                         LISTADO DE SECUENCIAS

<110>  Centro Superior de Investigaciones Cientficas (CSIC)
 
<120>  MUTANTES DE LA PEROXIGENASA INESPECFICA CON ALTA ACTIVIDAD 
       MONOOXIGENASA Y SUS USOS

<130>  1641.1156

<150>  P201531641
<151>  2015-11-13

<160>  66    

<170>  PatentIn version 3.5

<210>  1
<211>  987
<212>  DNA
<213>  Agrocybe aegerita


<220>
<221>  CDS
<222>  (1)..(987)

<400>  1
gag cca gga tta cct cct ggt cct ctc gag aat agc tct gca aag ttg         48
Glu Pro Gly Leu Pro Pro Gly Pro Leu Glu Asn Ser Ser Ala Lys Leu           
1               5                   10                  15                

gtg aac gac gag gct cac cca tgg aag ccg ctt cga cct ggc gat att         96
Val Asn Asp Glu Ala His Pro Trp Lys Pro Leu Arg Pro Gly Asp Ile           
            20                  25                  30                    

cgt gga cct tgc cct ggt ctc aat act ctg gca tct cac ggg tac ctc        144
Arg Gly Pro Cys Pro Gly Leu Asn Thr Leu Ala Ser His Gly Tyr Leu           
        35                  40                  45                        

ccg aga aat ggc gtt gca acc ccg gtg caa ata ata aac gcg gtt cag        192
Pro Arg Asn Gly Val Ala Thr Pro Val Gln Ile Ile Asn Ala Val Gln           
    50                  55                  60                            

gaa gga ctc aat ttc gac aat caa gcc gca gtc ttc gcc aca tat gcg        240
Glu Gly Leu Asn Phe Asp Asn Gln Ala Ala Val Phe Ala Thr Tyr Ala           
65                  70                  75                  80            

gcc cac ctt gtg gac ggc aat ctc att acg gac ttg ctg agc atc gga        288
Ala His Leu Val Asp Gly Asn Leu Ile Thr Asp Leu Leu Ser Ile Gly           
                85                  90                  95                

cgc aag acg cgg ctc act ggg cct gat cca cca ccc ccc gct tcc gtt        336
Arg Lys Thr Arg Leu Thr Gly Pro Asp Pro Pro Pro Pro Ala Ser Val           
            100                 105                 110                   

ggt gga ctc aat gag cat ggc acc ttc gaa ggc gac gcc agt atg acc        384
Gly Gly Leu Asn Glu His Gly Thr Phe Glu Gly Asp Ala Ser Met Thr           
        115                 120                 125                       

cga ggt gac gca ttc ttt ggc aac aac cac gat ttc aat gag acg ctc        432
Arg Gly Asp Ala Phe Phe Gly Asn Asn His Asp Phe Asn Glu Thr Leu           
    130                 135                 140                           

ttc gaa cag ttg gtt gac tac agc aac cga ttt gga gga gga aaa tac        480
Phe Glu Gln Leu Val Asp Tyr Ser Asn Arg Phe Gly Gly Gly Lys Tyr           
145                 150                 155                 160           

aat ctt acc gtc gcg ggg gag ctc cgt ttc aag cgc att caa gac tcc        528
Asn Leu Thr Val Ala Gly Glu Leu Arg Phe Lys Arg Ile Gln Asp Ser           
                165                 170                 175               

att gcg acc aac ccc aat ttc tcc ttt gtt gac ttt agg ttc ttt act        576
Ile Ala Thr Asn Pro Asn Phe Ser Phe Val Asp Phe Arg Phe Phe Thr           
            180                 185                 190                   

gct tac ggc gag acc acc ttc ccc gcg aat ctt ttt gtg gat ggg cgc        624
Ala Tyr Gly Glu Thr Thr Phe Pro Ala Asn Leu Phe Val Asp Gly Arg           
        195                 200                 205                       

