                         SEQUENCE LISTING

<110>  The Regents of the University of Colorado, a body corporate
        
<120>  COMPOSITIONS AND METHODS FOR TREATMENT OF HOMOCYSTINURIA

<130>  2089.1003PCT2

<140>  PCT/US2016/XXXXX
<141>  2016-11-XX

<150>  US 14/935,690
<151>  2015-11-09

<160>  16    

<170>  PatentIn version 3.5

<210>  1
<211>  1656
<212>  DNA
<213>  Homo sapiens

<400>  1
atgccgtcag aaaccccgca ggcagaagtg ggtccgacgg gttgcccgca ccgtagcggt       60

ccgcattctg caaaaggcag tctggaaaaa ggttccccgg aagataaaga agccaaagaa      120

ccgctgtgga ttcgtccgga cgcaccgtca cgctgtacct ggcagctggg tcgtccggca      180

agcgaatctc cgcatcacca tacggctccg gcgaaaagtc cgaaaattct gccggatatc      240

ctgaagaaaa ttggtgacac cccgatggtt cgtatcaaca aaatcggcaa aaaattcggt      300

ctgaaatgcg aactgctggc taaatgtgaa tttttcaatg cgggcggttc cgtgaaagat      360

cgtatctcac tgcgcatgat tgaagatgct gaacgcgacg gcaccctgaa accgggtgat      420

acgattatcg aaccgacctc tggcaacacg ggtatcggtc tggcactggc ggcggcagtc      480

cgtggttatc gctgcattat cgtgatgccg gaaaaaatga gctctgaaaa agttgatgtc      540

ctgcgtgctc tgggcgcgga aattgttcgt accccgacga atgcccgctt cgacagtccg      600

gaatcccatg tgggtgttgc atggcgcctg aaaaacgaaa tcccgaattc gcacattctg      660

gatcagtatc gtaacgctag caatccgctg gcgcattacg ataccacggc cgacgaaatc      720

ctgcagcaat gtgatggcaa actggacatg ctggtcgctt ctgtgggtac cggcggtacc      780

attacgggca tcgcgcgtaa actgaaagaa aaatgcccgg gctgtcgcat tatcggtgtg      840

gatccggaag gcagtattct ggcggaaccg gaagaactga accagaccga acaaaccacg      900

tatgaagttg aaggcatcgg ttacgatttt attccgaccg tcctggatcg cacggtggtt      960

gacaaatggt tcaaaagcaa tgacgaagaa gcctttacct tcgcacgtat gctgatcgct     1020

caggaaggtc tgctgtgcgg tggttcagca ggttcgacgg tcgcagtggc agttaaagct     1080

gcgcaggaac tgcaagaagg tcaacgttgt gtcgtgattc tgccggattc tgttcgcaac     1140

tacatgacca aatttctgag tgaccgttgg atgctgcaaa aaggcttcct gaaagaagaa     1200

gatctgaccg agaaaaaacc gtggtggtgg cacctgcgcg tgcaggaact gggtctgtcc     1260

gcaccgctga ccgttctgcc gaccatcacg tgcggccata cgattgaaat cctgcgtgaa     1320

aaaggttttg atcaggcccc ggttgtcgac gaagcaggcg tgattctggg tatggttacc     1380

ctgggtaaca tgctgagttc cctgctggcg ggcaaagtgc aaccgagcga tcaggttggt     1440

aaagtcatct acaaacaatt caaacagatt cgtctgaccg atacgctggg ccgcctgtcg     1500

cacatcctgg aaatggacca tttcgcgctg gttgtgcacg aacagattca ataccatagc     1560

accggcaaat catcgcagcg ccaaatggtc tttggtgtcg tgacggccat tgatctgctg     1620

aatttcgtgg ccgcacaaga acgtgaccag aaataa                               1656


<210>  2
<211>  551
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Pro Ser Glu Thr Pro Gln Ala Glu Val Gly Pro Thr Gly Cys Pro 
1               5                   10                  15      


