                         SEQUENCE LISTING

<110>  UNIVERSITAT AUTNOMA DE BARCELONA
 
<120>  Secreted splicing variant of mammal Klotho as a medicament for 
       cognition and behaviour impairments

<130>  T 2015/033

<160>  19    

<170>  PatentIn version 3.5

<210>  1
<211>  549
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Pro Ala Ser Ala Pro Pro Arg Arg Pro Arg Pro Pro Pro Pro Ser 
1               5                   10                  15      


Leu Ser Leu Leu Leu Val Leu Leu Gly Leu Gly Gly Arg Arg Leu Arg 
            20                  25                  30          


Ala Glu Pro Gly Asp Gly Ala Gln Thr Trp Ala Arg Val Ser Arg Pro 
        35                  40                  45              


Pro Ala Pro Glu Ala Ala Gly Leu Phe Gln Gly Thr Phe Pro Asp Gly 
    50                  55                  60                  


Phe Leu Trp Ala Val Gly Ser Ala Ala Tyr Gln Thr Glu Gly Gly Trp 
65                  70                  75                  80  


Gln Gln His Gly Lys Gly Ala Ser Ile Trp Asp Thr Phe Thr His His 
                85                  90                  95      


Pro Leu Ala Pro Pro Gly Asp Ser Arg Asn Ala Ser Leu Pro Leu Gly 
            100                 105                 110         


Ala Pro Ser Pro Leu Gln Pro Ala Thr Gly Asp Val Ala Ser Asp Ser 
        115                 120                 125             


Tyr Asn Asn Val Phe Arg Asp Thr Glu Ala Leu Arg Glu Leu Gly Val 
    130                 135                 140                 


Thr His Tyr Arg Phe Ser Ile Ser Trp Ala Arg Val Leu Pro Asn Gly 
145                 150                 155                 160 


Ser Ala Gly Val Pro Asn Arg Glu Gly Leu Arg Tyr Tyr Arg Arg Leu 
                165                 170                 175     


Leu Glu Arg Leu Arg Glu Leu Gly Val Gln Pro Val Val Thr Leu Tyr 
            180                 185                 190         


His Trp Asp Leu Pro Gln Arg Leu Gln Asp Ala Tyr Gly Gly Trp Ala 
        195                 200                 205             


Asn Arg Ala Leu Ala Asp His Phe Arg Asp Tyr Ala Glu Leu Cys Phe 
    210                 215                 220                 


Arg His Phe Gly Gly Gln Val Lys Tyr Trp Ile Thr Ile Asp Asn Pro 
225                 230                 235                 240 


Tyr Val Val Ala Trp His Gly Tyr Ala Thr Gly Arg Leu Ala Pro Gly 
                245                 250                 255     


Ile Arg Gly Ser Pro Arg Leu Gly Tyr Leu Val Ala His Asn Leu Leu 
            260                 265                 270         


Leu Ala His Ala Lys Val Trp His Leu Tyr Asn Thr Ser Phe Arg Pro 
        275                 280                 285             


Thr Gln Gly Gly Gln Val Ser Ile Ala Leu Ser Ser His Trp Ile Asn 
    290                 295                 300                 


Pro Arg Arg Met Thr Asp His Ser Ile Lys Glu Cys Gln Lys Ser Leu 
305                 310                 315                 320 


Asp Phe Val Leu Gly Trp Phe Ala Lys Pro Val Phe Ile Asp Gly Asp 
                325                 330                 335     


Tyr Pro Glu Ser Met Lys Asn Asn Leu Ser Ser Ile Leu Pro Asp Phe 
            340                 345                 350         


Thr Glu Ser Glu Lys Lys Phe Ile Lys Gly Thr Ala Asp Phe Phe Ala 
        355                 360                 365             


Leu Cys Phe Gly Pro Thr Leu Ser Phe Gln Leu Leu Asp Pro His Met 
    370                 375                 380                 


Lys Phe Arg Gln Leu Glu Ser Pro Asn Leu Arg Gln Leu Leu Ser Trp 
385                 390                 395                 400 


Ile Asp Leu Glu Phe Asn His Pro Gln Ile Phe Ile Val Glu Asn Gly 
                405                 410                 415     


Trp Phe Val Ser Gly Thr Thr Lys Arg Asp Asp Ala Lys Tyr Met Tyr 
            420                 425                 430         


Tyr Leu Lys Lys Phe Ile Met Glu Thr Leu Lys Ala Ile Lys Leu Asp 
        435                 440                 445             


Gly Val Asp Val Ile Gly Tyr Thr Ala Trp Ser Leu Met Asp Gly Phe 
    450                 455                 460                 


Glu Trp His Arg Gly Tyr Ser Ile Arg Arg Gly Leu Phe Tyr Val Asp 
465                 470                 475                 480 


Phe Leu Ser Gln Asp Lys Met Leu Leu Pro Lys Ser Ser Ala Leu Phe 
                485                 490                 495     


Tyr Gln Lys Leu Ile Glu Lys Asn Gly Phe Pro Pro Leu Pro Glu Asn 
            500                 505                 510         


Gln Pro Leu Glu Gly Thr Phe Pro Cys Asp Phe Ala Trp Gly Val Val 
        515                 520                 525             


Asp Asn Tyr Ile Gln Val Ser Gln Leu Thr Lys Pro Ile Ser Ser Leu 
    530                 535                 540                 


Thr Lys Pro Tyr His 
545                 


<210>  2
<211>  550
<212>  PRT
<213>  Mus musculus

<400>  2

Met Leu Ala Arg Ala Pro Pro Arg Arg Pro Pro Arg Leu Val Leu Leu 
1               5                   10                  15      


Arg Leu Leu Leu Leu His Leu Leu Leu Leu Ala Leu Arg Ala Arg Cys 
            20                  25                  30          


Leu Ser Ala Glu Pro Gly Gln Gly Ala Gln Thr Trp Ala Arg Phe Ala 
        35                  40                  45              


Arg Ala Pro Ala Pro Glu Ala Ala Gly Leu Leu His Asp Thr Phe Pro 
    50                  55                  60                  


Asp Gly Phe Leu Trp Ala Val Gly Ser Ala Ala Tyr Gln Thr Glu Gly 
65                  70                  75                  80  


Gly Trp Arg Gln His Gly Lys Gly Ala Ser Ile Trp Asp Thr Phe Thr 
                85                  90                  95      


His His Ser Gly Ala Ala Pro Ser Asp Ser Pro Ile Val Val Ala Pro 
            100                 105                 110         


Ser Gly Ala Pro Ser Pro Pro Leu Ser Ser Thr Gly Asp Val Ala Ser 
        115                 120                 125             


Asp Ser Tyr Asn Asn Val Tyr Arg Asp Thr Glu Gly Leu Arg Glu Leu 
    130                 135                 140                 


Gly Val Thr His Tyr Arg Phe Ser Ile Ser Trp Ala Arg Val Leu Pro 
145                 150                 155                 160 


Asn Gly Thr Ala Gly Thr Pro Asn Arg Glu Gly Leu Arg Tyr Tyr Arg 
                165                 170                 175     


Arg Leu Leu Glu Arg Leu Arg Glu Leu Gly Val Gln Pro Val Val Thr 
            180                 185                 190         


Leu Tyr His Trp Asp Leu Pro Gln Arg Leu Gln Asp Thr Tyr Gly Gly 
        195                 200                 205             


Trp Ala Asn Arg Ala Leu Ala Asp His Phe Arg Asp Tyr Ala Glu Leu 
    210                 215                 220                 


Cys Phe Arg His Phe Gly Gly Gln Val Lys Tyr Trp Ile Thr Ile Asp 
225                 230                 235                 240 


Asn Pro Tyr Val Val Ala Trp His Gly Tyr Ala Thr Gly Arg Leu Ala 
                245                 250                 255     


Pro Gly Val Arg Gly Ser Ser Arg Leu Gly Tyr Leu Val Ala His Asn 
            260                 265                 270         


Leu Leu Leu Ala His Ala Lys Val Trp His Leu Tyr Asn Thr Ser Phe 
        275                 280                 285             


Arg Pro Thr Gln Gly Gly Arg Val Ser Ile Ala Leu Ser Ser His Trp 
    290                 295                 300                 


Ile Asn Pro Arg Arg Met Thr Asp Tyr Asn Ile Arg Glu Cys Gln Lys 
305                 310                 315                 320 


Ser Leu Asp Phe Val Leu Gly Trp Phe Ala Lys Pro Ile Phe Ile Asp 
                325                 330                 335     


Gly Asp Tyr Pro Glu Ser Met Lys Asn Asn Leu Ser Ser Leu Leu Pro 
            340                 345                 350         


Asp Phe Thr Glu Ser Glu Lys Arg Leu Ile Arg Gly Thr Ala Asp Phe 
        355                 360                 365             


Phe Ala Leu Ser Phe Gly Pro Thr Leu Ser Phe Gln Leu Leu Asp Pro 
    370                 375                 380                 


Asn Met Lys Phe Arg Gln Leu Glu Ser Pro Asn Leu Arg Gln Leu Leu 
385                 390                 395                 400 


Ser Trp Ile Asp Leu Glu Tyr Asn His Pro Pro Ile Phe Ile Val Glu 
                405                 410                 415     


Asn Gly Trp Phe Val Ser Gly Thr Thr Lys Arg Asp Asp Ala Lys Tyr 
            420                 425                 430         


Met Tyr Tyr Leu Lys Lys Phe Ile Met Glu Thr Leu Lys Ala Ile Arg 
        435                 440                 445             


Leu Asp Gly Val Asp Val Ile Gly Tyr Thr Ala Trp Ser Leu Met Asp 
    450                 455                 460                 


Gly Phe Glu Trp His Arg Gly Tyr Ser Ile Arg Arg Gly Leu Phe Tyr 
465                 470                 475                 480 


Val Asp Phe Leu Ser Gln Asp Lys Glu Leu Leu Pro Lys Ser Ser Ala 
                485                 490                 495     


Leu Phe Tyr Gln Lys Leu Ile Glu Asp Asn Gly Phe Pro Pro Leu Pro 
            500                 505                 510         


Glu Asn Gln Pro Leu Glu Gly Thr Phe Pro Cys Asp Phe Ala Trp Gly 
        515                 520                 525             


Val Val Asp Asn Tyr Val Gln Val Ser Pro Leu Thr Lys Pro Ser Val 
    530                 535                 540                 


Gly Leu Leu Leu Pro His 
545                 550 


<210>  3
<211>  3024
<212>  DNA
<213>  Artificial

<220>
<223>  Gene construct comprising nucleotide sequence coding for Mus 
       musculus klotho secreted splicing variant

<400>  3
tctagacatg gctcgacaga tctcaatatt ggccattagc catattattc attggttata       60

tagcataaat caatattggc tattggccat tgcatacgtt gtatctatat cataatatgt      120

acatttatat tggctcatgt ccaatatgac cgccatgttg gcattgatta ttgactagtt      180

attaatagta atcaattacg gggtcattag ttcatagccc atatatggag ttccgcgtta      240

cataacttac ggtaaatggc ccgcctggct gaccgcccaa cgacccccgc ccattgacgt      300

caataatgac gtatgttccc atagtaacgc caatagggac tttccattga cgtcaatggg      360

tggagtattt acggtaaact gcccacttgg cagtacatca agtgtatcat atgccaagtc      420

cgccccctat tgacgtcaat gacggtaaat ggcccgcctg gcattatgcc cagtacatga      480

ccttacggga ctttcctact tggcagtaca tctacgtatt agtcatcgct attaccatgg      540

tgatgcggtt ttggcagtac accaatgggc gtggatagcg gtttgactca cggggatttc      600

caagtctcca ccccattgac gtcaatggga gtttgttttg gcaccaaaat caacgggact      660

ttccaaaatg tcgtaacaac tgcgatcgcc cgccccgttg acgcaaatgg gcggtaggcg      720

tgtacggtgg gaggtctata taagcagagc tcgtttagtg aaccgtcaga tcactagaag      780

ctttattgcg gtagtttatc acagttaaat tgctaacgca gtcagtgctt ctgacacaac      840

agtctcgaac ttaagctgca gtgactctct taaggtagcc ttgcagaagt tggtcgtgag      900

gcactgggca ggtaagtatc aaggttacaa gacaggttta aggagaccaa tagaaactgg      960

gcttgtcgag acagagaaga ctcttgcgtt tctgataggc acctattggt cttactgaca     1020

tccactttgc ctttctctcc acaggtgtcc actcccagtt caattacagc tcttaaggct     1080

agagtactta atacgactca ctataggcta gcaatgctcg cccgcgcccc tcctcgccgc     1140

ccgccgcggc tggtgctgct ccgtttgctg ttgctgcatc tgctgctgct cgccctgcgc     1200

gcccgctgcc tgagcgctga gccgggtcag ggcgcgcaga cctgggctcg cttcgcgcgc     1260

gctcctgccc cagaggccgc tggcctcctc cacgacacct tccccgacgg tttcctctgg     1320

gcggtaggca gcgccgccta tcagaccgag ggcggctggc gacagcacgg caaaggcgcg     1380

tccatctggg acactttcac ccatcactct ggggcggccc cgtccgactc cccgatcgtc     1440

gtggcgccgt cgggtgcccc gtcgcctccc ctgtcctcca ctggagatgt ggccagcgat     1500

agttacaaca acgtctaccg cgacacagag gggctgcgcg aactgggggt cacccactac     1560

cgcttctcca tatcgtgggc gcgggtgctc cccaatggca ccgcgggcac tcccaaccgc     1620

gaggggctgc gctactaccg gcggctgctg gagcggctgc gggagctggg cgtgcagccg     1680

gtggttaccc tgtaccattg ggacctgcca cagcgcctgc aggacaccta tggcggatgg     1740

gccaatcgcg ccctggccga ccatttcagg gattatgccg agctctgctt ccgccacttc     1800

ggtggtcagg tcaagtactg gatcaccatt gacaacccct acgtggtggc ctggcacggg     1860

tatgccaccg ggcgcctggc cccgggcgtg aggggcagct ccaggctcgg gtacctggtt     1920

gcccacaacc tacttttggc tcatgccaaa gtctggcatc tctacaacac ctctttccgc     1980

cccacacagg gaggccgggt gtctatcgcc ttaagctccc attggatcaa tcctcgaaga     2040

atgactgact ataatatcag agaatgccag aagtctcttg actttgtgct aggctggttt     2100

gccaaaccca tatttattga tggcgactac ccagagagta tgaagaacaa cctctcgtct     2160

cttctgcctg attttactga atctgagaag aggctcatca gaggaactgc tgactttttt     2220

gctctctcct tcggaccaac cttgagcttt cagctattgg accctaacat gaagttccgc     2280

caattggagt ctcccaacct gaggcagctt ctgtcttgga tagatctgga atataaccac     2340

cctccaatat ttattgtgga aaatggctgg tttgtctcgg gaaccaccaa aagggatgat     2400

gccaaatata tgtattatct caagaagttc ataatggaaa ccttaaaagc aatcagactg     2460

gatggggtcg acgtcattgg gtacaccgcg tggtcgctca tggacggttt cgagtggcat     2520

aggggctaca gcatccggcg aggactcttc tacgttgact ttctgagtca ggacaaggag     2580

ctgttgccaa agtcttcggc cttgttctac caaaagctga tagaggacaa tggctttcct     2640

cctttacctg aaaaccagcc ccttgaaggg acatttccct gtgactttgc ttggggagtt     2700

gttgacaact acgttcagct gagtcctttg acaaaaccca gtgtcggcct cttgcttcct     2760

cactaagggc cgcttccctt tagtgagggt taatgcttcg agcagacatg ataagataca     2820

ttgatgagtt tggacaaacc acaactagaa tgcagtgaaa aaaatgcttt atttgtgaaa     2880

tttgtgatgc tattgcttta tttgtaacca ttataagctg caataaacaa gttaacaaca     2940

acaattgcat tcattttatg tttcaggttc agggggagat gtgggaggtt ttttaaagca     3000

agtaaaacct ctacaaatgt ggta                                            3024


<210>  4
<211>  3018
<212>  DNA
<213>  Artificial

<220>
<223>  Gene construct comprising nucleotide sequence coding for Homo 
       sapiens klotho secreted splicing variant

