                         SEQUENCE LISTING

<110>  1)	B. G. NEGEV TECHNOLOGIES AND APPLICATIONS LTD., AT 
       BEN-GURION UNIVERSITY  AND 2)	THE NATIONAL INSTITUTE FOR 
       BIOTECHNOLOGY IN THE NEGEV LTD.
 
<120>  MEANS AND METHODS FOR REDUCING TUMORIGENICITY OF CANCER STEM 
       CELLS

<130>  VDC/007 PCT

<150>  US 62/253142
<151>  2015-11-10

<160>  94    

<170>  PatentIn version 3.5

<210>  1
<211>  283
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ala Val Pro Pro Thr Tyr Ala Asp Leu Gly Lys Ser Ala Arg Asp 
1               5                   10                  15      


Val Phe Thr Lys Gly Tyr Gly Phe Gly Leu Ile Lys Leu Asp Leu Lys 
            20                  25                  30          


Thr Lys Ser Glu Asn Gly Leu Glu Phe Thr Ser Ser Gly Ser Ala Asn 
        35                  40                  45              


Thr Glu Thr Thr Lys Val Thr Gly Ser Leu Glu Thr Lys Tyr Arg Trp 
    50                  55                  60                  


Thr Glu Tyr Gly Leu Thr Phe Thr Glu Lys Trp Asn Thr Asp Asn Thr 
65                  70                  75                  80  


Leu Gly Thr Glu Ile Thr Val Glu Asp Gln Leu Ala Arg Gly Leu Lys 
                85                  90                  95      


Leu Thr Phe Asp Ser Ser Phe Ser Pro Asn Thr Gly Lys Lys Asn Ala 
            100                 105                 110         


Lys Ile Lys Thr Gly Tyr Lys Arg Glu His Ile Asn Leu Gly Cys Asp 
        115                 120                 125             


Met Asp Phe Asp Ile Ala Gly Pro Ser Ile Arg Gly Ala Leu Val Leu 
    130                 135                 140                 


Gly Tyr Glu Gly Trp Leu Ala Gly Tyr Gln Met Asn Phe Glu Thr Ala 
145                 150                 155                 160 


Lys Ser Arg Val Thr Gln Ser Asn Phe Ala Val Gly Tyr Lys Thr Asp 
                165                 170                 175     


Glu Phe Gln Leu His Thr Asn Val Asn Asp Gly Thr Glu Phe Gly Gly 
            180                 185                 190         


Ser Ile Tyr Gln Lys Val Asn Lys Lys Leu Glu Thr Ala Val Asn Leu 
        195                 200                 205             


Ala Trp Thr Ala Gly Asn Ser Asn Thr Arg Phe Gly Ile Ala Ala Lys 
    210                 215                 220                 


Tyr Gln Ile Asp Pro Asp Ala Cys Phe Ser Ala Lys Val Asn Asn Ser 
225                 230                 235                 240 


Ser Leu Ile Gly Leu Gly Tyr Thr Gln Thr Leu Lys Pro Gly Ile Lys 
                245                 250                 255     


Leu Thr Leu Ser Ala Leu Leu Asp Gly Lys Asn Val Asn Ala Gly Gly 
            260                 265                 270         


His Lys Leu Gly Leu Gly Leu Glu Phe Gln Ala 
        275                 280             


<210>  2
<211>  852
<212>  DNA
<213>  Homo sapiens

<400>  2
atggctgtgc cacccacgta tgccgatctt ggcaaatctg ccagggatgt cttcaccaag       60