His Arg Ser Gly Pro His Ser Ala Lys Gly Ser Leu Glu Lys Gly Ser 
            20                  25                  30          


Pro Glu Asp Lys Glu Ala Lys Glu Pro Leu Trp Ile Arg Pro Asp Ala 
        35                  40                  45              


Pro Ser Arg Cys Thr Trp Gln Leu Gly Arg Pro Ala Ser Glu Ser Pro 
    50                  55                  60                  


His His His Thr Ala Pro Ala Lys Ser Pro Lys Ile Leu Pro Asp Ile 
65                  70                  75                  80  


Leu Lys Lys Ile Gly Asp Thr Pro Met Val Arg Ile Asn Lys Ile Gly 
                85                  90                  95      


Lys Lys Phe Gly Leu Lys Cys Glu Leu Leu Ala Lys Cys Glu Phe Phe 
            100                 105                 110         


Asn Ala Gly Gly Ser Val Lys Asp Arg Ile Ser Leu Arg Met Ile Glu 
        115                 120                 125             


Asp Ala Glu Arg Asp Gly Thr Leu Lys Pro Gly Asp Thr Ile Ile Glu 
    130                 135                 140                 


Pro Thr Ser Gly Asn Thr Gly Ile Gly Leu Ala Leu Ala Ala Ala Val 
145                 150                 155                 160 


Arg Gly Tyr Arg Cys Ile Ile Val Met Pro Glu Lys Met Ser Ser Glu 
                165                 170                 175     


Lys Val Asp Val Leu Arg Ala Leu Gly Ala Glu Ile Val Arg Thr Pro 
            180                 185                 190         


Thr Asn Ala Arg Phe Asp Ser Pro Glu Ser His Val Gly Val Ala Trp 
        195                 200                 205             


Arg Leu Lys Asn Glu Ile Pro Asn Ser His Ile Leu Asp Gln Tyr Arg 
    210                 215                 220                 


Asn Ala Ser Asn Pro Leu Ala His Tyr Asp Thr Thr Ala Asp Glu Ile 
225                 230                 235                 240 


Leu Gln Gln Cys Asp Gly Lys Leu Asp Met Leu Val Ala Ser Val Gly 
                245                 250                 255     


Thr Gly Gly Thr Ile Thr Gly Ile Ala Arg Lys Leu Lys Glu Lys Cys 
            260                 265                 270         


Pro Gly Cys Arg Ile Ile Gly Val Asp Pro Glu Gly Ser Ile Leu Ala 
        275                 280                 285             


Glu Pro Glu Glu Leu Asn Gln Thr Glu Gln Thr Thr Tyr Glu Val Glu 
    290                 295                 300                 


Gly Ile Gly Tyr Asp Phe Ile Pro Thr Val Leu Asp Arg Thr Val Val 
305                 310                 315                 320 


Asp Lys Trp Phe Lys Ser Asn Asp Glu Glu Ala Phe Thr Phe Ala Arg 
                325                 330                 335     


Met Leu Ile Ala Gln Glu Gly Leu Leu Cys Gly Gly Ser Ala Gly Ser 
            340                 345                 350         


Thr Val Ala Val Ala Val Lys Ala Ala Gln Glu Leu Gln Glu Gly Gln 
        355                 360                 365             


Arg Cys Val Val Ile Leu Pro Asp Ser Val Arg Asn Tyr Met Thr Lys 
    370                 375                 380                 


Phe Leu Ser Asp Arg Trp Met Leu Gln Lys Gly Phe Leu Lys Glu Glu 
385                 390                 395                 400 


Asp Leu Thr Glu Lys Lys Pro Trp Trp Trp His Leu Arg Val Gln Glu 
                405                 410                 415     