<400>  4
tctagacatg gctcgacaga tctcaatatt ggccattagc catattattc attggttata       60

tagcataaat caatattggc tattggccat tgcatacgtt gtatctatat cataatatgt      120

acatttatat tggctcatgt ccaatatgac cgccatgttg gcattgatta ttgactagtt      180

attaatagta atcaattacg gggtcattag ttcatagccc atatatggag ttccgcgtta      240

cataacttac ggtaaatggc ccgcctggct gaccgcccaa cgacccccgc ccattgacgt      300

caataatgac gtatgttccc atagtaacgc caatagggac tttccattga cgtcaatggg      360

tggagtattt acggtaaact gcccacttgg cagtacatca agtgtatcat atgccaagtc      420

cgccccctat tgacgtcaat gacggtaaat ggcccgcctg gcattatgcc cagtacatga      480

ccttacggga ctttcctact tggcagtaca tctacgtatt agtcatcgct attaccatgg      540

tgatgcggtt ttggcagtac accaatgggc gtggatagcg gtttgactca cggggatttc      600

caagtctcca ccccattgac gtcaatggga gtttgttttg gcaccaaaat caacgggact      660

ttccaaaatg tcgtaacaac tgcgatcgcc cgccccgttg acgcaaatgg gcggtaggcg      720

tgtacggtgg gaggtctata taagcagagc tcgtttagtg aaccgtcaga tcactagaag      780

ctttattgcg gtagtttatc acagttaaat tgctaacgca gtcagtgctt ctgacacaac      840

agtctcgaac ttaagctgca gtgactctct taaggtagcc ttgcagaagt tggtcgtgag      900

gcactgggca ggtaagtatc aaggttacaa gacaggttta aggagaccaa tagaaactgg      960

gcttgtcgag acagagaaga ctcttgcgtt tctgataggc acctattggt cttactgaca     1020

tccactttgc ctttctctcc acaggtgtcc actcccagtt caattacagc tcttaaggct     1080

agagtactta atacgactca ctataggcta gcaatgcccg ccagcgcccc gccgcgccgc     1140

ccgcggccgc cgccgccgtc gctgtcgctg ctgctggtgc tgctgggcct gggcggccgc     1200

cgcctgcgtg cggagccggg cgacggcgcg cagacctggg cccgtgtctc gcggcctcct     1260

gcccccgagg ccgcgggcct cttccagggc accttccccg acggcttcct ctgggccgtg     1320

ggcagcgccg cctaccagac cgagggcggc tggcagcagc acggcaaggg tgcgtccatc     1380

tgggacacgt tcacccacca ccccctggca cccccgggag actcccggaa cgccagtctg     1440

ccgttgggcg ccccgtcgcc gctgcagccc gccaccgggg acgtagccag cgacagctac     1500

aacaacgtct tccgcgacac ggaggcgctg cgcgagctcg gggtcactca ctaccgcttc     1560

tccatctcgt gggcgcgagt gctccccaat ggcagcgcgg gcgtccccaa ccgcgagggg     1620

ctgcgctact accggcgcct gctggagcgg ctgcgggagc tgggcgtgca gcccgtggtc     1680

accctgtacc actgggacct gccccagcgc ctgcaggacg cctacggcgg ctgggccaac     1740

cgcgccctgg ccgaccactt cagggattac gcggagctct gcttccgcca cttcggcggt     1800

caggtcaagt actggatcac catcgacaac ccctacgtgg tggcctggca cggctacgcc     1860

accgggcgcc tggcccccgg catccggggc agcccgcggc tcgggtacct ggtggcgcac     1920

aacctcctcc tggctcatgc caaagtctgg catctctaca atacttcttt ccgtcccact     1980

cagggaggtc aggtgtccat tgccctaagc tctcactgga tcaatcctcg aagaatgacc     2040

gaccacagca tcaaagaatg tcaaaaatct ctggactttg tactaggttg gtttgccaaa     2100

cccgtattta ttgatggtga ctatcccgag agcatgaaga ataacctttc atctattctg     2160

cctgatttta ctgaatctga gaaaaagttc atcaaaggaa ctgctgactt ttttgctctt     2220

tgctttggac ccaccttgag ttttcaactt ttggaccctc acatgaagtt ccgccaattg     2280

gaatctccca acctgaggca actgctttcc tggattgacc ttgaatttaa ccatcctcaa     2340

atatttattg tggaaaatgg ctggtttgtc tcagggacca ccaagagaga tgatgccaaa     2400

tatatgtatt acctcaaaaa gttcatcatg gaaaccttaa aagccatcaa gctggatggg     2460

gtggatgtca tcgggtatac cgcatggtcc ctcatggatg gtttcgagtg gcacagaggt     2520

tacagcatca ggcgtggact cttctatgtt gactttctaa gccaggacaa gatgttgttg     2580

ccaaagtctt cagccttgtt ctaccaaaag ctgatagaga aaaatggctt ccctccttta     2640

cctgaaaatc agcccctaga agggacattt ccctgtgact ttgcttgggg agttgttgac     2700

aactacattc agctgagtcc tttgacaaaa cccagtgtcg gcctcttgct tcctcactaa     2760

gggccgcttc cctttagtga gggttaatgc ttcgagcaga catgataaga tacattgatg     2820

agtttggaca aaccacaact agaatgcagt gaaaaaaatg ctttatttgt gaaatttgtg     2880

atgctattgc tttatttgta accattataa gctgcaataa acaagttaac aacaacaatt     2940

gcattcattt tatgtttcag gttcaggggg agatgtggga ggttttttaa agcaagtaaa     3000

acctctacaa atgtggta                                                   3018


<210>  5
<211>  1650
<212>  DNA
<213>  Homo sapiens

<400>  5
atgcccgcca gcgccccgcc gcgccgcccg cggccgccgc cgccgtcgct gtcgctgctg       60

ctggtgctgc tgggcctggg cggccgccgc ctgcgtgcgg agccgggcga cggcgcgcag      120

acctgggccc gtgtctcgcg gcctcctgcc cccgaggccg cgggcctctt ccagggcacc      180

ttccccgacg gcttcctctg ggccgtgggc agcgccgcct accagaccga gggcggctgg      240

cagcagcacg gcaagggtgc gtccatctgg gacacgttca cccaccaccc cctggcaccc      300

ccgggagact cccggaacgc cagtctgccg ttgggcgccc cgtcgccgct gcagcccgcc      360

accggggacg tagccagcga cagctacaac aacgtcttcc gcgacacgga ggcgctgcgc      420

gagctcgggg tcactcacta ccgcttctcc atctcgtggg cgcgagtgct ccccaatggc      480

agcgcgggcg tccccaaccg cgaggggctg cgctactacc ggcgcctgct ggagcggctg      540

cgggagctgg gcgtgcagcc cgtggtcacc ctgtaccact gggacctgcc ccagcgcctg      600

caggacgcct acggcggctg ggccaaccgc gccctggccg accacttcag ggattacgcg      660

gagctctgct tccgccactt cggcggtcag gtcaagtact ggatcaccat cgacaacccc      720

tacgtggtgg cctggcacgg ctacgccacc gggcgcctgg cccccggcat ccggggcagc      780

ccgcggctcg ggtacctggt ggcgcacaac ctcctcctgg ctcatgccaa agtctggcat      840

ctctacaata cttctttccg tcccactcag ggaggtcagg tgtccattgc cctaagctct      900

cactggatca atcctcgaag aatgaccgac cacagcatca aagaatgtca aaaatctctg      960

gactttgtac taggttggtt tgccaaaccc gtatttattg atggtgacta tcccgagagc     1020

atgaagaata acctttcatc tattctgcct gattttactg aatctgagaa aaagttcatc     1080

aaaggaactg ctgacttttt tgctctttgc tttggaccca ccttgagttt tcaacttttg     1140

gaccctcaca tgaagttccg ccaattggaa tctcccaacc tgaggcaact gctttcctgg     1200

attgaccttg aatttaacca tcctcaaata tttattgtgg aaaatggctg gtttgtctca     1260

gggaccacca agagagatga tgccaaatat atgtattacc tcaaaaagtt catcatggaa     1320

accttaaaag ccatcaagct ggatggggtg gatgtcatcg ggtataccgc atggtccctc     1380

atggatggtt tcgagtggca cagaggttac agcatcaggc gtggactctt ctatgttgac     1440

tttctaagcc aggacaagat gttgttgcca aagtcttcag ccttgttcta ccaaaagctg     1500

atagagaaaa atggcttccc tcctttacct gaaaatcagc ccctagaagg gacatttccc     1560

tgtgactttg cttggggagt tgttgacaac tacattcaag taagtcagct gacaaaacca     1620

atcagcagtc tcaccaagcc ctatcactag                                      1650


<210>  6
<211>  1653
<212>  DNA
<213>  Mus musculus

<400>  6
atgctagccc gcgcccctcc tcgccgcccg ccgcggctgg tgctgctccg tttgctgttg       60

ctgcatctgc tgctgctcgc cctgcgcgcc cgctgcctga gcgctgagcc gggtcagggc      120

gcgcagacct gggctcgctt cgcgcgcgct cctgccccag aggccgctgg cctcctccac      180

gacaccttcc ccgacggttt cctctgggcg gtaggcagcg ccgcctatca gaccgagggc      240

ggctggcgac agcacggcaa aggcgcgtcc atctgggaca ctttcaccca tcactctggg      300

gcggccccgt ccgactcccc gatcgtcgtg gcgccgtcgg gtgccccgtc gcctcccctg      360

tcctccactg gagatgtggc cagcgatagt tacaacaacg tctaccgcga cacagagggg      420

ctgcgcgaac tgggggtcac ccactaccgc ttctccatat cgtgggcgcg ggtgctcccc      480

aatggcaccg cgggcactcc caaccgcgag gggctgcgct actaccggcg gctgctggag      540

cggctgcggg agctgggcgt gcagccggtg gttaccctgt accattggga cctgccacag      600

cgcctgcagg acacctatgg cggatgggcc aatcgcgccc tggccgacca tttcagggat      660

tatgccgagc tctgcttccg ccacttcggt ggtcaggtca agtactggat caccattgac      720

aacccctacg tggtggcctg gcacgggtat gccaccgggc gcctggcccc gggcgtgagg      780

ggcagctcca ggctcgggta cctggttgcc cacaacctac ttttggctca tgccaaagtc      840

tggcatctct acaacacctc tttccgcccc acacagggag gccgggtgtc tatcgcctta      900

agctcccatt ggatcaatcc tcgaagaatg actgactata atatcagaga atgccagaag      960

tctcttgact ttgtgctagg ctggtttgcc aaacccatat ttattgatgg cgactaccca     1020

gagagtatga agaacaacct ctcgtctctt ctgcctgatt ttactgaatc tgagaagagg     1080

ctcatcagag gaactgctga cttttttgct ctctccttcg gaccaacctt gagctttcag     1140

ctattggacc ctaacatgaa gttccgccaa ttggagtctc ccaacctgag gcagcttctg     1200

tcttggatag atctggaata taaccaccct ccaatattta ttgtggaaaa tggctggttt     1260

gtctcgggaa ccaccaaaag ggatgatgcc aaatatatgt attatctcaa gaagttcata     1320

atggaaacct taaaagcaat cagactggat ggggtcgacg tcattgggta caccgcgtgg     1380

tcgctcatgg acggtttcga gtggcatagg ggctacagca tccggcgagg actcttctac     1440

gttgactttc tgagtcagga caaggagctg ttgccaaagt cttcggcctt gttctaccaa     1500

aagctgatag aggacaatgg ctttcctcct ttacctgaaa accagcccct tgaagggaca     1560

tttccctgtg actttgcttg gggagttgtt gacaactacg ttcaagtaag tcctttgaca     1620

aaacccagtg tcggcctctt gcttcctcac taa                                  1653


<210>  7
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  forward primer

<400>  7
ttcaaacccg gaagtctttg                                                   20


<210>  8
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Reverse primer

<400>  8
ccaggcagac gttcacatta                                                   20


<210>  9
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Forward primer

<400>  9
tggctttcct cctttacctg                                                   20


<210>  10
<211>  18
<212>  DNA
<213>  Artificial

<220>
<223>  Reverse primer

<400>  10
gccgacactg ggttttgt                                                     18


<210>  11
<211>  14
<212>  PRT
<213>  Mus musculus

<400>  11

Ser Pro Leu Thr Lys Pro Ser Val Gly Leu Leu Leu Pro His 
1               5                   10                  


<210>  12
<211>  5421
<212>  DNA
<213>  Artificial

<220>
<223>  Plasmid pGG2


<220>
<221>  promoter
<222>  (206)..(955)
<223>  CMV IE enhancer/promoter

<220>
<221>  Intron
<222>  (1095)..(1227)
<223>  Intron from pCl-neo

<220>
<221>  misc_feature
<222>  (1227)..(1334)
<223>  Multiple Cloning Site (MCS)

