                         SEQUENCE LISTING

<110>  The Board of Regents of the Nevada System of Higher 
       Education on Behalf of the University of Nevada, Las Vegas
 
<120>  LIGAND-GUIDED PHAGOCYTOSIS BASED THERAPY FOR TREATMENT OF 
       ALZHEIMER'S DISEASE AND OTHER NEURODEGENERATIVE DISEASES

<130>  37474.0053U2

<150>  62/254,846
<151>  2015-11-13

<160>  37    

<170>  PatentIn version 3.5

<210>  1
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; amyloid beta binding protein

<400>  1

Leu Asp Leu Ser Asn Glu Gly Leu Ser Gly Ser Leu Asn Gly Thr Leu 
1               5                   10                  15      


Asp Lys Thr Leu Lys Gln Pro Leu 
            20                  


<210>  2
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; amyloid beta binding protein

<400>  2

Pro Ala Glu Cys Asp Trp Gly Lys Gly Gly Arg Trp Arg Leu Trp Pro 
1               5                   10                  15      


Gly Ala Ser Gly Lys Thr Glu Ala Cys Gly Pro Pro Tyr 
            20                  25                  


<210>  3
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; amyloid beta binding protein

<400>  3

Lys Ile Gly Lys Val Val Phe Pro Asp Cys Ile Ala Ser Asp Pro Phe 
1               5                   10                  15      


Lys Leu Val Val Asp Asp Thr Leu Ser Tyr Val Ala Glu Ile Arg Gly 
            20                  25                  30          


Ile Leu Pro Arg Ser Asp 
        35              


<210>  4
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; amyloid beta binding protein

<400>  4

Met Ala Val Trp Ala Lys Val Arg Ser Ala Leu Ala Val Glu Ala Val 
1               5                   10                  15      


Val Gly Asp Lys Ala Asp Lys Val Ala Leu Asp 
            20                  25          


<210>  5
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; amyloid beta binding protein

<400>  5

Leu Gly Val Gln Tyr Ala Lys Gly Ile Ser Gln Gly Glu Leu Val Val 
1               5                   10                  15      


Ser Ser Ala Pro Val Gln Asp Phe Ala Pro Ile Ala Lys Leu Leu Ile 
            20                  25                  30          


<210>  6
<211>  45
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; amyloid beta binding protein

<400>  6

Arg Leu Gly Arg Gly Leu Leu Ala Lys Leu Asp Leu Lys Trp Leu Lys 
1               5                   10                  15      


Leu Glu Arg Asp Gly Thr Ala Ala Glu Lys Leu His Glu Asp Leu Lys 
            20                  25                  30          


Lys Ile Leu Arg Glu Glu Leu Arg Arg Glu Leu Leu Leu 
        35                  40                  45  


<210>  7
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; amyloid beta binding protein

<400>  7

Met Lys Ile Gly Ile Gly Lys Gly Glu Glu Ile Val Pro Glu Glu Glu 
1               5                   10                  15      


Lys Pro Ser Ala Lys Lys Leu Lys Leu Lys Lys Ala Leu Gly Leu Val 
            20                  25                  30          


Glu Gly Leu Phe 
        35      


<210>  8
<211>  46
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; amyloid beta binding protein

<400>  8

Pro Ser Phe Asp Gln Lys Leu Glu Ser Arg Leu Gln Ala Glu Leu Ser 
1               5                   10                  15      


Pro Gly Leu Gly His Ala Ile Glu Ala Ile Phe Leu Phe Ala Asp Asp 
            20                  25                  30          


Ala Lys Glu Gly Leu Ala Glu Asp Leu Leu Gly Glu Lys Ala 
        35                  40                  45      


<210>  9
<211>  99
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; amyloid beta binding protein

<400>  9

Lys Lys Gly Lys Leu Gly Glu Pro Phe Gln Leu Ile Gly Leu Leu Ile 
1               5                   10                  15      


Leu Ala Arg Phe Ile Ile Gln Lys Lys Lys Leu Asp Ala Leu Lys Glu 
            20                  25                  30          


Val Leu Glu Leu Ala Thr Lys Arg Leu Leu Lys Phe Asp Leu Lys Leu 
        35                  40                  45              


Glu Glu Arg Asp Leu Lys Lys Gln Glu Leu Leu Glu Leu Gln Glu Leu 
    50                  55                  60                  


Arg Lys Asp Val Leu Leu Ala Asp Leu Ala Asn Gln Asp Asp Asp Glu 
65                  70                  75                  80  


Ala Leu Leu Arg Ala Asp Lys Glu Ala Asp Ile Leu Glu Leu Glu Asn 
                85                  90                  95      