Leu Gly Leu Ser Ala Pro Leu Thr Val Leu Pro Thr Ile Thr Cys Gly 
            420                 425                 430         


His Thr Ile Glu Ile Leu Arg Glu Lys Gly Phe Asp Gln Ala Pro Val 
        435                 440                 445             


Val Asp Glu Ala Gly Val Ile Leu Gly Met Val Thr Leu Gly Asn Met 
    450                 455                 460                 


Leu Ser Ser Leu Leu Ala Gly Lys Val Gln Pro Ser Asp Gln Val Gly 
465                 470                 475                 480 


Lys Val Ile Tyr Lys Gln Phe Lys Gln Ile Arg Leu Thr Asp Thr Leu 
                485                 490                 495     


Gly Arg Leu Ser His Ile Leu Glu Met Asp His Phe Ala Leu Val Val 
            500                 505                 510         


His Glu Gln Ile Gln Tyr His Ser Thr Gly Lys Ser Ser Gln Arg Gln 
        515                 520                 525             


Met Val Phe Gly Val Val Thr Ala Ile Asp Leu Leu Asn Phe Val Ala 
    530                 535                 540                 


Ala Gln Glu Arg Asp Gln Lys 
545                 550     


<210>  3
<211>  413
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3

Met Pro Ser Glu Thr Pro Gln Ala Glu Val Gly Pro Thr Gly Cys Pro 
1               5                   10                  15      


His Arg Ser Gly Pro His Ser Ala Lys Gly Ser Leu Glu Lys Gly Ser 
            20                  25                  30          


Pro Glu Asp Lys Glu Ala Lys Glu Pro Leu Trp Ile Arg Pro Asp Ala 
        35                  40                  45              


Pro Ser Arg Cys Thr Trp Gln Leu Gly Arg Pro Ala Ser Glu Ser Pro 
    50                  55                  60                  


His His His Thr Ala Pro Ala Lys Ser Pro Lys Ile Leu Pro Asp Ile 
65                  70                  75                  80  


Leu Lys Lys Ile Gly Asp Thr Pro Met Val Arg Ile Asn Lys Ile Gly 
                85                  90                  95      


Lys Lys Phe Gly Leu Lys Cys Glu Leu Leu Ala Lys Cys Glu Phe Phe 
            100                 105                 110         


Asn Ala Gly Gly Ser Val Lys Asp Arg Ile Ser Leu Arg Met Ile Glu 
        115                 120                 125             


Asp Ala Glu Arg Asp Gly Thr Leu Lys Pro Gly Asp Thr Ile Ile Glu 
    130                 135                 140                 


Pro Thr Ser Gly Asn Thr Gly Ile Gly Leu Ala Leu Ala Ala Ala Val 
145                 150                 155                 160 


Arg Gly Tyr Arg Cys Ile Ile Val Met Pro Glu Lys Met Ser Ser Glu 
                165                 170                 175     


Lys Val Asp Val Leu Arg Ala Leu Gly Ala Glu Ile Val Arg Thr Pro 
            180                 185                 190         


Thr Asn Ala Arg Phe Asp Ser Pro Glu Ser His Val Gly Val Ala Trp 
        195                 200                 205             


Arg Leu Lys Asn Glu Ile Pro Asn Ser His Ile Leu Asp Gln Tyr Arg 
    210                 215                 220                 


Asn Ala Ser Asn Pro Leu Ala His Tyr Asp Thr Thr Ala Asp Glu Ile 
225                 230                 235                 240 


Leu Gln Gln Cys Asp Gly Lys Leu Asp Met Leu Val Ala Ser Val Gly 
                245                 250                 255     


Thr Gly Gly Thr Ile Thr Gly Ile Ala Arg Lys Leu Lys Glu Lys Cys 
            260                 265                 270         


Pro Gly Cys Arg Ile Ile Gly Val Asp Pro Glu Gly Ser Ile Leu Ala 
        275                 280                 285             


