                         SEQUENCE LISTING

<110>  Strong, Roland  K
       Prlic, Martin
       Gewe, Mesfin
       Spies, Thomas
       Spies, Veronika
       Rupert, Peter
 
<120>  NKG2D Decoys

<130>  F053-0027PCT

<150>  US 62/253,590
<151>  2015-11-10

<160>  79    

<170>  PatentIn version 3.5

<210>  1
<211>  216
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Gly Trp Ile Arg Gly Arg Arg Ser Arg His Ser Trp Glu Met Ser 
1               5                   10                  15      


Glu Phe His Asn Tyr Asn Leu Asp Leu Lys Lys Ser Asp Phe Ser Thr 
            20                  25                  30          


Arg Trp Gln Lys Gln Arg Cys Pro Val Val Lys Ser Lys Cys Arg Glu 
        35                  40                  45              


Asn Ala Ser Pro Phe Phe Phe Cys Cys Phe Ile Ala Val Ala Met Gly 
    50                  55                  60                  


Ile Arg Phe Ile Ile Met Val Ala Ile Trp Ser Ala Val Phe Leu Asn 
65                  70                  75                  80  


Ser Leu Phe Asn Gln Glu Val Gln Ile Pro Leu Thr Glu Ser Tyr Cys 
                85                  90                  95      


Gly Pro Cys Pro Lys Asn Trp Ile Cys Tyr Lys Asn Asn Cys Tyr Gln 
            100                 105                 110         


Phe Phe Asp Glu Ser Lys Asn Trp Tyr Glu Ser Gln Ala Ser Cys Met 
        115                 120                 125             


Ser Gln Asn Ala Ser Leu Leu Lys Val Tyr Ser Lys Glu Asp Gln Asp 
    130                 135                 140                 


Leu Leu Lys Leu Val Lys Ser Tyr His Trp Met Gly Leu Val His Ile 
145                 150                 155                 160 


Pro Thr Asn Gly Ser Trp Gln Trp Glu Asp Gly Ser Ile Leu Ser Pro 
                165                 170                 175     


Asn Leu Leu Thr Ile Ile Glu Met Gln Lys Gly Asp Cys Ala Leu Tyr 
            180                 185                 190         


Ala Ser Ser Phe Lys Gly Tyr Ile Glu Asn Cys Ser Thr Pro Asn Thr 
        195                 200                 205             


Tyr Ile Cys Met Gln Arg Thr Val 
    210                 215     


<210>  2
<211>  219
<212>  PRT
<213>  Mus musculus

<400>  2

Met Ser Lys Cys His Asn Tyr Asp Leu Lys Pro Ala Lys Trp Asp Thr 
1               5                   10                  15      


Ser Gln Glu Gln Gln Lys Gln Arg Leu Ala Leu Thr Thr Ser Gln Pro 
            20                  25                  30          


Gly Glu Asn Gly Ile Ile Arg Gly Arg Tyr Pro Ile Glu Lys Leu Lys 
        35                  40                  45              


Ile Ser Pro Met Phe Val Val Arg Val Leu Ala Ile Ala Leu Ala Ile 
    50                  55                  60                  


Arg Phe Thr Leu Asn Thr Leu Met Trp Leu Ala Ile Phe Lys Glu Thr 
65                  70                  75                  80  


Phe Gln Pro Val Leu Cys Asn Lys Glu Val Pro Val Ser Ser Arg Glu 
                85                  90                  95      


Gly Tyr Cys Gly Pro Cys Pro Asn Asn Trp Ile Cys His Arg Asn Asn 
            100                 105                 110         


Cys Tyr Gln Phe Phe Asn Glu Glu Lys Thr Trp Asn Gln Ser Gln Ala 
        115                 120                 125             


Ser Cys Leu Ser Gln Asn Ser Ser Leu Leu Lys Ile Tyr Ser Lys Glu 
    130                 135                 140                 


Glu Gln Asp Phe Leu Lys Leu Val Lys Ser Tyr His Trp Met Gly Leu 
145                 150                 155                 160 


Val Gln Ile Pro Ala Asn Gly Ser Trp Gln Trp Glu Asp Gly Ser Ser 
                165                 170                 175     


Leu Ser Tyr Asn Gln Leu Thr Leu Val Glu Ile Pro Lys Gly Ser Cys 
            180                 185                 190         


Ala Val Tyr Gly Ser Ser Phe Lys Ala Tyr Thr Glu Asp Cys Ala Asn 
        195                 200                 205             


Leu Asn Thr Tyr Ile Cys Met Lys Arg Ala Val 
    210                 215                 


<210>  3
<211>  262
<212>  PRT
<213>  Homo sapiens

<400>  3

Asn Gln Glu Val Gln Ile Pro Leu Thr Glu Ser Tyr Cys Gly Pro Cys 
1               5                   10                  15      


Pro Lys Asn Trp Ile Cys Tyr Lys Asn Asn Cys Tyr Gln Phe Phe Asp 
            20                  25                  30          


Glu Ser Lys Asn Trp Tyr Glu Ser Gln Ala Ser Cys Met Ser Gln Asn 
        35                  40                  45              


Ala Ser Leu Leu Lys Val Tyr Ser Lys Glu Asp Gln Asp Leu Leu Lys 
    50                  55                  60                  


Leu Val Lys Ser Tyr His Trp Met Gly Leu Val His Ile Pro Thr Asn 
65                  70                  75                  80  


Gly Ser Trp Gln Trp Glu Asp Gly Ser Ile Leu Ser Pro Asn Leu Leu 
                85                  90                  95      


Thr Ile Ile Glu Met Gln Lys Gly Asp Cys Ala Leu Tyr Ala Ser Ser 
            100                 105                 110         


Phe Lys Gly Tyr Ile Glu Asn Cys Ser Thr Pro Asn Thr Tyr Ile Cys 
        115                 120                 125             


Met Gln Arg Thr Val Gln Ile Pro Leu Thr Glu Ser Tyr Cys Gly Pro 
    130                 135                 140                 


Cys Pro Lys Asn Trp Ile Cys Tyr Lys Asn Asn Cys Tyr Gln Phe Phe 
145                 150                 155                 160 


Asp Glu Ser Lys Asn Trp Tyr Glu Ser Gln Ala Ser Cys Met Ser Gln 
                165                 170                 175     


Asn Ala Ser Leu Leu Lys Val Tyr Ser Lys Glu Asp Gln Asp Leu Leu 
            180                 185                 190         


Lys Leu Val Lys Ser Tyr His Trp Met Gly Leu Val His Ile Pro Thr 
        195                 200                 205             


Asn Gly Ser Trp Gln Trp Glu Asp Gly Ser Ile Leu Ser Pro Asn Leu 
    210                 215                 220                 


Leu Thr Ile Ile Glu Met Gln Lys Gly Asp Cys Ala Leu Tyr Ala Ser 
225                 230                 235                 240 


Ser Phe Lys Gly Tyr Ile Glu Asn Cys Ser Thr Pro Asn Thr Tyr Ile 
                245                 250                 255     


Cys Met Gln Arg Thr Val 
            260         


<210>  4
<211>  262
<212>  PRT
<213>  Mus musculus

<400>  4

Asn Lys Glu Val Pro Val Ser Ser Arg Glu Gly Tyr Cys Gly Pro Cys 
1               5                   10                  15      


Pro Asn Asn Trp Ile Cys His Arg Asn Asn Cys Tyr Gln Phe Phe Asn 
            20                  25                  30          


Glu Glu Lys Thr Trp Asn Gln Ser Gln Ala Ser Cys Leu Ser Gln Asn 
        35                  40                  45              


Ser Ser Leu Leu Lys Ile Tyr Ser Lys Glu Glu Gln Asp Phe Leu Lys 
    50                  55                  60                  


Leu Val Lys Ser Tyr His Trp Met Gly Leu Val Gln Ile Pro Ala Asn 
65                  70                  75                  80  


Gly Ser Trp Gln Trp Glu Asp Gly Ser Ser Leu Ser Tyr Asn Gln Leu 
                85                  90                  95      


Thr Leu Val Glu Ile Pro Lys Gly Ser Cys Ala Val Tyr Gly Ser Ser 
            100                 105                 110         


Phe Lys Ala Tyr Thr Glu Asp Cys Ala Asn Leu Asn Thr Tyr Ile Cys 
        115                 120                 125             


Met Lys Arg Ala Val Pro Val Ser Ser Arg Glu Gly Tyr Cys Gly Pro 
    130                 135                 140                 


Cys Pro Asn Asn Trp Ile Cys His Arg Asn Asn Cys Tyr Gln Phe Phe 
145                 150                 155                 160 


Asn Glu Glu Lys Thr Trp Asn Gln Ser Gln Ala Ser Cys Leu Ser Gln 
                165                 170                 175     


Asn Ser Ser Leu Leu Lys Ile Tyr Ser Lys Glu Glu Gln Asp Phe Leu 
            180                 185                 190         


Lys Leu Val Lys Ser Tyr His Trp Met Gly Leu Val Gln Ile Pro Ala 
        195                 200                 205             


Asn Gly Ser Trp Gln Trp Glu Asp Gly Ser Ser Leu Ser Tyr Asn Gln 
    210                 215                 220                 


Leu Thr Leu Val Glu Ile Pro Lys Gly Ser Cys Ala Val Tyr Gly Ser 
225                 230                 235                 240 


Ser Phe Lys Ala Tyr Thr Glu Asp Cys Ala Asn Leu Asn Thr Tyr Ile 
                245                 250                 255     


Cys Met Lys Arg Ala Val 
            260         


<210>  5
<211>  524
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  human bivalent NKG2Dscd concatamer

<400>  5

Asn Gln Glu Val Gln Ile Pro Leu Thr Glu Ser Tyr Cys Gly Pro Cys 
1               5                   10                  15      


Pro Lys Asn Trp Ile Cys Tyr Lys Asn Asn Cys Tyr Gln Phe Phe Asp 
            20                  25                  30          


Glu Ser Lys Asn Trp Tyr Glu Ser Gln Ala Ser Cys Met Ser Gln Asn 
        35                  40                  45              


Ala Ser Leu Leu Lys Val Tyr Ser Lys Glu Asp Gln Asp Leu Leu Lys 
    50                  55                  60                  


Leu Val Lys Ser Tyr His Trp Met Gly Leu Val His Ile Pro Thr Asn 
65                  70                  75                  80  


Gly Ser Trp Gln Trp Glu Asp Gly Ser Ile Leu Ser Pro Asn Leu Leu 
                85                  90                  95      


Thr Ile Ile Glu Met Gln Lys Gly Asp Cys Ala Leu Tyr Ala Ser Ser 
            100                 105                 110         


Phe Lys Gly Tyr Ile Glu Asn Cys Ser Thr Pro Asn Thr Tyr Ile Cys 
        115                 120                 125             