ggctatggat ttggcttaat aaagcttgat ttgaaaacaa aatctgagaa tggattggaa      120

tttacaagct caggctcagc caacactgag accaccaaag tgacgggcag tctggaaacc      180

aagtacagat ggactgagta cggcctgacg tttacagaga aatggaatac cgacaataca      240

ctaggcaccg agattactgt ggaagatcag cttgcacgtg gactgaagct gaccttcgat      300

tcatccttct cacctaacac tgggaaaaaa aatgctaaaa tcaagacagg gtacaagcgg      360

gagcacatta acctgggctg cgacatggat ttcgacattg ctgggccttc catccggggt      420

gctctggtgc taggttacga gggctggctg gccggctacc agatgaattt tgagactgca      480

aaatcccgag tgacccagag caactttgca gttggctaca agactgatga attccagctt      540

cacactaatg tgaatgacgg gacagagttt ggcggctcca tttaccagaa agtgaacaag      600

aagttggaga ccgctgtcaa tcttgcctgg acagcaggaa acagtaacac gcgcttcgga      660

atagcagcca agtatcagat tgaccctgac gcctgcttct cggctaaagt gaacaactcc      720

agcctgatag gtttaggata cactcagact ctaaagccag gtattaaact gacactgtca      780

gctcttctgg atggcaagaa cgtcaatgct ggtggccaca agcttggtct aggactggaa      840

tttcaagcat aa                                                          852


<210>  3
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  3
acacuaggca ccgagauua                                                    19


<210>  4
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  4
gggcuaugga uuuggcuua                                                    19


<210>  5
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  5
gcuuggucua ggacuggaa                                                    19


<210>  6
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  6
aagcugaccu ucgauucau                                                    19


<210>  7
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  7
gaaugacggg acagaguuu                                                    19


<210>  8
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  8
ucggaauagc agccaagua                                                    19


<210>  9
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  9
cucuucugga uggcaagaa                                                    19


<210>  10
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  10
gaauagcagc caaguaucag                                                   20


<210>  11
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  11
uaagccaaau ccauagccc                                                    19


<210>  12
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  12
uuccaguccu agaccaagc                                                    19


<210>  13
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  13
ugauacuugg cugcuauuc                                                    19


<210>  14
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  2'-O-methyl modification

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  2'-O-methyl modification

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  2'-O-methyl modification

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  2'-O-methyl modification

<400>  14
acacuaggca ccgagauua                                                    19


<210>  15
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'-O-methyl modification

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-O-methyl modification

<400>  15
uaaucucggu gccuagugu                                                    19


<210>  16
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  16
acactaggca ccgagatta                                                    19


<210>  17
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  17
gggctatgga tttggctta                                                    19


<210>  18
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  18
gcttggtcta ggactggaa                                                    19


<210>  19
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  19
aagctgacct tcgattcat                                                    19


<210>  20
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  20
gaatgacggg acagagttt                                                    19


<210>  21
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  21
tcggaatagc agccaagta                                                    19


<210>  22
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  22
ctcttctgga tggcaagaa                                                    19


<210>  23
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  23
gaatagcagc caagtatcag                                                   20


<210>  24
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  2'-O-methyl-modification

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  2'-O-methyl-modification

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  2'-O-methyl-modification

<400>  24
gcaaacaucc cagagguau                                                    19


<210>  25
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'-O-methyl-modification

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'-O-methyl-modification

<400>  25
auaccucugg gauguuugc                                                    19


<210>  26
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  26
actcttccag ccttccttcc                                                   20


<210>  27
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  27
tgttggcgta caggtctttg                                                   20


<210>  28
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  28
ccaaagtcct ggaggttgaa                                                   20


<210>  29
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  29
taactccagg ccatcacaca                                                   20


<210>  30
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  30
agtttccagc tgggagaaga g                                                 21


<210>  31
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  31
ctttgccatc ccatttctgt a                                                 21


<210>  32
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  32
ccagaaccta tgctggtgga                                                   20


<210>  33
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  33
ggctttttgg cttggttgac t                                                 21


<210>  34
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  34
aggaacaggt atcttggctc t                                                 21


<210>  35
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  35
ggggtgtaga ttggtgggaa                                                   20


<210>  36
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  36
gtagtggaaa accagcagcc                                                   20


<210>  37
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  37
cctcctcgtc gcagtagaaa                                                   20


<210>  38
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  38
tgcaaggatg acttggttac ag                                                22


<210>  39
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  39
cttctgcaac tgtgtctcca ac                                                22


<210>  40
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  40
aagctccagg atgaaaccaa c                                                 21