Ala Asp Lys 
            


<210>  10
<211>  104
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; amyloid beta binding protein

<400>  10

Val Gly Gly Asp Val Val Glu Gly Thr Ser His Ser Gly Leu Ile Thr 
1               5                   10                  15      


Asp Leu Gly Val Val Asn Gly Gly Arg Ala Leu Leu Ser Gly Pro Glu 
            20                  25                  30          


Pro Leu Asn Gly Thr Asp Leu Pro Ala Leu Leu Ala Ala Gly Leu Leu 
        35                  40                  45              


Phe Glu Leu Ser Glu Ala Pro Glu Ile Leu Val Gly Glu Tyr Ser Thr 
    50                  55                  60                  


Val Ser Leu Val Ala Val Gly Ala Glu Val Pro Leu Glu Asp Tyr Leu 
65                  70                  75                  80  


Asp Glu Gly Asp Lys His Gly Glu Ala Leu Ser Asp Tyr Trp Asp Gln 
                85                  90                  95      


Leu Leu Glu Leu Ser Ile Leu Leu 
            100                 


<210>  11
<211>  78
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; amyloid beta binding protein

<400>  11

Val Gly Gly Glu Gly Ile Ser Gly Thr Ile Phe Asn Ile Tyr Gly Gly 
1               5                   10                  15      


Phe Ile Pro Gly Lys Leu Arg Arg Leu Pro Asp Ala Glu Ile Trp Gly 
            20                  25                  30          


Gly Leu Ser Leu Gly Gly Asp Gln Arg Phe Gly Asp Gly Thr Ala Val 
        35                  40                  45              


Ile Gly Leu Ser Val Ser Leu Lys Ser Gly Gly Ala Glu Leu Val Ala 
    50                  55                  60                  


Glu Leu Tyr Val Asp Pro Gly Val Ser Ser Gln Pro Glu Glu 
65                  70                  75              


<210>  12
<211>  58
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; amyloid beta binding protein

<400>  12

Met Leu Val Asp Gly Gly Lys Leu Gly Val Leu Ala Lys Gln Leu Lys 
1               5                   10                  15      


Glu Tyr Leu Ala Phe Asp Arg Asp Leu Asp Asp Leu Val Phe Lys Ala 
            20                  25                  30          


Lys Ile Gln Val Asn Asp Gly Ala Leu Gly Val Ile Ser Asn Leu Leu 
        35                  40                  45              


Phe Gly Gly Gly Ile Val Gly Gln Ile Leu 
    50                  55              


<210>  13
<211>  93
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; amyloid beta binding protein

<400>  13

Ser Leu Ala Leu Leu Val Glu Thr Asn Glu Leu Asp Asp Ala Ala Val 
1               5                   10                  15      


Glu Leu Ile Arg Lys Leu Gly Gly Thr Asp Ala Glu Leu Lys Ile Ile 
            20                  25                  30          


Leu Ala Gly Asp Gly Ile Asp Gly Ile Ser Trp Pro Ala Leu Gly Asn 
        35                  40                  45              


Glu Ala Gly Asp Leu Val Gly Ser Ser Gly Ile Ala Gly Gly Lys Pro 
    50                  55                  60                  


Val Leu Pro Asp Glu Ala Phe Val Arg Leu Ser Val Asn Ala Ser Gly 
65                  70                  75                  80  


Gly Phe Val Asp Gly Ile Lys Glu Gly Pro Val Val Leu 
                85                  90              


<210>  14
<211>  80
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; amyloid beta binding protein

<400>  14

Gly Asp Gly Pro Ser Asp Leu Glu Val Val Arg Leu Ile Thr Pro Gly 
1               5                   10                  15      


Gln Ala Leu Ala Pro Phe Thr Asn Ala Gly Gln Ala Ala Ala Val Pro 
            20                  25                  30          


Arg Ser Glu Gly Glu Ser Met Ile Ala Val Ser His Asn Met Leu Pro 
        35                  40                  45              


Gln Val Ser Ser Glu Val Val Glu Gly Tyr Ala Thr Lys Asn Glu Thr 
    50                  55                  60                  


Glu Asn Glu Thr Leu Cys Met Lys Ile Gly Pro Pro Ile Val Gly Glu 
65                  70                  75                  80  


<210>  15
<211>  62
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; amyloid beta binding protein

<400>  15

Arg Pro Asp Glu Ile Val Gly Val Trp Ser Ser Tyr Leu Gly Leu Gly 
1               5                   10                  15      


Phe Val Leu Ser Lys Ala Val Ile Leu Glu Leu Leu Arg Asn Trp Phe 
            20                  25                  30          


Gly Lys Gln Ser Gly Ala Tyr Leu Asp Tyr Leu His Gly Ser Val Ala 
        35                  40                  45              


