cgacagagcc      240

gactctcggc ggagcctgtg ggaccagggc aatttcccac tgatcatcaa gaacctgaag      300

atcgaggaca gcgacaccta catctgcgag gtggaagatc agaaagaaga ggtgcagctg      360

ctggtgttcg gcctgaccgc caactccgac acccatctgc tgcagggcca gagcctgacc      420

ctgacactgg aaagccctcc aggcagctcc cccagcgtgc agtgtagaag ccctcggggc      480

aagaacatcc agggcggcaa gacactgagc gtgtcccagc tggaactgca ggacagcggc      540

acatggacct gtaccgtgct gcagaaccag aaaaaggtgg aattcaagat cgacatcgtg      600

gtgctggccg agcccaagag ctgcgacaag acccacacct gtcccccttg tcctgcccct      660

gaactgctgg ccggacccga cgtgttcctg ttccccccaa agcccaagga caccctgatg      720

atctcccgga cccccgaagt gacctgcgtg gtggtggatg tgtcccacga ggaccctgaa      780

gtgaagttca attggtacgt ggacggcgtg gaagtgcaca acgccaagac caagcccaga      840

gaggaacagt acaacagcac ctaccgggtg gtgtccgtgc tgacagtgct gcaccaggac      900

tggctgaacg gcaaagagta caagtgcaag gtgtccaaca aggccctgcc tctgcccgag      960

gaaaagacca tcagcaaggc caagggccag cccagggaac cccaggtgta cacactgccc     1020

cccagcagag atgagctgac caagaaccag gtgtccctga cctgtctcgt gaagggcttt     1080

tacccctccg atatcgccgt ggaatgggag agcaacggcc agcccgagaa caactacaag     1140

accacccccc ctgtgctgga ctccgacggc tcattcttcc tgtactccaa gctgaccgtg     1200

gacaagagca gatggcagca gggcaacgtg ttcagctgct ccgtgatgca cgaggccctg     1260

cacaaccact acacccagaa gtccctgagc ctgagcccag gcaaaggcgg cggaggcgat     1320

tatcaggtgt ccagccccat ctacgacatc aactactaca ccagcgagcc ctgccagaaa     1380

atcaacgtga agcagatcgc cgctggcgga gggggatctg ggggcggagg aagcggaggc     1440

ggaggatcag gcgggggagg ctctggggga ggcggatctt acacaagcct gatccacagc     1500

ctgatcgagg aaagccagaa ccagcaggaa aagaacgagc aggaactgct ggaactggac     1560

aagtgggcca gcctgtggaa ttggttctga tga                                  1593


<210>  38
<211>  1311
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cDNA MOLECULE-6 (nt)


<220>
<221>  gene
<222>  (1)..(1311)
<223>  cDNA MOLECULE-6 (nt)

<400>  38
atgaatagag gcgtgccctt ccggcatctg ctgctggtgc tgcagctggc tctgctgcct       60

