                         SEQUENCE LISTING

<110>  University of Basel
 
<120>  Virulence attenuated bacteria for treatment of malignant solid 
       tumors

<130>  P5061PC00

<160>  224   

<170>  PatentIn version 3.5

<210>  1
<211>  219
<212>  PRT
<213>  Yersinia enterocolitica

<400>  1

Met Lys Ile Ser Ser Phe Ile Ser Thr Ser Leu Pro Leu Pro Ala Ser 
1               5                   10                  15      


Val Ser Gly Ser Ser Ser Val Gly Glu Met Ser Gly Arg Ser Val Ser 
            20                  25                  30          


Gln Gln Lys Ser Asp Gln Tyr Ala Asn Asn Leu Ala Gly Arg Thr Glu 
        35                  40                  45              


Ser Pro Gln Gly Ser Ser Leu Ala Ser Arg Ile Ile Glu Arg Leu Ser 
    50                  55                  60                  


Ser Met Ala His Ser Val Ile Gly Phe Ile Gln Arg Met Phe Ser Glu 
65                  70                  75                  80  


Gly Ser His Lys Pro Val Val Thr Pro Ala Leu Thr Pro Ala Gln Met 
                85                  90                  95      


Pro Ser Pro Thr Ser Phe Ser Asp Ser Ile Lys Gln Leu Ala Ala Glu 
            100                 105                 110         


Thr Leu Pro Lys Tyr Met Gln Gln Leu Ser Ser Leu Asp Ala Glu Thr 
        115                 120                 125             


Leu Gln Lys Asn His Asp Gln Phe Ala Thr Gly Ser Gly Pro Leu Arg 
    130                 135                 140                 


Gly Ser Ile Thr Gln Cys Gln Gly Leu Met Gln Phe Cys Gly Gly Glu 
145                 150                 155                 160 


Leu Gln Ala Glu Ala Ser Ala Ile Leu Asn Thr Pro Val Cys Gly Ile 
                165                 170                 175     


Pro Phe Ser Gln Trp Gly Thr Val Gly Gly Ala Ala Ser Ala Tyr Val 
            180                 185                 190         


Ala Ser Gly Val Asp Leu Thr Gln Ala Ala Asn Glu Ile Lys Gly Leu 
        195                 200                 205             


Gly Gln Gln Met Gln Gln Leu Leu Ser Leu Met 
    210                 215                 


<210>  2
<211>  138
<212>  PRT
<213>  Yersinia enterocolitica

<400>  2

Met Lys Ile Ser Ser Phe Ile Ser Thr Ser Leu Pro Leu Pro Ala Ser 
1               5                   10                  15      


Val Ser Gly Ser Ser Ser Val Gly Glu Met Ser Gly Arg Ser Val Ser 
            20                  25                  30          


Gln Gln Lys Ser Asp Gln Tyr Ala Asn Asn Leu Ala Gly Arg Thr Glu 
        35                  40                  45              


Ser Pro Gln Gly Ser Ser Leu Ala Ser Arg Ile Ile Glu Arg Leu Ser 
    50                  55                  60                  


Ser Met Ala His Ser Val Ile Gly Phe Ile Gln Arg Met Phe Ser Glu 
65                  70                  75                  80  


Gly Ser His Lys Pro Val Val Thr Pro Ala Leu Thr Pro Ala Gln Met 
                85                  90                  95      


Pro Ser Pro Thr Ser Phe Ser Asp Ser Ile Lys Gln Leu Ala Ala Glu 
            100                 105                 110         


Thr Leu Pro Lys Tyr Met Gln Gln Leu Ser Ser Leu Asp Ala Glu Thr 
        115                 120                 125             


Leu Gln Lys Asn His Asp Gln Phe Ala Thr 
    130                 135             


<210>  3
<211>  169
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YopE1-138-MycHis

<400>  3

Met Lys Ile Ser Ser Phe Ile Ser Thr Ser Leu Pro Leu Pro Ala Ser 
1               5                   10                  15      


Val Ser Gly Ser Ser Ser Val Gly Glu Met Ser Gly Arg Ser Val Ser 
            20                  25                  30          


Gln Gln Lys Ser Asp Gln Tyr Ala Asn Asn Leu Ala Gly Arg Thr Glu 
        35                  40                  45              


Ser Pro Gln Gly Ser Ser Leu Ala Ser Arg Ile Ile Glu Arg Leu Ser 
    50                  55                  60                  


Ser Met Ala His Ser Val Ile Gly Phe Ile Gln Arg Met Phe Ser Glu 
65                  70                  75                  80  


Gly Ser His Lys Pro Val Val Thr Pro Ala Leu Thr Pro Ala Gln Met 
                85                  90                  95      


Pro Ser Pro Thr Ser Phe Ser Asp Ser Ile Lys Gln Leu Ala Ala Glu 
            100                 105                 110         


Thr Leu Pro Lys Tyr Met Gln Gln Leu Ser Ser Leu Asp Ala Glu Thr 
        115                 120                 125             


Leu Gln Lys Asn His Asp Gln Phe Ala Thr Leu Glu Ser Arg Phe Glu 
    130                 135                 140                 


Lys Leu Gly Pro Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Asn Ser 
145                 150                 155                 160 


Ala Val Asp His His His His His His 
                165                 


<210>  4
<211>  348
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YopE1-138 - IpgB1

<400>  4

Met Lys Ile Ser Ser Phe Ile Ser Thr Ser Leu Pro Leu Pro Ala Ser 
1               5                   10                  15      


Val Ser Gly Ser Ser Ser Val Gly Glu Met Ser Gly Arg Ser Val Ser 
            20                  25                  30          


Gln Gln Lys Ser Asp Gln Tyr Ala Asn Asn Leu Ala Gly Arg Thr Glu 
        35                  40                  45              


Ser Pro Gln Gly Ser Ser Leu Ala Ser Arg Ile Ile Glu Arg Leu Ser 
    50                  55                  60                  


Ser Met Ala His Ser Val Ile Gly Phe Ile Gln Arg Met Phe Ser Glu 
65                  70                  75                  80  


Gly Ser His Lys Pro Val Val Thr Pro Ala Leu Thr Pro Ala Gln Met 
                85                  90                  95      


Pro Ser Pro Thr Ser Phe Ser Asp Ser Ile Lys Gln Leu Ala Ala Glu 
            100                 105                 110         


Thr Leu Pro Lys Tyr Met Gln Gln Leu Ser Ser Leu Asp Ala Glu Thr 
        115                 120                 125             


Leu Gln Lys Asn His Asp Gln Phe Ala Thr Leu Glu Met Gln Ile Leu 
    130                 135                 140                 


Asn Lys Ile Leu Pro Gln Val Glu Phe Ala Ile Pro Arg Pro Ser Phe 
145                 150                 155                 160 


Asp Ser Leu Ser Arg Asn Lys Leu Val Lys Lys Ile Leu Ser Val Phe 
                165                 170                 175     


Asn Leu Lys Gln Arg Phe Pro Gln Lys Asn Phe Gly Cys Pro Val Asn 
            180                 185                 190         


Ile Asn Lys Ile Arg Asp Ser Val Ile Asp Lys Ile Lys Asp Ser Asn 
        195                 200                 205             


Ser Gly Asn Gln Leu Phe Cys Trp Met Ser Gln Glu Arg Thr Thr Tyr 
    210                 215                 220                 


Val Ser Ser Met Ile Asn Arg Ser Ile Asp Glu Met Ala Ile His Asn 
225                 230                 235                 240 


Gly Val Val Leu Thr Ser Asp Asn Lys Arg Asn Ile Phe Ala Ala Ile 
                245                 250                 255     


Glu Lys Lys Phe Pro Asp Ile Lys Leu Asp Glu Lys Ser Ala Gln Thr 
            260                 265                 270         


Ser Ile Ser His Thr Ala Leu Asn Glu Ile Ala Ser Ser Gly Leu Arg 
        275                 280                 285             


Ala Lys Ile Leu Lys Arg Tyr Ser Ser Asp Met Asp Leu Phe Asn Thr 
    290                 295                 300                 


Gln Met Lys Asp Leu Thr Asn Leu Val Ser Ser Ser Val Tyr Asp Lys 
305                 310                 315                 320 


Ile Phe Asn Glu Ser Thr Lys Val Leu Gln Ile Glu Ile Ser Ala Glu 
                325                 330                 335     


Val Leu Lys Ala Val Tyr Arg Gln Ser Asn Thr Asn 
            340                 345             


<210>  5
<211>  380
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YopE1-138 - SopE

<400>  5

Met Lys Ile Ser Ser Phe Ile Ser Thr Ser Leu Pro Leu Pro Ala Ser 
1               5                   10                  15      


Val Ser Gly Ser Ser Ser Val Gly Glu Met Ser Gly Arg Ser Val Ser 
            20                  25                  30          


Gln Gln Lys Ser Asp Gln Tyr Ala Asn Asn Leu Ala Gly Arg Thr Glu 
        35                  40                  45              


Ser Pro Gln Gly Ser Ser Leu Ala Ser Arg Ile Ile Glu Arg Leu Ser 
    50                  55                  60                  


Ser Met Ala His Ser Val Ile Gly Phe Ile Gln Arg Met Phe Ser Glu 
65                  70                  75                  80  


Gly Ser His Lys Pro Val Val Thr Pro Ala Leu Thr Pro Ala Gln Met 
                85                  90                  95      


Pro Ser Pro Thr Ser Phe Ser Asp Ser Ile Lys Gln Leu Ala Ala Glu 
            100                 105                 110         


Thr Leu Pro Lys Tyr Met Gln Gln Leu Ser Ser Leu Asp Ala Glu Thr 
        115                 120                 125             


Leu Gln Lys Asn His Asp Gln Phe Ala Thr Leu Glu Val Thr Asn Ile 
    130                 135                 140                 


Thr Leu Ser Thr Gln His Tyr Arg Ile His Arg Ser Asp Val Glu Pro 
145                 150                 155                 160 


Val Lys Glu Lys Thr Thr Glu Lys Asp Ile Phe Ala Lys Ser Ile Thr 
                165                 170                 175     


Ala Val Arg Asn Ser Phe Ile Ser Leu Ser Thr Ser Leu Ser Asp Arg 
            180                 185                 190         


Phe Ser Leu His Gln Gln Thr Asp Ile Pro Thr Thr His Phe His Arg 
        195                 200                 205             


Gly Asn Ala Ser Glu Gly Arg Ala Val Leu Thr Ser Lys Thr Val Lys 
    210                 215                 220                 


Asp Phe Met Leu Gln Lys Leu Asn Ser Leu Asp Ile Lys Gly Asn Ala 
225                 230                 235                 240 


Ser Lys Asp Pro Ala Tyr Ala Arg Gln Thr Cys Glu Ala Ile Leu Ser 
                245                 250                 255     


Ala Val Tyr Ser Asn Asn Lys Asp Gln Cys Cys Lys Leu Leu Ile Ser 
            260                 265                 270         


Lys Gly Val Ser Ile Thr Pro Phe Leu Lys Glu Ile Gly Glu Ala Ala 
        275                 280                 285             


Gln Asn Ala Gly Leu Pro Gly Glu Ile Lys Asn Gly Val Phe Thr Pro 
    290                 295                 300                 


Gly Gly Ala Gly Ala Asn Pro Phe Val Val Pro Leu Ile Ala Ser Ala 
305                 310                 315                 320 


Ser Ile Lys Tyr Pro His Met Phe Ile Asn His Asn Gln Gln Val Ser 
                325                 330                 335     


Phe Lys Ala Tyr Ala Glu Lys Ile Val Met Lys Glu Val Thr Pro Leu 
            340                 345                 350         


Phe Asn Lys Gly Thr Met Pro Thr Pro Gln Gln Phe Gln Leu Thr Ile 
        355                 360                 365             


Glu Asn Ile Ala Asn Lys Tyr Leu Gln Asn Ala Ser 
    370                 375                 380 


<210>  6
<211>  701
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YopE1-138 - SopB

<400>  6

Met Lys Ile Ser Ser Phe Ile Ser Thr Ser Leu Pro Leu Pro Ala Ser 
1               5                   10                  15      


Val Ser Gly Ser Ser Ser Val Gly Glu Met Ser Gly Arg Ser Val Ser 
            20                  25                  30          


Gln Gln Lys Ser Asp Gln Tyr Ala Asn Asn Leu Ala Gly Arg Thr Glu 
        35                  40                  45              


Ser Pro Gln Gly Ser Ser Leu Ala Ser Arg Ile Ile Glu Arg Leu Ser 
    50                  55                  60                  


Ser Met Ala His Ser Val Ile Gly Phe Ile Gln Arg Met Phe Ser Glu 
65                  70                  75                  80  


Gly Ser His Lys Pro Val Val Thr Pro Ala Leu Thr Pro Ala Gln Met 
                85                  90                  95      


Pro Ser Pro Thr Ser Phe Ser Asp Ser Ile Lys Gln Leu Ala Ala Glu 
            100                 105                 110         


Thr Leu Pro Lys Tyr Met Gln Gln Leu Ser Ser Leu Asp Ala Glu Thr 
        115                 120                 125             


Leu Gln Lys Asn His Asp Gln Phe Ala Thr Leu Glu Met Gln Ile Gln 
    130                 135                 140                 


Ser Phe Tyr His Ser Ala Ser Leu Lys Thr Gln Glu Ala Phe Lys Ser 
145                 150                 155                 160 


Leu Gln Lys Thr Leu Tyr Asn Gly Met Gln Ile Leu Ser Gly Gln Gly 
                165                 170                 175     


Lys Ala Pro Ala Lys Ala Pro Asp Ala Arg Pro Glu Ile Ile Val Leu 
            180                 185                 190         


Arg Glu Pro Gly Ala Thr Trp Gly Asn Tyr Leu Gln His Gln Lys Ala 
        195                 200                 205             


Ser Asn His Ser Leu His Asn Leu Tyr Asn Leu Gln Arg Asp Leu Leu 
    210                 215                 220                 


Thr Val Ala Ala Thr Val Leu Gly Lys Gln Asp Pro Val Leu Thr Ser 
225                 230                 235                 240 


Met Ala Asn Gln Met Glu Leu Ala Lys Val Lys Ala Asp Arg Pro Ala 
                245                 250                 255     


Thr Lys Gln Glu Glu Ala Ala Ala Lys Ala Leu Lys Lys Asn Leu Ile 
            260                 265                 270         


Glu Leu Ile Ala Ala Arg Thr Gln Gln Gln Asp Gly Leu Pro Ala Lys 
        275                 280                 285             


Glu Ala His Arg Phe Ala Ala Val Ala Phe Arg Asp Ala Gln Val Lys 
    290                 295                 300                 


Gln Leu Asn Asn Gln Pro Trp Gln Thr Ile Lys Asn Thr Leu Thr His 
305                 310                 315                 320 


Asn Gly His His Tyr Thr Asn Thr Gln Leu Pro Ala Ala Glu Met Lys 
                325                 330                 335     


Ile Gly Ala Lys Asp Ile Phe Pro Ser Ala Tyr Glu Gly Lys Gly Val 
            340                 345                 350         


Cys Ser Trp Asp Thr Lys Asn Ile His His Ala Asn Asn Leu Trp Met 
        355                 360                 365             


Ser Thr Val Ser Val His Glu Asp Gly Lys Asp Lys Thr Leu Phe Cys 
    370                 375                 380                 


Gly Ile Arg His Gly Val Leu Ser Pro Tyr His Glu Lys Asp Pro Leu 
385                 390                 395                 400 


Leu Arg His Val Gly Ala Glu Asn Lys Ala Lys Glu Val Leu Thr Ala 
                405                 410                 415     


Ala Leu Phe Ser Lys Pro Glu Leu Leu Asn Lys Ala Leu Ala Gly Glu 
            420                 425                 430         


Ala Val Ser Leu Lys Leu Val Ser Val Gly Leu Leu Thr Ala Ser Asn 
        435                 440                 445             


Ile Phe Gly Lys Glu Gly Thr Met Val Glu Asp Gln Met Arg Ala Trp 
    450                 455                 460                 


Gln Ser Leu Thr Gln Pro Gly Lys Met Ile His Leu Lys Ile Arg Asn 
465                 470                 475                 480 


Lys Asp Gly Asp Leu Gln Thr Val Lys Ile Lys Pro Asp Val Ala Ala 
                485                 490                 495     


Phe Asn Val Gly Val Asn Glu Leu Ala Leu Lys Leu Gly Phe Gly Leu 
            500                 505                 510         


Lys Ala Ser Asp Ser Tyr Asn Ala Glu Ala Leu His Gln Leu Leu Gly 
        515                 520                 525             


Asn Asp Leu Arg Pro Glu Ala Arg Pro Gly Gly Trp Val Gly Glu Trp 
    530                 535                 540                 


Leu Ala Gln Tyr Pro Asp Asn Tyr Glu Val Val Asn Thr Leu Ala Arg 
545                 550                 555                 560 


Gln Ile Lys Asp Ile Trp Lys Asn Asn Gln His His Lys Asp Gly Gly 
                565                 570                 575     


Glu Pro Tyr Lys Leu Ala Gln Arg Leu Ala Met Leu Ala His Glu Ile 
            580                 585                 590         


Asp Ala Val Pro Ala Trp Asn Cys Lys Ser Gly Lys Asp Arg Thr Gly 
        595                 600                 605             


Met Met Asp Ser Glu Ile Lys Arg Glu Ile Ile Ser Leu His Gln Thr 
    610                 615                 620                 


His Met Leu Ser Ala Pro Gly Ser Leu Pro Asp Ser Gly Gly Gln Lys 
625                 630                 635                 640 


Ile Phe Gln Lys Val Leu Leu Asn Ser Gly Asn Leu Glu Ile Gln Lys 
                645                 650                 655     


Gln Asn Thr Gly Gly Ala Gly Asn Lys Val Met Lys Asn Leu Ser Pro 
            660                 665                 670         


Glu Val Leu Asn Leu Ser Tyr Gln Lys Arg Val Gly Asp Glu Asn Ile 
        675                 680                 685             


Trp Gln Ser Val Lys Gly Ile Ser Ser Leu Ile Thr Ser 
    690                 695                 700     


<210>  7
<211>  383
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YopE1-138 - OspF

<400>  7

Met Lys Ile Ser Ser Phe Ile Ser Thr Ser Leu Pro Leu Pro Ala Ser 
1               5                   10                  15      


Val Ser Gly Ser Ser Ser Val Gly Glu Met Ser Gly Arg Ser Val Ser 
            20                  25                  30          


Gln Gln Lys Ser Asp Gln Tyr Ala Asn Asn Leu Ala Gly Arg Thr Glu 
        35                  40                  45              


Ser Pro Gln Gly Ser Ser Leu Ala Ser Arg Ile Ile Glu Arg Leu Ser 
    50                  55                  60                  


Ser Met Ala His Ser Val Ile Gly Phe Ile Gln Arg Met Phe Ser Glu 
65                  70                  75                  80  


Gly Ser His Lys Pro Val Val Thr Pro Ala Leu Thr Pro Ala Gln Met 
                85                  90                  95      


Pro Ser Pro Thr Ser Phe Ser Asp Ser Ile Lys Gln Leu Ala Ala Glu 
            100                 105                 110         


Thr Leu Pro Lys Tyr Met Gln Gln Leu Ser Ser Leu Asp Ala Glu Thr 
        115                 120                 125             


Leu Gln Lys Asn His Asp Gln Phe Ala Thr Leu Glu Ser Arg Phe Glu 
    130                 135                 140                 


Met Pro Ile Lys Lys Pro Cys Leu Lys Leu Asn Leu Asp Ser Leu Asn 
145                 150                 155                 160 


Val Val Arg Ser Glu Ile Pro Gln Met Leu Ser Ala Asn Glu Arg Leu 
                165                 170                 175     


Lys Asn Asn Phe Asn Ile Leu Tyr Asn Gln Ile Arg Gln Tyr Pro Ala 
            180                 185                 190         


Tyr Tyr Phe Lys Val Ala Ser Asn Val Pro Thr Tyr Ser Asp Ile Cys 
        195                 200                 205             


Gln Ser Phe Ser Val Met Tyr Gln Gly Phe Gln Ile Val Asn His Ser 
    210                 215                 220                 


Gly Asp Val Phe Ile His Ala Cys Arg Glu Asn Pro Gln Ser Lys Gly 
225                 230                 235                 240 


Asp Phe Val Gly Asp Lys Phe His Ile Ser Ile Ala Arg Glu Gln Val 
                245                 250                 255     


Pro Leu Ala Phe Gln Ile Leu Ser Gly Leu Leu Phe Ser Glu Asp Ser 
            260                 265                 270         


Pro Ile Asp Lys Trp Lys Ile Thr Asp Met Asn Arg Val Ser Gln Gln 
        275                 280                 285             


Ser Arg Val Gly Ile Gly Ala Gln Phe Thr Leu Tyr Val Lys Ser Asp 
    290                 295                 300                 


Gln Glu Cys Ser Gln Tyr Ser Ala Leu Leu Leu His Lys Ile Arg Gln 
305                 310                 315                 320 


Phe Ile Met Cys Leu Glu Ser Asn Leu Leu Arg Ser Lys Ile Ala Pro 
                325                 330                 335     


Gly Glu Tyr Pro Ala Ser Asp Val Arg Pro Glu Asp Trp Lys Tyr Val 
            340                 345                 350         


Ser Tyr Arg Asn Glu Leu Arg Ser Asp Arg Asp Gly Ser Glu Arg Gln 
        355                 360                 365             


Glu Gln Met Leu Arg Glu Glu Pro Phe Tyr Arg Leu Met Ile Glu 
    370                 375                 380             


<210>  8
<211>  685
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YopE1-138 - SptP

<400>  8

Met Lys Ile Ser Ser Phe Ile Ser Thr Ser Leu Pro Leu Pro Ala Ser 
1               5                   10                  15      


Val Ser Gly Ser Ser Ser Val Gly Glu Met Ser Gly Arg Ser Val Ser 
            20                  25                  30          


Gln Gln Lys Ser Asp Gln Tyr Ala Asn Asn Leu Ala Gly Arg Thr Glu 
        35                  40                  45              


Ser Pro Gln Gly Ser Ser Leu Ala Ser Arg Ile Ile Glu Arg Leu Ser 
    50                  55                  60                  


Ser Met Ala His Ser Val Ile Gly Phe Ile Gln Arg Met Phe Ser Glu 
65                  70                  75                  80  


Gly Ser His Lys Pro Val Val Thr Pro Ala Leu Thr Pro Ala Gln Met 
                85                  90                  95      


Pro Ser Pro Thr Ser Phe Ser Asp Ser Ile Lys Gln Leu Ala Ala Glu 
            100                 105                 110         


Thr Leu Pro Lys Tyr Met Gln Gln Leu Ser Ser Leu Asp Ala Glu Thr 
        115                 120                 125             


Leu Gln Lys Asn His Asp Gln Phe Ala Thr Leu Glu Ser Arg Met Leu 
    130                 135                 140                 


Lys Tyr Glu Glu Arg Lys Leu Asn Asn Leu Thr Leu Ser Ser Phe Ser 
145                 150                 155                 160 


Lys Val Gly Val Ser Asn Asp Ala Arg Leu Tyr Ile Ala Lys Glu Asn 
                165                 170                 175     


Thr Asp Lys Ala Tyr Val Ala Pro Glu Lys Phe Ser Ser Lys Val Leu 
            180                 185                 190         


Thr Trp Leu Gly Lys Met Pro Leu Phe Lys Asn Thr Glu Val Val Gln 
        195                 200                 205             


Lys His Thr Glu Asn Ile Arg Val Gln Asp Gln Lys Ile Leu Gln Thr 
    210                 215                 220                 


Phe Leu His Ala Leu Thr Glu Lys Tyr Gly Glu Thr Ala Val Asn Asp 
225                 230                 235                 240 


Ala Leu Leu Met Ser Arg Ile Asn Met Asn Lys Pro Leu Thr Gln Arg 
                245                 250                 255     


Leu Ala Val Gln Ile Thr Glu Cys Val Lys Ala Ala Asp Glu Gly Phe 
            260                 265                 270         


Ile Asn Leu Ile Lys Ser Lys Asp Asn Val Gly Val Arg Asn Ala Ala 
        275                 280                 285             


Leu Val Ile Lys Gly Gly Asp Thr Lys Val Ala Glu Lys Asn Asn Asp 
    290                 295                 300                 


Val Gly Ala Glu Ser Lys Gln Pro Leu Leu Asp Ile Ala Leu Lys Gly 
305                 310                 315                 320 


Leu Lys Arg Thr Leu Pro Gln Leu Glu Gln Met Asp Gly Asn Ser Leu 
                325                 330                 335     


Arg Glu Asn Phe Gln Glu Met Ala Ser Gly Asn Gly Pro Leu Arg Ser 
            340                 345                 350         


Leu Met Thr Asn Leu Gln Asn Leu Asn Lys Ile Pro Glu Ala Lys Gln 
        355                 360                 365             


Leu Asn Asp Tyr Val Thr Thr Leu Thr Asn Ile Gln Val Gly Val Ala 
    370                 375                 380                 


Arg Phe Ser Gln Trp Gly Thr Cys Gly Gly Glu Val Glu Arg Trp Val 
385                 390                 395                 400 


Asp Lys Ala Ser Thr His Glu Leu Thr Gln Ala Val Lys Lys Ile His 
                405                 410                 415     


Val Ile Ala Lys Glu Leu Lys Asn Val Thr Ala Glu Leu Glu Lys Ile 
            420                 425                 430         


Glu Ala Gly Ala Pro Met Pro Gln Thr Met Ser Gly Pro Thr Leu Gly 
        435                 440                 445             


Leu Ala Arg Phe Ala Val Ser Ser Ile Pro Ile Asn Gln Gln Thr Gln 
    450                 455                 460                 


Val Lys Leu Ser Asp Gly Met Pro Val Pro Val Asn Thr Leu Thr Phe 
465                 470                 475                 480 


Asp Gly Lys Pro Val Ala Leu Ala Gly Ser Tyr Pro Lys Asn Thr Pro 
                485                 490                 495     


Asp Ala Leu Glu Ala His Met Lys Met Leu Leu Glu Lys Glu Cys Ser 
            500                 505                 510         


Cys Leu Val Val Leu Thr Ser Glu Asp Gln Met Gln Ala Lys Gln Leu 
        515                 520                 525             


Pro Pro Tyr Phe Arg Gly Ser Tyr Thr Phe Gly Glu Val His Thr Asn 
    530                 535                 540                 


Ser Gln Lys Val Ser Ser Ala Ser Gln Gly Glu Ala Ile Asp Gln Tyr 
545                 550                 555                 560 


Asn Met Gln Leu Ser Cys Gly Glu Lys Arg Tyr Thr Ile Pro Val Leu 
                565                 570                 575     


His Val Lys Asn Trp Pro Asp His Gln Pro Leu Pro Ser Thr Asp Gln 
            580                 585                 590         


Leu Glu Tyr Leu Ala Asp Arg Val Lys Asn Ser Asn Gln Asn Gly Ala 
        595                 600                 605             


Pro Gly Arg Ser Ser Ser Asp Lys His Leu Pro Met Ile His Cys Leu 
    610                 615                 620                 


Gly Gly Val Gly Arg Thr Gly Thr Met Ala Ala Ala Leu Val Leu Lys 
625                 630                 635                 640 


Asp Asn Pro His Ser Asn Leu Glu Gln Val Arg Ala Asp Phe Arg Asp 
                645                 650                 655     


Ser Arg Asn Asn Arg Met Leu Glu Asp Ala Ser Gln Phe Val Gln Leu 
            660                 665                 670         


Lys Ala Met Gln Ala Gln Leu Leu Met Thr Thr Ala Ser 
        675                 680                 685 


<210>  9
<211>  678
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YopE1-138 - IpgD

<400>  9

Met Lys Ile Ser Ser Phe Ile Ser Thr Ser Leu Pro Leu Pro Ala Ser 
1               5                   10                  15      


Val Ser Gly Ser Ser Ser Val Gly Glu Met Ser Gly Arg Ser Val Ser 
            20                  25                  30          


Gln Gln Lys Ser Asp Gln Tyr Ala Asn Asn Leu Ala Gly Arg Thr Glu 
        35                  40                  45              


Ser Pro Gln Gly Ser Ser Leu Ala Ser Arg Ile Ile Glu Arg Leu Ser 
    50                  55                  60                  


Ser Met Ala His Ser Val Ile Gly Phe Ile Gln Arg Met Phe Ser Glu 
65                  70                  75                  80  


Gly Ser His Lys Pro Val Val Thr Pro Ala Leu Thr Pro Ala Gln Met 
                85                  90                  95      


Pro Ser Pro Thr Ser Phe Ser Asp Ser Ile Lys Gln Leu Ala Ala Glu 
            100                 105                 110         


Thr Leu Pro Lys Tyr Met Gln Gln Leu Ser Ser Leu Asp Ala Glu Thr 
        115                 120                 125             


Leu Gln Lys Asn His Asp Gln Phe Ala Thr Leu Glu Met His Ile Thr 
    130                 135                 140                 


Asn Leu Gly Leu His Gln Val Ser Phe Gln Ser Gly Asp Ser Tyr Lys 
145                 150                 155                 160 


Gly Ala Glu Glu Thr Gly Lys His Lys Gly Val Ser Val Ile Ser Tyr 
                165                 170                 175     


Gln Arg Val Lys Asn Gly Glu Arg Asn Lys Gly Ile Glu Ala Leu Asn 
            180                 185                 190         


Arg Leu Tyr Leu Gln Asn Gln Thr Ser Leu Thr Gly Lys Ser Leu Leu 
        195                 200                 205             


Phe Ala Arg Asp Lys Ala Glu Val Phe Cys Glu Ala Ile Lys Leu Ala 
    210                 215                 220                 


Gly Gly Asp Thr Ser Lys Ile Lys Ala Met Met Glu Arg Leu Asp Thr 
225                 230                 235                 240 


Tyr Lys Leu Gly Glu Val Asn Lys Arg His Ile Asn Glu Leu Asn Lys 
                245                 250                 255     


Val Ile Ser Glu Glu Ile Arg Ala Gln Leu Gly Ile Lys Asn Lys Lys 
            260                 265                 270         


Glu Leu Gln Thr Lys Ile Lys Gln Ile Phe Thr Asp Tyr Leu Asn Asn 
        275                 280                 285             


Lys Asn Trp Gly Pro Val Asn Lys Asn Ile Ser His His Gly Lys Asn 
    290                 295                 300                 


Tyr Ser Phe Gln Leu Thr Pro Ala Ser His Met Lys Ile Gly Asn Lys 
305                 310                 315                 320 