Met Gln Arg Thr Val Gln Ile Pro Leu Thr Glu Ser Tyr Cys Gly Pro 
    130                 135                 140                 


Cys Pro Lys Asn Trp Ile Cys Tyr Lys Asn Asn Cys Tyr Gln Phe Phe 
145                 150                 155                 160 


Asp Glu Ser Lys Asn Trp Tyr Glu Ser Gln Ala Ser Cys Met Ser Gln 
                165                 170                 175     


Asn Ala Ser Leu Leu Lys Val Tyr Ser Lys Glu Asp Gln Asp Leu Leu 
            180                 185                 190         


Lys Leu Val Lys Ser Tyr His Trp Met Gly Leu Val His Ile Pro Thr 
        195                 200                 205             


Asn Gly Ser Trp Gln Trp Glu Asp Gly Ser Ile Leu Ser Pro Asn Leu 
    210                 215                 220                 


Leu Thr Ile Ile Glu Met Gln Lys Gly Asp Cys Ala Leu Tyr Ala Ser 
225                 230                 235                 240 


Ser Phe Lys Gly Tyr Ile Glu Asn Cys Ser Thr Pro Asn Thr Tyr Ile 
                245                 250                 255     


Cys Met Gln Arg Thr Val Asn Gln Glu Val Gln Ile Pro Leu Thr Glu 
            260                 265                 270         


Ser Tyr Cys Gly Pro Cys Pro Lys Asn Trp Ile Cys Tyr Lys Asn Asn 
        275                 280                 285             


Cys Tyr Gln Phe Phe Asp Glu Ser Lys Asn Trp Tyr Glu Ser Gln Ala 
    290                 295                 300                 


Ser Cys Met Ser Gln Asn Ala Ser Leu Leu Lys Val Tyr Ser Lys Glu 
305                 310                 315                 320 


Asp Gln Asp Leu Leu Lys Leu Val Lys Ser Tyr His Trp Met Gly Leu 
                325                 330                 335     


Val His Ile Pro Thr Asn Gly Ser Trp Gln Trp Glu Asp Gly Ser Ile 
            340                 345                 350         


Leu Ser Pro Asn Leu Leu Thr Ile Ile Glu Met Gln Lys Gly Asp Cys 
        355                 360                 365             


Ala Leu Tyr Ala Ser Ser Phe Lys Gly Tyr Ile Glu Asn Cys Ser Thr 
    370                 375                 380                 


Pro Asn Thr Tyr Ile Cys Met Gln Arg Thr Val Gln Ile Pro Leu Thr 
385                 390                 395                 400 


Glu Ser Tyr Cys Gly Pro Cys Pro Lys Asn Trp Ile Cys Tyr Lys Asn 
                405                 410                 415     


Asn Cys Tyr Gln Phe Phe Asp Glu Ser Lys Asn Trp Tyr Glu Ser Gln 
            420                 425                 430         


Ala Ser Cys Met Ser Gln Asn Ala Ser Leu Leu Lys Val Tyr Ser Lys 
        435                 440                 445             


Glu Asp Gln Asp Leu Leu Lys Leu Val Lys Ser Tyr His Trp Met Gly 
    450                 455                 460                 


Leu Val His Ile Pro Thr Asn Gly Ser Trp Gln Trp Glu Asp Gly Ser 
465                 470                 475                 480 


Ile Leu Ser Pro Asn Leu Leu Thr Ile Ile Glu Met Gln Lys Gly Asp 
                485                 490                 495     


Cys Ala Leu Tyr Ala Ser Ser Phe Lys Gly Tyr Ile Glu Asn Cys Ser 
            500                 505                 510         


Thr Pro Asn Thr Tyr Ile Cys Met Gln Arg Thr Val 
        515                 520                 


<210>  6
<211>  524
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  murine bivalent NKG2Dscd concatamer

<400>  6

Asn Lys Glu Val Pro Val Ser Ser Arg Glu Gly Tyr Cys Gly Pro Cys 
1               5                   10                  15      


Pro Asn Asn Trp Ile Cys His Arg Asn Asn Cys Tyr Gln Phe Phe Asn 
            20                  25                  30          


Glu Glu Lys Thr Trp Asn Gln Ser Gln Ala Ser Cys Leu Ser Gln Asn 
        35                  40                  45              


Ser Ser Leu Leu Lys Ile Tyr Ser Lys Glu Glu Gln Asp Phe Leu Lys 
    50                  55                  60                  


Leu Val Lys Ser Tyr His Trp Met Gly Leu Val Gln Ile Pro Ala Asn 
65                  70                  75                  80  


Gly Ser Trp Gln Trp Glu Asp Gly Ser Ser Leu Ser Tyr Asn Gln Leu 
                85                  90                  95      


Thr Leu Val Glu Ile Pro Lys Gly Ser Cys Ala Val Tyr Gly Ser Ser 
            100                 105                 110         


Phe Lys Ala Tyr Thr Glu Asp Cys Ala Asn Leu Asn Thr Tyr Ile Cys 
        115                 120                 125             


Met Lys Arg Ala Val Pro Val Ser Ser Arg Glu Gly Tyr Cys Gly Pro 
    130                 135                 140                 


Cys Pro Asn Asn Trp Ile Cys His Arg Asn Asn Cys Tyr Gln Phe Phe 
145                 150                 155                 160 


Asn Glu Glu Lys Thr Trp Asn Gln Ser Gln Ala Ser Cys Leu Ser Gln 
                165                 170                 175     


Asn Ser Ser Leu Leu Lys Ile Tyr Ser Lys Glu Glu Gln Asp Phe Leu 
            180                 185                 190         


Lys Leu Val Lys Ser Tyr His Trp Met Gly Leu Val Gln Ile Pro Ala 
        195                 200                 205             


Asn Gly Ser Trp Gln Trp Glu Asp Gly Ser Ser Leu Ser Tyr Asn Gln 
    210                 215                 220                 


Leu Thr Leu Val Glu Ile Pro Lys Gly Ser Cys Ala Val Tyr Gly Ser 
225                 230                 235                 240 


Ser Phe Lys Ala Tyr Thr Glu Asp Cys Ala Asn Leu Asn Thr Tyr Ile 
                245                 250                 255     


Cys Met Lys Arg Ala Val Asn Lys Glu Val Pro Val Ser Ser Arg Glu 
            260                 265                 270         


Gly Tyr Cys Gly Pro Cys Pro Asn Asn Trp Ile Cys His Arg Asn Asn 
        275                 280                 285             


Cys Tyr Gln Phe Phe Asn Glu Glu Lys Thr Trp Asn Gln Ser Gln Ala 
    290                 295                 300                 


Ser Cys Leu Ser Gln Asn Ser Ser Leu Leu Lys Ile Tyr Ser Lys Glu 
305                 310                 315                 320 


Glu Gln Asp Phe Leu Lys Leu Val Lys Ser Tyr His Trp Met Gly Leu 
                325                 330                 335     


Val Gln Ile Pro Ala Asn Gly Ser Trp Gln Trp Glu Asp Gly Ser Ser 
            340                 345                 350         


Leu Ser Tyr Asn Gln Leu Thr Leu Val Glu Ile Pro Lys Gly Ser Cys 
        355                 360                 365             


Ala Val Tyr Gly Ser Ser Phe Lys Ala Tyr Thr Glu Asp Cys Ala Asn 
    370                 375                 380                 


Leu Asn Thr Tyr Ile Cys Met Lys Arg Ala Val Pro Val Ser Ser Arg 
385                 390                 395                 400 


Glu Gly Tyr Cys Gly Pro Cys Pro Asn Asn Trp Ile Cys His Arg Asn 
                405                 410                 415     


Asn Cys Tyr Gln Phe Phe Asn Glu Glu Lys Thr Trp Asn Gln Ser Gln 
            420                 425                 430         


Ala Ser Cys Leu Ser Gln Asn Ser Ser Leu Leu Lys Ile Tyr Ser Lys 
        435                 440                 445             


Glu Glu Gln Asp Phe Leu Lys Leu Val Lys Ser Tyr His Trp Met Gly 
    450                 455                 460                 


Leu Val Gln Ile Pro Ala Asn Gly Ser Trp Gln Trp Glu Asp Gly Ser 
465                 470                 475                 480 


Ser Leu Ser Tyr Asn Gln Leu Thr Leu Val Glu Ile Pro Lys Gly Ser 
                485                 490                 495     


Cys Ala Val Tyr Gly Ser Ser Phe Lys Ala Tyr Thr Glu Asp Cys Ala 
            500                 505                 510         


Asn Leu Asn Thr Tyr Ile Cys Met Lys Arg Ala Val 
        515                 520                 


<210>  7
<211>  66
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  multimerization domain

<400>  7

Arg Ser Ala Gly Ala His Ala Gly Trp Glu Thr Pro Glu Gly Cys Glu 
1               5                   10                  15      


Gln Val Leu Thr Gly Lys Arg Leu Met Gln Cys Leu Pro Asn Pro Glu 
            20                  25                  30          


Asp Val Lys Met Ala Leu Glu Val Tyr Lys Leu Ser Leu Glu Ile Glu 
        35                  40                  45              


Gln Leu Glu Leu Gln Arg Asp Ser Ala Arg Gln Ser Thr Leu Asp Lys 
    50                  55                  60                  


Glu Leu 
65      


<210>  8
<211>  68
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  multimerization domain

<400>  8

Ser Gly Arg Ala His Ala Gly Trp Glu Thr Pro Glu Gly Cys Glu Gln 
1               5                   10                  15      


Val Leu Thr Gly Lys Arg Leu Met Gln Cys Leu Pro Asn Pro Glu Asp 
            20                  25                  30          


Val Lys Met Ala Leu Glu Val Tyr Lys Leu Ser Leu Glu Ile Glu Gln 
        35                  40                  45              


Leu Glu Leu Gln Arg Asp Ser Ala Arg Gln Ser Thr Leu Asp Lys Glu 
    50                  55                  60                  


Leu Val Pro Arg 
65              


<210>  9
<211>  55
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  multimerization domain

<400>  9

Lys Lys Gln Gly Asp Ala Asp Val Cys Gly Glu Val Ala Tyr Ile Gln 
1               5                   10                  15      


Ser Val Val Ser Asp Cys His Val Pro Thr Ala Glu Leu Arg Thr Leu 
            20                  25                  30          


Leu Glu Ile Arg Lys Leu Phe Leu Glu Ile Gln Lys Leu Lys Val Glu 
        35                  40                  45              


Leu Gln Gly Leu Ser Lys Glu 
    50                  55  


<210>  10
<211>  57
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  multimerization domain

<400>  10

Glu Thr Pro Glu Gly Cys Glu Gln Val Leu Thr Gly Lys Arg Leu Met 
1               5                   10                  15      


