﻿               SEQUENCE LISTING

<110> METAFORA BIOSYSTEMS
      CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
      UNIVERSITÉ DE MONTPELLIER
      UNIVERSITÉ PARIS DESCARTES - PARIS 5
      IVANOVA SVILENA

<120> USE OF RECEPTOR-BINDING DOMAIN DERIVED FROM BOVINE LEUKEMIA VIRUS FOR THE DIAGNOSIS OR TREATMENT OF CATIONIC L-AMINO ACID TRANSPORTER-RELATED DISEASES

<130> CV - 546/PCT

<160> 49

<170> BiSSAP 1.3.6

<210> 1
<211> 629
<212> PRT
<213> Homo sapiens


<220> 
<223> CAT1 amino acid sequence

<400> 1
Met Gly Cys Lys Val Leu Leu Asn Ile Gly Gln Gln Met Leu Arg Arg 
1               5                   10                  15      
Lys Val Val Asp Cys Ser Arg Glu Glu Thr Arg Leu Ser Arg Cys Leu 
            20                  25                  30          
Asn Thr Phe Asp Leu Val Ala Leu Gly Val Gly Ser Thr Leu Gly Ala 
        35                  40                  45              
Gly Val Tyr Val Leu Ala Gly Ala Val Ala Arg Glu Asn Ala Gly Pro 
    50                  55                  60                  
Ala Ile Val Ile Ser Phe Leu Ile Ala Ala Leu Ala Ser Val Leu Ala 
65                  70                  75                  80  
Gly Leu Cys Tyr Gly Glu Phe Gly Ala Arg Val Pro Lys Thr Gly Ser 
                85                  90                  95      
Ala Tyr Leu Tyr Ser Tyr Val Thr Val Gly Glu Leu Trp Ala Phe Ile 
            100                 105                 110         
Thr Gly Trp Asn Leu Ile Leu Ser Tyr Ile Ile Gly Thr Ser Ser Val 
        115                 120                 125             
Ala Arg Ala Trp Ser Ala Thr Phe Asp Glu Leu Ile Gly Arg Pro Ile 
    130                 135                 140                 
Gly Glu Phe Ser Arg Thr His Met Thr Leu Asn Ala Pro Gly Val Leu 
145                 150                 155                 160 
Ala Glu Asn Pro Asp Ile Phe Ala Val Ile Ile Ile Leu Ile Leu Thr 
                165                 170                 175     
Gly Leu Leu Thr Leu Gly Val Lys Glu Ser Ala Met Val Asn Lys Ile 
            180                 185                 190         
Phe Thr Cys Ile Asn Val Leu Val Leu Gly Phe Ile Met Val Ser Gly 
        195                 200                 205             
Phe Val Lys Gly Ser Val Lys Asn Trp Gln Leu Thr Glu Glu Asp Phe 
    210                 215                 220                 
Gly Asn Thr Ser Gly Arg Leu Cys Leu Asn Asn Asp Thr Lys Glu Gly 
225                 230                 235                 240 
Lys Pro Gly Val Gly Gly Phe Met Pro Phe Gly Phe Ser Gly Val Leu 
                245                 250                 255     
Ser Gly Ala Ala Thr Cys Phe Tyr Ala Phe Val Gly Phe Asp Cys Ile 
            260                 265                 270         
Ala Thr Thr Gly Glu Glu Val Lys Asn Pro Gln Lys Ala Ile Pro Val 
        275                 280                 285             
Gly Ile Val Ala Ser Leu Leu Ile Cys Phe Ile Ala Tyr Phe Gly Val 
    290                 295                 300                 
Ser Ala Ala Leu Thr Leu Met Met Pro Tyr Phe Cys Leu Asp Asn Asn 
305                 310                 315                 320 
Ser Pro Leu Pro Asp Ala Phe Lys His Val Gly Trp Glu Gly Ala Lys 
                325                 330                 335     
Tyr Ala Val Ala Val Gly Ser Leu Cys Ala Leu Ser Ala Ser Leu Leu 
            340                 345                 350         
Gly Ser Met Phe Pro Met Pro Arg Val Ile Tyr Ala Met Ala Glu Asp 
        355                 360                 365             
Gly Leu Leu Phe Lys Phe Leu Ala Asn Val Asn Asp Arg Thr Lys Thr 
    370                 375                 380                 
Pro Ile Ile Ala Thr Leu Ala Ser Gly Ala Val Ala Ala Val Met Ala 
385                 390                 395                 400 
Phe Leu Phe Asp Leu Lys Asp Leu Val Asp Leu Met Ser Ile Gly Thr 
                405                 410                 415     
Leu Leu Ala Tyr Ser Leu Val Ala Ala Cys Val Leu Val Leu Arg Tyr 
            420                 425                 430         
Gln Pro Glu Gln Pro Asn Leu Val Tyr Gln Met Ala Ser Thr Ser Asp 
        435                 440                 445             
Glu Leu Asp Pro Ala Asp Gln Asn Glu Leu Ala Ser Thr Asn Asp Ser 
    450                 455                 460                 
Gln Leu Gly Phe Leu Pro Glu Ala Glu Met Phe Ser Leu Lys Thr Ile 
465                 470                 475                 480 
Leu Ser Pro Lys Asn Met Glu Pro Ser Lys Ile Ser Gly Leu Ile Val 
                485                 490                 495     
Asn Ile Ser Thr Ser Leu Ile Ala Val Leu Ile Ile Thr Phe Cys Ile 
            500                 505                 510         
Val Thr Val Leu Gly Arg Glu Ala Leu Thr Lys Gly Ala Leu Trp Ala 
        515                 520                 525             
Val Phe Leu Leu Ala Gly Ser Ala Leu Leu Cys Ala Val Val Thr Gly 
    530                 535                 540                 
Val Ile Trp Arg Gln Pro Glu Ser Lys Thr Lys Leu Ser Phe Lys Val 
545                 550                 555                 560 
Pro Phe Leu Pro Val Leu Pro Ile Leu Ser Ile Phe Val Asn Val Tyr 
                565                 570                 575     
Leu Met Met Gln Leu Asp Gln Gly Thr Trp Val Arg Phe Ala Val Trp 
            580                 585                 590         
Met Leu Ile Gly Phe Ile Ile Tyr Phe Gly Tyr Gly Leu Trp His Ser 
        595                 600                 605             
Glu Glu Ala Ser Leu Asp Ala Asp Gln Ala Arg Thr Pro Asp Gly Asn 
    610                 615                 620                 
Leu Asp Gln Cys Lys 
625                 

<210> 2
<211> 1890
<212> DNA
<213> Homo sapiens


<220> 
<223> CAT1 nucleic acid sequence

<400> 2
atggggtgca aagtcctgct caacattggg cagcagatgc tgcggcggaa ggtggtggac      60

tgtagccggg aggagacgcg gctgtctcgc tgcctgaaca cttttgatct ggtggccctc     120

ggggtgggca gcacactggg tgctggtgtc tacgtcctgg ctggagctgt ggcccgtgag     180

aatgcaggcc ctgccattgt catctccttc ctgatcgctg cgctggcctc agtgctggct     240

ggcctgtgct atggcgagtt tggtgctcgg gtccccaaga cgggctcagc ttacctctac     300

agctatgtca ccgttggaga gctctgggcc ttcatcaccg gctggaactt aatcctctcc     360

tacatcatcg gtacttcaag cgtagcgagg gcctggagcg ccaccttcga cgagctgata     420

ggcagaccca tcggggagtt ctcacggaca cacatgactc tgaacgcccc cggcgtgctg     480

gctgaaaacc ccgacatatt cgcagtgatc ataattctca tcttgacagg acttttaact     540

cttggtgtga aagagtcggc catggtcaac aaaatattca cttgtattaa cgtcctggtc     600

ctgggcttca taatggtgtc aggatttgtg aaaggatcgg ttaaaaactg gcagctcacg     660

gaggaggatt ttgggaacac atcaggccgt ctctgtttga acaatgacac aaaagaaggg     720

aagcccggtg ttggtggatt catgcccttc gggttctctg gtgtcctgtc gggggcagcg     780

acttgcttct atgccttcgt gggctttgac tgcatcgcca ccacaggtga agaggtgaag     840

aacccacaga aggccatccc cgtggggatc gtggcgtccc tcttgatctg cttcatcgcc     900

tactttgggg tgtcggctgc cctcacgctc atgatgccct acttctgcct ggacaataac     960

agccccctgc ccgacgcctt taagcacgtg ggctgggaag gtgccaagta cgcagtggcc    1020

gtgggctccc tctgcgctct ttccgccagt cttctaggtt ccatgtttcc catgcctcgg    1080

gttatctatg ccatggctga ggatggactg ctatttaaat tcttagccaa cgtcaatgat    1140

aggaccaaaa caccaataat cgccacatta gcctcgggtg ccgttgctgc tgtgatggcc    1200

ttcctctttg acctgaagga cttggtggac ctcatgtcca ttggcactct cctggcttac    1260

tcgttggtgg ctgcctgtgt gttggtctta cggtaccagc cagagcagcc taacctggta    1320

taccagatgg ccagtacttc cgacgagtta gatccagcag accaaaatga attggcaagc    1380

accaatgatt cccagctggg gtttttacca gaggcagaga tgttctcttt gaaaaccata    1440

ctctcaccca aaaacatgga gccttccaaa atctctgggc taattgtgaa catttcaacc    1500

agccttatag ctgttctcat catcaccttc tgcattgtga ccgtgcttgg aagggaggct    1560

ctcaccaaag gggcgctgtg ggcagtcttt ctgctcgcag ggtctgccct cctctgtgcc    1620

gtggtcacgg gcgtcatctg gaggcagccc gagagcaaga ccaagctctc atttaaggtt    1680

cccttcctgc cagtgctccc catcctgagc atcttcgtga acgtctatct catgatgcag    1740

ctggaccagg gcacctgggt ccggtttgct gtgtggatgc tgataggctt catcatctac    1800

tttggctatg gcctgtggca cagcgaggag gcgtccctgg atgccgacca agcaaggact    1860

cctgacggca acttggacca gtgcaagtga                                     1890


<210> 3
<211> 215
<212> PRT
<213> Artificial Sequence


<220> 
<223> BLV.RBD

<400> 3
Met Pro Lys Glu Arg Arg Ser Arg Arg Arg Pro Gln Pro Ile Ile Arg 
1               5                   10                  15      
Trp Val Ser Leu Thr Leu Thr Leu Leu Ala Leu Cys Gln Pro Ile Gln 
            20                  25                  30          
Thr Trp Arg Cys Ser Leu Ser Leu Gly Asn Gln Gln Trp Met Thr Thr 
        35                  40                  45              
Tyr Asn Gln Glu Ala Lys Phe Phe Ile Ser Ile Asp Gln Ile Leu Glu 
    50                  55                  60                  
Ala His Asn Gln Ser Pro Phe Cys Pro Arg Ser Pro Arg Tyr Thr Leu 
65                  70                  75                  80  
Asp Phe Val Asn Gly Tyr Pro Lys Ile Tyr Trp Pro Pro Pro Gln Gly 
                85                  90                  95      
Arg Arg Arg Phe Gly Ala Arg Ala Met Val Thr Tyr Asp Cys Glu Pro 
            100                 105                 110         
Arg Cys Pro Tyr Val Gly Ala Asp His Phe Asp Cys Pro His Trp Asp 
        115                 120                 125             
Asn Ala Ser Gln Ala Asp Gln Gly Ser Phe Tyr Val Asn His Gln Thr 
    130                 135                 140                 
Leu Phe Leu His Leu Lys Gln Cys His Gly Ile Phe Thr Leu Thr Trp 
145                 150                 155                 160 
Glu Ile Trp Gly Tyr Asp Pro Leu Ile Thr Phe Ser Leu His Lys Ile 
                165                 170                 175     
Pro Asp Pro Pro Gln Pro Asp Phe Pro Gln Leu Asn Ser Asp Trp Val 
            180                 185                 190         
Pro Ser Val Arg Ser Trp Ala Leu Leu Leu Asn Gln Thr Ala Arg Ala 
        195                 200                 205             
Phe Pro Asp Cys Ala Ile Cys 
    210                 215 

<210> 4
<211> 181
<212> PRT
<213> Artificial Sequence


<220> 
<223> BLV.RBD

<400> 4
Met Pro Lys Glu Arg Arg Ser Arg Arg Arg Pro Gln Pro Ile Ile Arg 
1               5                   10                  15      
Trp Val Ser Leu Thr Leu Thr Leu Leu Ala Leu Cys Gln Pro Ile Gln 
            20                  25                  30          
Thr Trp Arg Cys Ser Leu Ser Leu Gly Asn Gln Gln Trp Met Thr Thr 
        35                  40                  45              
Tyr Asn Gln Glu Ala Lys Phe Phe Ile Ser Ile Asp Gln Ile Leu Glu 
    50                  55                  60                  
Ala His Asn Gln Ser Pro Phe Cys Pro Arg Ser Pro Arg Tyr Thr Leu 
65                  70                  75                  80  
Asp Phe Val Asn Gly Tyr Pro Lys Ile Tyr Trp Pro Pro Pro Gln Gly 
                85                  90                  95      
Arg Arg Arg Phe Gly Ala Arg Ala Met Val Thr Tyr Asp Cys Glu Pro 
            100                 105                 110         
Arg Cys Pro Tyr Val Gly Ala Asp His Phe Asp Cys Pro His Trp Asp 
        115                 120                 125             
Asn Ala Ser Gln Ala Asp Gln Gly Ser Phe Tyr Val Asn His Gln Thr 
    130                 135                 140                 
Leu Phe Leu His Leu Lys Gln Cys His Gly Ile Phe Thr Leu Thr Trp 
145                 150                 155                 160 
Glu Ile Trp Gly Tyr Asp Pro Leu Ile Thr Phe Ser Leu His Lys Ile 
                165                 170                 175     
Pro Asp Pro Pro Gln 
            180     

<210> 5
<211> 549
<212> DNA
<213> Artificial Sequence


<220> 
<223> BLV.RBD

<400> 5
accaccatgc ccaaagaacg acggtcccga agacgcccac aaccgatcat cagatggatc      60

tccctcactc ttactctcct cgctctctgt cagcccatcc agacttggag atgctccctg     120

tccctaggaa atcaacaatg gatgacaaca tataaccaag aggcaaaatt tttcatctcc     180

attgaccaaa tactagaggc tcataatcaa tcacctttct gtcccaggtc tcccagatac     240

accttggact ttgtaaatgg ttatcctaag atctattggc cccccccaca agggcggcgc     300

cggtttggag ccagggccat ggtcacatat gattgcgagc cccgatgccc ttatgtgggg     360

gcagatcact tcgactgccc ccactgggac aatgcctccc aggccgatca aggatccttt     420

tatgtcaatc atcagacttt attcctgcat ctcaaacaat gtcatggaat tttcactcta     480

acctgggaaa tatggggata tgatcccctg atcacttttt ctttacataa aatccctgct     540

ccgccacaa                                                             549


<210> 6
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> siRNA CAT1

<400> 6
uaauugcacc uuuggcugct t                                              21


<210> 7
<211> 4329
<212> DNA
<213> Artificial Sequence


<220> 
<223> H2.RBD tagged with rFc

<400> 7
gaattcgagc ttgcatgcct gcaggtcgtt acataactta cggtaaatgg cccgcctggc       60

tgaccgccca acgacccccg cccattgacg tcaataatga cgtatgttcc catagtaacg      120

ccaataggga ctttccattg acgtcaatgg gtggagtatt tacggtaaac tgcccacttg      180

gcagtacatc aagtgtatca tatgccaagt acgcccccta ttgacgtcaa tgacggtaaa      240

tggcccgcct ggcattatgc ccagtacatg accttatggg actttcctac ttggcagtac      300

atctacgtat tagtcatcgc tattaccatg gtgatgcggt tttggcagta catcaatggg      360

cgtggatagc ggtttgactc acggggattt ccaagtctcc accccattga cgtcaatggg      420

agtttgtttt ggcaccaaaa tcaacgggac tttccaaaat gtcgtaacaa ctccgcccca      480

ttgacgcaaa tgggcggtag gcgtgtacgg tgggaggtct atataagcag agctcgttta      540

gtgaaccgtc agatcgcctg gagacgccat ccacgctgtt ttgacctcca tagaagacac      600

cgggaccgat ccagcctccg gactctagag gatccggtac tcgaggaact gaaaaaccag      660

aaagttaact ggtaagttta gtctttttgt cttttatttc aggtcccgga tccggtggtg      720

gtgcaaatca aagaactgct cctcagtgga tgttgccttt acttctaggc ctgtacggaa      780

gtgttacttc tgctctaaaa gctgcggaat tgtacccgcg gccgcaccac catgggtaat      840

gttttcttcc tacttttatt cagtctcaca cattttccac tagcccagca gagccgatgc      900

acactcacga ttggtatctc ctcctaccac tccagcccct gtagcccaac ccaacccgtc      960

tgcacgtgga acctcgacct taattcccta acaacggacc aacgactaca ccccccctgc     1020

cctaacctaa ttacttactc tggcttccat aagacttatt ccttatactt attcccacat     1080

tggataaaaa agccaaacag acagggccta gggtactact cgccttccta caatgaccct     1140

tgctcgctac aatgccccta cttgggctgc caagcatgga catccgcata cacgggcccc     1200

gtctccagtc catcctggaa gtttcattca gatgtaaatt tcacccagga agtcagccaa     1260

gtgtcccttc gactacactt ctctaagtgc ggctcctcca tgaccctcct agtagatgcc     1320

cctggatatg atcctttatg gttcatcacc tcagaaccca ctcagggatc tattgaggga     1380

cgctacccat atgacgtccc ggactacgct tacccgtatg atgttccaga ttatgctcat     1440

caccatcacc atcattgagg ccgcggggat ccagacatga taagatacat tgatgagttt     1500

ggacaaacca caactagaat gcagtgaaaa aaatgcttta tttgtgaaat ttgtgatgct     1560

attgctttat ttgtaaccat tataagctgc aataaacaag ttaacaacaa caattgcatt     1620

cattttatgt ttcaggttca gggggaggtg tgggaggttt tttcggatcc tctagagtcg     1680

acctgcaggc atgcaagctt ggcgtaatca tggtcatagc tgtttcctgt gtgaaattgt     1740

tatccgctca caattccaca caacatacga gccggaagca taaagtgtaa agcctggggt     1800

gcctaatgag tgagctaact cacattaatt gcgttgcgct cactgcccgc tttccagtcg     1860

ggaaacctgt cgtgccagct gcattaatga atcggccaac gcgcggggag aggcggtttg     1920

cgtattgggc gctcttccgc ttcctcgctc actgactcgc tgcgctcggt cgttcggctg     1980

cggcgagcgg tatcagctca ctcaaaggcg gtaatacggt tatccacaga atcaggggat     2040

aacgcaggaa agaacatgtg agcaaaaggc cagcaaaagg ccaggaaccg taaaaaggcc     2100

gcgttgctgg cgtttttcca taggctccgc ccccctgacg agcatcacaa aaatcgacgc     2160

tcaagtcaga ggtggcgaaa cccgacagga ctataaagat accaggcgtt tccccctgga     2220

agctccctcg tgcgctctcc tgttccgacc ctgccgctta ccggatacct gtccgccttt     2280

ctcccttcgg gaagcgtggc gctttctcat agctcacgct gtaggtatct cagttcggtg     2340

taggtcgttc gctccaagct gggctgtgtg cacgaacccc ccgttcagcc cgaccgctgc     2400

gccttatccg gtaactatcg tcttgagtcc aacccggtaa gacacgactt atcgccactg     2460

gcagcagcca ctggtaacag gattagcaga gcgaggtatg taggcggtgc tacagagttc     2520

ttgaagtggt ggcctaacta cggctacact agaaggacag tatttggtat ctgcgctctg     2580

ctgaagccag ttaccttcgg aaaaagagtt ggtagctctt gatccggcaa acaaaccacc     2640

gctggtagcg gtggtttttt tgtttgcaag cagcagatta cgcgcagaaa aaaaggatct     2700

caagaagatc ctttgatctt ttctacgggg tctgacgctc agtggaacga aaactcacgt     2760

taagggattt tggtcatgag attatcaaaa aggatcttca cctagatcct tttaaattaa     2820

aaatgaagtt ttaaatcaat ctaaagtata tatgagtaaa cttggtctga cagttaccaa     2880

tgcttaatca gtgaggcacc tatctcagcg atctgtctat ttcgttcatc catagttgcc     2940

tgactccccg tcgtgtagat aactacgata cgggagggct taccatctgg ccccagtgct     3000

gcaatgatac cgcgagaccc acgctcaccg gctccagatt tatcagcaat aaaccagcca     3060

gccggaaggg ccgagcgcag aagtggtcct gcaactttat ccgcctccat ccagtctatt     3120

aattgttgcc gggaagctag agtaagtagt tcgccagtta atagtttgcg caacgttgtt     3180

gccattgcta caggcatcgt ggtgtcacgc tcgtcgtttg gtatggcttc attcagctcc     3240

ggttcccaac gatcaaggcg agttacatga tcccccatgt tgtgcaaaaa agcggttagc     3300

tccttcggtc ctccgatcgt tgtcagaagt aagttggccg cagtgttatc actcatggtt     3360

atggcagcac tgcataattc tcttactgtc atgccatccg taagatgctt ttctgtgact     3420

ggtgagtact caaccaagtc attctgagaa tagtgtatgc ggcgaccgag ttgctcttgc     3480

ccggcgtcaa tacgggataa taccgcgcca catagcagaa ctttaaaagt gctcatcatt     3540

ggaaaacgtt cttcggggcg aaaactctca aggatcttac cgctgttgag atccagttcg     3600

atgtaaccca ctcgtgcacc caactgatct tcagcatctt ttactttcac cagcgtttct     3660

gggtgagcaa aaacaggaag gcaaaatgcc gcaaaaaagg gaataagggc gacacggaaa     3720

tgttgaatac tcatactctt cctttttcaa tattattgaa gcatttatca gggttattgt     3780

ctcatgagcg gatacatatt tgaatgtatt tagaaaaata aacaaatagg ggttccgcgc     3840

acatttcccc gaaaagtgcc acctgacgtc taagaaacca ttattatcat gacattaacc     3900

tataaaaata ggcgtatcac gaggcccttt cgtctcgcgc gtttcggtga tgacggtgaa     3960

aacctctgac acatgcagct cccggagacg gtcacagctt gtctgtaagc ggatgccggg     4020

agcagacaag cccgtcaggg cgcgtcagcg ggtgttggcg ggtgtcgggg ctggcttaac     4080

tatgcggcat cagagcagat tgtactgaga gtgcaccata tgcggtgtga aataccgcac     4140

agatgcgtaa ggagaaaata ccgcatcagg cgccattcgc cattcaggct gcgcaactgt     4200

tgggaagggc gatcggtgcg ggcctcttcg ctattacgcc agctggcgaa agggggatgt     4260

gctgcaaggc gattaagttg ggtaacgcca gggttttccc agtcacgacg ttgtaaaacg     4320

acggccagt                                                             4329


<210> 8
<211> 228
<212> PRT
<213> Artificial Sequence


<220> 
<223> Rabbit Fc fragment

<400> 8
Ala Pro Ser Thr Cys Ser Lys Pro Thr Cys Pro Pro Pro Glu Leu Leu 
1               5                   10                  15      
Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            20                  25                  30          
Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        35                  40                  45              
Gln Asp Asp Pro Glu Val Gln Phe Thr Trp Tyr Ile Asn Asn Glu Gln 
    50                  55                  60                  
Val Arg Thr Ala Arg Pro Pro Leu Arg Glu Gln Gln Phe Asp Cys Thr 
65                  70                  75                  80  
Ile Arg Val Val Ser Thr Leu Pro Ile Ala His Gln Asp Trp Leu Arg 
                85                  90                  95      
Gly Lys Glu Phe Lys Cys Lys Val His Asn Lys Ala Leu Pro Ala Pro 
            100                 105                 110         
Ile Glu Lys Thr Ile Ser Lys Ala Arg Gly Gln Pro Leu Glu Pro Lys 
        115                 120                 125             
Val Tyr Thr Met Gly Pro Pro Arg Glu Glu Leu Ser Ser Arg Ser Val 
    130                 135                 140                 
Ser Leu Thr Cys Met Ile Asn Gly Phe Tyr Pro Ser Asp Ile Ser Val 
145                 150                 155                 160 
Glu Trp Glu Lys Asn Gly Lys Ala Glu Asp Asn Tyr Lys Thr Thr Pro 
                165                 170                 175     
Ala Val Leu Asp Ser Asp Gly Ser Tyr Phe Leu Tyr Ser Lys Leu Ser 
            180                 185                 190         
Val Pro Thr Ser Glu Trp Gln Arg Gly Asp Val Phe Thr Cys Ser Val 
        195                 200                 205             
Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Ile Ser Arg 
    210                 215                 220                 
Ser Pro Gly Lys 
225             