Asn Ile Phe Val Lys Glu Tyr Asn Gly Lys Gly Ile Cys Cys Ala Ser 
                325                 330                 335     


Thr Arg Glu Arg Asp His Ile Ala Asn Met Trp Leu Ser Lys Val Val 
            340                 345                 350         


Asp Asp Glu Gly Lys Glu Ile Phe Ser Gly Ile Arg His Gly Val Ile 
        355                 360                 365             


Ser Ala Tyr Gly Leu Lys Lys Asn Ser Ser Glu Arg Ala Val Ala Ala 
    370                 375                 380                 


Arg Asn Lys Ala Glu Glu Leu Val Ser Ala Ala Leu Tyr Ser Arg Pro 
385                 390                 395                 400 


Glu Leu Leu Ser Gln Ala Leu Ser Gly Lys Thr Val Asp Leu Lys Ile 
                405                 410                 415     


Val Ser Thr Ser Leu Leu Thr Pro Thr Ser Leu Thr Gly Gly Glu Glu 
            420                 425                 430         


Ser Met Leu Lys Asp Gln Val Ser Ala Leu Lys Gly Leu Asn Ser Lys 
        435                 440                 445             


Arg Gly Gly Pro Thr Lys Leu Leu Ile Arg Asn Ser Asp Gly Leu Leu 
    450                 455                 460                 


Lys Glu Val Ser Val Asn Leu Lys Val Val Thr Phe Asn Phe Gly Val 
465                 470                 475                 480 


Asn Glu Leu Ala Leu Lys Met Gly Leu Gly Trp Arg Asn Val Asp Lys 
                485                 490                 495     


Leu Asn Asp Glu Ser Ile Cys Ser Leu Leu Gly Asp Asn Phe Leu Lys 
            500                 505                 510         


Asn Gly Val Ile Gly Gly Trp Ala Ala Glu Ala Ile Glu Lys Asn Pro 
        515                 520                 525             


Pro Cys Lys Asn Asp Val Ile Tyr Leu Ala Asn Gln Ile Lys Glu Ile 
    530                 535                 540                 


Val Asn Asn Lys Leu Gln Lys Asn Asp Asn Gly Glu Pro Tyr Lys Leu 
545                 550                 555                 560 


Ser Gln Arg Val Thr Leu Leu Ala Tyr Thr Ile Gly Ala Val Pro Cys 
                565                 570                 575     


Trp Asn Cys Lys Ser Gly Lys Asp Arg Thr Gly Met Gln Asp Ala Glu 
            580                 585                 590         


Ile Lys Arg Glu Ile Ile Arg Lys His Glu Thr Gly Gln Phe Ser Gln 
        595                 600                 605             


Leu Asn Ser Lys Leu Ser Ser Glu Glu Lys Arg Leu Phe Ser Thr Ile 
    610                 615                 620                 


Leu Met Asn Ser Gly Asn Met Glu Ile Gln Glu Met Asn Thr Gly Val 
625                 630                 635                 640 


Pro Gly Asn Lys Val Met Lys Lys Leu Pro Leu Ser Ser Leu Glu Leu 
                645                 650                 655     


Ser Tyr Ser Glu Arg Ile Gly Asp Pro Lys Ile Trp Asn Met Val Lys 
            660                 665                 670         


Gly Tyr Ser Ser Phe Val 
        675             


<210>  10
<211>  446
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YopE1-138 - BepA

<400>  10

Met Lys Ile Ser Ser Phe Ile Ser Thr Ser Leu Pro Leu Pro Ala Ser 
1               5                   10                  15      


Val Ser Gly Ser Ser Ser Val Gly Glu Met Ser Gly Arg Ser Val Ser 
            20                  25                  30          


Gln Gln Lys Ser Asp Gln Tyr Ala Asn Asn Leu Ala Gly Arg Thr Glu 
        35                  40                  45              


Ser Pro Gln Gly Ser Ser Leu Ala Ser Arg Ile Ile Glu Arg Leu Ser 
    50                  55                  60                  


Ser Met Ala His Ser Val Ile Gly Phe Ile Gln Arg Met Phe Ser Glu 
65                  70                  75                  80  


Gly Ser His Lys Pro Val Val Thr Pro Ala Leu Thr Pro Ala Gln Met 
                85                  90                  95      


Pro Ser Pro Thr Ser Phe Ser Asp Ser Ile Lys Gln Leu Ala Ala Glu 
            100                 105                 110         


Thr Leu Pro Lys Tyr Met Gln Gln Leu Ser Ser Leu Asp Ala Glu Thr 
        115                 120                 125             


Leu Gln Lys Asn His Asp Gln Phe Ala Thr Leu Glu Ser Arg Met Pro 
    130                 135                 140                 


Lys Ala Lys Ala Lys Thr Lys Asn Thr Glu Ile Ile Ser Pro His His 
145                 150                 155                 160 


Tyr Val Tyr Pro Asn Thr Thr Thr Leu Lys Asn Lys Tyr Gly Ile Lys 
                165                 170                 175     


Asn Leu Asn Ala Phe Leu Glu Lys Cys Ser His Asp Thr Ala Lys Ala 
            180                 185                 190         


Met Ile Asn Leu Arg Glu Glu Ser Leu Pro Glu Tyr Phe Asp Thr Ala 
        195                 200                 205             


Tyr Leu Cys His Ile His Gln Gln Leu Phe Lys Asn Thr Phe Glu Trp 
    210                 215                 220                 


Ala Gly Tyr Leu Arg His Ile Pro Phe Thr Phe Ala Asp Gly Thr Thr 
225                 230                 235                 240 


Ala Ala Met Pro Glu Met Lys Arg Thr Gly Trp Lys Asn Ala Phe Ala 
                245                 250                 255     


Ile Gly Asp Glu Ile Gln Glu Gly Leu Gln Arg Leu Asp Gln Thr Leu 
            260                 265                 270         


Ala Glu Lys Asn Asn Leu Gln Gly Leu Thr Arg Glu Glu Phe Asn Ser 
        275                 280                 285             


Glu Ala Ile Glu Leu Phe Asn Ser Leu Asn Gln Leu His Pro Phe Arg 
    290                 295                 300                 


Glu Gly Asn Gly Arg Thr Gln Arg Leu Phe Phe Glu Asn Leu Ala Lys 
305                 310                 315                 320 


Ala Ala Gly His Gln Leu Asn Phe Ser Leu Ile Thr Lys Glu Arg Met 
                325                 330                 335     


Met Val Ala Ser Val Ala Val Ala Glu Asn Gly Asp Leu Glu Pro Met 
            340                 345                 350         


Gln His Leu Phe Glu Asp Ile Ser Asn Pro Glu Lys Ile Arg Leu Leu 
        355                 360                 365             


Lys Glu Phe Met His Thr Met Lys Asn Thr Gly Arg Asn Val Asn Asp 
    370                 375                 380                 


Arg Pro Val Met Val Ala Lys Glu Gly Glu Thr Tyr Thr Gly Thr Tyr 
385                 390                 395                 400 


Arg Gly Ala Gly Leu Glu Gly Phe Ala Leu Asn Val Lys Gly Ala Tyr 
                405                 410                 415     


Ile Ile Gly Asn Ile Asp His Leu Pro Pro Glu Gln Leu Lys Ile Leu 
            420                 425                 430         


Lys Pro Gly Asp Lys Ile Thr Phe Thr Ala Pro Lys Ala Glu 
        435                 440                 445     


<210>  11
<211>  284
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YopE1-138 - BepA E305-end

<400>  11

Met Lys Ile Ser Ser Phe Ile Ser Thr Ser Leu Pro Leu Pro Ala Ser 
1               5                   10                  15      


Val Ser Gly Ser Ser Ser Val Gly Glu Met Ser Gly Arg Ser Val Ser 
            20                  25                  30          


Gln Gln Lys Ser Asp Gln Tyr Ala Asn Asn Leu Ala Gly Arg Thr Glu 
        35                  40                  45              


Ser Pro Gln Gly Ser Ser Leu Ala Ser Arg Ile Ile Glu Arg Leu Ser 
    50                  55                  60                  


Ser Met Ala His Ser Val Ile Gly Phe Ile Gln Arg Met Phe Ser Glu 
65                  70                  75                  80  


Gly Ser His Lys Pro Val Val Thr Pro Ala Leu Thr Pro Ala Gln Met 
                85                  90                  95      


Pro Ser Pro Thr Ser Phe Ser Asp Ser Ile Lys Gln Leu Ala Ala Glu 
            100                 105                 110         


Thr Leu Pro Lys Tyr Met Gln Gln Leu Ser Ser Leu Asp Ala Glu Thr 
        115                 120                 125             


Leu Gln Lys Asn His Asp Gln Phe Ala Thr Leu Glu Ser Arg Glu Gly 
    130                 135                 140                 


Asn Gly Arg Thr Gln Arg Leu Phe Phe Glu Asn Leu Ala Lys Ala Ala 
145                 150                 155                 160 


Gly His Gln Leu Asn Phe Ser Leu Ile Thr Lys Glu Arg Met Met Val 
                165                 170                 175     


Ala Ser Val Ala Val Ala Glu Asn Gly Asp Leu Glu Pro Met Gln His 
            180                 185                 190         


Leu Phe Glu Asp Ile Ser Asn Pro Glu Lys Ile Arg Leu Leu Lys Glu 
        195                 200                 205             


Phe Met His Thr Met Lys Asn Thr Gly Arg Asn Val Asn Asp Arg Pro 
    210                 215                 220                 


Val Met Val Ala Lys Glu Gly Glu Thr Tyr Thr Gly Thr Tyr Arg Gly 
225                 230                 235                 240 


Ala Gly Leu Glu Gly Phe Ala Leu Asn Val Lys Gly Ala Tyr Ile Ile 
                245                 250                 255     


Gly Asn Ile Asp His Leu Pro Pro Glu Gln Leu Lys Ile Leu Lys Pro 
            260                 265                 270         


Gly Asp Lys Ile Thr Phe Thr Ala Pro Lys Ala Glu 
        275                 280                 


<210>  12
<211>  672
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YopE1-138 - murine Traf6

<400>  12

Met Lys Ile Ser Ser Phe Ile Ser Thr Ser Leu Pro Leu Pro Ala Ser 
1               5                   10                  15      


Val Ser Gly Ser Ser Ser Val Gly Glu Met Ser Gly Arg Ser Val Ser 
            20                  25                  30          


Gln Gln Lys Ser Asp Gln Tyr Ala Asn Asn Leu Ala Gly Arg Thr Glu 
        35                  40                  45              


Ser Pro Gln Gly Ser Ser Leu Ala Ser Arg Ile Ile Glu Arg Leu Ser 
    50                  55                  60                  


Ser Met Ala His Ser Val Ile Gly Phe Ile Gln Arg Met Phe Ser Glu 
65                  70                  75                  80  


Gly Ser His Lys Pro Val Val Thr Pro Ala Leu Thr Pro Ala Gln Met 
                85                  90                  95      


Pro Ser Pro Thr Ser Phe Ser Asp Ser Ile Lys Gln Leu Ala Ala Glu 
            100                 105                 110         


Thr Leu Pro Lys Tyr Met Gln Gln Leu Ser Ser Leu Asp Ala Glu Thr 
        115                 120                 125             


Leu Gln Lys Asn His Asp Gln Phe Ala Thr Leu Glu Ser Arg Met Ser 
    130                 135                 140                 


Leu Leu Asn Cys Glu Asn Ser Cys Gly Ser Ser Gln Ser Ser Ser Asp 
145                 150                 155                 160 


Cys Cys Ala Ala Met Ala Ala Ser Cys Ser Ala Ala Val Lys Asp Asp 
                165                 170                 175     


Ser Val Ser Gly Ser Ala Ser Thr Gly Asn Leu Ser Ser Ser Phe Met 
            180                 185                 190         


Glu Glu Ile Gln Gly Tyr Asp Val Glu Phe Asp Pro Pro Leu Glu Ser 
        195                 200                 205             


Lys Tyr Glu Cys Pro Ile Cys Leu Met Ala Leu Arg Glu Ala Val Gln 
    210                 215                 220                 


Thr Pro Cys Gly His Arg Phe Cys Lys Ala Cys Ile Ile Lys Ser Ile 
225                 230                 235                 240 


Arg Asp Ala Gly His Lys Cys Pro Val Asp Asn Glu Ile Leu Leu Glu 
                245                 250                 255     


Asn Gln Leu Phe Pro Asp Asn Phe Ala Lys Arg Glu Ile Leu Ser Leu 
            260                 265                 270         


Thr Val Lys Cys Pro Asn Lys Gly Cys Leu Gln Lys Met Glu Leu Arg 
        275                 280                 285             


His Leu Glu Asp His Gln Val His Cys Glu Phe Ala Leu Val Asn Cys 
    290                 295                 300                 


Pro Gln Cys Gln Arg Pro Phe Gln Lys Cys Gln Val Asn Thr His Ile 
305                 310                 315                 320 


Ile Glu Asp Cys Pro Arg Arg Gln Val Ser Cys Val Asn Cys Ala Val 
                325                 330                 335     


Ser Met Ala Tyr Glu Glu Lys Glu Ile His Asp Gln Ser Cys Pro Leu 
            340                 345                 350         


Ala Asn Ile Ile Cys Glu Tyr Cys Gly Thr Ile Leu Ile Arg Glu Gln 
        355                 360                 365             


Met Pro Asn His Tyr Asp Leu Asp Cys Pro Thr Ala Pro Ile Pro Cys 
    370                 375                 380                 


Thr Phe Ser Val Phe Gly Cys His Gln Lys Met Gln Arg Asn His Leu 
385                 390                 395                 400 


Ala Arg His Leu Gln Glu Asn Thr Gln Leu His Met Arg Leu Leu Ala 
                405                 410                 415     


Gln Ala Val His Asn Val Asn Leu Ala Leu Arg Pro Cys Asp Ala Ala 
            420                 425                 430         


Ser Pro Ser Arg Gly Cys Arg Pro Glu Asp Pro Asn Tyr Glu Glu Thr 
        435                 440                 445             


Ile Lys Gln Leu Glu Ser Arg Leu Val Arg Gln Asp His Gln Ile Arg 
    450                 455                 460                 


Glu Leu Thr Ala Lys Met Glu Thr Gln Ser Met Tyr Val Gly Glu Leu 
465                 470                 475                 480 


Lys Arg Thr Ile Arg Thr Leu Glu Asp Lys Val Ala Glu Met Glu Ala 
                485                 490                 495     


Gln Gln Cys Asn Gly Ile Tyr Ile Trp Lys Ile Gly Lys Phe Gly Met 
            500                 505                 510         


His Leu Lys Ser Gln Glu Glu Glu Arg Pro Val Val Ile His Ser Pro 
        515                 520                 525             


Gly Phe Tyr Thr Gly Arg Pro Gly Tyr Lys Leu Cys Met Arg Leu His 
    530                 535                 540                 


Leu Gln Leu Pro Thr Ala Gln Arg Cys Ala Asn Tyr Ile Ser Leu Phe 
545                 550                 555                 560 


Val His Thr Met Gln Gly Glu Tyr Asp Ser His Leu Pro Trp Pro Phe 
                565                 570                 575     


Gln Gly Thr Ile Arg Leu Thr Ile Leu Asp Gln Ser Glu Ala Leu Ile 
            580                 585                 590         


Arg Gln Asn His Glu Glu Val Met Asp Ala Lys Pro Glu Leu Leu Ala 
        595                 600                 605             


Phe Gln Arg Pro Thr Ile Pro Arg Asn Pro Lys Gly Phe Gly Tyr Val 
    610                 615                 620                 


Thr Phe Met His Leu Glu Ala Leu Arg Gln Gly Thr Phe Ile Lys Asp 
625                 630                 635                 640 


Asp Thr Leu Leu Val Arg Cys Glu Val Ser Thr Arg Phe Asp Met Gly 
                645                 650                 655     


Gly Leu Arg Lys Glu Gly Phe Gln Pro Arg Ser Thr Asp Ala Gly Val 
            660                 665                 670         


<210>  13
<211>  326
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YopE1-138 - TIFA

<400>  13

Met Lys Ile Ser Ser Phe Ile Ser Thr Ser Leu Pro Leu Pro Ala Ser 
1               5                   10                  15      


Val Ser Gly Ser Ser Ser Val Gly Glu Met Ser Gly Arg Ser Val Ser 
            20                  25                  30          


Gln Gln Lys Ser Asp Gln Tyr Ala Asn Asn Leu Ala Gly Arg Thr Glu 
        35                  40                  45              


Ser Pro Gln Gly Ser Ser Leu Ala Ser Arg Ile Ile Glu Arg Leu Ser 
    50                  55                  60                  


Ser Met Ala His Ser Val Ile Gly Phe Ile Gln Arg Met Phe Ser Glu 
65                  70                  75                  80  


Gly Ser His Lys Pro Val Val Thr Pro Ala Leu Thr Pro Ala Gln Met 
                85                  90                  95      


Pro Ser Pro Thr Ser Phe Ser Asp Ser Ile Lys Gln Leu Ala Ala Glu 
            100                 105                 110         


Thr Leu Pro Lys Tyr Met Gln Gln Leu Ser Ser Leu Asp Ala Glu Thr 
        115                 120                 125             


Leu Gln Lys Asn His Asp Gln Phe Ala Thr Leu Glu Ser Arg Met Thr 
    130                 135                 140                 


Ser Phe Glu Asp Ala Asp Thr Glu Glu Thr Val Thr Cys Leu Gln Met 
145                 150                 155                 160 


Thr Val Tyr His Pro Gly Gln Leu Gln Cys Gly Ile Phe Gln Ser Ile 
                165                 170                 175     


Ser Phe Asn Arg Glu Lys Leu Pro Ser Ser Glu Val Val Lys Phe Gly 
            180                 185                 190         


Arg Asn Ser Asn Ile Cys His Tyr Thr Phe Gln Asp Lys Gln Val Ser 
        195                 200                 205             


Arg Val Gln Phe Ser Leu Gln Leu Phe Lys Lys Phe Asn Ser Ser Val 
    210                 215                 220                 


Leu Ser Phe Glu Ile Lys Asn Met Ser Lys Lys Thr Asn Leu Ile Val 
225                 230                 235                 240 


Asp Ser Arg Glu Leu Gly Tyr Leu Asn Lys Met Asp Leu Pro Tyr Arg 
                245                 250                 255     


Cys Met Val Arg Phe Gly Glu Tyr Gln Phe Leu Met Glu Lys Glu Asp 
            260                 265                 270         


Gly Glu Ser Leu Glu Phe Phe Glu Thr Gln Phe Ile Leu Ser Pro Arg 
        275                 280                 285             


Ser Leu Leu Gln Glu Asn Asn Trp Pro Pro His Arg Pro Ile Pro Glu 
    290                 295                 300                 


Tyr Gly Thr Tyr Ser Leu Cys Ser Ser Gln Ser Ser Ser Pro Thr Glu 
305                 310                 315                 320 


Met Asp Glu Asn Glu Ser 
                325     


<210>  14
<211>  437
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YopE1-138 - Cdk1

<400>  14

Met Lys Ile Ser Ser Phe Ile Ser Thr Ser Leu Pro Leu Pro Ala Ser 
1               5                   10                  15      


Val Ser Gly Ser Ser Ser Val Gly Glu Met Ser Gly Arg Ser Val Ser 
            20                  25                  30          


Gln Gln Lys Ser Asp Gln Tyr Ala Asn Asn Leu Ala Gly Arg Thr Glu 
        35                  40                  45              


Ser Pro Gln Gly Ser Ser Leu Ala Ser Arg Ile Ile Glu Arg Leu Ser 
    50                  55                  60                  


Ser Met Ala His Ser Val Ile Gly Phe Ile Gln Arg Met Phe Ser Glu 
65                  70                  75                  80  


Gly Ser His Lys Pro Val Val Thr Pro Ala Leu Thr Pro Ala Gln Met 
                85                  90                  95      


Pro Ser Pro Thr Ser Phe Ser Asp Ser Ile Lys Gln Leu Ala Ala Glu 
            100                 105                 110         


Thr Leu Pro Lys Tyr Met Gln Gln Leu Ser Ser Leu Asp Ala Glu Thr 
        115                 120                 125             


Leu Gln Lys Asn His Asp Gln Phe Ala Thr Leu Glu Met Glu Asp Tyr 
    130                 135                 140                 


Thr Lys Ile Glu Lys Ile Gly Glu Gly Thr Tyr Gly Val Val Tyr Lys 
145                 150                 155                 160 


Gly Arg His Lys Thr Thr Gly Gln Val Val Ala Met Lys Lys Ile Arg 
                165                 170                 175     


Leu Glu Ser Glu Glu Glu Gly Val Pro Ser Thr Ala Ile Arg Glu Ile 
            180                 185                 190         


Ser Leu Leu Lys Glu Leu Arg His Pro Asn Ile Val Ser Leu Gln Asp 
        195                 200                 205             


Val Leu Met Gln Asp Ser Arg Leu Tyr Leu Ile Phe Glu Phe Leu Ser 
    210                 215                 220                 


Met Asp Leu Lys Lys Tyr Leu Asp Ser Ile Pro Pro Gly Gln Tyr Met 
225                 230                 235                 240 


Asp Ser Ser Leu Val Lys Ser Tyr Leu Tyr Gln Ile Leu Gln Gly Ile 
                245                 250                 255     


Val Phe Cys His Ser Arg Arg Val Leu His Arg Asp Leu Lys Pro Gln 
            260                 265                 270         


Asn Leu Leu Ile Asp Asp Lys Gly Thr Ile Lys Leu Ala Asp Phe Gly 
        275                 280                 285             


Leu Ala Arg Ala Phe Gly Ile Pro Ile Arg Val Tyr Thr His Glu Val 
    290                 295                 300                 


Val Thr Leu Trp Tyr Arg Ser Pro Glu Val Leu Leu Gly Ser Ala Arg 
305                 310                 315                 320 


Tyr Ser Thr Pro Val Asp Ile Trp Ser Ile Gly Thr Ile Phe Ala Glu 
                325                 330                 335     


Leu Ala Thr Lys Lys Pro Leu Phe His Gly Asp Ser Glu Ile Asp Gln 
            340                 345                 350         


Leu Phe Arg Ile Phe Arg Ala Leu Gly Thr Pro Asn Asn Glu Val Trp 
        355                 360                 365             


Pro Glu Val Glu Ser Leu Gln Asp Tyr Lys Asn Thr Phe Pro Lys Trp 
    370                 375                 380                 


Lys Pro Gly Ser Leu Ala Ser His Val Lys Asn Leu Asp Glu Asn Gly 
385                 390                 395                 400 


Leu Asp Leu Leu Ser Lys Met Leu Ile Tyr Asp Pro Ala Lys Arg Ile 
                405                 410                 415     


Ser Gly Lys Met Ala Leu Asn His Pro Tyr Phe Asn Asp Leu Asp Asn 
            420                 425                 430         


Gln Ile Lys Lys Met 
        435         


<210>  15
<211>  347
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YopE1-138 - Mad2

<400>  15

Met Lys Ile Ser Ser Phe Ile Ser Thr Ser Leu Pro Leu Pro Ala Ser 
1               5                   10                  15      


Val Ser Gly Ser Ser Ser Val Gly Glu Met Ser Gly Arg Ser Val Ser 
            20                  25                  30          


Gln Gln Lys Ser Asp Gln Tyr Ala Asn Asn Leu Ala Gly Arg Thr Glu 
        35                  40                  45              


Ser Pro Gln Gly Ser Ser Leu Ala Ser Arg Ile Ile Glu Arg Leu Ser 
    50                  55                  60                  


Ser Met Ala His Ser Val Ile Gly Phe Ile Gln Arg Met Phe Ser Glu 
65                  70                  75                  80  


Gly Ser His Lys Pro Val Val Thr Pro Ala Leu Thr Pro Ala Gln Met 
                85                  90                  95      


Pro Ser Pro Thr Ser Phe Ser Asp Ser Ile Lys Gln Leu Ala Ala Glu 
            100                 105                 110         


Thr Leu Pro Lys Tyr Met Gln Gln Leu Ser Ser Leu Asp Ala Glu Thr 
        115                 120                 125             


Leu Gln Lys Asn His Asp Gln Phe Ala Thr Leu Glu Ser Arg Met Ala 
    130                 135                 140                 


Leu Gln Leu Ser Arg Glu Gln Gly Ile Thr Leu Arg Gly Ser Ala Glu 
145                 150                 155                 160 


Ile Val Ala Glu Phe Phe Ser Phe Gly Ile Asn Ser Ile Leu Tyr Gln 
                165                 170                 175     


Arg Gly Ile Tyr Pro Ser Glu Thr Phe Thr Arg Val Gln Lys Tyr Gly 
            180                 185                 190         


Leu Thr Leu Leu Val Thr Thr Asp Leu Glu Leu Ile Lys Tyr Leu Asn 
        195                 200                 205             


Asn Val Val Glu Gln Leu Lys Asp Trp Leu Tyr Lys Cys Ser Val Gln 
    210                 215                 220                 


Lys Leu Val Val Val Ile Ser Asn Ile Glu Ser Gly Glu Val Leu Glu 
225                 230                 235                 240 


Arg Trp Gln Phe Asp Ile Glu Cys Asp Lys Thr Ala Lys Asp Asp Ser 
                245                 250                 255     


Ala Pro Arg Glu Lys Ser Gln Lys Ala Ile Gln Asp Glu Ile Arg Ser 
            260                 265                 270         


Val Ile Arg Gln Ile Thr Ala Thr Val Thr Phe Leu Pro Leu Leu Glu 
        275                 280                 285             


Val Ser Cys Ser Phe Asp Leu Leu Ile Tyr Thr Asp Lys Asp Leu Val 
    290                 295                 300                 


Val Pro Glu Lys Trp Glu Glu Ser Gly Pro Gln Phe Ile Thr Asn Ser 
305                 310                 315                 320 


Glu Glu Val Arg Leu Arg Ser Phe Thr Thr Thr Ile His Lys Val Asn 
                325                 330                 335     


Ser Met Val Ala Tyr Lys Ile Pro Val Asn Asp 
            340                 345         


<210>  16
<211>  298
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YopE1-138 - Ink4A

<400>  16

Met Lys Ile Ser Ser Phe Ile Ser Thr Ser Leu Pro Leu Pro Ala Ser 
1               5                   10                  15      


Val Ser Gly Ser Ser Ser Val Gly Glu Met Ser Gly Arg Ser Val Ser 
            20                  25                  30          


Gln Gln Lys Ser Asp Gln Tyr Ala Asn Asn Leu Ala Gly Arg Thr Glu 
        35                  40                  45              


Ser Pro Gln Gly Ser Ser Leu Ala Ser Arg Ile Ile Glu Arg Leu Ser 
    50                  55                  60                  


Ser Met Ala His Ser Val Ile Gly Phe Ile Gln Arg Met Phe Ser Glu 
65                  70                  75                  80  


Gly Ser His Lys Pro Val Val Thr Pro Ala Leu Thr Pro Ala Gln Met 
                85                  90                  95      


Pro Ser Pro Thr Ser Phe Ser Asp Ser Ile Lys Gln Leu Ala Ala Glu 
            100                 105                 110         


Thr Leu Pro Lys Tyr Met Gln Gln Leu Ser Ser Leu Asp Ala Glu Thr 
        115                 120                 125             


Leu Gln Lys Asn His Asp Gln Phe Ala Thr Leu Glu Ser Arg Met Glu 
    130                 135                 140                 


Pro Ala Ala Gly Ser Ser Met Glu Pro Ser Ala Asp Trp Leu Ala Thr 
145                 150                 155                 160 


Ala Ala Ala Arg Gly Arg Val Glu Glu Val Arg Ala Leu Leu Glu Ala 
                165                 170                 175     


Gly Ala Leu Pro Asn Ala Pro Asn Ser Tyr Gly Arg Arg Pro Ile Gln 
            180                 185                 190         


Val Met Met Met Gly Ser Ala Arg Val Ala Glu Leu Leu Leu Leu His 
        195                 200                 205             


Gly Ala Glu Pro Asn Cys Ala Asp Pro Ala Thr Leu Thr Arg Pro Val 
    210                 215                 220                 


His Asp Ala Ala Arg Glu Gly Phe Leu Asp Thr Leu Val Val Leu His 
225                 230                 235                 240 


Arg Ala Gly Ala Arg Leu Asp Val Arg Asp Ala Trp Gly Arg Leu Pro 
                245                 250                 255     


Val Asp Leu Ala Glu Glu Leu Gly His Arg Asp Val Ala Arg Tyr Leu 
            260                 265                 270         


Arg Ala Ala Ala Gly Gly Thr Arg Gly Ser Asn His Ala Arg Ile Asp 
        275                 280                 285             


Ala Ala Glu Gly Pro Ser Asp Ile Pro Asp 
    290                 295             


<210>  17
<211>  280
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YopE1-138 - Ink4B

<400>  17

Met Lys Ile Ser Ser Phe Ile Ser Thr Ser Leu Pro Leu Pro Ala Ser 
1               5                   10                  15      


Val Ser Gly Ser Ser Ser Val Gly Glu Met Ser Gly Arg Ser Val Ser 
            20                  25                  30          


Gln Gln Lys Ser Asp Gln Tyr Ala Asn Asn Leu Ala Gly Arg Thr Glu 
        35                  40                  45              


Ser Pro Gln Gly Ser Ser Leu Ala Ser Arg Ile Ile Glu Arg Leu Ser 
    50                  55                  60                  


Ser Met Ala His Ser Val Ile Gly Phe Ile Gln Arg Met Phe Ser Glu 
65                  70                  75                  80  


Gly Ser His Lys Pro Val Val Thr Pro Ala Leu Thr Pro Ala Gln Met 
                85                  90                  95      


Pro Ser Pro Thr Ser Phe Ser Asp Ser Ile Lys Gln Leu Ala Ala Glu 
            100                 105                 110         


Thr Leu Pro Lys Tyr Met Gln Gln Leu Ser Ser Leu Asp Ala Glu Thr 
        115                 120                 125             


Leu Gln Lys Asn His Asp Gln Phe Ala Thr Leu Glu Ser Arg Met Arg 
    130                 135                 140                 


Glu Glu Asn Lys Gly Met Pro Ser Gly Gly Gly Ser Asp Glu Gly Leu 
145                 150                 155                 160 


Ala Ser Ala Ala Ala Arg Gly Leu Val Glu Lys Val Arg Gln Leu Leu 
                165                 170                 175     


Glu Ala Gly Ala Asp Pro Asn Gly Val Asn Arg Phe Gly Arg Arg Ala 
            180                 185                 190         


Ile Gln Val Met Met Met Gly Ser Ala Arg Val Ala Glu Leu Leu Leu 
        195                 200                 205             