Gln Cys Leu Pro Asn Pro Glu Asp Val Lys Met Ala Leu Glu Val Tyr 
            20                  25                  30          


Lys Leu Ser Leu Glu Ile Glu Gln Leu Glu Leu Gln Arg Asp Ser Ala 
        35                  40                  45              


Arg Gln Ser Thr Leu Asp Lys Glu Leu 
    50                  55          


<210>  11
<211>  58
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  multimerization domain

<400>  11

Trp Glu Thr Pro Glu Gly Cys Glu Gln Val Leu Thr Gly Lys Arg Leu 
1               5                   10                  15      


Met Gln Cys Leu Pro Asn Pro Glu Asp Val Lys Met Ala Leu Glu Val 
            20                  25                  30          


Tyr Lys Leu Ser Leu Glu Ile Glu Gln Leu Glu Leu Gln Arg Asp Ser 
        35                  40                  45              


Ala Arg Gln Ser Thr Leu Asp Lys Glu Leu 
    50                  55              


<210>  12
<211>  52
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  multimerization domain

<400>  12

Cys Glu Gln Val Leu Thr Gly Lys Arg Leu Met Gln Cys Leu Pro Asn 
1               5                   10                  15      


Pro Glu Asp Val Lys Met Ala Leu Glu Val Tyr Lys Leu Ser Leu Glu 
            20                  25                  30          


Ile Glu Gln Leu Glu Leu Gln Arg Asp Ser Ala Arg Gln Ser Thr Leu 
        35                  40                  45              


Asp Lys Glu Leu 
    50          


<210>  13
<211>  57
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  multimerization domain

<400>  13

Glu Thr Pro Glu Gly Cys Glu Gln Val Leu Thr Gly Lys Arg Leu Met 
1               5                   10                  15      


Gln Cys Leu Pro Asn Pro Glu Asp Val Lys Met Ala Leu Glu Val Tyr 
            20                  25                  30          


Lys Leu Ser Leu Glu Ile Glu Gln Leu Glu Leu Gln Arg Asp Ser Ala 
        35                  40                  45              


Arg Gln Tyr Thr Leu Asp Lys Glu Leu 
    50                  55          


<210>  14
<211>  57
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  multimerization domain

<400>  14

Glu Thr Pro Glu Gly Cys Glu Gln Val Leu Ala Gly Lys Arg Leu Met 
1               5                   10                  15      


Gln Cys Leu Pro Asn Pro Glu Asp Val Lys Met Ala Leu Glu Val Tyr 
            20                  25                  30          


Lys Leu Ser Leu Glu Ile Glu Gln Leu Glu Leu Gln Arg Asp Arg Ala 
        35                  40                  45              


Arg Gln Ser Thr Leu Asp Lys Glu Leu 
    50                  55          


<210>  15
<211>  57
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  multimerization domain

<400>  15

Glu Thr Pro Glu Gly Cys Glu Gln Val Leu Ala Gly Lys Arg Leu Met 
1               5                   10                  15      


Gln Cys Leu Pro Asn Pro Glu Asp Val Lys Met Ala Leu Glu Val Tyr 
            20                  25                  30          


Lys Leu Ser Leu Glu Ile Glu Gln Leu Glu Leu Gln Arg Asp Arg Ala 
        35                  40                  45              


Arg Gln Ser Thr Trp Asp Lys Glu Leu 
    50                  55          


<210>  16
<211>  57
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  multimerization domain

<400>  16

Glu Val Pro Glu Gly Cys Glu Gln Val Gln Ala Gly Arg Arg Leu Met 
1               5                   10                  15      


Gln Cys Leu Ala Asp Pro Tyr Glu Val Lys Met Ala Leu Glu Val Tyr 
            20                  25                  30          


Lys Leu Ser Leu Glu Ile Glu Leu Leu Glu Leu Gln Arg Asp Lys Ala 
        35                  40                  45              


Arg Lys Ser Ser Val Leu Arg Gln Leu 
    50                  55          


<210>  17
<211>  57
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  multimerization domain

<400>  17

Val Val Pro Glu Gly Cys Glu His Ile Leu Lys Gly Arg Lys Thr Met 
1               5                   10                  15      


Gln Cys Leu Pro Asn Pro Glu Asp Val Lys Met Ala Leu Glu Ile Tyr 
            20                  25                  30          


Lys Leu Ser Leu Asp Ile Glu Leu Leu Glu Leu Gln Arg Asp Arg Ala 
        35                  40                  45              


Lys Glu Ser Thr Val Gln Ser Pro Val 
    50                  55          


<210>  18
<211>  55
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  multimerization domain

<400>  18

Glu Val Pro Lys Asp Cys Glu His Val Phe Ala Gly Lys Lys Leu Met 
1               5                   10                  15      


Gln Cys Leu Pro Asn Ser Asn Asp Val Lys Met Ala Leu Glu Val Tyr 
            20                  25                  30          


Lys Leu Thr Leu Glu Ile Lys Gln Leu Gln Leu Gln Ile Asp Lys Ala 
        35                  40                  45              


Lys His Val Asp Arg Glu Leu 
    50                  55  


<210>  19
<211>  57
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  multimerization domain

<400>  19

Glu Tyr Pro Glu Asp Cys Glu Gln Val His Glu Gly Lys Lys Leu Met 
1               5                   10                  15      


Gln Cys Leu Pro Asn Leu Glu Glu Ile Lys Leu Ala Leu Glu Leu Tyr 
            20                  25                  30          


Lys Leu Ser Leu Glu Thr Lys Leu Leu Glu Leu Gln Ile Asp Lys Glu 
        35                  40                  45              


Lys Lys Ala Lys Ala Lys Tyr Ser Ile 
    50                  55          


<210>  20
<211>  57
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  multimerization domain

<400>  20

Glu Tyr Pro Glu Asp Cys Glu Gln Val His Glu Gly Lys Lys Leu Met 
1               5                   10                  15      


Glu Cys Leu Pro Thr Leu Glu Glu Ile Lys Leu Ala Leu Ala Leu Tyr 
            20                  25                  30          


Lys Leu Ser Leu Glu Thr Asn Leu Leu Glu Leu Gln Ile Asp Lys Glu 
        35                  40                  45              


Lys Lys Ala Lys Ala Lys Tyr Ser Thr 
    50                  55          


<210>  21
<211>  57
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  multimerization domain

<400>  21

Glu Ile Ala Glu Gly Cys Glu Gln Val Leu Ala Gly Arg Lys Ile Met 
1               5                   10                  15      


Gln Cys Leu Pro Lys Pro Glu Asp Val Arg Thr Ala Leu Glu Leu Tyr 
            20                  25                  30          


Lys Leu Ser Leu Glu Ile Lys Gln Leu Glu Lys Lys Leu Glu Lys Glu 
        35                  40                  45              


Glu Lys Cys Thr Pro Glu Val Gln Glu 
    50                  55          


<210>  22
<211>  67
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  multimerization domain

<400>  22

Glu Tyr Pro Glu Gly Cys Glu Gln Val Val Thr Gly Arg Lys Leu Leu 
1               5                   10                  15      


Gln Cys Leu Ser Arg Pro Glu Glu Val Lys Leu Ala Leu Glu Val Tyr 
            20                  25                  30          


Lys Leu Ser Leu Glu Ile Glu Ile Leu Gln Thr Asn Lys Leu Lys Lys 
        35                  40                  45              


Glu Ala Phe Leu Leu Arg Glu Arg Glu Lys Asn Val Thr Cys Asp Phe 
    50                  55                  60                  


Asn Pro Glu 
65          


<210>  23
<211>  52
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  multimerization domain

<400>  23

Glu Tyr Pro Glu Gly Cys Glu Gln Val Val Thr Gly Arg Lys Leu Leu 
1               5                   10                  15      


Lys Cys Leu Ser Arg Pro Glu Glu Val Lys Leu Ala Leu Glu Val Tyr 
            20                  25                  30          


Lys Leu Ser Leu Glu Ile Ala Leu Leu Glu Leu Gln Ile Asp Lys Pro 
        35                  40                  45              


Lys Asp Ala Ser 
    50          


<210>  24
<211>  52
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  multimerization domain

<400>  24

Glu Val Pro Glu Asn Cys Glu Gln Val Ile Val Gly Lys Lys Leu Met 
1               5                   10                  15      


Lys Cys Leu Ser Asn Pro Asp Glu Ala Gln Met Ala Leu Gln Leu Tyr 
            20                  25                  30          


Lys Leu Ser Leu Glu Ala Glu Leu Leu Arg Leu Gln Ile Val Lys Ala 
        35                  40                  45              


Arg Gln Gly Ser 
    50          


<210>  25
<211>  54
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  multimerization domain

<400>  25

Glu Ala Ser Glu Asp Leu Lys Pro Ala Leu Thr Gly Asn Lys Thr Met 
1               5                   10                  15      


Gln Tyr Val Pro Asn Ser His Asp Val Lys Met Ala Leu Glu Ile Tyr 
            20                  25                  30          


Lys Leu Thr Leu Glu Val Glu Leu Leu Gln Leu Gln Ile Gln Lys Glu 
        35                  40                  45              


Lys His Thr Glu Ala His 
    50                  


<210>  26
<211>  51
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  multimerization domain

<400>  26

Val Ser Ala Glu Val Cys Glu Ala Val Phe Lys Gly Gln Lys Leu Leu 
1               5                   10                  15      


Lys Cys Leu Pro Asn Ala Met Glu Val Lys Met Ala Leu Glu Val Tyr 
            20                  25                  30          


Lys Leu Ser Leu Glu Ile Glu Lys Leu Glu Gln Glu Lys Arg Lys Leu 
        35                  40                  45              


Glu Ile Ala 
    50      


<210>  27
<211>  66
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  multimerization domain

<400>  27

Glu Val Pro Glu Glu Cys Lys Gln Val Ala Ala Gly Arg Lys Leu Leu 
1               5                   10                  15      


Glu Cys Leu Pro Asn Pro Ser Asp Val Lys Met Ala Leu Glu Val Tyr 
            20                  25                  30          


Lys Leu Ser Leu Glu Ile Glu Gln Leu Glu Lys Glu Lys Tyr Val Lys 
        35                  40                  45              


Ile Gln Glu Lys Phe Ser Lys Lys Glu Met Lys Gln Leu Thr Ser Ala 
    50                  55                  60                  


Leu His 
65      


<210>  28
<211>  59
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  multimerization domain

<400>  28

Glu Val Leu Glu Asp Cys Arg Ile Val Ser Arg Gly Ala Gln Leu Leu 
1               5                   10                  15      


His Cys Leu Ser Ser Pro Glu Asp Val His Arg Ala Leu Lys Val Tyr 
            20                  25                  30          