gctgccaccc agggcaagaa agtggtgctg ggcaaaaagg gcgacaccgt ggaactgacc      120

tgcaccgcca gccagaagaa gtccatccag ttccactgga agaacagcaa ccagatcaag      180

atcctgggca accagggcag cttcctgacc aagggcccca gcaagctgaa cgacagagcc      240

gactctcggc ggagcctgtg ggaccagggc aatttcccac tgatcatcaa gaacctgaag      300

atcgaggaca gcgacaccta catctgcgag gtggaagatc agaaagaaga ggtgcagctg      360

ctggtgttcg gcctgaccgc caactccgac acccatctgc tgcagggcca gagcctgacc      420

ctgacactgg aaagccctcc aggcagctcc cccagcgtgc agtgtagaag ccctcggggc      480

aagaacatcc agggcggcaa gacactgagc gtgtcccagc tggaactgca ggacagcggc      540

acatggacct gtaccgtgct gcagaaccag aaaaaggtgg aattcaagat cgacatcgtg      600

gtgctggccg agcccaagag ctgcgacaag acccacacct gtcccccttg tcctgcccct      660

gaactgctgg ccggacccga cgtgttcctg ttccccccaa agcccaagga caccctgatg      720

atctcccgga cccccgaagt gacctgcgtg gtggtggatg tgtcccacga ggaccctgaa      780

gtgaagttca attggtacgt ggacggcgtg gaagtgcaca acgccaagac caagcccaga      840

gaggaacagt acaacagcac ctaccgggtg gtgtccgtgc tgacagtgct gcaccaggac      900

tggctgaacg gcaaagagta caagtgcaag gtgtccaaca aggccctgcc tctgcccgag      960

gaaaagacca tcagcaaggc caagggccag cccagggaac cccaggtgta cacactgccc     1020

cccagcagag atgagctgac caagaaccag gtgtccctga cctgtctcgt gaagggcttt     1080

tacccctccg atatcgccgt ggaatgggag agcaacggcc agcccgagaa caactacaag     1140

accacccccc ctgtgctgga ctccgacggc tcattcttcc tgtactccaa gctgaccgtg     1200

gacaagagca gatggcagca gggcaacgtg ttcagctgct ccgtgatgca cgaggccctg     1260

cacaaccact acacccagaa gtccctgagc ctgagccccg gcaagtgatg a              1311


<210>  39
<211>  1542
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cDNA MOLECULE-7 (nt)


<220>
<221>  gene
<222>  (1)..(1542)
<223>  cDNA MOLECULE-7 (nt)

<400>  39
atgtggctgc agtctctgct gctgctgggc accgtggcct gcagcatcag caagaaagtg       60

gtgctgggca agaaaggcga caccgtggaa ctgacctgca ccgccagcca gaagaagtcc      120

atccagttcc actggaagaa cagcaaccag atcaagatcc tgggcaacca gggcagcttc      180

ctgaccaagg gccccagcaa gctgaacgac agagccgact ctcggcggag cctgtgggac      240

cagggcaatt tcccactgat catcaagaac ctgaagatcg aggacagcga cacctacatc      300

tgcgaggtgg aagatcagaa agaagaggtg cagctgctgg tgttcggcct gaccgccaac      360

tccgacaccc atctgctgca gggccagagc ctgaccctga cactggaaag ccctccaggc      420

agcagcccca gcgtgcagtg tagaagcccc agaggcaaga acatccaggg cggcaagacc      480

ctgagcgtgt cccagctgga actgcaggat agcggcacct ggacctgtac cgtgctgcag      540

aaccagaaaa aggtggaatt caagatcgac atcgtggtgc tggccgagcc caagagctgc      600

gacaagaccc acacctgtcc cccttgtcct gcccctgaac tgctggccgg acccgacgtg      660

ttcctgttcc ccccaaagcc caaggacacc ctgatgatct cccggacccc cgaagtgacc      720

tgcgtggtgg tggatgtgtc ccacgaggac cctgaagtga agttcaattg gtacgtggac      780

ggcgtggaag tgcacaacgc caagaccaag cccagagagg aacagtacaa cagcacctac      840

cgggtggtgt ccgtgctgac agtgctgcac caggactggc tgaacggcaa agagtacaag      900

tgcaaggtgt ccaacaaggc cctgcctctg cccgaggaaa agaccatctc caaggccaag      960

ggccagccca gggaacccca ggtgtacaca ctgcccccca gcagagatga gctgaccaag     1020

aaccaggtgt ccctgacctg tctcgtgaag ggcttttacc cctccgatat cgccgtggaa     1080

tgggagagca acggccagcc cgagaacaac tacaagacca ccccccctgt gctggactcc     1140

gacggctcat tcttcctgta ctccaagctg accgtggaca agagccggtg gcagcagggc     1200

aacgtgttca gctgcagcgt gatgcacgag gccctgcaca accactacac ccagaagtcc     1260

ctgagcctga gcccaggcaa aggcggcgga ggatctggcg gaggcggatc tgggggcgga     1320

ggaagtgggg gagggggaag cggaggggga ggctcaggcg ggggaggaag cggaggcggg     1380

ggaagtggcg gcggaggcag tggcggggga ggctccgggg gaggcggctc ttatacaagc     1440

ctgatccaca gcctgatcga ggaaagccag aaccagcagg aaaagaacga gcaggaactg     1500

ctggaactgg acaagtgggc cagcctgtgg aattggttct ga                        1542


<210>  40
<211>  1452
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cDNA MOLECULE-8 (nt)


<220>
<221>  gene
<222>  (1)..(1452)
<223>  cDNA MOLECULE-8 (nt)