Leu His Gly Ala Glu Pro Asn Cys Ala Asp Pro Ala Thr Leu Thr Arg 
    210                 215                 220                 


Pro Val His Asp Ala Ala Arg Glu Gly Phe Leu Asp Thr Leu Val Val 
225                 230                 235                 240 


Leu His Arg Ala Gly Ala Arg Leu Asp Val Arg Asp Ala Trp Gly Arg 
                245                 250                 255     


Leu Pro Val Asp Leu Ala Glu Glu Arg Gly His Arg Asp Val Ala Gly 
            260                 265                 270         


Tyr Leu Arg Thr Ala Thr Gly Asp 
        275                 280 


<210>  18
<211>  310
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YopE1-138 - Ink4C

<400>  18

Met Lys Ile Ser Ser Phe Ile Ser Thr Ser Leu Pro Leu Pro Ala Ser 
1               5                   10                  15      


Val Ser Gly Ser Ser Ser Val Gly Glu Met Ser Gly Arg Ser Val Ser 
            20                  25                  30          


Gln Gln Lys Ser Asp Gln Tyr Ala Asn Asn Leu Ala Gly Arg Thr Glu 
        35                  40                  45              


Ser Pro Gln Gly Ser Ser Leu Ala Ser Arg Ile Ile Glu Arg Leu Ser 
    50                  55                  60                  


Ser Met Ala His Ser Val Ile Gly Phe Ile Gln Arg Met Phe Ser Glu 
65                  70                  75                  80  


Gly Ser His Lys Pro Val Val Thr Pro Ala Leu Thr Pro Ala Gln Met 
                85                  90                  95      


Pro Ser Pro Thr Ser Phe Ser Asp Ser Ile Lys Gln Leu Ala Ala Glu 
            100                 105                 110         


Thr Leu Pro Lys Tyr Met Gln Gln Leu Ser Ser Leu Asp Ala Glu Thr 
        115                 120                 125             


Leu Gln Lys Asn His Asp Gln Phe Ala Thr Leu Glu Ser Arg Met Ala 
    130                 135                 140                 


Glu Pro Trp Gly Asn Glu Leu Ala Ser Ala Ala Ala Arg Gly Asp Leu 
145                 150                 155                 160 


Glu Gln Leu Thr Ser Leu Leu Gln Asn Asn Val Asn Val Asn Ala Gln 
                165                 170                 175     


Asn Gly Phe Gly Arg Thr Ala Leu Gln Val Met Lys Leu Gly Asn Pro 
            180                 185                 190         


Glu Ile Ala Arg Arg Leu Leu Leu Arg Gly Ala Asn Pro Asp Leu Lys 
        195                 200                 205             


Asp Arg Thr Gly Phe Ala Val Ile His Asp Ala Ala Arg Ala Gly Phe 
    210                 215                 220                 


Leu Asp Thr Leu Gln Ala Leu Pro Glu Phe Gln Ala Asp Val Asn Ile 
225                 230                 235                 240 


Glu Asp Asn Glu Gly Asn Leu Pro Leu His Leu Ala Ala Lys Glu Gly 
                245                 250                 255     


His Leu Arg Val Val Glu Phe Leu Val Lys His Thr Ala Ser Asn Val 
            260                 265                 270         


Gly His Arg Asn His Lys Gly Asp Thr Ala Cys Asp Leu Ala Arg Leu 
        275                 280                 285             


Tyr Gly Arg Asn Glu Val Val Ser Leu Met Gln Ala Asn Gly Ala Gly 
    290                 295                 300                 


Gly Ala Thr Asn Leu Gln 
305                 310 


<210>  19
<211>  329
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YopE1-138 - z-Bid

<400>  19

Met Lys Ile Ser Ser Phe Ile Ser Thr Ser Leu Pro Leu Pro Ala Ser 
1               5                   10                  15      


Val Ser Gly Ser Ser Ser Val Gly Glu Met Ser Gly Arg Ser Val Ser 
            20                  25                  30          


Gln Gln Lys Ser Asp Gln Tyr Ala Asn Asn Leu Ala Gly Arg Thr Glu 
        35                  40                  45              


Ser Pro Gln Gly Ser Ser Leu Ala Ser Arg Ile Ile Glu Arg Leu Ser 
    50                  55                  60                  


Ser Met Ala His Ser Val Ile Gly Phe Ile Gln Arg Met Phe Ser Glu 
65                  70                  75                  80  


Gly Ser His Lys Pro Val Val Thr Pro Ala Leu Thr Pro Ala Gln Met 
                85                  90                  95      


Pro Ser Pro Thr Ser Phe Ser Asp Ser Ile Lys Gln Leu Ala Ala Glu 
            100                 105                 110         


Thr Leu Pro Lys Tyr Met Gln Gln Leu Ser Ser Leu Asp Ala Glu Thr 
        115                 120                 125             


Leu Gln Lys Asn His Asp Gln Phe Ala Thr Leu Glu Ser Arg Met Asp 
    130                 135                 140                 


Phe Asn Arg Asn Phe Asp His Ile Pro His Thr Ser Leu Val Leu Leu 
145                 150                 155                 160 


Ser Phe Leu Asn Gln Lys Asp Cys Gln Asn Gly Glu Ser Gly Arg Val 
                165                 170                 175     


Phe Asp Tyr Arg Glu Asp Asn Leu Ser Thr Asn His Ile Asp Ser Asp 
            180                 185                 190         


Gly Asp Ile Glu Thr Asp Gly His Ser Pro Pro Ala Thr Tyr Arg Asp 
        195                 200                 205             


Leu Leu His Glu Leu Gln His Glu Val Gln Pro Gly Leu Ser Val Asn 
    210                 215                 220                 


Ala Glu Glu Ala Arg Ala Ala Arg Glu Met Ala Ala Glu Leu Ile Arg 
225                 230                 235                 240 


Ile Ala Asp Leu Leu Glu Gln Ser Val Leu Ser Gln Ala Ala Glu Ser 
                245                 250                 255     


Leu Thr Lys Lys Leu Arg Ser Phe Gln Glu Gln Val Trp Ala Ser His 
            260                 265                 270         


Leu Ser Lys Gly Val Gln Thr Leu Leu Gln His Val Ala Ala Ala Lys 
        275                 280                 285             


Glu Phe Lys Lys Glu Leu Val Glu Met Ala Phe Thr Phe Met Leu Met 
    290                 295                 300                 


Lys Thr Val Cys Glu Arg Thr Pro Asp Phe Leu Phe Gly Leu Tyr Gly 
305                 310                 315                 320 


Thr Val Val Gln Phe Phe Gly Ser Asn 
                325                 


<210>  20
<211>  273
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YopE1-138 - z-t-Bid

<400>  20

Met Lys Ile Ser Ser Phe Ile Ser Thr Ser Leu Pro Leu Pro Ala Ser 
1               5                   10                  15      


Val Ser Gly Ser Ser Ser Val Gly Glu Met Ser Gly Arg Ser Val Ser 
            20                  25                  30          


Gln Gln Lys Ser Asp Gln Tyr Ala Asn Asn Leu Ala Gly Arg Thr Glu 
        35                  40                  45              


Ser Pro Gln Gly Ser Ser Leu Ala Ser Arg Ile Ile Glu Arg Leu Ser 
    50                  55                  60                  


Ser Met Ala His Ser Val Ile Gly Phe Ile Gln Arg Met Phe Ser Glu 
65                  70                  75                  80  


Gly Ser His Lys Pro Val Val Thr Pro Ala Leu Thr Pro Ala Gln Met 
                85                  90                  95      


Pro Ser Pro Thr Ser Phe Ser Asp Ser Ile Lys Gln Leu Ala Ala Glu 
            100                 105                 110         


Thr Leu Pro Lys Tyr Met Gln Gln Leu Ser Ser Leu Asp Ala Glu Thr 
        115                 120                 125             


Leu Gln Lys Asn His Asp Gln Phe Ala Thr Leu Glu Ser Arg Gly His 
    130                 135                 140                 


Ser Pro Pro Ala Thr Tyr Arg Asp Leu Leu His Glu Leu Gln His Glu 
145                 150                 155                 160 


Val Gln Pro Gly Leu Ser Val Asn Ala Glu Glu Ala Arg Ala Ala Arg 
                165                 170                 175     


Glu Met Ala Ala Glu Leu Ile Arg Ile Ala Asp Leu Leu Glu Gln Ser 
            180                 185                 190         


Val Leu Ser Gln Ala Ala Glu Ser Leu Thr Lys Lys Leu Arg Ser Phe 
        195                 200                 205             


Gln Glu Gln Val Trp Ala Ser His Leu Ser Lys Gly Val Gln Thr Leu 
    210                 215                 220                 


Leu Gln His Val Ala Ala Ala Lys Glu Phe Lys Lys Glu Leu Val Glu 
225                 230                 235                 240 


Met Ala Phe Thr Phe Met Leu Met Lys Thr Val Cys Glu Arg Thr Pro 
                245                 250                 255     


Asp Phe Leu Phe Gly Leu Tyr Gly Thr Val Val Gln Phe Phe Gly Ser 
            260                 265                 270         


Asn 
    


<210>  21
<211>  318
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YopE1-138 - z-BIM

<400>  21

Met Lys Ile Ser Ser Phe Ile Ser Thr Ser Leu Pro Leu Pro Ala Ser 
1               5                   10                  15      


Val Ser Gly Ser Ser Ser Val Gly Glu Met Ser Gly Arg Ser Val Ser 
            20                  25                  30          


Gln Gln Lys Ser Asp Gln Tyr Ala Asn Asn Leu Ala Gly Arg Thr Glu 
        35                  40                  45              


Ser Pro Gln Gly Ser Ser Leu Ala Ser Arg Ile Ile Glu Arg Leu Ser 
    50                  55                  60                  


Ser Met Ala His Ser Val Ile Gly Phe Ile Gln Arg Met Phe Ser Glu 
65                  70                  75                  80  


Gly Ser His Lys Pro Val Val Thr Pro Ala Leu Thr Pro Ala Gln Met 
                85                  90                  95      


Pro Ser Pro Thr Ser Phe Ser Asp Ser Ile Lys Gln Leu Ala Ala Glu 
            100                 105                 110         


Thr Leu Pro Lys Tyr Met Gln Gln Leu Ser Ser Leu Asp Ala Glu Thr 
        115                 120                 125             


Leu Gln Lys Asn His Asp Gln Phe Ala Thr Leu Glu Ser Arg Met Ser 
    130                 135                 140                 


Asp Thr Ser Arg Glu Gln Thr Leu Ala Asn Gly Pro Ala Ser Gln Gly 
145                 150                 155                 160 


Ser Gly Glu Ser Thr Gly Gly Gly Val Val Leu Pro Ala Gly His Phe 
                165                 170                 175     


Asp Phe Pro Gln Pro Gly Glu Gly Asp Pro Leu Arg Gly Gly Ile Ser 
            180                 185                 190         


Met Ser Asn Asn Gln Ser Arg Ser Pro Met Asn Arg Thr Phe Ser Arg 
        195                 200                 205             


Ser Ser Ser Gly Tyr Phe Ser Val Asp Ser Asp Ser Val Pro Gly Ser 
    210                 215                 220                 


Pro Leu Met Pro Asn Ile Ser Glu Ala Gln Asp Gly Gln Asn Asp Glu 
225                 230                 235                 240 


Val Trp Leu Ser Glu His Ser His Gln His Leu Gln Met Ala Ala Pro 
                245                 250                 255     


Val Ala Ala Leu Pro Pro Glu Met Val Val Ala Arg Glu Leu Arg Arg 
            260                 265                 270         


Ile Gly Asp Glu Phe Asn Arg Leu Tyr Cys Glu Ala Gly Ala Gly Val 
        275                 280                 285             


Asn Gln Leu Arg Ala Pro Asn Glu His Ala Ile Val Leu Trp Met Asn 
    290                 295                 300                 


Val Ile Ile Gly Arg Leu Val His Phe Phe Leu Arg Arg Arg 
305                 310                 315             


<210>  22
<211>  289
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YopE1-138 - Caspase3 p17

<400>  22

Met Lys Ile Ser Ser Phe Ile Ser Thr Ser Leu Pro Leu Pro Ala Ser 
1               5                   10                  15      


Val Ser Gly Ser Ser Ser Val Gly Glu Met Ser Gly Arg Ser Val Ser 
            20                  25                  30          


Gln Gln Lys Ser Asp Gln Tyr Ala Asn Asn Leu Ala Gly Arg Thr Glu 
        35                  40                  45              


Ser Pro Gln Gly Ser Ser Leu Ala Ser Arg Ile Ile Glu Arg Leu Ser 
    50                  55                  60                  


Ser Met Ala His Ser Val Ile Gly Phe Ile Gln Arg Met Phe Ser Glu 
65                  70                  75                  80  


Gly Ser His Lys Pro Val Val Thr Pro Ala Leu Thr Pro Ala Gln Met 
                85                  90                  95      


Pro Ser Pro Thr Ser Phe Ser Asp Ser Ile Lys Gln Leu Ala Ala Glu 
            100                 105                 110         


Thr Leu Pro Lys Tyr Met Gln Gln Leu Ser Ser Leu Asp Ala Glu Thr 
        115                 120                 125             


Leu Gln Lys Asn His Asp Gln Phe Ala Thr Leu Glu Ser Arg Ser Gly 
    130                 135                 140                 


Ile Ser Leu Asp Asn Ser Tyr Lys Met Asp Tyr Pro Glu Met Gly Leu 
145                 150                 155                 160 


Cys Ile Ile Ile Asn Asn Lys Asn Phe His Lys Ser Thr Gly Met Thr 
                165                 170                 175     


Ser Arg Ser Gly Thr Asp Val Asp Ala Ala Asn Leu Arg Glu Thr Phe 
            180                 185                 190         


Arg Asn Leu Lys Tyr Glu Val Arg Asn Lys Asn Asp Leu Thr Arg Glu 
        195                 200                 205             


Glu Ile Val Glu Leu Met Arg Asp Val Ser Lys Glu Asp His Ser Lys 
    210                 215                 220                 


Arg Ser Ser Phe Val Cys Val Leu Leu Ser His Gly Glu Glu Gly Ile 
225                 230                 235                 240 


Ile Phe Gly Thr Asn Gly Pro Val Asp Leu Lys Lys Ile Thr Asn Phe 
                245                 250                 255     


Phe Arg Gly Asp Arg Cys Arg Ser Leu Thr Gly Lys Pro Lys Leu Phe 
            260                 265                 270         


Ile Ile Gln Ala Cys Arg Gly Thr Glu Leu Asp Cys Gly Ile Glu Thr 
        275                 280                 285             


Asp 
    


<210>  23
<211>  242
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YopE1-138 - Caspase3 p10/12

<400>  23

Met Lys Ile Ser Ser Phe Ile Ser Thr Ser Leu Pro Leu Pro Ala Ser 
1               5                   10                  15      


Val Ser Gly Ser Ser Ser Val Gly Glu Met Ser Gly Arg Ser Val Ser 
            20                  25                  30          


Gln Gln Lys Ser Asp Gln Tyr Ala Asn Asn Leu Ala Gly Arg Thr Glu 
        35                  40                  45              


Ser Pro Gln Gly Ser Ser Leu Ala Ser Arg Ile Ile Glu Arg Leu Ser 
    50                  55                  60                  


Ser Met Ala His Ser Val Ile Gly Phe Ile Gln Arg Met Phe Ser Glu 
65                  70                  75                  80  


Gly Ser His Lys Pro Val Val Thr Pro Ala Leu Thr Pro Ala Gln Met 
                85                  90                  95      


Pro Ser Pro Thr Ser Phe Ser Asp Ser Ile Lys Gln Leu Ala Ala Glu 
            100                 105                 110         


Thr Leu Pro Lys Tyr Met Gln Gln Leu Ser Ser Leu Asp Ala Glu Thr 
        115                 120                 125             


Leu Gln Lys Asn His Asp Gln Phe Ala Thr Leu Glu Ser Gly Val Asp 
    130                 135                 140                 


Asp Asp Met Ala Cys His Lys Ile Pro Val Glu Ala Asp Phe Leu Tyr 
145                 150                 155                 160 


Ala Tyr Ser Thr Ala Pro Gly Tyr Tyr Ser Trp Arg Asn Ser Lys Asp 
                165                 170                 175     


Gly Ser Trp Phe Ile Gln Ser Leu Cys Ala Met Leu Lys Gln Tyr Ala 
            180                 185                 190         


Asp Lys Leu Glu Phe Met His Ile Leu Thr Arg Val Asn Arg Lys Val 
        195                 200                 205             


Ala Thr Glu Phe Glu Ser Phe Ser Phe Asp Ala Thr Phe His Ala Lys 
    210                 215                 220                 


Lys Gln Ile Pro Cys Ile Val Ser Met Leu Thr Lys Glu Leu Tyr Phe 
225                 230                 235                 240 


Tyr His 
        


<210>  24
<211>  337
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YopE1-138 - human Bid

<400>  24

Met Lys Ile Ser Ser Phe Ile Ser Thr Ser Leu Pro Leu Pro Ala Ser 
1               5                   10                  15      


Val Ser Gly Ser Ser Ser Val Gly Glu Met Ser Gly Arg Ser Val Ser 
            20                  25                  30          


Gln Gln Lys Ser Asp Gln Tyr Ala Asn Asn Leu Ala Gly Arg Thr Glu 
        35                  40                  45              


Ser Pro Gln Gly Ser Ser Leu Ala Ser Arg Ile Ile Glu Arg Leu Ser 
    50                  55                  60                  


Ser Met Ala His Ser Val Ile Gly Phe Ile Gln Arg Met Phe Ser Glu 
65                  70                  75                  80  


Gly Ser His Lys Pro Val Val Thr Pro Ala Leu Thr Pro Ala Gln Met 
                85                  90                  95      


Pro Ser Pro Thr Ser Phe Ser Asp Ser Ile Lys Gln Leu Ala Ala Glu 
            100                 105                 110         


Thr Leu Pro Lys Tyr Met Gln Gln Leu Ser Ser Leu Asp Ala Glu Thr 
        115                 120                 125             


Leu Gln Lys Asn His Asp Gln Phe Ala Thr Leu Glu Ser Arg Met Asp 
    130                 135                 140                 


Cys Glu Val Asn Asn Gly Ser Ser Leu Arg Asp Glu Cys Ile Thr Asn 
145                 150                 155                 160 


Leu Leu Val Phe Gly Phe Leu Gln Ser Cys Ser Asp Asn Ser Phe Arg 
                165                 170                 175     


Arg Glu Leu Asp Ala Leu Gly His Glu Leu Pro Val Leu Ala Pro Gln 
            180                 185                 190         


Trp Glu Gly Tyr Asp Glu Leu Gln Thr Asp Gly Asn Arg Ser Ser His 
        195                 200                 205             


Ser Arg Leu Gly Arg Ile Glu Ala Asp Ser Glu Ser Gln Glu Asp Ile 
    210                 215                 220                 


Ile Arg Asn Ile Ala Arg His Leu Ala Gln Val Gly Asp Ser Met Asp 
225                 230                 235                 240 


Arg Ser Ile Pro Pro Gly Leu Val Asn Gly Leu Ala Leu Gln Leu Arg 
                245                 250                 255     


Asn Thr Ser Arg Ser Glu Glu Asp Arg Asn Arg Asp Leu Ala Thr Ala 
            260                 265                 270         


Leu Glu Gln Leu Leu Gln Ala Tyr Pro Arg Asp Met Glu Lys Glu Lys 
        275                 280                 285             


Thr Met Leu Val Leu Ala Leu Leu Leu Ala Lys Lys Val Ala Ser His 
    290                 295                 300                 


Thr Pro Ser Leu Leu Arg Asp Val Phe His Thr Thr Val Asn Phe Ile 
305                 310                 315                 320 


Asn Gln Asn Leu Arg Thr Tyr Val Arg Ser Leu Ala Arg Asn Gly Met 
                325                 330                 335     


Asp 
    


<210>  25
<211>  277
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YopE1-138 - human t-Bid

<400>  25

Met Lys Ile Ser Ser Phe Ile Ser Thr Ser Leu Pro Leu Pro Ala Ser 
1               5                   10                  15      


Val Ser Gly Ser Ser Ser Val Gly Glu Met Ser Gly Arg Ser Val Ser 
            20                  25                  30          


Gln Gln Lys Ser Asp Gln Tyr Ala Asn Asn Leu Ala Gly Arg Thr Glu 
        35                  40                  45              


Ser Pro Gln Gly Ser Ser Leu Ala Ser Arg Ile Ile Glu Arg Leu Ser 
    50                  55                  60                  


Ser Met Ala His Ser Val Ile Gly Phe Ile Gln Arg Met Phe Ser Glu 
65                  70                  75                  80  


Gly Ser His Lys Pro Val Val Thr Pro Ala Leu Thr Pro Ala Gln Met 
                85                  90                  95      


Pro Ser Pro Thr Ser Phe Ser Asp Ser Ile Lys Gln Leu Ala Ala Glu 
            100                 105                 110         


Thr Leu Pro Lys Tyr Met Gln Gln Leu Ser Ser Leu Asp Ala Glu Thr 
        115                 120                 125             


Leu Gln Lys Asn His Asp Gln Phe Ala Thr Leu Glu Ser Arg Gly Asn 
    130                 135                 140                 


Arg Ser Ser His Ser Arg Leu Gly Arg Ile Glu Ala Asp Ser Glu Ser 
145                 150                 155                 160 


Gln Glu Asp Ile Ile Arg Asn Ile Ala Arg His Leu Ala Gln Val Gly 
                165                 170                 175     


Asp Ser Met Asp Arg Ser Ile Pro Pro Gly Leu Val Asn Gly Leu Ala 
            180                 185                 190         


Leu Gln Leu Arg Asn Thr Ser Arg Ser Glu Glu Asp Arg Asn Arg Asp 
        195                 200                 205             


Leu Ala Thr Ala Leu Glu Gln Leu Leu Gln Ala Tyr Pro Arg Asp Met 
    210                 215                 220                 


Glu Lys Glu Lys Thr Met Leu Val Leu Ala Leu Leu Leu Ala Lys Lys 
225                 230                 235                 240 


Val Ala Ser His Thr Pro Ser Leu Leu Arg Asp Val Phe His Thr Thr 
                245                 250                 255     


Val Asn Phe Ile Asn Gln Asn Leu Arg Thr Tyr Val Arg Ser Leu Ala 
            260                 265                 270         


Arg Asn Gly Met Asp 
        275         


<210>  26
<211>  327
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YopE1-138 - Rac1 Q61E

<400>  26

Met Lys Ile Ser Ser Phe Ile Ser Thr Ser Leu Pro Leu Pro Ala Ser 
1               5                   10                  15      


Val Ser Gly Ser Ser Ser Val Gly Glu Met Ser Gly Arg Ser Val Ser 
            20                  25                  30          


Gln Gln Lys Ser Asp Gln Tyr Ala Asn Asn Leu Ala Gly Arg Thr Glu 
        35                  40                  45              


Ser Pro Gln Gly Ser Ser Leu Ala Ser Arg Ile Ile Glu Arg Leu Ser 
    50                  55                  60                  


Ser Met Ala His Ser Val Ile Gly Phe Ile Gln Arg Met Phe Ser Glu 
65                  70                  75                  80  


Gly Ser His Lys Pro Val Val Thr Pro Ala Leu Thr Pro Ala Gln Met 
                85                  90                  95      


Pro Ser Pro Thr Ser Phe Ser Asp Ser Ile Lys Gln Leu Ala Ala Glu 
            100                 105                 110         


Thr Leu Pro Lys Tyr Met Gln Gln Leu Ser Ser Leu Asp Ala Glu Thr 
        115                 120                 125             


Leu Gln Lys Asn His Asp Gln Phe Ala Thr Leu Glu Gln Ala Ile Lys 
    130                 135                 140                 


Cys Val Val Val Gly Asp Gly Ala Val Gly Lys Thr Cys Leu Leu Ile 
145                 150                 155                 160 


Ser Tyr Thr Thr Asn Ala Phe Pro Gly Glu Tyr Ile Pro Thr Val Phe 
                165                 170                 175     


Asp Asn Tyr Ser Ala Asn Val Met Val Asp Gly Lys Pro Val Asn Leu 
            180                 185                 190         


Gly Leu Trp Asp Thr Ala Gly Glu Glu Asp Tyr Asp Arg Leu Arg Pro 
        195                 200                 205             


Leu Ser Tyr Pro Gln Thr Asp Val Phe Leu Ile Cys Phe Ser Leu Val 
    210                 215                 220                 


Ser Pro Ala Ser Phe Glu Asn Val Arg Ala Lys Trp Tyr Pro Glu Val 
225                 230                 235                 240 


Arg His His Cys Pro Asn Thr Pro Ile Ile Leu Val Gly Thr Lys Leu 
                245                 250                 255     


Asp Leu Arg Asp Asp Lys Asp Thr Ile Glu Lys Leu Lys Glu Lys Lys 
            260                 265                 270         


Leu Thr Pro Ile Thr Tyr Pro Gln Gly Leu Ala Met Ala Lys Glu Ile 
        275                 280                 285             


Gly Ala Val Lys Tyr Leu Glu Cys Ser Ala Leu Thr Gln Arg Gly Leu 
    290                 295                 300                 


Lys Thr Val Phe Asp Glu Ala Ile Arg Ala Val Leu Cys Pro Pro Pro 
305                 310                 315                 320 


Val Lys Lys Arg Lys Arg Lys 
                325         


<210>  27
<211>  333
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YopE1-138 - RhoA Q63L

<400>  27

Met Lys Ile Ser Ser Phe Ile Ser Thr Ser Leu Pro Leu Pro Ala Ser 
1               5                   10                  15      


Val Ser Gly Ser Ser Ser Val Gly Glu Met Ser Gly Arg Ser Val Ser 
            20                  25                  30          


Gln Gln Lys Ser Asp Gln Tyr Ala Asn Asn Leu Ala Gly Arg Thr Glu 
        35                  40                  45              


Ser Pro Gln Gly Ser Ser Leu Ala Ser Arg Ile Ile Glu Arg Leu Ser 
    50                  55                  60                  


Ser Met Ala His Ser Val Ile Gly Phe Ile Gln Arg Met Phe Ser Glu 
65                  70                  75                  80  


Gly Ser His Lys Pro Val Val Thr Pro Ala Leu Thr Pro Ala Gln Met 
                85                  90                  95      


Pro Ser Pro Thr Ser Phe Ser Asp Ser Ile Lys Gln Leu Ala Ala Glu 
            100                 105                 110         


Thr Leu Pro Lys Tyr Met Gln Gln Leu Ser Ser Leu Asp Ala Glu Thr 
        115                 120                 125             


Leu Gln Lys Asn His Asp Gln Phe Ala Thr Leu Glu Met Ala Ala Ile 
    130                 135                 140                 


Arg Lys Lys Leu Val Ile Val Gly Asp Gly Ala Cys Gly Lys Thr Cys 
145                 150                 155                 160 


Leu Leu Ile Val Phe Ser Lys Asp Gln Phe Pro Glu Val Tyr Val Pro 
                165                 170                 175     


Thr Val Phe Glu Asn Tyr Val Ala Asp Ile Glu Val Asp Gly Lys Gln 
            180                 185                 190         


Val Glu Leu Ala Leu Trp Asp Thr Ala Gly Leu Glu Asp Tyr Asp Arg 
        195                 200                 205             


Leu Arg Pro Leu Ser Tyr Pro Asp Thr Asp Val Ile Leu Met Cys Phe 
    210                 215                 220                 


Ser Ile Asp Ser Pro Asp Ser Leu Glu Asn Ile Pro Glu Lys Trp Thr 
225                 230                 235                 240 


Pro Glu Val Lys His Phe Cys Pro Asn Val Pro Ile Ile Leu Val Gly 
                245                 250                 255     


Asn Lys Lys Asp Leu Arg Asn Asp Glu His Thr Arg Arg Glu Leu Ala 
            260                 265                 270         


Lys Met Lys Gln Glu Pro Val Lys Pro Glu Glu Gly Arg Asp Met Ala 
        275                 280                 285             


Asn Arg Ile Gly Ala Phe Gly Tyr Met Glu Cys Ser Ala Lys Thr Lys 
    290                 295                 300                 


Asp Gly Val Arg Glu Val Phe Glu Met Ala Thr Arg Ala Ala Leu Gln 
305                 310                 315                 320 


Ala Arg Arg Gly Lys Lys Lys Ser Gly Cys Leu Val Leu 
                325                 330             


<210>  28
<211>  350
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YopE1-138 - FADD

<400>  28

Met Lys Ile Ser Ser Phe Ile Ser Thr Ser Leu Pro Leu Pro Ala Ser 
1               5                   10                  15      


Val Ser Gly Ser Ser Ser Val Gly Glu Met Ser Gly Arg Ser Val Ser 
            20                  25                  30          


Gln Gln Lys Ser Asp Gln Tyr Ala Asn Asn Leu Ala Gly Arg Thr Glu 
        35                  40                  45              


Ser Pro Gln Gly Ser Ser Leu Ala Ser Arg Ile Ile Glu Arg Leu Ser 
    50                  55                  60                  


Ser Met Ala His Ser Val Ile Gly Phe Ile Gln Arg Met Phe Ser Glu 
65                  70                  75                  80  


Gly Ser His Lys Pro Val Val Thr Pro Ala Leu Thr Pro Ala Gln Met 
                85                  90                  95      


Pro Ser Pro Thr Ser Phe Ser Asp Ser Ile Lys Gln Leu Ala Ala Glu 
            100                 105                 110         


Thr Leu Pro Lys Tyr Met Gln Gln Leu Ser Ser Leu Asp Ala Glu Thr 
        115                 120                 125             


Leu Gln Lys Asn His Asp Gln Phe Ala Thr Leu Glu Ser Arg Met Asp 
    130                 135                 140                 


Pro Phe Leu Val Leu Leu His Ser Val Ser Ser Ser Leu Ser Ser Ser 
145                 150                 155                 160 


Glu Leu Thr Glu Leu Lys Phe Leu Cys Leu Gly Arg Val Gly Lys Arg 
                165                 170                 175     


Lys Leu Glu Arg Val Gln Ser Gly Leu Asp Leu Phe Ser Met Leu Leu 
            180                 185                 190         


Glu Gln Asn Asp Leu Glu Pro Gly His Thr Glu Leu Leu Arg Glu Leu 
        195                 200                 205             


Leu Ala Ser Leu Arg Arg His Asp Leu Leu Arg Arg Val Asp Asp Phe 
    210                 215                 220                 


Glu Ala Gly Ala Ala Ala Gly Ala Ala Pro Gly Glu Glu Asp Leu Cys 
225                 230                 235                 240 