agg gac gac ggc cag cta gat atg gat gct gca cgg agt ttt ttc caa        672
Arg Asp Asp Gly Gln Leu Asp Met Asp Ala Ala Arg Ser Phe Phe Gln           
    210                 215                 220                           

ttc agc cgt atg cct gac gat ttc ttc cgc gca ccc agc ccg aga agt        720
Phe Ser Arg Met Pro Asp Asp Phe Phe Arg Ala Pro Ser Pro Arg Ser           
225                 230                 235                 240           

ggc aca gga gtc gag gta gtt ata cag gct cat cct atg cag ccc gga        768
Gly Thr Gly Val Glu Val Val Ile Gln Ala His Pro Met Gln Pro Gly           
                245                 250                 255               

aga aat gtc ggc aag atc aac agc tac acc gtc gac cca aca tcc tct        816
Arg Asn Val Gly Lys Ile Asn Ser Tyr Thr Val Asp Pro Thr Ser Ser           
            260                 265                 270                   

gac ttt tcc acc ccc tgc ttg atg tac gag aaa ttc gtc aac ata acg        864
Asp Phe Ser Thr Pro Cys Leu Met Tyr Glu Lys Phe Val Asn Ile Thr           
        275                 280                 285                       

gtc aag tca ctc tac ccg aat ccg acg gtg cag ctt cgc aaa gcc ctt        912
Val Lys Ser Leu Tyr Pro Asn Pro Thr Val Gln Leu Arg Lys Ala Leu           
    290                 295                 300                           

aat acg aat ctc gat ttc ttc ttc cag gga gtc gcc gct gga tgt acc        960
Asn Thr Asn Leu Asp Phe Phe Phe Gln Gly Val Ala Ala Gly Cys Thr           
305                 310                 315                 320           

cag gtc ttc cca tac ggg cga gat tga                                    987
Gln Val Phe Pro Tyr Gly Arg Asp                                           
                325                                                       


<210>  2
<211>  328
<212>  PRT
<213>  Agrocybe aegerita

<400>  2

Glu Pro Gly Leu Pro Pro Gly Pro Leu Glu Asn Ser Ser Ala Lys Leu 
1               5                   10                  15      


Val Asn Asp Glu Ala His Pro Trp Lys Pro Leu Arg Pro Gly Asp Ile 
            20                  25                  30          


Arg Gly Pro Cys Pro Gly Leu Asn Thr Leu Ala Ser His Gly Tyr Leu 
        35                  40                  45              


Pro Arg Asn Gly Val Ala Thr Pro Val Gln Ile Ile Asn Ala Val Gln 
    50                  55                  60                  


Glu Gly Leu Asn Phe Asp Asn Gln Ala Ala Val Phe Ala Thr Tyr Ala 
65                  70                  75                  80  


Ala His Leu Val Asp Gly Asn Leu Ile Thr Asp Leu Leu Ser Ile Gly 
                85                  90                  95      


Arg Lys Thr Arg Leu Thr Gly Pro Asp Pro Pro Pro Pro Ala Ser Val 
            100                 105                 110         


Gly Gly Leu Asn Glu His Gly Thr Phe Glu Gly Asp Ala Ser Met Thr 
        115                 120                 125             


Arg Gly Asp Ala Phe Phe Gly Asn Asn His Asp Phe Asn Glu Thr Leu 
    130                 135                 140                 


Phe Glu Gln Leu Val Asp Tyr Ser Asn Arg Phe Gly Gly Gly Lys Tyr 
145                 150                 155                 160 


Asn Leu Thr Val Ala Gly Glu Leu Arg Phe Lys Arg Ile Gln Asp Ser 
                165                 170                 175     


Ile Ala Thr Asn Pro Asn Phe Ser Phe Val Asp Phe Arg Phe Phe Thr 
            180                 185                 190         