Lys Leu Phe Leu Glu Ile Glu Arg Leu Glu His Gln Lys Glu Lys Trp 
        35                  40                  45              


Ile Gln Leu His Arg Lys Pro Gln Ser Met Lys 
    50                  55                  


<210>  29
<211>  63
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  multimerization domain

<400>  29

Glu Gly Pro Glu Asp Cys Glu Ile Val Asn Lys Gly Arg Gln Leu Leu 
1               5                   10                  15      


Gln Cys Leu Ser Ser Pro Glu Asp Val Gln Arg Ala Leu Glu Val Tyr 
            20                  25                  30          


Lys Leu Ser Leu Glu Ile Glu Arg Leu Glu Gln Gln Arg Glu Lys Arg 
        35                  40                  45              


Thr Ser Val His Arg Lys Ala His Tyr Thr Lys Val Asp Gly Pro 
    50                  55                  60              


<210>  30
<211>  67
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  multimerization domain

<400>  30

Glu Ala Pro Glu Gly Cys Glu Gln Val Leu Thr Gly Arg Lys Leu Met 
1               5                   10                  15      


Gln Cys Leu Pro Ser Pro Glu Asp Val Lys Val Ala Leu Glu Val Tyr 
            20                  25                  30          


Lys Leu Ser Leu Glu Ile Lys Gln Leu Glu Lys Glu Arg Asp Lys Leu 
        35                  40                  45              


Met Asn Thr His Gln Lys Phe Ser Glu Lys Glu Glu Met Lys Asp Leu 
    50                  55                  60                  


Phe Phe Pro 
65          


<210>  31
<211>  52
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  multimerization domain

<400>  31

Glu Val Pro Glu Gly Cys Glu Gln Val Leu Thr Gly Lys Lys Leu Met 
1               5                   10                  15      


Gln Cys Leu Pro Asn Pro Glu Asp Val Lys Met Ala Leu Glu Val Tyr 
            20                  25                  30          


Lys Leu Ser Leu Glu Ile Glu Leu Leu Glu Leu Gln Ile Asp Lys Ala 
        35                  40                  45              


Arg Gln Gly Ser 
    50          


<210>  32
<211>  47
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  multimerization domain

<400>  32

Gly Cys Glu Gln Val Leu Thr Gly Lys Arg Leu Met Gln Cys Leu Pro 
1               5                   10                  15      


Asn Pro Glu Asp Val Lys Met Ala Leu Glu Val Tyr Lys Leu Ser Leu 
            20                  25                  30          


Glu Ile Glu Gln Leu Glu Leu Gln Arg Asp Ser Ala Arg Gln Ser 
        35                  40                  45          


<210>  33
<211>  51
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  multimerization domain

<400>  33

Glu Thr Pro Glu Gly Cys Glu Gln Val Leu Thr Gly Lys Arg Leu Met 
1               5                   10                  15      


Gln Cys Leu Pro Asn Pro Glu Asp Val Lys Met Ala Leu Glu Val Tyr 
            20                  25                  30          


Lys Leu Ser Leu Glu Ile Glu Gln Leu Glu Leu Gln Arg Asp Ser Ala 
        35                  40                  45              


Arg Gln Ser 
    50      


<210>  34
<211>  53
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  multimerization domain

<400>  34

Gly Ser Glu Gln Val Leu Thr Gly Lys Arg Leu Met Gln Ser Leu Pro 
1               5                   10                  15      


Asn Pro Glu Asp Val Lys Met Ala Leu Glu Val Tyr Lys Leu Ser Leu 
            20                  25                  30          


Glu Ile Glu Gln Leu Glu Leu Gln Arg Asp Ser Ala Arg Gln Ser Thr 
        35                  40                  45              


Leu Asp Lys Glu Leu 
    50              


<210>  35
<211>  57
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  multimerization domain

<400>  35

Glu Thr Pro Glu Gly Cys Glu Gln Val Leu Thr Gly Lys Arg Leu Met 
1               5                   10                  15      


Gln Cys Leu Pro Asn Pro Glu Asp Val Lys Met Ala Leu Glu Ile Tyr 
            20                  25                  30          


Lys Leu Thr Leu Glu Ile Glu Gln Leu Glu Leu Gln Arg Asp Ser Ala 
        35                  40                  45              


Arg Gln Ser Thr Leu Asp Lys Glu Leu 
    50                  55          


<210>  36
<211>  57
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  multimerization domain

<400>  36

Glu Thr Pro Glu Gly Cys Glu Gln Val Leu Thr Gly Lys Arg Leu Met 
1               5                   10                  15      


Gln Cys Leu Pro Asn Pro Glu Asp Val Lys Met Ala Leu Glu Ile Tyr 
            20                  25                  30          


Lys Leu Ser Leu Glu Ile Lys Gln Leu Glu Leu Gln Arg Asp Ser Ala 
        35                  40                  45              


Arg Gln Ser Thr Leu Asp Lys Glu Leu 
    50                  55          


<210>  37
<211>  50
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  multimerization domain

<400>  37

Glu Gly Cys Glu Gln Ile Leu Thr Gly Lys Arg Leu Met Gln Cys Leu 
1               5                   10                  15      


Pro Asp Pro Glu Asp Val Lys Met Ala Leu Glu Ile Tyr Lys Leu Ser 
            20                  25                  30          


Leu Glu Ile Lys Gln Leu Glu Leu Gln Arg Asp Arg Ala Arg Gln Ser 
        35                  40                  45              


Thr Leu 
    50  


<210>  38
<211>  57
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  multimerization domain

<400>  38

Glu Thr Pro Glu Gly Cys Glu Gln Val Leu Thr Gly Lys Arg Leu Met 
1               5                   10                  15      


Gln Cys Leu Pro Asn Pro Glu Asp Val Lys Met Ala Leu Glu Val Tyr 
            20                  25                  30          


Lys Leu Ser Leu Glu Ile Lys Gln Leu Glu Leu Gln Arg Asp Arg Ala 
        35                  40                  45              


Arg Gln Ser Thr Leu Asp Lys Glu Leu 
    50                  55          


<210>  39
<211>  52
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  multimerization domain

<400>  39

Glu Gly Cys Glu Gln Ile Leu Thr Gly Lys Arg Leu Met Gln Cys Leu 
1               5                   10                  15      


Pro Asn Pro Glu Asp Val Lys Met Ala Leu Glu Ile Tyr Lys Leu Ser 
            20                  25                  30          


Leu Glu Ile Glu Gln Leu Glu Leu Gln Arg Asp Arg Ala Arg Gln Ser 
        35                  40                  45              


Thr Leu Asp Lys 
    50          


<210>  40
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  40

Gly Ser Ser Gly Ser Ser Gly 
1               5           


<210>  41
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flag tag

<400>  41

Asp Tyr Lys Asp Glu 
1               5   


<210>  42
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  His tag

<400>  42

His His His His His His 
1               5       


<210>  43
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  His tag

<400>  43

Gly Ser His His His His His His 
1               5               


<210>  44
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  His tag

<400>  44

Gly Thr Lys His His His His His His 
1               5                   


<210>  45
<211>  178
<212>  PRT
<213>  Homo sapiens

<400>  45

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe Gln Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Leu Ala Gly Asn Ala Ile Leu Arg Glu Asp Lys Asp Pro 
        35                  40                  45              


Gln Lys Met Tyr Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  


Asn Val Thr Ser Val Leu Phe Arg Lys Lys Lys Cys Asp Tyr Trp Ile 
65                  70                  75                  80  


Arg Thr Phe Val Pro Gly Cys Gln Pro Gly Glu Phe Thr Leu Gly Asn 
                85                  90                  95      


Ile Lys Ser Tyr Pro Gly Leu Thr Ser Tyr Leu Val Arg Val Val Ser 
            100                 105                 110         


Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Lys Val Ser Gln 
        115                 120                 125             


Asn Arg Glu Tyr Phe Lys Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly 
        


<210>  46
<211>  180
<212>  PRT
<213>  Mus musculus

<400>  46

Gln Asp Ser Thr Gln Asn Leu Ile Pro Ala Pro Ser Leu Leu Thr Val 
1               5                   10                  15      


Pro Leu Gln Pro Asp Phe Arg Ser Asp Gln Phe Arg Gly Arg Trp Tyr 
            20                  25                  30          


Val Val Gly Leu Ala Gly Asn Ala Val Gln Lys Lys Thr Glu Gly Ser 
        35                  40                  45              


Phe Thr Met Tyr Ser Thr Ile Tyr Glu Leu Gln Glu Asn Asn Ser Tyr 
    50                  55                  60                  


Asn Val Thr Ser Ile Leu Val Arg Asp Gln Asp Gln Gly Cys Arg Tyr 
65                  70                  75                  80  


Trp Ile Arg Thr Phe Val Pro Ser Ser Arg Ala Gly Gln Phe Thr Leu 
                85                  90                  95      


Gly Asn Met His Arg Tyr Pro Gln Val Gln Ser Tyr Asn Val Gln Val 
            100                 105                 110         


Ala Thr Thr Asp Tyr Asn Gln Phe Ala Met Val Phe Phe Arg Lys Thr 
        115                 120                 125             


Ser Glu Asn Lys Gln Tyr Phe Lys Ile Thr Leu Tyr Gly Arg Thr Lys 
    130                 135                 140                 


Glu Leu Ser Pro Glu Leu Lys Glu Arg Phe Thr Arg Phe Ala Lys Ser 
145                 150                 155                 160 


Leu Gly Leu Lys Asp Asp Asn Ile Ile Phe Ser Val Pro Thr Asp Gln 
                165                 170                 175     


Cys Ile Asp Asn 
            180 


<210>  47
<211>  178
<212>  PRT
<213>  Rattus norvegicus

<400>  47

Gln Asp Ser Thr Gln Asn Leu Ile Pro Ala Pro Pro Leu Ile Ser Val 
1               5                   10                  15      


Pro Leu Gln Pro Gly Phe Trp Thr Glu Arg Phe Gln Gly Arg Trp Phe 
            20                  25                  30          


Val Val Gly Leu Ala Ala Asn Ala Val Gln Lys Glu Arg Gln Ser Arg 
        35                  40                  45              


Phe Thr Met Tyr Ser Thr Ile Tyr Glu Leu Gln Glu Asp Asn Ser Tyr 
    50                  55                  60                  


Asn Val Thr Ser Ile Leu Val Arg Gly Gln Gly Cys Arg Tyr Trp Ile 
65                  70                  75                  80  


Arg Thr Phe Val Pro Ser Ser Arg Pro Gly Gln Phe Thr Leu Gly Asn 
                85                  90                  95      


Ile His Ser Tyr Pro Gln Ile Gln Ser Tyr Asp Val Gln Val Ala Asp 
            100                 105                 110         