Ala Ala Phe Asn Val Ile Cys Asp Asn Val Gly Lys Asp Trp Arg Arg 
                245                 250                 255     


Leu Ala Arg Gln Leu Lys Val Ser Asp Thr Lys Ile Asp Ser Ile Glu 
            260                 265                 270         


Asp Arg Tyr Pro Arg Asn Leu Thr Glu Arg Val Arg Glu Ser Leu Arg 
        275                 280                 285             


Ile Trp Lys Asn Thr Glu Lys Glu Asn Ala Thr Val Ala His Leu Val 
    290                 295                 300                 


Gly Ala Leu Arg Ser Cys Gln Met Asn Leu Val Ala Asp Leu Val Gln 
305                 310                 315                 320 


Glu Val Gln Gln Ala Arg Asp Leu Gln Asn Arg Ser Gly Ala Met Ser 
                325                 330                 335     


Pro Met Ser Trp Asn Ser Asp Ala Ser Thr Ser Glu Ala Ser 
            340                 345                 350 


<210>  29
<211>  308
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YopE1-138 - Bad

<400>  29

Met Lys Ile Ser Ser Phe Ile Ser Thr Ser Leu Pro Leu Pro Ala Ser 
1               5                   10                  15      


Val Ser Gly Ser Ser Ser Val Gly Glu Met Ser Gly Arg Ser Val Ser 
            20                  25                  30          


Gln Gln Lys Ser Asp Gln Tyr Ala Asn Asn Leu Ala Gly Arg Thr Glu 
        35                  40                  45              


Ser Pro Gln Gly Ser Ser Leu Ala Ser Arg Ile Ile Glu Arg Leu Ser 
    50                  55                  60                  


Ser Met Ala His Ser Val Ile Gly Phe Ile Gln Arg Met Phe Ser Glu 
65                  70                  75                  80  


Gly Ser His Lys Pro Val Val Thr Pro Ala Leu Thr Pro Ala Gln Met 
                85                  90                  95      


Pro Ser Pro Thr Ser Phe Ser Asp Ser Ile Lys Gln Leu Ala Ala Glu 
            100                 105                 110         


Thr Leu Pro Lys Tyr Met Gln Gln Leu Ser Ser Leu Asp Ala Glu Thr 
        115                 120                 125             


Leu Gln Lys Asn His Asp Gln Phe Ala Thr Leu Glu Met Phe Gln Ile 
    130                 135                 140                 


Pro Glu Phe Glu Pro Ser Glu Gln Glu Asp Ser Ser Ser Ala Glu Arg 
145                 150                 155                 160 


Gly Leu Gly Pro Ser Pro Ala Gly Asp Gly Pro Ser Gly Ser Gly Lys 
                165                 170                 175     


His His Arg Gln Ala Pro Gly Leu Leu Trp Asp Ala Ser His Gln Gln 
            180                 185                 190         


Glu Gln Pro Thr Ser Ser Ser His His Gly Gly Ala Gly Ala Val Glu 
        195                 200                 205             


Ile Arg Ser Arg His Ser Ser Tyr Pro Ala Gly Thr Glu Asp Asp Glu 
    210                 215                 220                 


Gly Met Gly Glu Glu Pro Ser Pro Phe Arg Gly Arg Ser Arg Ser Ala 
225                 230                 235                 240 


Pro Pro Asn Leu Trp Ala Ala Gln Arg Tyr Gly Arg Glu Leu Arg Arg 
                245                 250                 255     


Met Ser Asp Glu Phe Val Asp Ser Phe Lys Lys Gly Leu Pro Arg Pro 
            260                 265                 270         


Lys Ser Ala Gly Thr Ala Thr Gln Met Arg Gln Ser Ser Ser Trp Thr 
        275                 280                 285             


Arg Val Phe Gln Ser Trp Trp Asp Arg Asn Leu Gly Arg Gly Ser Thr 
    290                 295                 300                 


Ala Pro Ser Gln 
305             


<210>  30
<211>  309
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YopE1-138 - GPCR GNA12

<400>  30

Met Lys Ile Ser Ser Phe Ile Ser Thr Ser Leu Pro Leu Pro Ala Ser 
1               5                   10                  15      


Val Ser Gly Ser Ser Ser Val Gly Glu Met Ser Gly Arg Ser Val Ser 
            20                  25                  30          


Gln Gln Lys Ser Asp Gln Tyr Ala Asn Asn Leu Ala Gly Arg Thr Glu 
        35                  40                  45              


Ser Pro Gln Gly Ser Ser Leu Ala Ser Arg Ile Ile Glu Arg Leu Ser 
    50                  55                  60                  


Ser Met Ala His Ser Val Ile Gly Phe Ile Gln Arg Met Phe Ser Glu 
65                  70                  75                  80  


Gly Ser His Lys Pro Val Val Thr Pro Ala Leu Thr Pro Ala Gln Met 
                85                  90                  95      


Pro Ser Pro Thr Ser Phe Ser Asp Ser Ile Lys Gln Leu Ala Ala Glu 
            100                 105                 110         


Thr Leu Pro Lys Tyr Met Gln Gln Leu Ser Ser Leu Asp Ala Glu Thr 
        115                 120                 125             


Leu Gln Lys Asn His Asp Gln Phe Ala Thr Leu Glu Met Ser Gly Val 
    130                 135                 140                 


Val Gly Pro Met Gln Glu Pro Gly Ala Leu Asp Val Gly Gly Leu Arg 
145                 150                 155                 160 


Ser Gln Arg Gln Lys Trp Phe Gln Cys Phe Asp Gly Ile Thr Ser Ile 
                165                 170                 175     


Leu Phe Met Val Ser Ser Ser Glu Tyr Asp Gln Val Leu Met Glu Asp 
            180                 185                 190         


Arg Arg Thr Asn Arg Leu Val Glu Ser Met Asn Ile Phe Glu Thr Ile 
        195                 200                 205             


Val Asn Asn Lys Leu Phe Phe Asn Val Ser Ile Ile Leu Phe Leu Asn 
    210                 215                 220                 


Lys Met Asp Leu Leu Val Glu Lys Val Lys Thr Val Ser Ile Lys Lys 
225                 230                 235                 240 


His Phe Pro Asp Phe Arg Gly Asp Pro His Arg Leu Glu Asp Val Gln 
                245                 250                 255     


Arg Tyr Leu Val Gln Cys Phe Asp Arg Lys Arg Arg Asn Arg Ser Lys 
            260                 265                 270         


Pro Leu Phe His His Phe Thr Thr Ala Ile Asp Thr Glu Asn Val Arg 
        275                 280                 285             


Phe Val Phe His Ala Val Lys Asp Thr Ile Leu Gln Glu Asn Leu Lys 
    290                 295                 300                 


Asp Ile Met Leu Gln 
305                 


<210>  31
<211>  259
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YopE1-138 - VhH4 nanobody recognizing EGFP

<400>  31

Met Lys Ile Ser Ser Phe Ile Ser Thr Ser Leu Pro Leu Pro Ala Ser 
1               5                   10                  15      


Val Ser Gly Ser Ser Ser Val Gly Glu Met Ser Gly Arg Ser Val Ser 
            20                  25                  30          


Gln Gln Lys Ser Asp Gln Tyr Ala Asn Asn Leu Ala Gly Arg Thr Glu 
        35                  40                  45              


Ser Pro Gln Gly Ser Ser Leu Ala Ser Arg Ile Ile Glu Arg Leu Ser 
    50                  55                  60                  


Ser Met Ala His Ser Val Ile Gly Phe Ile Gln Arg Met Phe Ser Glu 
65                  70                  75                  80  


Gly Ser His Lys Pro Val Val Thr Pro Ala Leu Thr Pro Ala Gln Met 
                85                  90                  95      


Pro Ser Pro Thr Ser Phe Ser Asp Ser Ile Lys Gln Leu Ala Ala Glu 
            100                 105                 110         


Thr Leu Pro Lys Tyr Met Gln Gln Leu Ser Ser Leu Asp Ala Glu Thr 
        115                 120                 125             


Leu Gln Lys Asn His Asp Gln Phe Ala Thr Leu Glu Ser Arg Met Asp 
    130                 135                 140                 


Gln Val Gln Leu Val Glu Ser Gly Gly Ala Leu Val Gln Pro Gly Gly 
145                 150                 155                 160 


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Pro Val Asn Arg Tyr 
                165                 170                 175     


Ser Met Arg Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Trp Val 
            180                 185                 190         


Ala Gly Met Ser Ser Ala Gly Asp Arg Ser Ser Tyr Glu Asp Ser Val 
        195                 200                 205             


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Arg Asn Thr Val Tyr 
    210                 215                 220                 


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
225                 230                 235                 240 


Asn Val Asn Val Gly Phe Glu Tyr Trp Gly Gln Gly Thr Gln Val Thr 
                245                 250                 255     


Val Ser Ser 
            


<210>  32
<211>  458
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YopE1-138 - Slmb1-VhH4

<400>  32

Met Lys Ile Ser Ser Phe Ile Ser Thr Ser Leu Pro Leu Pro Ala Ser 
1               5                   10                  15      


Val Ser Gly Ser Ser Ser Val Gly Glu Met Ser Gly Arg Ser Val Ser 
            20                  25                  30          


Gln Gln Lys Ser Asp Gln Tyr Ala Asn Asn Leu Ala Gly Arg Thr Glu 
        35                  40                  45              


Ser Pro Gln Gly Ser Ser Leu Ala Ser Arg Ile Ile Glu Arg Leu Ser 
    50                  55                  60                  


Ser Met Ala His Ser Val Ile Gly Phe Ile Gln Arg Met Phe Ser Glu 
65                  70                  75                  80  


Gly Ser His Lys Pro Val Val Thr Pro Ala Leu Thr Pro Ala Gln Met 
                85                  90                  95      


Pro Ser Pro Thr Ser Phe Ser Asp Ser Ile Lys Gln Leu Ala Ala Glu 
            100                 105                 110         


Thr Leu Pro Lys Tyr Met Gln Gln Leu Ser Ser Leu Asp Ala Glu Thr 
        115                 120                 125             


Leu Gln Lys Asn His Asp Gln Phe Ala Thr Leu Glu Ser Arg Lys Met 
    130                 135                 140                 


Met Lys Met Glu Thr Asp Lys Ile Met Asp Glu Thr Asn Ser Asn Ala 
145                 150                 155                 160 


Gln Ala Phe Thr Thr Thr Met Leu Tyr Asp Pro Val Arg Lys Lys Asp 
                165                 170                 175     


Ser Ser Pro Thr Tyr Gln Thr Glu Arg Glu Leu Cys Phe Gln Tyr Phe 
            180                 185                 190         


Thr Gln Trp Ser Glu Ser Gly Gln Val Asp Phe Val Glu His Leu Leu 
        195                 200                 205             


Ser Arg Met Cys His Tyr Gln His Gly Gln Ile Asn Ala Tyr Leu Lys 
    210                 215                 220                 


Pro Met Leu Gln Arg Asp Phe Ile Thr Leu Leu Pro Ile Lys Gly Leu 
225                 230                 235                 240 


Asp His Ile Ala Glu Asn Ile Leu Ser Tyr Leu Asp Ala Glu Ser Leu 
                245                 250                 255     


Lys Ser Ser Glu Leu Val Cys Lys Glu Trp Leu Arg Val Ile Ser Glu 
            260                 265                 270         


Gly Met Leu Trp Lys Lys Leu Ile Glu Arg Lys Val Arg Thr Asp Ser 
        275                 280                 285             


Leu Trp Arg Gly Leu Ala Glu Arg Arg Asn Trp Met Gln Tyr Leu Phe 
    290                 295                 300                 


Lys Pro Arg Pro Gly Gln Thr Gln Arg Pro His Ser Phe His Arg Glu 
305                 310                 315                 320 


Leu Phe Pro Lys Ile Met Asn Asp Ile Asp Ser Ile Glu Asn Asn Trp 
                325                 330                 335     


Arg Thr Gly Arg His Met Asp Gln Val Gln Leu Val Glu Ser Gly Gly 
            340                 345                 350         


Ala Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
        355                 360                 365             


Gly Phe Pro Val Asn Arg Tyr Ser Met Arg Trp Tyr Arg Gln Ala Pro 
    370                 375                 380                 


Gly Lys Glu Arg Glu Trp Val Ala Gly Met Ser Ser Ala Gly Asp Arg 
385                 390                 395                 400 


Ser Ser Tyr Glu Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
                405                 410                 415     


Asp Ala Arg Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu 
            420                 425                 430         


Asp Thr Ala Val Tyr Tyr Cys Asn Val Asn Val Gly Phe Glu Tyr Trp 
        435                 440                 445             


Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
    450                 455             


<210>  33
<211>  470
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YopE1-138 - NLS-Slmb1-VhH4

<400>  33

Met Lys Ile Ser Ser Phe Ile Ser Thr Ser Leu Pro Leu Pro Ala Ser 
1               5                   10                  15      


Val Ser Gly Ser Ser Ser Val Gly Glu Met Ser Gly Arg Ser Val Ser 
            20                  25                  30          


Gln Gln Lys Ser Asp Gln Tyr Ala Asn Asn Leu Ala Gly Arg Thr Glu 
        35                  40                  45              


Ser Pro Gln Gly Ser Ser Leu Ala Ser Arg Ile Ile Glu Arg Leu Ser 
    50                  55                  60                  


Ser Met Ala His Ser Val Ile Gly Phe Ile Gln Arg Met Phe Ser Glu 
65                  70                  75                  80  


Gly Ser His Lys Pro Val Val Thr Pro Ala Leu Thr Pro Ala Gln Met 
                85                  90                  95      


Pro Ser Pro Thr Ser Phe Ser Asp Ser Ile Lys Gln Leu Ala Ala Glu 
            100                 105                 110         


Thr Leu Pro Lys Tyr Met Gln Gln Leu Ser Ser Leu Asp Ala Glu Thr 
        115                 120                 125             


Leu Gln Lys Asn His Asp Gln Phe Ala Thr Leu Glu Ser Arg Pro Pro 
    130                 135                 140                 


Lys Lys Lys Arg Lys Val Gln Phe Lys Met Met Lys Met Glu Thr Asp 
145                 150                 155                 160 


Lys Ile Met Asp Glu Thr Asn Ser Asn Ala Gln Ala Phe Thr Thr Thr 
                165                 170                 175     


Met Leu Tyr Asp Pro Val Arg Lys Lys Asp Ser Ser Pro Thr Tyr Gln 
            180                 185                 190         


Thr Glu Arg Glu Leu Cys Phe Gln Tyr Phe Thr Gln Trp Ser Glu Ser 
        195                 200                 205             


Gly Gln Val Asp Phe Val Glu His Leu Leu Ser Arg Met Cys His Tyr 
    210                 215                 220                 


Gln His Gly Gln Ile Asn Ala Tyr Leu Lys Pro Met Leu Gln Arg Asp 
225                 230                 235                 240 


Phe Ile Thr Leu Leu Pro Ile Lys Gly Leu Asp His Ile Ala Glu Asn 
                245                 250                 255     


Ile Leu Ser Tyr Leu Asp Ala Glu Ser Leu Lys Ser Ser Glu Leu Val 
            260                 265                 270         


Cys Lys Glu Trp Leu Arg Val Ile Ser Glu Gly Met Leu Trp Lys Lys 
        275                 280                 285             


Leu Ile Glu Arg Lys Val Arg Thr Asp Ser Leu Trp Arg Gly Leu Ala 
    290                 295                 300                 


Glu Arg Arg Asn Trp Met Gln Tyr Leu Phe Lys Pro Arg Pro Gly Gln 
305                 310                 315                 320 


Thr Gln Arg Pro His Ser Phe His Arg Glu Leu Phe Pro Lys Ile Met 
                325                 330                 335     


Asn Asp Ile Asp Ser Ile Glu Asn Asn Trp Arg Thr Gly Arg His Leu 
            340                 345                 350         


Glu Met Asp Gln Val Gln Leu Val Glu Ser Gly Gly Ala Leu Val Gln 
        355                 360                 365             


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Pro Val 
    370                 375                 380                 


Asn Arg Tyr Ser Met Arg Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg 
385                 390                 395                 400 


Glu Trp Val Ala Gly Met Ser Ser Ala Gly Asp Arg Ser Ser Tyr Glu 
                405                 410                 415     


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Arg Asn 
            420                 425                 430         


Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val 
        435                 440                 445             


Tyr Tyr Cys Asn Val Asn Val Gly Phe Glu Tyr Trp Gly Gln Gly Thr 
    450                 455                 460                 


Gln Val Thr Val Ser Ser 
465                 470 


<210>  34
<211>  466
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YopE1-138 - Slmb1-VhH4-NLS

<400>  34

Met Lys Ile Ser Ser Phe Ile Ser Thr Ser Leu Pro Leu Pro Ala Ser 
1               5                   10                  15      


Val Ser Gly Ser Ser Ser Val Gly Glu Met Ser Gly Arg Ser Val Ser 
            20                  25                  30          


Gln Gln Lys Ser Asp Gln Tyr Ala Asn Asn Leu Ala Gly Arg Thr Glu 
        35                  40                  45              


Ser Pro Gln Gly Ser Ser Leu Ala Ser Arg Ile Ile Glu Arg Leu Ser 
    50                  55                  60                  


Ser Met Ala His Ser Val Ile Gly Phe Ile Gln Arg Met Phe Ser Glu 
65                  70                  75                  80  


Gly Ser His Lys Pro Val Val Thr Pro Ala Leu Thr Pro Ala Gln Met 
                85                  90                  95      


Pro Ser Pro Thr Ser Phe Ser Asp Ser Ile Lys Gln Leu Ala Ala Glu 
            100                 105                 110         


Thr Leu Pro Lys Tyr Met Gln Gln Leu Ser Ser Leu Asp Ala Glu Thr 
        115                 120                 125             


Leu Gln Lys Asn His Asp Gln Phe Ala Thr Leu Glu Ser Arg Lys Met 
    130                 135                 140                 


Met Lys Met Glu Thr Asp Lys Ile Met Asp Glu Thr Asn Ser Asn Ala 
145                 150                 155                 160 


Gln Ala Phe Thr Thr Thr Met Leu Tyr Asp Pro Val Arg Lys Lys Asp 
                165                 170                 175     


Ser Ser Pro Thr Tyr Gln Thr Glu Arg Glu Leu Cys Phe Gln Tyr Phe 
            180                 185                 190         


Thr Gln Trp Ser Glu Ser Gly Gln Val Asp Phe Val Glu His Leu Leu 
        195                 200                 205             


Ser Arg Met Cys His Tyr Gln His Gly Gln Ile Asn Ala Tyr Leu Lys 
    210                 215                 220                 


Pro Met Leu Gln Arg Asp Phe Ile Thr Leu Leu Pro Ile Lys Gly Leu 
225                 230                 235                 240 


Asp His Ile Ala Glu Asn Ile Leu Ser Tyr Leu Asp Ala Glu Ser Leu 
                245                 250                 255     


Lys Ser Ser Glu Leu Val Cys Lys Glu Trp Leu Arg Val Ile Ser Glu 
            260                 265                 270         


Gly Met Leu Trp Lys Lys Leu Ile Glu Arg Lys Val Arg Thr Asp Ser 
        275                 280                 285             


Leu Trp Arg Gly Leu Ala Glu Arg Arg Asn Trp Met Gln Tyr Leu Phe 
    290                 295                 300                 


Lys Pro Arg Pro Gly Gln Thr Gln Arg Pro His Ser Phe His Arg Glu 
305                 310                 315                 320 


Leu Phe Pro Lys Ile Met Asn Asp Ile Asp Ser Ile Glu Asn Asn Trp 
                325                 330                 335     


Arg Thr Gly Arg His Met Asp Gln Val Gln Leu Val Glu Ser Gly Gly 
            340                 345                 350         


Ala Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
        355                 360                 365             


Gly Phe Pro Val Asn Arg Tyr Ser Met Arg Trp Tyr Arg Gln Ala Pro 
    370                 375                 380                 


Gly Lys Glu Arg Glu Trp Val Ala Gly Met Ser Ser Ala Gly Asp Arg 
385                 390                 395                 400 


Ser Ser Tyr Glu Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
                405                 410                 415     


Asp Ala Arg Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu 
            420                 425                 430         


Asp Thr Ala Val Tyr Tyr Cys Asn Val Asn Val Gly Phe Glu Tyr Trp 
        435                 440                 445             


Gly Gln Gly Thr Gln Val Thr Val Ser Ser Pro Pro Lys Lys Lys Arg 
    450                 455                 460                 


Lys Val 
465     


<210>  35
<211>  246
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YopE1-138 - Akt PH-domain

<400>  35

Met Lys Ile Ser Ser Phe Ile Ser Thr Ser Leu Pro Leu Pro Ala Ser 
1               5                   10                  15      


Val Ser Gly Ser Ser Ser Val Gly Glu Met Ser Gly Arg Ser Val Ser 
            20                  25                  30          


Gln Gln Lys Ser Asp Gln Tyr Ala Asn Asn Leu Ala Gly Arg Thr Glu 
        35                  40                  45              


Ser Pro Gln Gly Ser Ser Leu Ala Ser Arg Ile Ile Glu Arg Leu Ser 
    50                  55                  60                  


Ser Met Ala His Ser Val Ile Gly Phe Ile Gln Arg Met Phe Ser Glu 
65                  70                  75                  80  


Gly Ser His Lys Pro Val Val Thr Pro Ala Leu Thr Pro Ala Gln Met 
                85                  90                  95      


Pro Ser Pro Thr Ser Phe Ser Asp Ser Ile Lys Gln Leu Ala Ala Glu 
            100                 105                 110         


Thr Leu Pro Lys Tyr Met Gln Gln Leu Ser Ser Leu Asp Ala Glu Thr 
        115                 120                 125             


Leu Gln Lys Asn His Asp Gln Phe Ala Thr Leu Glu Ser Arg Ala Ile 
    130                 135                 140                 


Val Lys Glu Gly Trp Leu His Lys Arg Gly Glu Tyr Ile Lys Thr Trp 
145                 150                 155                 160 


Arg Pro Arg Tyr Phe Leu Leu Lys Asn Asp Gly Thr Phe Ile Gly Tyr 
                165                 170                 175     


Lys Glu Arg Pro Gln Asp Val Asp Gln Arg Glu Ala Pro Leu Asn Asn 
            180                 185                 190         


Phe Ser Val Ala Gln Cys Gln Leu Met Lys Thr Glu Arg Pro Arg Pro 
        195                 200                 205             


Asn Thr Phe Ile Ile Arg Cys Leu Gln Trp Thr Thr Val Ile Glu Arg 
    210                 215                 220                 


Thr Phe His Val Glu Thr Pro Glu Glu Arg Glu Glu Trp Thr Thr Ala 
225                 230                 235                 240 


Ile Gln Thr Val Ala Asp 
                245     


<210>  36
<211>  465
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YopE1-138 - ET1

<400>  36

Met Lys Ile Ser Ser Phe Ile Ser Thr Ser Leu Pro Leu Pro Ala Ser 
1               5                   10                  15      


Val Ser Gly Ser Ser Ser Val Gly Glu Met Ser Gly Arg Ser Val Ser 
            20                  25                  30          


Gln Gln Lys Ser Asp Gln Tyr Ala Asn Asn Leu Ala Gly Arg Thr Glu 
        35                  40                  45              


Ser Pro Gln Gly Ser Ser Leu Ala Ser Arg Ile Ile Glu Arg Leu Ser 
    50                  55                  60                  


Ser Met Ala His Ser Val Ile Gly Phe Ile Gln Arg Met Phe Ser Glu 
65                  70                  75                  80  


Gly Ser His Lys Pro Val Val Thr Pro Ala Leu Thr Pro Ala Gln Met 
                85                  90                  95      


Pro Ser Pro Thr Ser Phe Ser Asp Ser Ile Lys Gln Leu Ala Ala Glu 
            100                 105                 110         


Thr Leu Pro Lys Tyr Met Gln Gln Leu Ser Ser Leu Asp Ala Glu Thr 
        115                 120                 125             


Leu Gln Lys Asn His Asp Gln Phe Ala Thr Leu Glu Ser Arg Met Pro 
    130                 135                 140                 


Arg Pro Lys Leu Lys Ser Asp Asp Glu Val Leu Glu Ala Ala Thr Val 
145                 150                 155                 160 


Val Leu Lys Arg Cys Gly Pro Ile Glu Phe Thr Leu Ser Gly Val Ala 
                165                 170                 175     


Lys Glu Val Gly Leu Ser Arg Ala Ala Leu Ile Gln Arg Phe Thr Asn 
            180                 185                 190         


Arg Asp Thr Leu Leu Val Arg Met Met Glu Arg Gly Val Glu Gln Val 
        195                 200                 205             


Arg His Tyr Leu Asn Ala Ile Pro Ile Gly Ala Gly Pro Gln Gly Leu 
    210                 215                 220                 


Trp Glu Phe Leu Gln Val Leu Val Arg Ser Met Asn Thr Arg Asn Asp 
225                 230                 235                 240 


Phe Ser Val Asn Tyr Leu Ile Ser Trp Tyr Glu Leu Gln Val Pro Glu 
                245                 250                 255     


Leu Arg Thr Leu Ala Ile Gln Arg Asn Arg Ala Val Val Glu Gly Ile 
            260                 265                 270         


Arg Lys Arg Leu Pro Pro Gly Ala Pro Ala Ala Ala Glu Leu Leu Leu 
        275                 280                 285             


His Ser Val Ile Ala Gly Ala Thr Met Gln Trp Ala Val Asp Pro Asp 
    290                 295                 300                 


Gly Glu Leu Ala Asp His Val Leu Ala Gln Ile Ala Ala Ile Leu Cys 
305                 310                 315                 320 


Leu Met Phe Pro Glu His Asp Asp Phe Gln Leu Leu Gln Ala His Ala 
                325                 330                 335     


Ser Ala Tyr Ser Arg Ala Arg Thr Lys Asn Asn Tyr Gly Ser Thr Ile 
            340                 345                 350         


Glu Gly Leu Leu Asp Leu Pro Asp Asp Asp Ala Pro Glu Glu Ala Gly 
        355                 360                 365             


Leu Ala Ala Pro Arg Leu Ser Phe Leu Pro Ala Gly His Thr Arg Arg 
    370                 375                 380                 


Leu Ser Thr Ala Pro Pro Thr Asp Val Ser Leu Gly Asp Glu Leu His 
385                 390                 395                 400 


Leu Asp Gly Glu Asp Val Ala Met Ala His Ala Asp Ala Leu Asp Asp 
                405                 410                 415     


Phe Asp Leu Asp Met Leu Gly Asp Gly Asp Ser Pro Gly Pro Gly Phe 
            420                 425                 430         


Thr Pro His Asp Ser Ala Pro Tyr Gly Ala Leu Asp Met Ala Asp Phe 
        435                 440                 445             


Glu Phe Glu Gln Met Phe Thr Asp Ala Leu Gly Ile Asp Glu Tyr Gly 
    450                 455                 460                 


Gly 
465 


<210>  37
<211>  381
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YopE1-138 - EGFP

<400>  37

Met Lys Ile Ser Ser Phe Ile Ser Thr Ser Leu Pro Leu Pro Ala Ser 
1               5                   10                  15      


Val Ser Gly Ser Ser Ser Val Gly Glu Met Ser Gly Arg Ser Val Ser 
            20                  25                  30          


Gln Gln Lys Ser Asp Gln Tyr Ala Asn Asn Leu Ala Gly Arg Thr Glu 
        35                  40                  45              


Ser Pro Gln Gly Ser Ser Leu Ala Ser Arg Ile Ile Glu Arg Leu Ser 
    50                  55                  60                  


Ser Met Ala His Ser Val Ile Gly Phe Ile Gln Arg Met Phe Ser Glu 
65                  70                  75                  80  


Gly Ser His Lys Pro Val Val Thr Pro Ala Leu Thr Pro Ala Gln Met 
                85                  90                  95      


Pro Ser Pro Thr Ser Phe Ser Asp Ser Ile Lys Gln Leu Ala Ala Glu 
            100                 105                 110         


Thr Leu Pro Lys Tyr Met Gln Gln Leu Ser Ser Leu Asp Ala Glu Thr 
        115                 120                 125             


Leu Gln Lys Asn His Asp Gln Phe Ala Thr Leu Glu Ser Arg Met Val 
    130                 135                 140                 


Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu 
145                 150                 155                 160 


Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly Glu Gly 
                165                 170                 175     


Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr 
            180                 185                 190         


Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Leu Thr 
        195                 200                 205             


Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys Gln His 
    210                 215                 220                 


Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr 
225                 230                 235                 240 


Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys 
                245                 250                 255     


Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp 
            260                 265                 270         


Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn Tyr 
        275                 280                 285             


Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys Gln Lys Asn Gly Ile 
    290                 295                 300                 


Lys Val Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser Val Gln 
305                 310                 315                 320 


Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val 
                325                 330                 335     


Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu Ser Lys 
            340                 345                 350         


Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe Val Thr 
        355                 360                 365             


Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys 
    370                 375                 380     


<210>  38
<211>  402
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YopE1-138 - 2xTEVsite - NLS - EGFP

<400>  38

Met Lys Ile Ser Ser Phe Ile Ser Thr Ser Leu Pro Leu Pro Ala Ser 
1               5                   10                  15      


Val Ser Gly Ser Ser Ser Val Gly Glu Met Ser Gly Arg Ser Val Ser 
            20                  25                  30          


Gln Gln Lys Ser Asp Gln Tyr Ala Asn Asn Leu Ala Gly Arg Thr Glu 
        35                  40                  45              


Ser Pro Gln Gly Ser Ser Leu Ala Ser Arg Ile Ile Glu Arg Leu Ser 
    50                  55                  60                  


Ser Met Ala His Ser Val Ile Gly Phe Ile Gln Arg Met Phe Ser Glu 
65                  70                  75                  80  


Gly Ser His Lys Pro Val Val Thr Pro Ala Leu Thr Pro Ala Gln Met 
                85                  90                  95      


Pro Ser Pro Thr Ser Phe Ser Asp Ser Ile Lys Gln Leu Ala Ala Glu 
            100                 105                 110         


Thr Leu Pro Lys Tyr Met Gln Gln Leu Ser Ser Leu Asp Ala Glu Thr 
        115                 120                 125             


Leu Gln Lys Asn His Asp Gln Phe Ala Thr Leu Glu Ser Arg Glu Asn 
    130                 135                 140                 


Leu Tyr Phe Gln Ser Glu Asn Leu Tyr Phe Gln Ser Pro Pro Lys Lys 
145                 150                 155                 160 


Lys Arg Lys Val Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val 
                165                 170                 175     


Pro Ile Leu Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser 
            180                 185                 190         


Val Ser Gly Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu 
        195                 200                 205             


Lys Phe Ile Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu 
    210                 215                 220                 