<210> 9
<211> 687
<212> DNA
<213> Artificial Sequence


<220> 
<223> Rabbit Fc fragment

<400> 9
gcaccctcga catgcagcaa gcccacgtgc ccaccccctg aactcctggg gggaccgtct      60

gtcttcatct tccccccaaa acccaaggac accctcatga tctcacgcac ccccgaggtc     120

acatgcgtgg tggtggacgt gagccaggat gaccccgagg tgcagttcac atggtacata     180

aacaacgagc aggtgcgcac cgcccggccg ccgctacggg agcagcagtt caacagcacg     240

atccgcgtgg tcagcaccct ccccatcacg caccaggact ggctgagggg caaggagttc     300

aagtgcaaag tccacaacaa ggcactcccg gcccccatcg agaaaaccat ctccaaagcc     360

agagggcagc ccctggagcc gaaggtctac accatgggcc ctccccggga ggagctgagc     420

agcaggtcgg tcagcctgac ctgcatgatc aacggcttct acccttccga catctcggtg     480

gagtgggaga agaacgggaa ggcagaggac aactacaaga ccacgccggc cgtgctggac     540

agcgacggct cctacttcct ctacaacaag ctctcagtgc ccacgagtga gtggcagcgg     600

ggcgacgtct tcacctgctc cgtgatgcac gaggccttgc acaaccacta cacgcagaag     660

tccatctccc gctctccggg taaatga                                         687


<210> 10
<211> 229
<212> PRT
<213> Artificial Sequence


<220> 
<223> Mouse Fc fragment

<400> 10
Val Asp Val Pro Arg Asp Cys Gly Cys Lys Pro Cys Ile Cys Thr Val 
1               5                   10                  15      
Pro Glu Val Ser Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Val 
            20                  25                  30          
Leu Thr Ile Thr Leu Thr Pro Lys Val Thr Cys Val Val Val Asp Ile 
        35                  40                  45              
Ser Lys Asp Asp Pro Glu Val Gln Phe Ser Trp Phe Val Asp Asp Val 
    50                  55                  60                  
Glu Val His Thr Ala Gln Thr Gln Pro Arg Glu Glu Gln Phe Asn Ser 
65                  70                  75                  80  
Thr Phe Arg Ser Val Ser Glu Leu Pro Ile Met His Gln Asp Trp Leu 
                85                  90                  95      
Asn Gly Lys Glu Phe Lys Cys Arg Val Asn Ser Ala Ala Phe Pro Ala 
            100                 105                 110         
Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Arg Pro Lys Ala Pro 
        115                 120                 125             
Gln Val Tyr Thr Ile Pro Pro Pro Lys Glu Gln Met Ala Lys Asp Lys 
    130                 135                 140                 
Val Ser Leu Thr Cys Met Ile Thr Asp Phe Phe Pro Glu Asp Ile Thr 
145                 150                 155                 160 
Val Glu Trp Gln Trp Asn Gly Gln Pro Ala Glu Asn Tyr Lys Asn Thr 
                165                 170                 175     
Gln Pro Ile Met Asp Thr Asp Gly Ser Tyr Phe Val Tyr Ser Lys Leu 
            180                 185                 190         
Asn Val Gln Lys Ser Asn Trp Glu Ala Gly Asn Thr Phe Thr Cys Ser 
        195                 200                 205             
Val Leu His Glu Gly Leu His Asn His His Thr Glu Lys Ser Leu Ser 
    210                 215                 220                 
His Ser Pro Gly Lys 
225                 

<210> 11
<211> 690
<212> DNA
<213> Artificial Sequence


<220> 
<223> Mouse Fc fragment

<400> 11
gtcgacgtgc ccagggattg tggttgtaag ccttgcatat gtacagtccc agaagtatca      60

tctgtcttca tcttcccccc aaagcccaag gatgtgctca ccattactct gactcctaag     120

gtcacgtgtg ttgtggtaga catcagcaag gatgatcccg aggtccagtt cagctggttt     180

gtagatgatg tggaggtgca cacagctcag acgcaacccc gggaggagca gttcaacagc     240

actttccgct cagtcagtga acttcccatc atgcaccagg actggctcaa tggcaaggag     300

ttcaaatgca gggtcaacag tgcagctttc cctgccccca tcgagaaaac catctccaaa     360

accaaaggca gaccgaaggc tccacaggtg tacaccattc cacctcccaa ggagcagatg     420

gccaaggata aagtcagtct gacctgcatg ataacagact tcttccctga agacattact     480

gtggagtggc agtggaatgg gcagccagcg gagaactaca agaacactca gcccatcatg     540

gacacagatg gctcttactt cgtctacagc aagctcaatg tgcagaagag caactgggag     600

gcaggaaata ctttcacctg ctctgtgtta catgagggcc tgcacaacca ccatactgag     660

aagagcctct cccactctcc tggtaaatga                                      690


<210> 12
<211> 1242
<212> DNA
<213> Artificial Sequence


<220> 
<223> BLV.RBD tagged with a rabbit Fc

<400> 12
accaccatgc ccaaagaacg acggtcccga agacgcccac aaccgatcat cagatggatc      60

tccctcactc ttactctcct cgctctctgt cagcccatcc agacttggag atgctccctg     120

tccctaggaa atcaacaatg gatgacaaca tataaccaag aggcaaaatt tttcatctcc     180

attgaccaaa tactagaggc tcataatcaa tcacctttct gtcccaggtc tcccagatac     240

accttggact ttgtaaatgg ttatcctaag atctattggc cccccccaca agggcggcgc     300

cggtttggag ccagggccat ggtcacatat gattgcgagc cccgatgccc ttatgtgggg     360

gcagatcact tcgactgccc ccactgggac aatgcctccc aggccgatca aggatccttt     420

tatgtcaatc atcagacttt attcctgcat ctcaaacaat gtcatggaat tttcactcta     480

acctgggaaa tatggggata tgatcccctg atcacttttt ctttacataa aatccctgct     540

ccgccacaag gatccgcacc ctcgacatgc agcaagccca cgtgcccacc ccctgaactc     600

ctggggggac cgtctgtctt catcttcccc ccaaaaccca aggacaccct catgatctca     660

cgcacccccg aggtcacatg cgtggtggtg gacgtgagcc aggatgaccc cgaggtgcag     720

ttcacatggt acataaacaa cgagcaggtg cgcaccgccc ggccgccgct acgggagcag     780

cagttcgact gcacgatccg cgtggtcagc accctcccca tcgcgcacca ggactggctg     840

aggggcaagg agttcaagtg caaagtccac aacaaggcac tcccggcccc catcgagaaa     900

accatctcca aagccagagg gcagcccctg gagccgaagg tctacaccat gggccctccc     960

cgggaggagc tgagcagcag gtcggtcagc ctgacctgca tgatcaacgg cttctaccct    1020

tccgacatct cggtggagtg ggagaagaac gggaaggcag aggacaacta caagaccacg    1080

ccggccgtgc tggacagcga cggctcctac ttcctctaca gcaagctctc agtgcccacg    1140

agtgagtggc agcggggcga cgtcttcacc tgctccgtga tgcacgaggc cttgcacaac    1200

cactacacgc agaagtccat ctcccgctct ccgggtaaat ga                       1242


<210> 13
<211> 515
<212> PRT
<213> Artificial Sequence


<220> 
<223> Amino acid sequence of BLV envelope

<400> 13
Met Pro Lys Glu Arg Arg Ser Arg Arg Arg Pro Gln Pro Ile Ile Arg 
1               5                   10                  15      
Trp Val Ser Leu Thr Leu Thr Leu Leu Ala Leu Cys Gln Pro Ile Gln 
            20                  25                  30          
Thr Trp Arg Cys Ser Leu Ser Leu Gly Asn Gln Gln Trp Met Thr Thr 
        35                  40                  45              
Tyr Asn Gln Glu Ala Lys Phe Phe Ile Ser Ile Asp Gln Ile Leu Glu 
    50                  55                  60                  
Ala His Asn Gln Ser Pro Phe Cys Pro Arg Ser Pro Arg Tyr Thr Leu 
65                  70                  75                  80  
Asp Phe Val Asn Gly Tyr Pro Lys Ile Tyr Trp Pro Pro Pro Gln Gly 
                85                  90                  95      
Arg Arg Arg Phe Gly Ala Arg Ala Met Val Thr Tyr Asp Cys Glu Pro 
            100                 105                 110         
Arg Cys Pro Tyr Val Gly Ala Asp His Phe Asp Cys Pro His Trp Asp 
        115                 120                 125             
Asn Ala Ser Gln Ala Asp Gln Gly Ser Phe Tyr Val Asn His Gln Thr 
    130                 135                 140                 
Leu Phe Leu His Leu Lys Gln Cys His Gly Ile Phe Thr Leu Thr Trp 
145                 150                 155                 160 
Glu Ile Trp Gly Tyr Asp Pro Leu Ile Thr Phe Ser Leu His Lys Ile 
                165                 170                 175     
Pro Asp Pro Pro Gln Pro Asp Phe Pro Gln Leu Asn Ser Asp Trp Val 
            180                 185                 190         
Pro Ser Val Arg Ser Trp Ala Leu Leu Leu Asn Gln Thr Ala Arg Ala 
        195                 200                 205             
Phe Pro Asp Cys Ala Ile Cys Trp Glu Pro Ser Pro Pro Trp Ala Pro 
    210                 215                 220                 
Glu Ile Leu Val Tyr Asn Lys Thr Ile Ser Ser Ser Gly Pro Gly Leu 
225                 230                 235                 240 
Ala Leu Pro Asp Ala Gln Ile Phe Trp Val Asn Thr Ser Leu Phe Asn 
                245                 250                 255     
Thr Thr Gln Gly Trp His His Pro Ser Gln Arg Leu Leu Phe Asn Val 
            260                 265                 270         
Ser Gln Gly Asn Ala Leu Leu Leu Pro Pro Ile Ser Leu Val Asn Leu 
        275                 280                 285             
Ser Thr Ala Ser Ser Ala Pro Pro Thr Arg Val Arg Arg Ser Pro Val 
    290                 295                 300                 
Ala Ala Leu Thr Leu Gly Leu Ala Leu Ser Val Gly Leu Thr Gly Ile 
305                 310                 315                 320 
Asn Val Ala Val Ser Ala Leu Ser His Gln Arg Leu Thr Ser Leu Ile 
                325                 330                 335     
His Val Leu Glu Gln Asp Gln Gln Arg Leu Ile Thr Ala Ile Asn Gln 
            340                 345                 350         
Thr His Tyr Asn Leu Leu Asn Val Ala Ser Val Val Ala Gln Asn Arg 
        355                 360                 365             
Arg Gly Leu Asp Trp Leu Tyr Ile Arg Leu Gly Phe Gln Ser Leu Cys 
    370                 375                 380                 
Pro Thr Ile Asn Glu Pro Cys Cys Phe Leu Arg Ile Gln Asn Asp Ser 
385                 390                 395                 400 
Ile Ile Arg Leu Gly Asp Leu Gln Pro Leu Ser Gln Arg Val Ser Thr 
                405                 410                 415     
Asp Trp Gln Trp Pro Trp Asn Trp Asp Leu Gly Leu Thr Ala Trp Val 
            420                 425                 430         
Arg Glu Thr Ile His Ser Val Leu Ser Leu Phe Leu Leu Ala Leu Phe 
        435                 440                 445             
Leu Leu Phe Leu Ala Pro Cys Leu Ile Lys Cys Leu Thr Ser Arg Leu 
    450                 455                 460                 
Leu Lys Leu Leu Arg Gln Ala Pro His Phe Pro Glu Ile Ser Phe Pro 
465                 470                 475                 480 
Pro Lys Pro Asp Ser Asp Tyr Gln Ala Leu Leu Pro Ser Ala Pro Glu 
                485                 490                 495     
Ile Tyr Ser His Leu Ser Pro Thr Lys Pro Asp Tyr Ile Asn Leu Arg 
            500                 505                 510         
Pro Cys Pro 
        515 

<210> 14
<211> 1545
<212> DNA
<213> Artificial Sequence


<220> 
<223> Nucleic acid sequence of BLV envelope

<400> 14
atgcccaaag aacgacggtc ccgaagacgc ccacaaccga tcatcagatg ggtaagtctc      60

actcttactc tcctcgctct ctgtcagccc atccagactt ggagatgctc cctgtcccta     120

ggaaatcaac aatggatgac aacatataac caagaggcaa aatttttcat ctccattgac     180

caaatactag aggctcataa tcaatcacct ttctgtccca ggtctcccag atacaccttg     240

gactttgtaa atggttatcc taagatctat tggccccccc cacaagggcg gcgccggttt     300

ggagccaggg ccatggtcac atatgattgc gagccccgat gcccttatgt gggggcagat     360

cacttcgact gcccccactg ggacaatgcc tcccaggccg atcaagggtc cttttatgtc     420

aatcatcaga ctttattcct gcatctcaaa caatgtcatg gaattttcac tctaacctgg     480

gaaatatggg gatatgatcc cctgatcacc ttttctttac ataaaatccc tgatccccct     540

caacccgact tccctcagct gaacagtgac tgggttccct ctgtcagatc atgggccctg     600

cttttaaatc aaacggcacg ggccttccca gactgtgcta tatgttggga accctcccct     660

ccctgggctc ccgaaatatt agtatataac aaaaccatct ccagctctgg acccggtctc     720

gccctcccgg acgcccaaat cttctgggtc aacacgtcct tgtttaacac cacccaagga     780

tggcaccacc cttcccagag gttgttgttc aacgtttctc aaggcaacgc cttattattg     840

ccccctatct ccctggttaa tctctctacg gcttcctccg cccctcctac ccgggtcaga     900

cgcagtcccg tcgcagccct gaccttaggc ctagccctgt cagtggggct cactggaatt     960

aatgtagccg tgtctgccct tagccatcag agactcacct ccctgatcca cgttctggag    1020

caagatcagc aacgcttgat cacagcaatt aaccagaccc actataattt gcttaatgtg    1080

gcctctgtgg tcgcccagaa ccgacggggg cttgattggt tgtacatccg gctgggtttt    1140

caaagtctat gtcccacaat caatgaacct tgctgtttcc tgcgcatcca aaatgactcc    1200

attatccgcc tcggtgatct ccagcctctc tcgcaaagag tctctacaga ctggcagtgg    1260

ccctggaatt gggatctggg gctcaccgcc tgggtgcggg aaaccattca ttctgttcta    1320

agcctattcc tattagccct ttttttgctc ttcttggccc cctgcctgat aaaatgcctg    1380

acctctcgcc ttttaaaact cctccggcag gctccccact tccctgaaat ctccttcccc    1440

cctaaacccg attctgatta tcaggccttg ctaccgtctg cgccagagat ctactctcac    1500

ctctccccca ccaaacccga ttacatcaac cttcgaccct gccct                    1545


<210> 15
<211> 515
<212> PRT
<213> Artificial Sequence


<220> 
<223> Amino acid sequence of BLV envelope

<400> 15
Met Pro Lys Lys Arg Arg Ser Arg Arg Arg Pro Gln Pro Ile Ile Arg 
1               5                   10                  15      
Trp Val Ser Leu Thr Leu Thr Leu Leu Ala Leu Cys Arg Pro Ile Gln 
            20                  25                  30          
Thr Trp Arg Cys Ser Leu Ser Leu Gly Asn Gln Gln Trp Met Thr Ala 
        35                  40                  45              
Tyr Asn Gln Glu Ala Lys Phe Ser Ile Ser Ile Asp Gln Ile Leu Glu 
    50                  55                  60                  
Ala His Asn Gln Ser Pro Phe Cys Ala Lys Ser Pro Arg Tyr Thr Leu 
65                  70                  75                  80  
Asp Ser Val Asn Gly Tyr Pro Lys Ile Tyr Trp Pro Pro Pro Gln Gly 
                85                  90                  95      
Arg Arg Arg Phe Gly Ala Arg Ala Met Val Thr Tyr Asp Cys Glu Pro 
            100                 105                 110         
Arg Cys Pro Tyr Val Gly Ala Asp Arg Phe Asp Cys Pro His Trp Asp 
        115                 120                 125             
Asn Ala Ser Gln Ala Asp Gln Gly Ser Phe Tyr Val Asn His Gln Ile 
    130                 135                 140                 
Leu Phe Leu His Leu Lys Gln Cys His Gly Ile Phe Thr Leu Thr Trp 
145                 150                 155                 160 
Glu Ile Trp Gly Tyr Asp Pro Leu Ile Thr Phe Ser Leu His Lys Ile 
                165                 170                 175     
Pro Asp Pro Pro Gln Pro Asp Phe Pro Gln Leu Asn Ser Asp Trp Val 
            180                 185                 190         
Pro Ser Val Arg Ser Trp Ala Leu Leu Leu Asn Gln Thr Ala Arg Ala 
        195                 200                 205             
Phe Pro Asp Cys Ala Ile Cys Trp Glu Pro Ser Pro Pro Trp Ala Pro 
    210                 215                 220                 
Glu Ile Leu Val Tyr Asn Lys Thr Ile Ser Ser Ser Gly Pro Gly Leu 
225                 230                 235                 240 
Ala Leu Pro Asp Ala Gln Ile Phe Trp Val Asn Thr Ser Ser Phe Asn 
                245                 250                 255     
Thr Thr Gln Gly Trp His His Pro Ser Gln Arg Leu Leu Phe Asn Val 
            260                 265                 270         
Ser Gln Gly Asn Ala Leu Leu Leu Pro Pro Ile Ser Leu Val Asn Leu 
        275                 280                 285             
Ser Thr Ala Ser Ser Ala Pro Pro Thr Arg Val Arg Arg Ser Pro Val 
    290                 295                 300                 
Ala Ala Leu Thr Leu Gly Leu Ala Leu Ser Val Gly Leu Thr Gly Ile 
305                 310                 315                 320 
Asn Val Ala Val Ser Ala Leu Ser His Gln Arg Leu Thr Ser Leu Ile 
                325                 330                 335     
His Val Leu Glu Gln Asp Gln Gln Arg Leu Ile Thr Ala Ile Asn Gln 
            340                 345                 350         
Thr His Tyr Asn Leu Leu Asn Val Ala Ser Val Val Ala Gln Asn Arg 
        355                 360                 365             
Arg Gly Leu Asp Trp Leu Tyr Ile Arg Leu Gly Phe Gln Ser Leu Cys 
    370                 375                 380                 
Pro Thr Ile Asn Glu Pro Cys Cys Phe Leu Arg Ile Gln Asn Asp Ser 
385                 390                 395                 400 
Ile Ile Arg Leu Gly Asp Leu Gln Pro Leu Ser Gln Arg Val Ser Thr 
                405                 410                 415     
Asp Trp Gln Trp Pro Trp Asn Trp Asp Leu Gly Leu Thr Ala Trp Val 
            420                 425                 430         
Arg Glu Thr Ile His Ser Val Leu Ser Leu Phe Leu Leu Ala Leu Phe 
        435                 440                 445             
Leu Leu Phe Leu Ala Pro Cys Leu Ile Lys Cys Leu Thr Ser Arg Leu 
    450                 455                 460                 
Leu Lys Leu Leu Arg Gln Ala Pro His Phe Pro Glu Ile Ser Leu Thr 
465                 470                 475                 480 
Pro Lys Pro Asp Ser Asp Tyr Gln Ala Leu Leu Pro Ser Ala Pro Glu 
                485                 490                 495     
Ile Tyr Ser His Leu Ser Pro Val Lys Pro Asp Tyr Ile Asn Leu Arg 
            500                 505                 510         
Pro Cys Pro 
        515 