Leu Leu Gly Asp Lys Asn Met Gly Arg Lys Leu Ser Gln Ser 
    50                  55                  60          


<210>  16
<211>  73
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; amyloid beta binding protein

<400>  16

His Leu Leu Ile Asp Lys Gly Val Ala Gly Gly Pro Gly Phe Asp Thr 
1               5                   10                  15      


Val Ala Ser Leu Ala Glu Thr Glu Lys Ala Arg Gly Pro Glu Val Ser 
            20                  25                  30          


Thr Leu Ala Lys Glu Asp Phe Ala Lys Thr Ile Gly Glu Leu Gly Ala 
        35                  40                  45              


Gly Pro Lys Thr Ser Lys Ala Val Val Gly Glu Gly Gly Lys Glu Ile 
    50                  55                  60                  


Pro Leu Gly Pro Gly Lys Ser Tyr Pro 
65                  70              


<210>  17
<211>  65
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; amyloid beta binding protein

<400>  17

Ser Ser Ser Leu Phe Gln Leu Pro Thr Asp Gly Lys Leu Val Gln Ala 
1               5                   10                  15      


Leu Ile Thr Asn Leu Tyr Gly Ser Ala Leu Asp Gly Tyr Glu Val Arg 
            20                  25                  30          


Asp Leu Glu Leu Ile Met Glu Lys Arg Leu Val Ile Ser Ile Asn Gly 
        35                  40                  45              


Arg Ile Pro Ala Glu Phe Asn Gln Asp Leu Gly Leu Arg Leu Leu Leu 
    50                  55                  60                  


Thr 
65  


<210>  18
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; mutant amyloid beta binding protein

<400>  18

Pro Ala Glu Cys Asp Trp Gly Lys Gly Gly Arg Trp Arg Leu Trp Pro 
1               5                   10                  15      


Ser Ala Ser Gly Lys Thr Glu Ala Cys Gly Pro Pro Tyr 
            20                  25                  


<210>  19
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; mutant amyloid beta binding protein

<400>  19

Pro Ala Glu Cys Asp Trp Gly Lys Gly Gly Arg Trp Arg Asp Trp Pro 
1               5                   10                  15      


Gly Ala Ser Gly Lys Thr Glu Ala Cys Gly Pro Pro Tyr 
            20                  25                  


<210>  20
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; mutant amyloid beta binding protein

<400>  20

Pro Ala Glu Cys Asp Trp Gly Lys Gly Gly Arg Trp Arg Leu Trp Pro 
1               5                   10                  15      


Gly Ser Ser Gly Lys Thr Glu Ala Cys Gly Pro Pro Tyr 
            20                  25                  


<210>  21
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; mutant amyloid beta binding protein

<400>  21

Pro Ala Glu Cys Asp Trp Lys Lys Gly Gly Arg Trp Arg Leu Trp Pro 
1               5                   10                  15      


Gly Ala Ser Gly Lys Thr Glu Ala Cys Gly Pro Pro Tyr 
            20                  25                  


<210>  22
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; mutant amyloid beta binding protein

<400>  22

Pro Ala Glu Cys Asp Trp Gly Lys Gly Gly Leu Trp Arg Leu Trp Pro 
1               5                   10                  15      


Gly Ala Ser Gly Lys Thr Glu Ala Cys Gly Pro Pro Tyr 
            20                  25                  


<210>  23
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; mutant amyloid beta binding protein

<400>  23

Pro Ala Glu Cys Asp Trp Gly Lys Gly Arg Arg Trp Arg Ser Trp Pro 
1               5                   10                  15      


Gly Ala Ser Gly Lys Thr Glu Ala Cys Gly Pro Pro Tyr 
            20                  25                  


<210>  24
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; mutant amyloid beta binding protein

<400>  24

Pro Ala Glu Cys Asp Trp Gly Lys Gly Gly Arg Trp Arg Leu Trp Pro 
1               5                   10                  15      


Gly Ala Ser Gly Lys Thr Asp Ala Cys Gly Pro Pro Tyr 
            20                  25                  


<210>  25
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; mutant amyloid beta binding protein

<400>  25

Pro Ala Glu Cys Asp Trp Gly Lys Gly Gly Arg Trp Arg Leu Arg Pro 
1               5                   10                  15      


Gly Ala Ser Gly Lys Thr Glu Ala Cys Gly Pro Pro Tyr 
            20                  25                  


<210>  26
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; mutant amyloid beta binding protein

<400>  26

Pro Ala Glu Cys Asp Trp Gly Lys Gly Gly Arg Trp Arg Leu Trp Pro 
1               5                   10                  15      