Ala Tyr Gly Glu Thr Thr Phe Pro Ala Asn Leu Phe Val Asp Gly Arg 
        195                 200                 205             


Arg Asp Asp Gly Gln Leu Asp Met Asp Ala Ala Arg Ser Phe Phe Gln 
    210                 215                 220                 


Phe Ser Arg Met Pro Asp Asp Phe Phe Arg Ala Pro Ser Pro Arg Ser 
225                 230                 235                 240 


Gly Thr Gly Val Glu Val Val Ile Gln Ala His Pro Met Gln Pro Gly 
                245                 250                 255     


Arg Asn Val Gly Lys Ile Asn Ser Tyr Thr Val Asp Pro Thr Ser Ser 
            260                 265                 270         


Asp Phe Ser Thr Pro Cys Leu Met Tyr Glu Lys Phe Val Asn Ile Thr 
        275                 280                 285             


Val Lys Ser Leu Tyr Pro Asn Pro Thr Val Gln Leu Arg Lys Ala Leu 
    290                 295                 300                 


Asn Thr Asn Leu Asp Phe Phe Phe Gln Gly Val Ala Ala Gly Cys Thr 
305                 310                 315                 320 


Gln Val Phe Pro Tyr Gly Arg Asp 
                325             


<210>  3
<211>  1116
<212>  DNA
<213>  Agrocybe aegerita


<220>
<221>  CDS
<222>  (1)..(1113)

<220>
<221>  mat_peptide
<222>  (130)..(1116)

<400>  3
atg aaa tat ttt ccc ctg ttc cca acc ttg gtc tac gca gtg ggg gtc         48
Met Lys Tyr Phe Pro Leu Phe Pro Thr Leu Val Tyr Ala Val Gly Val           
            -40                 -35                 -30                   

gtt gct ttt cct gac tac gcc tca ttg gcc ggc ctc agc cag cag gaa         96
Val Ala Phe Pro Asp Tyr Ala Ser Leu Ala Gly Leu Ser Gln Gln Glu           
        -25                 -20                 -15                       

ttg gac gct ata atc cca aca ctc gag gcc cga gag cca gga tta cct        144
Leu Asp Ala Ile Ile Pro Thr Leu Glu Ala Arg Glu Pro Gly Leu Pro           
    -10                 -5              -1  1               5             

cct ggt cct ctc gag aat agc tct gca aag ttg gtg aac gac gag gct        192
Pro Gly Pro Leu Glu Asn Ser Ser Ala Lys Leu Val Asn Asp Glu Ala           
                10                  15                  20                

cac cca tgg aag ccg ctt cga cct ggc gat att cgt gga cct tgc cct        240
His Pro Trp Lys Pro Leu Arg Pro Gly Asp Ile Arg Gly Pro Cys Pro           
            25                  30                  35                    

ggt ctc aat act ctg gca tct cac ggg tac ctc ccg aga aat ggc gtt        288
Gly Leu Asn Thr Leu Ala Ser His Gly Tyr Leu Pro Arg Asn Gly Val           
        40                  45                  50                        

gca acc ccg gtg caa ata ata aac gcg gtt cag gaa gga ctc aat ttc        336
Ala Thr Pro Val Gln Ile Ile Asn Ala Val Gln Glu Gly Leu Asn Phe           
    55                  60                  65                            

gac aat caa gcc gca gtc ttc gcc aca tat gcg gcc cac ctt gtg gac        384
Asp Asn Gln Ala Ala Val Phe Ala Thr Tyr Ala Ala His Leu Val Asp           
70                  75                  80                  85            

ggc aat ctc att acg gac ttg ctg agc atc gga cgc aag acg cgg ctc        432
Gly Asn Leu Ile Thr Asp Leu Leu Ser Ile Gly Arg Lys Thr Arg Leu           
                90                  95                  100               