Thr Asp Tyr Asp Gln Phe Ala Met Val Phe Phe Gln Lys Thr Ser Glu 
        115                 120                 125             


Asn Lys Gln Tyr Phe Lys Val Thr Leu Tyr Gly Arg Thr Lys Gly Leu 
    130                 135                 140                 


Ser Asp Glu Leu Lys Glu Arg Phe Val Ser Phe Ala Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Lys Asp Asn Asn Ile Val Phe Ser Val Pro Thr Asp Gln Cys Ile 
                165                 170                 175     


Asp Asn 
        


<210>  48
<211>  178
<212>  PRT
<213>  Pan troglodytes

<400>  48

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe Gln Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Leu Ala Gly Asn Ala Ile Leu Arg Glu Asp Lys Asp Pro 
        35                  40                  45              


Gln Lys Met Tyr Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  


Asn Val Thr Ser Val Leu Phe Arg Lys Lys Lys Cys Asp Tyr Trp Ile 
65                  70                  75                  80  


Arg Thr Phe Val Pro Gly Arg Gln Pro Gly Glu Phe Thr Leu Gly Asn 
                85                  90                  95      


Ile Lys Ser Tyr Pro Gly Leu Thr Ser Tyr Leu Val Arg Val Val Ser 
            100                 105                 110         


Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Lys Val Ser Gln 
        115                 120                 125             


Asn Arg Glu Tyr Phe Lys Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Gln Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly 
        


<210>  49
<211>  180
<212>  PRT
<213>  Gorilla gorilla

<400>  49

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe Gln Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Leu Ala Gly Asn Ala Ile Leu Arg Glu Asp Lys Asp Pro 
        35                  40                  45              


Gln Lys Met Tyr Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  


Asn Val Thr Ser Val Leu Phe Arg Glu Lys Ala Gln Lys Cys Asp Tyr 
65                  70                  75                  80  


Trp Ile Arg Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu 
                85                  90                  95      


Gly Asn Ile Lys Ser Tyr Pro Gly Leu Thr Ser Tyr Leu Val Arg Val 
            100                 105                 110         


Val Ser Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Lys Val 
        115                 120                 125             


Ser Gln Asn Arg Glu Tyr Phe Lys Ile Thr Leu Tyr Gly Arg Thr Lys 
    130                 135                 140                 


Glu Leu Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser 
145                 150                 155                 160 


Leu Gly Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln 
                165                 170                 175     


Cys Ile Asp Gly 
            180 


<210>  50
<211>  178
<212>  PRT
<213>  Pongo pygmaeus

<400>  50

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe Gln Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Leu Ala Gly Asn Ala Ile Arg Arg Glu Asp Lys Asp Ser 
        35                  40                  45              


Gln Lys Met Tyr Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  


Asn Val Thr Ser Val Leu Phe Arg Lys Lys Lys Cys Asp Tyr Trp Ile 
65                  70                  75                  80  


Arg Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly Asn 
                85                  90                  95      


Thr Lys Gly Tyr Pro Gly Leu Thr Ser Tyr Leu Val Arg Val Val Ser 
            100                 105                 110         


Thr Asn Tyr Asn Gln Tyr Ala Met Val Phe Phe Lys Lys Val Ser Gln 
        115                 120                 125             


Asn Arg Glu Tyr Phe Lys Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asn His Ile Val Phe Pro Ala Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly 
        


<210>  51
<211>  178
<212>  PRT
<213>  Macacca mullatta

<400>  51

Gln Asp Ser Ser Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe Gln Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Leu Ser Gly Asn Ala Val Gly Arg Lys Asp Glu Ala Pro 
        35                  40                  45              


Leu Lys Met Tyr Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  


Asn Val Thr Ser Ile Leu Phe Arg Lys Glu Lys Cys Asp Tyr Trp Ile 
65                  70                  75                  80  


Arg Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly Asn 
                85                  90                  95      


Ile Gln Asn His Pro Gly Leu Thr Ser Tyr Val Val Arg Val Val Ser 
            100                 105                 110         


Thr Asn Tyr Lys Gln Tyr Ala Met Val Phe Phe Lys Lys Val Ser Gln 
        115                 120                 125             


Asn Lys Glu Tyr Phe Lys Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asn His Ile Val Phe Ser Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asn Gly 
        


<210>  52
<211>  178
<212>  PRT
<213>  Callithrix jacchus

<400>  52

Gln Asp Ser Pro Ser Pro Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe Gln Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Leu Ala Gly Asn Ala Ile Arg Arg Glu Asp Gln Asp Ser 
        35                  40                  45              


Leu Lys Met Tyr Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  


Asn Val Thr Ser Val Leu Phe Arg Lys Gly Lys Cys Asp Tyr Trp Ile 
65                  70                  75                  80  


Arg Thr Phe Val Pro Ser Ser Arg Pro Gly Glu Phe Lys Leu Gly Asn 
                85                  90                  95      


Ile Glu Ser His Pro Gly Leu Thr Ser Tyr Ile Val Arg Val Val Asn 
            100                 105                 110         


Thr Asp Tyr Lys Gln His Ala Met Val Phe Phe Met Lys Ala Ser His 
        115                 120                 125             


Asn Arg Lys Tyr Phe Lys Val Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Asp Leu Lys Glu Asn Phe Thr Ser Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Thr Glu Asn His Ile Ile Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly 
        


<210>  53
<211>  185
<212>  PRT
<213>  Ochotona princeps

<400>  53

Gln Glu Leu Thr Met Asp Pro Thr Pro Ser Pro Arg Leu Ile Pro Val 
1               5                   10                  15      


Pro Ser Leu Arg Lys Ile His Val Gln Lys Asn Phe Gln Ser Asp Gln 
            20                  25                  30          


Phe Gln Gly Lys Trp Tyr Val Val Gly Leu Ala Gly Asn Asn Ile His 
        35                  40                  45              


Asn Ser Asp Gln Glu His Gln Gln Met Tyr Ser Thr Thr Tyr Glu Leu 
    50                  55                  60                  


Lys Glu Asp Gly Ser Tyr Asn Val Thr Ser Thr Leu Leu Arg Asn Gln 
65                  70                  75                  80  


Gln Cys Asp His Trp Ile Arg Thr Phe Val Pro Gly Ser Lys Leu Gly 
                85                  90                  95      


His Phe Asn Leu Gly Asn Ile Lys Ser Tyr Pro Thr Leu Lys Ser Tyr 
            100                 105                 110         


Leu Ile Arg Val Val Thr Thr Asp Tyr Asn Gln Phe Ala Ile Val Phe 
        115                 120                 125             


Phe Arg Lys Val Tyr Lys Asn Asn Lys Lys Phe Phe Lys Ile Val Leu 
    130                 135                 140                 


Tyr Gly Arg Thr Lys Glu Leu Ser Pro Glu Leu Arg Gly Arg Phe Thr 
145                 150                 155                 160 


Ser Phe Ala Lys Thr Leu Gly Leu Thr Asp Asn His Ile Val Phe Pro 
                165                 170                 175     


Ala Pro Ile Gly Gln Cys Ile Asp Asp 
            180                 185 


<210>  54
<211>  178
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  54

Gln Asp Pro Thr Pro Lys Leu Ile Pro Ala Pro Ser Leu Arg Arg Val 
1               5                   10                  15      


Pro Leu Gln Arg Asn Phe Gln Asp Glu Gln Phe Gln Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Leu Ala Gly Asn Ala Val Gln Lys Arg Glu Glu Gly Gln 
        35                  40                  45              


Glu Pro Met Tyr Ser Thr Thr Tyr Glu Leu Asn Glu Asp Arg Ser Phe 
    50                  55                  60                  


Asn Val Thr Ser Thr Leu Leu Arg Asp Gln Arg Cys Asp His Trp Ile 
65                  70                  75                  80  


Arg Thr Phe Val Pro Thr Ser Arg Pro Gly Gln Tyr Asn Leu Gly Asn 
                85                  90                  95      


Ile Lys Ser Tyr Pro Gly Val Lys Asn Tyr Ile Val Arg Val Val Ala 
            100                 105                 110         


Thr Asp Tyr Ser Gln Tyr Ala Met Met Phe Phe Arg Lys Gly Ser Arg 
        115                 120                 125             


Asn Lys Gln Phe Phe Lys Thr Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Ser Pro Glu Leu Arg Glu Arg Phe Thr Arg Phe Ala Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Asp Asp Arg Ile Val Phe Pro Thr Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Asp 
        


<210>  55
<211>  179
<212>  PRT
<213>  Bos taurus

<400>  55

Arg Ser Ser Ser Ser Arg Leu Leu Arg Ala Pro Pro Leu Ser Arg Ile 
1               5                   10                  15      


Pro Leu Gln Pro Asn Phe Gln Ala Asp Gln Phe Gln Gly Lys Trp Tyr 
            20                  25                  30          


Thr Val Gly Val Ala Gly Asn Ala Ile Lys Lys Glu Glu Gln Asp Pro 
        35                  40                  45              


Leu Lys Met Tyr Ser Ser Asn Tyr Glu Leu Lys Glu Asp Gly Ser Tyr 
    50                  55                  60                  


Asn Val Thr Ser Ile Leu Leu Lys Asp Asp Leu Cys Asp Tyr Trp Ile 
65                  70                  75                  80  


Arg Thr Phe Val Pro Ser Ser Gln Pro Gly Gln Phe Thr Leu Gly Asn 
                85                  90                  95      


Ile Lys Ser Tyr Arg Gly Ile Arg Ser Tyr Thr Val Arg Val Val Asn 
            100                 105                 110         


Thr Asp Tyr Asn Gln Phe Ala Ile Val Tyr Phe Lys Lys Val Gln Arg 
        115                 120                 125             


Lys Lys Thr Tyr Phe Lys Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Pro Glu Val Arg Glu Asn Phe Ile Asn Phe Ala Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Thr Asp Asp His Ile Val Phe Thr Val Pro Ile Asp Arg Cys Ile 
                165                 170                 175     


Asp Asp Gln 
            


<210>  56
<211>  179
<212>  PRT
<213>  Sus scrofa

<400>  56

Gln Gly Thr Ile Pro Asn Trp Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Pro Asn Phe Gln Ala Asp Gln Phe Gln Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Leu Ala Gly Asn Ala Val Lys Lys Glu Glu Gln Gly Arg 
        35                  40                  45              


Phe Lys Met Tyr Thr Thr Thr Tyr Glu Leu Lys Glu Asp Gly Ser Tyr 
    50                  55                  60                  


Asn Val Ile Ser Thr Leu Leu Arg Gly Gln Leu Cys Asp Asn Trp Ile 
65                  70                  75                  80  


Arg Thr Phe Val Pro Ser Leu Gln Pro Gly Gln Phe Lys Leu Gly Asp 
                85                  90                  95      


Ile Lys Lys Tyr Ser Gly Leu Gln Ser Tyr Val Val Arg Val Val Ser 
            100                 105                 110         