<210> 16
<211> 1545
<212> DNA
<213> Artificial Sequence


<220> 
<223> Nucleic acid sequence of BLV envelope

<400> 16
atgcctaaaa aacgacggtc ccgaagacgc ccacaaccga tcatcagatg ggtaagtctc      60

actctcactc tcctcgctct ctgtcggccc atccagactt ggagatgctc cctgtcccta     120

ggaaaccaac aatggatgac agcatataac caagaggcaa aattttccat ctccattgac     180

caaatactag aggctcataa tcagtcacct ttctgtgcca agtctcccag atacaccttg     240

gactctgtaa atggctatcc taagatctac tggccccccc cacaagggcg gcgccggttt     300

ggagccaggg ccatggtcac atatgattgc gagccccgat gcccttatgt gggggcagat     360

cgcttcgact gcccccactg ggacaatgcc tcccaggccg atcaaggatc cttttatgtc     420

aatcatcaga ttttattcct gcatcttaaa caatgtcatg gaattttcac tctaacctgg     480

gagatatggg gatatgatcc cctgatcacc ttttctttac ataagatccc tgatccccct     540

caacccgact ttccccagtt gaacagtgac tgggttccct ctgtcagatc atgggccctg     600

cttttaaacc aaacagcacg ggccttccca gactgtgcta tatgttggga accttcccct     660

ccctgggctc ccgaaatatt agtatataac aaaaccatct ccagctctgg acccggcctc     720

gccctcccgg acgcccaaat cttctgggtc aacacgtcct cgtttaacac cacccaagga     780

tggcaccacc cttcccagag gttgttgttc aatgtttctc aaggcaacgc cttgttatta     840

cctcctatct ccctggttaa tctctctacg gcttcctccg cccctcctac ccgggtcaga     900

cgtagtcccg tcgcagccct gaccttaggc ctagccctgt cagtggggct cactggaatt     960

aatgtggccg tgtctgccct tagccatcag agactcacct ccctgatcca cgttctggag    1020

caagatcagc aacgcttgat cacagcaatt aaccagaccc actataattt gcttaatgtg    1080

gcctctgtgg ttgcccagaa ccgacggggg cttgattggt tgtacatccg gctgggtttt    1140

caaagcctat gtcccacaat taatgagcct tgctgtttcc tgcgcattca aaatgactcc    1200

attatccgcc tcggtgatct ccagcctctc tcgcaaagag tctctacaga ctggcagtgg    1260

ccctggaatt gggatctggg gctcactgcc tgggtgcgag aaaccattca ttctgttcta    1320

agcctgttcc tattagccct ttttttgctc ttcctggccc cctgcctgat aaaatgcttg    1380

acctctcgcc ttttaaagct cctccggcag gctccccact tccctgaaat ctccttaacc    1440

cctaaacccg attctgatta tcaggccttg ctaccatctg caccagagat ctactctcac    1500

ctctcccccg tcaaacccga ttacatcaac ctccgaccct gccct                    1545


<210> 17
<211> 515
<212> PRT
<213> Artificial Sequence


<220> 
<223> Amino acid sequence of BLV envelope

<400> 17
Met Pro Lys Glu Arg Arg Ser Arg Arg Arg Pro Gln Pro Ile Ile Arg 
1               5                   10                  15      
Trp Val Ser Leu Thr Leu Thr Leu Leu Ser Leu Cys Gln Pro Ile Gln 
            20                  25                  30          
Thr Trp Arg Cys Ser Leu Ser Leu Gly Asn Gln Gln Trp Met Thr Thr 
        35                  40                  45              
Tyr Asn Gln Glu Ala Lys Phe Ser Ile Ala Ile Asp Gln Ile Leu Glu 
    50                  55                  60                  
Ala His Asn Gln Ser Pro Phe Cys Pro Arg Ser Pro Arg Tyr Thr Leu 
65                  70                  75                  80  
Asp Phe Val Asn Gly Tyr Pro Lys Ile Tyr Trp Pro Pro Pro Gln Gly 
                85                  90                  95      
Arg Arg Arg Phe Gly Ala Arg Ala Met Val Thr Tyr Asp Cys Glu Pro 
            100                 105                 110         
Arg Cys Pro Tyr Val Gly Ala Asp His Phe Asp Cys Pro His Trp Asp 
        115                 120                 125             
Asn Ala Ser Gln Ala Asp Gln Gly Ser Phe Tyr Val Asn His Gln Ile 
    130                 135                 140                 
Leu Phe Leu His Leu Lys Gln Cys His Gly Ile Phe Thr Leu Thr Trp 
145                 150                 155                 160 
Glu Ile Trp Gly Tyr Asp Pro Leu Ile Thr Phe Ser Leu His Lys Ile 
                165                 170                 175     
Pro Asp Pro Pro Gln Pro Asp Phe Pro Gln Leu Asn Ser Asp Trp Val 
            180                 185                 190         
Pro Ser Val Arg Ser Trp Ala Leu Leu Leu Asn Gln Thr Ala Arg Ala 
        195                 200                 205             
Phe Pro Asp Cys Ala Ile Cys Trp Glu Pro Ser Pro Pro Trp Ala Pro 
    210                 215                 220                 
Glu Ile Leu Val Tyr Asn Lys Thr Ile Ser Asn Ser Gly Pro Gly Leu 
225                 230                 235                 240 
Ala Leu Pro Asp Ala Gln Ile Phe Trp Val Asn Thr Ser Leu Phe Asn 
                245                 250                 255     
Thr Thr Gln Gly Trp His His Pro Ser Gln Arg Leu Leu Phe Asn Val 
            260                 265                 270         
Ser Gln Gly Asn Ala Leu Leu Leu Pro Pro Ile Ser Leu Val Asn Leu 
        275                 280                 285             
Ser Thr Ala Ser Ser Ala Pro Pro Thr Arg Val Arg Arg Ser Pro Ala 
    290                 295                 300                 
Ala Ala Leu Thr Leu Gly Leu Ala Leu Ser Val Gly Leu Thr Gly Ile 
305                 310                 315                 320 
Asn Val Ala Val Ser Ala Leu Ser His Gln Arg Leu Thr Ser Leu Ile 
                325                 330                 335     
His Val Leu Glu Gln Asp Gln Gln Arg Leu Ile Thr Ala Ile Asn Gln 
            340                 345                 350         
Thr His Tyr Asn Leu Leu Asn Val Ala Ser Val Val Ala Gln Asn Arg 
        355                 360                 365             
Arg Gly Leu Asp Trp Leu Tyr Ile Arg Leu Gly Phe Gln Ser Leu Cys 
    370                 375                 380                 
Pro Thr Ile Asn Glu Pro Cys Cys Phe Leu Arg Ile Gln Asn Asp Ser 
385                 390                 395                 400 
Ile Ile Arg Leu Gly Asp Leu Gln Pro Leu Ser Gln Arg Val Ser Thr 
                405                 410                 415     
Asp Trp Gln Trp Pro Trp Asn Trp Asp Leu Gly Leu Thr Ala Trp Val 
            420                 425                 430         
Arg Glu Thr Ile His Ser Val Leu Ser Leu Phe Leu Leu Ala Leu Phe 
        435                 440                 445             
Leu Leu Phe Leu Ala Pro Cys Leu Ile Lys Cys Leu Thr Ser Arg Leu 
    450                 455                 460                 
Leu Lys Leu Leu Arg Gln Ala Pro His Phe Pro Glu Ile Ser Leu Ala 
465                 470                 475                 480 
Pro Lys Pro Asp Ser Asp Tyr Gln Ala Leu Leu Pro Ser Ala Pro Glu 
                485                 490                 495     
Ile Tyr Ser His Leu Ser Pro Thr Lys Pro Asp Tyr Ile Asn Leu Arg 
            500                 505                 510         
Pro Cys Pro 
        515 

<210> 18
<211> 1545
<212> DNA
<213> Artificial Sequence


<220> 
<223> Nucleic acid sequence of BLV envelope

<400> 18
atgcccaaag aacgacggtc ccgaagacgc ccacaaccga tcatcagatg ggtaagtctc      60

actcttactc tcctctctct ctgtcagccc atccagactt ggagatgctc cctgtcccta     120

ggaaatcaac aatggatgac aacatataac caagaggcaa aattttccat cgccattgac     180

caaatactag aggctcataa tcaatcgcct ttctgtccca ggtctcccag atacaccttg     240

gactttgtaa atggttatcc taagatctat tggccccccc cacaagggcg acgccggttt     300

ggagccaggg ccatggtcac atatgattgc gagccccgat gcccttatgt gggggcagat     360

cacttcgact gcccccactg ggacaatgct tcccaggccg atcaagggtc cttttatgtc     420

aatcatcaga ttttattcct gcatctcaaa caatgtcatg gaattttcac tctaacctgg     480

gaaatatggg gatatgatcc cctgatcacc ttttctttac ataaaatccc tgatccccct     540

caacccgact tccctcagct gaacagtgac tgggttccct ctgtcaggtc atgggccctg     600

cttttaaatc aaacggcacg ggccttccca gactgtgcta tatgttggga accttcccct     660

ccctgggctc ccgaaatatt agtatataac aaaaccatct ccaactctgg acccggtctc     720

gccctcccgg acgcccaaat cttctgggtc aacacgtcct tgtttaacac cacccaagga     780

tggcaccacc cttcccagag gttgttgttc aacgtttctc aaggcaacgc cttattatta     840

ccccctatct ccctggttaa tctctctacg gcttcctccg cccctcctac ccgggtcaga     900

cgcagtcctg ccgcagccct gaccttgggc ctagccctgt cagtggggct cactggaatt     960

aatgtagccg tgtccgccct tagccatcag agactcacct ccctgatcca cgttctggag    1020

caagatcagc aacgcttgat cacagcaatt aaccagaccc actataattt gcttaatgtg    1080

gcctctgtgg tcgcccagaa ccgacggggg cttgattggt tgtacatccg gctgggtttt    1140

caaagcctat gtcccacgat caatgaacct tgctgtttcc tgcgcattca aaatgactcc    1200

attatccgcc tcggtgatct ccagcctctc tcgcaaagag tctctacaga ctggcaatgg    1260

ccctggaatt gggatctggg gctcaccgcc tgggtgcgag aaaccattca ttctgttcta    1320

agcctattcc tattagccct ttttttgctc ttcttggccc cctgcctgat aaaatgcttg    1380

acctctcgcc ttttaaaact cctccggcag gctccccact tccctgaaat ctccttggcc    1440

cctaaacccg attctgatta tcaggccttg ctaccatccg cgccagagat ctactctcac    1500

ctctccccca ccaaacccga ttacatcaac cttcgaccct gccct                    1545


<210> 19
<211> 515
<212> PRT
<213> Artificial Sequence


<220> 
<223> Amino acid sequence of BLV envelope

<400> 19
Met Pro Lys Glu Arg Arg Ser Arg Arg Arg Pro Gln Pro Ile Ile Arg 
1               5                   10                  15      
Trp Val Ser Leu Thr Leu Thr Leu Leu Ala Leu Cys Arg Pro Ile Gln 
            20                  25                  30          
Thr Trp Arg Cys Ser Leu Ser Leu Gly Asn Gln Gln Trp Met Thr Ala 
        35                  40                  45              
Tyr Asn Gln Glu Ala Lys Phe Ser Ile Ser Ile Asp Gln Ile Leu Glu 
    50                  55                  60                  
Ala His Asn Gln Ser Pro Phe Cys Ala Lys Ser Pro Arg Tyr Thr Leu 
65                  70                  75                  80  
Asp Ser Val Asn Gly Tyr Pro Lys Ile Tyr Trp Pro Pro Pro Lys Gly 
                85                  90                  95      
Arg Arg Arg Phe Gly Ala Arg Ala Met Val Thr Tyr Asp Cys Glu Pro 
            100                 105                 110         
Arg Cys Pro Tyr Val Gly Ala Asp Arg Phe Asp Cys Pro His Trp Asp 
        115                 120                 125             
Asn Ala Ser Gln Ala Asp Gln Gly Ser Phe Tyr Val Asn His Gln Ile 
    130                 135                 140                 
Leu Phe Leu His Leu Lys Gln Cys His Gly Ile Phe Thr Leu Thr Trp 
145                 150                 155                 160 
Glu Ile Trp Gly Tyr Asp Pro Leu Ile Thr Phe Ser Leu His Lys Ile 
                165                 170                 175     
Pro Asp Pro Pro Gln Pro Asp Phe Pro Gln Leu Asn Ser Asp Trp Val 
            180                 185                 190         
Pro Ser Val Arg Ser Trp Ala Leu Leu Leu Asn Gln Thr Ala Arg Ala 
        195                 200                 205             
Phe Pro Asp Cys Ala Ile Cys Trp Glu Pro Ser Pro Pro Trp Ala Pro 
    210                 215                 220                 
Glu Ile Leu Val Tyr Asn Lys Thr Ile Ser Ser Ser Gly Pro Gly Leu 
225                 230                 235                 240 
Ala Leu Pro Asp Ala Gln Ile Phe Trp Val Asn Thr Ser Ser Phe Asn 
                245                 250                 255     
Thr Thr Gln Gly Trp His His Pro Ser Gln Arg Leu Leu Phe Asn Val 
            260                 265                 270         
Ser Gln Gly Asn Ala Leu Leu Leu Pro Pro Ile Ser Leu Val Asn Leu 
        275                 280                 285             
Ser Thr Ala Ser Ser Ala Pro Pro Thr Arg Val Arg Arg Ser Pro Val 
    290                 295                 300                 
Ala Ala Leu Thr Leu Gly Leu Ala Leu Ser Val Gly Leu Thr Gly Ile 
305                 310                 315                 320 
Asn Val Ala Val Ser Ala Leu Ser His Gln Arg Leu Thr Ser Leu Ile 
                325                 330                 335     
His Val Leu Glu Gln Asp Gln Gln Arg Leu Ile Thr Ala Ile Asn Gln 
            340                 345                 350         
Thr His Tyr Asn Leu Leu Asn Val Ala Ser Val Val Ala Gln Asn Arg 
        355                 360                 365             
Arg Gly Leu Asp Trp Leu Tyr Ile Arg Leu Gly Phe Gln Ser Leu Cys 
    370                 375                 380                 
Pro Thr Ile Asn Glu Pro Cys Cys Phe Leu Arg Ile Gln Asn Asp Ser 
385                 390                 395                 400 
Ile Ile Arg Leu Gly Asp Leu Gln Pro Leu Ser Gln Arg Val Ser Thr 
                405                 410                 415     
Asp Trp Gln Trp Pro Trp Asn Trp Asp Leu Gly Leu Thr Ala Trp Val 
            420                 425                 430         
Arg Glu Thr Ile His Ser Val Leu Ser Leu Phe Leu Leu Ala Leu Phe 
        435                 440                 445             
Leu Leu Phe Leu Ala Pro Cys Leu Ile Lys Cys Leu Thr Ser Arg Leu 
    450                 455                 460                 
Leu Lys Leu Leu Arg Gln Ala Pro His Phe Pro Glu Ile Ser Leu Thr 
465                 470                 475                 480 
Pro Lys Pro Asp Ser Asp Tyr Gln Ala Leu Leu Pro Ser Ala Pro Glu 
                485                 490                 495     
Ile Tyr Ser His Leu Ser Pro Val Lys Pro Asp Tyr Ile Asn Leu Arg 
            500                 505                 510         
Pro Cys Pro 
        515 

<210> 20
<211> 1545
<212> DNA
<213> Artificial Sequence


<220> 
<223> Nucleic acid sequence BLV envelope

<400> 20
atgcctaaag aacgacggtc ccgaagacgc ccacaaccga tcatcagatg ggtaagtctc      60

actctcactc tcctcgctct ctgtcggccc atccagactt ggagatgctc cctgtcccta     120

ggaaaccaac aatggatgac agcatataac caagaggcaa aattttccat ctccattgac     180

caaatactag aggctcataa tcagtcacct ttctgtgcca agtctcccag atacaccttg     240

gactctgtaa atggctatcc taagatctac tggccccccc caaaagggcg gcgccggttt     300

ggagccaggg ccatggtcac atatgattgc gagccccgat gcccttatgt gggggcagat     360

cgcttcgact gcccccactg ggacaatgcc tcccaggccg atcaaggatc cttttatgtc     420

aatcatcaga ttttattcct gcatctcaaa caatgtcatg gaattttcac cctaacctgg     480

gagatatggg gatatgatcc cctgatcacc ttttctttac ataagattcc tgatccccct     540

caacccgact ttccccagtt gaacagtgac tgggttccct ctgtcagatc atgggccctg     600

cttttaaatc aaacagcacg ggccttccca gactgtgcta tatgttggga accttcccct     660

ccctgggctc ccgaaatatt agtatataac aaaaccatct ccagctctgg acccggcctc     720

gccctcccgg acgcccaaat cttctgggtc aacacgtcct cgtttaacac cacccaagga     780

tggcaccacc cttcccagag gttgttgttc aatgtttctc aaggcaacgc cttgttatta     840

cctcctatct ccctggttaa tctctctacg gcttcctccg cccctcctac ccgggtcaga     900

cgtagtcccg tcgcagccct gaccttaggc ctagccctgt cagtggggct cactggaatt     960

aatgtggccg tgtctgccct tagccatcag agactcacct ccctgatcca cgttctggag    1020

caggatcagc aacgcttgat cacagcaatt aaccagaccc actataattt gcttaatgtg    1080

gcctctgtgg ttgcccagaa ccgacggggg cttgattggt tgtacatccg gctgggtttt    1140

caaagcctat gtcccacaat taatgagcct tgctgtttcc tgcgcattca aaatgactcc    1200

attatccgcc tcggtgatct ccagcctctc tcgcaaagag tctctacaga ctggcagtgg    1260

ccctggaatt gggatctggg gctcactgcc tgggtgcgag aaaccattca ttctgttcta    1320

agcctgttcc tattagccct ttttttgctc ttcctggccc cctgcctgat aaaatgcttg    1380

acctctcgcc ttttaaagct cctccggcag gctccccact tccctgaaat ctccttaacc    1440

cctaaacccg attctgacta tcaggccttg ctaccatctg caccagagat ctactctcac    1500

ctctcccccg tcaaacccga ttacatcaac ctccgaccct gccct                    1545


<210> 21
<211> 181
<212> PRT
<213> Artificial Sequence


<220> 
<223> BLV.RBD

<400> 21
Met Pro Lys Glu Arg Arg Ser Arg Arg Arg Pro Gln Pro Ile Ile Arg 
1               5                   10                  15      
Trp Ile Ser Leu Thr Leu Thr Leu Leu Ala Leu Cys Gln Pro Ile Gln 
            20                  25                  30          
Thr Trp Arg Cys Ser Leu Ser Leu Gly Asn Gln Gln Trp Met Thr Thr 
        35                  40                  45              
Tyr Asn Gln Glu Ala Lys Phe Phe Ile Ser Ile Asp Gln Ile Leu Glu 
    50                  55                  60                  
Ala His Asn Gln Ser Pro Phe Cys Pro Arg Ser Pro Arg Tyr Thr Leu 
65                  70                  75                  80  
Asp Phe Val Asn Gly Tyr Pro Lys Ile Tyr Trp Pro Pro Pro Gln Gly 
                85                  90                  95      
Arg Arg Arg Phe Gly Ala Arg Ala Met Val Thr Tyr Asp Cys Glu Pro 
            100                 105                 110         
Arg Cys Pro Tyr Val Gly Ala Asp His Phe Asp Cys Pro His Trp Asp 
        115                 120                 125             
Asn Ala Ser Gln Ala Asp Gln Gly Ser Phe Tyr Val Asn His Gln Thr 
    130                 135                 140                 
Leu Phe Leu His Leu Lys Gln Cys His Gly Ile Phe Thr Leu Thr Trp 
145                 150                 155                 160 
Glu Ile Trp Gly Tyr Asp Pro Leu Ile Thr Phe Ser Leu His Lys Ile 
                165                 170                 175     
Pro Ala Pro Pro Gln 
            180     

<210> 22
<211> 543
<212> DNA
<213> Artificial Sequence


<220> 
<223> BLV.RBD

<400> 22
atgcccaaag aacgacggtc ccgaagacgc ccacaaccga tcatcagatg gatctccctc      60

actcttactc tcctcgctct ctgtcagccc atccagactt ggagatgctc cctgtcccta     120

ggaaatcaac aatggatgac aacatataac caagaggcaa aatttttcat ctccattgac     180

caaatactag aggctcataa tcaatcacct ttctgtccca ggtctcccag atacaccttg     240

gactttgtaa atggttatcc taagatctat tggccccccc cacaagggcg gcgccggttt     300

ggagccaggg ccatggtcac atatgattgc gagccccgat gcccttatgt gggggcagat     360

cacttcgact gcccccactg ggacaatgcc tcccaggccg atcaaggatc cttttatgtc     420

aatcatcaga ctttattcct gcatctcaaa caatgtcatg gaattttcac tctaacctgg     480

gaaatatggg gatatgatcc cctgatcact ttttctttac ataaaatccc tgctccgcca     540

caa                                                                   543


<210> 23
<211> 622
<212> PRT
<213> Mus musculus


<220> 
<223> CAT1 amino acid sequence

<400> 23
Met Gly Cys Lys Asn Leu Leu Gly Leu Gly Gln Gln Met Leu Arg Arg 
1               5                   10                  15      
Lys Val Val Asp Cys Ser Arg Glu Glu Ser Arg Leu Ser Arg Cys Leu 
            20                  25                  30          
Asn Thr Tyr Asp Leu Val Ala Leu Gly Val Gly Ser Thr Leu Gly Ala 
        35                  40                  45              
Gly Val Tyr Val Leu Ala Gly Ala Val Ala Arg Glu Asn Ala Gly Pro 
    50                  55                  60                  
Ala Ile Val Ile Ser Phe Leu Ile Ala Ala Leu Ala Ser Val Leu Ala 
65                  70                  75                  80  
Gly Leu Cys Tyr Gly Glu Phe Gly Ala Arg Val Pro Lys Thr Gly Ser 
                85                  90                  95      
Ala Tyr Leu Tyr Ser Tyr Val Thr Val Gly Glu Leu Trp Ala Phe Ile 
            100                 105                 110         
Thr Gly Trp Asn Leu Ile Leu Ser Tyr Ile Ile Gly Thr Ser Ser Val 
        115                 120                 125             
Ala Arg Ala Trp Ser Ala Thr Phe Asp Glu Leu Ile Gly Lys Pro Ile 
    130                 135                 140                 
Gly Glu Phe Ser Arg Gln His Met Ala Leu Asn Ala Pro Gly Val Leu 
145                 150                 155                 160 
Ala Gln Thr Pro Asp Ile Phe Ala Val Ile Ile Ile Ile Ile Leu Thr 
                165                 170                 175     
Gly Leu Leu Thr Leu Gly Val Lys Glu Ser Ala Met Val Asn Lys Ile 
            180                 185                 190         
Phe Thr Cys Ile Asn Val Leu Val Leu Cys Phe Ile Val Val Ser Gly 
        195                 200                 205             
Phe Val Lys Gly Ser Ile Lys Asn Trp Gln Leu Thr Glu Lys Asn Phe 
    210                 215                 220                 
Ser Cys Asn Asn Asn Asp Thr Asn Val Lys Tyr Gly Glu Gly Gly Phe 
225                 230                 235                 240 
Met Pro Phe Gly Phe Ser Gly Val Leu Ser Gly Ala Ala Thr Cys Phe 
                245                 250                 255     
Tyr Ala Phe Val Gly Phe Asp Cys Ile Ala Thr Thr Gly Glu Glu Val 
            260                 265                 270         
Lys Asn Pro Gln Lys Ala Ile Pro Val Gly Ile Val Ala Ser Leu Leu 
        275                 280                 285             
Ile Cys Phe Ile Ala Tyr Phe Gly Val Ser Ala Ala Leu Thr Leu Met 
    290                 295                 300                 
Met Pro Tyr Phe Cys Leu Asp Ile Asp Ser Pro Leu Pro Gly Ala Phe 
305                 310                 315                 320 
Lys His Gln Gly Trp Glu Glu Ala Lys Tyr Ala Val Ala Ile Gly Ser 
                325                 330                 335     
Leu Cys Ala Leu Ser Thr Ser Leu Leu Gly Ser Met Phe Pro Met Pro 
            340                 345                 350         
Arg Val Ile Tyr Ala Met Ala Glu Asp Gly Leu Leu Phe Lys Phe Leu 
        355                 360                 365             
Ala Lys Ile Asn Asn Arg Thr Lys Thr Pro Val Ile Ala Thr Val Thr 
    370                 375                 380                 
Ser Gly Ala Ile Ala Ala Val Met Ala Phe Leu Phe Glu Leu Lys Asp 
385                 390                 395                 400 
Leu Val Asp Leu Met Ser Ile Gly Thr Leu Leu Ala Tyr Ser Leu Val 
                405                 410                 415     
Ala Ala Cys Val Leu Val Leu Arg Tyr Gln Pro Glu Gln Pro Asn Leu 
            420                 425                 430         
Val Tyr Gln Met Ala Arg Thr Thr Glu Glu Leu Asp Arg Val Asp Gln 
        435                 440                 445             
Asn Glu Leu Val Ser Ala Ser Glu Ser Gln Thr Gly Phe Leu Pro Val 
    450                 455                 460                 
Ala Glu Lys Phe Ser Leu Lys Ser Ile Leu Ser Pro Lys Asn Val Glu 
465                 470                 475                 480 
Pro Ser Lys Phe Ser Gly Leu Ile Val Asn Ile Ser Ala Gly Leu Leu 
                485                 490                 495     
Ala Ala Leu Ile Ile Thr Val Cys Ile Val Ala Val Leu Gly Arg Glu 
            500                 505                 510         
Ala Leu Ala Glu Gly Thr Leu Trp Ala Val Phe Val Met Thr Gly Ser 
        515                 520                 525             
Val Leu Leu Cys Met Leu Val Thr Gly Ile Ile Trp Arg Gln Pro Glu 
    530                 535                 540                 
Ser Lys Thr Lys Leu Ser Phe Lys Val Pro Phe Val Pro Val Leu Pro 
545                 550                 555                 560 
Val Leu Ser Ile Phe Val Asn Ile Tyr Leu Met Met Gln Leu Asp Gln 
                565                 570                 575     
Gly Thr Trp Val Arg Phe Ala Val Trp Met Leu Ile Gly Phe Thr Ile 
            580                 585                 590         
Tyr Phe Gly Tyr Gly Ile Trp His Ser Glu Glu Ala Ser Leu Ala Ala 
        595                 600                 605             
Gly Gln Ala Lys Thr Pro Asp Ser Asn Leu Asp Gln Cys Lys 
    610                 615                 620         