Glu Pro Glu Glu Leu Asn Gln Thr Glu Gln Thr Thr Tyr Glu Val Glu 
    290                 295                 300                 


Gly Ile Gly Tyr Asp Phe Ile Pro Thr Val Leu Asp Arg Thr Val Val 
305                 310                 315                 320 


Asp Lys Trp Phe Lys Ser Asn Asp Glu Glu Ala Phe Thr Phe Ala Arg 
                325                 330                 335     


Met Leu Ile Ala Gln Glu Gly Leu Leu Cys Gly Gly Ser Ala Gly Ser 
            340                 345                 350         


Thr Val Ala Val Ala Val Lys Ala Ala Gln Glu Leu Gln Glu Gly Gln 
        355                 360                 365             


Arg Cys Val Val Ile Leu Pro Asp Ser Val Arg Asn Tyr Met Thr Lys 
    370                 375                 380                 


Phe Leu Ser Asp Arg Trp Met Leu Gln Lys Gly Phe Leu Lys Glu Glu 
385                 390                 395                 400 


Asp Leu Thr Glu Lys Lys Pro Trp Trp Trp His Leu Arg 
                405                 410             


<210>  4
<211>  1242
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  4
atgccgtcag aaaccccgca ggcagaagtg ggtccgacgg gttgcccgca ccgtagcggt       60

ccgcattctg caaaaggcag tctggaaaaa ggttccccgg aagataaaga agccaaagaa      120

ccgctgtgga ttcgtccgga cgcaccgtca cgctgtacct ggcagctggg tcgtccggca      180

agcgaatctc cgcatcacca tacggctccg gcgaaaagtc cgaaaattct gccggatatc      240

ctgaagaaaa ttggtgacac cccgatggtt cgtatcaaca aaatcggcaa aaaattcggt      300

ctgaaatgcg aactgctggc taaatgtgaa tttttcaatg cgggcggttc cgtgaaagat      360

cgtatctcac tgcgcatgat tgaagatgct gaacgcgacg gcaccctgaa accgggtgat      420

acgattatcg aaccgacctc tggcaacacg ggtatcggtc tggcactggc ggcggcagtc      480

cgtggttatc gctgcattat cgtgatgccg gaaaaaatga gctctgaaaa agttgatgtc      540

ctgcgtgctc tgggcgcgga aattgttcgt accccgacga atgcccgctt cgacagtccg      600

gaatcccatg tgggtgttgc atggcgcctg aaaaacgaaa tcccgaattc gcacattctg      660

gatcagtatc gtaacgctag caatccgctg gcgcattacg ataccacggc cgacgaaatc      720

ctgcagcaat gtgatggcaa actggacatg ctggtcgctt ctgtgggtac cggcggtacc      780

attacgggca tcgcgcgtaa actgaaagaa aaatgcccgg gctgtcgcat tatcggtgtg      840

gatccggaag gcagtattct ggcggaaccg gaagaactga accagaccga acaaaccacg      900

tatgaagttg aaggcatcgg ttacgatttt attccgaccg tcctggatcg cacggtggtt      960

gacaaatggt tcaaaagcaa tgacgaagaa gcctttacct tcgcacgtat gctgatcgct     1020

caggaaggtc tgctgtgcgg tggttcagca ggttcgacgg tcgcagtggc agttaaagct     1080

gcgcaggaac tgcaagaagg tcaacgttgt gtcgtgattc tgccggattc tgttcgcaac     1140

tacatgacca aatttctgag tgaccgttgg atgctgcaaa aaggcttcct gaaagaagaa     1200

gatctgaccg agaaaaaacc gtggtggtgg cacctgcgct aa                        1242


<210>  5
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  5
cgtagaattc acctttgccc gcatgctgat                                        30


<210>  6
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  6
tacgggtacc tcaacggagg tgccaccacc agggc                                  35


<210>  7
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  7
agtcgcccat ggcgtcagaa accccgcag                                         29