Val Thr Thr Leu Thr Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp 
225                 230                 235                 240 


His Met Lys Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr 
                245                 250                 255     


Val Gln Glu Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr 
            260                 265                 270         


Arg Ala Glu Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu 
        275                 280                 285             


Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys 
    290                 295                 300                 


Leu Glu Tyr Asn Tyr Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys 
305                 310                 315                 320 


Gln Lys Asn Gly Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile Glu 
                325                 330                 335     


Asp Gly Ser Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile 
            340                 345                 350         


Gly Asp Gly Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln 
        355                 360                 365             


Ser Ala Leu Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu 
    370                 375                 380                 


Leu Glu Phe Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu 
385                 390                 395                 400 


Tyr Lys 
        


<210>  39
<211>  402
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YopE1-138 - 2xTEVsite - EGFP - NLS

<400>  39

Met Lys Ile Ser Ser Phe Ile Ser Thr Ser Leu Pro Leu Pro Ala Ser 
1               5                   10                  15      


Val Ser Gly Ser Ser Ser Val Gly Glu Met Ser Gly Arg Ser Val Ser 
            20                  25                  30          


Gln Gln Lys Ser Asp Gln Tyr Ala Asn Asn Leu Ala Gly Arg Thr Glu 
        35                  40                  45              


Ser Pro Gln Gly Ser Ser Leu Ala Ser Arg Ile Ile Glu Arg Leu Ser 
    50                  55                  60                  


Ser Met Ala His Ser Val Ile Gly Phe Ile Gln Arg Met Phe Ser Glu 
65                  70                  75                  80  


Gly Ser His Lys Pro Val Val Thr Pro Ala Leu Thr Pro Ala Gln Met 
                85                  90                  95      


Pro Ser Pro Thr Ser Phe Ser Asp Ser Ile Lys Gln Leu Ala Ala Glu 
            100                 105                 110         


Thr Leu Pro Lys Tyr Met Gln Gln Leu Ser Ser Leu Asp Ala Glu Thr 
        115                 120                 125             


Leu Gln Lys Asn His Asp Gln Phe Ala Thr Leu Glu Ser Arg Glu Asn 
    130                 135                 140                 


Leu Tyr Phe Gln Ser Glu Asn Leu Tyr Phe Gln Ser Val Ser Lys Gly 
145                 150                 155                 160 


Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly 
                165                 170                 175     


Asp Val Asn Gly His Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp 
            180                 185                 190         


Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys 
        195                 200                 205             


Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Leu Thr Tyr Gly Val 
    210                 215                 220                 


Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe 
225                 230                 235                 240 


Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Phe 
                245                 250                 255     


Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly 
            260                 265                 270         


Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu 
        275                 280                 285             


Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn Tyr Asn Ser His 
    290                 295                 300                 


Asn Val Tyr Ile Met Ala Asp Lys Gln Lys Asn Gly Ile Lys Val Asn 
305                 310                 315                 320 


Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser Val Gln Leu Ala Asp 
                325                 330                 335     


His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro 
            340                 345                 350         


Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu Ser Lys Asp Pro Asn 
        355                 360                 365             


Glu Lys Arg Asp His Met Val Leu Leu Glu Phe Val Thr Ala Ala Gly 
    370                 375                 380                 


Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys Pro Pro Lys Lys Lys Arg 
385                 390                 395                 400 


Lys Val 
        


<210>  40
<211>  324
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YopE1-138 - 2x TEVsite - INK4C

<400>  40

Met Lys Ile Ser Ser Phe Ile Ser Thr Ser Leu Pro Leu Pro Ala Ser 
1               5                   10                  15      


Val Ser Gly Ser Ser Ser Val Gly Glu Met Ser Gly Arg Ser Val Ser 
            20                  25                  30          


Gln Gln Lys Ser Asp Gln Tyr Ala Asn Asn Leu Ala Gly Arg Thr Glu 
        35                  40                  45              


Ser Pro Gln Gly Ser Ser Leu Ala Ser Arg Ile Ile Glu Arg Leu Ser 
    50                  55                  60                  


Ser Met Ala His Ser Val Ile Gly Phe Ile Gln Arg Met Phe Ser Glu 
65                  70                  75                  80  


Gly Ser His Lys Pro Val Val Thr Pro Ala Leu Thr Pro Ala Gln Met 
                85                  90                  95      


Pro Ser Pro Thr Ser Phe Ser Asp Ser Ile Lys Gln Leu Ala Ala Glu 
            100                 105                 110         


Thr Leu Pro Lys Tyr Met Gln Gln Leu Ser Ser Leu Asp Ala Glu Thr 
        115                 120                 125             


Leu Gln Lys Asn His Asp Gln Phe Ala Thr Leu Glu Ser Arg Glu Asn 
    130                 135                 140                 


Leu Tyr Phe Gln Ser Glu Asn Leu Tyr Phe Gln Ser Met Ala Glu Pro 
145                 150                 155                 160 


Trp Gly Asn Glu Leu Ala Ser Ala Ala Ala Arg Gly Asp Leu Glu Gln 
                165                 170                 175     


Leu Thr Ser Leu Leu Gln Asn Asn Val Asn Val Asn Ala Gln Asn Gly 
            180                 185                 190         


Phe Gly Arg Thr Ala Leu Gln Val Met Lys Leu Gly Asn Pro Glu Ile 
        195                 200                 205             


Ala Arg Arg Leu Leu Leu Arg Gly Ala Asn Pro Asp Leu Lys Asp Arg 
    210                 215                 220                 


Thr Gly Phe Ala Val Ile His Asp Ala Ala Arg Ala Gly Phe Leu Asp 
225                 230                 235                 240 


Thr Leu Gln Ala Leu Pro Glu Phe Gln Ala Asp Val Asn Ile Glu Asp 
                245                 250                 255     


Asn Glu Gly Asn Leu Pro Leu His Leu Ala Ala Lys Glu Gly His Leu 
            260                 265                 270         


Arg Val Val Glu Phe Leu Val Lys His Thr Ala Ser Asn Val Gly His 
        275                 280                 285             


Arg Asn His Lys Gly Asp Thr Ala Cys Asp Leu Ala Arg Leu Tyr Gly 
    290                 295                 300                 


Arg Asn Glu Val Val Ser Leu Met Gln Ala Asn Gly Ala Gly Gly Ala 
305                 310                 315                 320 


Thr Asn Leu Gln 
                


<210>  41
<211>  479
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YopE1-138 - 2x TEVsite - ET1

<400>  41

Met Lys Ile Ser Ser Phe Ile Ser Thr Ser Leu Pro Leu Pro Ala Ser 
1               5                   10                  15      


Val Ser Gly Ser Ser Ser Val Gly Glu Met Ser Gly Arg Ser Val Ser 
            20                  25                  30          


Gln Gln Lys Ser Asp Gln Tyr Ala Asn Asn Leu Ala Gly Arg Thr Glu 
        35                  40                  45              


Ser Pro Gln Gly Ser Ser Leu Ala Ser Arg Ile Ile Glu Arg Leu Ser 
    50                  55                  60                  


Ser Met Ala His Ser Val Ile Gly Phe Ile Gln Arg Met Phe Ser Glu 
65                  70                  75                  80  


Gly Ser His Lys Pro Val Val Thr Pro Ala Leu Thr Pro Ala Gln Met 
                85                  90                  95      


Pro Ser Pro Thr Ser Phe Ser Asp Ser Ile Lys Gln Leu Ala Ala Glu 
            100                 105                 110         


Thr Leu Pro Lys Tyr Met Gln Gln Leu Ser Ser Leu Asp Ala Glu Thr 
        115                 120                 125             


Leu Gln Lys Asn His Asp Gln Phe Ala Thr Leu Glu Ser Arg Glu Asn 
    130                 135                 140                 


Leu Tyr Phe Gln Ser Glu Asn Leu Tyr Phe Gln Ser Met Pro Arg Pro 
145                 150                 155                 160 


Lys Leu Lys Ser Asp Asp Glu Val Leu Glu Ala Ala Thr Val Val Leu 
                165                 170                 175     


Lys Arg Cys Gly Pro Ile Glu Phe Thr Leu Ser Gly Val Ala Lys Glu 
            180                 185                 190         


Val Gly Leu Ser Arg Ala Ala Leu Ile Gln Arg Phe Thr Asn Arg Asp 
        195                 200                 205             


Thr Leu Leu Val Arg Met Met Glu Arg Gly Val Glu Gln Val Arg His 
    210                 215                 220                 


Tyr Leu Asn Ala Ile Pro Ile Gly Ala Gly Pro Gln Gly Leu Trp Glu 
225                 230                 235                 240 


Phe Leu Gln Val Leu Val Arg Ser Met Asn Thr Arg Asn Asp Phe Ser 
                245                 250                 255     


Val Asn Tyr Leu Ile Ser Trp Tyr Glu Leu Gln Val Pro Glu Leu Arg 
            260                 265                 270         


Thr Leu Ala Ile Gln Arg Asn Arg Ala Val Val Glu Gly Ile Arg Lys 
        275                 280                 285             


Arg Leu Pro Pro Gly Ala Pro Ala Ala Ala Glu Leu Leu Leu His Ser 
    290                 295                 300                 


Val Ile Ala Gly Ala Thr Met Gln Trp Ala Val Asp Pro Asp Gly Glu 
305                 310                 315                 320 


Leu Ala Asp His Val Leu Ala Gln Ile Ala Ala Ile Leu Cys Leu Met 
                325                 330                 335     


Phe Pro Glu His Asp Asp Phe Gln Leu Leu Gln Ala His Ala Ser Ala 
            340                 345                 350         


Tyr Ser Arg Ala Arg Thr Lys Asn Asn Tyr Gly Ser Thr Ile Glu Gly 
        355                 360                 365             


Leu Leu Asp Leu Pro Asp Asp Asp Ala Pro Glu Glu Ala Gly Leu Ala 
    370                 375                 380                 


Ala Pro Arg Leu Ser Phe Leu Pro Ala Gly His Thr Arg Arg Leu Ser 
385                 390                 395                 400 


Thr Ala Pro Pro Thr Asp Val Ser Leu Gly Asp Glu Leu His Leu Asp 
                405                 410                 415     


Gly Glu Asp Val Ala Met Ala His Ala Asp Ala Leu Asp Asp Phe Asp 
            420                 425                 430         


Leu Asp Met Leu Gly Asp Gly Asp Ser Pro Gly Pro Gly Phe Thr Pro 
        435                 440                 445             


His Asp Ser Ala Pro Tyr Gly Ala Leu Asp Met Ala Asp Phe Glu Phe 
    450                 455                 460                 


Glu Gln Met Phe Thr Asp Ala Leu Gly Ile Asp Glu Tyr Gly Gly 
465                 470                 475                 


<210>  42
<211>  380
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YopE1-138 - TEV protease S219V

<400>  42

Met Lys Ile Ser Ser Phe Ile Ser Thr Ser Leu Pro Leu Pro Ala Ser 
1               5                   10                  15      


Val Ser Gly Ser Ser Ser Val Gly Glu Met Ser Gly Arg Ser Val Ser 
            20                  25                  30          


Gln Gln Lys Ser Asp Gln Tyr Ala Asn Asn Leu Ala Gly Arg Thr Glu 
        35                  40                  45              


Ser Pro Gln Gly Ser Ser Leu Ala Ser Arg Ile Ile Glu Arg Leu Ser 
    50                  55                  60                  


Ser Met Ala His Ser Val Ile Gly Phe Ile Gln Arg Met Phe Ser Glu 
65                  70                  75                  80  


Gly Ser His Lys Pro Val Val Thr Pro Ala Leu Thr Pro Ala Gln Met 
                85                  90                  95      


Pro Ser Pro Thr Ser Phe Ser Asp Ser Ile Lys Gln Leu Ala Ala Glu 
            100                 105                 110         


Thr Leu Pro Lys Tyr Met Gln Gln Leu Ser Ser Leu Asp Ala Glu Thr 
        115                 120                 125             


Leu Gln Lys Asn His Asp Gln Phe Ala Thr Leu Glu Glu Ser Leu Phe 
    130                 135                 140                 


Lys Gly Pro Arg Asp Tyr Asn Pro Ile Ser Ser Thr Ile Cys His Leu 
145                 150                 155                 160 


Thr Asn Glu Ser Asp Gly His Thr Thr Ser Leu Tyr Gly Ile Gly Phe 
                165                 170                 175     


Gly Pro Phe Ile Ile Thr Asn Lys His Leu Phe Arg Arg Asn Asn Gly 
            180                 185                 190         


Thr Leu Leu Val Gln Ser Leu His Gly Val Phe Lys Val Lys Asn Thr 
        195                 200                 205             


Thr Thr Leu Gln Gln His Leu Ile Asp Gly Arg Asp Met Ile Ile Ile 
    210                 215                 220                 


Arg Met Pro Lys Asp Phe Pro Pro Phe Pro Gln Lys Leu Lys Phe Arg 
225                 230                 235                 240 


Glu Pro Gln Arg Glu Glu Arg Ile Cys Leu Val Thr Thr Asn Phe Gln 
                245                 250                 255     


Thr Lys Ser Met Ser Ser Met Val Ser Asp Thr Ser Cys Thr Phe Pro 
            260                 265                 270         


Ser Ser Asp Gly Ile Phe Trp Lys His Trp Ile Gln Thr Lys Asp Gly 
        275                 280                 285             


Gln Cys Gly Ser Pro Leu Val Ser Thr Arg Asp Gly Phe Ile Val Gly 
    290                 295                 300                 


Ile His Ser Ala Ser Asn Phe Thr Asn Thr Asn Asn Tyr Phe Thr Ser 
305                 310                 315                 320 


Val Pro Lys Asn Phe Met Glu Leu Leu Thr Asn Gln Glu Ala Gln Gln 
                325                 330                 335     


Trp Val Ser Gly Trp Arg Leu Asn Ala Asp Ser Val Leu Trp Gly Gly 
            340                 345                 350         


His Lys Val Phe Met Val Lys Pro Glu Glu Pro Phe Gln Pro Val Lys 
        355                 360                 365             


Glu Ala Thr Gln Leu Met Asn Arg Arg Arg Arg Arg 
    370                 375                 380 


<210>  43
<211>  332
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YopE1-138 - 2x TEVsite - Flag - INK4C

<400>  43

Met Lys Ile Ser Ser Phe Ile Ser Thr Ser Leu Pro Leu Pro Ala Ser 
1               5                   10                  15      


Val Ser Gly Ser Ser Ser Val Gly Glu Met Ser Gly Arg Ser Val Ser 
            20                  25                  30          


Gln Gln Lys Ser Asp Gln Tyr Ala Asn Asn Leu Ala Gly Arg Thr Glu 
        35                  40                  45              


Ser Pro Gln Gly Ser Ser Leu Ala Ser Arg Ile Ile Glu Arg Leu Ser 
    50                  55                  60                  


Ser Met Ala His Ser Val Ile Gly Phe Ile Gln Arg Met Phe Ser Glu 
65                  70                  75                  80  


Gly Ser His Lys Pro Val Val Thr Pro Ala Leu Thr Pro Ala Gln Met 
                85                  90                  95      


Pro Ser Pro Thr Ser Phe Ser Asp Ser Ile Lys Gln Leu Ala Ala Glu 
            100                 105                 110         


Thr Leu Pro Lys Tyr Met Gln Gln Leu Ser Ser Leu Asp Ala Glu Thr 
        115                 120                 125             


Leu Gln Lys Asn His Asp Gln Phe Ala Thr Leu Glu Ser Arg Glu Asn 
    130                 135                 140                 


Leu Tyr Phe Gln Ser Glu Asn Leu Tyr Phe Gln Ser Asp Tyr Lys Asp 
145                 150                 155                 160 


Asp Asp Asp Lys Met Ala Glu Pro Trp Gly Asn Glu Leu Ala Ser Ala 
                165                 170                 175     


Ala Ala Arg Gly Asp Leu Glu Gln Leu Thr Ser Leu Leu Gln Asn Asn 
            180                 185                 190         


Val Asn Val Asn Ala Gln Asn Gly Phe Gly Arg Thr Ala Leu Gln Val 
        195                 200                 205             


Met Lys Leu Gly Asn Pro Glu Ile Ala Arg Arg Leu Leu Leu Arg Gly 
    210                 215                 220                 


Ala Asn Pro Asp Leu Lys Asp Arg Thr Gly Phe Ala Val Ile His Asp 
225                 230                 235                 240 


Ala Ala Arg Ala Gly Phe Leu Asp Thr Leu Gln Ala Leu Pro Glu Phe 
                245                 250                 255     


Gln Ala Asp Val Asn Ile Glu Asp Asn Glu Gly Asn Leu Pro Leu His 
            260                 265                 270         


Leu Ala Ala Lys Glu Gly His Leu Arg Val Val Glu Phe Leu Val Lys 
        275                 280                 285             


His Thr Ala Ser Asn Val Gly His Arg Asn His Lys Gly Asp Thr Ala 
    290                 295                 300                 


Cys Asp Leu Ala Arg Leu Tyr Gly Arg Asn Glu Val Val Ser Leu Met 
305                 310                 315                 320 


Gln Ala Asn Gly Ala Gly Gly Ala Thr Asn Leu Gln 
                325                 330         


<210>  44
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer No. : Si_285

<400>  44
cataccatgg gagtgagcaa gggcgag                                           27


<210>  45
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer No. : Si_286

<400>  45
ggaagatctt tacttgtaca gctcgtccat                                        30


<210>  46
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer No. : Si_287

<400>  46
cggggtacct caactaaatg accgtggtg                                         29


<210>  47
<211>  43
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer No. : Si_288

<400>  47
gttaaagctt ttcgaatcta gactcgagcg tggcgaactg gtc                         43


<210>  48
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer No. : Si_292

<400>  48
cagtctcgag caaattctaa acaaaatact tccac                                  35


<210>  49
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer No. : Si_293

<400>  49
cagtttcgaa ttaatttgta ttgctttgac gg                                     32


<210>  50
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer No. : Si_296

<400>  50
cagtctcgag actaacataa cactatccac ccag                                   34


<210>  51
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer No. : Si_297

<400>  51
gttaaagctt tcaggaggca ttctgaag                                          28


<210>  52
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer No. : Si_299

<400>  52
cagtctcgag caggccatca agtgtgtg                                          28


<210>  53
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer No. : Si_300

<400>  53
cagtttcgaa tcattttctc ttcctcttct tca                                    33


<210>  54
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer No. : Si_301

<400>  54
cagtctcgag gctgccatcc ggaa                                              24


<210>  55
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer No. : Si_302

<400>  55
cagtttcgaa tcacaagaca aggcaccc                                          28


<210>  56
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer No. : Si_306

<400>  56
gttaaagctt ggaggcattc tgaagatact tatt                                   34


<210>  57
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer No. : Si_307

<400>  57
cagtctcgag caaatacaga gcttctatca ctcag                                  35


<210>  58
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer No. : Si_308

<400>  58
gttaaagctt tcaagatgtg attaatgaag aaatg                                  35


<210>  59
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer No. : Si_317

<400>  59
cagtttcgaa cccataaaaa agccctgtc                                         29


<210>  60
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer No. : Si_318

<400>  60
gttaaagctt ctactctatc atcaaacgat aaaatgg                                37


<210>  61
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer No. : Si_324

<400>  61
cagtctcgag ttcactcaag aaacgcaaa                                         29


<210>  62
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer No. : Si_339

<400>  62
cagtttcgaa ttttctcttc ctcttcttca cg                                     32


<210>  63
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer No. : Si_341

<400>  63
cgtatctaga aaaatgatga aaatggagac tg                                     32


<210>  64
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer No. : Si_342

<400>  64
gttaaagctt ttagctggag acggtgac                                          28


<210>  65
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer No. : Si_346

<400>  65
cagtctcgag ttccagatcc cagagtttg                                         29


<210>  66
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer No. : Si_347

<400>  66
gttaaagctt tcactgggag gggg                                              24


<210>  67
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer No. : Si_351

<400>  67
cagtctcgag ctcgagttat ctactcatag aaactacttt tgcag                       45


<210>  68
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer No. : Si_352

<400>  68
cgcggatcct cagtgtctct gcggcatta                                         29


<210>  69
<211>  43
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer No. : Si_353

<400>  69
catttattcc tcctagttag tcacagcaac tgctgctcct ttc                         43


<210>  70
<211>  43
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer No. : Si_354

<400>  70
gaaaggagca gcagttgctg tgactaacta ggaggaataa atg                         43


<210>  71
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer No. : Si_355

<400>  71
cgattcacgg attgctttct cattattccc tccaggtact a                           41


<210>  72
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer No. : Si_356

<400>  72
tagtacctgg agggaataat gagaaagcaa tccgtgaatc g                           41


<210>  73
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer No. : Si_357

<400>  73
cgtatctaga cggctttaag tgcgacattc                                        30


<210>  74
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer No. : Si_364

<400>  74
cgtatctaga ctaaagtatg aggagagaaa attgaa                                 36


<210>  75
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer No. : Si_365

<400>  75
gttaaagctt tcagcttgcc gtcgt                                             25


<210>  76
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer No. : Si_367

<400>  76
cgtatctaga gacccgttcc tggtgc                                            26


<210>  77
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer No. : Si_369

<400>  77
cgtatctaga ccccccaaga agaagc                                            26


<210>  78
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer No. : Si_373

<400>  78
gttaaagctt gctggagacg gtgacc                                            26


<210>  79
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer No. : Si_386

<400>  79
cgtatctaga tcaggacgct tcggaggtag                                        30


<210>  80
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer No. : Si_387

<400>  80
cgtatctaga atggactgtg aggtcaacaa                                        30


<210>  81
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer No. : Si_389

<400>  81
cgtatctaga ggcaaccgca gca                                               23


<210>  82
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer No. : Si_391

<400>  82
gttaaagctt tcagtccatc ccatttctg                                         29


<210>  83
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer No. : Si_403

<400>  83
cgtatctaga tctggaatat ccctggaca                                         29


<210>  84
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer No. : Si_406

<400>  84
gttaaagctt gtctgtctca atgccacagt                                        30


<210>  85
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer No. : Si_410

<400>  85
cagtctcgag atgtccgggg tggtg                                             25


<210>  86
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer No. : Si_413

<400>  86
cagtttcgaa tcactgcagc atgatgtc                                          28


<210>  87
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer No. : Si_417

<400>  87
cagtctcgag agtggtgttg atgatgacat g                                      31


<210>  88
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer No. : Si_420

<400>  88
cagtttcgaa ttagtgataa aaatagagtt cttttgtgag                             40


<210>  89
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer No. : Si_423

<400>  89
cagtctcgag atgcacataa ctaatttggg att                                    33


<210>  90
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer No. : Si_424

<400>  90
cagtttcgaa ttatacaaat gacgaatacc cttt                                   34


<210>  91
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer No. : Si_425

<400>  91
gttaaagctt ttacaccttg cgcttcttct tgggcgggct ggagacggtg ac               52


<210>  92
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer No. : Si_428

<400>  92
cgtatctaga atggacttca acaggaactt t                                      31


<210>  93
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer No. : Si_429

<400>  93
cgtatctaga ggacatagtc caccagcg                                          28


<210>  94
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer No. : Si_430

<400>  94
gttaaagctt tcagttggat ccgaaaaac                                         29


<210>  95
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer No. : Si_433

<400>  95
cgtatctaga gaattaaaaa aaacactcat ccca                                   34


<210>  96
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer No. : Si_434

<400>  96
cgtatctaga ccaaaggcaa aagcaaaaa                                         29


<210>  97
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer No. : Si_435

<400>  97
gttaaagctt ttagctagcc atggcaagc                                         29


<210>  98
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer No. : Si_436

<400>  98
cgtatctaga atgccccgcc cc                                                22


<210>  99
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer No. : Si_437

<400>  99
gttaaagctt ctacccaccg tactcgtcaa t                                      31


<210>  100
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer No. : Si_438

<400>  100
cgtatctaga atgtctgaca cgtccagaga g                                      31


<210>  101
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer No. : Si_439

<400>  101
gttaaagctt tcatcttctt cgcaggaaaa ag                                     32


<210>  102
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer No. : Si_445

<400>  102
cgcggatcct tatgggttct cacagcaaaa                                        30


<210>  103
<211>  43
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer No. : Si_446

<400>  103
catttattcc tcctagttag tcaaggcaac agccaatcaa gag                         43


<210>  104
<211>  43
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer No. : Si_447

<400>  104
ctcttgattg gctgttgcct tgactaacta ggaggaataa atg                         43


<210>  105
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer No. : Si_448

<400>  105
ttgattgcag tgacatggtg cattattccc tccaggtact a                           41


<210>  106
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer No. : Si_449

<400>  106
tagtacctgg agggaataat gcaccatgtc actgcaatca a                           41


<210>  107
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer No. : Si_450

<400>  107
cgtatctaga tagccgcaga tgttggtatg                                        30


<210>  108
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer No. : Si_451

<400>  108
cgtatctaga gatcaagtcc aactggtgg                                         29


<210>  109
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer No. : Si_463

<400>  109
cagtctcgag gaaagcttgt ttaaggggc                                         29


<210>  110
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer No. : Si_464

<400>  110
cagtttcgaa ttagcgacgg cgacg                                             25


<210>  111
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer No. : Si_476

<400>  111
gttaaagctt ttacttgtac agctcgtcca t                                      31


<210>  112
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer No. : Si_477

<400>  112
cgtatctaga gtgagcaagg gcgag                                             25


<210>  113
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer No. : Si_478

<400>  113
cagtctcgag atggaagatt ataccaaaat agagaaa                                37


<210>  114
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer No. : Si_479

<400>  114
gttaaagctt ctacatcttc ttaatctgat tgtcca                                 36


<210>  115
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer No. : Si_482

<400>  115
cgtatctaga atggcgctgc agct                                              24


<210>  116
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer No. : Si_483

<400>  116
gttaaagctt tcagtcattg acaggaattt tg                                     32


<210>  117
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer No. : Si_486

<400>  117
cgtatctaga atggagccgg cggcg                                             25


<210>  118
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer No. : Si_487

<400>  118
gttaaagctt tcaatcgggg atgtctg                                           27


<210>  119
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer No. : Si_492

<400>  119
cgtatctaga atgcgcgagg agaacaaggg                                        30


<210>  120
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer No. : Si_493

<400>  120
gttaaagctt tcagtcccct gtggctgtgc                                        30


<210>  121
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer No. : Si_494

<400>  121
cgtatctaga atggccgagc cttg                                              24


<210>  122
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer No. : Si_495

<400>  122
gttaaagctt ttattgaaga tttgtggctc c                                      31


<210>  123
<211>  64
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer No. : Si_504

<400>  123
cgtatctaga gaaaatctgt attttcaaag tgaaaatctg tattttcaaa gtatgccccg       60

cccc                                                                    64


<210>  124
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer No. : Si_505

<400>  124
gttaaagctt cccaccgtac tcgtcaattc                                        30


<210>  125
<211>  66
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer No. : Si_508

<400>  125
cgtatctaga gaaaatctgt attttcaaag tgaaaatctg tattttcaaa gtatggccga       60

gccttg                                                                  66


<210>  126
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer No. : Si_509

<400>  126
gttaaagctt ttgaagattt gtggctccc                                         29


<210>  127
<211>  67
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer No. : Si_511

<400>  127
cgtatctaga gaaaatctgt attttcaaag tgaaaatctg tattttcaaa gtgtgagcaa       60

gggcgag                                                                 67


<210>  128
<211>  91
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer No. : Si_512

<400>  128
cgtatctaga gaaaatctgt attttcaaag tgaaaatctg tattttcaaa gtccgccgaa       60

aaaaaaacgt aaagttgtga gcaagggcga g                                      91


<210>  129
<211>  55
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer No. : Si_513

<400>  129
gttaaagctt ttaaacttta cgtttttttt tcggcggctt gtacagctcg tccat            55


<210>  130
<211>  90
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer No. : Si_515

<400>  130
cgtatctaga gaaaatctgt attttcaaag tgaaaatctg tattttcaaa gtgattataa       60

agatgatgat gataaaatgg ccgagccttg                                        90


<210>  131
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer No. : Si_558

<400>  131
cgtatctaga atgaccagtt ttgaagatgc                                        30


<210>  132
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer No. : Si_559

<400>  132
gttaaagctt tcatgactca ttttcatcca t                                      31


<210>  133
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer No. : Si_561

<400>  133
cgtatctaga atgagtctct taaactgtga gaacag                                 36


<210>  134
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer No. : Si_562

<400>  134
gttaaagctt ctacaccccc gcatca                                            26


<210>  135
<211>  405
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YopE1-138 - SopE - MycHis

<400>  135

Met Lys Ile Ser Ser Phe Ile Ser Thr Ser Leu Pro Leu Pro Ala Ser 
1               5                   10                  15      


Val Ser Gly Ser Ser Ser Val Gly Glu Met Ser Gly Arg Ser Val Ser 
            20                  25                  30          


Gln Gln Lys Ser Asp Gln Tyr Ala Asn Asn Leu Ala Gly Arg Thr Glu 
        35                  40                  45              


Ser Pro Gln Gly Ser Ser Leu Ala Ser Arg Ile Ile Glu Arg Leu Ser 
    50                  55                  60                  


Ser Met Ala His Ser Val Ile Gly Phe Ile Gln Arg Met Phe Ser Glu 
65                  70                  75                  80  


Gly Ser His Lys Pro Val Val Thr Pro Ala Leu Thr Pro Ala Gln Met 
                85                  90                  95      


Pro Ser Pro Thr Ser Phe Ser Asp Ser Ile Lys Gln Leu Ala Ala Glu 
            100                 105                 110         


Thr Leu Pro Lys Tyr Met Gln Gln Leu Ser Ser Leu Asp Ala Glu Thr 
        115                 120                 125             


Leu Gln Lys Asn His Asp Gln Phe Ala Thr Leu Glu Val Thr Asn Ile 
    130                 135                 140                 


Thr Leu Ser Thr Gln His Tyr Arg Ile His Arg Ser Asp Val Glu Pro 
145                 150                 155                 160 


Val Lys Glu Lys Thr Thr Glu Lys Asp Ile Phe Ala Lys Ser Ile Thr 
                165                 170                 175     


Ala Val Arg Asn Ser Phe Ile Ser Leu Ser Thr Ser Leu Ser Asp Arg 
            180                 185                 190         


Phe Ser Leu His Gln Gln Thr Asp Ile Pro Thr Thr His Phe His Arg 
        195                 200                 205             


Gly Asn Ala Ser Glu Gly Arg Ala Val Leu Thr Ser Lys Thr Val Lys 
    210                 215                 220                 


Asp Phe Met Leu Gln Lys Leu Asn Ser Leu Asp Ile Lys Gly Asn Ala 
225                 230                 235                 240 