<210> 24
<211> 624
<212> PRT
<213> Rattus norvegicus


<220> 
<223> CAT1 amino acid sequence

<400> 24
Met Gly Cys Lys Asn Leu Leu Ser Leu Gly Gln Gln Met Leu Arg Arg 
1               5                   10                  15      
Lys Val Val Asp Cys Ser Arg Glu Glu Ser Arg Leu Ser Arg Cys Leu 
            20                  25                  30          
Asn Thr Tyr Asp Leu Val Ala Leu Gly Val Gly Ser Thr Leu Gly Ala 
        35                  40                  45              
Gly Val Tyr Val Leu Ala Gly Ala Val Ala Arg Glu Asn Ala Gly Pro 
    50                  55                  60                  
Ala Ile Val Ile Ser Phe Leu Ile Ala Ala Leu Ala Ser Val Leu Ala 
65                  70                  75                  80  
Gly Leu Cys Tyr Gly Glu Phe Gly Ala Arg Val Pro Lys Thr Gly Ser 
                85                  90                  95      
Ala Tyr Leu Tyr Ser Tyr Val Thr Val Gly Glu Leu Trp Ala Phe Ile 
            100                 105                 110         
Thr Gly Trp Asn Leu Ile Leu Ser Tyr Ile Ile Gly Thr Ser Ser Val 
        115                 120                 125             
Ala Arg Ala Trp Ser Ala Thr Phe Asp Glu Leu Ile Gly Lys Pro Ile 
    130                 135                 140                 
Gly Glu Phe Ser Arg Gln His Met Ala Leu Asn Ala Pro Gly Val Leu 
145                 150                 155                 160 
Ala Gln Thr Pro Asp Ile Phe Ala Val Ile Ile Ile Ile Ile Leu Thr 
                165                 170                 175     
Gly Leu Leu Thr Leu Gly Val Lys Glu Ser Ala Met Val Asn Lys Ile 
            180                 185                 190         
Phe Thr Cys Ile Asn Val Leu Val Leu Cys Phe Ile Met Val Ser Gly 
        195                 200                 205             
Phe Val Lys Gly Ser Ile Glu Asn Trp Gln Leu Thr Glu Asn Lys Ser 
    210                 215                 220                 
Ser Pro Leu Cys Gly Asn Asn Asp Thr Asn Val Lys Tyr Gly Glu Gly 
225                 230                 235                 240 
Gly Phe Met Pro Phe Gly Phe Ser Gly Val Leu Ser Gly Ala Ala Thr 
                245                 250                 255     
Cys Phe Tyr Ala Phe Val Gly Phe Asp Cys Ile Ala Thr Thr Gly Glu 
            260                 265                 270         
Glu Val Lys Asn Pro Gln Lys Ala Ile Pro Val Gly Ile Val Ala Ser 
        275                 280                 285             
Leu Leu Ile Cys Phe Ile Ala Tyr Phe Gly Val Ser Ala Ala Leu Thr 
    290                 295                 300                 
Leu Met Met Pro Tyr Phe Cys Leu Asp Thr Asp Ser Pro Leu Pro Gly 
305                 310                 315                 320 
Ala Phe Lys Tyr Arg Gly Trp Glu Glu Ala Lys Tyr Ala Val Ala Val 
                325                 330                 335     
Gly Ser Leu Cys Ala Leu Ser Thr Ser Pro Leu Gly Ser Met Phe Pro 
            340                 345                 350         
Met Pro Arg Val Ile Tyr Ala Met Ala Glu Asp Gly Leu Leu Phe Lys 
        355                 360                 365             
Phe Leu Ala Lys Ile Asn Asp Arg Thr Lys Thr Pro Ile Ile Ala Thr 
    370                 375                 380                 
Val Thr Ser Gly Ala Ile Ala Ala Val Met Ala Phe Leu Phe Glu Leu 
385                 390                 395                 400 
Lys Asp Leu Val Asp Leu Met Ser Ile Gly Thr Leu Leu Ala Tyr Ser 
                405                 410                 415     
Leu Val Ala Ala Cys Val Leu Val Leu Arg Tyr Gln Pro Glu Gln Pro 
            420                 425                 430         
Asn Leu Val Tyr Gln Met Ala Arg Thr Thr Asp Glu Leu Asp Gln Val 
        435                 440                 445             
Asp Gln Asn Glu Met Val Ser Ala Ser Glu Ser Gln Thr Gly Phe Leu 
    450                 455                 460                 
Pro Ala Ala Glu Lys Phe Ser Leu Lys Thr Ile Leu Ser Pro Lys Asn 
465                 470                 475                 480 
Met Glu Pro Ser Lys Phe Ser Gly Leu Ile Val Asn Ile Ser Ala Gly 
                485                 490                 495     
Leu Leu Ala Val Leu Ile Ile Thr Val Cys Ile Val Ala Val Leu Gly 
            500                 505                 510         
Arg Glu Ala Leu Ala Glu Gly Thr Leu Trp Ala Val Phe Val Met Thr 
        515                 520                 525             
Gly Ser Val Leu Leu Cys Met Leu Val Thr Gly Ile Ile Trp Arg Gln 
    530                 535                 540                 
Pro Glu Ser Lys Thr Lys Leu Ser Phe Lys Val Pro Phe Val Pro Val 
545                 550                 555                 560 
Leu Pro Val Leu Ser Ile Phe Val Asn Ile Tyr Leu Met Met Gln Leu 
                565                 570                 575     
Asp Gln Gly Thr Trp Val Arg Phe Ala Val Trp Met Leu Ile Ala Phe 
            580                 585                 590         
Ala Ile Tyr Phe Gly Tyr Gly Val Trp His Ser Glu Glu Ala Ser Leu 
        595                 600                 605             
Ala Ala Gly Gln Ala Lys Thr Pro Asp Ser Asn Leu Asp Gln Cys Lys 
    610                 615                 620                 



<210> 25
<211> 665
<212> PRT
<213> Moloney murine leukemia virus isolate Shinnick


<220> 
<223> Envelope glycoprotein

<400> 25
Met Ala Arg Ser Thr Leu Ser Lys Pro Leu Lys Asn Lys Val Asn Pro 
1               5                   10                  15      
Arg Gly Pro Leu Ile Pro Leu Ile Leu Leu Met Leu Arg Gly Val Ser 
            20                  25                  30          
Thr Ala Ser Pro Gly Ser Ser Pro His Gln Val Tyr Asn Ile Thr Trp 
        35                  40                  45              
Glu Val Thr Asn Gly Asp Arg Glu Thr Val Trp Ala Thr Ser Gly Asn 
    50                  55                  60                  
His Pro Leu Trp Thr Trp Trp Pro Asp Leu Thr Pro Asp Leu Cys Met 
65                  70                  75                  80  
Leu Ala His His Gly Pro Ser Tyr Trp Gly Leu Glu Tyr Gln Ser Pro 
                85                  90                  95      
Phe Ser Ser Pro Pro Gly Pro Pro Cys Cys Ser Gly Gly Ser Ser Pro 
            100                 105                 110         
Gly Cys Ser Arg Asp Cys Glu Glu Pro Leu Thr Ser Leu Thr Pro Arg 
        115                 120                 125             
Cys Asn Thr Ala Trp Asn Arg Leu Lys Leu Asp Gln Thr Thr His Lys 
    130                 135                 140                 
Ser Asn Glu Gly Phe Tyr Val Cys Pro Gly Pro His Arg Pro Arg Glu 
145                 150                 155                 160 
Ser Lys Ser Cys Gly Gly Pro Asp Ser Phe Tyr Cys Ala Tyr Trp Gly 
                165                 170                 175     
Cys Glu Thr Thr Gly Arg Ala Tyr Trp Lys Pro Ser Ser Ser Trp Asp 
            180                 185                 190         
Phe Ile Thr Val Asn Asn Asn Leu Thr Ser Asp Gln Ala Val Gln Val 
        195                 200                 205             
Cys Lys Asp Asn Lys Trp Cys Asn Pro Leu Val Ile Arg Phe Thr Asp 
    210                 215                 220                 
Ala Gly Arg Arg Val Thr Ser Trp Thr Thr Gly His Tyr Trp Gly Leu 
225                 230                 235                 240 
Arg Leu Tyr Val Ser Gly Gln Asp Pro Gly Leu Thr Phe Gly Ile Arg 
                245                 250                 255     
Leu Arg Tyr Gln Asn Leu Gly Pro Arg Val Pro Ile Gly Pro Asn Pro 
            260                 265                 270         
Val Leu Ala Asp Gln Gln Pro Leu Ser Lys Pro Lys Pro Val Lys Ser 
        275                 280                 285             
Pro Ser Val Thr Lys Pro Pro Ser Gly Thr Pro Leu Ser Pro Thr Gln 
    290                 295                 300                 
Leu Pro Pro Ala Gly Thr Glu Asn Arg Leu Leu Asn Leu Val Asp Gly 
305                 310                 315                 320 
Ala Tyr Gln Ala Leu Asn Leu Thr Ser Pro Asp Lys Thr Gln Glu Cys 
                325                 330                 335     
Trp Leu Cys Leu Val Ala Gly Pro Pro Tyr Tyr Glu Gly Val Ala Val 
            340                 345                 350         
Leu Gly Thr Tyr Ser Asn His Thr Ser Ala Pro Ala Asn Cys Ser Val 
        355                 360                 365             
Ala Ser Gln His Lys Leu Thr Leu Ser Glu Val Thr Gly Gln Gly Leu 
    370                 375                 380                 
Cys Ile Gly Ala Val Pro Lys Thr His Gln Ala Leu Cys Asn Thr Thr 
385                 390                 395                 400 
Gln Thr Ser Ser Arg Gly Ser Tyr Tyr Leu Val Ala Pro Thr Gly Thr 
                405                 410                 415     
Met Trp Ala Cys Ser Thr Gly Leu Thr Pro Cys Ile Ser Thr Thr Ile 
            420                 425                 430         
Leu Asn Leu Thr Thr Asp Tyr Cys Val Leu Val Glu Leu Trp Pro Arg 
        435                 440                 445             
Val Thr Tyr His Ser Pro Ser Tyr Val Tyr Gly Leu Phe Glu Arg Ser 
    450                 455                 460                 
Asn Arg His Lys Arg Glu Pro Val Ser Leu Thr Leu Ala Leu Leu Leu 
465                 470                 475                 480 
Gly Gly Leu Thr Met Gly Gly Ile Ala Ala Gly Ile Gly Thr Gly Thr 
                485                 490                 495     
Thr Ala Leu Met Ala Thr Gln Gln Phe Gln Gln Leu Gln Ala Ala Val 
            500                 505                 510         
Gln Asp Asp Leu Arg Glu Val Glu Lys Ser Ile Ser Asn Leu Glu Lys 
        515                 520                 525             
Ser Leu Thr Ser Leu Ser Glu Val Val Leu Gln Asn Arg Arg Gly Leu 
    530                 535                 540                 
Asp Leu Leu Phe Leu Lys Glu Gly Gly Leu Cys Ala Ala Leu Lys Glu 
545                 550                 555                 560 
Glu Cys Cys Phe Tyr Ala Asp His Thr Gly Leu Val Arg Asp Ser Met 
                565                 570                 575     
Ala Lys Leu Arg Glu Arg Leu Asn Gln Arg Gln Lys Leu Phe Glu Ser 
            580                 585                 590         
Thr Gln Gly Trp Phe Glu Gly Leu Phe Asn Arg Ser Pro Trp Phe Thr 
        595                 600                 605             
Thr Leu Ile Ser Thr Ile Met Gly Pro Leu Ile Val Leu Leu Met Ile 
    610                 615                 620                 
Leu Leu Phe Gly Pro Cys Ile Leu Asn Arg Leu Val Gln Phe Val Lys 
625                 630                 635                 640 
Asp Arg Ile Ser Val Val Gln Ala Leu Val Leu Thr Gln Gln Tyr His 
                645                 650                 655     
Gln Leu Lys Pro Ile Glu Tyr Glu Pro 
            660                 665 

<210> 26
<211> 675
<212> PRT
<213> Friend murine leukemia virus (ISOLATE 57)


<220> 
<223> Envelope glycoprotein

<400> 26
Met Ala Cys Ser Thr Leu Pro Lys Ser Pro Lys Asp Lys Ile Asp Pro 
1               5                   10                  15      
Arg Asp Leu Leu Ile Pro Leu Ile Leu Phe Leu Ser Leu Lys Gly Ala 
            20                  25                  30          
Arg Ser Ala Ala Pro Gly Ser Ser Pro His Gln Val Tyr Asn Ile Thr 
        35                  40                  45              
Trp Glu Val Thr Asn Gly Asp Arg Glu Thr Val Trp Ala Ile Ser Gly 
    50                  55                  60                  
Asn His Pro Leu Trp Thr Trp Trp Pro Val Leu Thr Pro Asp Leu Cys 
65                  70                  75                  80  
Met Leu Ala Leu Ser Gly Pro Pro His Trp Gly Leu Glu Tyr Gln Ala 
                85                  90                  95      
Pro Tyr Ser Ser Pro Pro Gly Pro Pro Cys Cys Ser Gly Ser Ser Gly 
            100                 105                 110         
Ser Ser Ala Gly Cys Ser Arg Asp Cys Asp Glu Pro Leu Thr Ser Leu 
        115                 120                 125             
Thr Pro Arg Cys Asn Thr Ala Trp Asn Arg Leu Lys Leu Asp Gln Val 
    130                 135                 140                 
Thr His Lys Ser Ser Glu Gly Phe Tyr Val Cys Pro Gly Ser His Arg 
145                 150                 155                 160 
Pro Arg Glu Ala Lys Ser Cys Gly Gly Pro Asp Ser Phe Tyr Cys Ala 
                165                 170                 175     
Ser Trp Gly Cys Glu Thr Thr Gly Arg Val Tyr Trp Lys Pro Ser Ser 
            180                 185                 190         
Ser Trp Asp Tyr Ile Thr Val Asp Asn Asn Leu Thr Thr Ser Gln Ala 
        195                 200                 205             
Val Gln Val Cys Lys Asp Asn Lys Trp Cys Asn Pro Leu Ala Ile Gln 
    210                 215                 220                 
Phe Thr Asn Ala Gly Lys Gln Val Thr Ser Trp Thr Thr Gly His Tyr 
225                 230                 235                 240 
Trp Gly Leu Arg Leu Tyr Val Ser Gly Arg Asp Pro Gly Leu Thr Phe 
                245                 250                 255     
Gly Ile Arg Leu Arg Tyr Gln Asn Leu Gly Pro Arg Val Pro Ile Gly 
            260                 265                 270         
Pro Asn Pro Val Leu Ala Asp Gln Leu Ser Leu Pro Arg Pro Asn Pro 
        275                 280                 285             
Leu Pro Lys Pro Ala Lys Ser Pro Pro Ala Ser Asn Ser Thr Pro Thr 
    290                 295                 300                 
Leu Ile Ser Pro Ser Pro Thr Pro Thr Gln Pro Pro Pro Ala Gly Thr 
305                 310                 315                 320 
Gly Asp Arg Leu Leu Asn Leu Val Gln Gly Ala Tyr Gln Ala Leu Asn 
                325                 330                 335     
Leu Thr Asn Pro Asp Lys Thr Gln Glu Cys Trp Leu Cys Leu Val Ser 
            340                 345                 350         
Gly Pro Pro Tyr Tyr Glu Gly Val Ala Val Leu Gly Thr Tyr Ser Asn 
        355                 360                 365             
His Thr Ser Ala Pro Ala Asn Cys Ser Val Ala Ser Gln His Lys Leu 
    370                 375                 380                 
Thr Leu Ser Glu Val Thr Gly Arg Gly Leu Cys Ile Gly Thr Val Pro 
385                 390                 395                 400 
Lys Thr His Gln Ala Leu Cys Asn Thr Thr Leu Lys Ile Asp Lys Gly 
                405                 410                 415     
Ser Tyr Tyr Leu Val Ala Pro Thr Gly Thr Thr Trp Ala Cys Asn Thr 
            420                 425                 430         
Gly Leu Thr Pro Cys Leu Ser Ala Thr Val Leu Asn Arg Thr Thr Asp 
        435                 440                 445             
Tyr Cys Val Leu Val Glu Leu Trp Pro Arg Val Thr Tyr His Pro Pro 
    450                 455                 460                 
Ser Tyr Val Tyr Ser Gln Phe Glu Lys Ser Tyr Arg His Lys Arg Glu 
465                 470                 475                 480 
Pro Val Ser Leu Thr Leu Ala Leu Leu Leu Gly Gly Leu Thr Met Gly 
                485                 490                 495     
Gly Ile Ala Ala Gly Val Gly Thr Gly Thr Thr Ala Leu Val Ala Thr 
            500                 505                 510         
Gln Gln Phe Gln Gln Leu His Ala Ala Val Gln Asp Asp Leu Lys Glu 
        515                 520                 525             
Val Glu Lys Ser Ile Thr Asn Leu Glu Lys Ser Leu Thr Ser Leu Ser 
    530                 535                 540                 
Glu Val Val Leu Gln Asn Arg Arg Gly Leu Asp Leu Leu Phe Leu Lys 
545                 550                 555                 560 
Glu Gly Gly Leu Cys Ala Ala Leu Lys Glu Glu Cys Cys Phe Tyr Ala 
                565                 570                 575     
Asp His Thr Gly Leu Val Arg Asp Ser Met Ala Lys Leu Arg Glu Arg 
            580                 585                 590         
Leu Thr Gln Arg Gln Lys Leu Phe Glu Ser Ser Gln Gly Trp Phe Glu 
        595                 600                 605             
Gly Leu Phe Asn Arg Ser Pro Trp Phe Thr Thr Leu Ile Ser Thr Ile 
    610                 615                 620                 
Met Gly Pro Leu Ile Ile Leu Leu Leu Ile Leu Leu Phe Gly Pro Cys 
625                 630                 635                 640 
Ile Leu Asn Arg Leu Val Gln Phe Val Lys Asp Arg Ile Ser Val Val 
                645                 650                 655     
Gln Ala Leu Val Leu Thr Gln Gln Tyr His Gln Leu Lys Pro Leu Glu 
            660                 665                 670         
Tyr Glu Pro 
        675 