Thr Asn Tyr Ser Gln Phe Ala Ile Val Phe Phe Lys Lys Val Ser Asn 
        115                 120                 125             


Asn Gln Glu Tyr Phe Lys Thr Thr Leu Tyr Gly Arg Thr Lys Val Leu 
    130                 135                 140                 


Ser Pro Glu Leu Lys Glu Asn Phe Val Arg Phe Ala Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Ser Asp Asp Asn Ile Ile Phe Pro Val Ala Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly Gln 
            


<210>  57
<211>  179
<212>  PRT
<213>  Tursiops truncatus

<400>  57

Gln Asp Ser Thr Pro Asn Leu Ile Pro Ala Pro Pro Leu Phe Arg Val 
1               5                   10                  15      


Pro Leu Gln Pro Asn Phe Gln Pro Asp Gln Phe Gln Gly Lys Trp Tyr 
            20                  25                  30          


Ile Val Gly Leu Ala Gly Asn Ala Phe Lys Lys Glu Lys Gln Gly Gln 
        35                  40                  45              


Phe Lys Met Tyr Ala Thr Thr Tyr Glu Leu Lys Glu Asp Arg Ser Tyr 
    50                  55                  60                  


Asn Val Thr Ser Ala Leu Leu Arg Asp Glu Arg Cys Asp His Trp Ile 
65                  70                  75                  80  


Arg Thr Phe Val Pro Ser Ser Arg Pro Gly Gln Phe Thr Leu Gly Asn 
                85                  90                  95      


Ile Lys Gly Phe Pro Gly Val Gln Ser Tyr Thr Val Arg Val Ala Thr 
            100                 105                 110         


Thr Asn Tyr Asn Gln Phe Ala Ile Val Tyr Phe Lys Lys Val Tyr Lys 
        115                 120                 125             


Asn Gln Glu Tyr Phe Lys Thr Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Pro Gln Leu Lys Glu Asn Phe Ile His Phe Ala Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Thr Asp Glu Tyr Ile Leu Phe Pro Val Pro Ile Asp Lys Cys Ile 
                165                 170                 175     


Asp Asp Gln 
            


<210>  58
<211>  179
<212>  PRT
<213>  Equus caballus

<400>  58

Arg Asp Pro Ala Pro Lys Leu Ile Pro Ala Pro Pro Leu Asp Arg Val 
1               5                   10                  15      


Pro Leu Gln Pro Asp Phe Lys Asp Asp Gln Phe Gln Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Val Ala Gly Asn Ala Phe Lys Lys Glu Glu Gln Gly Gln 
        35                  40                  45              


Phe Thr Met Tyr Thr Thr Thr Tyr Glu Leu Lys Glu Asp His Ser Tyr 
    50                  55                  60                  


Asn Val Thr Ser Ile Leu Leu Arg Asp Gln Asn Cys Asp His Trp Ile 
65                  70                  75                  80  


Arg Thr Phe Ile Pro Ser Ser Gln Pro Gly Gln Phe Asn Leu Gly Asp 
                85                  90                  95      


Ile Lys Arg Tyr Phe Gly Val Gln Ser Tyr Ile Val Arg Val Ala Asp 
            100                 105                 110         


Thr Asp Tyr Asn Gln Phe Ala Ile Val Phe Phe Arg Lys Val Tyr Lys 
        115                 120                 125             


Asn Gln Glu Tyr Phe Lys Thr Thr Leu Tyr Arg Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Pro Glu Leu Arg Glu Lys Phe Ile Ser Phe Ala Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Thr Asp Asp His Ile Ile Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Glu Glu 
            


<210>  59
<211>  177
<212>  PRT
<213>  Microcebus murinus

<400>  59

Gln Asp Ser Lys Glu Lys Leu Ile Pro Ala Pro Pro Leu Leu Arg Val 
1               5                   10                  15      


Pro Leu Gln Pro Asp Phe Gln Asp Asp Gln Phe Gln Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Leu Ala Gly Asn Ala Val Ser Lys Glu Glu Gln Gly Gln 
        35                  40                  45              


Phe Thr Met Tyr Thr Thr Thr Tyr Glu Leu Lys Asp His Ser Tyr Asn 
    50                  55                  60                  


Val Thr Ser Thr Leu Leu Arg Asn Gly Lys Cys Asp Tyr Trp Ile Arg 
65                  70                  75                  80  


Thr Phe Val Leu Thr Ser Gln Pro Gly Gln Phe Ala Leu Gly Asn Ile 
                85                  90                  95      


Asn Arg Tyr Pro Gly Ile Gln Ser Tyr Thr Val Arg Val Val Thr Thr 
            100                 105                 110         


Asn Tyr Asn Gln Phe Ala Ile Val Phe Phe Lys Lys Val Ser Glu Asn 
        115                 120                 125             


Lys Glu Tyr Phe Lys Thr Thr Leu Tyr Gly Arg Thr Lys Glu Leu Pro 
    130                 135                 140                 


Pro Glu Leu Lys Glu Asn Phe Ile Arg Phe Ala Lys Ser Leu Gly Leu 
145                 150                 155                 160 


Thr Glu Asp His Ile Ile Tyr Pro Val Pro Ile Asp Gln Cys Ile Asp 
                165                 170                 175     


Asp 
    


<210>  60
<211>  179
<212>  PRT
<213>  Loxodonta africana

<400>  60

Gln Thr His Ser Pro Thr Leu Ile Pro Ala Pro Pro Leu Leu Arg Val 
1               5                   10                  15      


Pro Leu Gln Pro Asp Phe Gln Asp Asp Lys Phe Gln Gly Lys Trp Tyr 
            20                  25                  30          


Val Ile Gly Leu Ala Gly Asn Ala Val Glu Lys Lys Glu Gln Gly Gln 
        35                  40                  45              


Phe Lys Met Tyr Thr Thr Thr Tyr Glu Leu Lys Glu Asp Gly Ser Tyr 
    50                  55                  60                  


Asn Val Thr Ser Thr Leu Leu Gln Glu Asp Gly Lys Cys Ser Tyr Trp 
65                  70                  75                  80  


Ile Arg Thr Phe Val Pro Ser Phe Gln Pro Gly Gln Phe Asn Leu Gly 
                85                  90                  95      


Asn Ile Lys Asn Phe Pro Gly Leu Gln Ser Tyr Thr Val Arg Val Thr 
            100                 105                 110         


Ala Thr Asn Tyr Asn Gln Phe Ala Ile Val Phe Phe Lys Lys Val Ser 
        115                 120                 125             


Lys Asn Gly Glu Tyr Phe Lys Thr Thr Leu Tyr Gly Arg Thr Lys Glu 
    130                 135                 140                 


Leu Thr Pro Glu Leu Lys Glu Arg Phe Ile Arg Phe Ala Lys Ser Leu 
145                 150                 155                 160 


Gly Leu Ser Asp His Ile Ile Phe Pro Val Pro Ile Asp Arg Cys Ile 
                165                 170                 175     


Asp Asp Ala 
            


<210>  61
<211>  178
<212>  PRT
<213>  Provacia capensis

<400>  61

Gln Glu Pro Thr Pro Leu Ile Pro Ala Pro Pro Leu Ser Ser Ile Pro 
1               5                   10                  15      


Leu Lys Pro Asn Phe His Asn Asp Lys Phe Gln Gly Lys Trp Tyr Val 
            20                  25                  30          


Val Gly Val Ala Gly Asn Ala Ile Thr Lys Glu Lys Asp Pro Ser Leu 
        35                  40                  45              


Met Tyr Thr Thr Thr Tyr Glu Leu Arg Asp Asp Gly Ser Tyr Asn Val 
    50                  55                  60                  


Thr Ser Thr Gln Phe Arg Glu Lys Ile Asn Cys Thr His Trp Thr Arg 
65                  70                  75                  80  


Thr Phe Val Pro Thr Ser Gln Pro Gly Gln Phe Ser Leu Gly Asn Ile 
                85                  90                  95      


Asp Lys Tyr Pro His Leu Ser Ser Tyr Thr Val Arg Val Thr Ala Thr 
            100                 105                 110         


Asn Tyr Asn Tyr Phe Ala Ile Val Tyr Phe Lys Lys Val Ser Lys Asn 
        115                 120                 125             


Gln Glu Tyr Phe Lys Thr Thr Leu Tyr Lys Arg Ile Lys Lys Leu Thr 
    130                 135                 140                 


His Gly Leu Lys Lys His Phe Ile Gln Phe Ala Lys Ser Leu Gly Leu 
145                 150                 155                 160 


Pro Asp Asn His Ile Thr Phe Leu Val Pro Thr Asp Arg Cys Ile Asp 
                165                 170                 175     


Asp Ala 
        


<210>  62
<211>  178
<212>  PRT
<213>  Canis familiaris

<400>  62

Gln Asp Ser Thr Pro Ser Leu Ile Pro Ala Pro Pro Pro Leu Lys Val 
1               5                   10                  15      


Pro Leu Gln Pro Asp Phe Gln His Asp Gln Phe Gln Gly Lys Trp Tyr 
            20                  25                  30          


Val Ile Gly Ile Ala Gly Asn Ile Leu Lys Lys Glu Gly His Gly Gln 
        35                  40                  45              


Leu Lys Met Tyr Thr Thr Thr Tyr Glu Leu Lys Asp Asp Gln Ser Tyr 
    50                  55                  60                  


Asn Val Thr Ser Thr Leu Leu Arg Asn Glu Arg Cys Asp Tyr Trp Asn 
65                  70                  75                  80  


Arg Asp Phe Val Pro Ser Phe Gln Pro Gly Gln Phe Ser Leu Gly Asp 
                85                  90                  95      


Ile Gln Leu Tyr Pro Gly Val Gln Ser Tyr Leu Val Gln Val Val Ala 
            100                 105                 110         


Thr Asn Tyr Asn Gln Tyr Ala Leu Val Tyr Phe Arg Lys Val Tyr Lys 
        115                 120                 125             


Ser Gln Glu Tyr Phe Lys Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Pro Leu Glu Leu Lys Lys Glu Phe Ile Arg Phe Ala Lys Ser Ile Gly 
145                 150                 155                 160 


Leu Thr Glu Asp His Ile Ile Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Glu 
        


<210>  63
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  signal peptide

<400>  63

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly 
            20  


<210>  64
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TEV protease site

<400>  64

Glu Asn Leu Tyr Phe Gln Lys 
1               5           


<210>  65
<211>  133
<212>  PRT
<213>  Homo sapiens

<400>  65

Asn Gln Glu Val Gln Ile Pro Leu Thr Glu Ser Tyr Cys Gly Pro Cys 
1               5                   10                  15      


Pro Lys Asn Trp Ile Cys Tyr Lys Asn Asn Cys Tyr Gln Phe Phe Asp 
            20                  25                  30          