<400>  40
atgtggctgc agtctctgct gctgctgggc accgtggcct gcagcatcag caagaaagtg       60

gtgctgggca agaaaggcga caccgtggaa ctgacctgca ccgccagcca gaagaagtcc      120

atccagttcc actggaagaa cagcaaccag atcaagatcc tgggcaacca gggcagcttc      180

ctgaccaagg gccccagcaa gctgaacgac agagccgact ctcggcggag cctgtgggac      240

cagggcaatt tcccactgat catcaagaac ctgaagatcg aggacagcga cacctacatc      300

tgcgaggtgg aagatcagaa agaagaggtg cagctgctgg tgttcggcct gaccgccaac      360

tccgacaccc atctgctgca gggccagagc ctgaccctga cactggaaag ccctccaggc      420

agcagcccca gcgtgcagtg tagaagcccc agaggcaaga acatccaggg cggcaagacc      480

ctgagcgtgt cccagctgga actgcaggat agcggcacct ggacctgtac cgtgctgcag      540

aaccagaaaa aggtggaatt caagatcgac atcgtggtgc tggccgagcc caagagctgc      600

gacaagaccc acacctgtcc cccttgtcct gcccctgaac tgctggccgg acccgacgtg      660

ttcctgttcc ccccaaagcc caaggacacc ctgatgatct cccggacccc cgaagtgacc      720

tgcgtggtgg tggatgtgtc ccacgaggac cctgaagtga agttcaattg gtacgtggac      780

ggcgtggaag tgcacaacgc caagaccaag cccagagagg aacagtacaa cagcacctac      840

cgggtggtgt ccgtgctgac agtgctgcac caggactggc tgaacggcaa agagtacaag      900

tgcaaggtgt ccaacaaggc cctgcctctg cccgaggaaa agaccatctc caaggccaag      960

ggccagccca gggaacccca ggtgtacaca ctgcccccca gcagagatga gctgaccaag     1020

aaccaggtgt ccctgacctg tctcgtgaag ggcttttacc cctccgatat cgccgtggaa     1080

tgggagagca acggccagcc cgagaacaac tacaagacca ccccccctgt gctggactcc     1140

gacggctcat tcttcctgta ctccaagctg accgtggaca agagccggtg gcagcagggc     1200

aacgtgttca gctgcagcgt gatgcacgag gccctgcaca accactacac ccagaagtcc     1260

ctgagcctga gcccaggcaa aggcggcgga ggatctggcg gaggcggatc tgggggcgga     1320

ggaagtgggg ggggaggctc ttacacaagc ctgatccaca gcctgatcga ggaaagccag     1380

aaccagcagg aaaagaacga gcaggaactg ctggaactgg acaagtgggc cagcctgtgg     1440

aattggttct ga                                                         1452


<210>  41
<211>  1503
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cDNA MOLECULE-10 (nt)


<220>
<221>  gene
<222>  (1)..(1503)
<223>  cDNA MOLECULE-10 (nt)

<400>  41
atgtggctgc agtctctgct gctgctgggc accgtggcct gcagcatcag caagaaagtg       60