<210> 27
<211> 412
<212> PRT
<213> Artificial Sequence


<220> 
<223> BLV.RBD tagged with a mouse Fc

<400> 27
Met Pro Lys Glu Arg Arg Ser Arg Arg Arg Pro Gln Pro Ile Ile Arg 
1               5                   10                  15      
Trp Ile Ser Leu Thr Leu Thr Leu Leu Ala Leu Cys Gln Pro Ile Gln 
            20                  25                  30          
Thr Trp Arg Cys Ser Leu Ser Leu Gly Asn Gln Gln Trp Met Thr Thr 
        35                  40                  45              
Tyr Asn Gln Glu Ala Lys Phe Phe Ile Ser Ile Asp Gln Ile Leu Glu 
    50                  55                  60                  
Ala His Asn Gln Ser Pro Phe Cys Pro Arg Ser Pro Arg Tyr Thr Leu 
65                  70                  75                  80  
Asp Phe Val Asn Gly Tyr Pro Lys Ile Tyr Trp Pro Pro Pro Gln Gly 
                85                  90                  95      
Arg Arg Arg Phe Gly Ala Arg Ala Met Val Thr Tyr Asp Cys Glu Pro 
            100                 105                 110         
Arg Cys Pro Tyr Val Gly Ala Asp His Phe Asp Cys Pro His Trp Asp 
        115                 120                 125             
Asn Ala Ser Gln Ala Asp Gln Gly Ser Phe Tyr Val Asn His Gln Thr 
    130                 135                 140                 
Leu Phe Leu His Leu Lys Gln Cys His Gly Ile Phe Thr Leu Thr Trp 
145                 150                 155                 160 
Glu Ile Trp Gly Tyr Asp Pro Leu Ile Thr Phe Ser Leu His Lys Ile 
                165                 170                 175     
Pro Ala Pro Pro Gln Gly Ser Val Asp Val Pro Arg Asp Cys Gly Cys 
            180                 185                 190         
Lys Pro Cys Ile Cys Thr Val Pro Glu Val Ser Ser Val Phe Ile Phe 
        195                 200                 205             
Pro Pro Lys Pro Lys Asp Val Leu Thr Ile Thr Leu Thr Pro Lys Val 
    210                 215                 220                 
Thr Cys Val Val Val Asp Ile Ser Lys Asp Asp Pro Glu Val Gln Phe 
225                 230                 235                 240 
Ser Trp Phe Val Asp Asp Val Glu Val His Thr Ala Gln Thr Gln Pro 
                245                 250                 255     
Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Ser Val Ser Glu Leu Pro 
            260                 265                 270         
Ile Met His Gln Asp Trp Leu Asn Gly Lys Glu Phe Lys Cys Arg Val 
        275                 280                 285             
Asn Ser Ala Ala Phe Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr 
    290                 295                 300                 
Lys Gly Arg Pro Lys Ala Pro Gln Val Tyr Thr Ile Pro Pro Pro Lys 
305                 310                 315                 320 
Glu Gln Met Ala Lys Asp Lys Val Ser Leu Thr Cys Met Ile Thr Asp 
                325                 330                 335     
Phe Phe Pro Glu Asp Ile Thr Val Glu Trp Gln Trp Asn Gly Gln Pro 
            340                 345                 350         
Ala Glu Asn Tyr Lys Asn Thr Gln Pro Ile Met Asp Thr Asp Gly Ser 
        355                 360                 365             
Tyr Phe Val Tyr Ser Lys Leu Asn Val Gln Lys Ser Asn Trp Glu Ala 
    370                 375                 380                 
Gly Asn Thr Phe Thr Cys Ser Val Leu His Glu Gly Leu His Asn His 
385                 390                 395                 400 
His Thr Glu Lys Ser Leu Ser His Ser Pro Gly Lys 
                405                 410         

<210> 28
<211> 181
<212> PRT
<213> Artificial Sequence


<220> 
<223> BLV.RBD

<400> 28
Met Pro Lys Glu Arg Arg Ser Arg Arg Arg Pro Gln Pro Ile Ile Arg 
1               5                   10                  15      
Trp Val Ser Leu Thr Leu Thr Leu Leu Ala Leu Cys Gln Pro Ile Gln 
            20                  25                  30          
Thr Trp Arg Cys Ser Leu Ser Leu Gly Asn Gln Gln Trp Met Thr Thr 
        35                  40                  45              
Tyr Asn Gln Glu Ala Lys Phe Phe Ile Ser Ile Asp Gln Ile Leu Glu 
    50                  55                  60                  
Ala His Asn Gln Ser Pro Phe Cys Pro Arg Ser Pro Arg Tyr Thr Leu 
65                  70                  75                  80  
Asp Phe Val Asn Gly Tyr Pro Lys Ile Tyr Trp Pro Pro Pro Gln Gly 
                85                  90                  95      
Arg Arg Arg Phe Gly Ala Arg Ala Met Val Thr Tyr Asp Cys Glu Pro 
            100                 105                 110         
Arg Cys Pro Tyr Val Gly Ala Asp His Phe Asp Cys Pro His Trp Asp 
        115                 120                 125             
Asn Ala Ser Gln Ala Asp Gln Gly Ser Phe Tyr Val Asn His Gln Thr 
    130                 135                 140                 
Leu Phe Leu His Leu Lys Gln Cys His Gly Ile Phe Thr Leu Thr Trp 
145                 150                 155                 160 
Glu Ile Trp Gly Tyr Asp Pro Leu Ile Thr Phe Ser Leu His Lys Ile 
                165                 170                 175     
Pro Ala Pro Pro Gln 
            180     

<210> 29
<211> 181
<212> PRT
<213> Artificial Sequence


<220> 
<223> BLV.RBD

<400> 29
Met Pro Lys Glu Arg Arg Ser Arg Arg Arg Pro Gln Pro Ile Ile Arg 
1               5                   10                  15      
Trp Ile Ser Leu Thr Leu Thr Leu Leu Ala Leu Cys Gln Pro Ile Gln 
            20                  25                  30          
Thr Trp Arg Cys Ser Leu Ser Leu Gly Asn Gln Gln Trp Met Thr Thr 
        35                  40                  45              
Tyr Asn Gln Glu Ala Lys Phe Phe Ile Ser Ile Asp Gln Ile Leu Glu 
    50                  55                  60                  
Ala His Asn Gln Ser Pro Phe Cys Pro Arg Ser Pro Arg Tyr Thr Leu 
65                  70                  75                  80  
Asp Phe Val Asn Gly Tyr Pro Lys Ile Tyr Trp Pro Pro Pro Gln Gly 
                85                  90                  95      
Arg Arg Arg Phe Gly Ala Arg Ala Met Val Thr Tyr Asp Cys Glu Pro 
            100                 105                 110         
Arg Cys Pro Tyr Val Gly Ala Asp His Phe Asp Cys Pro His Trp Asp 
        115                 120                 125             
Asn Ala Ser Gln Ala Asp Gln Gly Ser Phe Tyr Val Asn His Gln Thr 
    130                 135                 140                 
Leu Phe Leu His Leu Lys Gln Cys His Gly Ile Phe Thr Leu Thr Trp 
145                 150                 155                 160 
Glu Ile Trp Gly Tyr Asp Pro Leu Ile Thr Phe Ser Leu His Lys Ile 
                165                 170                 175     
Pro Asp Pro Pro Gln 
            180     

<210> 30
<211> 215
<212> PRT
<213> Artificial Sequence


<220> 
<223> BLV.RBD

<400> 30
Met Pro Lys Glu Arg Arg Ser Arg Arg Arg Pro Gln Pro Ile Ile Arg 
1               5                   10                  15      
Trp Ile Ser Leu Thr Leu Thr Leu Leu Ala Leu Cys Gln Pro Ile Gln 
            20                  25                  30          
Thr Trp Arg Cys Ser Leu Ser Leu Gly Asn Gln Gln Trp Met Thr Thr 
        35                  40                  45              
Tyr Asn Gln Glu Ala Lys Phe Phe Ile Ser Ile Asp Gln Ile Leu Glu 
    50                  55                  60                  
Ala His Asn Gln Ser Pro Phe Cys Pro Arg Ser Pro Arg Tyr Thr Leu 
65                  70                  75                  80  
Asp Phe Val Asn Gly Tyr Pro Lys Ile Tyr Trp Pro Pro Pro Gln Gly 
                85                  90                  95      
Arg Arg Arg Phe Gly Ala Arg Ala Met Val Thr Tyr Asp Cys Glu Pro 
            100                 105                 110         
Arg Cys Pro Tyr Val Gly Ala Asp His Phe Asp Cys Pro His Trp Asp 
        115                 120                 125             
Asn Ala Ser Gln Ala Asp Gln Gly Ser Phe Tyr Val Asn His Gln Thr 
    130                 135                 140                 
Leu Phe Leu His Leu Lys Gln Cys His Gly Ile Phe Thr Leu Thr Trp 
145                 150                 155                 160 
Glu Ile Trp Gly Tyr Asp Pro Leu Ile Thr Phe Ser Leu His Lys Ile 
                165                 170                 175     
Pro Ala Pro Pro Gln Pro Asp Phe Pro Gln Leu Asn Ser Asp Trp Val 
            180                 185                 190         
Pro Ser Val Arg Ser Trp Ala Leu Leu Leu Asn Gln Thr Ala Arg Ala 
        195                 200                 205             
Phe Pro Asp Cys Ala Ile Cys 
    210                 215 

<210> 31
<211> 215
<212> PRT
<213> Artificial Sequence


<220> 
<223> BLV.RBD

<400> 31
Met Pro Lys Glu Arg Arg Ser Arg Arg Arg Pro Gln Pro Ile Ile Arg 
1               5                   10                  15      
Trp Val Ser Leu Thr Leu Thr Leu Leu Ala Leu Cys Gln Pro Ile Gln 
            20                  25                  30          
Thr Trp Arg Cys Ser Leu Ser Leu Gly Asn Gln Gln Trp Met Thr Thr 
        35                  40                  45              
Tyr Asn Gln Glu Ala Lys Phe Phe Ile Ser Ile Asp Gln Ile Leu Glu 
    50                  55                  60                  
Ala His Asn Gln Ser Pro Phe Cys Pro Arg Ser Pro Arg Tyr Thr Leu 
65                  70                  75                  80  
Asp Phe Val Asn Gly Tyr Pro Lys Ile Tyr Trp Pro Pro Pro Gln Gly 
                85                  90                  95      
Arg Arg Arg Phe Gly Ala Arg Ala Met Val Thr Tyr Asp Cys Glu Pro 
            100                 105                 110         
Arg Cys Pro Tyr Val Gly Ala Asp His Phe Asp Cys Pro His Trp Asp 
        115                 120                 125             
Asn Ala Ser Gln Ala Asp Gln Gly Ser Phe Tyr Val Asn His Gln Thr 
    130                 135                 140                 
Leu Phe Leu His Leu Lys Gln Cys His Gly Ile Phe Thr Leu Thr Trp 
145                 150                 155                 160 
Glu Ile Trp Gly Tyr Asp Pro Leu Ile Thr Phe Ser Leu His Lys Ile 
                165                 170                 175     
Pro Ala Pro Pro Gln Pro Asp Phe Pro Gln Leu Asn Ser Asp Trp Val 
            180                 185                 190         
Pro Ser Val Arg Ser Trp Ala Leu Leu Leu Asn Gln Thr Ala Arg Ala 
        195                 200                 205             
Phe Pro Asp Cys Ala Ile Cys 
    210                 215 

<210> 32
<211> 215
<212> PRT
<213> Artificial Sequence


<220> 
<223> BLV.RBD

<400> 32
Met Pro Lys Glu Arg Arg Ser Arg Arg Arg Pro Gln Pro Ile Ile Arg 
1               5                   10                  15      
Trp Ile Ser Leu Thr Leu Thr Leu Leu Ala Leu Cys Gln Pro Ile Gln 
            20                  25                  30          
Thr Trp Arg Cys Ser Leu Ser Leu Gly Asn Gln Gln Trp Met Thr Thr 
        35                  40                  45              
Tyr Asn Gln Glu Ala Lys Phe Phe Ile Ser Ile Asp Gln Ile Leu Glu 
    50                  55                  60                  
Ala His Asn Gln Ser Pro Phe Cys Pro Arg Ser Pro Arg Tyr Thr Leu 
65                  70                  75                  80  
Asp Phe Val Asn Gly Tyr Pro Lys Ile Tyr Trp Pro Pro Pro Gln Gly 
                85                  90                  95      
Arg Arg Arg Phe Gly Ala Arg Ala Met Val Thr Tyr Asp Cys Glu Pro 
            100                 105                 110         
Arg Cys Pro Tyr Val Gly Ala Asp His Phe Asp Cys Pro His Trp Asp 
        115                 120                 125             
Asn Ala Ser Gln Ala Asp Gln Gly Ser Phe Tyr Val Asn His Gln Thr 
    130                 135                 140                 
Leu Phe Leu His Leu Lys Gln Cys His Gly Ile Phe Thr Leu Thr Trp 
145                 150                 155                 160 
Glu Ile Trp Gly Tyr Asp Pro Leu Ile Thr Phe Ser Leu His Lys Ile 
                165                 170                 175     
Pro Asp Pro Pro Gln Pro Asp Phe Pro Gln Leu Asn Ser Asp Trp Val 
            180                 185                 190         
Pro Ser Val Arg Ser Trp Ala Leu Leu Leu Asn Gln Thr Ala Arg Ala 
        195                 200                 205             
Phe Pro Asp Cys Ala Ile Cys 
    210                 215 

<210> 33
<211> 515
<212> PRT
<213> Artificial Sequence


<220> 
<223> Amino acid sequence of BLV envelope

<400> 33
Met Pro Lys Glu Arg Arg Ser Arg Arg Arg Pro Gln Pro Ile Ile Arg 
1               5                   10                  15      
Trp Ile Ser Leu Thr Leu Thr Leu Leu Ala Leu Cys Gln Pro Ile Gln 
            20                  25                  30          
Thr Trp Arg Cys Ser Leu Ser Leu Gly Asn Gln Gln Trp Met Thr Thr 
        35                  40                  45              
Tyr Asn Gln Glu Ala Lys Phe Phe Ile Ser Ile Asp Gln Ile Leu Glu 
    50                  55                  60                  
Ala His Asn Gln Ser Pro Phe Cys Pro Arg Ser Pro Arg Tyr Thr Leu 
65                  70                  75                  80  
Asp Phe Val Asn Gly Tyr Pro Lys Ile Tyr Trp Pro Pro Pro Gln Gly 
                85                  90                  95      
Arg Arg Arg Phe Gly Ala Arg Ala Met Val Thr Tyr Asp Cys Glu Pro 
            100                 105                 110         
Arg Cys Pro Tyr Val Gly Ala Asp His Phe Asp Cys Pro His Trp Asp 
        115                 120                 125             
Asn Ala Ser Gln Ala Asp Gln Gly Ser Phe Tyr Val Asn His Gln Thr 
    130                 135                 140                 
Leu Phe Leu His Leu Lys Gln Cys His Gly Ile Phe Thr Leu Thr Trp 
145                 150                 155                 160 
Glu Ile Trp Gly Tyr Asp Pro Leu Ile Thr Phe Ser Leu His Lys Ile 
                165                 170                 175     
Pro Ala Pro Pro Gln Pro Asp Phe Pro Gln Leu Asn Ser Asp Trp Val 
            180                 185                 190         
Pro Ser Val Arg Ser Trp Ala Leu Leu Leu Asn Gln Thr Ala Arg Ala 
        195                 200                 205             
Phe Pro Asp Cys Ala Ile Cys Trp Glu Pro Ser Pro Pro Trp Ala Pro 
    210                 215                 220                 
Glu Ile Leu Val Tyr Asn Lys Thr Ile Ser Ser Ser Gly Pro Gly Leu 
225                 230                 235                 240 
Ala Leu Pro Asp Ala Gln Ile Phe Trp Val Asn Thr Ser Leu Phe Asn 
                245                 250                 255     
Thr Thr Gln Gly Trp His His Pro Ser Gln Arg Leu Leu Phe Asn Val 
            260                 265                 270         
Ser Gln Gly Asn Ala Leu Leu Leu Pro Pro Ile Ser Leu Val Asn Leu 
        275                 280                 285             
Ser Thr Ala Ser Ser Ala Pro Pro Thr Arg Val Arg Arg Ser Pro Val 
    290                 295                 300                 
Ala Ala Leu Thr Leu Gly Leu Ala Leu Ser Val Gly Leu Thr Gly Ile 
305                 310                 315                 320 
Asn Val Ala Val Ser Ala Leu Ser His Gln Arg Leu Thr Ser Leu Ile 
                325                 330                 335     
His Val Leu Glu Gln Asp Gln Gln Arg Leu Ile Thr Ala Ile Asn Gln 
            340                 345                 350         
Thr His Tyr Asn Leu Leu Asn Val Ala Ser Val Val Ala Gln Asn Arg 
        355                 360                 365             
Arg Gly Leu Asp Trp Leu Tyr Ile Arg Leu Gly Phe Gln Ser Leu Cys 
    370                 375                 380                 
Pro Thr Ile Asn Glu Pro Cys Cys Phe Leu Arg Ile Gln Asn Asp Ser 
385                 390                 395                 400 
Ile Ile Arg Leu Gly Asp Leu Gln Pro Leu Ser Gln Arg Val Ser Thr 
                405                 410                 415     
Asp Trp Gln Trp Pro Trp Asn Trp Asp Leu Gly Leu Thr Ala Trp Val 
            420                 425                 430         
Arg Glu Thr Ile His Ser Val Leu Ser Leu Phe Leu Leu Ala Leu Phe 
        435                 440                 445             
Leu Leu Phe Leu Ala Pro Cys Leu Ile Lys Cys Leu Thr Ser Arg Leu 
    450                 455                 460                 
Leu Lys Leu Leu Arg Gln Ala Pro His Phe Pro Glu Ile Ser Phe Pro 
465                 470                 475                 480 
Pro Lys Pro Asp Ser Asp Tyr Gln Ala Leu Leu Pro Ser Ala Pro Glu 
                485                 490                 495     
Ile Tyr Ser His Leu Ser Pro Thr Lys Pro Asp Tyr Ile Asn Leu Arg 
            500                 505                 510         
Pro Cys Pro 
        515 

<210> 34
<211> 515
<212> PRT
<213> Artificial Sequence


<220> 
<223> Amino acid sequence of BLV envelope

<400> 34
Met Pro Lys Glu Arg Arg Ser Arg Arg Arg Pro Gln Pro Ile Ile Arg 
1               5                   10                  15      
Trp Val Ser Leu Thr Leu Thr Leu Leu Ala Leu Cys Gln Pro Ile Gln 
            20                  25                  30          
Thr Trp Arg Cys Ser Leu Ser Leu Gly Asn Gln Gln Trp Met Thr Thr 
        35                  40                  45              
Tyr Asn Gln Glu Ala Lys Phe Phe Ile Ser Ile Asp Gln Ile Leu Glu 
    50                  55                  60                  
Ala His Asn Gln Ser Pro Phe Cys Pro Arg Ser Pro Arg Tyr Thr Leu 
65                  70                  75                  80  
Asp Phe Val Asn Gly Tyr Pro Lys Ile Tyr Trp Pro Pro Pro Gln Gly 
                85                  90                  95      
Arg Arg Arg Phe Gly Ala Arg Ala Met Val Thr Tyr Asp Cys Glu Pro 
            100                 105                 110         
Arg Cys Pro Tyr Val Gly Ala Asp His Phe Asp Cys Pro His Trp Asp 
        115                 120                 125             
Asn Ala Ser Gln Ala Asp Gln Gly Ser Phe Tyr Val Asn His Gln Thr 
    130                 135                 140                 
Leu Phe Leu His Leu Lys Gln Cys His Gly Ile Phe Thr Leu Thr Trp 
145                 150                 155                 160 
Glu Ile Trp Gly Tyr Asp Pro Leu Ile Thr Phe Ser Leu His Lys Ile 
                165                 170                 175     
Pro Ala Pro Pro Gln Pro Asp Phe Pro Gln Leu Asn Ser Asp Trp Val 
            180                 185                 190         
Pro Ser Val Arg Ser Trp Ala Leu Leu Leu Asn Gln Thr Ala Arg Ala 
        195                 200                 205             
Phe Pro Asp Cys Ala Ile Cys Trp Glu Pro Ser Pro Pro Trp Ala Pro 
    210                 215                 220                 
Glu Ile Leu Val Tyr Asn Lys Thr Ile Ser Ser Ser Gly Pro Gly Leu 
225                 230                 235                 240 
Ala Leu Pro Asp Ala Gln Ile Phe Trp Val Asn Thr Ser Leu Phe Asn 
                245                 250                 255     
Thr Thr Gln Gly Trp His His Pro Ser Gln Arg Leu Leu Phe Asn Val 
            260                 265                 270         
Ser Gln Gly Asn Ala Leu Leu Leu Pro Pro Ile Ser Leu Val Asn Leu 
        275                 280                 285             
Ser Thr Ala Ser Ser Ala Pro Pro Thr Arg Val Arg Arg Ser Pro Val 
    290                 295                 300                 
Ala Ala Leu Thr Leu Gly Leu Ala Leu Ser Val Gly Leu Thr Gly Ile 
305                 310                 315                 320 
Asn Val Ala Val Ser Ala Leu Ser His Gln Arg Leu Thr Ser Leu Ile 
                325                 330                 335     
His Val Leu Glu Gln Asp Gln Gln Arg Leu Ile Thr Ala Ile Asn Gln 
            340                 345                 350         
Thr His Tyr Asn Leu Leu Asn Val Ala Ser Val Val Ala Gln Asn Arg 
        355                 360                 365             
Arg Gly Leu Asp Trp Leu Tyr Ile Arg Leu Gly Phe Gln Ser Leu Cys 
    370                 375                 380                 
Pro Thr Ile Asn Glu Pro Cys Cys Phe Leu Arg Ile Gln Asn Asp Ser 
385                 390                 395                 400 
Ile Ile Arg Leu Gly Asp Leu Gln Pro Leu Ser Gln Arg Val Ser Thr 
                405                 410                 415     
Asp Trp Gln Trp Pro Trp Asn Trp Asp Leu Gly Leu Thr Ala Trp Val 
            420                 425                 430         
Arg Glu Thr Ile His Ser Val Leu Ser Leu Phe Leu Leu Ala Leu Phe 
        435                 440                 445             
Leu Leu Phe Leu Ala Pro Cys Leu Ile Lys Cys Leu Thr Ser Arg Leu 
    450                 455                 460                 
Leu Lys Leu Leu Arg Gln Ala Pro His Phe Pro Glu Ile Ser Phe Pro 
465                 470                 475                 480 
Pro Lys Pro Asp Ser Asp Tyr Gln Ala Leu Leu Pro Ser Ala Pro Glu 
                485                 490                 495     
Ile Tyr Ser His Leu Ser Pro Thr Lys Pro Asp Tyr Ile Asn Leu Arg 
            500                 505                 510         
Pro Cys Pro 
        515 