act ggg cct gat cca cca ccc ccc gct tcc gtt ggt gga ctc aat gag        480
Thr Gly Pro Asp Pro Pro Pro Pro Ala Ser Val Gly Gly Leu Asn Glu           
            105                 110                 115                   

cat ggc acc ttc gaa ggc gac gcc agt atg acc cga ggt gac gca ttc        528
His Gly Thr Phe Glu Gly Asp Ala Ser Met Thr Arg Gly Asp Ala Phe           
        120                 125                 130                       

ttt ggc aac aac cac gat ttc aat gag acg ctc ttc gaa cag ttg gtt        576
Phe Gly Asn Asn His Asp Phe Asn Glu Thr Leu Phe Glu Gln Leu Val           
    135                 140                 145                           

gac tac agc aac cga ttt gga gga gga aaa tac aat ctt acc gtc gcg        624
Asp Tyr Ser Asn Arg Phe Gly Gly Gly Lys Tyr Asn Leu Thr Val Ala           
150                 155                 160                 165           

ggg gag ctc cgt ttc aag cgc att caa gac tcc att gcg acc aac ccc        672
Gly Glu Leu Arg Phe Lys Arg Ile Gln Asp Ser Ile Ala Thr Asn Pro           
                170                 175                 180               

aat ttc tcc ttt gtt gac ttt agg ttc ttt act gct tac ggc gag acc        720
Asn Phe Ser Phe Val Asp Phe Arg Phe Phe Thr Ala Tyr Gly Glu Thr           
            185                 190                 195                   

acc ttc ccc gcg aat ctt ttt gtg gat ggg cgc agg gac gac ggc cag        768
Thr Phe Pro Ala Asn Leu Phe Val Asp Gly Arg Arg Asp Asp Gly Gln           
        200                 205                 210                       

cta gat atg gat gct gca cgg agt ttt ttc caa ttc agc cgt atg cct        816
Leu Asp Met Asp Ala Ala Arg Ser Phe Phe Gln Phe Ser Arg Met Pro           
    215                 220                 225                           

gac gat ttc ttc cgc gca ccc agc ccg aga agt ggc aca gga gtc gag        864
Asp Asp Phe Phe Arg Ala Pro Ser Pro Arg Ser Gly Thr Gly Val Glu           
230                 235                 240                 245           

gta gtt ata cag gct cat cct atg cag ccc gga aga aat gtc ggc aag        912
Val Val Ile Gln Ala His Pro Met Gln Pro Gly Arg Asn Val Gly Lys           
                250                 255                 260               

atc aac agc tac acc gtc gac cca aca tcc tct gac ttt tcc acc ccc        960
Ile Asn Ser Tyr Thr Val Asp Pro Thr Ser Ser Asp Phe Ser Thr Pro           
            265                 270                 275                   

tgc ttg atg tac gag aaa ttc gtc aac ata acg gtc aag tca ctc tac       1008
Cys Leu Met Tyr Glu Lys Phe Val Asn Ile Thr Val Lys Ser Leu Tyr           
        280                 285                 290                       

ccg aat ccg acg gtg cag ctt cgc aaa gcc ctt aat acg aat ctc gat       1056
Pro Asn Pro Thr Val Gln Leu Arg Lys Ala Leu Asn Thr Asn Leu Asp           
    295                 300                 305                           

ttc ttc ttc cag gga gtc gcc gct gga tgt acc cag gtc ttc cca tac       1104
Phe Phe Phe Gln Gly Val Ala Ala Gly Cys Thr Gln Val Phe Pro Tyr           
310                 315                 320                 325           

ggg cga gat tga                                                       1116
Gly Arg Asp                                                               
                                                                          


<210>  4
<211>  371
<212>  PRT
<213>  Agrocybe aegerita

<400>  4

Met Lys Tyr Phe Pro Leu Phe Pro Thr Leu Val Tyr Ala Val Gly Val 
            -40                 -35                 -30         


Val Ala Phe Pro Asp Tyr Ala Ser Leu Ala Gly Leu Ser Gln Gln Glu 
        -25                 -20                 -15             