<220>
<221>  polyA_signal
<222>  (1369)..(1590)
<223>  SV40 late poly A signal

<400>  12
cagcagctgc gcgctcgctc gctcactgag gccgcccggg caaagcccgg gcgtcgggcg       60

acctttggtc gcccggcctc agtgagcgag cgagcgcgca gagagggagt ggccaactcc      120

atcactaggg gttccttgta gttaatgatt aacccgccat gctacttatc tacgtagcca      180

tgctctagac atggctcgac agatctcaat attggccatt agccatatta ttcattggtt      240

atatagcata aatcaatatt ggctattggc cattgcatac gttgtatcta tatcataata      300

tgtacattta tattggctca tgtccaatat gaccgccatg ttggcattga ttattgacta      360

gttattaata gtaatcaatt acggggtcat tagttcatag cccatatatg gagttccgcg      420

ttacataact tacggtaaat ggcccgcctg gctgaccgcc caacgacccc cgcccattga      480

cgtcaataat gacgtatgtt cccatagtaa cgccaatagg gactttccat tgacgtcaat      540

gggtggagta tttacggtaa actgcccact tggcagtaca tcaagtgtat catatgccaa      600

gtccgccccc tattgacgtc aatgacggta aatggcccgc ctggcattat gcccagtaca      660

tgaccttacg ggactttcct acttggcagt acatctacgt attagtcatc gctattacca      720

tggtgatgcg gttttggcag tacaccaatg ggcgtggata gcggtttgac tcacggggat      780

ttccaagtct ccaccccatt gacgtcaatg ggagtttgtt ttggcaccaa aatcaacggg      840

actttccaaa atgtcgtaac aactgcgatc gcccgccccg ttgacgcaaa tgggcggtag      900

gcgtgtacgg tgggaggtct atataagcag agctcgttta gtgaaccgtc agatcactag      960

aagctttatt gcggtagttt atcacagtta aattgctaac gcagtcagtg cttctgacac     1020

aacagtctcg aacttaagct gcagtgactc tcttaaggta gccttgcaga agttggtcgt     1080

gaggcactgg gcaggtaagt atcaaggtta caagacaggt ttaaggagac caatagaaac     1140

tgggcttgtc gagacagaga agactcttgc gtttctgata ggcacctatt ggtcttactg     1200

acatccactt tgcctttctc tccacaggtg tccactccca gttcaattac agctcttaag     1260

gctagagtac ttaatacgac tcactatagg ctagcctcga cctcgagacg cgtgatatcg     1320

gatcccggcc ggcggccgct tccctttagt gagggttaat gcttcgagca gacatgataa     1380

gatacattga tgagtttgga caaaccacaa ctagaatgca gtgaaaaaaa tgctttattt     1440

gtgaaatttg tgatgctatt gctttatttg taaccattat aagctgcaat aaacaagtta     1500

acaacaacaa ttgcattcat tttatgtttc aggttcaggg ggagatgtgg gaggtttttt     1560

aaagcaagta aaacctctac aaatgtggta aaatccgata agggactaga gcatggctac     1620

gtagataagt agcatggcgg gttaatcatt aactacaagg aacccctagt gatggagttg     1680

gccactccct ctctgcgcgc tcgctcgctc actgaggccg ggcgaccaaa ggtcgcccga     1740

cgcccgggct ttgcccgggc ggcctcagtg agcgagcgag cgcgccagct ggcgtaatag     1800

cgaagaggcc cgcaccgatc gcccttccca acagttgcgc agcctgaatg gcgaatggaa     1860

ttccagacga ttgagcgtca aaatgtaggt atttccatga gcgtttttcc gttgcaatgg     1920

ctggcggtaa tattgttctg gatattacca gcaaggccga tagtttgagt tcttctactc     1980

aggcaagtga tgttattact aatcaaagaa gtattgcgac aacggttaat ttgcgtgatg     2040

gacagactct tttactcggt ggcctcactg attataaaaa cacttctcag gattctggcg     2100

taccgttcct gtctaaaatc cctttaatcg gcctcctgtt tagctcccgc tctgattcta     2160

acgaggaaag cacgttatac gtgctcgtca aagcaaccat agtacgcgcc ctgtagcggc     2220

gcattaagcg cggcgggtgt ggtggttacg cgcagcgtga ccgctacact tgccagcgcc     2280

ctagcgcccg ctcctttcgc tttcttccct tcctttctcg ccacgttcgc cggctttccc     2340

cgtcaagctc taaatcgggg gctcccttta gggttccgat ttagtgcttt acggcacctc     2400

gaccccaaaa aacttgatta gggtgatggt tcacgtagtg ggccatcgcc ctgatagacg     2460

gtttttcgcc ctttgacgtt ggagtccacg ttctttaata gtggactctt gttccaaact     2520

ggaacaacac tcaaccctat ctcggtctat tcttttgatt tataagggat tttgccgatt     2580

tcggcctatt ggttaaaaaa tgagctgatt taacaaaaat ttaacgcgaa ttttaacaaa     2640

atattaacgt ctacaattta aatatttgct tatacaatct tcctgttttt ggggcttttc     2700

tgattatcaa ccggggtaca tatgattgac atgctagttt tacgattacc gttcatcgat     2760

tctcttgttt gctccagact ctcaggcaat gacctgatag cctttgtaga gacctctcaa     2820

aaatagctac cctctccggc atgaatttat cagctagaac ggttgaatat catattgatg     2880

gtgatttgac tgtctccggc ctttctcacc cgtttgaatc tttacctaca cattactcag     2940

gcattgcatt taaaatatat gagggttcta aaaattttta tccttgcgtt gaaataaagg     3000

cttctcccgc aaaagtatta cagggtcata atgtttttgg tacaaccgat ttagctttat     3060

gctctgaggc tttattgctt aattttgcta attctttgcc ttgcctgtat gatttattgg     3120

atgttggaat cgcctgatgc ggtattttct ccttacgcat ctgtgcggta tttcacaccg     3180

catatggtgc actctcagta caatctgctc tgatgccgca tagttaagcc agccccgaca     3240

cccgccaaca cccgctgacg cgccctgacg ggcttgtctg ctcccggcat ccgcttacag     3300

acaagctgtg accgtctccg ggagctgcat gtgtcagagg ttttcaccgt catcaccgaa     3360

acgcgcgaga cgaaagggcc tcgtgatacg cctattttta taggttaatg tcatgataat     3420

aatggtttct tagacgtcag gtggcacttt tcggggaaat gtgcgcggaa cccctatttg     3480

tttatttttc taaatacatt caaatatgta tccgctcatg agacaataac cctgataaat     3540

gcttcaataa tattgaaaaa ggaagagtat gagtattcaa catttccgtg tcgcccttat     3600

tccctttttt gcggcatttt gccttcctgt ttttgctcac ccagaaacgc tggtgaaagt     3660

aaaagatgct gaagatcagt tgggtgcacg agtgggttac atcgaactgg atctcaacag     3720

cggtaagatc cttgagagtt ttcgccccga agaacgtttt ccaatgatga gcacttttaa     3780

agttctgcta tgtggcgcgg tattatcccg tattgacgcc gggcaagagc aactcggtcg     3840

ccgcatacac tattctcaga atgacttggt tgagtactca ccagtcacag aaaagcatct     3900

tacggatggc atgacagtaa gagaattatg cagtgctgcc ataaccatga gtgataacac     3960

tgcggccaac ttacttctga caacgatcgg aggaccgaag gagctaaccg cttttttgca     4020

caacatgggg gatcatgtaa ctcgccttga tcgttgggaa ccggagctga atgaagccat     4080

accaaacgac gagcgtgaca ccacgatgcc tgtagcaatg gcaacaacgt tgcgcaaact     4140

attaactggc gaactactta ctctagcttc ccggcaacaa ttaatagact ggatggaggc     4200

ggataaagtt gcaggaccac ttctgcgctc ggcccttccg gctggctggt ttattgctga     4260

taaatctgga gccggtgagc gtgggtctcg cggtatcatt gcagcactgg ggccagatgg     4320

taagccctcc cgtatcgtag ttatctacac gacggggagt caggcaacta tggatgaacg     4380

aaatagacag atcgctgaga taggtgcctc actgattaag cattggtaac tgtcagacca     4440

agtttactca tatatacttt agattgattt aaaacttcat ttttaattta aaaggatcta     4500

ggtgaagatc ctttttgata atctcatgac caaaatccct taacgtgagt tttcgttcca     4560

ctgagcgtca gaccccgtag aaaagatcaa aggatcttct tgagatcctt tttttctgcg     4620

cgtaatctgc tgcttgcaaa caaaaaaacc accgctacca gcggtggttt gtttgccgga     4680

tcaagagcta ccaactcttt ttccgaaggt aactggcttc agcagagcgc agataccaaa     4740

tactgtcctt ctagtgtagc cgtagttagg ccaccacttc aagaactctg tagcaccgcc     4800

tacatacctc gctctgctaa tcctgttacc agtggctgct gccagtggcg ataagtcgtg     4860

tcttaccggg ttggactcaa gacgatagtt accggataag gcgcagcggt cgggctgaac     4920

ggggggttcg tgcacacagc ccagcttgga gcgaacgacc tacaccgaac tgagatacct     4980

acagcgtgag ctatgagaaa gcgccacgct tcccgaaggg agaaaggcgg acaggtatcc     5040

ggtaagcggc agggtcggaa caggagagcg cacgagggag cttccagggg gaaacgcctg     5100

gtatctttat agtcctgtcg ggtttcgcca cctctgactt gagcgtcgat ttttgtgatg     5160

ctcgtcaggg gggcggagcc tatggaaaaa cgccagcaac gcggcctttt tacggttcct     5220

ggccttttgc tggccttttg ctcacatgtt ctttcctgcg ttatcccctg attctgtgga     5280

taaccgtatt accgcctttg agtgagctga taccgctcgc cgcagccgaa cgaccgagcg     5340

cagcgagtca gtgagcgagg aagcggaaga gcgcccaata cgcaaaccgc ctctccccgc     5400

gcgttggccg attcattaat g                                               5421


<210>  13
<211>  8335
<212>  DNA
<213>  Artificial

<220>
<223>  pGG2 plasmid comprising sequences of CMV IE promoter and the 
       sequence coding for mouse m-KL (pGG2-m-KL)

<400>  13
cagcagctgc gcgctcgctc gctcactgag gccgcccggg caaagcccgg gcgtcgggcg       60