<210> 35
<211> 515
<212> PRT
<213> Artificial Sequence


<220> 
<223> Amino acid sequence of BLV envelope

<400> 35
Met Pro Lys Glu Arg Arg Ser Arg Arg Arg Pro Gln Pro Ile Ile Arg 
1               5                   10                  15      
Trp Ile Ser Leu Thr Leu Thr Leu Leu Ala Leu Cys Gln Pro Ile Gln 
            20                  25                  30          
Thr Trp Arg Cys Ser Leu Ser Leu Gly Asn Gln Gln Trp Met Thr Thr 
        35                  40                  45              
Tyr Asn Gln Glu Ala Lys Phe Phe Ile Ser Ile Asp Gln Ile Leu Glu 
    50                  55                  60                  
Ala His Asn Gln Ser Pro Phe Cys Pro Arg Ser Pro Arg Tyr Thr Leu 
65                  70                  75                  80  
Asp Phe Val Asn Gly Tyr Pro Lys Ile Tyr Trp Pro Pro Pro Gln Gly 
                85                  90                  95      
Arg Arg Arg Phe Gly Ala Arg Ala Met Val Thr Tyr Asp Cys Glu Pro 
            100                 105                 110         
Arg Cys Pro Tyr Val Gly Ala Asp His Phe Asp Cys Pro His Trp Asp 
        115                 120                 125             
Asn Ala Ser Gln Ala Asp Gln Gly Ser Phe Tyr Val Asn His Gln Thr 
    130                 135                 140                 
Leu Phe Leu His Leu Lys Gln Cys His Gly Ile Phe Thr Leu Thr Trp 
145                 150                 155                 160 
Glu Ile Trp Gly Tyr Asp Pro Leu Ile Thr Phe Ser Leu His Lys Ile 
                165                 170                 175     
Pro Asp Pro Pro Gln Pro Asp Phe Pro Gln Leu Asn Ser Asp Trp Val 
            180                 185                 190         
Pro Ser Val Arg Ser Trp Ala Leu Leu Leu Asn Gln Thr Ala Arg Ala 
        195                 200                 205             
Phe Pro Asp Cys Ala Ile Cys Trp Glu Pro Ser Pro Pro Trp Ala Pro 
    210                 215                 220                 
Glu Ile Leu Val Tyr Asn Lys Thr Ile Ser Ser Ser Gly Pro Gly Leu 
225                 230                 235                 240 
Ala Leu Pro Asp Ala Gln Ile Phe Trp Val Asn Thr Ser Leu Phe Asn 
                245                 250                 255     
Thr Thr Gln Gly Trp His His Pro Ser Gln Arg Leu Leu Phe Asn Val 
            260                 265                 270         
Ser Gln Gly Asn Ala Leu Leu Leu Pro Pro Ile Ser Leu Val Asn Leu 
        275                 280                 285             
Ser Thr Ala Ser Ser Ala Pro Pro Thr Arg Val Arg Arg Ser Pro Val 
    290                 295                 300                 
Ala Ala Leu Thr Leu Gly Leu Ala Leu Ser Val Gly Leu Thr Gly Ile 
305                 310                 315                 320 
Asn Val Ala Val Ser Ala Leu Ser His Gln Arg Leu Thr Ser Leu Ile 
                325                 330                 335     
His Val Leu Glu Gln Asp Gln Gln Arg Leu Ile Thr Ala Ile Asn Gln 
            340                 345                 350         
Thr His Tyr Asn Leu Leu Asn Val Ala Ser Val Val Ala Gln Asn Arg 
        355                 360                 365             
Arg Gly Leu Asp Trp Leu Tyr Ile Arg Leu Gly Phe Gln Ser Leu Cys 
    370                 375                 380                 
Pro Thr Ile Asn Glu Pro Cys Cys Phe Leu Arg Ile Gln Asn Asp Ser 
385                 390                 395                 400 
Ile Ile Arg Leu Gly Asp Leu Gln Pro Leu Ser Gln Arg Val Ser Thr 
                405                 410                 415     
Asp Trp Gln Trp Pro Trp Asn Trp Asp Leu Gly Leu Thr Ala Trp Val 
            420                 425                 430         
Arg Glu Thr Ile His Ser Val Leu Ser Leu Phe Leu Leu Ala Leu Phe 
        435                 440                 445             
Leu Leu Phe Leu Ala Pro Cys Leu Ile Lys Cys Leu Thr Ser Arg Leu 
    450                 455                 460                 
Leu Lys Leu Leu Arg Gln Ala Pro His Phe Pro Glu Ile Ser Phe Pro 
465                 470                 475                 480 
Pro Lys Pro Asp Ser Asp Tyr Gln Ala Leu Leu Pro Ser Ala Pro Glu 
                485                 490                 495     
Ile Tyr Ser His Leu Ser Pro Thr Lys Pro Asp Tyr Ile Asn Leu Arg 
            500                 505                 510         
Pro Cys Pro 
        515 

<210> 36
<211> 515
<212> PRT
<213> Artificial Sequence


<220> 
<223> Amino acid sequence of BLV envelope

<400> 36
Met Pro Lys Lys Arg Arg Ser Arg Arg Arg Pro Gln Pro Ile Ile Arg 
1               5                   10                  15      
Trp Ile Ser Leu Thr Leu Thr Leu Leu Ala Leu Cys Arg Pro Ile Gln 
            20                  25                  30          
Thr Trp Arg Cys Ser Leu Ser Leu Gly Asn Gln Gln Trp Met Thr Ala 
        35                  40                  45              
Tyr Asn Gln Glu Ala Lys Phe Ser Ile Ser Ile Asp Gln Ile Leu Glu 
    50                  55                  60                  
Ala His Asn Gln Ser Pro Phe Cys Ala Lys Ser Pro Arg Tyr Thr Leu 
65                  70                  75                  80  
Asp Ser Val Asn Gly Tyr Pro Lys Ile Tyr Trp Pro Pro Pro Gln Gly 
                85                  90                  95      
Arg Arg Arg Phe Gly Ala Arg Ala Met Val Thr Tyr Asp Cys Glu Pro 
            100                 105                 110         
Arg Cys Pro Tyr Val Gly Ala Asp Arg Phe Asp Cys Pro His Trp Asp 
        115                 120                 125             
Asn Ala Ser Gln Ala Asp Gln Gly Ser Phe Tyr Val Asn His Gln Ile 
    130                 135                 140                 
Leu Phe Leu His Leu Lys Gln Cys His Gly Ile Phe Thr Leu Thr Trp 
145                 150                 155                 160 
Glu Ile Trp Gly Tyr Asp Pro Leu Ile Thr Phe Ser Leu His Lys Ile 
                165                 170                 175     
Pro Ala Pro Pro Gln Pro Asp Phe Pro Gln Leu Asn Ser Asp Trp Val 
            180                 185                 190         
Pro Ser Val Arg Ser Trp Ala Leu Leu Leu Asn Gln Thr Ala Arg Ala 
        195                 200                 205             
Phe Pro Asp Cys Ala Ile Cys Trp Glu Pro Ser Pro Pro Trp Ala Pro 
    210                 215                 220                 
Glu Ile Leu Val Tyr Asn Lys Thr Ile Ser Ser Ser Gly Pro Gly Leu 
225                 230                 235                 240 
Ala Leu Pro Asp Ala Gln Ile Phe Trp Val Asn Thr Ser Ser Phe Asn 
                245                 250                 255     
Thr Thr Gln Gly Trp His His Pro Ser Gln Arg Leu Leu Phe Asn Val 
            260                 265                 270         
Ser Gln Gly Asn Ala Leu Leu Leu Pro Pro Ile Ser Leu Val Asn Leu 
        275                 280                 285             
Ser Thr Ala Ser Ser Ala Pro Pro Thr Arg Val Arg Arg Ser Pro Val 
    290                 295                 300                 
Ala Ala Leu Thr Leu Gly Leu Ala Leu Ser Val Gly Leu Thr Gly Ile 
305                 310                 315                 320 
Asn Val Ala Val Ser Ala Leu Ser His Gln Arg Leu Thr Ser Leu Ile 
                325                 330                 335     
His Val Leu Glu Gln Asp Gln Gln Arg Leu Ile Thr Ala Ile Asn Gln 
            340                 345                 350         
Thr His Tyr Asn Leu Leu Asn Val Ala Ser Val Val Ala Gln Asn Arg 
        355                 360                 365             
Arg Gly Leu Asp Trp Leu Tyr Ile Arg Leu Gly Phe Gln Ser Leu Cys 
    370                 375                 380                 
Pro Thr Ile Asn Glu Pro Cys Cys Phe Leu Arg Ile Gln Asn Asp Ser 
385                 390                 395                 400 
Ile Ile Arg Leu Gly Asp Leu Gln Pro Leu Ser Gln Arg Val Ser Thr 
                405                 410                 415     
Asp Trp Gln Trp Pro Trp Asn Trp Asp Leu Gly Leu Thr Ala Trp Val 
            420                 425                 430         
Arg Glu Thr Ile His Ser Val Leu Ser Leu Phe Leu Leu Ala Leu Phe 
        435                 440                 445             
Leu Leu Phe Leu Ala Pro Cys Leu Ile Lys Cys Leu Thr Ser Arg Leu 
    450                 455                 460                 
Leu Lys Leu Leu Arg Gln Ala Pro His Phe Pro Glu Ile Ser Leu Thr 
465                 470                 475                 480 
Pro Lys Pro Asp Ser Asp Tyr Gln Ala Leu Leu Pro Ser Ala Pro Glu 
                485                 490                 495     
Ile Tyr Ser His Leu Ser Pro Val Lys Pro Asp Tyr Ile Asn Leu Arg 
            500                 505                 510         
Pro Cys Pro 
        515 

<210> 37
<211> 515
<212> PRT
<213> Artificial Sequence


<220> 
<223> Amino acid sequence of BLV envelope

<400> 37
Met Pro Lys Lys Arg Arg Ser Arg Arg Arg Pro Gln Pro Ile Ile Arg 
1               5                   10                  15      
Trp Val Ser Leu Thr Leu Thr Leu Leu Ala Leu Cys Arg Pro Ile Gln 
            20                  25                  30          
Thr Trp Arg Cys Ser Leu Ser Leu Gly Asn Gln Gln Trp Met Thr Ala 
        35                  40                  45              
Tyr Asn Gln Glu Ala Lys Phe Ser Ile Ser Ile Asp Gln Ile Leu Glu 
    50                  55                  60                  
Ala His Asn Gln Ser Pro Phe Cys Ala Lys Ser Pro Arg Tyr Thr Leu 
65                  70                  75                  80  
Asp Ser Val Asn Gly Tyr Pro Lys Ile Tyr Trp Pro Pro Pro Gln Gly 
                85                  90                  95      
Arg Arg Arg Phe Gly Ala Arg Ala Met Val Thr Tyr Asp Cys Glu Pro 
            100                 105                 110         
Arg Cys Pro Tyr Val Gly Ala Asp Arg Phe Asp Cys Pro His Trp Asp 
        115                 120                 125             
Asn Ala Ser Gln Ala Asp Gln Gly Ser Phe Tyr Val Asn His Gln Ile 
    130                 135                 140                 
Leu Phe Leu His Leu Lys Gln Cys His Gly Ile Phe Thr Leu Thr Trp 
145                 150                 155                 160 
Glu Ile Trp Gly Tyr Asp Pro Leu Ile Thr Phe Ser Leu His Lys Ile 
                165                 170                 175     
Pro Ala Pro Pro Gln Pro Asp Phe Pro Gln Leu Asn Ser Asp Trp Val 
            180                 185                 190         
Pro Ser Val Arg Ser Trp Ala Leu Leu Leu Asn Gln Thr Ala Arg Ala 
        195                 200                 205             
Phe Pro Asp Cys Ala Ile Cys Trp Glu Pro Ser Pro Pro Trp Ala Pro 
    210                 215                 220                 
Glu Ile Leu Val Tyr Asn Lys Thr Ile Ser Ser Ser Gly Pro Gly Leu 
225                 230                 235                 240 
Ala Leu Pro Asp Ala Gln Ile Phe Trp Val Asn Thr Ser Ser Phe Asn 
                245                 250                 255     
Thr Thr Gln Gly Trp His His Pro Ser Gln Arg Leu Leu Phe Asn Val 
            260                 265                 270         
Ser Gln Gly Asn Ala Leu Leu Leu Pro Pro Ile Ser Leu Val Asn Leu 
        275                 280                 285             
Ser Thr Ala Ser Ser Ala Pro Pro Thr Arg Val Arg Arg Ser Pro Val 
    290                 295                 300                 
Ala Ala Leu Thr Leu Gly Leu Ala Leu Ser Val Gly Leu Thr Gly Ile 
305                 310                 315                 320 
Asn Val Ala Val Ser Ala Leu Ser His Gln Arg Leu Thr Ser Leu Ile 
                325                 330                 335     
His Val Leu Glu Gln Asp Gln Gln Arg Leu Ile Thr Ala Ile Asn Gln 
            340                 345                 350         
Thr His Tyr Asn Leu Leu Asn Val Ala Ser Val Val Ala Gln Asn Arg 
        355                 360                 365             
Arg Gly Leu Asp Trp Leu Tyr Ile Arg Leu Gly Phe Gln Ser Leu Cys 
    370                 375                 380                 
Pro Thr Ile Asn Glu Pro Cys Cys Phe Leu Arg Ile Gln Asn Asp Ser 
385                 390                 395                 400 
Ile Ile Arg Leu Gly Asp Leu Gln Pro Leu Ser Gln Arg Val Ser Thr 
                405                 410                 415     
Asp Trp Gln Trp Pro Trp Asn Trp Asp Leu Gly Leu Thr Ala Trp Val 
            420                 425                 430         
Arg Glu Thr Ile His Ser Val Leu Ser Leu Phe Leu Leu Ala Leu Phe 
        435                 440                 445             
Leu Leu Phe Leu Ala Pro Cys Leu Ile Lys Cys Leu Thr Ser Arg Leu 
    450                 455                 460                 
Leu Lys Leu Leu Arg Gln Ala Pro His Phe Pro Glu Ile Ser Leu Thr 
465                 470                 475                 480 
Pro Lys Pro Asp Ser Asp Tyr Gln Ala Leu Leu Pro Ser Ala Pro Glu 
                485                 490                 495     
Ile Tyr Ser His Leu Ser Pro Val Lys Pro Asp Tyr Ile Asn Leu Arg 
            500                 505                 510         
Pro Cys Pro 
        515 

<210> 38
<211> 515
<212> PRT
<213> Artificial Sequence


<220> 
<223> Amino acid sequence of BLV envelope

<400> 38
Met Pro Lys Lys Arg Arg Ser Arg Arg Arg Pro Gln Pro Ile Ile Arg 
1               5                   10                  15      
Trp Ile Ser Leu Thr Leu Thr Leu Leu Ala Leu Cys Arg Pro Ile Gln 
            20                  25                  30          
Thr Trp Arg Cys Ser Leu Ser Leu Gly Asn Gln Gln Trp Met Thr Ala 
        35                  40                  45              
Tyr Asn Gln Glu Ala Lys Phe Ser Ile Ser Ile Asp Gln Ile Leu Glu 
    50                  55                  60                  
Ala His Asn Gln Ser Pro Phe Cys Ala Lys Ser Pro Arg Tyr Thr Leu 
65                  70                  75                  80  
Asp Ser Val Asn Gly Tyr Pro Lys Ile Tyr Trp Pro Pro Pro Gln Gly 
                85                  90                  95      
Arg Arg Arg Phe Gly Ala Arg Ala Met Val Thr Tyr Asp Cys Glu Pro 
            100                 105                 110         
Arg Cys Pro Tyr Val Gly Ala Asp Arg Phe Asp Cys Pro His Trp Asp 
        115                 120                 125             
Asn Ala Ser Gln Ala Asp Gln Gly Ser Phe Tyr Val Asn His Gln Ile 
    130                 135                 140                 
Leu Phe Leu His Leu Lys Gln Cys His Gly Ile Phe Thr Leu Thr Trp 
145                 150                 155                 160 
Glu Ile Trp Gly Tyr Asp Pro Leu Ile Thr Phe Ser Leu His Lys Ile 
                165                 170                 175     
Pro Asp Pro Pro Gln Pro Asp Phe Pro Gln Leu Asn Ser Asp Trp Val 
            180                 185                 190         
Pro Ser Val Arg Ser Trp Ala Leu Leu Leu Asn Gln Thr Ala Arg Ala 
        195                 200                 205             
Phe Pro Asp Cys Ala Ile Cys Trp Glu Pro Ser Pro Pro Trp Ala Pro 
    210                 215                 220                 
Glu Ile Leu Val Tyr Asn Lys Thr Ile Ser Ser Ser Gly Pro Gly Leu 
225                 230                 235                 240 
Ala Leu Pro Asp Ala Gln Ile Phe Trp Val Asn Thr Ser Ser Phe Asn 
                245                 250                 255     
Thr Thr Gln Gly Trp His His Pro Ser Gln Arg Leu Leu Phe Asn Val 
            260                 265                 270         
Ser Gln Gly Asn Ala Leu Leu Leu Pro Pro Ile Ser Leu Val Asn Leu 
        275                 280                 285             
Ser Thr Ala Ser Ser Ala Pro Pro Thr Arg Val Arg Arg Ser Pro Val 
    290                 295                 300                 
Ala Ala Leu Thr Leu Gly Leu Ala Leu Ser Val Gly Leu Thr Gly Ile 
305                 310                 315                 320 
Asn Val Ala Val Ser Ala Leu Ser His Gln Arg Leu Thr Ser Leu Ile 
                325                 330                 335     
His Val Leu Glu Gln Asp Gln Gln Arg Leu Ile Thr Ala Ile Asn Gln 
            340                 345                 350         
Thr His Tyr Asn Leu Leu Asn Val Ala Ser Val Val Ala Gln Asn Arg 
        355                 360                 365             
Arg Gly Leu Asp Trp Leu Tyr Ile Arg Leu Gly Phe Gln Ser Leu Cys 
    370                 375                 380                 
Pro Thr Ile Asn Glu Pro Cys Cys Phe Leu Arg Ile Gln Asn Asp Ser 
385                 390                 395                 400 
Ile Ile Arg Leu Gly Asp Leu Gln Pro Leu Ser Gln Arg Val Ser Thr 
                405                 410                 415     
Asp Trp Gln Trp Pro Trp Asn Trp Asp Leu Gly Leu Thr Ala Trp Val 
            420                 425                 430         
Arg Glu Thr Ile His Ser Val Leu Ser Leu Phe Leu Leu Ala Leu Phe 
        435                 440                 445             
Leu Leu Phe Leu Ala Pro Cys Leu Ile Lys Cys Leu Thr Ser Arg Leu 
    450                 455                 460                 
Leu Lys Leu Leu Arg Gln Ala Pro His Phe Pro Glu Ile Ser Leu Thr 
465                 470                 475                 480 
Pro Lys Pro Asp Ser Asp Tyr Gln Ala Leu Leu Pro Ser Ala Pro Glu 
                485                 490                 495     
Ile Tyr Ser His Leu Ser Pro Val Lys Pro Asp Tyr Ile Asn Leu Arg 
            500                 505                 510         
Pro Cys Pro 
        515 

<210> 39
<211> 515
<212> PRT
<213> Artificial Sequence


<220> 
<223> Amino acid sequence of BLV envelope

<400> 39
Met Pro Lys Glu Arg Arg Ser Arg Arg Arg Pro Gln Pro Ile Ile Arg 
1               5                   10                  15      
Trp Ile Ser Leu Thr Leu Thr Leu Leu Ser Leu Cys Gln Pro Ile Gln 
            20                  25                  30          
Thr Trp Arg Cys Ser Leu Ser Leu Gly Asn Gln Gln Trp Met Thr Thr 
        35                  40                  45              
Tyr Asn Gln Glu Ala Lys Phe Ser Ile Ala Ile Asp Gln Ile Leu Glu 
    50                  55                  60                  
Ala His Asn Gln Ser Pro Phe Cys Pro Arg Ser Pro Arg Tyr Thr Leu 
65                  70                  75                  80  
Asp Phe Val Asn Gly Tyr Pro Lys Ile Tyr Trp Pro Pro Pro Gln Gly 
                85                  90                  95      
Arg Arg Arg Phe Gly Ala Arg Ala Met Val Thr Tyr Asp Cys Glu Pro 
            100                 105                 110         
Arg Cys Pro Tyr Val Gly Ala Asp His Phe Asp Cys Pro His Trp Asp 
        115                 120                 125             
Asn Ala Ser Gln Ala Asp Gln Gly Ser Phe Tyr Val Asn His Gln Ile 
    130                 135                 140                 
Leu Phe Leu His Leu Lys Gln Cys His Gly Ile Phe Thr Leu Thr Trp 
145                 150                 155                 160 
Glu Ile Trp Gly Tyr Asp Pro Leu Ile Thr Phe Ser Leu His Lys Ile 
                165                 170                 175     
Pro Ala Pro Pro Gln Pro Asp Phe Pro Gln Leu Asn Ser Asp Trp Val 
            180                 185                 190         
Pro Ser Val Arg Ser Trp Ala Leu Leu Leu Asn Gln Thr Ala Arg Ala 
        195                 200                 205             
Phe Pro Asp Cys Ala Ile Cys Trp Glu Pro Ser Pro Pro Trp Ala Pro 
    210                 215                 220                 
Glu Ile Leu Val Tyr Asn Lys Thr Ile Ser Asn Ser Gly Pro Gly Leu 
225                 230                 235                 240 
Ala Leu Pro Asp Ala Gln Ile Phe Trp Val Asn Thr Ser Leu Phe Asn 
                245                 250                 255     
Thr Thr Gln Gly Trp His His Pro Ser Gln Arg Leu Leu Phe Asn Val 
            260                 265                 270         
Ser Gln Gly Asn Ala Leu Leu Leu Pro Pro Ile Ser Leu Val Asn Leu 
        275                 280                 285             
Ser Thr Ala Ser Ser Ala Pro Pro Thr Arg Val Arg Arg Ser Pro Ala 
    290                 295                 300                 
Ala Ala Leu Thr Leu Gly Leu Ala Leu Ser Val Gly Leu Thr Gly Ile 
305                 310                 315                 320 
Asn Val Ala Val Ser Ala Leu Ser His Gln Arg Leu Thr Ser Leu Ile 
                325                 330                 335     
His Val Leu Glu Gln Asp Gln Gln Arg Leu Ile Thr Ala Ile Asn Gln 
            340                 345                 350         
Thr His Tyr Asn Leu Leu Asn Val Ala Ser Val Val Ala Gln Asn Arg 
        355                 360                 365             
Arg Gly Leu Asp Trp Leu Tyr Ile Arg Leu Gly Phe Gln Ser Leu Cys 
    370                 375                 380                 
Pro Thr Ile Asn Glu Pro Cys Cys Phe Leu Arg Ile Gln Asn Asp Ser 
385                 390                 395                 400 
Ile Ile Arg Leu Gly Asp Leu Gln Pro Leu Ser Gln Arg Val Ser Thr 
                405                 410                 415     
Asp Trp Gln Trp Pro Trp Asn Trp Asp Leu Gly Leu Thr Ala Trp Val 
            420                 425                 430         
Arg Glu Thr Ile His Ser Val Leu Ser Leu Phe Leu Leu Ala Leu Phe 
        435                 440                 445             
Leu Leu Phe Leu Ala Pro Cys Leu Ile Lys Cys Leu Thr Ser Arg Leu 
    450                 455                 460                 
Leu Lys Leu Leu Arg Gln Ala Pro His Phe Pro Glu Ile Ser Leu Ala 
465                 470                 475                 480 
Pro Lys Pro Asp Ser Asp Tyr Gln Ala Leu Leu Pro Ser Ala Pro Glu 
                485                 490                 495     
Ile Tyr Ser His Leu Ser Pro Thr Lys Pro Asp Tyr Ile Asn Leu Arg 
            500                 505                 510         
Pro Cys Pro 
        515 

