                         SEQUENCE LISTING

<110>  The Children's Hospital of Philadelphia
       The Government of the United States of America as 
       represented by the Secretary of the Department of Health and 
       Human Services
 
<120>  GLYPICAN 2 AS A CANCER MARKER AND THERAPEUTIC TARGET

<130>  CHOP.P0005WO

<140>  Unknown
<141>  2016-11-08

<150>  US 62/253,000
<151>  2015-11-09

<150>  US 62/350,976
<151>  2016-06-16

<160>  30    

<170>  PatentIn version 3.5

<210>  1
<211>  357
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  1
gaggtgcagc tggtggagac tgggggaggc gtggtcaagc ctggagggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt gactactaca tgagctggat ccgccaggct      120

ccagggaagg ggctggagtg ggtttcatac attagtagta gtggtagtac catatactac      180

gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agctgaggac acggctgtgt attactgtgc gagagagagt      300

ggctacgatt acgtgtttga ctactggggc cagggaaccc tggtcgccgt ctcctca         357


<210>  2
<211>  119
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid

<400>  2

Glu Val Gln Leu Val Glu Thr Gly Gly Gly Val Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Ser Gly Tyr Asp Tyr Val Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Ala Val Ser Ser 
        115                 


<210>  3
<211>  324
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  3
gacatccaga tgacccagtc tccttccacc ctgtctgcat ttgtaggaga cagagtcacc       60

atcacttgcc gggccagtca gagtattagt agctggttgg cctggtatca gcaaaaacca      120

gggaaagccc ctaagctcct gatctatgct gcatccactt tgcaaagtgg ggtcccatca      180

aggttcagcg gcagtggatc tgggacagaa ttcactctca caatcagcag cctgcagcct      240

gaagattttg caacttatta ctgtcaacag cttaatagtt accctatcac cttcggccaa      300

gggacacgac tggagattaa acga                                             324


<210>  4
<211>  108
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid

<400>  4

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Phe Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Leu Asn Ser Tyr Pro Ile 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg 
            100                 105             


<210>  5
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid

<400>  5

Gly Phe Thr Phe Ser Asp Tyr Tyr 
1               5               


<210>  6
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid

<400>  6

Ile Ser Ser Ser Gly Ser Thr Ile 
1               5               


<210>  7
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid

<400>  7

Ala Arg Glu Ser Gly Tyr Asp Tyr Val Phe Asp Tyr 
1               5                   10          


<210>  8
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid

<400>  8

Gln Ser Ile Ser Ser Trp 
1               5       


<210>  9
<211>  3
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid

<400>  9

Ala Ala Ser 
1           


<210>  10
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid

<400>  10

Gln Gln Leu Asn Ser Tyr Pro Ile Thr 
1               5                   


<210>  11
<211>  345
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  11
caggtgcagc tggtgcagtc tggaggaggc ttgatccagc ctggggggtc cctgagactc       60

tcctgtgcag cctctgggtt caccgtcagt agcaactaca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagtt atttatagcg gtggtagcac atactacgca      180

gactccgtga agggccgatt caccatctcc agagacaatt ccaagaacac gctgtatctt      240

caaatgaaca gcctgagagc cgaggacacg gccgtgtatt actgtgcgag agattcgaat      300

gcttttgata tctggggcca agggacaatg gtcaccgtct cttca                      345


<210>  12
<211>  115
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid

<400>  12

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ser Asn 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Tyr Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Ser Asn Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  13
<211>  339
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  13
gaaattgtgc tgactcagtc tccactctcc ctgcccgtca cccctggaga gccggcctcc       60

atctcctgca ggtctagtca gagcctcctg tatagtaatg gatacaacta tttggattgg      120

tacctgcaga agccagggaa gtctccacag gtcctgatct atttgggttc taatcgggcc      180

tccggggtcc ccgacaggtt cagtggcagt ggatcaggca cagatttcac actgaaaatc      240

agcagagtgg aggctgagga tgttggggtt tattactgca tgcaagctct acaaactccg      300

atcaccttcg gccaagggac acgactggag attaaacga                             339


<210>  14
<211>  113
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid

<400>  14

Glu Ile Val Leu Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu Tyr Ser 
            20                  25                  30          


Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Lys Ser 
        35                  40                  45              


Pro Gln Val Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala 
                85                  90                  95      


Leu Gln Thr Pro Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
            100                 105                 110         


Arg 
    


<210>  15
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid

<400>  15

Gly Phe Thr Val Ser Ser Asn Tyr 
1               5               


<210>  16
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid

<400>  16

Val Ile Tyr Ser Gly Gly Ser Thr 
1               5               


<210>  17
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid

<400>  17

Ala Arg Asp Ser Asn Ala Phe Asp Ile 
1               5                   


<210>  18
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid

<400>  18

Gln Ser Leu Leu Tyr Ser Asn Gly Tyr Asn Tyr 
1               5                   10      


<210>  19
<211>  3
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid

<400>  19

Leu Gly Ser 
1           


<210>  20
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid

<400>  20

Met Gln Ala Leu Gln Thr Pro Ile Thr 
1               5                   


<210>  21
<211>  366
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  21
gaggtgcagc tggtgcagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttagc agctatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagct attagtggta gtggtggtag cacatactac      180

gcagactccg tgaagggccg cttcaccatc tccagagaca attccaagaa cacgctgtct      240

ctgcaaatgg acagcctgag acccgaggac acggccgtat attactgtgc gaaaagtcga      300

gatagtggga actaccttga tgcttttgat ttctggggcc aagggacaat ggtcaccgtc      360

tcttca                                                                 366


<210>  22
<211>  122
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid

<400>  22

Glu Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Ser 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Arg Asp Ser Gly Asn Tyr Leu Asp Ala Phe Asp Phe Trp 
            100                 105                 110         


Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120         


<210>  23
<211>  324
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  23
gacatccagt tgacccagtc tccttccacc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggccagtca gagtattagt agctggttgg cctggtatca gcagaaagca      120

gggaaagctc ctaggctcct gatctatgat gcctccactt tggaaagtgg agtcccatca      180

aggttcagcg gcactggatc tgggacatat ttcactctca ccatcagcag cctgcagcct      240

gaagattttg caacttatta ctgtcaacag tttaatagtt tcccgctcac tttcggcgga      300

gggaccaagg tggagatcaa acga                                             324


<210>  24
<211>  108
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid

<400>  24

Asp Ile Gln Leu Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Ala Gly Lys Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Thr Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Thr Gly Ser Gly Thr Tyr Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Phe Asn Ser Phe Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105             


<210>  25
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid

<400>  25

Gly Phe Thr Phe Ser Ser Tyr Ala 
1               5               


<210>  26
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid

<400>  26

Ile Ser Gly Ser Gly Gly Ser Thr 
1               5               


<210>  27
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid

<400>  27

Ala Lys Ser Arg Asp Ser Gly Asn Tyr Leu Asp Ala Phe Asp Phe 
1               5                   10                  15  


<210>  28
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid

<400>  28

Gln Ser Ile Ser Ser Trp 
1               5       


<210>  29
<211>  3
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid

<400>  29

Asp Ala Ser 
1           


<210>  30
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid

<400>  30

Gln Gln Phe Asn Ser Phe Pro Leu Thr 
1               5                   