acctttggtc gcccggcctc agtgagcgag cgagcgcgca gagagggagt ggccaactcc      120

atcactaggg gttccttgta gttaatgatt aacccgccat gctacttatc tacgtagcca      180

tgctctagac atggctcgac agatctcaat attggccatt agccatatta ttcattggtt      240

atatagcata aatcaatatt ggctattggc cattgcatac gttgtatcta tatcataata      300

tgtacattta tattggctca tgtccaatat gaccgccatg ttggcattga ttattgacta      360

gttattaata gtaatcaatt acggggtcat tagttcatag cccatatatg gagttccgcg      420

ttacataact tacggtaaat ggcccgcctg gctgaccgcc caacgacccc cgcccattga      480

cgtcaataat gacgtatgtt cccatagtaa cgccaatagg gactttccat tgacgtcaat      540

gggtggagta tttacggtaa actgcccact tggcagtaca tcaagtgtat catatgccaa      600

gtccgccccc tattgacgtc aatgacggta aatggcccgc ctggcattat gcccagtaca      660

tgaccttacg ggactttcct acttggcagt acatctacgt attagtcatc gctattacca      720

tggtgatgcg gttttggcag tacaccaatg ggcgtggata gcggtttgac tcacggggat      780

ttccaagtct ccaccccatt gacgtcaatg ggagtttgtt ttggcaccaa aatcaacggg      840

actttccaaa atgtcgtaac aactgcgatc gcccgccccg ttgacgcaaa tgggcggtag      900

gcgtgtacgg tgggaggtct atataagcag agctcgttta gtgaaccgtc agatcactag      960

aagcttgata tcgaattcgc ccttgataat cattgctcgt ggggcggcgg gagcgggggt     1020

gggcaccgcg tagggagggc ggcggggcgc gggcatatag gggcgcggcg cggtgccctc     1080

ccggctcccg cagcatgcta gcccgcgccc ctcctcgccg cccgccgcgg ctggtgctgc     1140

tccgtttgct gttgctgcat ctgctgctgc tcgccctgcg cgcccgctgc ctgagcgctg     1200

agccgggtca gggcgcgcag acctgggctc gcttcgcgcg cgctcctgcc ccagaggccg     1260

ctggcctcct ccacgacacc ttccccgacg gtttcctctg ggcggtaggc agcgccgcct     1320

atcagaccga gggcggctgg cgacagcacg gcaaaggcgc gtccatctgg gacactttca     1380

cccatcactc tggggcggcc ccgtccgact ccccgatcgt cgtggcgccg tcgggtgccc     1440

cgtcgcctcc cctgtcctcc actggagatg tggccagcga tagttacaac aacgtctacc     1500

gcgacacaga ggggctgcgc gaactggggg tcacccacta ccgcttctcc atatcgtggg     1560

cgcgggtgct ccccaatggc accgcgggca ctcccaaccg cgaggggctg cgctactacc     1620

ggcggctgct ggagcggctg cgggagctgg gcgtgcagcc ggtggttacc ctgtaccatt     1680

gggacctgcc acagcgcctg caggacacct atggcggatg ggccaatcgc gccctggccg     1740

accatttcag ggattatgcc gagctctgct tccgccactt cggtggtcag gtcaagtact     1800

ggatcaccat tgacaacccc tacgtggtgg cctggcacgg gtatgccacc gggcgcctgg     1860

ccccgggcgt gaggggcagc tccaggctcg ggtacctggt tgcccacaac ctacttttgg     1920

ctcatgccaa agtctggcat ctctacaaca cctctttccg ccccacacag ggaggccggg     1980

tgtctatcgc cttaagctcc cattggatca atcctcgaag aatgactgac tataatatca     2040

gagaatgcca gaagtctctt gactttgtgc taggctggtt tgccaaaccc atatttattg     2100

atggcgacta cccagagagt atgaagaaca acctctcgtc tcttctgcct gattttactg     2160

aatctgagaa gaggctcatc agaggaactg ctgacttttt tgctctctcc ttcggaccaa     2220

ccttgagctt tcagctattg gaccctaaca tgaagttccg ccaattggag tctcccaacc     2280

tgaggcagct tctgtcttgg atagatctgg aatataacca ccctccaata tttattgtgg     2340

aaaatggctg gtttgtctcg ggaaccacca aaagggatga tgccaaatat atgtattatc     2400

tcaagaagtt cataatggaa accttaaaag caatcagact ggatggggtc gacgtcattg     2460

ggtacaccgc gtggtcgctc atggacggtt tcgagtggca taggggctac agcatccggc     2520

gaggactctt ctacgttgac tttctgagtc aggacaagga gctgttgcca aagtcttcgg     2580

ccttgttcta ccaaaagctg atagaggaca atggctttcc tcctttacct gaaaaccagc     2640

cccttgaagg gacatttccc tgtgactttg cttggggagt tgttgacaac tacgttcaag     2700

tggacactac tctctctcag tttactgacc cgaatgtcta tctgtgggat gtgcatcaca     2760

gtaagaggct tattaaagta gacggggttg tagccaagaa gagaaaacct tactgtgttg     2820

atttctctgc catccggcct cagataacct tacttcgaga aatgcgggtc acccactttc     2880

gcttctccct ggactgggcc ctgatcttgc ctctgggtaa ccagacccaa gtgaaccaca     2940

cggttctgca cttctaccgc tgcatgatca gcgagctggt gcacgccaac atcactccag     3000

tggtggccct gtggcagcca gcagccccgc accaaggcct gccacatgcc cttgcaaaac     3060

atggggcctg ggagaacccg cacactgctc tggcgtttgc agactacgca aacctgtgtt     3120

ttaaagagtt gggtcactgg gtcaatctct ggatcaccat gaacgagcca aacacacgga     3180

acatgaccta tcgtgccggg caccacctcc tgagagccca tgccttggct tggcatctgt     3240

acgatgacaa gtttagggcg gctcagaaag gcaaaatatc catcgccttg caggctgact     3300

ggatagaacc ggcctgccct ttctctcaaa atgacaaaga agtggccgag agagttttgg     3360

aatttgatat aggctggctg gcagagccta tttttggttc cggagattat ccacgtgtga     3420

tgagggactg gctgaaccaa aaaaacaatt ttcttttgcc ctatttcacc gaagatgaaa     3480

aaaagctagt ccggggttcc tttgacttcc tggcggtgag tcattacacc accattctgg     3540

tagactggga aaaggaggat ccgatgaaat acaacgatta cttggaggta caggagatga     3600

ctgacatcac atggctcaac tctcccagtc aggtggcagt ggtgccttgg gggctgcgca     3660

aagtgctcaa ctggctaagg ttcaagtacg gagacctccc gatgtatgtg acagccaatg     3720

gaatcgatga tgacccccac gccgagcaag actcactgag gatctattat attaagaatt     3780

atgtgaatga ggctctgaaa gcctacgtgt tggacgacat caacctttgt ggctactttg     3840

cgtattcact tagtgatcgc tcagctccca agtctggctt ttatcgatat gctgcgaatc     3900

agtttgagcc caaaccatct atgaaacatt acaggaaaat tattgacagc aatggcttcc     3960

tgggttctgg aacactggga aggttttgtc cagaagaata cactgtgtgc accgaatgtg     4020

gattttttca aacccggaag tctttgctgg tcttcatctc gtttcttgtt tttactttta     4080

ttatttctct tgctctcatt tttcactact ccaagaaagg ccagagaagt tataagtaat     4140

gtgaacgtct gcctggccat tcgctttggg atcaagatgt acacgccgtc agccgtttgc     4200

acctctctgt gttgtgagcc gcattccaca catttcgatt ctagagcggc cgcttccctt     4260

tagtgagggt taatgcttcg agcagacatg ataagataca ttgatgagtt tggacaaacc     4320

acaactagaa tgcagtgaaa aaaatgcttt atttgtgaaa tttgtgatgc tattgcttta     4380

tttgtaacca ttataagctg caataaacaa gttaacaaca acaattgcat tcattttatg     4440

tttcaggttc agggggagat gtgggaggtt ttttaaagca agtaaaacct ctacaaatgt     4500

ggtaaaatcc gataagggac tagagcatgg ctacgtagat aagtagcatg gcgggttaat     4560

cattaactac aaggaacccc tagtgatgga gttggccact ccctctctgc gcgctcgctc     4620

gctcactgag gccgggcgac caaaggtcgc ccgacgcccg ggctttgccc gggcggcctc     4680

agtgagcgag cgagcgcgcc agctggcgta atagcgaaga ggcccgcacc gatcgccctt     4740

cccaacagtt gcgcagcctg aatggcgaat ggaattccag acgattgagc gtcaaaatgt     4800

aggtatttcc atgagcgttt ttccgttgca atggctggcg gtaatattgt tctggatatt     4860

accagcaagg ccgatagttt gagttcttct actcaggcaa gtgatgttat tactaatcaa     4920

agaagtattg cgacaacggt taatttgcgt gatggacaga ctcttttact cggtggcctc     4980

actgattata aaaacacttc tcaggattct ggcgtaccgt tcctgtctaa aatcccttta     5040

atcggcctcc tgtttagctc ccgctctgat tctaacgagg aaagcacgtt atacgtgctc     5100

gtcaaagcaa ccatagtacg cgccctgtag cggcgcatta agcgcggcgg gtgtggtggt     5160

tacgcgcagc gtgaccgcta cacttgccag cgccctagcg cccgctcctt tcgctttctt     5220

cccttccttt ctcgccacgt tcgccggctt tccccgtcaa gctctaaatc gggggctccc     5280

tttagggttc cgatttagtg ctttacggca cctcgacccc aaaaaacttg attagggtga     5340

tggttcacgt agtgggccat cgccctgata gacggttttt cgccctttga cgttggagtc     5400

cacgttcttt aatagtggac tcttgttcca aactggaaca acactcaacc ctatctcggt     5460

ctattctttt gatttataag ggattttgcc gatttcggcc tattggttaa aaaatgagct     5520

gatttaacaa aaatttaacg cgaattttaa caaaatatta acgtctacaa tttaaatatt     5580

tgcttataca atcttcctgt ttttggggct tttctgatta tcaaccgggg tacatatgat     5640

tgacatgcta gttttacgat taccgttcat cgattctctt gtttgctcca gactctcagg     5700

caatgacctg atagcctttg tagagacctc tcaaaaatag ctaccctctc cggcatgaat     5760

ttatcagcta gaacggttga atatcatatt gatggtgatt tgactgtctc cggcctttct     5820

cacccgtttg aatctttacc tacacattac tcaggcattg catttaaaat atatgagggt     5880

tctaaaaatt tttatccttg cgttgaaata aaggcttctc ccgcaaaagt attacagggt     5940

cataatgttt ttggtacaac cgatttagct ttatgctctg aggctttatt gcttaatttt     6000

gctaattctt tgccttgcct gtatgattta ttggatgttg gaatcgcctg atgcggtatt     6060

ttctccttac gcatctgtgc ggtatttcac accgcatatg gtgcactctc agtacaatct     6120

gctctgatgc cgcatagtta agccagcccc gacacccgcc aacacccgct gacgcgccct     6180

gacgggcttg tctgctcccg gcatccgctt acagacaagc tgtgaccgtc tccgggagct     6240

gcatgtgtca gaggttttca ccgtcatcac cgaaacgcgc gagacgaaag ggcctcgtga     6300

tacgcctatt tttataggtt aatgtcatga taataatggt ttcttagacg tcaggtggca     6360

cttttcgggg aaatgtgcgc ggaaccccta tttgtttatt tttctaaata cattcaaata     6420

tgtatccgct catgagacaa taaccctgat aaatgcttca ataatattga aaaaggaaga     6480

gtatgagtat tcaacatttc cgtgtcgccc ttattccctt ttttgcggca ttttgccttc     6540

ctgtttttgc tcacccagaa acgctggtga aagtaaaaga tgctgaagat cagttgggtg     6600

cacgagtggg ttacatcgaa ctggatctca acagcggtaa gatccttgag agttttcgcc     6660

ccgaagaacg ttttccaatg atgagcactt ttaaagttct gctatgtggc gcggtattat     6720

cccgtattga cgccgggcaa gagcaactcg gtcgccgcat acactattct cagaatgact     6780

tggttgagta ctcaccagtc acagaaaagc atcttacgga tggcatgaca gtaagagaat     6840

tatgcagtgc tgccataacc atgagtgata acactgcggc caacttactt ctgacaacga     6900

tcggaggacc gaaggagcta accgcttttt tgcacaacat gggggatcat gtaactcgcc     6960

ttgatcgttg ggaaccggag ctgaatgaag ccataccaaa cgacgagcgt gacaccacga     7020

tgcctgtagc aatggcaaca acgttgcgca aactattaac tggcgaacta cttactctag     7080

cttcccggca acaattaata gactggatgg aggcggataa agttgcagga ccacttctgc     7140

gctcggccct tccggctggc tggtttattg ctgataaatc tggagccggt gagcgtgggt     7200

ctcgcggtat cattgcagca ctggggccag atggtaagcc ctcccgtatc gtagttatct     7260

acacgacggg gagtcaggca actatggatg aacgaaatag acagatcgct gagataggtg     7320

cctcactgat taagcattgg taactgtcag accaagttta ctcatatata ctttagattg     7380

atttaaaact tcatttttaa tttaaaagga tctaggtgaa gatccttttt gataatctca     7440

tgaccaaaat cccttaacgt gagttttcgt tccactgagc gtcagacccc gtagaaaaga     7500

tcaaaggatc ttcttgagat cctttttttc tgcgcgtaat ctgctgcttg caaacaaaaa     7560

aaccaccgct accagcggtg gtttgtttgc cggatcaaga gctaccaact ctttttccga     7620

aggtaactgg cttcagcaga gcgcagatac caaatactgt ccttctagtg tagccgtagt     7680

taggccacca cttcaagaac tctgtagcac cgcctacata cctcgctctg ctaatcctgt     7740

taccagtggc tgctgccagt ggcgataagt cgtgtcttac cgggttggac tcaagacgat     7800

agttaccgga taaggcgcag cggtcgggct gaacgggggg ttcgtgcaca cagcccagct     7860

tggagcgaac gacctacacc gaactgagat acctacagcg tgagctatga gaaagcgcca     7920

cgcttcccga agggagaaag gcggacaggt atccggtaag cggcagggtc ggaacaggag     7980

agcgcacgag ggagcttcca gggggaaacg cctggtatct ttatagtcct gtcgggtttc     8040

gccacctctg acttgagcgt cgatttttgt gatgctcgtc aggggggcgg agcctatgga     8100

aaaacgccag caacgcggcc tttttacggt tcctggcctt ttgctggcct tttgctcaca     8160

tgttctttcc tgcgttatcc cctgattctg tggataaccg tattaccgcc tttgagtgag     8220

ctgataccgc tcgccgcagc cgaacgaccg agcgcagcga gtcagtgagc gaggaagcgg     8280

aagagcgccc aatacgcaaa ccgcctctcc ccgcgcgttg gccgattcat taatg          8335


<210>  14
<211>  5640
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic plasmid pUC57-KL (GenScript, USA)

<400>  14
tcgcgcgttt cggtgatgac ggtgaaaacc tctgacacat gcagctcccg gagacggtca       60