<210>  8
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  8
atcgcgctcg agttagcgca ggtgccacca c                                      31


<210>  9
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  9
ggagatatac catgccgtca gaaaccccgc                                        30


<210>  10
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  10
gcggggtttc tgacggcatg gtatatctcc                                        30


<210>  11
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  11
tgggtccgac gggtagcccg cac                                               23


<210>  12
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  12
gtgcgggcta cccgtcggac cca                                               23


<210>  13
<211>  413
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Truncated human C15S mutant CBS polypeptide

<400>  13

Met Pro Ser Glu Thr Pro Gln Ala Glu Val Gly Pro Thr Gly Ser Pro 
1               5                   10                  15      


His Arg Ser Gly Pro His Ser Ala Lys Gly Ser Leu Glu Lys Gly Ser 
            20                  25                  30          


Pro Glu Asp Lys Glu Ala Lys Glu Pro Leu Trp Ile Arg Pro Asp Ala 
        35                  40                  45              


Pro Ser Arg Cys Thr Trp Gln Leu Gly Arg Pro Ala Ser Glu Ser Pro 
    50                  55                  60                  


His His His Thr Ala Pro Ala Lys Ser Pro Lys Ile Leu Pro Asp Ile 
65                  70                  75                  80  


Leu Lys Lys Ile Gly Asp Thr Pro Met Val Arg Ile Asn Lys Ile Gly 
                85                  90                  95      


Lys Lys Phe Gly Leu Lys Cys Glu Leu Leu Ala Lys Cys Glu Phe Phe 
            100                 105                 110         


Asn Ala Gly Gly Ser Val Lys Asp Arg Ile Ser Leu Arg Met Ile Glu 
        115                 120                 125             


Asp Ala Glu Arg Asp Gly Thr Leu Lys Pro Gly Asp Thr Ile Ile Glu 
    130                 135                 140                 


Pro Thr Ser Gly Asn Thr Gly Ile Gly Leu Ala Leu Ala Ala Ala Val 
145                 150                 155                 160 


Arg Gly Tyr Arg Cys Ile Ile Val Met Pro Glu Lys Met Ser Ser Glu 
                165                 170                 175     


Lys Val Asp Val Leu Arg Ala Leu Gly Ala Glu Ile Val Arg Thr Pro 
            180                 185                 190         


Thr Asn Ala Arg Phe Asp Ser Pro Glu Ser His Val Gly Val Ala Trp 
        195                 200                 205             


Arg Leu Lys Asn Glu Ile Pro Asn Ser His Ile Leu Asp Gln Tyr Arg 
    210                 215                 220                 


Asn Ala Ser Asn Pro Leu Ala His Tyr Asp Thr Thr Ala Asp Glu Ile 
225                 230                 235                 240 


Leu Gln Gln Cys Asp Gly Lys Leu Asp Met Leu Val Ala Ser Val Gly 
                245                 250                 255     


Thr Gly Gly Thr Ile Thr Gly Ile Ala Arg Lys Leu Lys Glu Lys Cys 
            260                 265                 270         


Pro Gly Cys Arg Ile Ile Gly Val Asp Pro Glu Gly Ser Ile Leu Ala 
        275                 280                 285             


Glu Pro Glu Glu Leu Asn Gln Thr Glu Gln Thr Thr Tyr Glu Val Glu 
    290                 295                 300                 


Gly Ile Gly Tyr Asp Phe Ile Pro Thr Val Leu Asp Arg Thr Val Val 
305                 310                 315                 320 


Asp Lys Trp Phe Lys Ser Asn Asp Glu Glu Ala Phe Thr Phe Ala Arg 
                325                 330                 335     


Met Leu Ile Ala Gln Glu Gly Leu Leu Cys Gly Gly Ser Ala Gly Ser 
            340                 345                 350         