Leu Asp Ala Ile Ile Pro Thr Leu Glu Ala Arg Glu Pro Gly Leu Pro 
    -10                 -5              -1  1               5   


Pro Gly Pro Leu Glu Asn Ser Ser Ala Lys Leu Val Asn Asp Glu Ala 
                10                  15                  20      


His Pro Trp Lys Pro Leu Arg Pro Gly Asp Ile Arg Gly Pro Cys Pro 
            25                  30                  35          


Gly Leu Asn Thr Leu Ala Ser His Gly Tyr Leu Pro Arg Asn Gly Val 
        40                  45                  50              


Ala Thr Pro Val Gln Ile Ile Asn Ala Val Gln Glu Gly Leu Asn Phe 
    55                  60                  65                  


Asp Asn Gln Ala Ala Val Phe Ala Thr Tyr Ala Ala His Leu Val Asp 
70                  75                  80                  85  


Gly Asn Leu Ile Thr Asp Leu Leu Ser Ile Gly Arg Lys Thr Arg Leu 
                90                  95                  100     


Thr Gly Pro Asp Pro Pro Pro Pro Ala Ser Val Gly Gly Leu Asn Glu 
            105                 110                 115         


His Gly Thr Phe Glu Gly Asp Ala Ser Met Thr Arg Gly Asp Ala Phe 
        120                 125                 130             


Phe Gly Asn Asn His Asp Phe Asn Glu Thr Leu Phe Glu Gln Leu Val 
    135                 140                 145                 


Asp Tyr Ser Asn Arg Phe Gly Gly Gly Lys Tyr Asn Leu Thr Val Ala 
150                 155                 160                 165 


Gly Glu Leu Arg Phe Lys Arg Ile Gln Asp Ser Ile Ala Thr Asn Pro 
                170                 175                 180     


Asn Phe Ser Phe Val Asp Phe Arg Phe Phe Thr Ala Tyr Gly Glu Thr 
            185                 190                 195         


Thr Phe Pro Ala Asn Leu Phe Val Asp Gly Arg Arg Asp Asp Gly Gln 
        200                 205                 210             


Leu Asp Met Asp Ala Ala Arg Ser Phe Phe Gln Phe Ser Arg Met Pro 
    215                 220                 225                 


Asp Asp Phe Phe Arg Ala Pro Ser Pro Arg Ser Gly Thr Gly Val Glu 
230                 235                 240                 245 


Val Val Ile Gln Ala His Pro Met Gln Pro Gly Arg Asn Val Gly Lys 
                250                 255                 260     


Ile Asn Ser Tyr Thr Val Asp Pro Thr Ser Ser Asp Phe Ser Thr Pro 
            265                 270                 275         


Cys Leu Met Tyr Glu Lys Phe Val Asn Ile Thr Val Lys Ser Leu Tyr 
        280                 285                 290             


Pro Asn Pro Thr Val Gln Leu Arg Lys Ala Leu Asn Thr Asn Leu Asp 
    295                 300                 305                 


Phe Phe Phe Gln Gly Val Ala Ala Gly Cys Thr Gln Val Phe Pro Tyr 
310                 315                 320                 325 


Gly Arg Asp 
            


<210>  5
<211>  1116
<212>  DNA
<213>  Agrocybe aegerita


<220>
<221>  CDS
<222>  (1)..(1113)

<220>
<221>  mat_peptide
<222>  (130)..(1116)