cagcttgtct gtaagcggat gccgggagca gacaagcccg tcagggcgcg tcagcgggtg      120

ttggcgggtg tcggggctgg cttaactatg cggcatcaga gcagattgta ctgagagtgc      180

accatatgcg gtgtgaaata ccgcacagat gcgtaaggag aaaataccgc atcaggcgcc      240

attcgccatt caggctgcgc aactgttggg aagggcgatc ggtgcgggcc tcttcgctat      300

tacgccagct ggcgaaaggg ggatgtgctg caaggcgatt aagttgggta acgccagggt      360

tttcccagtc acgacgttgt aaaacgacgg ccagtgaatt cttctagaat gctcgcccgc      420

gcccctcctc gccgcccgcc gcggctggtg ctgctccgtt tgctgttgct gcatctgctg      480

ctgctcgccc tgcgcgcccg ctgcctgagc gctgagccgg gtcagggcgc gcagacctgg      540

gctcgcttcg cgcgcgctcc tgccccagag gccgctggcc tcctccacga caccttcccc      600

gacggtttcc tctgggcggt aggcagcgcc gcctatcaga ccgagggcgg ctggcgacag      660

cacggcaaag gcgcgtccat ctgggacact ttcacccatc actctggggc ggccccgtcc      720

gactccccga tcgtcgtggc gccgtcgggt gccccgtcgc ctcccctgtc ctccactgga      780

gatgtggcca gcgatagtta caacaacgtc taccgcgaca cagaggggct gcgcgaactg      840

ggggtcaccc actaccgctt ctccatatcg tgggcgcggg tgctccccaa tggcaccgcg      900

ggcactccca accgcgaggg gctgcgctac taccggcggc tgctggagcg gctgcgggag      960

ctgggcgtgc agccggtggt taccctgtac cattgggacc tgccacagcg cctgcaggac     1020

acctatggcg gatgggccaa tcgcgccctg gccgaccatt tcagggatta tgccgagctc     1080

tgcttccgcc acttcggtgg tcaggtcaag tactggatca ccattgacaa cccctacgtg     1140

gtggcctggc acgggtatgc caccgggcgc ctggccccgg gcgtgagggg cagctccagg     1200

ctcgggtacc tggttgccca caacctactt ttggctcatg ccaaagtctg gcatctctac     1260

aacacctctt tccgccccac acagggaggc cgggtgtcta tcgccttaag ctcccattgg     1320

atcaatcctc gaagaatgac tgactataat atcagagaat gccagaagtc tcttgacttt     1380

gtgctaggct ggtttgccaa acccatattt attgatggcg actacccaga gagtatgaag     1440

aacaacctct cgtctcttct gcctgatttt actgaatctg agaagaggct catcagagga     1500

actgctgact tttttgctct ctccttcgga ccaaccttga gctttcagct attggaccct     1560

aacatgaagt tccgccaatt ggagtctccc aacctgaggc agcttctgtc ttggatagat     1620

ctggaatata accaccctcc aatatttatt gtggaaaatg gctggtttgt ctcgggaacc     1680

accaaaaggg atgatgccaa atatatgtat tatctcaaga agttcataat ggaaacctta     1740

aaagcaatca gactggatgg ggtcgacgtc attgggtaca ccgcgtggtc gctcatggac     1800

ggtttcgagt ggcatagggg ctacagcatc cggcgaggac tcttctacgt tgactttctg     1860

agtcaggaca aggagctgtt gccaaagtct tcggccttgt tctaccaaaa gctgatagag     1920

gacaatggct ttcctccttt acctgaaaac cagccccttg aagggacatt tccctgtgac     1980

tttgcttggg gagttgttga caactacgtt cagctgagtc ctttgacaaa acccagtgtc     2040

ggcctcttgc ttcctcacta agggcccaga gactgaagct ttacgtagac actactctct     2100

ctcagtttac tgacccgaat gtctatctgt gggatgtgca tcacagtaag aggcttatta     2160

aagtagacgg ggttgtagcc aaggctagca aaccttactg tgttgatttc tctgccatcc     2220

ggcctcagat aaccttactt cgagaaatgc gggtcaccca ctttcgcttc tccctggact     2280

gggcgctgat cttgcctctg ggtaaccaga cccaagtgaa ccacacggtt ctgcacttct     2340

accgctgcat gatcagcgag ctggtgcacg ccaacatcac tccagtggtg gccctgtggc     2400

agccagcagc cccgcaccaa ggcctgccac atgcccttgc aaaacatggg gcctgggaga     2460

acccgcacac tgctctggcg tttgcagact acgcaaacct gtgttttaaa gagttgggtc     2520

actgggtcaa tctctggatc accatgaacg agccaaacac acggaacatg acctatcgtg     2580

ccgggcacca cctcctgaga gcccatgcct tggcttggca tctgtacgat gacaagttta     2640

gggcggctca gaaaggcaaa atatccatcg ccttgcaggc tgactggata gaaccggcct     2700

gccctttctc tcaaaatgac aaagaagtgg ccgagagagt tttggaattt gatataggct     2760

ggctggcaga gcctattttt ggttccggag attatccacg tgtgatgagg gactggctga     2820

accaaaaaaa caattttctt ttgccctatt tcaccgaaga tgaaaaaaag ctagtccggg     2880

gttcctttga cttcctggcg gtgagtcatt acaccaccat tctggtagac tgggaaaagg     2940

aggatccgat gaaatacaac gattacttgg aggtacagga gatgactgac atcacatggc     3000

tcaactctcc cagtcaggtg gcagtggtgc cttgggggct gcgcaaagtg ctcaactggc     3060

taaggttcaa gtacggagac ctcccgatgt atgtgacagc caatggaatc gatgatgacc     3120

cccacgccga gcaagactca ctgaggatct attatattaa gaattatgtg aatgaggctc     3180

tgaaagccta cgtgttggac gacatcaacc tttgtggcta ctttgcgtat tcacttagtg     3240

atcgctcagc tcccaagtct ggcttttatc gatatgctgc gaatcagttt gagcccaaac     3300

catctatgaa acattacagg aaaattattg acagcaatgg cttcctgggt tctggaacac     3360

tgggaaggtt ttgtccagaa gaataagcgg ccgcgcatgc aagcttggcg taatcatggt     3420

catagctgtt tcctgtgtga aattgttatc cgctcacaat tccacacaac atacgagccg     3480

gaagcataaa gtgtaaagcc tggggtgcct aatgagtgag ctaactcaca ttaattgcgt     3540

tgcgctcact gcccgctttc cagtcgggaa acctgtcgtg ccagctgcat taatgaatcg     3600

gccaacgcgc ggggagaggc ggtttgcgta ttgggcgctc ttccgcttcc tcgctcactg     3660

actcgctgcg ctcggtcgtt cggctgcggc gagcggtatc agctcactca aaggcggtaa     3720

tacggttatc cacagaatca ggggataacg caggaaagaa catgtgagca aaaggccagc     3780

aaaaggccag gaaccgtaaa aaggccgcgt tgctggcgtt tttccatagg ctccgccccc     3840

ctgacgagca tcacaaaaat cgacgctcaa gtcagaggtg gcgaaacccg acaggactat     3900

aaagatacca ggcgtttccc cctggaagct ccctcgtgcg ctctcctgtt ccgaccctgc     3960

cgcttaccgg atacctgtcc gcctttctcc cttcgggaag cgtggcgctt tctcatagct     4020

cacgctgtag gtatctcagt tcggtgtagg tcgttcgctc caagctgggc tgtgtgcacg     4080

aaccccccgt tcagcccgac cgctgcgcct tatccggtaa ctatcgtctt gagtccaacc     4140

cggtaagaca cgacttatcg ccactggcag cagccactgg taacaggatt agcagagcga     4200

ggtatgtagg cggtgctaca gagttcttga agtggtggcc taactacggc tacactagaa     4260

gaacagtatt tggtatctgc gctctgctga agccagttac cttcggaaaa agagttggta     4320

gctcttgatc cggcaaacaa accaccgctg gtagcggtgg tttttttgtt tgcaagcagc     4380

agattacgcg cagaaaaaaa ggatctcaag aagatccttt gatcttttct acggggtctg     4440

acgctcagtg gaacgaaaac tcacgttaag ggattttggt catgagatta tcaaaaagga     4500

tcttcaccta gatcctttta aattaaaaat gaagttttaa atcaatctaa agtatatatg     4560

agtaaacttg gtctgacagt taccaatgct taatcagtga ggcacctatc tcagcgatct     4620

gtctatttcg ttcatccata gttgcctgac tccccgtcgt gtagataact acgatacggg     4680

agggcttacc atctggcccc agtgctgcaa tgataccgcg agacccacgc tcaccggctc     4740

cagatttatc agcaataaac cagccagccg gaagggccga gcgcagaagt ggtcctgcaa     4800

ctttatccgc ctccatccag tctattaatt gttgccggga agctagagta agtagttcgc     4860

cagttaatag tttgcgcaac gttgttgcca ttgctacagg catcgtggtg tcacgctcgt     4920

cgtttggtat ggcttcattc agctccggtt cccaacgatc aaggcgagtt acatgatccc     4980

ccatgttgtg caaaaaagcg gttagctcct tcggtcctcc gatcgttgtc agaagtaagt     5040

tggccgcagt gttatcactc atggttatgg cagcactgca taattctctt actgtcatgc     5100

catccgtaag atgcttttct gtgactggtg agtactcaac caagtcattc tgagaatagt     5160

gtatgcggcg accgagttgc tcttgcccgg cgtcaatacg ggataatacc gcgccacata     5220

gcagaacttt aaaagtgctc atcattggaa aacgttcttc ggggcgaaaa ctctcaagga     5280

tcttaccgct gttgagatcc agttcgatgt aacccactcg tgcacccaac tgatcttcag     5340

catcttttac tttcaccagc gtttctgggt gagcaaaaac aggaaggcaa aatgccgcaa     5400

aaaagggaat aagggcgaca cggaaatgtt gaatactcat actcttcctt tttcaatatt     5460

attgaagcat ttatcagggt tattgtctca tgagcggata catatttgaa tgtatttaga     5520

aaaataaaca aataggggtt ccgcgcacat ttccccgaaa agtgccacct gacgtctaag     5580

aaaccattat tatcatgaca ttaacctata aaaataggcg tatcacgagg ccctttcgtc     5640


<210>  15
<211>  5931
<212>  DNA
<213>  Artificial

<220>
<223>  pGG2 plasmid comprising sequences of CMV IE promoter and the 
       sequence coding for mouse s-KL (pGG2-s-KL)

<400>  15
cagcagctgc gcgctcgctc gctcactgag gccgcccggg caaagcccgg gcgtcgggcg       60

acctttggtc gcccggcctc agtgagcgag cgagcgcgca gagagggagt ggccaactcc      120

atcactaggg gttccttgta gttaatgatt aacccgccat gctacttatc tacgtagcca      180

tgctctagaa tgctcgcccg cgcccctcct cgccgcccgc cgcggctggt gctgctccgt      240

ttgctgttgc tgcatctgct gctgctcgcc ctgcgcgccc gctgcctgag cgctgagccg      300

ggtcagggcg cgcagacctg ggctcgcttc gcgcgcgctc ctgccccaga ggccgctggc      360

ctcctccacg acaccttccc cgacggtttc ctctgggcgg taggcagcgc cgcctatcag      420

accgagggcg gctggcgaca gcacggcaaa ggcgcgtcca tctgggacac tttcacccat      480

cactctgggg cggccccgtc cgactccccg atcgtcgtgg cgccgtcggg tgccccgtcg      540

cctcccctgt cctccactgg agatgtggcc agcgatagtt acaacaacgt ctaccgcgac      600

acagaggggc tgcgcgaact gggggtcacc cactaccgct tctccatatc gtgggcgcgg      660

gtgctcccca atggcaccgc gggcactccc aaccgcgagg ggctgcgcta ctaccggcgg      720

ctgctggagc ggctgcggga gctgggcgtg cagccggtgg ttaccctgta ccattgggac      780

ctgccacagc gcctgcagga cacctatggc ggatgggcca atcgcgccct ggccgaccat      840

ttcagggatt atgccgagct ctgcttccgc cacttcggtg gtcaggtcaa gtactggatc      900

accattgaca acccctacgt ggtggcctgg cacgggtatg ccaccgggcg cctggccccg      960

ggcgtgaggg gcagctccag gctcgggtac ctggttgccc acaacctact tttggctcat     1020

gccaaagtct ggcatctcta caacacctct ttccgcccca cacagggagg ccgggtgtct     1080

atcgccttaa gctcccattg gatcaatcct cgaagaatga ctgactataa tatcagagaa     1140

tgccagaagt ctcttgactt tgtgctaggc tggtttgcca aacccatatt tattgatggc     1200

gactacccag agagtatgaa gaacaacctc tcgtctcttc tgcctgattt tactgaatct     1260

gagaagaggc tcatcagagg aactgctgac ttttttgctc tctccttcgg accaaccttg     1320

agctttcagc tattggaccc taacatgaag ttccgccaat tggagtctcc caacctgagg     1380

cagcttctgt cttggataga tctggaatat aaccaccctc caatatttat tgtggaaaat     1440

ggctggtttg tctcgggaac caccaaaagg gatgatgcca aatatatgta ttatctcaag     1500

aagttcataa tggaaacctt aaaagcaatc agactggatg gggtcgacgt cattgggtac     1560

accgcgtggt cgctcatgga cggtttcgag tggcataggg gctacagcat ccggcgagga     1620

ctcttctacg ttgactttct gagtcaggac aaggagctgt tgccaaagtc ttcggccttg     1680

ttctaccaaa agctgataga ggacaatggc tttcctcctt tacctgaaaa ccagcccctt     1740

gaagggacat ttccctgtga ctttgcttgg ggagttgttg acaactacgt tcagctgagt     1800

cctttgacaa aacccagtgt cggcctcttg cttcctcact aagggccgct tccctttagt     1860

gagggttaat gcttcgagca gacatgataa gatacattga tgagtttgga caaaccacaa     1920

ctagaatgca gtgaaaaaaa tgctttattt gtgaaatttg tgatgctatt gctttatttg     1980

taaccattat aagctgcaat aaacaagtta acaacaacaa ttgcattcat tttatgtttc     2040

aggttcaggg ggagatgtgg gaggtttttt aaagcaagta aaacctctac aaatgtggta     2100

aaatccgata agggactaga gcatggctac gtagataagt agcatggcgg gttaatcatt     2160

aactacaagg aacccctagt gatggagttg gccactccct ctctgcgcgc tcgctcgctc     2220

actgaggccg ggcgaccaaa ggtcgcccga cgcccgggct ttgcccgggc ggcctcagtg     2280

agcgagcgag cgcgccagct ggcgtaatag cgaagaggcc cgcaccgatc gcccttccca     2340

acagttgcgc agcctgaatg gcgaatggaa ttccagacga ttgagcgtca aaatgtaggt     2400

atttccatga gcgtttttcc gttgcaatgg ctggcggtaa tattgttctg gatattacca     2460

gcaaggccga tagtttgagt tcttctactc aggcaagtga tgttattact aatcaaagaa     2520

gtattgcgac aacggttaat ttgcgtgatg gacagactct tttactcggt ggcctcactg     2580

attataaaaa cacttctcag gattctggcg taccgttcct gtctaaaatc cctttaatcg     2640

gcctcctgtt tagctcccgc tctgattcta acgaggaaag cacgttatac gtgctcgtca     2700

aagcaaccat agtacgcgcc ctgtagcggc gcattaagcg cggcgggtgt ggtggttacg     2760

cgcagcgtga ccgctacact tgccagcgcc ctagcgcccg ctcctttcgc tttcttccct     2820

tcctttctcg ccacgttcgc cggctttccc cgtcaagctc taaatcgggg gctcccttta     2880

gggttccgat ttagtgcttt acggcacctc gaccccaaaa aacttgatta gggtgatggt     2940

tcacgtagtg ggccatcgcc ctgatagacg gtttttcgcc ctttgacgtt ggagtccacg     3000

ttctttaata gtggactctt gttccaaact ggaacaacac tcaaccctat ctcggtctat     3060

tcttttgatt tataagggat tttgccgatt tcggcctatt ggttaaaaaa tgagctgatt     3120

taacaaaaat ttaacgcgaa ttttaacaaa atattaacgt ctacaattta aatatttgct     3180

tatacaatct tcctgttttt ggggcttttc tgattatcaa ccggggtaca tatgattgac     3240

atgctagttt tacgattacc gttcatcgat tctcttgttt gctccagact ctcaggcaat     3300

gacctgatag cctttgtaga gacctctcaa aaatagctac cctctccggc atgaatttat     3360

cagctagaac ggttgaatat catattgatg gtgatttgac tgtctccggc ctttctcacc     3420

cgtttgaatc tttacctaca cattactcag gcattgcatt taaaatatat gagggttcta     3480

aaaattttta tccttgcgtt gaaataaagg cttctcccgc aaaagtatta cagggtcata     3540

atgtttttgg tacaaccgat ttagctttat gctctgaggc tttattgctt aattttgcta     3600

attctttgcc ttgcctgtat gatttattgg atgttggaat cgcctgatgc ggtattttct     3660

ccttacgcat ctgtgcggta tttcacaccg catatggtgc actctcagta caatctgctc     3720

tgatgccgca tagttaagcc agccccgaca cccgccaaca cccgctgacg cgccctgacg     3780

ggcttgtctg ctcccggcat ccgcttacag acaagctgtg accgtctccg ggagctgcat     3840

gtgtcagagg ttttcaccgt catcaccgaa acgcgcgaga cgaaagggcc tcgtgatacg     3900

cctattttta taggttaatg tcatgataat aatggtttct tagacgtcag gtggcacttt     3960

tcggggaaat gtgcgcggaa cccctatttg tttatttttc taaatacatt caaatatgta     4020

tccgctcatg agacaataac cctgataaat gcttcaataa tattgaaaaa ggaagagtat     4080

gagtattcaa catttccgtg tcgcccttat tccctttttt gcggcatttt gccttcctgt     4140

ttttgctcac ccagaaacgc tggtgaaagt aaaagatgct gaagatcagt tgggtgcacg     4200

agtgggttac atcgaactgg atctcaacag cggtaagatc cttgagagtt ttcgccccga     4260

agaacgtttt ccaatgatga gcacttttaa agttctgcta tgtggcgcgg tattatcccg     4320

tattgacgcc gggcaagagc aactcggtcg ccgcatacac tattctcaga atgacttggt     4380

tgagtactca ccagtcacag aaaagcatct tacggatggc atgacagtaa gagaattatg     4440

cagtgctgcc ataaccatga gtgataacac tgcggccaac ttacttctga caacgatcgg     4500

aggaccgaag gagctaaccg cttttttgca caacatgggg gatcatgtaa ctcgccttga     4560

tcgttgggaa ccggagctga atgaagccat accaaacgac gagcgtgaca ccacgatgcc     4620

tgtagcaatg gcaacaacgt tgcgcaaact attaactggc gaactactta ctctagcttc     4680

ccggcaacaa ttaatagact ggatggaggc ggataaagtt gcaggaccac ttctgcgctc     4740

ggcccttccg gctggctggt ttattgctga taaatctgga gccggtgagc gtgggtctcg     4800

cggtatcatt gcagcactgg ggccagatgg taagccctcc cgtatcgtag ttatctacac     4860

gacggggagt caggcaacta tggatgaacg aaatagacag atcgctgaga taggtgcctc     4920

actgattaag cattggtaac tgtcagacca agtttactca tatatacttt agattgattt     4980

aaaacttcat ttttaattta aaaggatcta ggtgaagatc ctttttgata atctcatgac     5040

caaaatccct taacgtgagt tttcgttcca ctgagcgtca gaccccgtag aaaagatcaa     5100

aggatcttct tgagatcctt tttttctgcg cgtaatctgc tgcttgcaaa caaaaaaacc     5160

accgctacca gcggtggttt gtttgccgga tcaagagcta ccaactcttt ttccgaaggt     5220

aactggcttc agcagagcgc agataccaaa tactgtcctt ctagtgtagc cgtagttagg     5280

ccaccacttc aagaactctg tagcaccgcc tacatacctc gctctgctaa tcctgttacc     5340

agtggctgct gccagtggcg ataagtcgtg tcttaccggg ttggactcaa gacgatagtt     5400

accggataag gcgcagcggt cgggctgaac ggggggttcg tgcacacagc ccagcttgga     5460

gcgaacgacc tacaccgaac tgagatacct acagcgtgag ctatgagaaa gcgccacgct     5520

tcccgaaggg agaaaggcgg acaggtatcc ggtaagcggc agggtcggaa caggagagcg     5580

cacgagggag cttccagggg gaaacgcctg gtatctttat agtcctgtcg ggtttcgcca     5640

cctctgactt gagcgtcgat ttttgtgatg ctcgtcaggg gggcggagcc tatggaaaaa     5700

cgccagcaac gcggcctttt tacggttcct ggccttttgc tggccttttg ctcacatgtt     5760

ctttcctgcg ttatcccctg attctgtgga taaccgtatt accgcctttg agtgagctga     5820

taccgctcgc cgcagccgaa cgaccgagcg cagcgagtca gtgagcgagg aagcggaaga     5880

gcgcccaata cgcaaaccgc ctctccccgc gcgttggccg attcattaat g              5931


<210>  16
<211>  18689
<212>  DNA
<213>  Artificial

<220>
<223>  Plasmid pXX6

<400>  16
ttattttgga ttgaagccaa tatgataatg agggggtgga gtttgtgacg tggcgcgggg       60