Ser Lys Asp Pro Ala Tyr Ala Arg Gln Thr Cys Glu Ala Ile Leu Ser 
                245                 250                 255     


Ala Val Tyr Ser Asn Asn Lys Asp Gln Cys Cys Lys Leu Leu Ile Ser 
            260                 265                 270         


Lys Gly Val Ser Ile Thr Pro Phe Leu Lys Glu Ile Gly Glu Ala Ala 
        275                 280                 285             


Gln Asn Ala Gly Leu Pro Gly Glu Ile Lys Asn Gly Val Phe Thr Pro 
    290                 295                 300                 


Gly Gly Ala Gly Ala Asn Pro Phe Val Val Pro Leu Ile Ala Ser Ala 
305                 310                 315                 320 


Ser Ile Lys Tyr Pro His Met Phe Ile Asn His Asn Gln Gln Val Ser 
                325                 330                 335     


Phe Lys Ala Tyr Ala Glu Lys Ile Val Met Lys Glu Val Thr Pro Leu 
            340                 345                 350         


Phe Asn Lys Gly Thr Met Pro Thr Pro Gln Gln Phe Gln Leu Thr Ile 
        355                 360                 365             


Glu Asn Ile Ala Asn Lys Tyr Leu Gln Asn Ala Ser Lys Leu Gly Pro 
    370                 375                 380                 


Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Asn Ser Ala Val Asp His 
385                 390                 395                 400 


His His His His His 
                405 


<210>  136
<211>  435
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YopE1-138 - BepG 715-end

<400>  136

Met Lys Ile Ser Ser Phe Ile Ser Thr Ser Leu Pro Leu Pro Ala Ser 
1               5                   10                  15      


Val Ser Gly Ser Ser Ser Val Gly Glu Met Ser Gly Arg Ser Val Ser 
            20                  25                  30          


Gln Gln Lys Ser Asp Gln Tyr Ala Asn Asn Leu Ala Gly Arg Thr Glu 
        35                  40                  45              


Ser Pro Gln Gly Ser Ser Leu Ala Ser Arg Ile Ile Glu Arg Leu Ser 
    50                  55                  60                  


Ser Met Ala His Ser Val Ile Gly Phe Ile Gln Arg Met Phe Ser Glu 
65                  70                  75                  80  


Gly Ser His Lys Pro Val Val Thr Pro Ala Leu Thr Pro Ala Gln Met 
                85                  90                  95      


Pro Ser Pro Thr Ser Phe Ser Asp Ser Ile Lys Gln Leu Ala Ala Glu 
            100                 105                 110         


Thr Leu Pro Lys Tyr Met Gln Gln Leu Ser Ser Leu Asp Ala Glu Thr 
        115                 120                 125             


Leu Gln Lys Asn His Asp Gln Phe Ala Thr Leu Glu Phe Thr Gln Glu 
    130                 135                 140                 


Thr Gln Lys Met Leu Ile Glu Lys Glu Ile Ile Pro Pro Leu Ser Tyr 
145                 150                 155                 160 


Val Asp Val Ala Ser Lys Ile Arg Glu Ser Glu Val Val Lys Ser Ser 
                165                 170                 175     


Met Gln Lys Ile Lys Thr Leu Cys Gly Val Val Tyr Gly Asn Pro Asp 
            180                 185                 190         


Ile Leu Glu Gly Lys Met Pro Lys Met Gly Ile Pro Val Thr Asn Lys 
        195                 200                 205             


Asn Val Glu Glu Leu Glu Lys Phe Ala Arg Gln Val Gly Asn Phe Pro 
    210                 215                 220                 


Ser Ser Cys Gly Lys Ile Val Gly Phe Ser Phe Leu Gly Ile Lys Ser 
225                 230                 235                 240 


Glu Ala Arg Ala His Ala Glu Glu Asn Phe Leu Pro Leu Ser His Ala 
                245                 250                 255     


Ile Phe Ser Tyr Ala His Asn Val Lys Gln Ala Glu Lys Asp Ile Leu 
            260                 265                 270         


Glu Ala Tyr Phe Lys Glu Gln Glu Arg Cys Ala Gln Ser Val Glu Thr 
        275                 280                 285             


Pro Ser Glu Glu Ile Thr Asn Leu Leu Ser Phe Thr Gln Glu Gln Gln 
    290                 295                 300                 


Lys Glu Ile Leu Ser Asn Ser Pro Lys Leu Arg Thr Gln Val Lys Ala 
305                 310                 315                 320 


Tyr Ser Gln Lys Leu His Asn Arg Leu Ser Pro Asn Asp Leu Gln Ala 
                325                 330                 335     


Ile Ser Glu Arg Ser His Thr Lys Leu Ala Glu Ser Leu Gly Thr Ser 
            340                 345                 350         


Val Asn Gln Ala Glu Lys Ile Ala Gln Ile Leu Thr Gln Thr Lys Asp 
        355                 360                 365             


Val Val Gln Ile Leu Gln Gln Gln Glu Lys Leu Gly Leu Tyr Gln Ser 
    370                 375                 380                 


Ile Met Lys Gly Asp Gly Arg Glu Thr Ala Lys Val Asn Met Ser Ala 
385                 390                 395                 400 


Ile Lys Ala Thr Gln Met Thr Thr Lys Val Thr Ser Leu Lys Ala Val 
                405                 410                 415     


Glu Gln Ile Val Arg Pro Pro Lys Val Glu Thr Ala Lys Val Val Ser 
            420                 425                 430         


Met Ser Arg 
        435 


<210>  137
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YopE1-138 - Rac1 Q61E - MycHis

<400>  137

Met Lys Ile Ser Ser Phe Ile Ser Thr Ser Leu Pro Leu Pro Ala Ser 
1               5                   10                  15      


Val Ser Gly Ser Ser Ser Val Gly Glu Met Ser Gly Arg Ser Val Ser 
            20                  25                  30          


Gln Gln Lys Ser Asp Gln Tyr Ala Asn Asn Leu Ala Gly Arg Thr Glu 
        35                  40                  45              


Ser Pro Gln Gly Ser Ser Leu Ala Ser Arg Ile Ile Glu Arg Leu Ser 
    50                  55                  60                  


Ser Met Ala His Ser Val Ile Gly Phe Ile Gln Arg Met Phe Ser Glu 
65                  70                  75                  80  


Gly Ser His Lys Pro Val Val Thr Pro Ala Leu Thr Pro Ala Gln Met 
                85                  90                  95      


Pro Ser Pro Thr Ser Phe Ser Asp Ser Ile Lys Gln Leu Ala Ala Glu 
            100                 105                 110         


Thr Leu Pro Lys Tyr Met Gln Gln Leu Ser Ser Leu Asp Ala Glu Thr 
        115                 120                 125             


Leu Gln Lys Asn His Asp Gln Phe Ala Thr Leu Glu Gln Ala Ile Lys 
    130                 135                 140                 


Cys Val Val Val Gly Asp Gly Ala Val Gly Lys Thr Cys Leu Leu Ile 
145                 150                 155                 160 


Ser Tyr Thr Thr Asn Ala Phe Pro Gly Glu Tyr Ile Pro Thr Val Phe 
                165                 170                 175     


Asp Asn Tyr Ser Ala Asn Val Met Val Asp Gly Lys Pro Val Asn Leu 
            180                 185                 190         


Gly Leu Trp Asp Thr Ala Gly Glu Glu Asp Tyr Asp Arg Leu Arg Pro 
        195                 200                 205             


Leu Ser Tyr Pro Gln Thr Asp Val Phe Leu Ile Cys Phe Ser Leu Val 
    210                 215                 220                 


Ser Pro Ala Ser Phe Glu Asn Val Arg Ala Lys Trp Tyr Pro Glu Val 
225                 230                 235                 240 


Arg His His Cys Pro Asn Thr Pro Ile Ile Leu Val Gly Thr Lys Leu 
                245                 250                 255     


Asp Leu Arg Asp Asp Lys Asp Thr Ile Glu Lys Leu Lys Glu Lys Lys 
            260                 265                 270         


Leu Thr Pro Ile Thr Tyr Pro Gln Gly Leu Ala Met Ala Lys Glu Ile 
        275                 280                 285             


Gly Ala Val Lys Tyr Leu Glu Cys Ser Ala Leu Thr Gln Arg Gly Leu 
    290                 295                 300                 


Lys Thr Val Phe Asp Glu Ala Ile Arg Ala Val Leu Cys Pro Pro Pro 
305                 310                 315                 320 


Val Lys Lys Arg Lys Arg Lys Phe Glu Lys Leu Gly Pro Glu Gln Lys 
                325                 330                 335     


Leu Ile Ser Glu Glu Asp Leu Asn Ser Ala Val Asp His His His His 
            340                 345                 350         


His His 
        

<210>  138
<211>  163
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YopE1-138 - Y. enterocolitica codon optimized murine BID BH3 part

<400>  138

Met Lys Ile Ser Ser Phe Ile Ser Thr Ser Leu Pro Leu Pro Ala Ser 
1               5                   10                  15      


Val Ser Gly Ser Ser Ser Val Gly Glu Met Ser Gly Arg Ser Val Ser 
            20                  25                  30          


Gln Gln Lys Ser Asp Gln Tyr Ala Asn Asn Leu Ala Gly Arg Thr Glu 
        35                  40                  45              


Ser Pro Gln Gly Ser Ser Leu Ala Ser Arg Ile Ile Glu Arg Leu Ser 
    50                  55                  60                  


Ser Met Ala His Ser Val Ile Gly Phe Ile Gln Arg Met Phe Ser Glu 
65                  70                  75                  80  


Gly Ser His Lys Pro Val Val Thr Pro Ala Leu Thr Pro Ala Gln Met 
                85                  90                  95      


Pro Ser Pro Thr Ser Phe Ser Asp Ser Ile Lys Gln Leu Ala Ala Glu 
            100                 105                 110         


Thr Leu Pro Lys Tyr Met Gln Gln Leu Ser Ser Leu Asp Ala Glu Thr 
        115                 120                 125             


Leu Gln Lys Asn His Asp Gln Phe Ala Thr Leu Glu Ser Arg Phe Glu 
    130                 135                 140                 


Glu Ile Ile His Asn Ile Ala Arg His Leu Ala Gln Ile Gly Asp Glu 
145                 150                 155                 160 


Met Asp His 
            


<210>  139
<211>  156
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YopE1-138 - Y. enterocolitica codon optimized murine Bax BH3 part

<400>  139

Met Lys Ile Ser Ser Phe Ile Ser Thr Ser Leu Pro Leu Pro Ala Ser 
1               5                   10                  15      


Val Ser Gly Ser Ser Ser Val Gly Glu Met Ser Gly Arg Ser Val Ser 
            20                  25                  30          


Gln Gln Lys Ser Asp Gln Tyr Ala Asn Asn Leu Ala Gly Arg Thr Glu 
        35                  40                  45              


Ser Pro Gln Gly Ser Ser Leu Ala Ser Arg Ile Ile Glu Arg Leu Ser 
    50                  55                  60                  


Ser Met Ala His Ser Val Ile Gly Phe Ile Gln Arg Met Phe Ser Glu 
65                  70                  75                  80  


Gly Ser His Lys Pro Val Val Thr Pro Ala Leu Thr Pro Ala Gln Met 
                85                  90                  95      


Pro Ser Pro Thr Ser Phe Ser Asp Ser Ile Lys Gln Leu Ala Ala Glu 
            100                 105                 110         


Thr Leu Pro Lys Tyr Met Gln Gln Leu Ser Ser Leu Asp Ala Glu Thr 
        115                 120                 125             


Leu Gln Lys Asn His Asp Gln Phe Ala Thr Leu Glu Lys Lys Leu Ser 
    130                 135                 140                 


Glu Cys Leu Arg Arg Ile Gly Asp Glu Leu Asp Ser 
145                 150                 155     


<210>  140
<211>  20
<212>  PRT
<213>  Salmonella enterica

<220>
<223>  SteA1-20

<400>  140

Met Pro Tyr Thr Ser Val Ser Thr Tyr Ala Arg Ala Leu Ser Gly Asn 
1               5                   10                  15      


Lys Leu Pro His 
            20  


<210>  141
<211>  210
<212>  PRT
<213>  Salmonella enterica

<220>
<223>  SteA

<400>  141

Met Pro Tyr Thr Ser Val Ser Thr Tyr Ala Arg Ala Leu Ser Gly Asn 
1               5                   10                  15      


Lys Leu Pro His Val Ala Ala Gly Asp Tyr Glu Asn Lys Leu Ser Thr 
            20                  25                  30          


Lys Ile Met Lys Gly Ile Leu Tyr Val Leu Thr Ala Gly Leu Ala Tyr 
        35                  40                  45              


Gly Phe Thr Arg Val Ile Glu His Tyr Cys Asn Val Thr Pro Lys Val 
    50                  55                  60                  


Ala Glu Phe Cys Ala Asn Ala Gly Asn Ile His Asn His Leu Ala Asp 
65                  70                  75                  80  


Ala Val Arg Asp Gly Leu Phe Thr Ile Asp Val Glu Leu Ser Asp Gly 
                85                  90                  95      


Arg Met Leu Thr Phe Glu Gln Leu Ser Leu Ile Ala Glu Gly Lys Pro 
            100                 105                 110         


Ile Val Arg Ile Ser Asp Gly Glu His Thr Val Glu Val Glu Gly Thr 
        115                 120                 125             


Phe Glu Glu Ile Cys Met Arg Leu Glu Glu Gly Phe Phe Glu Ala Pro 
    130                 135                 140                 


Ala Tyr Tyr Asp Tyr Asp Ile Asp Glu Lys Tyr Lys Thr Val Arg Glu 
145                 150                 155                 160 


Arg Met Ala Ala Tyr Asn Ala Leu Pro Gln Ala Leu Gly Ala Ile Pro 
                165                 170                 175     


Cys Leu Glu Tyr Tyr Ile Ala Arg Ala Ser Asn Met Gln Glu Ala Lys 
            180                 185                 190         


Ala Gln Trp Ala Ala Asp Ile Lys Ala Arg Tyr His Asn Tyr Leu Asp 
        195                 200                 205             


Asn Tyr 
    210 


<210>  142
<211>  81
<212>  PRT
<213>  Salmonella enterica

<220>
<223>  SopE1-81

<400>  142

Val Thr Lys Ile Thr Leu Ser Pro Gln Asn Phe Arg Ile Gln Lys Gln 
1               5                   10                  15      


Glu Thr Thr Leu Leu Lys Glu Lys Ser Thr Glu Lys Asn Ser Leu Ala 
            20                  25                  30          


Lys Ser Ile Leu Ala Val Lys Asn His Phe Ile Glu Leu Arg Ser Lys 
        35                  40                  45              


Leu Ser Glu Arg Phe Ile Ser His Lys Asn Thr Glu Ser Ser Ala Thr 
    50                  55                  60                  


His Phe His Arg Gly Ser Ala Ser Glu Gly Arg Ala Val Leu Thr Asn 
65                  70                  75                  80  


Lys


<210>  143
<211>  105
<212>  PRT
<213>  Salmonella enterica

<220>
<223>  SopE1-105

<400>  143

Val Thr Lys Ile Thr Leu Ser Pro Gln Asn Phe Arg Ile Gln Lys Gln 
1               5                   10                  15      


Glu Thr Thr Leu Leu Lys Glu Lys Ser Thr Glu Lys Asn Ser Leu Ala 
            20                  25                  30          


Lys Ser Ile Leu Ala Val Lys Asn His Phe Ile Glu Leu Arg Ser Lys 
        35                  40                  45              


Leu Ser Glu Arg Phe Ile Ser His Lys Asn Thr Glu Ser Ser Ala Thr 
    50                  55                  60                  


His Phe His Arg Gly Ser Ala Ser Glu Gly Arg Ala Val Leu Thr Asn 
65                  70                  75                  80  


Lys Val Val Lys Asp Phe Met Leu Gln Thr Leu Asn Asp Ile Asp Ile 
                85                  90                  95      


Arg Gly Ser Ala Ser Lys Asp Pro Ala 
            100                 105 


<210>  144
<211>  158
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SteA1-20 - S. enterica codon optimized murine t-BID

<400>  144

Met Pro Tyr Thr Ser Val Ser Thr Tyr Ala Arg Ala Leu Ser Gly Asn 
1               5                   10                  15      


Lys Leu Pro His Gly Thr Gly Ser Gln Ala Ser Arg Ser Phe Asn Gln 
            20                  25                  30          


Gly Arg Ile Glu Pro Asp Ser Glu Ser Gln Glu Glu Ile Ile His Asn 
        35                  40                  45              


Ile Ala Arg His Leu Ala Gln Ile Gly Asp Glu Met Asp His Asn Ile 
    50                  55                  60                  


Gln Pro Thr Leu Val Arg Gln Leu Ala Ala Gln Phe Met Asn Gly Ser 
65                  70                  75                  80  


Leu Ser Glu Glu Asp Lys Arg Asn Cys Leu Ala Lys Ala Leu Asp Glu 
                85                  90                  95      


Val Lys Thr Ala Phe Pro Arg Asp Met Glu Asn Asp Lys Ala Met Leu 
            100                 105                 110         


Ile Met Thr Met Leu Leu Ala Lys Lys Val Ala Ser His Ala Pro Ser 
        115                 120                 125             


Leu Leu Arg Asp Val Phe His Thr Thr Val Asn Phe Ile Asn Gln Asn 
    130                 135                 140                 


Leu Phe Ser Tyr Val Arg Asn Leu Val Arg Asn Glu Met Asp 
145                 150                 155             


<210>  145
<211>  348
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SteA - S. enterica codon optimized murine t-BID

<400>  145

Met Pro Tyr Thr Ser Val Ser Thr Tyr Ala Arg Ala Leu Ser Gly Asn 
1               5                   10                  15      


Lys Leu Pro His Val Ala Ala Gly Asp Tyr Glu Asn Lys Leu Ser Thr 
            20                  25                  30          


Lys Ile Met Lys Gly Ile Leu Tyr Val Leu Thr Ala Gly Leu Ala Tyr 
        35                  40                  45              


Gly Phe Thr Arg Val Ile Glu His Tyr Cys Asn Val Thr Pro Lys Val 
    50                  55                  60                  


Ala Glu Phe Cys Ala Asn Ala Gly Asn Ile His Asn His Leu Ala Asp 
65                  70                  75                  80  


Ala Val Arg Asp Gly Leu Phe Thr Ile Asp Val Glu Leu Ser Asp Gly 
                85                  90                  95      


Arg Met Leu Thr Phe Glu Gln Leu Ser Leu Ile Ala Glu Gly Lys Pro 
            100                 105                 110         


Ile Val Arg Ile Ser Asp Gly Glu His Thr Val Glu Val Glu Gly Thr 
        115                 120                 125             


Phe Glu Glu Ile Cys Met Arg Leu Glu Glu Gly Phe Phe Glu Ala Pro 
    130                 135                 140                 


Ala Tyr Tyr Asp Tyr Asp Ile Asp Glu Lys Tyr Lys Thr Val Arg Glu 
145                 150                 155                 160 


Arg Met Ala Ala Tyr Asn Ala Leu Pro Gln Ala Leu Gly Ala Ile Pro 
                165                 170                 175     


Cys Leu Glu Tyr Tyr Ile Ala Arg Ala Ser Asn Met Gln Glu Ala Lys 
            180                 185                 190         


Ala Gln Trp Ala Ala Asp Ile Lys Ala Arg Tyr His Asn Tyr Leu Asp 
        195                 200                 205             


Asn Tyr Gly Thr Gly Ser Gln Ala Ser Arg Ser Phe Asn Gln Gly Arg 
    210                 215                 220                 


Ile Glu Pro Asp Ser Glu Ser Gln Glu Glu Ile Ile His Asn Ile Ala 
225                 230                 235                 240 


Arg His Leu Ala Gln Ile Gly Asp Glu Met Asp His Asn Ile Gln Pro 
                245                 250                 255     


Thr Leu Val Arg Gln Leu Ala Ala Gln Phe Met Asn Gly Ser Leu Ser 
            260                 265                 270         


Glu Glu Asp Lys Arg Asn Cys Leu Ala Lys Ala Leu Asp Glu Val Lys 
        275                 280                 285             


Thr Ala Phe Pro Arg Asp Met Glu Asn Asp Lys Ala Met Leu Ile Met 
    290                 295                 300                 


Thr Met Leu Leu Ala Lys Lys Val Ala Ser His Ala Pro Ser Leu Leu 
305                 310                 315                 320 


Arg Asp Val Phe His Thr Thr Val Asn Phe Ile Asn Gln Asn Leu Phe 
                325                 330                 335     


Ser Tyr Val Arg Asn Leu Val Arg Asn Glu Met Asp 
            340                 345             


<210>  146
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SopE1-81 - S. enterica codon optimized murine t-BID

<400>  146

Val Thr Lys Ile Thr Leu Ser Pro Gln Asn Phe Arg Ile Gln Lys Gln 
1               5                   10                  15      


Glu Thr Thr Leu Leu Lys Glu Lys Ser Thr Glu Lys Asn Ser Leu Ala 
            20                  25                  30          


Lys Ser Ile Leu Ala Val Lys Asn His Phe Ile Glu Leu Arg Ser Lys 
        35                  40                  45              


Leu Ser Glu Arg Phe Ile Ser His Lys Asn Thr Glu Ser Ser Ala Thr 
    50                  55                  60                  


His Phe His Arg Gly Ser Ala Ser Glu Gly Arg Ala Val Leu Thr Asn 
65                  70                  75                  80  


Lys Gly Thr Gly Ser Gln Ala Ser Arg Ser Phe Asn Gln Gly Arg Ile 
                85                  90                  95      


Glu Pro Asp Ser Glu Ser Gln Glu Glu Ile Ile His Asn Ile Ala Arg 
            100                 105                 110         


His Leu Ala Gln Ile Gly Asp Glu Met Asp His Asn Ile Gln Pro Thr 
        115                 120                 125             


Leu Val Arg Gln Leu Ala Ala Gln Phe Met Asn Gly Ser Leu Ser Glu 
    130                 135                 140                 


Glu Asp Lys Arg Asn Cys Leu Ala Lys Ala Leu Asp Glu Val Lys Thr 
145                 150                 155                 160 


Ala Phe Pro Arg Asp Met Glu Asn Asp Lys Ala Met Leu Ile Met Thr 
                165                 170                 175     


Met Leu Leu Ala Lys Lys Val Ala Ser His Ala Pro Ser Leu Leu Arg 
            180                 185                 190         


Asp Val Phe His Thr Thr Val Asn Phe Ile Asn Gln Asn Leu Phe Ser 
        195                 200                 205             


Tyr Val Arg Asn Leu Val Arg Asn Glu Met Asp 
    210                 215                 


<210>  147
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SopE1-105 - S. enterica codon optimized murine t-BID

<400>  147

Val Thr Lys Ile Thr Leu Ser Pro Gln Asn Phe Arg Ile Gln Lys Gln 
1               5                   10                  15      


Glu Thr Thr Leu Leu Lys Glu Lys Ser Thr Glu Lys Asn Ser Leu Ala 
            20                  25                  30          


Lys Ser Ile Leu Ala Val Lys Asn His Phe Ile Glu Leu Arg Ser Lys 
        35                  40                  45              


Leu Ser Glu Arg Phe Ile Ser His Lys Asn Thr Glu Ser Ser Ala Thr 
    50                  55                  60                  


His Phe His Arg Gly Ser Ala Ser Glu Gly Arg Ala Val Leu Thr Asn 
65                  70                  75                  80  


Lys Val Val Lys Asp Phe Met Leu Gln Thr Leu Asn Asp Ile Asp Ile 
                85                  90                  95      


Arg Gly Ser Ala Ser Lys Asp Pro Ala Gly Thr Gly Ser Gln Ala Ser 
            100                 105                 110         


Arg Ser Phe Asn Gln Gly Arg Ile Glu Pro Asp Ser Glu Ser Gln Glu 
        115                 120                 125             


Glu Ile Ile His Asn Ile Ala Arg His Leu Ala Gln Ile Gly Asp Glu 
    130                 135                 140                 


Met Asp His Asn Ile Gln Pro Thr Leu Val Arg Gln Leu Ala Ala Gln 
145                 150                 155                 160 


Phe Met Asn Gly Ser Leu Ser Glu Glu Asp Lys Arg Asn Cys Leu Ala 
                165                 170                 175     


Lys Ala Leu Asp Glu Val Lys Thr Ala Phe Pro Arg Asp Met Glu Asn 
            180                 185                 190         


Asp Lys Ala Met Leu Ile Met Thr Met Leu Leu Ala Lys Lys Val Ala 
        195                 200                 205             


Ser His Ala Pro Ser Leu Leu Arg Asp Val Phe His Thr Thr Val Asn 
    210                 215                 220                 


Phe Ile Asn Gln Asn Leu Phe Ser Tyr Val Arg Asn Leu Val Arg Asn 
225                 230                 235                 240 


Glu Met Asp 
            


<210>  148
<211>  82
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer No. : Si_677

<400>  148
ttactattcg aagaaattat tcataatatt gcccgccatc tggcccaaat tggtgatgaa       60

atggatcatt aagcttggag ta                                                82


<210>  149
<211>  82
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer No. : Si_678

<400>  149
tactccaagc ttaatgatcc atttcatcac caatttgggc cagatggcgg gcaatattat       60

gaataatttc ttcgaatagt aa                                                82


<210>  150
<211>  73
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer No. : Si_682

<400>  150
ttactactcg agaaaaaact gagcgaatgt ctgcgccgca ttggtgatga actggatagc       60

taagcttgga gta                                                          73


<210>  151
<211>  73
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer No. : Si_683

<400>  151
tactccaagc ttagctatcc agttcatcac caatgcggcg cagacattcg ctcagttttt       60

tctcgagtag taa                                                          73


<210>  152
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer No. : Si_580

<400>  152
catgccatgg atttatggtc atagatatga cctc                                   34


<210>  153
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer No. : Si_612

<400>  153
cggggtacca tgaggtagct tatttcctga taaag                                  35


<210>  154
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer No. : Si_613

<400>  154
cggggtacca taattgtcca aatagttatg gtagc                                  35


<210>  155
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer No. : Si_614

<400>  155
catgccatggc ggcaaggctc ctc                                               24


<210>  156
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer No. : Si_615

<400>  156
cggggtacct ttatttgtca acactgccc                                         29


<210>  157
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer No. : Si_616

<400>  157
cggggtacct gcggggtctt tactcg                                            26


<210>  158
<211>  164
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YopE1-138-Y. enterocolitica codon optimized Ink4A 84-103

<400>  158

Met Lys Ile Ser Ser Phe Ile Ser Thr Ser Leu Pro Leu Pro Ala Ser 
1               5                   10                  15      


Val Ser Gly Ser Ser Ser Val Gly Glu Met Ser Gly Arg Ser Val Ser 
            20                  25                  30          


Gln Gln Lys Ser Asp Gln Tyr Ala Asn Asn Leu Ala Gly Arg Thr Glu 
        35                  40                  45              


Ser Pro Gln Gly Ser Ser Leu Ala Ser Arg Ile Ile Glu Arg Leu Ser 
    50                  55                  60                  


Ser Met Ala His Ser Val Ile Gly Phe Ile Gln Arg Met Phe Ser Glu 
65                  70                  75                  80  


Gly Ser His Lys Pro Val Val Thr Pro Ala Leu Thr Pro Ala Gln Met 
                85                  90                  95      


Pro Ser Pro Thr Ser Phe Ser Asp Ser Ile Lys Gln Leu Ala Ala Glu 
            100                 105                 110         


Thr Leu Pro Lys Tyr Met Gln Gln Leu Ser Ser Leu Asp Ala Glu Thr 
        115                 120                 125             


Leu Gln Lys Asn His Asp Gln Phe Ala Thr Leu Glu Gly Ala Ile Asp 
    130                 135                 140                 


Asp Ala Ala Arg Glu Gly Phe Leu Asp Thr Leu Val Val Leu His Arg 
145                 150                 155                 160 


Ala Gly Ala Arg 
                


<210>  159
<211>  164
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YopE1-138-Y. enterocolitica codon optimized p107/RBL1 657-662 
       (AAA02489.1)

<400>  159

Met Lys Ile Ser Ser Phe Ile Ser Thr Ser Leu Pro Leu Pro Ala Ser 
1               5                   10                  15      


Val Ser Gly Ser Ser Ser Val Gly Glu Met Ser Gly Arg Ser Val Ser 
            20                  25                  30          


Gln Gln Lys Ser Asp Gln Tyr Ala Asn Asn Leu Ala Gly Arg Thr Glu 
        35                  40                  45              


Ser Pro Gln Gly Ser Ser Leu Ala Ser Arg Ile Ile Glu Arg Leu Ser 
    50                  55                  60                  


Ser Met Ala His Ser Val Ile Gly Phe Ile Gln Arg Met Phe Ser Glu 
65                  70                  75                  80  


Gly Ser His Lys Pro Val Val Thr Pro Ala Leu Thr Pro Ala Gln Met 
                85                  90                  95      


Pro Ser Pro Thr Ser Phe Ser Asp Ser Ile Lys Gln Leu Ala Ala Glu 
            100                 105                 110         


Thr Leu Pro Lys Tyr Met Gln Gln Leu Ser Ser Leu Asp Ala Glu Thr 
        115                 120                 125             


Leu Gln Lys Asn His Asp Gln Phe Ala Thr Leu Glu Gly Ala Ile Asp 
    130                 135                 140                 


Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Gly Pro Val Lys Arg 
145                 150                 155                 160 


Arg Leu Phe Gly 
                


<210>  160
<211>  164
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YopE1-138-Y. enterocolitica codon optimized p21 141-160 
       (AAH13967.1)

<400>  160

Met Lys Ile Ser Ser Phe Ile Ser Thr Ser Leu Pro Leu Pro Ala Ser 
1               5                   10                  15      


Val Ser Gly Ser Ser Ser Val Gly Glu Met Ser Gly Arg Ser Val Ser 
            20                  25                  30          


Gln Gln Lys Ser Asp Gln Tyr Ala Asn Asn Leu Ala Gly Arg Thr Glu 
        35                  40                  45              


Ser Pro Gln Gly Ser Ser Leu Ala Ser Arg Ile Ile Glu Arg Leu Ser 
    50                  55                  60                  


Ser Met Ala His Ser Val Ile Gly Phe Ile Gln Arg Met Phe Ser Glu 
65                  70                  75                  80  


Gly Ser His Lys Pro Val Val Thr Pro Ala Leu Thr Pro Ala Gln Met 
                85                  90                  95      


Pro Ser Pro Thr Ser Phe Ser Asp Ser Ile Lys Gln Leu Ala Ala Glu 
            100                 105                 110         