Thr Val Ala Val Ala Val Lys Ala Ala Gln Glu Leu Gln Glu Gly Gln 
        355                 360                 365             


Arg Cys Val Val Ile Leu Pro Asp Ser Val Arg Asn Tyr Met Thr Lys 
    370                 375                 380                 


Phe Leu Ser Asp Arg Trp Met Leu Gln Lys Gly Phe Leu Lys Glu Glu 
385                 390                 395                 400 


Asp Leu Thr Glu Lys Lys Pro Trp Trp Trp His Leu Arg 
                405                 410             


<210>  14
<211>  1242
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Truncated human C15S mutant CBS Nucleotide

<400>  14
atgccgtcag aaaccccgca ggcagaagtg ggtccgacgg gtagcccgca ccgtagcggt       60

ccgcattctg caaaaggcag tctggaaaaa ggttccccgg aagataaaga agccaaagaa      120

ccgctgtgga ttcgtccgga cgcaccgtca cgctgtacct ggcagctggg tcgtccggca      180

agcgaatctc cgcatcacca tacggctccg gcgaaaagtc cgaaaattct gccggatatc      240

ctgaagaaaa ttggtgacac cccgatggtt cgtatcaaca aaatcggcaa aaaattcggt      300

ctgaaatgcg aactgctggc taaatgtgaa tttttcaatg cgggcggttc cgtgaaagat      360

cgtatctcac tgcgcatgat tgaagatgct gaacgcgacg gcaccctgaa accgggtgat      420

acgattatcg aaccgacctc tggcaacacg ggtatcggtc tggcactggc ggcggcagtc      480

cgtggttatc gctgcattat cgtgatgccg gaaaaaatga gctctgaaaa agttgatgtc      540

ctgcgtgctc tgggcgcgga aattgttcgt accccgacga atgcccgctt cgacagtccg      600

gaatcccatg tgggtgttgc atggcgcctg aaaaacgaaa tcccgaattc gcacattctg      660

gatcagtatc gtaacgctag caatccgctg gcgcattacg ataccacggc cgacgaaatc      720

ctgcagcaat gtgatggcaa actggacatg ctggtcgctt ctgtgggtac cggcggtacc      780

attacgggca tcgcgcgtaa actgaaagaa aaatgcccgg gctgtcgcat tatcggtgtg      840

gatccggaag gcagtattct ggcggaaccg gaagaactga accagaccga acaaaccacg      900

tatgaagttg aaggcatcgg ttacgatttt attccgaccg tcctggatcg cacggtggtt      960

gacaaatggt tcaaaagcaa tgacgaagaa gcctttacct tcgcacgtat gctgatcgct     1020

caggaaggtc tgctgtgcgg tggttcagca ggttcgacgg tcgcagtggc agttaaagct     1080

gcgcaggaac tgcaagaagg tcaacgttgt gtcgtgattc tgccggattc tgttcgcaac     1140

tacatgacca aatttctgag tgaccgttgg atgctgcaaa aaggcttcct gaaagaagaa     1200

gatctgaccg agaaaaaacc gtggtggtgg cacctgcgct aa                        1242


<210>  15
<211>  1656
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Full length human C15S mutant CBS nucleotide

<400>  15
atgccgtcag aaaccccgca ggcagaagtg ggtccgacgg gtagcccgca ccgtagcggt       60