<210> 40
<211> 515
<212> PRT
<213> Artificial Sequence


<220> 
<223> Amino acid sequence of BLV envelope

<400> 40
Met Pro Lys Glu Arg Arg Ser Arg Arg Arg Pro Gln Pro Ile Ile Arg 
1               5                   10                  15      
Trp Val Ser Leu Thr Leu Thr Leu Leu Ser Leu Cys Gln Pro Ile Gln 
            20                  25                  30          
Thr Trp Arg Cys Ser Leu Ser Leu Gly Asn Gln Gln Trp Met Thr Thr 
        35                  40                  45              
Tyr Asn Gln Glu Ala Lys Phe Ser Ile Ala Ile Asp Gln Ile Leu Glu 
    50                  55                  60                  
Ala His Asn Gln Ser Pro Phe Cys Pro Arg Ser Pro Arg Tyr Thr Leu 
65                  70                  75                  80  
Asp Phe Val Asn Gly Tyr Pro Lys Ile Tyr Trp Pro Pro Pro Gln Gly 
                85                  90                  95      
Arg Arg Arg Phe Gly Ala Arg Ala Met Val Thr Tyr Asp Cys Glu Pro 
            100                 105                 110         
Arg Cys Pro Tyr Val Gly Ala Asp His Phe Asp Cys Pro His Trp Asp 
        115                 120                 125             
Asn Ala Ser Gln Ala Asp Gln Gly Ser Phe Tyr Val Asn His Gln Ile 
    130                 135                 140                 
Leu Phe Leu His Leu Lys Gln Cys His Gly Ile Phe Thr Leu Thr Trp 
145                 150                 155                 160 
Glu Ile Trp Gly Tyr Asp Pro Leu Ile Thr Phe Ser Leu His Lys Ile 
                165                 170                 175     
Pro Ala Pro Pro Gln Pro Asp Phe Pro Gln Leu Asn Ser Asp Trp Val 
            180                 185                 190         
Pro Ser Val Arg Ser Trp Ala Leu Leu Leu Asn Gln Thr Ala Arg Ala 
        195                 200                 205             
Phe Pro Asp Cys Ala Ile Cys Trp Glu Pro Ser Pro Pro Trp Ala Pro 
    210                 215                 220                 
Glu Ile Leu Val Tyr Asn Lys Thr Ile Ser Asn Ser Gly Pro Gly Leu 
225                 230                 235                 240 
Ala Leu Pro Asp Ala Gln Ile Phe Trp Val Asn Thr Ser Leu Phe Asn 
                245                 250                 255     
Thr Thr Gln Gly Trp His His Pro Ser Gln Arg Leu Leu Phe Asn Val 
            260                 265                 270         
Ser Gln Gly Asn Ala Leu Leu Leu Pro Pro Ile Ser Leu Val Asn Leu 
        275                 280                 285             
Ser Thr Ala Ser Ser Ala Pro Pro Thr Arg Val Arg Arg Ser Pro Ala 
    290                 295                 300                 
Ala Ala Leu Thr Leu Gly Leu Ala Leu Ser Val Gly Leu Thr Gly Ile 
305                 310                 315                 320 
Asn Val Ala Val Ser Ala Leu Ser His Gln Arg Leu Thr Ser Leu Ile 
                325                 330                 335     
His Val Leu Glu Gln Asp Gln Gln Arg Leu Ile Thr Ala Ile Asn Gln 
            340                 345                 350         
Thr His Tyr Asn Leu Leu Asn Val Ala Ser Val Val Ala Gln Asn Arg 
        355                 360                 365             
Arg Gly Leu Asp Trp Leu Tyr Ile Arg Leu Gly Phe Gln Ser Leu Cys 
    370                 375                 380                 
Pro Thr Ile Asn Glu Pro Cys Cys Phe Leu Arg Ile Gln Asn Asp Ser 
385                 390                 395                 400 
Ile Ile Arg Leu Gly Asp Leu Gln Pro Leu Ser Gln Arg Val Ser Thr 
                405                 410                 415     
Asp Trp Gln Trp Pro Trp Asn Trp Asp Leu Gly Leu Thr Ala Trp Val 
            420                 425                 430         
Arg Glu Thr Ile His Ser Val Leu Ser Leu Phe Leu Leu Ala Leu Phe 
        435                 440                 445             
Leu Leu Phe Leu Ala Pro Cys Leu Ile Lys Cys Leu Thr Ser Arg Leu 
    450                 455                 460                 
Leu Lys Leu Leu Arg Gln Ala Pro His Phe Pro Glu Ile Ser Leu Ala 
465                 470                 475                 480 
Pro Lys Pro Asp Ser Asp Tyr Gln Ala Leu Leu Pro Ser Ala Pro Glu 
                485                 490                 495     
Ile Tyr Ser His Leu Ser Pro Thr Lys Pro Asp Tyr Ile Asn Leu Arg 
            500                 505                 510         
Pro Cys Pro 
        515 

<210> 41
<211> 515
<212> PRT
<213> Artificial Sequence


<220> 
<223> Amino acid sequence of BLV envelope

<400> 41
Met Pro Lys Glu Arg Arg Ser Arg Arg Arg Pro Gln Pro Ile Ile Arg 
1               5                   10                  15      
Trp Ile Ser Leu Thr Leu Thr Leu Leu Ser Leu Cys Gln Pro Ile Gln 
            20                  25                  30          
Thr Trp Arg Cys Ser Leu Ser Leu Gly Asn Gln Gln Trp Met Thr Thr 
        35                  40                  45              
Tyr Asn Gln Glu Ala Lys Phe Ser Ile Ala Ile Asp Gln Ile Leu Glu 
    50                  55                  60                  
Ala His Asn Gln Ser Pro Phe Cys Pro Arg Ser Pro Arg Tyr Thr Leu 
65                  70                  75                  80  
Asp Phe Val Asn Gly Tyr Pro Lys Ile Tyr Trp Pro Pro Pro Gln Gly 
                85                  90                  95      
Arg Arg Arg Phe Gly Ala Arg Ala Met Val Thr Tyr Asp Cys Glu Pro 
            100                 105                 110         
Arg Cys Pro Tyr Val Gly Ala Asp His Phe Asp Cys Pro His Trp Asp 
        115                 120                 125             
Asn Ala Ser Gln Ala Asp Gln Gly Ser Phe Tyr Val Asn His Gln Ile 
    130                 135                 140                 
Leu Phe Leu His Leu Lys Gln Cys His Gly Ile Phe Thr Leu Thr Trp 
145                 150                 155                 160 
Glu Ile Trp Gly Tyr Asp Pro Leu Ile Thr Phe Ser Leu His Lys Ile 
                165                 170                 175     
Pro Asp Pro Pro Gln Pro Asp Phe Pro Gln Leu Asn Ser Asp Trp Val 
            180                 185                 190         
Pro Ser Val Arg Ser Trp Ala Leu Leu Leu Asn Gln Thr Ala Arg Ala 
        195                 200                 205             
Phe Pro Asp Cys Ala Ile Cys Trp Glu Pro Ser Pro Pro Trp Ala Pro 
    210                 215                 220                 
Glu Ile Leu Val Tyr Asn Lys Thr Ile Ser Asn Ser Gly Pro Gly Leu 
225                 230                 235                 240 
Ala Leu Pro Asp Ala Gln Ile Phe Trp Val Asn Thr Ser Leu Phe Asn 
                245                 250                 255     
Thr Thr Gln Gly Trp His His Pro Ser Gln Arg Leu Leu Phe Asn Val 
            260                 265                 270         
Ser Gln Gly Asn Ala Leu Leu Leu Pro Pro Ile Ser Leu Val Asn Leu 
        275                 280                 285             
Ser Thr Ala Ser Ser Ala Pro Pro Thr Arg Val Arg Arg Ser Pro Ala 
    290                 295                 300                 
Ala Ala Leu Thr Leu Gly Leu Ala Leu Ser Val Gly Leu Thr Gly Ile 
305                 310                 315                 320 
Asn Val Ala Val Ser Ala Leu Ser His Gln Arg Leu Thr Ser Leu Ile 
                325                 330                 335     
His Val Leu Glu Gln Asp Gln Gln Arg Leu Ile Thr Ala Ile Asn Gln 
            340                 345                 350         
Thr His Tyr Asn Leu Leu Asn Val Ala Ser Val Val Ala Gln Asn Arg 
        355                 360                 365             
Arg Gly Leu Asp Trp Leu Tyr Ile Arg Leu Gly Phe Gln Ser Leu Cys 
    370                 375                 380                 
Pro Thr Ile Asn Glu Pro Cys Cys Phe Leu Arg Ile Gln Asn Asp Ser 
385                 390                 395                 400 
Ile Ile Arg Leu Gly Asp Leu Gln Pro Leu Ser Gln Arg Val Ser Thr 
                405                 410                 415     
Asp Trp Gln Trp Pro Trp Asn Trp Asp Leu Gly Leu Thr Ala Trp Val 
            420                 425                 430         
Arg Glu Thr Ile His Ser Val Leu Ser Leu Phe Leu Leu Ala Leu Phe 
        435                 440                 445             
Leu Leu Phe Leu Ala Pro Cys Leu Ile Lys Cys Leu Thr Ser Arg Leu 
    450                 455                 460                 
Leu Lys Leu Leu Arg Gln Ala Pro His Phe Pro Glu Ile Ser Leu Ala 
465                 470                 475                 480 
Pro Lys Pro Asp Ser Asp Tyr Gln Ala Leu Leu Pro Ser Ala Pro Glu 
                485                 490                 495     
Ile Tyr Ser His Leu Ser Pro Thr Lys Pro Asp Tyr Ile Asn Leu Arg 
            500                 505                 510         
Pro Cys Pro 
        515 

<210> 42
<211> 515
<212> PRT
<213> Artificial Sequence


<220> 
<223> Amino acid sequence of BLV envelope

<400> 42
Met Pro Lys Glu Arg Arg Ser Arg Arg Arg Pro Gln Pro Ile Ile Arg 
1               5                   10                  15      
Trp Ile Ser Leu Thr Leu Thr Leu Leu Ala Leu Cys Arg Pro Ile Gln 
            20                  25                  30          
Thr Trp Arg Cys Ser Leu Ser Leu Gly Asn Gln Gln Trp Met Thr Ala 
        35                  40                  45              
Tyr Asn Gln Glu Ala Lys Phe Ser Ile Ser Ile Asp Gln Ile Leu Glu 
    50                  55                  60                  
Ala His Asn Gln Ser Pro Phe Cys Ala Lys Ser Pro Arg Tyr Thr Leu 
65                  70                  75                  80  
Asp Ser Val Asn Gly Tyr Pro Lys Ile Tyr Trp Pro Pro Pro Lys Gly 
                85                  90                  95      
Arg Arg Arg Phe Gly Ala Arg Ala Met Val Thr Tyr Asp Cys Glu Pro 
            100                 105                 110         
Arg Cys Pro Tyr Val Gly Ala Asp Arg Phe Asp Cys Pro His Trp Asp 
        115                 120                 125             
Asn Ala Ser Gln Ala Asp Gln Gly Ser Phe Tyr Val Asn His Gln Ile 
    130                 135                 140                 
Leu Phe Leu His Leu Lys Gln Cys His Gly Ile Phe Thr Leu Thr Trp 
145                 150                 155                 160 
Glu Ile Trp Gly Tyr Asp Pro Leu Ile Thr Phe Ser Leu His Lys Ile 
                165                 170                 175     
Pro Ala Pro Pro Gln Pro Asp Phe Pro Gln Leu Asn Ser Asp Trp Val 
            180                 185                 190         
Pro Ser Val Arg Ser Trp Ala Leu Leu Leu Asn Gln Thr Ala Arg Ala 
        195                 200                 205             
Phe Pro Asp Cys Ala Ile Cys Trp Glu Pro Ser Pro Pro Trp Ala Pro 
    210                 215                 220                 
Glu Ile Leu Val Tyr Asn Lys Thr Ile Ser Ser Ser Gly Pro Gly Leu 
225                 230                 235                 240 
Ala Leu Pro Asp Ala Gln Ile Phe Trp Val Asn Thr Ser Ser Phe Asn 
                245                 250                 255     
Thr Thr Gln Gly Trp His His Pro Ser Gln Arg Leu Leu Phe Asn Val 
            260                 265                 270         
Ser Gln Gly Asn Ala Leu Leu Leu Pro Pro Ile Ser Leu Val Asn Leu 
        275                 280                 285             
Ser Thr Ala Ser Ser Ala Pro Pro Thr Arg Val Arg Arg Ser Pro Val 
    290                 295                 300                 
Ala Ala Leu Thr Leu Gly Leu Ala Leu Ser Val Gly Leu Thr Gly Ile 
305                 310                 315                 320 
Asn Val Ala Val Ser Ala Leu Ser His Gln Arg Leu Thr Ser Leu Ile 
                325                 330                 335     
His Val Leu Glu Gln Asp Gln Gln Arg Leu Ile Thr Ala Ile Asn Gln 
            340                 345                 350         
Thr His Tyr Asn Leu Leu Asn Val Ala Ser Val Val Ala Gln Asn Arg 
        355                 360                 365             
Arg Gly Leu Asp Trp Leu Tyr Ile Arg Leu Gly Phe Gln Ser Leu Cys 
    370                 375                 380                 
Pro Thr Ile Asn Glu Pro Cys Cys Phe Leu Arg Ile Gln Asn Asp Ser 
385                 390                 395                 400 
Ile Ile Arg Leu Gly Asp Leu Gln Pro Leu Ser Gln Arg Val Ser Thr 
                405                 410                 415     
Asp Trp Gln Trp Pro Trp Asn Trp Asp Leu Gly Leu Thr Ala Trp Val 
            420                 425                 430         
Arg Glu Thr Ile His Ser Val Leu Ser Leu Phe Leu Leu Ala Leu Phe 
        435                 440                 445             
Leu Leu Phe Leu Ala Pro Cys Leu Ile Lys Cys Leu Thr Ser Arg Leu 
    450                 455                 460                 
Leu Lys Leu Leu Arg Gln Ala Pro His Phe Pro Glu Ile Ser Leu Thr 
465                 470                 475                 480 
Pro Lys Pro Asp Ser Asp Tyr Gln Ala Leu Leu Pro Ser Ala Pro Glu 
                485                 490                 495     
Ile Tyr Ser His Leu Ser Pro Val Lys Pro Asp Tyr Ile Asn Leu Arg 
            500                 505                 510         
Pro Cys Pro 
        515 

<210> 43
<211> 515
<212> PRT
<213> Artificial Sequence


<220> 
<223> Amino acid sequence of BLV envelope

<400> 43
Met Pro Lys Glu Arg Arg Ser Arg Arg Arg Pro Gln Pro Ile Ile Arg 
1               5                   10                  15      
Trp Val Ser Leu Thr Leu Thr Leu Leu Ala Leu Cys Arg Pro Ile Gln 
            20                  25                  30          
Thr Trp Arg Cys Ser Leu Ser Leu Gly Asn Gln Gln Trp Met Thr Ala 
        35                  40                  45              
Tyr Asn Gln Glu Ala Lys Phe Ser Ile Ser Ile Asp Gln Ile Leu Glu 
    50                  55                  60                  
Ala His Asn Gln Ser Pro Phe Cys Ala Lys Ser Pro Arg Tyr Thr Leu 
65                  70                  75                  80  
Asp Ser Val Asn Gly Tyr Pro Lys Ile Tyr Trp Pro Pro Pro Lys Gly 
                85                  90                  95      
Arg Arg Arg Phe Gly Ala Arg Ala Met Val Thr Tyr Asp Cys Glu Pro 
            100                 105                 110         
Arg Cys Pro Tyr Val Gly Ala Asp Arg Phe Asp Cys Pro His Trp Asp 
        115                 120                 125             
Asn Ala Ser Gln Ala Asp Gln Gly Ser Phe Tyr Val Asn His Gln Ile 
    130                 135                 140                 
Leu Phe Leu His Leu Lys Gln Cys His Gly Ile Phe Thr Leu Thr Trp 
145                 150                 155                 160 
Glu Ile Trp Gly Tyr Asp Pro Leu Ile Thr Phe Ser Leu His Lys Ile 
                165                 170                 175     
Pro Ala Pro Pro Gln Pro Asp Phe Pro Gln Leu Asn Ser Asp Trp Val 
            180                 185                 190         
Pro Ser Val Arg Ser Trp Ala Leu Leu Leu Asn Gln Thr Ala Arg Ala 
        195                 200                 205             
Phe Pro Asp Cys Ala Ile Cys Trp Glu Pro Ser Pro Pro Trp Ala Pro 
    210                 215                 220                 
Glu Ile Leu Val Tyr Asn Lys Thr Ile Ser Ser Ser Gly Pro Gly Leu 
225                 230                 235                 240 
Ala Leu Pro Asp Ala Gln Ile Phe Trp Val Asn Thr Ser Ser Phe Asn 
                245                 250                 255     
Thr Thr Gln Gly Trp His His Pro Ser Gln Arg Leu Leu Phe Asn Val 
            260                 265                 270         
Ser Gln Gly Asn Ala Leu Leu Leu Pro Pro Ile Ser Leu Val Asn Leu 
        275                 280                 285             
Ser Thr Ala Ser Ser Ala Pro Pro Thr Arg Val Arg Arg Ser Pro Val 
    290                 295                 300                 
Ala Ala Leu Thr Leu Gly Leu Ala Leu Ser Val Gly Leu Thr Gly Ile 
305                 310                 315                 320 
Asn Val Ala Val Ser Ala Leu Ser His Gln Arg Leu Thr Ser Leu Ile 
                325                 330                 335     
His Val Leu Glu Gln Asp Gln Gln Arg Leu Ile Thr Ala Ile Asn Gln 
            340                 345                 350         
Thr His Tyr Asn Leu Leu Asn Val Ala Ser Val Val Ala Gln Asn Arg 
        355                 360                 365             
Arg Gly Leu Asp Trp Leu Tyr Ile Arg Leu Gly Phe Gln Ser Leu Cys 
    370                 375                 380                 
Pro Thr Ile Asn Glu Pro Cys Cys Phe Leu Arg Ile Gln Asn Asp Ser 
385                 390                 395                 400 
Ile Ile Arg Leu Gly Asp Leu Gln Pro Leu Ser Gln Arg Val Ser Thr 
                405                 410                 415     
Asp Trp Gln Trp Pro Trp Asn Trp Asp Leu Gly Leu Thr Ala Trp Val 
            420                 425                 430         
Arg Glu Thr Ile His Ser Val Leu Ser Leu Phe Leu Leu Ala Leu Phe 
        435                 440                 445             
Leu Leu Phe Leu Ala Pro Cys Leu Ile Lys Cys Leu Thr Ser Arg Leu 
    450                 455                 460                 
Leu Lys Leu Leu Arg Gln Ala Pro His Phe Pro Glu Ile Ser Leu Thr 
465                 470                 475                 480 
Pro Lys Pro Asp Ser Asp Tyr Gln Ala Leu Leu Pro Ser Ala Pro Glu 
                485                 490                 495     
Ile Tyr Ser His Leu Ser Pro Val Lys Pro Asp Tyr Ile Asn Leu Arg 
            500                 505                 510         
Pro Cys Pro 
        515 

<210> 44
<211> 515
<212> PRT
<213> Artificial Sequence


<220> 
<223> Amino acid sequence of BLV envelope

<400> 44
Met Pro Lys Glu Arg Arg Ser Arg Arg Arg Pro Gln Pro Ile Ile Arg 
1               5                   10                  15      
Trp Ile Ser Leu Thr Leu Thr Leu Leu Ala Leu Cys Arg Pro Ile Gln 
            20                  25                  30          
Thr Trp Arg Cys Ser Leu Ser Leu Gly Asn Gln Gln Trp Met Thr Ala 
        35                  40                  45              
Tyr Asn Gln Glu Ala Lys Phe Ser Ile Ser Ile Asp Gln Ile Leu Glu 
    50                  55                  60                  
Ala His Asn Gln Ser Pro Phe Cys Ala Lys Ser Pro Arg Tyr Thr Leu 
65                  70                  75                  80  
Asp Ser Val Asn Gly Tyr Pro Lys Ile Tyr Trp Pro Pro Pro Lys Gly 
                85                  90                  95      
Arg Arg Arg Phe Gly Ala Arg Ala Met Val Thr Tyr Asp Cys Glu Pro 
            100                 105                 110         
Arg Cys Pro Tyr Val Gly Ala Asp Arg Phe Asp Cys Pro His Trp Asp 
        115                 120                 125             
Asn Ala Ser Gln Ala Asp Gln Gly Ser Phe Tyr Val Asn His Gln Ile 
    130                 135                 140                 
Leu Phe Leu His Leu Lys Gln Cys His Gly Ile Phe Thr Leu Thr Trp 
145                 150                 155                 160 
Glu Ile Trp Gly Tyr Asp Pro Leu Ile Thr Phe Ser Leu His Lys Ile 
                165                 170                 175     
Pro Asp Pro Pro Gln Pro Asp Phe Pro Gln Leu Asn Ser Asp Trp Val 
            180                 185                 190         
Pro Ser Val Arg Ser Trp Ala Leu Leu Leu Asn Gln Thr Ala Arg Ala 
        195                 200                 205             
Phe Pro Asp Cys Ala Ile Cys Trp Glu Pro Ser Pro Pro Trp Ala Pro 
    210                 215                 220                 
Glu Ile Leu Val Tyr Asn Lys Thr Ile Ser Ser Ser Gly Pro Gly Leu 
225                 230                 235                 240 
Ala Leu Pro Asp Ala Gln Ile Phe Trp Val Asn Thr Ser Ser Phe Asn 
                245                 250                 255     
Thr Thr Gln Gly Trp His His Pro Ser Gln Arg Leu Leu Phe Asn Val 
            260                 265                 270         
Ser Gln Gly Asn Ala Leu Leu Leu Pro Pro Ile Ser Leu Val Asn Leu 
        275                 280                 285             
Ser Thr Ala Ser Ser Ala Pro Pro Thr Arg Val Arg Arg Ser Pro Val 
    290                 295                 300                 
Ala Ala Leu Thr Leu Gly Leu Ala Leu Ser Val Gly Leu Thr Gly Ile 
305                 310                 315                 320 
Asn Val Ala Val Ser Ala Leu Ser His Gln Arg Leu Thr Ser Leu Ile 
                325                 330                 335     
His Val Leu Glu Gln Asp Gln Gln Arg Leu Ile Thr Ala Ile Asn Gln 
            340                 345                 350         
Thr His Tyr Asn Leu Leu Asn Val Ala Ser Val Val Ala Gln Asn Arg 
        355                 360                 365             
Arg Gly Leu Asp Trp Leu Tyr Ile Arg Leu Gly Phe Gln Ser Leu Cys 
    370                 375                 380                 
Pro Thr Ile Asn Glu Pro Cys Cys Phe Leu Arg Ile Gln Asn Asp Ser 
385                 390                 395                 400 
Ile Ile Arg Leu Gly Asp Leu Gln Pro Leu Ser Gln Arg Val Ser Thr 
                405                 410                 415     
Asp Trp Gln Trp Pro Trp Asn Trp Asp Leu Gly Leu Thr Ala Trp Val 
            420                 425                 430         
Arg Glu Thr Ile His Ser Val Leu Ser Leu Phe Leu Leu Ala Leu Phe 
        435                 440                 445             
Leu Leu Phe Leu Ala Pro Cys Leu Ile Lys Cys Leu Thr Ser Arg Leu 
    450                 455                 460                 
Leu Lys Leu Leu Arg Gln Ala Pro His Phe Pro Glu Ile Ser Leu Thr 
465                 470                 475                 480 
Pro Lys Pro Asp Ser Asp Tyr Gln Ala Leu Leu Pro Ser Ala Pro Glu 
                485                 490                 495     
Ile Tyr Ser His Leu Ser Pro Val Lys Pro Asp Tyr Ile Asn Leu Arg 
            500                 505                 510         
Pro Cys Pro 
        515 