<400>  5
atg aaa tat ttt ccc ctg ttc cca acc ttg gtc tac gca gtg ggg gtc         48
Met Lys Tyr Phe Pro Leu Phe Pro Thr Leu Val Tyr Ala Val Gly Val           
            -40                 -35                 -30                   

gtt gct ttt cct gac tac gcc tca ttg gcc ggc ctc agc cag cag gaa         96
Val Ala Phe Pro Asp Tyr Ala Ser Leu Ala Gly Leu Ser Gln Gln Glu           
        -25                 -20                 -15                       

ttg gac gct ata atc cca aca ctc gag gcc cga gag cca gga tta cct        144
Leu Asp Ala Ile Ile Pro Thr Leu Glu Ala Arg Glu Pro Gly Leu Pro           
    -10                 -5              -1  1               5             

cct ggt cct ctc gag aat agc tct gca aag ttg gtg aac gac gag gct        192
Pro Gly Pro Leu Glu Asn Ser Ser Ala Lys Leu Val Asn Asp Glu Ala           
                10                  15                  20                

cac cca tgg aag ccg ctt cga cct ggc gat att cgt gga cct tgc cct        240
His Pro Trp Lys Pro Leu Arg Pro Gly Asp Ile Arg Gly Pro Cys Pro           
            25                  30                  35                    

ggt ctc aat act ctg gca tct cac ggg tac ctc ccg aga aat ggc gtt        288
Gly Leu Asn Thr Leu Ala Ser His Gly Tyr Leu Pro Arg Asn Gly Val           
        40                  45                  50                        

gca acc ccg gtg caa ata ata aac gcg gtt cag gaa gga ctc aat ttc        336
Ala Thr Pro Val Gln Ile Ile Asn Ala Val Gln Glu Gly Leu Asn Phe           
    55                  60                  65                            

gac aat caa gcc gca gtc ttc gcc aca tat gcg gcc cac ctt gtg gac        384
Asp Asn Gln Ala Ala Val Phe Ala Thr Tyr Ala Ala His Leu Val Asp           
70                  75                  80                  85            

ggc aat ctc att acg gac ttg ctg agc atc gga cgc aag acg cgg ctc        432
Gly Asn Leu Ile Thr Asp Leu Leu Ser Ile Gly Arg Lys Thr Arg Leu           
                90                  95                  100               

act ggg cct gat cca cca ccc ccc gct tcc gtt ggt gga ctc aat gag        480
Thr Gly Pro Asp Pro Pro Pro Pro Ala Ser Val Gly Gly Leu Asn Glu           
            105                 110                 115                   

cat ggc acc ttc gaa ggc gac gcc agt atg acc cga ggt gac gca ttc        528
His Gly Thr Phe Glu Gly Asp Ala Ser Met Thr Arg Gly Asp Ala Phe           
        120                 125                 130                       

ttt ggc aac aac cac gat ttc aat gag acg ctc ttc gaa cag ttg gtt        576
Phe Gly Asn Asn His Asp Phe Asn Glu Thr Leu Phe Glu Gln Leu Val           
    135                 140                 145                           

gac tac agc aac cga ttt gga gga gga aaa tac aat ctt acc gtc gcg        624
Asp Tyr Ser Asn Arg Phe Gly Gly Gly Lys Tyr Asn Leu Thr Val Ala           
150                 155                 160                 165           

ggg gag ctc cgt ttc aag cgc att caa gac tcc att gcg acc aac ccc        672
Gly Glu Leu Arg Phe Lys Arg Ile Gln Asp Ser Ile Ala Thr Asn Pro           
                170                 175                 180               

aat ttc tcc ttt gtt gac ttt agg ttc ttt act gct tac ggc gag acc        720
Asn Phe Ser Phe Val Asp Phe Arg Phe Phe Thr Ala Tyr Gly Glu Thr           
            185                 190                 195                   

acc ttc ccc gcg aat ctt ttt gtg gat ggg cgc agg gac gac ggc cag        768
Thr Phe Pro Ala Asn Leu Phe Val Asp Gly Arg Arg Asp Asp Gly Gln           
        200                 205                 210                       

cta gat atg gat gct gca cgg agt ttt ttc caa ttc agc cgt atg cct        816
Leu Asp Met Asp Ala Ala Arg Ser Phe Phe Gln Phe Ser Arg Met Pro           
    215                 220                 225                           