ccgcattctg caaaaggcag tctggaaaaa ggttccccgg aagataaaga agccaaagaa      120

ccgctgtgga ttcgtccgga cgcaccgtca cgctgtacct ggcagctggg tcgtccggca      180

agcgaatctc cgcatcacca tacggctccg gcgaaaagtc cgaaaattct gccggatatc      240

ctgaagaaaa ttggtgacac cccgatggtt cgtatcaaca aaatcggcaa aaaattcggt      300

ctgaaatgcg aactgctggc taaatgtgaa tttttcaatg cgggcggttc cgtgaaagat      360

cgtatctcac tgcgcatgat tgaagatgct gaacgcgacg gcaccctgaa accgggtgat      420

acgattatcg aaccgacctc tggcaacacg ggtatcggtc tggcactggc ggcggcagtc      480

cgtggttatc gctgcattat cgtgatgccg gaaaaaatga gctctgaaaa agttgatgtc      540

ctgcgtgctc tgggcgcgga aattgttcgt accccgacga atgcccgctt cgacagtccg      600

gaatcccatg tgggtgttgc atggcgcctg aaaaacgaaa tcccgaattc gcacattctg      660

gatcagtatc gtaacgctag caatccgctg gcgcattacg ataccacggc cgacgaaatc      720

ctgcagcaat gtgatggcaa actggacatg ctggtcgctt ctgtgggtac cggcggtacc      780

attacgggca tcgcgcgtaa actgaaagaa aaatgcccgg gctgtcgcat tatcggtgtg      840

gatccggaag gcagtattct ggcggaaccg gaagaactga accagaccga acaaaccacg      900

tatgaagttg aaggcatcgg ttacgatttt attccgaccg tcctggatcg cacggtggtt      960

gacaaatggt tcaaaagcaa tgacgaagaa gcctttacct tcgcacgtat gctgatcgct     1020

caggaaggtc tgctgtgcgg tggttcagca ggttcgacgg tcgcagtggc agttaaagct     1080

gcgcaggaac tgcaagaagg tcaacgttgt gtcgtgattc tgccggattc tgttcgcaac     1140

tacatgacca aatttctgag tgaccgttgg atgctgcaaa aaggcttcct gaaagaagaa     1200

gatctgaccg agaaaaaacc gtggtggtgg cacctgcgcg tgcaggaact gggtctgtcc     1260

gcaccgctga ccgttctgcc gaccatcacg tgcggccata cgattgaaat cctgcgtgaa     1320

aaaggttttg atcaggcccc ggttgtcgac gaagcaggcg tgattctggg tatggttacc     1380

ctgggtaaca tgctgagttc cctgctggcg ggcaaagtgc aaccgagcga tcaggttggt     1440

aaagtcatct acaaacaatt caaacagatt cgtctgaccg atacgctggg ccgcctgtcg     1500

cacatcctgg aaatggacca tttcgcgctg gttgtgcacg aacagattca ataccatagc     1560

accggcaaat catcgcagcg ccaaatggtc tttggtgtcg tgacggccat tgatctgctg     1620

aatttcgtgg ccgcacaaga acgtgaccag aaataa                               1656


<210>  16
<211>  551
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Full length human C15S mutant CBS polypeptide

<400>  16

Met Pro Ser Glu Thr Pro Gln Ala Glu Val Gly Pro Thr Gly Ser Pro 
1               5                   10                  15      


His Arg Ser Gly Pro His Ser Ala Lys Gly Ser Leu Glu Lys Gly Ser 
            20                  25                  30          


Pro Glu Asp Lys Glu Ala Lys Glu Pro Leu Trp Ile Arg Pro Asp Ala 
        35                  40                  45              


Pro Ser Arg Cys Thr Trp Gln Leu Gly Arg Pro Ala Ser Glu Ser Pro 
    50                  55                  60                  


His His His Thr Ala Pro Ala Lys Ser Pro Lys Ile Leu Pro Asp Ile 
65                  70                  75                  80  


Leu Lys Lys Ile Gly Asp Thr Pro Met Val Arg Ile Asn Lys Ile Gly 
                85                  90                  95      


Lys Lys Phe Gly Leu Lys Cys Glu Leu Leu Ala Lys Cys Glu Phe Phe 
            100                 105                 110         


Asn Ala Gly Gly Ser Val Lys Asp Arg Ile Ser Leu Arg Met Ile Glu 
        115                 120                 125             