<210> 45
<211> 515
<212> PRT
<213> Artificial Sequence


<220> 
<223> Amino acid sequence of BLV envelope

<400> 45
Met Pro Lys Glu Arg Arg Ser Arg Arg Arg Pro Gln Pro Ile Ile Arg 
1               5                   10                  15      
Trp Ile Ser Leu Thr Leu Thr Leu Leu Ala Leu Cys Gln Pro Ile Gln 
            20                  25                  30          
Thr Trp Arg Cys Ser Leu Ser Leu Gly Asn Gln Gln Trp Met Thr Thr 
        35                  40                  45              
Tyr Asn Gln Glu Ala Lys Phe Phe Ile Ser Ile Asp Gln Ile Leu Glu 
    50                  55                  60                  
Ala His Asn Gln Ser Pro Phe Cys Pro Arg Ser Pro Arg Tyr Thr Leu 
65                  70                  75                  80  
Asp Phe Val Asn Gly Tyr Pro Lys Ile Tyr Trp Pro Pro Pro Gln Gly 
                85                  90                  95      
Arg Arg Arg Phe Gly Ala Arg Ala Met Val Thr Tyr Asp Cys Glu Pro 
            100                 105                 110         
Arg Cys Pro Tyr Val Gly Ala Asp His Phe Asp Cys Pro His Trp Asp 
        115                 120                 125             
Asn Ala Ser Gln Ala Asp Gln Gly Ser Phe Tyr Val Asn His Gln Thr 
    130                 135                 140                 
Leu Phe Leu His Leu Lys Gln Cys His Gly Ile Phe Thr Leu Thr Trp 
145                 150                 155                 160 
Glu Ile Trp Gly Tyr Asp Pro Leu Ile Thr Phe Ser Leu His Lys Ile 
                165                 170                 175     
Pro Asp Pro Pro Gln Pro Asp Phe Pro Gln Leu Asn Ser Asp Trp Val 
            180                 185                 190         
Pro Ser Val Arg Ser Trp Ala Leu Leu Leu Asn Gln Thr Ala Arg Ala 
        195                 200                 205             
Phe Pro Asn Cys Ala Ile Cys Trp Glu Pro Ser Pro Pro Trp Ala Pro 
    210                 215                 220                 
Glu Ile Leu Val Tyr Asn Lys Thr Ile Ser Ser Ser Gly Pro Gly Leu 
225                 230                 235                 240 
Ala Leu Pro Asp Ala Gln Ile Phe Trp Val Asn Thr Ser Leu Phe Asn 
                245                 250                 255     
Thr Thr Gln Gly Trp His His Pro Ser Gln Arg Leu Leu Phe Asn Val 
            260                 265                 270         
Ser Gln Gly Asn Ala Leu Leu Leu Pro Pro Ile Ser Leu Val Asn Leu 
        275                 280                 285             
Ser Thr Ala Ser Ser Ala Pro Pro Thr Arg Val Arg Arg Ser Pro Val 
    290                 295                 300                 
Ala Ala Leu Thr Leu Gly Leu Ala Leu Ser Val Gly Leu Thr Gly Ile 
305                 310                 315                 320 
Asn Val Ala Val Ser Ala Leu Ser His Gln Arg Leu Thr Ser Leu Ile 
                325                 330                 335     
His Val Leu Glu Gln Asp Gln Gln Arg Leu Ile Thr Ala Ile Asn Gln 
            340                 345                 350         
Thr His Tyr Asn Leu Leu Asn Val Ala Ser Val Val Ala Gln Asn Arg 
        355                 360                 365             
Arg Gly Leu Asp Trp Leu Tyr Ile Arg Leu Gly Phe Gln Ser Leu Cys 
    370                 375                 380                 
Pro Thr Ile Asn Glu Pro Cys Cys Phe Leu Arg Ile Gln Asn Asp Ser 
385                 390                 395                 400 
Ile Ile Arg Leu Gly Asp Leu Gln Pro Leu Ser Gln Arg Val Ser Thr 
                405                 410                 415     
Asp Trp Gln Trp Pro Trp Asn Trp Asp Leu Gly Leu Thr Ala Trp Val 
            420                 425                 430         
Arg Glu Leu Ile His Ser Val Leu Ser Leu Phe Leu Leu Ala Leu Phe 
        435                 440                 445             
Leu Leu Phe Leu Ala Pro Cys Leu Ile Lys Cys Leu Thr Ser Arg Leu 
    450                 455                 460                 
Leu Lys Leu Leu Arg Gln Ala Pro His Phe Pro Glu Ile Ser Phe Pro 
465                 470                 475                 480 
Pro Lys Pro Asp Ser Asp Tyr Gln Ala Leu Leu Pro Ser Ala Pro Glu 
                485                 490                 495     
Ile Tyr Ser His Leu Ser Pro Thr Lys Pro Asp Tyr Ile Asn Leu Arg 
            500                 505                 510         
Pro Cys Pro 
        515 

<210> 46
<211> 1548
<212> DNA
<213> Artificial Sequence


<220> 
<223> Nucleic acid sequence of BLV envelope

<400> 46
atgcccaaag aacgacggtc ccgaagacgc ccacaaccga tcatcagatg gatctccctc      60

actcttactc tcctcgctct ctgtcagccc atccagactt ggagatgctc cctgtcccta     120

ggaaatcaac aatggatgac aacatataac caagaggcaa aatttttcat ctccattgac     180

caaatactag aggctcataa tcaatcacct ttctgtccca ggtctcccag atacaccttg     240

gactttgtaa atggttatcc taagatctat tggccccccc cacaagggcg gcgccggttt     300

ggagccaggg ccatggtcac atatgattgc gagccccgat gcccttatgt gggggcagat     360

cacttcgact gcccccactg ggacaatgcc tcccaggccg atcaaggatc cttttatgtc     420

aatcatcaga ctttattcct gcatctcaaa caatgtcatg gaattttcac tctaacctgg     480

gaaatatggg gatatgatcc cctgatcacc ttttctttac ataaaatccc tgatccccct     540

caacccgact tccctcagct gaacagtgac tgggttccct ctgtcagatc atgggccctg     600

cttttaaatc aaacggcacg ggccttccca aactgtgcta tatgttggga accctcccct     660

ccctgggctc ccgaaatatt agtatataac aaaaccatct ccagctctgg acccggtctc     720

gccctcccgg acgcccaaat cttctgggtc aacacgtcct tgtttaacac cacccaagga     780

tggcaccacc cttcccagag gttgttgttc aacgtttctc aaggcaacgc cttattattg     840

ccccctatct ccctggttaa tctctctacg gcttcctccg cccctcctac ccgggtcaga     900

cgcagtcccg tcgcagccct gaccttaggc ctagccctgt cagtggggct cactggaatt     960

aatgtagccg tgtctgccct tagccatcag agactcacct ccctgatcca cgttctggag    1020

caagatcagc aacgcttgat cacagcaatt aaccagaccc actataattt gcttaatgtg    1080

gcctctgtgg tcgcccagaa ccgacggggg cttgattggt tgtacatccg gctgggtttt    1140

caaagtctat gtcccacaat caatgaacct tgctgtttcc tgcgcatcca aaatgactcc    1200

attatccgcc tcggtgatct ccagcctctc tcgcaaagag tctctacaga ctggcagtgg    1260

ccctggaatt gggatctggg gctcaccgcc tgggtgcggg agctcattca ttctgttcta    1320

agcctattcc tattagccct ttttttgctc ttcttggccc cctgcctgat aaaatgcttg    1380

acctctcgcc ttttaaaact cctccggcag gctccccact tccctgaaat ctccttcccc    1440

cctaaacccg attctgatta tcaggccttg ctaccatccg cgccagagat ctactctcac    1500

ctctccccca ccaaacccga ttacatcaac cttcgaccct gcccctag                 1548


<210> 47
<211> 515
<212> PRT
<213> Artificial Sequence


<220> 
<223> Amino acid sequence of BLV envelope

<400> 47
Met Pro Lys Glu Arg Arg Ser Arg Arg Arg Pro Gln Pro Ile Ile Arg 
1               5                   10                  15      
Trp Ile Ser Leu Thr Leu Thr Leu Leu Ala Leu Cys Gln Pro Ile Gln 
            20                  25                  30          
Thr Trp Arg Cys Ser Leu Ser Leu Gly Asn Gln Gln Trp Met Thr Thr 
        35                  40                  45              
Tyr Asn Gln Glu Ala Lys Phe Phe Ile Ser Ile Asp Gln Ile Leu Glu 
    50                  55                  60                  
Ala His Asn Gln Ser Pro Phe Cys Pro Arg Ser Pro Arg Tyr Thr Leu 
65                  70                  75                  80  
Asp Phe Val Asn Gly Tyr Pro Lys Ile Tyr Trp Pro Pro Pro Gln Gly 
                85                  90                  95      
Arg Arg Arg Phe Gly Ala Arg Ala Met Val Thr Tyr Asp Cys Glu Pro 
            100                 105                 110         
Arg Cys Pro Tyr Val Gly Ala Asp His Phe Asp Cys Pro His Trp Asp 
        115                 120                 125             
Asn Ala Ser Gln Ala Asp Gln Gly Ser Phe Tyr Val Asn His Gln Thr 
    130                 135                 140                 
Leu Phe Leu His Leu Lys Gln Cys His Gly Ile Phe Thr Leu Thr Trp 
145                 150                 155                 160 
Glu Ile Trp Gly Tyr Asp Pro Leu Ile Thr Phe Ser Leu His Lys Ile 
                165                 170                 175     
Pro Ala Pro Pro Gln Pro Asp Phe Pro Gln Leu Asn Ser Asp Trp Val 
            180                 185                 190         
Pro Ser Val Arg Ser Trp Ala Leu Leu Leu Asn Gln Thr Ala Arg Ala 
        195                 200                 205             
Phe Pro Asn Cys Ala Ile Cys Trp Glu Pro Ser Pro Pro Trp Ala Pro 
    210                 215                 220                 
Glu Ile Leu Val Tyr Asn Lys Thr Ile Ser Ser Ser Gly Pro Gly Leu 
225                 230                 235                 240 
Ala Leu Pro Asp Ala Gln Ile Phe Trp Val Asn Thr Ser Leu Phe Asn 
                245                 250                 255     
Thr Thr Gln Gly Trp His His Pro Ser Gln Arg Leu Leu Phe Asn Val 
            260                 265                 270         
Ser Gln Gly Asn Ala Leu Leu Leu Pro Pro Ile Ser Leu Val Asn Leu 
        275                 280                 285             
Ser Thr Ala Ser Ser Ala Pro Pro Thr Arg Val Arg Arg Ser Pro Val 
    290                 295                 300                 
Ala Ala Leu Thr Leu Gly Leu Ala Leu Ser Val Gly Leu Thr Gly Ile 
305                 310                 315                 320 
Asn Val Ala Val Ser Ala Leu Ser His Gln Arg Leu Thr Ser Leu Ile 
                325                 330                 335     
His Val Leu Glu Gln Asp Gln Gln Arg Leu Ile Thr Ala Ile Asn Gln 
            340                 345                 350         
Thr His Tyr Asn Leu Leu Asn Val Ala Ser Val Val Ala Gln Asn Arg 
        355                 360                 365             
Arg Gly Leu Asp Trp Leu Tyr Ile Arg Leu Gly Phe Gln Ser Leu Cys 
    370                 375                 380                 
Pro Thr Ile Asn Glu Pro Cys Cys Phe Leu Arg Ile Gln Asn Asp Ser 
385                 390                 395                 400 
Ile Ile Arg Leu Gly Asp Leu Gln Pro Leu Ser Gln Arg Val Ser Thr 
                405                 410                 415     
Asp Trp Gln Trp Pro Trp Asn Trp Asp Leu Gly Leu Thr Ala Trp Val 
            420                 425                 430         
Arg Glu Leu Ile His Ser Val Leu Ser Leu Phe Leu Leu Ala Leu Phe 
        435                 440                 445             
Leu Leu Phe Leu Ala Pro Cys Leu Ile Lys Cys Leu Thr Ser Arg Leu 
    450                 455                 460                 
Leu Lys Leu Leu Arg Gln Ala Pro His Phe Pro Glu Ile Ser Phe Pro 
465                 470                 475                 480 
Pro Lys Pro Asp Ser Asp Tyr Gln Ala Leu Leu Pro Ser Ala Pro Glu 
                485                 490                 495     
Ile Tyr Ser His Leu Ser Pro Thr Lys Pro Asp Tyr Ile Asn Leu Arg 
            500                 505                 510         
Pro Cys Pro 
        515 

<210> 48
<211> 515
<212> PRT
<213> Artificial Sequence


<220> 
<223> Amino acid sequence of BLV envelope

<400> 48
Met Pro Lys Glu Arg Arg Ser Arg Arg Arg Pro Gln Pro Ile Ile Arg 
1               5                   10                  15      
Trp Val Ser Leu Thr Leu Thr Leu Leu Ala Leu Cys Gln Pro Ile Gln 
            20                  25                  30          
Thr Trp Arg Cys Ser Leu Ser Leu Gly Asn Gln Gln Trp Met Thr Thr 
        35                  40                  45              
Tyr Asn Gln Glu Ala Lys Phe Phe Ile Ser Ile Asp Gln Ile Leu Glu 
    50                  55                  60                  
Ala His Asn Gln Ser Pro Phe Cys Pro Arg Ser Pro Arg Tyr Thr Leu 
65                  70                  75                  80  
Asp Phe Val Asn Gly Tyr Pro Lys Ile Tyr Trp Pro Pro Pro Gln Gly 
                85                  90                  95      
Arg Arg Arg Phe Gly Ala Arg Ala Met Val Thr Tyr Asp Cys Glu Pro 
            100                 105                 110         
Arg Cys Pro Tyr Val Gly Ala Asp His Phe Asp Cys Pro His Trp Asp 
        115                 120                 125             
Asn Ala Ser Gln Ala Asp Gln Gly Ser Phe Tyr Val Asn His Gln Thr 
    130                 135                 140                 
Leu Phe Leu His Leu Lys Gln Cys His Gly Ile Phe Thr Leu Thr Trp 
145                 150                 155                 160 
Glu Ile Trp Gly Tyr Asp Pro Leu Ile Thr Phe Ser Leu His Lys Ile 
                165                 170                 175     
Pro Ala Pro Pro Gln Pro Asp Phe Pro Gln Leu Asn Ser Asp Trp Val 
            180                 185                 190         
Pro Ser Val Arg Ser Trp Ala Leu Leu Leu Asn Gln Thr Ala Arg Ala 
        195                 200                 205             
Phe Pro Asn Cys Ala Ile Cys Trp Glu Pro Ser Pro Pro Trp Ala Pro 
    210                 215                 220                 
Glu Ile Leu Val Tyr Asn Lys Thr Ile Ser Ser Ser Gly Pro Gly Leu 
225                 230                 235                 240 
Ala Leu Pro Asp Ala Gln Ile Phe Trp Val Asn Thr Ser Leu Phe Asn 
                245                 250                 255     
Thr Thr Gln Gly Trp His His Pro Ser Gln Arg Leu Leu Phe Asn Val 
            260                 265                 270         
Ser Gln Gly Asn Ala Leu Leu Leu Pro Pro Ile Ser Leu Val Asn Leu 
        275                 280                 285             
Ser Thr Ala Ser Ser Ala Pro Pro Thr Arg Val Arg Arg Ser Pro Val 
    290                 295                 300                 
Ala Ala Leu Thr Leu Gly Leu Ala Leu Ser Val Gly Leu Thr Gly Ile 
305                 310                 315                 320 
Asn Val Ala Val Ser Ala Leu Ser His Gln Arg Leu Thr Ser Leu Ile 
                325                 330                 335     
His Val Leu Glu Gln Asp Gln Gln Arg Leu Ile Thr Ala Ile Asn Gln 
            340                 345                 350         
Thr His Tyr Asn Leu Leu Asn Val Ala Ser Val Val Ala Gln Asn Arg 
        355                 360                 365             
Arg Gly Leu Asp Trp Leu Tyr Ile Arg Leu Gly Phe Gln Ser Leu Cys 
    370                 375                 380                 
Pro Thr Ile Asn Glu Pro Cys Cys Phe Leu Arg Ile Gln Asn Asp Ser 
385                 390                 395                 400 
Ile Ile Arg Leu Gly Asp Leu Gln Pro Leu Ser Gln Arg Val Ser Thr 
                405                 410                 415     
Asp Trp Gln Trp Pro Trp Asn Trp Asp Leu Gly Leu Thr Ala Trp Val 
            420                 425                 430         
Arg Glu Leu Ile His Ser Val Leu Ser Leu Phe Leu Leu Ala Leu Phe 
        435                 440                 445             
Leu Leu Phe Leu Ala Pro Cys Leu Ile Lys Cys Leu Thr Ser Arg Leu 
    450                 455                 460                 
Leu Lys Leu Leu Arg Gln Ala Pro His Phe Pro Glu Ile Ser Phe Pro 
465                 470                 475                 480 
Pro Lys Pro Asp Ser Asp Tyr Gln Ala Leu Leu Pro Ser Ala Pro Glu 
                485                 490                 495     
Ile Tyr Ser His Leu Ser Pro Thr Lys Pro Asp Tyr Ile Asn Leu Arg 
            500                 505                 510         
Pro Cys Pro 
        515 

<210> 49
<211> 515
<212> PRT
<213> Artificial Sequence


<220> 
<223> Amino acid sequence of BLV envelope

<400> 49
Met Pro Lys Glu Arg Arg Ser Arg Arg Arg Pro Gln Pro Ile Ile Arg 
1               5                   10                  15      
Trp Val Ser Leu Thr Leu Thr Leu Leu Ala Leu Cys Gln Pro Ile Gln 
            20                  25                  30          
Thr Trp Arg Cys Ser Leu Ser Leu Gly Asn Gln Gln Trp Met Thr Thr 
        35                  40                  45              
Tyr Asn Gln Glu Ala Lys Phe Phe Ile Ser Ile Asp Gln Ile Leu Glu 
    50                  55                  60                  
Ala His Asn Gln Ser Pro Phe Cys Pro Arg Ser Pro Arg Tyr Thr Leu 
65                  70                  75                  80  
Asp Phe Val Asn Gly Tyr Pro Lys Ile Tyr Trp Pro Pro Pro Gln Gly 
                85                  90                  95      
Arg Arg Arg Phe Gly Ala Arg Ala Met Val Thr Tyr Asp Cys Glu Pro 
            100                 105                 110         
Arg Cys Pro Tyr Val Gly Ala Asp His Phe Asp Cys Pro His Trp Asp 
        115                 120                 125             
Asn Ala Ser Gln Ala Asp Gln Gly Ser Phe Tyr Val Asn His Gln Thr 
    130                 135                 140                 
Leu Phe Leu His Leu Lys Gln Cys His Gly Ile Phe Thr Leu Thr Trp 
145                 150                 155                 160 
Glu Ile Trp Gly Tyr Asp Pro Leu Ile Thr Phe Ser Leu His Lys Ile 
                165                 170                 175     
Pro Asp Pro Pro Gln Pro Asp Phe Pro Gln Leu Asn Ser Asp Trp Val 
            180                 185                 190         
Pro Ser Val Arg Ser Trp Ala Leu Leu Leu Asn Gln Thr Ala Arg Ala 
        195                 200                 205             
Phe Pro Asn Cys Ala Ile Cys Trp Glu Pro Ser Pro Pro Trp Ala Pro 
    210                 215                 220                 
Glu Ile Leu Val Tyr Asn Lys Thr Ile Ser Ser Ser Gly Pro Gly Leu 
225                 230                 235                 240 
Ala Leu Pro Asp Ala Gln Ile Phe Trp Val Asn Thr Ser Leu Phe Asn 
                245                 250                 255     
Thr Thr Gln Gly Trp His His Pro Ser Gln Arg Leu Leu Phe Asn Val 
            260                 265                 270         
Ser Gln Gly Asn Ala Leu Leu Leu Pro Pro Ile Ser Leu Val Asn Leu 
        275                 280                 285             
Ser Thr Ala Ser Ser Ala Pro Pro Thr Arg Val Arg Arg Ser Pro Val 
    290                 295                 300                 
Ala Ala Leu Thr Leu Gly Leu Ala Leu Ser Val Gly Leu Thr Gly Ile 
305                 310                 315                 320 
Asn Val Ala Val Ser Ala Leu Ser His Gln Arg Leu Thr Ser Leu Ile 
                325                 330                 335     
His Val Leu Glu Gln Asp Gln Gln Arg Leu Ile Thr Ala Ile Asn Gln 
            340                 345                 350         
Thr His Tyr Asn Leu Leu Asn Val Ala Ser Val Val Ala Gln Asn Arg 
        355                 360                 365             
Arg Gly Leu Asp Trp Leu Tyr Ile Arg Leu Gly Phe Gln Ser Leu Cys 
    370                 375                 380                 
Pro Thr Ile Asn Glu Pro Cys Cys Phe Leu Arg Ile Gln Asn Asp Ser 
385                 390                 395                 400 
Ile Ile Arg Leu Gly Asp Leu Gln Pro Leu Ser Gln Arg Val Ser Thr 
                405                 410                 415     
Asp Trp Gln Trp Pro Trp Asn Trp Asp Leu Gly Leu Thr Ala Trp Val 
            420                 425                 430         
Arg Glu Leu Ile His Ser Val Leu Ser Leu Phe Leu Leu Ala Leu Phe 
        435                 440                 445             
Leu Leu Phe Leu Ala Pro Cys Leu Ile Lys Cys Leu Thr Ser Arg Leu 
    450                 455                 460                 
Leu Lys Leu Leu Arg Gln Ala Pro His Phe Pro Glu Ile Ser Phe Pro 
465                 470                 475                 480 
Pro Lys Pro Asp Ser Asp Tyr Gln Ala Leu Leu Pro Ser Ala Pro Glu 
                485                 490                 495     
Ile Tyr Ser His Leu Ser Pro Thr Lys Pro Asp Tyr Ile Asn Leu Arg 
            500                 505                 510         
Pro Cys Pro 
        515 