Glu Ser Lys Asn Trp Tyr Glu Ser Gln Ala Ser Cys Met Ser Gln Asn 
        35                  40                  45              


Ala Ser Leu Leu Lys Val Tyr Ser Lys Glu Asp Gln Asp Leu Leu Lys 
    50                  55                  60                  


Leu Val Lys Ser Tyr His Trp Met Gly Leu Val His Ile Pro Thr Asn 
65                  70                  75                  80  


Gly Ser Trp Gln Trp Glu Asp Gly Ser Ile Leu Ser Pro Asn Leu Leu 
                85                  90                  95      


Thr Ile Ile Glu Met Gln Lys Gly Asp Cys Ala Leu Tyr Ala Ser Ser 
            100                 105                 110         


Phe Lys Gly Tyr Ile Glu Asn Cys Ser Thr Pro Asn Thr Tyr Ile Cys 
        115                 120                 125             


Met Gln Arg Thr Val 
    130             


<210>  66
<211>  129
<212>  PRT
<213>  Homo sapiens

<400>  66

Gln Ile Pro Leu Thr Glu Ser Tyr Cys Gly Pro Cys Pro Lys Asn Trp 
1               5                   10                  15      


Ile Cys Tyr Lys Asn Asn Cys Tyr Gln Phe Phe Asp Glu Ser Lys Asn 
            20                  25                  30          


Trp Tyr Glu Ser Gln Ala Ser Cys Met Ser Gln Asn Ala Ser Leu Leu 
        35                  40                  45              


Lys Val Tyr Ser Lys Glu Asp Gln Asp Leu Leu Lys Leu Val Lys Ser 
    50                  55                  60                  


Tyr His Trp Met Gly Leu Val His Ile Pro Thr Asn Gly Ser Trp Gln 
65                  70                  75                  80  


Trp Glu Asp Gly Ser Ile Leu Ser Pro Asn Leu Leu Thr Ile Ile Glu 
                85                  90                  95      


Met Gln Lys Gly Asp Cys Ala Leu Tyr Ala Ser Ser Phe Lys Gly Tyr 
            100                 105                 110         


Ile Glu Asn Cys Ser Thr Pro Asn Thr Tyr Ile Cys Met Gln Arg Thr 
        115                 120                 125             


Val 
    


<210>  67
<211>  489
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  exemplary construct

<400>  67

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Tyr Lys Asp Glu His His His His His His Gly 
            20                  25                  30          


Gly Ser Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser 
        35                  40                  45              


Lys Val Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe Gln Gly Lys 
    50                  55                  60                  


Trp Tyr Val Val Gly Leu Ala Gly Asn Ala Ile Leu Arg Glu Asp Lys 
65                  70                  75                  80  


Asp Pro Gln Lys Met Tyr Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys 
                85                  90                  95      


Ser Tyr Asn Val Thr Ser Val Leu Phe Arg Lys Lys Lys Cys Asp Tyr 
            100                 105                 110         


Trp Ile Arg Thr Phe Val Pro Gly Cys Gln Pro Gly Glu Phe Thr Leu 
        115                 120                 125             


Gly Asn Ile Lys Ser Tyr Pro Gly Leu Thr Ser Tyr Leu Val Arg Val 
    130                 135                 140                 


Val Ser Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Lys Val 
145                 150                 155                 160 


Ser Gln Asn Arg Glu Tyr Phe Lys Ile Thr Leu Tyr Gly Arg Thr Lys 
                165                 170                 175     


Glu Leu Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser 
            180                 185                 190         


Leu Gly Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln 
        195                 200                 205             


Cys Ile Asp Gly Gly Gly Ser Glu Asn Leu Tyr Phe Gln Lys Ser Gly 
    210                 215                 220                 


Gly Gly Ser Asn Gln Glu Val Gln Ile Pro Leu Thr Glu Ser Tyr Cys 
225                 230                 235                 240 


Gly Pro Cys Pro Lys Asn Trp Ile Cys Tyr Lys Asn Asn Cys Tyr Gln 
                245                 250                 255     


Phe Phe Asp Glu Ser Lys Asn Trp Tyr Glu Ser Gln Ala Ser Cys Met 
            260                 265                 270         


Ser Gln Asn Ala Ser Leu Leu Lys Val Tyr Ser Lys Glu Asp Gln Asp 
        275                 280                 285             


Leu Leu Lys Leu Val Lys Ser Tyr His Trp Met Gly Leu Val His Ile 
    290                 295                 300                 


Pro Thr Asn Gly Ser Trp Gln Trp Glu Asp Gly Ser Ile Leu Ser Pro 
305                 310                 315                 320 


Asn Leu Leu Thr Ile Ile Glu Met Gln Lys Gly Asp Cys Ala Leu Tyr 
                325                 330                 335     


Ala Ser Ser Phe Lys Gly Tyr Ile Glu Asn Cys Ser Thr Pro Asn Thr 
            340                 345                 350         


Tyr Ile Cys Met Gln Arg Thr Val Gln Ile Pro Leu Thr Glu Ser Tyr 
        355                 360                 365             


Cys Gly Pro Cys Pro Lys Asn Trp Ile Cys Tyr Lys Asn Asn Cys Tyr 
    370                 375                 380                 


Gln Phe Phe Asp Glu Ser Lys Asn Trp Tyr Glu Ser Gln Ala Ser Cys 
385                 390                 395                 400 


Met Ser Gln Asn Ala Ser Leu Leu Lys Val Tyr Ser Lys Glu Asp Gln 
                405                 410                 415     


Asp Leu Leu Lys Leu Val Lys Ser Tyr His Trp Met Gly Leu Val His 
            420                 425                 430         


Ile Pro Thr Asn Gly Ser Trp Gln Trp Glu Asp Gly Ser Ile Leu Ser 
        435                 440                 445             


Pro Asn Leu Leu Thr Ile Ile Glu Met Gln Lys Gly Asp Cys Ala Leu 
    450                 455                 460                 


Tyr Ala Ser Ser Phe Lys Gly Tyr Ile Glu Asn Cys Ser Thr Pro Asn 
465                 470                 475                 480 


Thr Tyr Ile Cys Met Gln Arg Thr Val 
                485                 


<210>  68
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  signal peptide

<400>  68

Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro Gly Ser 
1               5                   10                  15      


Thr Gly 
        


<210>  69
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flag tag

<400>  69

Asp Tyr Asp Glu 
1               


<210>  70
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  70

Ser Gly Gly Gly Ser 
1               5   


<210>  71
<211>  133
<212>  PRT
<213>  Mus musculus

<400>  71

Asn Lys Glu Val Pro Val Ser Ser Arg Glu Gly Tyr Cys Gly Pro Cys 
1               5                   10                  15      


Pro Asn Asn Trp Ile Cys His Arg Asn Asn Cys Tyr Gln Phe Phe Asn 
            20                  25                  30          


Glu Glu Lys Thr Trp Asn Gln Ser Gln Ala Ser Cys Leu Ser Gln Asn 
        35                  40                  45              


Ser Ser Leu Leu Lys Ile Tyr Ser Lys Glu Glu Gln Asp Phe Leu Lys 
    50                  55                  60                  


Leu Val Lys Ser Tyr His Trp Met Gly Leu Val Gln Ile Pro Ala Asn 
65                  70                  75                  80  


Gly Ser Trp Gln Trp Glu Asp Gly Ser Ser Leu Ser Tyr Asn Gln Leu 
                85                  90                  95      


Thr Leu Val Glu Ile Pro Lys Gly Ser Cys Ala Val Tyr Gly Ser Ser 
            100                 105                 110         


Phe Lys Ala Tyr Thr Glu Asp Cys Ala Asn Leu Asn Thr Tyr Ile Cys 
        115                 120                 125             


Met Lys Arg Ala Val 
    130             


<210>  72
<211>  129
<212>  PRT
<213>  Mus musculus

<400>  72

Pro Val Ser Ser Arg Glu Gly Tyr Cys Gly Pro Cys Pro Asn Asn Trp 
1               5                   10                  15      


Ile Cys His Arg Asn Asn Cys Tyr Gln Phe Phe Asn Glu Glu Lys Thr 
            20                  25                  30          


Trp Asn Gln Ser Gln Ala Ser Cys Leu Ser Gln Asn Ser Ser Leu Leu 
        35                  40                  45              


Lys Ile Tyr Ser Lys Glu Glu Gln Asp Phe Leu Lys Leu Val Lys Ser 
    50                  55                  60                  


Tyr His Trp Met Gly Leu Val Gln Ile Pro Ala Asn Gly Ser Trp Gln 
65                  70                  75                  80  


Trp Glu Asp Gly Ser Ser Leu Ser Tyr Asn Gln Leu Thr Leu Val Glu 
                85                  90                  95      


Ile Pro Lys Gly Ser Cys Ala Val Tyr Gly Ser Ser Phe Lys Ala Tyr 
            100                 105                 110         


Thr Glu Asp Cys Ala Asn Leu Asn Thr Tyr Ile Cys Met Lys Arg Ala 
        115                 120                 125             


Val 
    


<210>  73
<211>  486
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  exemplary construct

<400>  73

Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro Gly Ser 
1               5                   10                  15      


Thr Gly Asp Tyr Asp Glu His His His His His His Gly Gly Ser Gln 
            20                  25                  30          


Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val Pro 
        35                  40                  45              


Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe Gln Gly Lys Trp Tyr Val 
    50                  55                  60                  


Val Gly Leu Ala Gly Asn Ala Ile Leu Arg Glu Asp Lys Asp Pro Gln 
65                  70                  75                  80  


Lys Met Tyr Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr Asn 
                85                  90                  95      


Val Thr Ser Val Leu Phe Arg Lys Lys Lys Cys Asp Tyr Trp Ile Arg 
            100                 105                 110         


Thr Phe Val Pro Gly Cys Gln Pro Gly Glu Phe Thr Leu Gly Asn Ile 
        115                 120                 125             


Lys Ser Tyr Pro Gly Leu Thr Ser Tyr Leu Val Arg Val Val Ser Thr 
    130                 135                 140                 


Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Lys Val Ser Gln Asn 
145                 150                 155                 160 


Arg Glu Tyr Phe Lys Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu Thr 
                165                 170                 175     


Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly Leu 
            180                 185                 190         


Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile Asp 
        195                 200                 205             


Gly Gly Gly Ser Glu Asn Leu Tyr Phe Gln Lys Ser Gly Gly Gly Ser 
    210                 215                 220                 


Asn Lys Glu Val Pro Val Ser Ser Arg Glu Gly Tyr Cys Gly Pro Cys 
225                 230                 235                 240 


Pro Asn Asn Trp Ile Cys His Arg Asn Asn Cys Tyr Gln Phe Phe Asn 
                245                 250                 255     