<210>  41
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  41
agcgactcaa tcttcctctc c                                                 21


<210>  42
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  42
tggaaggact catgaccaca                                                   20


<210>  43
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  43
atgatgttct ggagagcccc                                                   20


<210>  44
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  44
ggccatcttt tctgttgggg                                                   20


<210>  45
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  45
tcagcattga attccgccg                                                    19


<210>  46
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  46
ctgaccctgc actcaatcaa                                                   20


<210>  47
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  47
tccatcggaa ggactaggtg                                                   20


<210>  48
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  48
gtctcagtcc agcacgtttg                                                   20


<210>  49
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  49
gaaacgccgg gaatactgtg                                                   20


<210>  50
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  50
ccacatggga ctttttgacc                                                   20


<210>  51
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  51
ttactcggcg acagatttcc                                                   20


<210>  52
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  52
ctttgggtgc gacttgacg                                                    19


<210>  53
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  53
gtcgaccccg ctcctttt                                                     18


<210>  54
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  54
gcaggtggtt gagagtgctt                                                   20


<210>  55
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  55
gcacccgcct aagattcttc                                                   20


<210>  56
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  56
tccaaaatcg gatcaacaga c                                                 21


<210>  57
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  57
agagccacat ttggatgtca c                                                 21


<210>  58
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  58
tgggatttac aggcgtgagc cac                                               23


<210>  59
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  59
aagcaaagcc tcccaatccc aaac                                              24


<210>  60
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  60
agggatcaaa gcctggaaca                                                   20


<210>  61
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  61
ttggagcctg agacacgatt                                                   20


<210>  62
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  62
gaaacagcca tagagggcaa a                                                 21


<210>  63
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  63
tggttttcca gagtcttcag tga                                               23


<210>  64
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  64
gggctctccc atgcattcaa ac                                                22


<210>  65
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  65
caccttccct ccaaccagtt gc                                                22


<210>  66
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  66
gccgagatct cagccatatt                                                   20


<210>  67
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  67
atgtacttag aggtacaaat                                                   20


<210>  68
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  68
tgacagagga acgggggtat                                                   20


<210>  69
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  69
cggctgtgat caaatggcag                                                   20


<210>  70
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  70
agtggttctt ctgcgctact                                                   20


<210>  71
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  71
ctgctggaag gtaaactctg g                                                 21


<210>  72
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  72
acatacagtg attatttccc cgt                                               23


<210>  73
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  73
cgccccaaag atgaggagta                                                   20


<210>  74
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  74
aggagaggtc cgaggaggtg                                                   20


<210>  75
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  75
ctcagctcca cctccgatag                                                   20


<210>  76
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  76
ccatgcaggt tgacaccgtt g                                                 21


<210>  77
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  77
tcggcagact gattcaaata a                                                 21


<210>  78
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  78
tgaaatagct tagcggcaag a                                                 21


<210>  79
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  79
gtgaatcggg aacagttgtg t                                                 21


<210>  80
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  80
aagaggtggc tgcttcaaac                                                   20


<210>  81
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  81
agcctagatt ttcggccatc                                                   20


<210>  82
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  82
atgaatcagt ggatggcaca                                                   20


<210>  83
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  83
ccattgagtg cctggatctt                                                   20


<210>  84
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  84
ctcaggggcc tttggacatc                                                   20


<210>  85
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  85
caggcagtcg cagttttcac                                                   20


<210>  86
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  86
tcttacgagg agctgcagac                                                   20


<210>  87
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  87
tatccagctc cagagtctct                                                   20


<210>  88
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  88
ttcctgaggc acctgaagag                                                   20


<210>  89
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  89
ggtgttccat tttcatcatg acc                                               23


<210>  90
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  90
tagtgtgccc aaccatgagt                                                   20


<210>  91
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  91
ttgcattctt cactggacca                                                   20


<210>  92
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  92
aggttggctc tgactgtacc                                                   20


<210>  93
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  93
aaagctgttc cgtcccagta                                                   20


<210>  94
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  94
uaaucucggu gccuagugu                                                    19