gac gat ttc ttc cgc gca ccc agc ccg aga agt ggc aca gga gtc gag        864
Asp Asp Phe Phe Arg Ala Pro Ser Pro Arg Ser Gly Thr Gly Val Glu           
230                 235                 240                 245           

gta gtt ata cag gct cat cct atg cag ccc gga aga aat gtc ggc aag        912
Val Val Ile Gln Ala His Pro Met Gln Pro Gly Arg Asn Val Gly Lys           
                250                 255                 260               

atc aac agc tac acc gtc gac cca aca tcc tct gac ttt tcc acc ccc        960
Ile Asn Ser Tyr Thr Val Asp Pro Thr Ser Ser Asp Phe Ser Thr Pro           
            265                 270                 275                   

tgc ttg atg tac gag aaa ttc gtc aac ata acg gtc aag tca ctc tac       1008
Cys Leu Met Tyr Glu Lys Phe Val Asn Ile Thr Val Lys Ser Leu Tyr           
        280                 285                 290                       

ccg aat ccg acg gtg cag ctt cgc aaa gcc ctt aat acg aat ctc gat       1056
Pro Asn Pro Thr Val Gln Leu Arg Lys Ala Leu Asn Thr Asn Leu Asp           
    295                 300                 305                           

ttc ttc ttc cag gga gtc gcc gct gga tgt acc cag gtc ttc cca tac       1104
Phe Phe Phe Gln Gly Val Ala Ala Gly Cys Thr Gln Val Phe Pro Tyr           
310                 315                 320                 325           

ggg cga gat tga                                                       1116
Gly Arg Asp                                                               
                                                                          


<210>  6
<211>  371
<212>  PRT
<213>  Agrocybe aegerita

<400>  6

Met Lys Tyr Phe Pro Leu Phe Pro Thr Leu Val Tyr Ala Val Gly Val 
            -40                 -35                 -30         


Val Ala Phe Pro Asp Tyr Ala Ser Leu Ala Gly Leu Ser Gln Gln Glu 
        -25                 -20                 -15             


Leu Asp Ala Ile Ile Pro Thr Leu Glu Ala Arg Glu Pro Gly Leu Pro 
    -10                 -5              -1  1               5   


Pro Gly Pro Leu Glu Asn Ser Ser Ala Lys Leu Val Asn Asp Glu Ala 
                10                  15                  20      


His Pro Trp Lys Pro Leu Arg Pro Gly Asp Ile Arg Gly Pro Cys Pro 
            25                  30                  35          


Gly Leu Asn Thr Leu Ala Ser His Gly Tyr Leu Pro Arg Asn Gly Val 
        40                  45                  50              


Ala Thr Pro Val Gln Ile Ile Asn Ala Val Gln Glu Gly Leu Asn Phe 
    55                  60                  65                  


Asp Asn Gln Ala Ala Val Phe Ala Thr Tyr Ala Ala His Leu Val Asp 
70                  75                  80                  85  


Gly Asn Leu Ile Thr Asp Leu Leu Ser Ile Gly Arg Lys Thr Arg Leu 
                90                  95                  100     


Thr Gly Pro Asp Pro Pro Pro Pro Ala Ser Val Gly Gly Leu Asn Glu 
            105                 110                 115         


His Gly Thr Phe Glu Gly Asp Ala Ser Met Thr Arg Gly Asp Ala Phe 
        120                 125                 130             


Phe Gly Asn Asn His Asp Phe Asn Glu Thr Leu Phe Glu Gln Leu Val 
    135                 140                 145                 


Asp Tyr Ser Asn Arg Phe Gly Gly Gly Lys Tyr Asn Leu Thr Val Ala 
150                 155                 160                 165 


Gly Glu Leu Arg Phe Lys Arg Ile Gln Asp Ser Ile Ala Thr Asn Pro 
                170                 175                 180     