Thr Leu Pro Lys Tyr Met Gln Gln Leu Ser Ser Leu Asp Ala Glu Thr 
        115                 120                 125             


Leu Gln Lys Asn His Asp Gln Phe Ala Thr Leu Glu Gly Ala Ile Asp 
    130                 135                 140                 


Lys Arg Arg Gln Thr Ser Met Thr Ala Phe Tyr His Ser Lys Arg Arg 
145                 150                 155                 160 


Leu Ile Phe Ser 
                


<210>  161
<211>  160
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YopE1-138-Y. enterocolitica codon optimized p21 145-160 
       (AAH13967.1)

<400>  161

Met Lys Ile Ser Ser Phe Ile Ser Thr Ser Leu Pro Leu Pro Ala Ser 
1               5                   10                  15      


Val Ser Gly Ser Ser Ser Val Gly Glu Met Ser Gly Arg Ser Val Ser 
            20                  25                  30          


Gln Gln Lys Ser Asp Gln Tyr Ala Asn Asn Leu Ala Gly Arg Thr Glu 
        35                  40                  45              


Ser Pro Gln Gly Ser Ser Leu Ala Ser Arg Ile Ile Glu Arg Leu Ser 
    50                  55                  60                  


Ser Met Ala His Ser Val Ile Gly Phe Ile Gln Arg Met Phe Ser Glu 
65                  70                  75                  80  


Gly Ser His Lys Pro Val Val Thr Pro Ala Leu Thr Pro Ala Gln Met 
                85                  90                  95      


Pro Ser Pro Thr Ser Phe Ser Asp Ser Ile Lys Gln Leu Ala Ala Glu 
            100                 105                 110         


Thr Leu Pro Lys Tyr Met Gln Gln Leu Ser Ser Leu Asp Ala Glu Thr 
        115                 120                 125             


Leu Gln Lys Asn His Asp Gln Phe Ala Thr Leu Glu Gly Ala Ile Asp 
    130                 135                 140                 


Thr Ser Met Thr Ala Phe Tyr His Ser Lys Arg Arg Leu Ile Phe Ser 
145                 150                 155                 160 


<210>  162
<211>  161
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YopE1-138-Y. enterocolitica codon optimized p21 17-33 
       (AAH13967.1)

<400>  162

Met Lys Ile Ser Ser Phe Ile Ser Thr Ser Leu Pro Leu Pro Ala Ser 
1               5                   10                  15      


Val Ser Gly Ser Ser Ser Val Gly Glu Met Ser Gly Arg Ser Val Ser 
            20                  25                  30          


Gln Gln Lys Ser Asp Gln Tyr Ala Asn Asn Leu Ala Gly Arg Thr Glu 
        35                  40                  45              


Ser Pro Gln Gly Ser Ser Leu Ala Ser Arg Ile Ile Glu Arg Leu Ser 
    50                  55                  60                  


Ser Met Ala His Ser Val Ile Gly Phe Ile Gln Arg Met Phe Ser Glu 
65                  70                  75                  80  


Gly Ser His Lys Pro Val Val Thr Pro Ala Leu Thr Pro Ala Gln Met 
                85                  90                  95      


Pro Ser Pro Thr Ser Phe Ser Asp Ser Ile Lys Gln Leu Ala Ala Glu 
            100                 105                 110         


Thr Leu Pro Lys Tyr Met Gln Gln Leu Ser Ser Leu Asp Ala Glu Thr 
        115                 120                 125             


Leu Gln Lys Asn His Asp Gln Phe Ala Thr Leu Glu Gly Ala Ile Asp 
    130                 135                 140                 


Ala Cys Arg Arg Leu Phe Gly Pro Val Asp Ser Glu Gln Leu Ser Arg 
145                 150                 155                 160 


Asp 
    


<210>  163
<211>  153
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YopE1-138-Y. enterocolitica codon optimized cyclin D2 139-147 ( 
       CAA48493.1)

<400>  163

Met Lys Ile Ser Ser Phe Ile Ser Thr Ser Leu Pro Leu Pro Ala Ser 
1               5                   10                  15      


Val Ser Gly Ser Ser Ser Val Gly Glu Met Ser Gly Arg Ser Val Ser 
            20                  25                  30          


Gln Gln Lys Ser Asp Gln Tyr Ala Asn Asn Leu Ala Gly Arg Thr Glu 
        35                  40                  45              


Ser Pro Gln Gly Ser Ser Leu Ala Ser Arg Ile Ile Glu Arg Leu Ser 
    50                  55                  60                  


Ser Met Ala His Ser Val Ile Gly Phe Ile Gln Arg Met Phe Ser Glu 
65                  70                  75                  80  


Gly Ser His Lys Pro Val Val Thr Pro Ala Leu Thr Pro Ala Gln Met 
                85                  90                  95      


Pro Ser Pro Thr Ser Phe Ser Asp Ser Ile Lys Gln Leu Ala Ala Glu 
            100                 105                 110         


Thr Leu Pro Lys Tyr Met Gln Gln Leu Ser Ser Leu Asp Ala Glu Thr 
        115                 120                 125             


Leu Gln Lys Asn His Asp Gln Phe Ala Thr Leu Glu Gly Ala Ile Asp 
    130                 135                 140                 


Trp Glu Leu Val Val Leu Gly Lys Leu 
145                 150             


<210>  164
<211>  397
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SteA-Ink4a-MycHis

<400>  164

Met Pro Tyr Thr Ser Val Ser Thr Tyr Ala Arg Ala Leu Ser Gly Asn 
1               5                   10                  15      


Lys Leu Pro His Val Ala Ala Gly Asp Tyr Glu Asn Lys Leu Ser Thr 
            20                  25                  30          


Lys Ile Met Lys Gly Ile Leu Tyr Val Leu Thr Ala Gly Leu Ala Tyr 
        35                  40                  45              


Gly Phe Thr Arg Val Ile Glu His Tyr Cys Asn Val Thr Pro Lys Val 
    50                  55                  60                  


Ala Glu Phe Cys Ala Asn Ala Gly Asn Ile His Asn His Leu Ala Asp 
65                  70                  75                  80  


Ala Val Arg Asp Gly Leu Phe Thr Ile Asp Val Glu Leu Ser Asp Gly 
                85                  90                  95      


Arg Met Leu Thr Phe Glu Gln Leu Ser Leu Ile Ala Glu Gly Lys Pro 
            100                 105                 110         


Ile Val Arg Ile Ser Asp Gly Glu His Thr Val Glu Val Glu Gly Thr 
        115                 120                 125             


Phe Glu Glu Ile Cys Met Arg Leu Glu Glu Gly Phe Phe Glu Ala Pro 
    130                 135                 140                 


Ala Tyr Tyr Asp Tyr Asp Ile Asp Glu Lys Tyr Lys Thr Val Arg Glu 
145                 150                 155                 160 


Arg Met Ala Ala Tyr Asn Ala Leu Pro Gln Ala Leu Gly Ala Ile Pro 
                165                 170                 175     


Cys Leu Glu Tyr Tyr Ile Ala Arg Ala Ser Asn Met Gln Glu Ala Lys 
            180                 185                 190         


Ala Gln Trp Ala Ala Asp Ile Lys Ala Arg Tyr His Asn Tyr Leu Asp 
        195                 200                 205             


Asn Tyr Gly Thr Ile Trp Glu Phe Met Glu Pro Ala Ala Gly Ser Ser 
    210                 215                 220                 


Met Glu Pro Ser Ala Asp Trp Leu Ala Thr Ala Ala Ala Arg Gly Arg 
225                 230                 235                 240 


Val Glu Glu Val Arg Ala Leu Leu Glu Ala Gly Ala Leu Pro Asn Ala 
                245                 250                 255     


Pro Asn Ser Tyr Gly Arg Arg Pro Ile Gln Val Met Met Met Gly Ser 
            260                 265                 270         


Ala Arg Val Ala Glu Leu Leu Leu Leu His Gly Ala Glu Pro Asn Cys 
        275                 280                 285             


Ala Asp Pro Ala Thr Leu Thr Arg Pro Val His Asp Ala Ala Arg Glu 
    290                 295                 300                 


Gly Phe Leu Asp Thr Leu Val Val Leu His Arg Ala Gly Ala Arg Leu 
305                 310                 315                 320 


Asp Val Arg Asp Ala Trp Gly Arg Leu Pro Val Asp Leu Ala Glu Glu 
                325                 330                 335     


Leu Gly His Arg Asp Val Ala Arg Tyr Leu Arg Ala Ala Ala Gly Gly 
            340                 345                 350         


Thr Arg Gly Ser Asn His Ala Arg Ile Asp Ala Ala Glu Gly Pro Ser 
        355                 360                 365             


Asp Ile Pro Asp Lys Leu Gly Pro Glu Gln Lys Leu Ile Ser Glu Glu 
    370                 375                 380                 


Asp Leu Asn Ser Ala Val Asp His His His His His His 
385                 390                 395         


<210>  165
<211>  292
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SopE1-105-Ink4a-MycHis

<400>  165

Val Thr Lys Ile Thr Leu Ser Pro Gln Asn Phe Arg Ile Gln Lys Gln 
1               5                   10                  15      


Glu Thr Thr Leu Leu Lys Glu Lys Ser Thr Glu Lys Asn Ser Leu Ala 
            20                  25                  30          


Lys Ser Ile Leu Ala Val Lys Asn His Phe Ile Glu Leu Arg Ser Lys 
        35                  40                  45              


Leu Ser Glu Arg Phe Ile Ser His Lys Asn Thr Glu Ser Ser Ala Thr 
    50                  55                  60                  


His Phe His Arg Gly Ser Ala Ser Glu Gly Arg Ala Val Leu Thr Asn 
65                  70                  75                  80  


Lys Val Val Lys Asp Phe Met Leu Gln Thr Leu Asn Asp Ile Asp Ile 
                85                  90                  95      


Arg Gly Ser Ala Ser Lys Asp Pro Ala Gly Thr Ile Trp Glu Phe Met 
            100                 105                 110         


Glu Pro Ala Ala Gly Ser Ser Met Glu Pro Ser Ala Asp Trp Leu Ala 
        115                 120                 125             


Thr Ala Ala Ala Arg Gly Arg Val Glu Glu Val Arg Ala Leu Leu Glu 
    130                 135                 140                 


Ala Gly Ala Leu Pro Asn Ala Pro Asn Ser Tyr Gly Arg Arg Pro Ile 
145                 150                 155                 160 


Gln Val Met Met Met Gly Ser Ala Arg Val Ala Glu Leu Leu Leu Leu 
                165                 170                 175     


His Gly Ala Glu Pro Asn Cys Ala Asp Pro Ala Thr Leu Thr Arg Pro 
            180                 185                 190         


Val His Asp Ala Ala Arg Glu Gly Phe Leu Asp Thr Leu Val Val Leu 
        195                 200                 205             


His Arg Ala Gly Ala Arg Leu Asp Val Arg Asp Ala Trp Gly Arg Leu 
    210                 215                 220                 


Pro Val Asp Leu Ala Glu Glu Leu Gly His Arg Asp Val Ala Arg Tyr 
225                 230                 235                 240 


Leu Arg Ala Ala Ala Gly Gly Thr Arg Gly Ser Asn His Ala Arg Ile 
                245                 250                 255     


Asp Ala Ala Glu Gly Pro Ser Asp Ile Pro Asp Lys Leu Gly Pro Glu 
            260                 265                 270         


Gln Lys Leu Ile Ser Glu Glu Asp Leu Asn Ser Ala Val Asp His His 
        275                 280                 285             


His His His His 
    290         


<210>  166
<211>  409
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SteA-Ink4c-MycHis

<400>  166

Met Pro Tyr Thr Ser Val Ser Thr Tyr Ala Arg Ala Leu Ser Gly Asn 
1               5                   10                  15      


Lys Leu Pro His Val Ala Ala Gly Asp Tyr Glu Asn Lys Leu Ser Thr 
            20                  25                  30          


Lys Ile Met Lys Gly Ile Leu Tyr Val Leu Thr Ala Gly Leu Ala Tyr 
        35                  40                  45              


Gly Phe Thr Arg Val Ile Glu His Tyr Cys Asn Val Thr Pro Lys Val 
    50                  55                  60                  


Ala Glu Phe Cys Ala Asn Ala Gly Asn Ile His Asn His Leu Ala Asp 
65                  70                  75                  80  


Ala Val Arg Asp Gly Leu Phe Thr Ile Asp Val Glu Leu Ser Asp Gly 
                85                  90                  95      


Arg Met Leu Thr Phe Glu Gln Leu Ser Leu Ile Ala Glu Gly Lys Pro 
            100                 105                 110         


Ile Val Arg Ile Ser Asp Gly Glu His Thr Val Glu Val Glu Gly Thr 
        115                 120                 125             


Phe Glu Glu Ile Cys Met Arg Leu Glu Glu Gly Phe Phe Glu Ala Pro 
    130                 135                 140                 


Ala Tyr Tyr Asp Tyr Asp Ile Asp Glu Lys Tyr Lys Thr Val Arg Glu 
145                 150                 155                 160 


Arg Met Ala Ala Tyr Asn Ala Leu Pro Gln Ala Leu Gly Ala Ile Pro 
                165                 170                 175     


Cys Leu Glu Tyr Tyr Ile Ala Arg Ala Ser Asn Met Gln Glu Ala Lys 
            180                 185                 190         


Ala Gln Trp Ala Ala Asp Ile Lys Ala Arg Tyr His Asn Tyr Leu Asp 
        195                 200                 205             


Asn Tyr Gly Thr Ile Trp Glu Phe Met Ala Glu Pro Trp Gly Asn Glu 
    210                 215                 220                 


Leu Ala Ser Ala Ala Ala Arg Gly Asp Leu Glu Gln Leu Thr Ser Leu 
225                 230                 235                 240 


Leu Gln Asn Asn Val Asn Val Asn Ala Gln Asn Gly Phe Gly Arg Thr 
                245                 250                 255     


Ala Leu Gln Val Met Lys Leu Gly Asn Pro Glu Ile Ala Arg Arg Leu 
            260                 265                 270         


Leu Leu Arg Gly Ala Asn Pro Asp Leu Lys Asp Arg Thr Gly Phe Ala 
        275                 280                 285             


Val Ile His Asp Ala Ala Arg Ala Gly Phe Leu Asp Thr Leu Gln Thr 
    290                 295                 300                 


Leu Leu Glu Phe Gln Ala Asp Val Asn Ile Glu Asp Asn Glu Gly Asn 
305                 310                 315                 320 


Leu Pro Leu His Leu Ala Ala Lys Glu Gly His Leu Arg Val Val Glu 
                325                 330                 335     


Phe Leu Val Lys His Thr Ala Ser Asn Val Gly His Arg Asn His Lys 
            340                 345                 350         


Gly Asp Thr Ala Cys Asp Leu Ala Arg Leu Tyr Gly Arg Asn Glu Val 
        355                 360                 365             


Val Ser Leu Met Gln Ala Asn Gly Ala Gly Gly Ala Thr Asn Leu Gln 
    370                 375                 380                 


Lys Leu Gly Pro Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Asn Ser 
385                 390                 395                 400 


Ala Val Asp His His His His His His 
                405                 


<210>  167
<211>  304
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SopE1-105-Ink4c-MycHis

<400>  167

Val Thr Lys Ile Thr Leu Ser Pro Gln Asn Phe Arg Ile Gln Lys Gln 
1               5                   10                  15      


Glu Thr Thr Leu Leu Lys Glu Lys Ser Thr Glu Lys Asn Ser Leu Ala 
            20                  25                  30          


Lys Ser Ile Leu Ala Val Lys Asn His Phe Ile Glu Leu Arg Ser Lys 
        35                  40                  45              


Leu Ser Glu Arg Phe Ile Ser His Lys Asn Thr Glu Ser Ser Ala Thr 
    50                  55                  60                  


His Phe His Arg Gly Ser Ala Ser Glu Gly Arg Ala Val Leu Thr Asn 
65                  70                  75                  80  


Lys Val Val Lys Asp Phe Met Leu Gln Thr Leu Asn Asp Ile Asp Ile 
                85                  90                  95      


Arg Gly Ser Ala Ser Lys Asp Pro Ala Gly Thr Ile Trp Glu Phe Met 
            100                 105                 110         


Ala Glu Pro Trp Gly Asn Glu Leu Ala Ser Ala Ala Ala Arg Gly Asp 
        115                 120                 125             


Leu Glu Gln Leu Thr Ser Leu Leu Gln Asn Asn Val Asn Val Asn Ala 
    130                 135                 140                 


Gln Asn Gly Phe Gly Arg Thr Ala Leu Gln Val Met Lys Leu Gly Asn 
145                 150                 155                 160 


Pro Glu Ile Ala Arg Arg Leu Leu Leu Arg Gly Ala Asn Pro Asp Leu 
                165                 170                 175     


Lys Asp Arg Thr Gly Phe Ala Val Ile His Asp Ala Ala Arg Ala Gly 
            180                 185                 190         


Phe Leu Asp Thr Leu Gln Thr Leu Leu Glu Phe Gln Ala Asp Val Asn 
        195                 200                 205             


Ile Glu Asp Asn Glu Gly Asn Leu Pro Leu His Leu Ala Ala Lys Glu 
    210                 215                 220                 


Gly His Leu Arg Val Val Glu Phe Leu Val Lys His Thr Ala Ser Asn 
225                 230                 235                 240 


Val Gly His Arg Asn His Lys Gly Asp Thr Ala Cys Asp Leu Ala Arg 
                245                 250                 255     


Leu Tyr Gly Arg Asn Glu Val Val Ser Leu Met Gln Ala Asn Gly Ala 
            260                 265                 270         


Gly Gly Ala Thr Asn Leu Gln Lys Leu Gly Pro Glu Gln Lys Leu Ile 
        275                 280                 285             


Ser Glu Glu Asp Leu Asn Ser Ala Val Asp His His His His His His 
    290                 295                 300                 


<210>  168
<211>  446
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SteA-Mad2-MycHis

<400>  168

Met Pro Tyr Thr Ser Val Ser Thr Tyr Ala Arg Ala Leu Ser Gly Asn 
1               5                   10                  15      


Lys Leu Pro His Val Ala Ala Gly Asp Tyr Glu Asn Lys Leu Ser Thr 
            20                  25                  30          


Lys Ile Met Lys Gly Ile Leu Tyr Val Leu Thr Ala Gly Leu Ala Tyr 
        35                  40                  45              


Gly Phe Thr Arg Val Ile Glu His Tyr Cys Asn Val Thr Pro Lys Val 
    50                  55                  60                  


Ala Glu Phe Cys Ala Asn Ala Gly Asn Ile His Asn His Leu Ala Asp 
65                  70                  75                  80  


Ala Val Arg Asp Gly Leu Phe Thr Ile Asp Val Glu Leu Ser Asp Gly 
                85                  90                  95      


Arg Met Leu Thr Phe Glu Gln Leu Ser Leu Ile Ala Glu Gly Lys Pro 
            100                 105                 110         


Ile Val Arg Ile Ser Asp Gly Glu His Thr Val Glu Val Glu Gly Thr 
        115                 120                 125             


Phe Glu Glu Ile Cys Met Arg Leu Glu Glu Gly Phe Phe Glu Ala Pro 
    130                 135                 140                 


Ala Tyr Tyr Asp Tyr Asp Ile Asp Glu Lys Tyr Lys Thr Val Arg Glu 
145                 150                 155                 160 


Arg Met Ala Ala Tyr Asn Ala Leu Pro Gln Ala Leu Gly Ala Ile Pro 
                165                 170                 175     


Cys Leu Glu Tyr Tyr Ile Ala Arg Ala Ser Asn Met Gln Glu Ala Lys 
            180                 185                 190         


Ala Gln Trp Ala Ala Asp Ile Lys Ala Arg Tyr His Asn Tyr Leu Asp 
        195                 200                 205             


Asn Tyr Gly Thr Ile Trp Glu Phe Met Ala Leu Gln Leu Ser Arg Glu 
    210                 215                 220                 


Gln Gly Ile Thr Leu Arg Gly Ser Ala Glu Ile Val Ala Glu Phe Phe 
225                 230                 235                 240 


Ser Phe Gly Ile Asn Ser Ile Leu Tyr Gln Arg Gly Ile Tyr Pro Ser 
                245                 250                 255     


Glu Thr Phe Thr Arg Val Gln Lys Tyr Gly Leu Thr Leu Leu Val Thr 
            260                 265                 270         


Thr Asp Leu Glu Leu Ile Lys Tyr Leu Asn Asn Val Val Glu Gln Leu 
        275                 280                 285             


Lys Asp Trp Leu Tyr Lys Cys Ser Val Gln Lys Leu Val Val Val Ile 
    290                 295                 300                 


Ser Asn Ile Glu Ser Gly Glu Val Leu Glu Arg Trp Gln Phe Asp Ile 
305                 310                 315                 320 


Glu Cys Asp Lys Thr Ala Lys Asp Asp Ser Ala Pro Arg Glu Lys Ser 
                325                 330                 335     


Gln Lys Ala Ile Gln Asp Glu Ile Arg Ser Val Ile Arg Gln Ile Thr 
            340                 345                 350         


Ala Thr Val Thr Phe Leu Pro Leu Leu Glu Val Ser Cys Ser Phe Asp 
        355                 360                 365             


Leu Leu Ile Tyr Thr Asp Lys Asp Leu Val Val Pro Glu Lys Trp Glu 
    370                 375                 380                 


Glu Ser Gly Pro Gln Phe Ile Thr Asn Ser Glu Glu Val Arg Leu Arg 
385                 390                 395                 400 


Ser Phe Thr Thr Thr Ile His Lys Val Asn Ser Met Val Ala Tyr Lys 
                405                 410                 415     


Ile Pro Val Asn Asp Lys Leu Gly Pro Glu Gln Lys Leu Ile Ser Glu 
            420                 425                 430         


Glu Asp Leu Asn Ser Ala Val Asp His His His His His His 
        435                 440                 445     


<210>  169
<211>  341
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SopE1-105-Mad2-MycHis

<400>  169

Val Thr Lys Ile Thr Leu Ser Pro Gln Asn Phe Arg Ile Gln Lys Gln 
1               5                   10                  15      


Glu Thr Thr Leu Leu Lys Glu Lys Ser Thr Glu Lys Asn Ser Leu Ala 
            20                  25                  30          


Lys Ser Ile Leu Ala Val Lys Asn His Phe Ile Glu Leu Arg Ser Lys 
        35                  40                  45              


Leu Ser Glu Arg Phe Ile Ser His Lys Asn Thr Glu Ser Ser Ala Thr 
    50                  55                  60                  


His Phe His Arg Gly Ser Ala Ser Glu Gly Arg Ala Val Leu Thr Asn 
65                  70                  75                  80  


Lys Val Val Lys Asp Phe Met Leu Gln Thr Leu Asn Asp Ile Asp Ile 
                85                  90                  95      


Arg Gly Ser Ala Ser Lys Asp Pro Ala Gly Thr Ile Trp Glu Phe Met 
            100                 105                 110         


Ala Leu Gln Leu Ser Arg Glu Gln Gly Ile Thr Leu Arg Gly Ser Ala 
        115                 120                 125             


Glu Ile Val Ala Glu Phe Phe Ser Phe Gly Ile Asn Ser Ile Leu Tyr 
    130                 135                 140                 


Gln Arg Gly Ile Tyr Pro Ser Glu Thr Phe Thr Arg Val Gln Lys Tyr 
145                 150                 155                 160 


Gly Leu Thr Leu Leu Val Thr Thr Asp Leu Glu Leu Ile Lys Tyr Leu 
                165                 170                 175     


Asn Asn Val Val Glu Gln Leu Lys Asp Trp Leu Tyr Lys Cys Ser Val 
            180                 185                 190         


Gln Lys Leu Val Val Val Ile Ser Asn Ile Glu Ser Gly Glu Val Leu 
        195                 200                 205             


Glu Arg Trp Gln Phe Asp Ile Glu Cys Asp Lys Thr Ala Lys Asp Asp 
    210                 215                 220                 


Ser Ala Pro Arg Glu Lys Ser Gln Lys Ala Ile Gln Asp Glu Ile Arg 
225                 230                 235                 240 


Ser Val Ile Arg Gln Ile Thr Ala Thr Val Thr Phe Leu Pro Leu Leu 
                245                 250                 255     


Glu Val Ser Cys Ser Phe Asp Leu Leu Ile Tyr Thr Asp Lys Asp Leu 
            260                 265                 270         


Val Val Pro Glu Lys Trp Glu Glu Ser Gly Pro Gln Phe Ile Thr Asn 
        275                 280                 285             


Ser Glu Glu Val Arg Leu Arg Ser Phe Thr Thr Thr Ile His Lys Val 
    290                 295                 300                 


Asn Ser Met Val Ala Tyr Lys Ile Pro Val Asn Asp Lys Leu Gly Pro 
305                 310                 315                 320 


Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Asn Ser Ala Val Asp His 
                325                 330                 335     


His His His His His 
            340     


<210>  170
<211>  538
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SteA-Cdk1-MycHis

<400>  170

Met Pro Tyr Thr Ser Val Ser Thr Tyr Ala Arg Ala Leu Ser Gly Asn 
1               5                   10                  15      


Lys Leu Pro His Val Ala Ala Gly Asp Tyr Glu Asn Lys Leu Ser Thr 
            20                  25                  30          


Lys Ile Met Lys Gly Ile Leu Tyr Val Leu Thr Ala Gly Leu Ala Tyr 
        35                  40                  45              


Gly Phe Thr Arg Val Ile Glu His Tyr Cys Asn Val Thr Pro Lys Val 
    50                  55                  60                  


Ala Glu Phe Cys Ala Asn Ala Gly Asn Ile His Asn His Leu Ala Asp 
65                  70                  75                  80  


Ala Val Arg Asp Gly Leu Phe Thr Ile Asp Val Glu Leu Ser Asp Gly 
                85                  90                  95      


Arg Met Leu Thr Phe Glu Gln Leu Ser Leu Ile Ala Glu Gly Lys Pro 
            100                 105                 110         


Ile Val Arg Ile Ser Asp Gly Glu His Thr Val Glu Val Glu Gly Thr 
        115                 120                 125             


Phe Glu Glu Ile Cys Met Arg Leu Glu Glu Gly Phe Phe Glu Ala Pro 
    130                 135                 140                 


Ala Tyr Tyr Asp Tyr Asp Ile Asp Glu Lys Tyr Lys Thr Val Arg Glu 
145                 150                 155                 160 


Arg Met Ala Ala Tyr Asn Ala Leu Pro Gln Ala Leu Gly Ala Ile Pro 
                165                 170                 175     


Cys Leu Glu Tyr Tyr Ile Ala Arg Ala Ser Asn Met Gln Glu Ala Lys 
            180                 185                 190         


Ala Gln Trp Ala Ala Asp Ile Lys Ala Arg Tyr His Asn Tyr Leu Asp 
        195                 200                 205             


Asn Tyr Gly Thr Ile Trp Glu Phe Met Glu Asp Tyr Thr Lys Ile Glu 
    210                 215                 220                 


Lys Ile Gly Glu Gly Thr Tyr Gly Val Val Tyr Lys Gly Arg His Lys 
225                 230                 235                 240 


Thr Thr Gly Gln Val Val Ala Met Lys Lys Ile Arg Leu Glu Ser Glu 
                245                 250                 255     


Glu Glu Gly Val Pro Ser Thr Ala Ile Arg Glu Ile Ser Leu Leu Lys 
            260                 265                 270         


Glu Leu Arg His Pro Asn Ile Val Ser Leu Gln Asp Val Leu Met Gln 
        275                 280                 285             


Asp Ser Arg Leu Tyr Leu Ile Phe Glu Phe Leu Ser Met Asp Leu Lys 
    290                 295                 300                 


Lys Tyr Leu Asp Ser Ile Pro Pro Gly Gln Tyr Met Asp Ser Ser Leu 
305                 310                 315                 320 


Val Lys Ser Tyr Leu Tyr Gln Ile Leu Gln Gly Ile Val Phe Cys His 
                325                 330                 335     


Ser Arg Arg Val Leu His Arg Asp Leu Lys Pro Gln Asn Leu Leu Ile 
            340                 345                 350         


Asp Asp Lys Gly Thr Ile Lys Leu Ala Asp Phe Gly Leu Ala Arg Ala 
        355                 360                 365             


Phe Gly Ile Pro Ile Arg Val Tyr Thr His Glu Val Val Thr Leu Trp 
    370                 375                 380                 


Tyr Arg Ser Pro Glu Val Leu Leu Gly Ser Ala Arg Tyr Ser Thr Pro 
385                 390                 395                 400 


Val Asp Ile Trp Ser Ile Gly Thr Ile Phe Ala Glu Leu Ala Thr Lys 
                405                 410                 415     


Lys Pro Leu Phe His Gly Asp Ser Glu Ile Asp Gln Leu Phe Arg Ile 
            420                 425                 430         


Phe Arg Ala Leu Gly Thr Pro Asn Asn Glu Val Trp Pro Glu Val Glu 
        435                 440                 445             


Ser Leu Gln Asp Tyr Lys Asn Thr Phe Pro Lys Trp Lys Pro Gly Ser 
    450                 455                 460                 


Leu Ala Ser His Val Lys Asn Leu Asp Glu Asn Gly Leu Asp Leu Leu 
465                 470                 475                 480 


Ser Lys Met Leu Ile Tyr Asp Pro Ala Lys Arg Ile Ser Gly Lys Met 
                485                 490                 495     


Ala Leu Asn His Pro Tyr Phe Asn Asp Leu Asp Asn Gln Ile Lys Lys 
            500                 505                 510         


Met Lys Leu Gly Pro Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Asn 
        515                 520                 525             


Ser Ala Val Asp His His His His His His 
    530                 535             


<210>  171
<211>  433
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SopE1-105-Cdk1-MycHis

<400>  171

Val Thr Lys Ile Thr Leu Ser Pro Gln Asn Phe Arg Ile Gln Lys Gln 
1               5                   10                  15      


Glu Thr Thr Leu Leu Lys Glu Lys Ser Thr Glu Lys Asn Ser Leu Ala 
            20                  25                  30          


Lys Ser Ile Leu Ala Val Lys Asn His Phe Ile Glu Leu Arg Ser Lys 
        35                  40                  45              


Leu Ser Glu Arg Phe Ile Ser His Lys Asn Thr Glu Ser Ser Ala Thr 
    50                  55                  60                  


His Phe His Arg Gly Ser Ala Ser Glu Gly Arg Ala Val Leu Thr Asn 
65                  70                  75                  80  


Lys Val Val Lys Asp Phe Met Leu Gln Thr Leu Asn Asp Ile Asp Ile 
                85                  90                  95      