Gly Ala Ser Leu Lys Thr Glu Ala Cys Gly Pro Pro Tyr 
            20                  25                  


<210>  27
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; mutant amyloid beta binding protein

<400>  27

Pro Ala Glu Cys Asp Trp Gly Lys Lys Gly Arg Trp Arg Leu Trp Pro 
1               5                   10                  15      


Gly Ala Ser Gly Lys Thr Glu Ala Cys Gly Pro Pro Tyr 
            20                  25                  


<210>  28
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; mutant amyloid beta binding protein

<400>  28

Leu Asp Leu Ser Asn Arg Gly Ser Ser Gly Ser Leu Asn Gly Thr Ser 
1               5                   10                  15      


Asp Lys Thr Leu Lys Gln Pro Leu 
            20                  


<210>  29
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; mutant amyloid beta binding protein

<400>  29

Leu Asp Leu Ser Asn Arg Gly Ser Ser Gly Ser Ser Asn Gly Thr Leu 
1               5                   10                  15      


Asp Lys Thr Leu Lys Gln Pro Leu 
            20                  


<210>  30
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; mutant amyloid beta binding protein

<400>  30

Leu Asp Leu Ser Asn Glu Gly Ser Ser Gly Ser Ser Ser Gly Thr Leu 
1               5                   10                  15      


Asp Lys Thr Leu Lys Gln Pro Leu 
            20                  


<210>  31
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; mutant amyloid beta binding protein

<400>  31

Leu Asp Leu Ser Asn Glu Gly Arg Ser Gly Ser Ser Asn Gly Thr Ser 
1               5                   10                  15      


Asp Lys Thr Leu Lys Gln Pro Leu 
            20                  


<210>  32
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; mutant amyloid beta binding protein

<400>  32

Leu Asp Leu Ser Asn Glu Ser Ser Ser Gly Ser Leu Ser Gly Thr Ser 
1               5                   10                  15      


Asp Lys Thr Leu Lys Gln Pro Leu 
            20                  


<210>  33
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; mutant amyloid beta binding protein

<400>  33

Leu Asp Leu Ser Asn Glu Gly Leu Ser Gly Ser Ser Ser Gly Ser Ser 
1               5                   10                  15      


Asp Lys Thr Leu Lys Gln Pro Leu 
            20                  


<210>  34
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct;  amyloid beta binding protein and MerTK 
       ligand conjugate

<400>  34

Lys Arg Arg Lys Lys Lys Gly Ser Gly Lys Arg Arg Lys Lys Lys Gly 
1               5                   10                  15      


Ser Gly Lys Arg Arg Lys Lys Lys Gly Ser Gly Leu Asp Leu Ser Asn 
            20                  25                  30          


Glu Gly Leu Ser Gly Ser Leu Asn Gly Thr Leu Asp Lys Thr Leu Lys 
        35                  40                  45              


Gln Pro Leu Gly Ser Gly Leu Asp Leu Ser Asn Glu Gly Leu Ser Gly 
    50                  55                  60                  


Ser Leu Asn Gly Thr Leu Asp Lys Thr Leu Lys Gln Pro Leu Gly Ser 
65                  70                  75                  80  


Gly Leu Asp Leu Ser Asn Glu Gly Leu Ser Gly Ser Leu Asn Gly Thr 
                85                  90                  95      


Leu Asp Lys Thr Leu Lys Gln Pro Leu 
            100                 105 


<210>  35
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; amyloid beta binding protein and MerTK 
       ligand conjugate

<400>  35

Lys Arg Arg Lys Lys Lys Gly Ser Gly Lys Arg Arg Lys Lys Lys Gly 
1               5                   10                  15      


Ser Gly Lys Arg Arg Lys Lys Lys Gly Ser Gly Leu Asp Leu Ser Asn 
            20                  25                  30          


Glu Gly Leu Ser Gly Ser Ser Ser Gly Ser Ser Asp Lys Thr Leu Lys 
        35                  40                  45              


Gln Pro Leu Gly Ser Gly Leu Asp Leu Ser Asn Glu Gly Leu Ser Gly 
    50                  55                  60                  


Ser Ser Ser Gly Ser Ser Asp Lys Thr Leu Lys Gln Pro Leu Gly Ser 
65                  70                  75                  80  


Gly Leu Asp Leu Ser Asn Glu Gly Leu Ser Gly Ser Ser Ser Gly Ser 
                85                  90                  95      


Ser Asp Lys Thr Leu Lys Gln Pro Leu 
            100                 105 


<210>  36
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; MerTK ligand

<400>  36

Lys Arg Arg Lys Lys Lys 
1               5       


<210>  37
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; MerTK ligand

<400>  37

Lys Gln Lys Lys Lys 
1               5   