Glu Glu Lys Thr Trp Asn Gln Ser Gln Ala Ser Cys Leu Ser Gln Asn 
            260                 265                 270         


Ser Ser Leu Leu Lys Ile Tyr Ser Lys Glu Glu Gln Asp Phe Leu Lys 
        275                 280                 285             


Leu Val Lys Ser Tyr His Trp Met Gly Leu Val Gln Ile Pro Ala Asn 
    290                 295                 300                 


Gly Ser Trp Gln Trp Glu Asp Gly Ser Ser Leu Ser Tyr Asn Gln Leu 
305                 310                 315                 320 


Thr Leu Val Glu Ile Pro Lys Gly Ser Cys Ala Val Tyr Gly Ser Ser 
                325                 330                 335     


Phe Lys Ala Tyr Thr Glu Asp Cys Ala Asn Leu Asn Thr Tyr Ile Cys 
            340                 345                 350         


Met Lys Arg Ala Val Pro Val Ser Ser Arg Glu Gly Tyr Cys Gly Pro 
        355                 360                 365             


Cys Pro Asn Asn Trp Ile Cys His Arg Asn Asn Cys Tyr Gln Phe Phe 
    370                 375                 380                 


Asn Glu Glu Lys Thr Trp Asn Gln Ser Gln Ala Ser Cys Leu Ser Gln 
385                 390                 395                 400 


Asn Ser Ser Leu Leu Lys Ile Tyr Ser Lys Glu Glu Gln Asp Phe Leu 
                405                 410                 415     


Lys Leu Val Lys Ser Tyr His Trp Met Gly Leu Val Gln Ile Pro Ala 
            420                 425                 430         


Asn Gly Ser Trp Gln Trp Glu Asp Gly Ser Ser Leu Ser Tyr Asn Gln 
        435                 440                 445             


Leu Thr Leu Val Glu Ile Pro Lys Gly Ser Cys Ala Val Tyr Gly Ser 
    450                 455                 460                 


Ser Phe Lys Ala Tyr Thr Glu Asp Cys Ala Asn Leu Asn Thr Tyr Ile 
465                 470                 475                 480 


Cys Met Lys Arg Ala Val 
                485     


<210>  74
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flag tag

<400>  74

Asp Tyr Lys Asp Asp Asp Asp Lys 
1               5               


<210>  75
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TEV scission site

<400>  75

Glu Asp Leu Tyr Phe Gln 
1               5       


<210>  76
<211>  216
<212>  PRT
<213>  Homo sapiens

<400>  76

Met Gly Trp Ile Arg Gly Arg Arg Ser Arg His Ser Trp Glu Met Ser 
1               5                   10                  15      


Glu Phe His Asn Tyr Asn Leu Asp Leu Lys Lys Ser Asp Phe Ser Thr 
            20                  25                  30          


Arg Trp Gln Lys Gln Arg Cys Pro Val Val Lys Ser Lys Cys Arg Glu 
        35                  40                  45              


Asn Ala Ser Pro Phe Phe Phe Cys Cys Phe Ile Ala Val Ala Met Gly 
    50                  55                  60                  


Ile Arg Phe Ile Ile Met Val Thr Ile Trp Ser Ala Val Phe Leu Asn 
65                  70                  75                  80  


Ser Leu Phe Asn Gln Glu Val Gln Ile Pro Leu Thr Glu Ser Tyr Cys 
                85                  90                  95      


Gly Pro Cys Pro Lys Asn Trp Ile Cys Tyr Lys Asn Asn Cys Tyr Gln 
            100                 105                 110         


Phe Phe Asp Glu Ser Lys Asn Trp Tyr Glu Ser Gln Ala Ser Cys Met 
        115                 120                 125             


Ser Gln Asn Ala Ser Leu Leu Lys Val Tyr Ser Lys Glu Asp Gln Asp 
    130                 135                 140                 


Leu Leu Lys Leu Val Lys Ser Tyr His Trp Met Gly Leu Val His Ile 
145                 150                 155                 160 


Pro Thr Asn Gly Ser Trp Gln Trp Glu Asp Gly Ser Ile Leu Ser Pro 
                165                 170                 175     


Asn Leu Leu Thr Ile Ile Glu Met Gln Lys Gly Asp Cys Ala Leu Tyr 
            180                 185                 190         


Ala Ser Ser Phe Lys Gly Tyr Ile Glu Asn Cys Ser Thr Pro Asn Thr 
        195                 200                 205             


Tyr Ile Cys Met Gln Arg Thr Val 
    210                 215     


<210>  77
<211>  177
<212>  PRT
<213>  Homo sapiens

<400>  77

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe Gln Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Leu Ala Gly Asn Ala Ile Leu Arg Glu Asp Lys Asp Pro 
        35                  40                  45              


Gln Lys Met Tyr Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  


Asn Val Thr Ser Val Leu Phe Arg Lys Lys Lys Cys Asp Tyr Trp Ile 
65                  70                  75                  80  


Arg Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly Asn 
                85                  90                  95      


Ile Lys Ser Tyr Pro Gly Leu Thr Ser Tyr Leu Val Arg Val Val Ser 
            100                 105                 110         


Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Lys Val Ser Gln 
        115                 120                 125             


Asn Arg Glu Tyr Phe Lys Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp 
    


<210>  78
<211>  551
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary construct

<400>  78

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Tyr Lys Asp Glu His His His His His His Gly 
            20                  25                  30          


Gly Ser Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser 
        35                  40                  45              


Lys Val Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe Gln Gly Lys 
    50                  55                  60                  


Trp Tyr Val Val Gly Leu Ala Gly Asn Ala Ile Leu Arg Glu Asp Lys 
65                  70                  75                  80  


Asp Pro Gln Lys Met Tyr Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys 
                85                  90                  95      


Ser Tyr Asn Val Thr Ser Val Leu Phe Arg Lys Lys Lys Cys Asp Tyr 
            100                 105                 110         


Trp Ile Arg Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu 
        115                 120                 125             


Gly Asn Ile Lys Ser Tyr Pro Gly Leu Thr Ser Tyr Leu Val Arg Val 
    130                 135                 140                 


Val Ser Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Lys Val 
145                 150                 155                 160 


Ser Gln Asn Arg Glu Tyr Phe Lys Ile Thr Leu Tyr Gly Arg Thr Lys 
                165                 170                 175     


Glu Leu Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser 
            180                 185                 190         


Leu Gly Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln 
        195                 200                 205             


Cys Ile Asp Gly Gly Gly Ser Glu Asn Leu Tyr Phe Gln Gly Ser Arg 
    210                 215                 220                 


Ser Ala Gly Ala His Ala Gly Trp Glu Thr Pro Glu Gly Cys Glu Gln 
225                 230                 235                 240 


Val Leu Thr Gly Lys Arg Leu Met Gln Cys Leu Pro Asn Pro Glu Asp 
                245                 250                 255     


Val Lys Met Ala Leu Glu Val Tyr Lys Leu Ser Leu Glu Ile Glu Gln 
            260                 265                 270         


Leu Glu Leu Gln Arg Asp Ser Ala Arg Gln Ser Thr Leu Asp Lys Glu 
        275                 280                 285             


Leu Asn Gln Glu Val Gln Ile Pro Leu Thr Glu Ser Tyr Cys Gly Pro 
    290                 295                 300                 


Cys Pro Lys Asn Trp Ile Cys Tyr Lys Asn Asn Cys Tyr Gln Phe Phe 
305                 310                 315                 320 


Asp Glu Ser Lys Asn Trp Tyr Glu Ser Gln Ala Ser Cys Met Ser Gln 
                325                 330                 335     


Asn Ala Ser Leu Leu Lys Val Tyr Ser Lys Glu Asp Gln Asp Leu Leu 
            340                 345                 350         


Lys Leu Val Lys Ser Tyr His Trp Met Gly Leu Val His Ile Pro Thr 
        355                 360                 365             


Asn Gly Ser Trp Gln Trp Glu Asp Gly Ser Ile Leu Ser Pro Asn Leu 
    370                 375                 380                 


Leu Thr Ile Ile Glu Met Gln Lys Gly Asp Cys Ala Leu Tyr Ala Ser 
385                 390                 395                 400 


Ser Phe Lys Gly Tyr Ile Glu Asn Cys Ser Thr Pro Asn Thr Tyr Ile 
                405                 410                 415     


Cys Met Gln Arg Thr Val Gln Ile Pro Leu Thr Glu Ser Tyr Cys Gly 
            420                 425                 430         


Pro Cys Pro Lys Asn Trp Ile Cys Tyr Lys Asn Asn Cys Tyr Gln Phe 
        435                 440                 445             


Phe Asp Glu Ser Lys Asn Trp Tyr Glu Ser Gln Ala Ser Cys Met Ser 
    450                 455                 460                 


Gln Asn Ala Ser Leu Leu Lys Val Tyr Ser Lys Glu Asp Gln Asp Leu 
465                 470                 475                 480 


Leu Lys Leu Val Lys Ser Tyr His Trp Met Gly Leu Val His Ile Pro 
                485                 490                 495     


Thr Asn Gly Ser Trp Gln Trp Glu Asp Gly Ser Ile Leu Ser Pro Asn 
            500                 505                 510         


Leu Leu Thr Ile Ile Glu Met Gln Lys Gly Asp Cys Ala Leu Tyr Ala 
        515                 520                 525             


Ser Ser Phe Lys Gly Tyr Ile Glu Asn Cys Ser Thr Pro Asn Thr Tyr 
    530                 535                 540                 


Ile Cys Met Gln Arg Thr Val 
545                 550     


<210>  79
<211>  123
<212>  PRT
<213>  Homo sapiens

<400>  79

Ser Tyr Cys Gly Pro Cys Pro Lys Asn Trp Ile Cys Tyr Lys Asn Asn 
1               5                   10                  15      


Cys Tyr Gln Phe Phe Asp Glu Ser Lys Asn Trp Tyr Glu Ser Gln Ala 
            20                  25                  30          


Ser Cys Met Ser Gln Asn Ala Ser Leu Leu Lys Val Tyr Ser Lys Glu 
        35                  40                  45              


Asp Gln Asp Leu Leu Lys Leu Val Lys Ser Tyr His Trp Met Gly Leu 
    50                  55                  60                  


Val His Ile Pro Thr Asn Gly Ser Trp Gln Trp Glu Asp Gly Ser Ile 
65                  70                  75                  80  


Leu Ser Pro Asn Leu Leu Thr Ile Ile Glu Met Gln Lys Gly Asp Cys 
                85                  90                  95      


Ala Leu Tyr Ala Ser Ser Phe Lys Gly Tyr Ile Glu Asn Cys Ser Thr 
            100                 105                 110         


Pro Asn Thr Tyr Ile Cys Met Gln Arg Thr Val 
        115                 120             