cgtgggaacg gggcgggtga cgtagtagtg tggcggaagt gtgatgttgc aagtgtggcg      120

gaacacatgt aagcgacgga tgtggcaaaa gtgacgtttt tggtgtgcgc ggatccacag      180

gacgggtgtg gtcgccatga tcgcgtagtc gatagtggct ccaagtagcg aagcgagcag      240

gactgggcgg cggccaaagc ggtcggacag tgctccgaga acgggtgcgc atagaaattg      300

catcaacgca tatagcgcta gcagcacgcc atagtgactg gcgatgctgt cggaatggac      360

gatatcccgc aagaggcccg gcagtaccgg cataaccaag cctatgccta cagcatccag      420

ggtgacggtg ccgaggatga cgatgagcgc attgttagat ttcatacacg gtgcctgact      480

gcgttagcaa tttaactgtg ataaactacc gcattaaagc ttatcgataa gcttgatatc      540

gaattcctgc agcccggggg atccactagt tctagagcgg ccgccaccgc ggtggagctc      600

caattcgccc tatagtgagt cgtattacgc gcgctcactg gccgtcgttt tacaacgtcg      660

tgactgggaa aaccctggcg ttacccaact taatcgcctt gcagcacatc cccctttcgc      720

cagctggcgt aatagcgaag aggcccgcac cgatcgccct tcccaacagt tgcgcagcct      780

gaatggcgaa tgggacgcgc cctgtagcgg cgcattaagc gcggcgggtg tggtggttac      840

gcgcagcgtg accgctacac ttgccagcgc cctagcgccc gctcctttcg ctttcttccc      900

ttcctttctc gccacgttcg ccggctttcc ccgtcaagct ctaaatcggg ggctcccttt      960

agggttccga tttagtgctt tacggcacct cgaccccaaa aaacttgatt agggtgatgg     1020

ttcacgtagt gggccatcgc cctgatagac ggtttttcgc cctttgacgt tggagtccac     1080

gttctttaat agtggactct tgttccaaac tggaacaaca ctcaacccta tctcggtcta     1140

ttcttttgat ttataaggga ttttgccgat ttcggcctat tggttaaaaa atgagctgat     1200

ttaacaaaaa tttaacgcga attttaacaa aatattaacg cttacaattt aggtggcact     1260

tttcggggaa atgtgcgcgg aacccctatt tgtttatttt tctaaataca ttcaaatatg     1320

tatccgctca tgagacaata accctgataa atgcttcaat aatattgaaa aaggaagagt     1380

atgagtattc aacatttccg tgtcgccctt attccctttt ttgcggcatt ttgccttcct     1440

gtttttgctc acccagaaac gctggtgaaa gtaaaagatg ctgaagatca gttgggtgca     1500

cgagtgggtt acatcgaact ggatctcaac agcggtaaga tccttgagag ttttcgcccc     1560

gaagaacgtt ttccaatgat gagcactttt aaagttctgc tatgtggcgc ggtattatcc     1620

cgtattgacg ccgggcaaga gcaactcggt cgccgcatac actattctca gaatgacttg     1680

gttgagtact caccagtcac agaaaagcat cttacggatg gcatgacagt aagagaatta     1740

tgcagtgctg ccataaccat gagtgataac actgcggcca acttacttct gacaacgatc     1800

ggaggaccga aggagctaac cgcttttttg cacaacatgg gggatcatgt aactcgcctt     1860

gatcgttggg aaccggagct gaatgaagcc ataccaaacg acgagcgtga caccacgatg     1920

cctgtagcaa tggcaacaac gttgcgcaaa ctattaactg gcgaactact tactctagct     1980

tcccggcaac aattaataga ctggatggag gcggataaag ttgcaggacc acttctgcgc     2040

tcggcccttc cggctggctg gtttattgct gataaatctg gagccggtga gcgtgggtct     2100

cgcggtatca ttgcagcact ggggccagat ggtaagccct cccgtatcgt agttatctac     2160

acgacgggga gtcaggcaac tatggatgaa cgaaatagac agatcgctga gataggtgcc     2220

tcactgatta agcattggta actgtcagac caagtttact catatatact ttagattgat     2280

ttaaaacttc atttttaatt taaaaggatc taggtgaaga tcctttttga taatctcatg     2340

accaaaatcc cttaacgtga gttttcgttc cactgagcgt cagaccccgt agaaaagatc     2400

aaaggatctt cttgagatcc tttttttctg cgcgtaatct gctgcttgca aacaaaaaaa     2460

ccaccgctac cagcggtggt ttgtttgccg gatcaagagc taccaactct ttttccgaag     2520

gtaactggct tcagcagagc gcagatacca aatactgtcc ttctagtgta gccgtagtta     2580

ggccaccact tcaagaactc tgtagcaccg cctacatacc tcgctctgct aatcctgtta     2640

ccagtggctg ctgccagtgg cgataagtcg tgtcttaccg ggttggactc aagacgatag     2700

ttaccggata aggcgcagcg gtcgggctga acggggggtt cgtgcacaca gcccagcttg     2760

gagcgaacga cctacaccga actgagatac ctacagcgtg agctatgaga aagcgccacg     2820

cttcccgaag ggagaaaggc ggacaggtat ccggtaagcg gcagggtcgg aacaggagag     2880

cgcacgaggg agcttccagg gggaaacgcc tggtatcttt atagtcctgt cgggtttcgc     2940

cacctctgac ttgagcgtcg atttttgtga tgctcgtcag gggggcggag cctatggaaa     3000

aacgccagca acgcggcctt tttacggttc ctggcctttt gctggccttt tgctcacatg     3060

ttctttcctg cgttatcccc tgattctgtg gataaccgta ttaccgcctt tgagtgagct     3120

gataccgctc gccgcagccg aacgaccgag cgcagcgagt cagtgagcga ggaagcggaa     3180

gagcgcccaa tacgcaaacc gcctctcccc gcgcgttggc cgattcatta atgcagctgg     3240

cacgacaggt ttcccgactg gaaagcgggc agtgagcgca acgcaattaa tgtgagttag     3300

ctcactcatt aggcacccca ggctttacac tttatgcttc cggctcgtat gttgtgtgga     3360

attgtgagcg gataacaatt tcacacagga aacagctatg accatgatta cgccaagcgc     3420

gcaattaacc ctcactaaag ggaacaaaag ctgggtaccg ggccccccct cgaggtcgac     3480

agaagcacca tgtccttggg tccggcctgc tgaatgcgca ggcggtcggc catgccccag     3540

gcttcgtttt gacatcggcg caggtctttg tagtagtctt gcatgagcct ttctaccggc     3600

acttcttctt ctccttcctc ttgtcctgca tctcttgcat ctatcgctgc ggcggcggcg     3660

gagtttggcc gtaggtggcg ccctcttcct cccatgcgtg tgaccccgaa gcccctcatc     3720

ggctgaagca gggctaggtc ggcgacaacg cgctcggcta atatggcctg ctgcacctgc     3780

gtgagggtag actggaagtc atccatgtcc acaaagcggt ggtatgcgcc cgtgttgatg     3840

gtgtaagtgc agttggccat aacggaccag ttaacggtct ggtgacccgg ctgcgagagc     3900

tcggtgtacc tgagacgcga gtaagccctc gagtcaaata cgtagtcgtt gcaagtccgc     3960

accaggtact ggtatcccac caaaaagtgc ggcggcggct ggcggtagag gggccagcgt     4020

agggtggccg gggctccggg ggcgagatct tccaacataa ggcgatgata tccgtagatg     4080

tacctggaca tccaggtgat gccggcggcg gtggtggagg cgcgcggaaa gtcgcggacg     4140

cggttccaga tgttgcgcag cggcaaaaag tgctccatgg tcgggacgct ctggccggtc     4200

aggcgcgcgc aatcgttgac gctctagcgt gcaaaaggag agcctgtaag cgggcactct     4260

tccgtggtct ggtggataaa ttcgcaaggg tatcatggcg gacgaccggg gttcgagccc     4320

cgtatccggc cgtccgccgt gatccatgcg gttaccgccc gcgtgtcgaa cccaggtgtg     4380

cgacgtcaga caacggggga gtgctccttt tggcttcctt ccaggcgcgg cggctgctgc     4440

gctagctttt ttggccactg gccgcgcgca gcgtaagcgg ttaggctgga aagcgaaagc     4500

attaagtggc tcgctccctg tagccggagg gttattttcc aagggttgag tcgcgggacc     4560

cccggttcga gtctcggacc ggccggactg cggcgaacgg gggtttgcct ccccgtcatg     4620

caagaccccg cttgcaaatt cctccggaaa cagggacgag cccctttttt gcttttccca     4680

gatgcatccg gtgctgcggc agatgcgccc ccctcctcag cagcggcaag agcaagagca     4740

gcggcagaca tgcagggcac cctcccctcc tcctaccgcg tcaggagggg cgacatccgc     4800

ggttgacgcg gcagcagatg gtgattacga acccccgcgg cgccgggccc ggcactacct     4860

ggacttggag gagggcgagg gcctggcgcg gctaggagcg ccctctcctg agcggtaccc     4920

aagggtgcag ctgaagcgtg atacgcgtga ggcgtacgtg ccgcggcaga acctgtttcg     4980

cgaccgcgag ggagaggagc ccgaggagat gcgggatcga aagttccacg cagggcgcga     5040

gctgcggcat ggcctgaatc gcgagcggtt gctgcgcgag gaggactttg agcccgacgc     5100

gcgaaccggg attagtcccg cgcgcgcaca cgtggcggcc gccgacctgg taaccgcata     5160

cgagcagacg gtgaaccagg agattaactt tcaaaaaagc tttaacaacc acgtgcgtac     5220

gcttgtggcg cgcgaggagg tggctatagg actgatgcat ctgtgggact ttgtaagcgc     5280

gctggagcaa aacccaaata gcaagccgct catggcgcag ctgttcctta tagtgcagca     5340

cagcagggac aacgaggcat tcagggatgc gctgctaaac atagtagagc ccgagggccg     5400

ctggctgctc gatttgataa acatcctgca gagcatagtg gtgcaggagc gcagcttgag     5460

cctggctgac aaggtggccg ccatcaacta ttccatgctt agcctgggca agttttacgc     5520

ccgcaagata taccataccc cttacgttcc catagacaag gaggtaaaga tcgaggggtt     5580

ctacatgcgc atggcgctga aggtgcttac cttgagcgac gacctgggcg tttatcgcaa     5640

cgagcgcatc cacaaggccg tgagcgtgag ccggcggcgc gagctcagcg accgcgagct     5700

gatgcacagc ctgcaaaggg ccctggctgg cacgggcagc ggcgatagag aggccgagtc     5760

ctactttgac gcgggcgctg acctgcgctg ggccccaagc cgacgcgccc tggaggcagc     5820

tggggccgga cctgggctgg cggtggcacc cgcgcgcgct ggcaacgtcg gcggcgtgga     5880

ggaatatgac gaggacgatg agtacgagcc agaggacggc gagtactaag cggtgatgtt     5940

tctgatcaga tgatgcaaga cgcaacggac ccggcggtgc gggcggcgct gcagagccag     6000

ccgtccggcc ttaactccac ggacgactgg cgccaggtca tggaccgcat catgtcgctg     6060

actgcgcgca atcctgacgc gttccggcag cagccgcagg ccaaccggct ctccgcaatt     6120

ctggaagcgg tggtcccggc gcgcgcaaac cccacgcacg agaaggtgct ggcgatcgta     6180

aacgcgctgg ccgaaaacag ggccatccgg cccgacgagg ccggcctggt ctacgacgcg     6240

ctgcttcagc gcgtggctcg ttacaacagc ggcaacgtgc agaccaacct ggaccggctg     6300

gtgggggatg tgcgcgaggc cgtggcgcag cgtgagcgcg cgcagcagca gggcaacctg     6360

ggctccatgg ttgcactaaa cgccttcctg agtacacagc ccgccaacgt gccgcgggga     6420

caggaggact acaccaactt tgtgagcgca ctgcggctaa tggtgactga gacaccgcaa     6480

agtgaggtgt accagtctgg gccagactat tttttccaga ccagtagaca aggcctgcag     6540

accgtaaacc tgagccaggc tttcaaaaac ttgcaggggc tgtggggggt gcgggctccc     6600

acaggcgacc gcgcgaccgt gtctagcttg ctgacgccca actcgcgcct gttgctgctg     6660

ctaatagcgc ccttcacgga cagtggcagc gtgtcccggg acacatacct aggtcacttg     6720

ctgacactgt accgcgaggc cataggtcag gcgcatgtgg acgagcatac tttccaggag     6780

attacaagtg tcagccgcgc gctggggcag gaggacacgg gcagcctgga ggcaacccta     6840

aactacctgc tgaccaaccg gcggcagaag atcccctcgt tgcacagttt cgcacccttt     6900

ggcgcatccc attctccagt aactttatgt ccatgggcgc actcacagac ctgggccaaa     6960

accttctcta cgccaactcc gcccacgcgc tagacatgac ttttgaggtg gatcccatgg     7020

acgagcccac ccttctttat gttttgtttg aagtctttga cgtggtccgt gtgcaccggc     7080

cgcaccgcgg cgtcatcgaa accgtgtacc tgcgcacgcc cttctcggcc ggcaacgcca     7140

caacataaag aagcaagcaa catcaacaac agctgccgcc atgggctcca gtgagcagga     7200

actgaaagcc attgtcaaag atcttggttg tgggccatat tttttgggca cctatgacaa     7260

gcgctttcca ggctttgttt ctccacacaa gctcgcctgc gccatagtca atacggccgg     7320

tcgcgagact gggggcgtac actggatggc ctttgcctgg aacccgcact caaaaacatg     7380

ctacctcttt gagccctttg gcttttctga ccagcgactc aagcaggttt accagtttga     7440

gtacgagtca ctcctgcgcc gtagcgccat tgcttcttcc cccgaccgct gtataacgct     7500

ggaaaagtcc acccaaagcg tacaggggcc caactcggcc gcctgtggac tattctgctg     7560

catgtttctc cacgcctttg ccaactggcc ccaaactccc atggatcaca accccaccat     7620

gaaccttatt accggggtac ccaactccat gctcaacagt ccccaggtac agcccaccct     7680

gcgtcgcaac caggaacagc tctacagctt cctggagcgc cactcgccct acttccgcag     7740

ccacagtgcg cagattagga gcgccacttc tttttgtcac ttgaaaaaca tgtaaaaata     7800

atgtactaga gacactttca ataaaggcaa atgcttttat ttgtacactc tcgggtgatt     7860

atttaccccc acccttgccg tctgcgccgt ttaaaaatca aaggggttct gccgcgcatc     7920

gctatgcgcc actggcaggg acacgttgcg atactggtgt ttagtgctcc acttaaactc     7980

aggcacaacc atccgcggca gctcggtgaa gttttcactc cacaggctgc gcaccatcac     8040

caacgcgttt agcaggtcgg gcgccgatat cttgaagtcg cagttggggc ctccgccctg     8100

cgcgcgcgag ttgcgataca cagggttgca gcactggaac actatcagcg ccgggtggtg     8160

cacgctggcc agcacgctct tgtcggagat cagatccgcg tccaggtcct ccgcgttgct     8220

cagggcgaac ggagtcaact ttggtagctg ccttcccaaa aagggcgcgt gcccaggctt     8280

tgagttgcac tcgcaccgta gtggcatcaa aaggtgaccg tgcccggtct gggcgttagg     8340

atacagcgcc tgcataaaag ccttgatctg cttaaaagcc acctgagcct ttgcgccttc     8400

agagaagaac atgccgcaag acttgccgga aaactgattg gccggacagg ccgcgtcgtg     8460

cacgcagcac cttgcgtcgg tgttggagat ctgcaccaca tttcggcccc accggttctt     8520

cacgatcttg gccttgctag actgctcctt cagcgcgcgc tgcccgtttt cgctcgtcac     8580

atccatttca atcacgtgct ccttatttat cataatgctt ccgtgtagac acttaagctc     8640

gccttcgatc tcagcgcagc ggtgcagcca caacgcgcag cccgtgggct cgtgatgctt     8700

gtaggtcacc tctgcaaacg actgcaggta cgcctgcagg aatcgcccca tcatcgtcac     8760

aaaggtcttg ttgctggtga aggtcagctg caacccgcgg tgctcctcgt tcagccaggt     8820

cttgcatacg gccgccagag cttccacttg gtcaggcagt agtttgaagt tcgcctttag     8880

atcgttatcc acgtggtact tgtccatcag cgcgcgcgca gcctccatgc ccttctccca     8940

cgcagacacg atcggcacac tcagcgggtt catcaccgta atttcacttt ccgcttcgct     9000

gggctcttcc tcttcctctt gcgtccgcat accacgcgcc actgggtcgt cttcattcag     9060

ccgccgcact gtgcgcttac ctcctttgcc atgcttgatt agcaccggtg ggttgctgaa     9120

acccaccatt tgtagcgcca catcttctct ttcttcctcg ctgtccacga ttacctctgg     9180

tgatggcggg cgctcgggct tgggagaagg gcgcttcttt ttcttcttgg gcgcaatggc     9240

caaatccgcc gccgaggtcg atggccgcgg gctgggtgtg cgcggcacca gcgcgtcttg     9300

tgatgagtct tcctcgtcct cggactcgat acgccgcctc atccgctttt ttgggggcgc     9360

ccggggaggc ggcggcgacg gggacgggga cgacacgtcc tccatggttg ggggacgtcg     9420

cgccgcaccg cgtccgcgct cgggggtggt ttcgcgctgc tcctcttccc gactggccat     9480