Arg Gly Ser Ala Ser Lys Asp Pro Ala Gly Thr Ile Trp Glu Phe Met 
            100                 105                 110         


Glu Asp Tyr Thr Lys Ile Glu Lys Ile Gly Glu Gly Thr Tyr Gly Val 
        115                 120                 125             


Val Tyr Lys Gly Arg His Lys Thr Thr Gly Gln Val Val Ala Met Lys 
    130                 135                 140                 


Lys Ile Arg Leu Glu Ser Glu Glu Glu Gly Val Pro Ser Thr Ala Ile 
145                 150                 155                 160 


Arg Glu Ile Ser Leu Leu Lys Glu Leu Arg His Pro Asn Ile Val Ser 
                165                 170                 175     


Leu Gln Asp Val Leu Met Gln Asp Ser Arg Leu Tyr Leu Ile Phe Glu 
            180                 185                 190         


Phe Leu Ser Met Asp Leu Lys Lys Tyr Leu Asp Ser Ile Pro Pro Gly 
        195                 200                 205             


Gln Tyr Met Asp Ser Ser Leu Val Lys Ser Tyr Leu Tyr Gln Ile Leu 
    210                 215                 220                 


Gln Gly Ile Val Phe Cys His Ser Arg Arg Val Leu His Arg Asp Leu 
225                 230                 235                 240 


Lys Pro Gln Asn Leu Leu Ile Asp Asp Lys Gly Thr Ile Lys Leu Ala 
                245                 250                 255     


Asp Phe Gly Leu Ala Arg Ala Phe Gly Ile Pro Ile Arg Val Tyr Thr 
            260                 265                 270         


His Glu Val Val Thr Leu Trp Tyr Arg Ser Pro Glu Val Leu Leu Gly 
        275                 280                 285             


Ser Ala Arg Tyr Ser Thr Pro Val Asp Ile Trp Ser Ile Gly Thr Ile 
    290                 295                 300                 


Phe Ala Glu Leu Ala Thr Lys Lys Pro Leu Phe His Gly Asp Ser Glu 
305                 310                 315                 320 


Ile Asp Gln Leu Phe Arg Ile Phe Arg Ala Leu Gly Thr Pro Asn Asn 
                325                 330                 335     


Glu Val Trp Pro Glu Val Glu Ser Leu Gln Asp Tyr Lys Asn Thr Phe 
            340                 345                 350         


Pro Lys Trp Lys Pro Gly Ser Leu Ala Ser His Val Lys Asn Leu Asp 
        355                 360                 365             


Glu Asn Gly Leu Asp Leu Leu Ser Lys Met Leu Ile Tyr Asp Pro Ala 
    370                 375                 380                 


Lys Arg Ile Ser Gly Lys Met Ala Leu Asn His Pro Tyr Phe Asn Asp 
385                 390                 395                 400 


Leu Asp Asn Gln Ile Lys Lys Met Lys Leu Gly Pro Glu Gln Lys Leu 
                405                 410                 415     


Ile Ser Glu Glu Asp Leu Asn Ser Ala Val Asp His His His His His 
            420                 425                 430         


His 
    


<210>  172
<211>  95
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer No. : Si_745

<400>  172
catgctcgag ggtgccatcg atgatgccgc ccgcgaaggt tttctggata ccctggtggt       60

gctgcatcgc gccggtgccc gctaattcga acatg                                  95


<210>  173
<211>  95
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer No. : Si_746

<400>  173
catgttcgaa ttagcgggca ccggcgcgat gcagcaccac cagggtatcc agaaaacctt       60

cgcgggcggc atcatcgatg gcaccctcga gcatg                                  95


<210>  174
<211>  95
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer No. : Si_747

<400>  174
catgctcgag ggtgccatcg attatggtcg caaaaaacgc cgccaacgcc gccgcggtcc       60

ggtgaaacgc cgcctgtttg gttaattcga acatg                                  95


<210>  175
<211>  95
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer No. : Si_748

<400>  175
catgttcgaa ttaaccaaac aggcggcgtt tcaccggacc gcggcggcgt tggcggcgtt       60

ttttgcgacc ataatcgatg gcaccctcga gcatg                                  95


<210>  176
<211>  95
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer No. : Si_749

<400>  176
catgctcgag ggtgccatcg ataaacgccg ccaaaccagc atgaccgcct tttatcatag       60

caaacgccgc ctgattttta gctaattcga acatg                                  95


<210>  177
<211>  95
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer No. : Si_750

<400>  177
catgttcgaa ttagctaaaa atcaggcggc gtttgctatg ataaaaggcg gtcatgctgg       60

tttggcggcg tttatcgatg gcaccctcga gcatg                                  95


<210>  178
<211>  83
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer No. : Si_753

<400>  178
catgctcgag ggtgccatcg ataccagcat gaccgccttt tatcatagca aacgccgcct       60

gatttttagc taattcgaac atg                                               83


<210>  179
<211>  83
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer No. : Si_754

<400>  179
catgttcgaa ttagctaaaa atcaggcggc gtttgctatg ataaaaggcg gtcatgctgg       60

tatcgatggc accctcgagc atg                                               83


<210>  180
<211>  86
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer No. : Si_755

<400>  180
catgctcgag ggtgccatcg atgcctgtcg ccgcctgttt ggtccggtgg atagcgaaca       60

actgagccgc gattaattcg aacatg                                            86


<210>  181
<211>  86
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer No. : Si_756

<400>  181
catgttcgaa ttaatcgcgg ctcagttgtt cgctatccac cggaccaaac aggcggcgac       60

aggcatcgat ggcaccctcg agcatg                                            86


<210>  182
<211>  62
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer No. : Si_757

<400>  182
catgctcgag ggtgccatcg attgggaact ggtggtgctg ggtaaactgt aattcgaaca       60

tg                                                                      62


<210>  183
<211>  62
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer No. : Si_758

<400>  183
catgttcgaa ttacagttta cccagcacca ccagttccca atcgatggca ccctcgagca       60

tg                                                                      62


<210>  184
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer No. : Si_703

<400>  184
gacatggaat tcatggagcc ggcggcg                                           27


<210>  185
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer No. : Si_704

<400>  185
catgaagctt atcggggatg tctgaggg                                          28


<210>  186
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer No. : Si_705

<400>  186
gacatggaat tcatggccga gccttgggg                                         29


<210>  187
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer No. : Si_706

<400>  187
gttaacatca gcttgaaact ccagcaaagt ctgtaaagtg tccaggaaac c                51


<210>  188
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer No. : Si_707

<400>  188
ggtttcctgg acactttaca gactttgctg gagtttcaag ctgatgttaa c                51


<210>  189
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer No. : Si_708

<400>  189
catgaagctt ttgaagattt gtggctcccc                                        30


<210>  190
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer No. : Si_709

<400>  190
gacatggaat tcatggcgct gcagctctcc                                        30


<210>  191
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer No. : Si_710

<400>  191
catgaagctt gtcattgaca ggaattttgt agg                                    33


<210>  192
<211>  38
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer No. : Si_711

<400>  192
gacatggaat tcatggaaga ttataccaaa atagagaa                               38


<210>  193
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer No. : Si_712

<400>  193
catgaagctt catcttctta atctgattgt ccaa                                   34


<210>  194
<211>  276
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YopE1-138-Y. enterocolitica codon optimized murine tBid

<400>  194

Met Lys Ile Ser Ser Phe Ile Ser Thr Ser Leu Pro Leu Pro Ala Ser 
1               5                   10                  15      


Val Ser Gly Ser Ser Ser Val Gly Glu Met Ser Gly Arg Ser Val Ser 
            20                  25                  30          


Gln Gln Lys Ser Asp Gln Tyr Ala Asn Asn Leu Ala Gly Arg Thr Glu 
        35                  40                  45              


Ser Pro Gln Gly Ser Ser Leu Ala Ser Arg Ile Ile Glu Arg Leu Ser 
    50                  55                  60                  


Ser Met Ala His Ser Val Ile Gly Phe Ile Gln Arg Met Phe Ser Glu 
65                  70                  75                  80  


Gly Ser His Lys Pro Val Val Thr Pro Ala Leu Thr Pro Ala Gln Met 
                85                  90                  95      


Pro Ser Pro Thr Ser Phe Ser Asp Ser Ile Lys Gln Leu Ala Ala Glu 
            100                 105                 110         


Thr Leu Pro Lys Tyr Met Gln Gln Leu Ser Ser Leu Asp Ala Glu Thr 
        115                 120                 125             


Leu Gln Lys Asn His Asp Gln Phe Ala Thr Leu Glu Gly Ser Gln Ala 
    130                 135                 140                 


Ser Arg Ser Phe Asn Gln Gly Arg Ile Glu Pro Asp Ser Glu Ser Gln 
145                 150                 155                 160 


Glu Glu Ile Ile His Asn Ile Ala Arg His Leu Ala Gln Ile Gly Asp 
                165                 170                 175     


Glu Met Asp His Asn Ile Gln Pro Thr Leu Val Arg Gln Leu Ala Ala 
            180                 185                 190         


Gln Phe Met Asn Gly Ser Leu Ser Glu Glu Asp Lys Arg Asn Cys Leu 
        195                 200                 205             


Ala Lys Ala Leu Asp Glu Val Lys Thr Ala Phe Pro Arg Asp Met Glu 
    210                 215                 220                 


Asn Asp Lys Ala Met Leu Ile Met Thr Met Leu Leu Ala Lys Lys Val 
225                 230                 235                 240 


Ala Ser His Ala Pro Ser Leu Leu Arg Asp Val Phe His Thr Thr Val 
                245                 250                 255     


Asn Phe Ile Asn Gln Asn Leu Phe Ser Tyr Val Arg Asn Leu Val Arg 
            260                 265                 270         


Asn Glu Met Asp 
        275     


<210>  195
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YopE1-138-Ubiquitin

<400>  195

Met Lys Ile Ser Ser Phe Ile Ser Thr Ser Leu Pro Leu Pro Ala Ser 
1               5                   10                  15      


Val Ser Gly Ser Ser Ser Val Gly Glu Met Ser Gly Arg Ser Val Ser 
            20                  25                  30          


Gln Gln Lys Ser Asp Gln Tyr Ala Asn Asn Leu Ala Gly Arg Thr Glu 
        35                  40                  45              


Ser Pro Gln Gly Ser Ser Leu Ala Ser Arg Ile Ile Glu Arg Leu Ser 
    50                  55                  60                  


Ser Met Ala His Ser Val Ile Gly Phe Ile Gln Arg Met Phe Ser Glu 
65                  70                  75                  80  


Gly Ser His Lys Pro Val Val Thr Pro Ala Leu Thr Pro Ala Gln Met 
                85                  90                  95      


Pro Ser Pro Thr Ser Phe Ser Asp Ser Ile Lys Gln Leu Ala Ala Glu 
            100                 105                 110         


Thr Leu Pro Lys Tyr Met Gln Gln Leu Ser Ser Leu Asp Ala Glu Thr 
        115                 120                 125             


Leu Gln Lys Asn His Asp Gln Phe Ala Thr Leu Glu Met Gln Ile Phe 
    130                 135                 140                 


Val Lys Thr Leu Thr Gly Lys Thr Ile Thr Leu Glu Val Glu Pro Ser 
145                 150                 155                 160 


Asp Thr Ile Glu Asn Val Lys Ala Lys Ile Gln Asp Lys Glu Gly Ile 
                165                 170                 175     


Pro Pro Asp Gln Gln Arg Leu Ile Phe Ala Gly Lys Gln Leu Glu Asp 
            180                 185                 190         


Gly Arg Thr Leu Ser Asp Tyr Asn Ile Gln Lys Glu Ser Thr Leu His 
        195                 200                 205             


Leu Val Leu Arg Leu Arg Gly Gly Phe Glu Ala Ser Lys Leu Gly Pro 
    210                 215                 220                 


Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Asn Ser Ala Val Asp His 
225                 230                 235                 240 


His His His His His 
                245 


<210>  196
<211>  419
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YopE1-138-Ubiquitin-Flag-INK4C-MycHis

<400>  196

Met Lys Ile Ser Ser Phe Ile Ser Thr Ser Leu Pro Leu Pro Ala Ser 
1               5                   10                  15      


Val Ser Gly Ser Ser Ser Val Gly Glu Met Ser Gly Arg Ser Val Ser 
            20                  25                  30          


Gln Gln Lys Ser Asp Gln Tyr Ala Asn Asn Leu Ala Gly Arg Thr Glu 
        35                  40                  45              


Ser Pro Gln Gly Ser Ser Leu Ala Ser Arg Ile Ile Glu Arg Leu Ser 
    50                  55                  60                  


Ser Met Ala His Ser Val Ile Gly Phe Ile Gln Arg Met Phe Ser Glu 
65                  70                  75                  80  


Gly Ser His Lys Pro Val Val Thr Pro Ala Leu Thr Pro Ala Gln Met 
                85                  90                  95      


Pro Ser Pro Thr Ser Phe Ser Asp Ser Ile Lys Gln Leu Ala Ala Glu 
            100                 105                 110         


Thr Leu Pro Lys Tyr Met Gln Gln Leu Ser Ser Leu Asp Ala Glu Thr 
        115                 120                 125             


Leu Gln Lys Asn His Asp Gln Phe Ala Thr Leu Glu Met Gln Ile Phe 
    130                 135                 140                 


Val Lys Thr Leu Thr Gly Lys Thr Ile Thr Leu Glu Val Glu Pro Ser 
145                 150                 155                 160 


Asp Thr Ile Glu Asn Val Lys Ala Lys Ile Gln Asp Lys Glu Gly Ile 
                165                 170                 175     


Pro Pro Asp Gln Gln Arg Leu Ile Phe Ala Gly Lys Gln Leu Glu Asp 
            180                 185                 190         


Gly Arg Thr Leu Ser Asp Tyr Asn Ile Gln Lys Glu Ser Thr Leu His 
        195                 200                 205             


Leu Val Leu Arg Leu Arg Gly Gly Phe Glu Asp Tyr Lys Asp Asp Asp 
    210                 215                 220                 


Asp Lys Met Ala Glu Pro Trp Gly Asn Glu Leu Ala Ser Ala Ala Ala 
225                 230                 235                 240 


Arg Gly Asp Leu Glu Gln Leu Thr Ser Leu Leu Gln Asn Asn Val Asn 
                245                 250                 255     


Val Asn Ala Gln Asn Gly Phe Gly Arg Thr Ala Leu Gln Val Met Lys 
            260                 265                 270         


Leu Gly Asn Pro Glu Ile Ala Arg Arg Leu Leu Leu Arg Gly Ala Asn 
        275                 280                 285             


Pro Asp Leu Lys Asp Arg Thr Gly Phe Ala Val Ile His Asp Ala Ala 
    290                 295                 300                 


Arg Ala Gly Phe Leu Asp Thr Leu Gln Ala Leu Pro Glu Phe Gln Ala 
305                 310                 315                 320 


Asp Val Asn Ile Glu Asp Asn Glu Gly Asn Leu Pro Leu His Leu Ala 
                325                 330                 335     


Ala Lys Glu Gly His Leu Arg Val Val Glu Phe Leu Val Lys His Thr 
            340                 345                 350         


Ala Ser Asn Val Gly His Arg Asn His Lys Gly Asp Thr Ala Cys Asp 
        355                 360                 365             


Leu Ala Arg Leu Tyr Gly Arg Asn Glu Val Val Ser Leu Met Gln Ala 
    370                 375                 380                 


Asn Gly Ala Gly Gly Ala Thr Asn Leu Gln Lys Leu Gly Pro Glu Gln 
385                 390                 395                 400 


Lys Leu Ile Ser Glu Glu Asp Leu Asn Ser Ala Val Asp His His His 
                405                 410                 415     


His His His 
            


<210>  197
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer No. : Si_585

<400>  197
cagtctcgag atgcagatct tcgtcaagac                                        30


<210>  198
<211>  43
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer No. : Si_586

<400>  198
gttaaagctt gctagcttcg aaaccaccac gtagacgtaa gac                         43


<210>  199
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer No. : Si_588

<400>  199
cagtttcgaa gattataaag atgatgatga taaaatggcc gagccttg                    48


<210>  200
<211>  165
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YopE1-138 - Y. enterocolitica codon optimized murine BID BH3 part

<400>  200

Met Lys Ile Ser Ser Phe Ile Ser Thr Ser Leu Pro Leu Pro Ala Ser 
1               5                   10                  15      


Val Ser Gly Ser Ser Ser Val Gly Glu Met Ser Gly Arg Ser Val Ser 
            20                  25                  30          


Gln Gln Lys Ser Asp Gln Tyr Ala Asn Asn Leu Ala Gly Arg Thr Glu 
        35                  40                  45              


Ser Pro Gln Gly Ser Ser Leu Ala Ser Arg Ile Ile Glu Arg Leu Ser 
    50                  55                  60                  


Ser Met Ala His Ser Val Ile Gly Phe Ile Gln Arg Met Phe Ser Glu 
65                  70                  75                  80  


Gly Ser His Lys Pro Val Val Thr Pro Ala Leu Thr Pro Ala Gln Met 
                85                  90                  95      


Pro Ser Pro Thr Ser Phe Ser Asp Ser Ile Lys Gln Leu Ala Ala Glu 
            100                 105                 110         


Thr Leu Pro Lys Tyr Met Gln Gln Leu Ser Ser Leu Asp Ala Glu Thr 
        115                 120                 125             


Leu Gln Lys Asn His Asp Gln Phe Ala Thr Leu Glu Gly Ala Ile Asp 
    130                 135                 140                 


Ala Glu Glu Ile Ile His Asn Ile Ala Arg His Leu Ala Gln Ile Gly 
145                 150                 155                 160 


Asp Glu Met Asp His 
                165 


<210>  201
<211>  161
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YopE1-138 - Y. enterocolitica codon optimized murine Bax BH3 part

<400>  201

Met Lys Ile Ser Ser Phe Ile Ser Thr Ser Leu Pro Leu Pro Ala Ser 
1               5                   10                  15      


Val Ser Gly Ser Ser Ser Val Gly Glu Met Ser Gly Arg Ser Val Ser 
            20                  25                  30          


Gln Gln Lys Ser Asp Gln Tyr Ala Asn Asn Leu Ala Gly Arg Thr Glu 
        35                  40                  45              


Ser Pro Gln Gly Ser Ser Leu Ala Ser Arg Ile Ile Glu Arg Leu Ser 
    50                  55                  60                  


Ser Met Ala His Ser Val Ile Gly Phe Ile Gln Arg Met Phe Ser Glu 
65                  70                  75                  80  


Gly Ser His Lys Pro Val Val Thr Pro Ala Leu Thr Pro Ala Gln Met 
                85                  90                  95      


Pro Ser Pro Thr Ser Phe Ser Asp Ser Ile Lys Gln Leu Ala Ala Glu 
            100                 105                 110         


Thr Leu Pro Lys Tyr Met Gln Gln Leu Ser Ser Leu Asp Ala Glu Thr 
        115                 120                 125             


Leu Gln Lys Asn His Asp Gln Phe Ala Thr Leu Glu Gly Ala Ile Asp 
    130                 135                 140                 


Ala Lys Lys Leu Ser Glu Cys Leu Arg Arg Ile Gly Asp Glu Leu Asp 
145                 150                 155                 160 


Ser 
    


<210>  202
<211>  190
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YopE1-138 - (Y. enterocolitica codon optimized murine BID BH3 
       part) 2

<400>  202

Met Lys Ile Ser Ser Phe Ile Ser Thr Ser Leu Pro Leu Pro Ala Ser 
1               5                   10                  15      


Val Ser Gly Ser Ser Ser Val Gly Glu Met Ser Gly Arg Ser Val Ser 
            20                  25                  30          


Gln Gln Lys Ser Asp Gln Tyr Ala Asn Asn Leu Ala Gly Arg Thr Glu 
        35                  40                  45              


Ser Pro Gln Gly Ser Ser Leu Ala Ser Arg Ile Ile Glu Arg Leu Ser 
    50                  55                  60                  


Ser Met Ala His Ser Val Ile Gly Phe Ile Gln Arg Met Phe Ser Glu 
65                  70                  75                  80  


Gly Ser His Lys Pro Val Val Thr Pro Ala Leu Thr Pro Ala Gln Met 
                85                  90                  95      


Pro Ser Pro Thr Ser Phe Ser Asp Ser Ile Lys Gln Leu Ala Ala Glu 
            100                 105                 110         


Thr Leu Pro Lys Tyr Met Gln Gln Leu Ser Ser Leu Asp Ala Glu Thr 
        115                 120                 125             


Leu Gln Lys Asn His Asp Gln Phe Ala Thr Leu Glu Gly Ala Ile Asp 
    130                 135                 140                 


Ala Glu Glu Ile Ile His Asn Ile Ala Arg His Leu Ala Gln Ile Gly 
145                 150                 155                 160 


Asp Glu Met Asp His Gly Ala Phe Asp Ala Glu Glu Ile Ile His Asn 
                165                 170                 175     


Ile Ala Arg His Leu Ala Gln Ile Gly Asp Glu Met Asp His 
            180                 185                 190 


<210>  203
<211>  186
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YopE1-138 - (Y. enterocolitica codon optimized murine BID BH3 
       part)(Y. enterocolitica codon optimized murine Bax BH3 part)

<400>  203

Met Lys Ile Ser Ser Phe Ile Ser Thr Ser Leu Pro Leu Pro Ala Ser 
1               5                   10                  15      


Val Ser Gly Ser Ser Ser Val Gly Glu Met Ser Gly Arg Ser Val Ser 
            20                  25                  30          


Gln Gln Lys Ser Asp Gln Tyr Ala Asn Asn Leu Ala Gly Arg Thr Glu 
        35                  40                  45              


Ser Pro Gln Gly Ser Ser Leu Ala Ser Arg Ile Ile Glu Arg Leu Ser 
    50                  55                  60                  


Ser Met Ala His Ser Val Ile Gly Phe Ile Gln Arg Met Phe Ser Glu 
65                  70                  75                  80  


Gly Ser His Lys Pro Val Val Thr Pro Ala Leu Thr Pro Ala Gln Met 
                85                  90                  95      


Pro Ser Pro Thr Ser Phe Ser Asp Ser Ile Lys Gln Leu Ala Ala Glu 
            100                 105                 110         


Thr Leu Pro Lys Tyr Met Gln Gln Leu Ser Ser Leu Asp Ala Glu Thr 
        115                 120                 125             


Leu Gln Lys Asn His Asp Gln Phe Ala Thr Leu Glu Gly Ala Ile Asp 
    130                 135                 140                 


Ala Glu Glu Ile Ile His Asn Ile Ala Arg His Leu Ala Gln Ile Gly 
145                 150                 155                 160 


Asp Glu Met Asp His Gly Ala Phe Asp Ala Lys Lys Leu Ser Glu Cys 
                165                 170                 175     


Leu Arg Arg Ile Gly Asp Glu Leu Asp Ser 
            180                 185     


<210>  204
<211>  53
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer No. 733

<400>  204
ttactactcg agggtgccat cgatgccgaa gaaattattc ataatattgc ccg              53


<210>  205
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer No. 735

<400>  205
tactccttcg aattaatgat ccatttcatc accaatttg                              39


<210>  206
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer No. 736

<400>  206
ttactactcg agggtgccat cgatgccaaa aaactgagcg aatgtctgcg                  50


<210>  207
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer No. 738

<400>  207
tactccttcg aattagctat ccagttcatc accaatg                                37


<210>  208
<211>  43
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer No. 734

<400>  208
tactccttcg aaggcaccat gatccatttc atcaccaatt tgg                         43


<210>  209
<211>  167
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YopE1-138- codon optimized murine tBid BH3 extended part

<400>  209

Met Lys Ile Ser Ser Phe Ile Ser Thr Ser Leu Pro Leu Pro Ala Ser 
1               5                   10                  15      


Val Ser Gly Ser Ser Ser Val Gly Glu Met Ser Gly Arg Ser Val Ser 
            20                  25                  30          


Gln Gln Lys Ser Asp Gln Tyr Ala Asn Asn Leu Ala Gly Arg Thr Glu 
        35                  40                  45              


Ser Pro Gln Gly Ser Ser Leu Ala Ser Arg Ile Ile Glu Arg Leu Ser 
    50                  55                  60                  


Ser Met Ala His Ser Val Ile Gly Phe Ile Gln Arg Met Phe Ser Glu 
65                  70                  75                  80  


Gly Ser His Lys Pro Val Val Thr Pro Ala Leu Thr Pro Ala Gln Met 
                85                  90                  95      


Pro Ser Pro Thr Ser Phe Ser Asp Ser Ile Lys Gln Leu Ala Ala Glu 
            100                 105                 110         


Thr Leu Pro Lys Tyr Met Gln Gln Leu Ser Ser Leu Asp Ala Glu Thr 
        115                 120                 125             


Leu Gln Lys Asn His Asp Gln Phe Ala Thr Leu Glu Ser Arg Phe Glu 
    130                 135                 140                 


Glu Ile Ile His Asn Ile Ala Arg His Leu Ala Gln Ile Gly Asp Glu 
145                 150                 155                 160 


Met Asp His Asn Ile Gln Pro 
                165         


<210>  210
<211>  168
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YopE1-138-10 Aa linker - Y. enterocolitica codon optimized murine
       tBid BH3 part

<400>  210

Met Lys Ile Ser Ser Phe Ile Ser Thr Ser Leu Pro Leu Pro Ala Ser 
1               5                   10                  15      


Val Ser Gly Ser Ser Ser Val Gly Glu Met Ser Gly Arg Ser Val Ser 
            20                  25                  30          


Gln Gln Lys Ser Asp Gln Tyr Ala Asn Asn Leu Ala Gly Arg Thr Glu 
        35                  40                  45              


Ser Pro Gln Gly Ser Ser Leu Ala Ser Arg Ile Ile Glu Arg Leu Ser 
    50                  55                  60                  


Ser Met Ala His Ser Val Ile Gly Phe Ile Gln Arg Met Phe Ser Glu 
65                  70                  75                  80  


Gly Ser His Lys Pro Val Val Thr Pro Ala Leu Thr Pro Ala Gln Met 
                85                  90                  95      


Pro Ser Pro Thr Ser Phe Ser Asp Ser Ile Lys Gln Leu Ala Ala Glu 
            100                 105                 110         


Thr Leu Pro Lys Tyr Met Gln Gln Leu Ser Ser Leu Asp Ala Glu Thr 
        115                 120                 125             


Leu Gln Lys Asn His Asp Gln Phe Ala Thr Leu Glu Ser Arg Phe Glu 
    130                 135                 140                 


Ala Gly Gly Ala Glu Glu Ile Ile His Asn Ile Ala Arg His Leu Ala 
145                 150                 155                 160 


Gln Ile Gly Asp Glu Met Asp His 
                165             


<210>  211
<211>  186
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YopE1-(138-Y. enterocolitica codon optimized murine Bax BH3 part-
       Y. enterocolitica codon optimized murine tBid BH3 part

<400>  211

Met Lys Ile Ser Ser Phe Ile Ser Thr Ser Leu Pro Leu Pro Ala Ser 
1               5                   10                  15      


Val Ser Gly Ser Ser Ser Val Gly Glu Met Ser Gly Arg Ser Val Ser 
            20                  25                  30          


Gln Gln Lys Ser Asp Gln Tyr Ala Asn Asn Leu Ala Gly Arg Thr Glu 
        35                  40                  45              


Ser Pro Gln Gly Ser Ser Leu Ala Ser Arg Ile Ile Glu Arg Leu Ser 
    50                  55                  60                  


Ser Met Ala His Ser Val Ile Gly Phe Ile Gln Arg Met Phe Ser Glu 
65                  70                  75                  80  


Gly Ser His Lys Pro Val Val Thr Pro Ala Leu Thr Pro Ala Gln Met 
                85                  90                  95      


Pro Ser Pro Thr Ser Phe Ser Asp Ser Ile Lys Gln Leu Ala Ala Glu 
            100                 105                 110         


Thr Leu Pro Lys Tyr Met Gln Gln Leu Ser Ser Leu Asp Ala Glu Thr 
        115                 120                 125             


Leu Gln Lys Asn His Asp Gln Phe Ala Thr Leu Glu Gly Ala Ile Asp 
    130                 135                 140                 


Ala Lys Lys Leu Ser Glu Cys Leu Arg Arg Ile Gly Asp Glu Leu Asp 
145                 150                 155                 160 


Ser Gly Ala Phe Asp Ala Glu Glu Ile Ile His Asn Ile Ala Arg His 
                165                 170                 175     


Leu Ala Gln Ile Gly Asp Glu Met Asp His 
            180                 185     


<210>  212
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer No. 725

<400>  212
ttactattcg aagaaattat tcataatatt gcc                                    33


<210>  213
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer No. 726

<400>  213
tactccaagc ttacggttga atattatgat ccatttcatc accaatttgg                  50


<210>  214
<211>  49
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer No. 727

<400>  214
ttactattcg aagccggtgg tgccgaagaa attattcata atattgccc                   49


<210>  215
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer No. 728

<400>  215
tactccaagc ttaatgatcc atttcatca                                         29


<210>  216
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer No. 737

<400>  216
tactccttcg aaggcaccgc tatccagttc atcaccaatg                             40

<210>  217
<211>  20
<212>  PRT
<213>  Mus musculus

<400>  217

Glu Glu Ile Ile His Asn Ile Ala Arg His Leu Ala Gln Ile Gly Asp 
1               5                   10                  15      


Glu Met Asp His 
            20  


<210>  218
<211>  14
<212>  PRT
<213>  Mus musculus

<400>  218

Ile Ala Arg His Leu Ala Gln Ile Gly Asp Glu Met Asp His 
1               5                   10                  


<210>  219
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  219

Glu Asp Ile Ile Arg Asn Ile Ala Arg His Leu Ala Gln Val Gly Asp 
1               5                   10                  15      


Ser Met Asp Arg 
            20  


<210>  220
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  220

Ile Ala Arg His Leu Ala Gln Val Gly Asp Ser Met Asp Arg Ser 
1               5                   10                  15  


<210>  221
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  221

Lys Lys Leu Ser Glu Cys Leu Arg Arg Ile Gly Asp Glu Leu Asp Ser 
1               5                   10                  15      


Asn 
    


<210>  222
<211>  14
<212>  PRT
<213>  Mus musculus

<400>  222

Leu Ser Glu Cys Leu Arg Arg Ile Gly Asp Glu Leu Asp Ser 
1               5                   10                  


<210>  223
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  223

Lys Lys Leu Ser Glu Cys Leu Lys Arg Ile Gly Asp Glu Leu Asp Ser 
1               5                   10                  15      


Asn 
    


<210>  224
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  224

Leu Ser Glu Cys Leu Lys Arg Ile Gly Asp Glu Leu Asp Ser 
1               5                   10                  