Asp Ala Glu Arg Asp Gly Thr Leu Lys Pro Gly Asp Thr Ile Ile Glu 
    130                 135                 140                 


Pro Thr Ser Gly Asn Thr Gly Ile Gly Leu Ala Leu Ala Ala Ala Val 
145                 150                 155                 160 


Arg Gly Tyr Arg Cys Ile Ile Val Met Pro Glu Lys Met Ser Ser Glu 
                165                 170                 175     


Lys Val Asp Val Leu Arg Ala Leu Gly Ala Glu Ile Val Arg Thr Pro 
            180                 185                 190         


Thr Asn Ala Arg Phe Asp Ser Pro Glu Ser His Val Gly Val Ala Trp 
        195                 200                 205             


Arg Leu Lys Asn Glu Ile Pro Asn Ser His Ile Leu Asp Gln Tyr Arg 
    210                 215                 220                 


Asn Ala Ser Asn Pro Leu Ala His Tyr Asp Thr Thr Ala Asp Glu Ile 
225                 230                 235                 240 


Leu Gln Gln Cys Asp Gly Lys Leu Asp Met Leu Val Ala Ser Val Gly 
                245                 250                 255     


Thr Gly Gly Thr Ile Thr Gly Ile Ala Arg Lys Leu Lys Glu Lys Cys 
            260                 265                 270         


Pro Gly Cys Arg Ile Ile Gly Val Asp Pro Glu Gly Ser Ile Leu Ala 
        275                 280                 285             


Glu Pro Glu Glu Leu Asn Gln Thr Glu Gln Thr Thr Tyr Glu Val Glu 
    290                 295                 300                 


Gly Ile Gly Tyr Asp Phe Ile Pro Thr Val Leu Asp Arg Thr Val Val 
305                 310                 315                 320 


Asp Lys Trp Phe Lys Ser Asn Asp Glu Glu Ala Phe Thr Phe Ala Arg 
                325                 330                 335     


Met Leu Ile Ala Gln Glu Gly Leu Leu Cys Gly Gly Ser Ala Gly Ser 
            340                 345                 350         


Thr Val Ala Val Ala Val Lys Ala Ala Gln Glu Leu Gln Glu Gly Gln 
        355                 360                 365             


Arg Cys Val Val Ile Leu Pro Asp Ser Val Arg Asn Tyr Met Thr Lys 
    370                 375                 380                 


Phe Leu Ser Asp Arg Trp Met Leu Gln Lys Gly Phe Leu Lys Glu Glu 
385                 390                 395                 400 


Asp Leu Thr Glu Lys Lys Pro Trp Trp Trp His Leu Arg Val Gln Glu 
                405                 410                 415     


Leu Gly Leu Ser Ala Pro Leu Thr Val Leu Pro Thr Ile Thr Cys Gly 
            420                 425                 430         


His Thr Ile Glu Ile Leu Arg Glu Lys Gly Phe Asp Gln Ala Pro Val 
        435                 440                 445             


Val Asp Glu Ala Gly Val Ile Leu Gly Met Val Thr Leu Gly Asn Met 
    450                 455                 460                 


Leu Ser Ser Leu Leu Ala Gly Lys Val Gln Pro Ser Asp Gln Val Gly 
465                 470                 475                 480 


Lys Val Ile Tyr Lys Gln Phe Lys Gln Ile Arg Leu Thr Asp Thr Leu 
                485                 490                 495     


Gly Arg Leu Ser His Ile Leu Glu Met Asp His Phe Ala Leu Val Val 
            500                 505                 510         


His Glu Gln Ile Gln Tyr His Ser Thr Gly Lys Ser Ser Gln Arg Gln 
        515                 520                 525             


Met Val Phe Gly Val Val Thr Ala Ile Asp Leu Leu Asn Phe Val Ala 
    530                 535                 540                 


Ala Gln Glu Arg Asp Gln Lys 
545                 550     