ttccttctcc tataggcaga aaaagatcat ggagtcagtc gagaagaagg acagcctaac     9540

cgccccctct gagttcgcca ccaccgcctc caccgatgcc gccaacgcgc ctaccacctt     9600

ccccgtcgag gcacccccgc ttgaggagga ggaagtgatt atcgagcagg acccaggttt     9660

tgtaagcgaa gacgacgagg accgctcagt accaacagag gataaaaagc aagaccagga     9720

caacgcagag gcaaacgagg aacaagtcgg gcggggggac gaaaggcatg gcgactacct     9780

agatgtggga gacgacgtgc tgttgaagca tctgcagcgc cagtgcgcca ttatctgcga     9840

cgcgttgcaa gagcgcagcg atgtgcccct cgccatagcg gatgtcagcc ttgcctacga     9900

acgccaccta ttctcaccgc gcgtaccccc caaacgccaa gaaaacggca catgcgagcc     9960

caacccgcgc ctcaacttct accccgtatt tgccgtgcca gaggtgcttg ccacctatca    10020

catctttttc caaaactgca agatacccct atcctgccgt gccaaccgca gccgagcgga    10080

caagcagctg gccttgcggc agggcgctgt catacctgat atcgcctcgc tcaacgaagt    10140

gccaaaaatc tttgagggtc ttggacgcga cgagaagcgc gcggcaaacg ctctgcaaca    10200

ggaaaacagc gaaaatgaaa gtcactctgg agtgttggtg gaactcgagg gtgacaacgc    10260

gcgcctagcc gtactaaaac gcagcatcga ggtcacccac tttgcctacc cggcacttaa    10320

cctacccccc aaggtcatga gcacagtcat gagtgagctg atcgtgcgcc gtgcgcagcc    10380

cctggagagg gatgcaaatt tgcaagaaca aacagaggag ggcctacccg cagttggcga    10440

cgagcagcta gcgcgctggc ttcaaacgcg cgagcctgcc gacttggagg agcgacgcaa    10500

actaatgatg gccgcagtgc tcgttaccgt ggagcttgag tgcatgcagc ggttctttgc    10560

tgacccggag atgcagcgca agctagagga aacattgcac tacacctttc gacagggcta    10620

cgtacgccag gcctgcaaga tctccaacgt ggagctctgc aacctggtct cctaccttgg    10680

aattttgcac gaaaaccgcc ttgggcaaaa cgtgcttcat tccacgctca agggcgaggc    10740

gcgccgcgac tacgtccgcg actgcgttta cttatttcta tgctacacct ggcagacggc    10800

catgggcgtt tggcagcagt gcttggagga gtgcaacctc aaggagctgc agaaactgct    10860

aaagcaaaac ttgaaggacc tatggacggc cttcaacgag cgctccgtgg ccgcgcacct    10920

ggcggacatc attttccccg aacgcctgct taaaaccctg caacagggtc tgccagactt    10980

caccagtcaa agcatgttgc agaactttag gaactttatc ctagagcgct caggaatctt    11040

gcccgccacc tgctgtgcac ttcctagcga ctttgtgccc attaagtacc gcgaatgccc    11100

tccgccgctt tggggccact gctaccttct gcagctagcc aactaccttg cctaccactc    11160

tgacataatg gaagacgtga gcggtgacgg tctactggag tgtcactgtc gctgcaacct    11220

atgcaccccg caccgctccc tggtttgcaa ttcgcagctg cttaacgaaa gtcaaattat    11280

cggtaccttt gagctgcagg gtccctcgcc tgacgaaaag tccgcggctc cggggttgaa    11340

actcactccg gggctgtgga cgtcggctta ccttcgcaaa tttgtacctg aggactacca    11400

cgcccacgag attaggttct acgaagacca atcccgcccg ccaaatgcgg agcttaccgc    11460

ctgcgtcatt acccagggcc acattcttgg ccaattgcaa gccatcaaca aagcccgcca    11520

agagtttctg ctacgaaagg gacggggggt ttacttggac ccccagtccg gcgaggagct    11580

caacccaatc cccccgccgc cgcagcccta tcagcagcag ccgcgggccc ttgcttccca    11640

ggatggcacc caaaaagaag ctgcagctgc cgccgccacc cacggacgag gaggaatact    11700

gggacagtca ggcagaggag gttttggacg aggaggagga ggacatgatg gaagactggg    11760

agagcctaga cgaggaagct tccgaggtcg aagaggtgtc agacgaaaca ccgtcaccct    11820

cggtcgcatt cccctcgccg gcgccccaga aatcggcaac cggttccagc atggctacaa    11880

cctccgctcc tcaggcgccg ccggcactgc ccgttcgccg acccaaccgt agatgggaca    11940

ccactggaac cagggccggt aagtccaagc agccgccgcc gttagcccaa gagcaacaac    12000

agcgccaagg ctaccgctca tggcgcgggc acaagaacgc catagttgct tgcttgcaag    12060

actgtggggg caacatctcc ttcgcccgcc gctttcttct ctaccatcac ggcgtggcct    12120

tcccccgtaa catcctgcat tactaccgtc atctctacag cccatactgc accggcggca    12180

gcggcagcgg cagcaacagc agcggccaca cagaagcaaa ggcgaccgga tagcaagact    12240

ctgacaaagc ccaagaaatc cacagcggcg gcagcagcag gaggaggagc gctgcgtctg    12300

gcgcccaacg aacccgtatc gacccgcgag cttagaaaca ggatttttcc cactctgtat    12360

gctatatttc aacagagcag gggccaagaa caagagctga aaataaaaaa caggtctctg    12420

cgatccctca cccgcagctg cctgtatcac aaaagcgaag atcagcttcg gcgcacgctg    12480

gaagacgcgg aggctctctt cagtaaatac tgcgcgctga ctcttaagga ctagtttcgc    12540

gccctttctc aaatttaagc gcgaaaacta cgtcatctcc agcggccaca cccggcgcca    12600

gcacctgtcg tcagcgccat tatgagcaag gaaattccca cgccctacat gtggagttac    12660

cagccacaaa tgggacttgc ggctggagct gcccaagact actcaacccg aataaactac    12720

atgagcgcgg gaccccacat gatatcccgg gtcaacggaa tccgcgccca ccgaaaccga    12780

attctcttgg aacaggcggc tattaccacc acacctcgta ataaccttaa tccccgtagt    12840

tggcccgctg ccctggtgta ccaggaaagt cccgctccca ccactgtggt acttcccaga    12900

gacgcccagg ccgaagttca gatgactaac tcaggggcgc agcttgcggg cggctttcgt    12960

cacagggtgc ggtcgcccgg gcagggtata actcacctga caatcagagg gcgaggtatt    13020

cagctcaacg acgagtcggt gagctcctcg cttggtctcc gtccggacgg gacatttcag    13080

atcggcggcg ccggccgtcc ttcattcacg cctcgtcagg caatcctaac tctgcagacc    13140

tcgtcctctg agccgcgctc tggaggcatt ggaactctgc aatttattga ggagtttgtg    13200

ccatcggtct actttaaccc cttctcggga cctcccggcc actatccgga tcaatttatt    13260

cctaactttg acgcggtaaa ggactcggcg gacggctacg actgaatgtt aagtggagag    13320

gcagagcaac tgcgcctgaa acacctggtc cactgtcgcc gccacaagtg ctttgcccgc    13380

gactccggtg agttttgcta ctttgaattg cccgaggatc atatcgaggg cccggcgcac    13440

ggcgtccggc ttaccgccca gggagagctt gcccgtagcc tgattcggga gtttacccag    13500

cgccccctgc tagttgagcg ggacagggga ccctgtgttc tcactgtgat ttgcaactgt    13560

cctaaccttg gattacatca accctttaac taataaaaaa aaataataaa gcatcactta    13620

cttaaaatca gttagcaaat ttctgtccag tttattcagc agcacctcct tgccctcctc    13680

ccagctctgg tattgcagct tcctcctggc tgcaaacttt ctccacaatc taaatggaat    13740

gtcagtttcc tcctgttcct gtccatccgc acccactatc ttcatgttgt tgcagatgaa    13800

gcgcgcaaga ccgtctgaag ataccttcaa ccccgtgtat ccatatgaca cggaaaccgg    13860

tcctccaact gtgccttttc ttactcctcc ctttgtatcc cccaatgggt ttcaagagag    13920

tccccctggg gtactctctt tgcgcctatc cgaacctcta gttacctcca atggcatgct    13980

tgcgctcaaa atgggcaacg gcctctctct ggacgaggcc ggcaacctta cctcccaaaa    14040

tgtaaccact gtgagcccac ctctcaaaaa aaccaagtca aacataaacc tggaaatatc    14100

tgcacccctc acagttacct cagaagccct aactgtggct gccgccgcac ctctaatggt    14160

cgcgggcaac acactcacca tgcaatcaca ggccccgcta accgtgcacg actccaaact    14220

tagcattgcc acccaaggac ccctcacagt gtcagaagga aagctagccc tgcaaacatc    14280

aggccccctc accaccaccg atagcagtac ccttactatc actgcctcac cccctctaac    14340

tactgccact ggtagcttgg gcattgactt gaaagagccc atttatacac aaaatggaaa    14400

actaggacta aagtacgggg ctcctttgca tgtaacagac gacctaaaca ctttgaccgt    14460

agcaactggt ccaggtgtga ctattaataa tacttccttg caaactaaag ttactggagc    14520

cttgggtttt gattcacaag gcaatatgca acttaatgta gcaggaggac taaggattga    14580

ttctcaaaac agacgcctta tacttgatgt tagttatccg tttgatgctc aaaaccaact    14640

aaatctaaga ctaggacagg gccctctttt tataaactca gcccacaact tggatattaa    14700

ctacaacaaa ggcctttact tgtttacagc ttcaaacaat tccaaaaagc ttgaggttaa    14760

cctaagcact gccaaggggt tgatgtttga cgctacagcc atagccatta atgcaggaga    14820

tgggcttgaa tttggttcac ctaatgcacc aaacacaaat cccctcaaaa caaaaattgg    14880

ccatggccta gaatttgatt caaacaaggc tatggttcct aaactaggaa ctggccttag    14940

ttttgacagc acaggtgcca ttacagtagg aaacaaaaat aatgataagc taactttgtg    15000

gaccacacca gctccatctc ctaactgtag actaaatgca gagaaagatg ctaaactcac    15060

tttggtctta acaaaatgtg gcagtcaaat acttgctaca gtttcagttt tggctgttaa    15120

aggcagtttg gctccaatat ctggaacagt tcaaagtgct catcttatta taagatttga    15180

cgaaaatgga gtgctactaa acaattcctt cctggaccca gaatattgga actttagaaa    15240

tggagatctt actgaaggca cagcctatac aaacgctgtt ggatttatgc ctaacctatc    15300

agcttatcca aaatctcacg gtaaaactgc caaaagtaac attgtcagtc aagtttactt    15360

aaacggagac aaaactaaac ctgtaacact aaccattaca ctaaacggta cacaggaaac    15420

aggagacaca actccaagtg catactctat gtcattttca tgggactggt ctggccacaa    15480

ctacattaat gaaatatttg ccacatcctc ttacactttt tcatacattg cccaagaata    15540

aagaatcgtt tgtgttatgt ttcaacgtgt ttatttttca attgcagaaa atttcaagtc    15600

atttttcatt cagtagtata gccccaccac cacatagctt atacagatca ccgtacctta    15660

atcaaactca cagaacccta gtattcaacc tgccacctcc ctcccaacac acagagtaca    15720

cagtcctttc tccccggctg gccttaaaaa gcatcatatc atgggtaaca gacatattct    15780

taggtgttat attccacacg gtttcctgtc gagccaaacg ctcatcagtg atattaataa    15840

actccccggg cagctcactt aagttcatgt cgctgtccag ctgctgagcc acaggctgct    15900

gtccaacttg cggttgctta acgggcggcg aaggagaagt ccacgcctac atgggggtag    15960

agtcataatc gtgcatcagg atagggcggt ggtgctgcag cagcgcgcga ataaactgct    16020

gccgccgccg ctccgtcctg caggaataca acatggcagt ggtctcctca gcgatgattc    16080

gcaccgcccg cagcataagg cgccttgtcc tccgggcaca gcagcgcacc ctgatctcac    16140

ttaaatcagc acagtaactg cagcacagca ccacaatatt gttcaaaatc ccacagtgca    16200

aggcgctgta tccaaagctc atggcgggga ccacagaacc cacgtggcca tcataccaca    16260

agcgcaggta gattaagtgg cgacccctca taaacacgct ggacataaac attacctctt    16320

ttggcatgtt gtaattcacc acctcccggt accatataaa cctctgatta aacatggcgc    16380

catccaccac catcctaaac cagctggcca aaacctgccc gccggctata cactgcaggg    16440

aaccgggact ggaacaatga cagtggagag cccaggactc gtaaccatgg atcatcatgc    16500

tcgtcatgat atcaatgttg gcacaacaca ggcacacgtg catacacttc ctcaggatta    16560

caagctcctc ccgcgttaga accatatccc agggaacaac ccattcctga atcagcgtaa    16620

atcccacact gcagggaaga cctcgcacgt aactcacgtt gtgcattgtc aaagtgttac    16680

attcgggcag cagcggatga tcctccagta tggtagcgcg ggtttctgtc tcaaaaggag    16740

gtagacgatc cctactgtac ggagtgcgcc gagacaaccg agatcgtgtt ggtcgtagtg    16800

tcatgccaaa tggaacgccg gacgtagtca tatttcctga agcaaaacca ggtgcgggcg    16860

tgacaaacag atctgcgtct ccggtctcgc cgcttagatc gctctgtgta gtagttgtag    16920

tatatccact ctctcaaagc atccaggcgc cccctggctt cgggttctat gtaaactcct    16980

tcatgcgccg ctgccctgat aacatccacc accgcagaat aagccacacc cagccaacct    17040

acacattcgt tctgcgagtc acacacggga ggagcgggaa gagctggaag aaccatgttt    17100

ttttttttat tccaaaagat tatccaaaac ctcaaaatga agatctatta agtgaacgcg    17160

ctcccctccg gtggcgtggt caaactctac agccaaagaa cagataatgg catttgtaag    17220

atgttgcaca atggcttcca aaaggcaaac ggccctcacg tccaagtgga cgtaaaggct    17280

aaacccttca gggtgaatct cctctataaa cattccagca ccttcaacca tgcccaaata    17340

attctcatct cgccaccttc tcaatatatc tctaagcaaa tcccgaatat taagtccggc    17400

cattgtaaaa atctgctcca gagcgccctc caccttcagc ctcaagcagc gaatcatgat    17460

tgcaaaaatt caggttcctc acagacctgt ataagattca aaagcggaac attaacaaaa    17520

ataccgcgat cccgtaggtc ccttcgcagg gccagctgaa cataatcgtg caggtctgca    17580

cggaccagcg cggccacttc cccgccagga accttgacaa aagaacccac actgattatg    17640

acacgcatac tcggagctat gctaaccagc gtagccccga tgtaagcttt gttgcatggg    17700

cggcgatata aaatgcaagg tgctgctcaa aaaatcaggc aaagcctcgc gcaaaaaaga    17760

aagcacatcg tagtcatgct catgcagata aaggcaggta agctccggaa ccaccacaga    17820

aaaagacacc atttttctct caaacatgtc tgcgggtttc tgcataaaca caaaataaaa    17880

taacaaaaaa acatttaaac attagaagcc tgtcttacaa caggaaaaac aacccttata    17940

agcataagac ggactacggc catgccggcg tgaccgtaaa aaaactggtc accgtgatta    18000

aaaagcacca ccgacagctc ctcggtcatg tccggagtca taatgtaaga ctcggtaaac    18060

acatcaggtt gattcatcgg tcagtgctaa aaagcgaccg aaatagcccg ggggaataca    18120

tacccgcagg cgtagagaca acattacagc ccccatagga ggtataacaa aattaatagg    18180

agagaaaaac acataaacac ctgaaaaacc ctcctgccta ggcaaaatag caccctcccg    18240

ctccagaaca acatacagcg cttcacagcg gcagcctaac agtcagcctt accagtaaaa    18300

aagaaaacct attaaaaaaa caccactcga cacggcacca gctcaatcag tcacagtgta    18360

aaaaagggcc aagtgcagag cgagtatata taggactaaa aaatgacgta acggttaaag    18420

tccacaaaaa acacccagaa aaccgcacgc gaacctacgc ccagaaacga aagccaaaaa    18480

acccacaact tcctcaaatc gtcacttccg ttttcccacg ttacgtaact tcccatttta    18540

agaaaactac aattcccaac acatacaagt tactccgccc taaaacctac gtcacccgcc    18600

ccgttcccac gccccgcgcc acgtcacaaa ctccaccccc tcattatcat attggcttca    18660

atccaaaata aggtatatta ttgatgatg                                      18689


<210>  17
<211>  7335
<212>  DNA
<213>  Artificial

<220>
<223>  Plasmid pREp2Cap10

<400>  17
gattaaggtc cccagcgacc ttgacgagca tctgcccggc atttctgaca gctttgtgaa       60