gtgctgggca agaaaggcga caccgtggaa ctgacctgca ccgccagcca gaagaagtcc      120

atccagttcc actggaagaa cagcaaccag atcaagatcc tgggcaacca gggcagcttc      180

ctgaccaagg gccccagcaa gctgaacgac agagccgact ctcggcggag cctgtgggac      240

cagggcaatt tcccactgat catcaagaac ctgaagatcg aggacagcga cacctacatc      300

tgcgaggtgg aagatcagaa agaagaggtg cagctgctgg tgttcggcct gaccgccaac      360

tccgacaccc atctgctgca gggccagagc ctgaccctga cactggaaag ccctccaggc      420

agcagcccca gcgtgcagtg tagaagcccc agaggcaaga acatccaggg cggcaagacc      480

ctgagcgtgt cccagctgga actgcaggat agcggcacct ggacctgtac cgtgctgcag      540

aaccagaaaa aggtggaatt caagatcgac atcgtggtgc tggccgagcc caagagctgc      600

gacaagaccc acacctgtcc cccttgtcct gcccctgaac tgctggccgg acccgacgtg      660

ttcctgttcc ccccaaagcc caaggacacc ctgatgatct cccggacccc cgaagtgacc      720

tgcgtggtgg tggatgtgtc ccacgaggac cctgaagtga agttcaattg gtacgtggac      780

ggcgtggaag tgcacaacgc caagaccaag cccagagagg aacagtacaa cagcacctac      840

cgggtggtgt ccgtgctgac agtgctgcac caggactggc tgaacggcaa agagtacaag      900

tgcaaggtgt ccaacaaggc cctgcctctg cccgaggaaa agaccatctc caaggccaag      960

ggccagccca gggaacccca ggtgtacaca ctgcccccca gcagagatga gctgaccaag     1020

aaccaggtgt ccctgacctg tctcgtgaag ggcttttacc cctccgatat cgccgtggaa     1080

tgggagagca acggccagcc cgagaacaac tacaagacca ccccccctgt gctggactcc     1140

gacggctcat tcttcctgta ctccaagctg accgtggaca agagccggtg gcagcagggc     1200

aacgtgttca gctgcagcgt gatgcacgag gccctgcaca accactacac ccagaagtcc     1260

ctgagcctga gcccaggcaa aggcggcgga ggcgattatc aggtgtccag ccccatctac     1320

gacatcaact actacaccag cgagccctgc cagaaaatca acgtgaagca gatcgccgct     1380

ggcggagggg gctacacatc tctgatccac agcctgatcg aggaaagcca gaaccagcag     1440

gaaaagaacg agcaggaact gctggaactg gacaagtggg ccagcctgtg gaattggttc     1500

tga                                                                   1503


<210>  42
<211>  1626
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cDNA MOLECULE-11 (nt)


<220>
<221>  gene
<222>  (1)..(1626)
<223>  cDNA MOLECULE-11 (nt)

<400>  42
atgtggctgc agtctctgct gctgctgggc accgtggcct gcagcatcag caagaaagtg       60

gtgctgggca agaaaggcga caccgtggaa ctgacctgca ccgccagcca gaagaagtcc      120

atccagttcc actggaagaa cagcaaccag atcaagatcc tgggcaacca gggcagcttc      180

ctgaccaagg gccccagcaa gctgaacgac agagccgact ctcggcggag cctgtgggac      240

cagggcaatt tcccactgat catcaagaac ctgaagatcg aggacagcga cacctacatc      300

tgcgaggtgg aagatcagaa agaagaggtg cagctgctgg tgttcggcct gaccgccaac      360

tccgacaccc atctgctgca gggccagagc ctgaccctga cactggaaag ccctccaggc      420

agcagcccca gcgtgcagtg tagaagcccc agaggcaaga acatccaggg cggcaagacc      480

ctgagcgtgt cccagctgga actgcaggat agcggcacct ggacctgtac cgtgctgcag      540

aaccagaaaa aggtggaatt caagatcgac atcgtggtgc tggccgagcc caagagctgc      600

gacaagaccc acacctgtcc cccttgtcct gcccctgaac tgctggccgg acccgacgtg      660

ttcctgttcc ccccaaagcc caaggacacc ctgatgatct cccggacccc cgaagtgacc      720

tgcgtggtgg tggatgtgtc ccacgaggac cctgaagtga agttcaattg gtacgtggac      780

ggcgtggaag tgcacaacgc caagaccaag cccagagagg aacagtacaa cagcacctac      840

cgggtggtgt ccgtgctgac agtgctgcac caggactggc tgaacggcaa agagtacaag      900

tgcaaggtgt ccaacaaggc cctgcctctg cccgaggaaa agaccatctc caaggccaag      960

ggccagccca gggaacccca ggtgtacaca ctgcccccca gcagagatga gctgaccaag     1020

aaccaggtgt ccctgacctg tctcgtgaag ggcttttacc cctccgatat cgccgtggaa     1080

tgggagagca acggccagcc cgagaacaac tacaagacca ccccccctgt gctggactcc     1140

gacggctcat tcttcctgta ctccaagctg accgtggaca agagccggtg gcagcagggc     1200

aacgtgttca gctgcagcgt gatgcacgag gccctgcaca accactacac ccagaagtcc     1260

ctgagcctga gcccaggcaa aggcggcgga ggcgattatc aggtgtccag ccccatctac     1320

gacatcaact actacaccag cgagccctgc cagaaaatca acgtgaagca gatcgccgct     1380

ggcggagggg gatctggggg cggaggaagc ggaggcggag gatcaggcgg gggaggctct     1440

gggggaggcg gcagtggggg gggaggaagt ggcggaggcg gctcaggcgg aggcggaagc     1500

gggggaggcg gatcttacac aagcctgatc cacagcctga tcgaggaaag ccagaaccag     1560

caggaaaaga acgagcagga actgctggaa ctggacaagt gggccagcct gtggaattgg     1620

ttctga                                                                1626