ctgggtggcc gagaaggaat gggagttgcc gccagattct gacatggatc tgaatctgat      120

tgagcaggca cccctgaccg tggccgagaa gctgcagcgc gactttctga cggaatggcg      180

ccgtgtgagt aaggccccgg aggctctttt ctttgtgcaa tttgagaagg gagagagcta      240

cttccacatg cacgtgctcg tggaaaccac cggggtgaaa tccatggttt tgggacgttt      300

cctgagtcag attcgcgaaa aactgattca gagaatttac cgcgggatcg agccgacttt      360

gccaaactgg ttcgcggtca caaagaccag aaatggcgcc ggaggcggga acaaggtggt      420

ggatgagtgc tacatcccca attacttgct ccccaaaacc cagcctgagc tccagtgggc      480

gtggactaat atggaacagt atttaagcgc ctgtttgaat ctcacggagc gtaaacggtt      540

ggtggcgcag catctgacgc acgtgtcgca gacgcaggag cagaacaaag agaatcagaa      600

tcccaattct gatgcgccgg tgatcagatc aaaaacttca gccaggtaca tggagctggt      660

cgggtggctc gtggacaagg ggattacctc ggagaagcag tggatccagg aggaccaggc      720

ctcatacatc tccttcaatg cggcctccaa ctcgcggtcc caaatcaagg ctgccttgga      780

caatgcggga aagattatga gcctgactaa aaccgccccc gactacctgg tgggccagca      840

gcccgtggag gacatttcca gcaatcggat ttataaaatt ttggaactaa acgggtacga      900

tccccaatat gcggcttccg tctttctggg atgggccacg aaaaagttcg gcaagaggaa      960

caccatctgg ctgtttgggc ctgcaactac cgggaagacc aacatcgcgg aggccatagc     1020

ccacactgtg cccttctacg ggtgcgtaaa ctggaccaat gagaactttc ccttcaacga     1080

ctgtgtcgac aagatggtga tctggtggga ggaggggaag atgaccgcca aggtcgtgga     1140

gtcggccaaa gccattctcg gaggaagcaa ggtgcgcgtg gaccagaaat gcaagtcctc     1200

ggcccagata gacccgactc ccgtgatcgt cacctccaac accaacatgt gcgccgtgat     1260

tgacgggaac tcaacgacct tcgaacacca gcagccgttg caagaccgga tgttcaaatt     1320

tgaactcacc cgccgtctgg atcatgactt tgggaaggtc accaagcagg aagtcaaaga     1380

ctttttccgg tgggcaaagg atcacgtggt tgaggtggag catgaattct acgtcaaaaa     1440

gggtggagcc aagaaaagac ccgcccccag tgacgcagat ataagtgagc ccaaacgggt     1500

gcgcgagtca gttgcgcagc catcgacgtc agacgcggaa gcttcgatca actacgcaga     1560

caggtaccaa aacaaatgtt ctcgtcacgt gggcatgaat ctgatgctgt ttccctgcag     1620

acaatgcgag agaatgaatc agaattcaaa tatctgcttc actcacggac agaaagactg     1680

tttagagtgc tttcccgtgt cagaatctca acccgtttct gtcgtcaaaa aggcgtatca     1740

gaaactgtgc tacattcatc atatcatggg aaaggtgcca gacgcttgca ctgcctgcga     1800

tctggtcaat gtggatttgg atgactgcat ctttgaacaa taaatgattt aaatcaggta     1860

tggctgccga tggttatctt ccagattggc tcgaggacaa cctctctgag ggcattcgcg     1920

agtggtggga cttgaaacct ggagccccga aacccaaagc caaccagcaa aagcaggacg     1980

acggccgggg tctggtgctt cctggctaca agtacctcgg acccttcaac ggactcgaca     2040

agggggagcc cgtcaacgcg gcggacgcag cggccctcga gcacgacaag gcctacgacc     2100

agcagctcaa agcgggtgac aatccgtacc tgcggtataa ccacgccgac gccgagtttc     2160

aggagcgtct gcaagaagat acgtcttttg ggggcaacct cgggcgagca gtcttccagg     2220

ccaagaagcg ggttctcgaa cctctcggtc tggttgagga aggcgctaag acggctcctg     2280

gaaagaagag accggtagag ccatcacccc agcgttctcc agactcctct acgggcatcg     2340

gcaagaaagg ccagcagccc gcgaaaaaga gactcaactt tgggcagact ggcgactcag     2400

agtcagtgcc cgaccctcaa ccaatcggag aaccccccgc aggcccctct ggtctgggat     2460

ctggtacaat ggctgcaggc ggtggcgctc caatggcaga caataacgaa ggcgccgacg     2520

gagtgggtag ttcctcagga aattggcatt gcgattccac atggctgggc gacagagtca     2580

tcaccaccag cacccgaacc tgggccctcc ccacctacaa caaccacctc tacaagcaaa     2640

tctccaacgg gacttcggga ggaagcacca acgacaacac ctacttcggc tacagcaccc     2700

cctgggggta ttttgacttt aacagattcc actgccactt ctcaccacgt gactggcagc     2760

gactcatcaa caacaactgg ggattccggc ccaagagact caacttcaag ctcttcaaca     2820

tccaggtcaa ggaggtcacg cagaatgaag gcaccaagac catcgccaat aaccttacca     2880

gcacgattca ggtctttacg gactcggaat accagctccc gtacgtcctc ggctctgcgc     2940

accagggctg cctgcctccg ttcccggcgg acgtcttcat gattcctcag tacgggtacc     3000

tgactctgaa caatggcagt caggccgtgg gccgttcctc cttctactgc ctggagtact     3060

ttccttctca aatgctgaga acgggcaaca actttgagtt cagctaccag tttgaggacg     3120

tgccttttca cagcagctac gcgcacagcc aaagcctgga ccggctgatg aaccccctca     3180

tcgaccagta cctgtactac ctgtctcgga ctcagtccac gggaggtacc gcaggaactc     3240

agcagttgct attttctcag gccgggccta ataacatgtc ggctcaggcc aaaaactggc     3300

tacccgggcc ctgctaccgg cagcaacgcg tctccacgac actgtcgcaa aataacaaca     3360

gcaactttgc ctggaccggt gccaccaagt atcatctgaa tggcagagac tctctggtaa     3420

atcccggtgt cgctatggca acccacaagg acgacgaaga gcgatttttt ccgtccagcg     3480

gagtcttaat gtttgggaaa cagggagctg gaaaagacaa cgtggactat agcagcgtta     3540

tgctaaccag tgaggaagaa attaaaacca ccaacccagt ggccacagaa cagtacggcg     3600

tggtggccga taacctgcaa cagcaaaacg ccgctcctat tgtaggggcc gtcaacagtc     3660

aaggagcctt acctggcatg gtctggcaga accgggacgt gtacctgcag ggtcctatct     3720

gggccaagat tcctcacacg gacggaaact ttcatccctc gccgctgatg ggaggctttg     3780

gactgaaaca cccgcctcct cagatcctga ttaagaatac acctgttccc gcggatcctc     3840

caactacctt cagtcaagct aagctggcgt cgttcatcac gcagtacagc accggacagg     3900

tcagcgtgga aattgaatgg gagctgcaga aagaaaacag caaacgctgg aacccagaga     3960

ttcaatacac ttccaactac tacaaatcta caaatgtgga ctttgctgtt aacacagatg     4020

gcacttattc tgagcctcgc cccatcggca cccgttacct cacccgtaat ctgtaattgc     4080

ttgttaatca ataaaccggt tgattcgttt cagttgaact ttggtctctg catatggcga     4140

attcgtttaa acctgcagga ctagagtcct gtattagagg tcacgtgagt gttttgcgac     4200

attttgcgac accatgtggt cacgctgggt atttaagccc gagtgagcac gcagggtctc     4260

cattttgaag cgggaggttt gaacgcgcag ccgccaagcc gaattctgca gatatccatc     4320

acactggcgg ccgctcgact agagcggccg ccaccgcggt ggagctccag cttttgttcc     4380

ctttagtgag ggttaattgc gcgcttggcg taatcatggt catagctgtt tcctgtgtga     4440

aattgttatc cgctcacaat tccacacaac atacgagccg gaagcataaa gtgtaaagcc     4500

tggggtgcct aatgagtgag ctaactcaca ttaattgcgt tgcgctcact gcccgctttc     4560

cagtcgggaa acctgtcgtg ccagctgcat taatgaatcg gccaacgcgc ggggagaggc     4620

ggtttgcgta ttgggcgctc ttccgcttcc tcgctcactg actcgctgcg ctcggtcgtt     4680

cggctgcggc gagcggtatc agctcactca aaggcggtaa tacggttatc cacagaatca     4740

ggggataacg caggaaagaa catgtgagca aaaggccagc aaaaggccag gaaccgtaaa     4800

aaggccgcgt tgctggcgtt tttccatagg ctccgccccc ctgacgagca tcacaaaaat     4860

cgacgctcaa gtcagaggtg gcgaaacccg acaggactat aaagatacca ggcgtttccc     4920

cctggaagct ccctcgtgcg ctctcctgtt ccgaccctgc cgcttaccgg atacctgtcc     4980

gcctttctcc cttcgggaag cgtggcgctt tctcatagct cacgctgtag gtatctcagt     5040

tcggtgtagg tcgttcgctc caagctgggc tgtgtgcacg aaccccccgt tcagcccgac     5100

cgctgcgcct tatccggtaa ctatcgtctt gagtccaacc cggtaagaca cgacttatcg     5160

ccactggcag cagccactgg taacaggatt agcagagcga ggtatgtagg cggtgctaca     5220

gagttcttga agtggtggcc taactacggc tacactagaa gaacagtatt tggtatctgc     5280

gctctgctga agccagttac cttcggaaaa agagttggta gctcttgatc cggcaaacaa     5340

accaccgctg gtagcggtgg tttttttgtt tgcaagcagc agattacgcg cagaaaaaaa     5400

ggatctcaag aagatccttt gatcttttct acggggtctg acgctcagtg gaacgaaaac     5460

tcacgttaag ggattttggt catgagatta tcaaaaagga tcttcaccta gatcctttta     5520

aattaaaaat gaagttttaa atcaatctaa agtatatatg agtaaacttg gtctgacagt     5580

taccaatgct taatcagtga ggcacctatc tcagcgatct gtctatttcg ttcatccata     5640

gttgcctgac tccccgtcgt gtagataact acgatacggg agggcttacc atctggcccc     5700

agtgctgcaa tgataccgcg agacccacgc tcaccggctc cagatttatc agcaataaac     5760

cagccagccg gaagggccga gcgcagaagt ggtcctgcaa ctttatccgc ctccatccag     5820

tctattaatt gttgccggga agctagagta agtagttcgc cagttaatag tttgcgcaac     5880

gttgttgcca ttgctacagg catcgtggtg tcacgctcgt cgtttggtat ggcttcattc     5940

agctccggtt cccaacgatc aaggcgagtt acatgatccc ccatgttgtg caaaaaagcg     6000

gttagctcct tcggtcctcc gatcgttgtc agaagtaagt tggccgcagt gttatcactc     6060

atggttatgg cagcactgca taattctctt actgtcatgc catccgtaag atgcttttct     6120

gtgactggtg agtactcaac caagtcattc tgagaatagt gtatgcggcg accgagttgc     6180

tcttgcccgg cgtcaatacg ggataatacc gcgccacata gcagaacttt aaaagtgctc     6240

atcattggaa aacgttcttc ggggcgaaaa ctctcaagga tcttaccgct gttgagatcc     6300

agttcgatgt aacccactcg tgcacccaac tgatcttcag catcttttac tttcaccagc     6360

gtttctgggt gagcaaaaac aggaaggcaa aatgccgcaa aaaagggaat aagggcgaca     6420

cggaaatgtt gaatactcat actcttcctt tttcaatatt attgaagcat ttatcagggt     6480

tattgtctca tgagcggata catatttgaa tgtatttaga aaaataaaca aataggggtt     6540

ccgcgcacat ttccccgaaa agtgccacct aaattgtaag cgttaatatt ttgttaaaat     6600

tcgcgttaaa tttttgttaa atcagctcat tttttaacca ataggccgaa atcggcaaaa     6660

tcccttataa atcaaaagaa tagaccgaga tagggttgag tgttgttcca gtttggaaca     6720

agagtccact attaaagaac gtggactcca acgtcaaagg gcgaaaaacc gtctatcagg     6780

gcgatggccc actacgtgaa ccatcaccct aatcaagttt tttggggtcg aggtgccgta     6840

aagcactaaa tcggaaccct aaagggagcc cccgatttag agcttgacgg ggaaagccgg     6900

cgaacgtggc gagaaaggaa gggaagaaag cgaaaggagc gggcgctagg gcgctggcaa     6960

gtgtagcggt cacgctgcgc gtaaccacca cacccgccgc gcttaatgcg ccgctacagg     7020

gcgcgtccca ttcgccattc aggctgcgca actgttggga agggcgatcg gtgcgggcct     7080

cttcgctatt acgccagctg gcgaaagggg gatgtgctgc aaggcgatta agttgggtaa     7140

cgccagggtt ttcccagtca cgacgttgta aaacgacggc cagtgagcgc gcgtaatacg     7200

actcactata gggcgaattg ggtaccgggc cccccctcga tcgaggtcga cggtatcggg     7260

ggagctcgca gggtctccat tttgaagcgg gaggtttgaa cgcgcagccg ccatgccggg     7320

gttttacgag attgt                                                      7335


<210>  18
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  Forward primer

<400>  18
tacataactt acggtaaatg gc                                                22


<210>  19
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  Reverse primer

<400>  19
aaagtcccta ttggcgttac t                                                 21