Asn Phe Ser Phe Val Asp Phe Arg Phe Phe Thr Ala Tyr Gly Glu Thr 
            185                 190                 195         


Thr Phe Pro Ala Asn Leu Phe Val Asp Gly Arg Arg Asp Asp Gly Gln 
        200                 205                 210             


Leu Asp Met Asp Ala Ala Arg Ser Phe Phe Gln Phe Ser Arg Met Pro 
    215                 220                 225                 


Asp Asp Phe Phe Arg Ala Pro Ser Pro Arg Ser Gly Thr Gly Val Glu 
230                 235                 240                 245 


Val Val Ile Gln Ala His Pro Met Gln Pro Gly Arg Asn Val Gly Lys 
                250                 255                 260     


Ile Asn Ser Tyr Thr Val Asp Pro Thr Ser Ser Asp Phe Ser Thr Pro 
            265                 270                 275         


Cys Leu Met Tyr Glu Lys Phe Val Asn Ile Thr Val Lys Ser Leu Tyr 
        280                 285                 290             


Pro Asn Pro Thr Val Gln Leu Arg Lys Ala Leu Asn Thr Asn Leu Asp 
    295                 300                 305                 


Phe Phe Phe Gln Gly Val Ala Ala Gly Cys Thr Gln Val Phe Pro Tyr 
310                 315                 320                 325 


Gly Arg Asp 
            


<210>  7
<211>  987
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variante wt-JaWa


<220>
<221>  CDS
<222>  (1)..(987)

<400>  7
gag cca gga tta cct cct ggt cct ctc gag aat agc tct gca aag ttg         48
Glu Pro Gly Leu Pro Pro Gly Pro Leu Glu Asn Ser Ser Ala Lys Leu           
1               5                   10                  15                

gtg aac gac gag gct cac cca tgg aag ccg ctt cga cct ggc gat att         96
Val Asn Asp Glu Ala His Pro Trp Lys Pro Leu Arg Pro Gly Asp Ile           
            20                  25                  30                    

cgt gga cct tgc cct ggt ctc aat act ctg gca tct cac ggg tac ctc        144
Arg Gly Pro Cys Pro Gly Leu Asn Thr Leu Ala Ser His Gly Tyr Leu           
        35                  40                  45                        

ccg aga aat ggc gtt gca acc ccg gtg caa ata ata aac gcg gtt cag        192
Pro Arg Asn Gly Val Ala Thr Pro Val Gln Ile Ile Asn Ala Val Gln           
    50                  55                  60                            

gaa gga ctc aat ttc gac aat caa gcc gca gtc ttc gcc aca tat gcg        240
Glu Gly Leu Asn Phe Asp Asn Gln Ala Ala Val Phe Ala Thr Tyr Ala           
65                  70                  75                  80            

gcc cac ctt gtg gac ggc aat ctc att acg gac ttg ctg agc atc gga        288
Ala His Leu Val Asp Gly Asn Leu Ile Thr Asp Leu Leu Ser Ile Gly           
                85                  90                  95                

cgc aag acg cgg ctc act ggg cct gat cca cca ccc ccc gct tcc gtt        336
Arg Lys Thr Arg Leu Thr Gly Pro Asp Pro Pro Pro Pro Ala Ser Val           
            100                 105                 110                   

ggt gga ctc aat gag cat ggc acc ttc gaa ggc gac gcc agt atg acc        384
Gly Gly Leu Asn Glu His Gly Thr Phe Glu Gly Asp Ala Ser Met Thr           
        115                 120                 125                       

cga ggt gac gca ttc ttt ggc aac aac cac gat ttc aat gag acg ctc        432
Arg Gly Asp Ala Phe Phe Gly Asn Asn His Asp Phe Asn Glu Thr Leu           
    130                 135                 140                           

ttc gaa cag ttg gtt gac tac agc aac cga ttt gga gga gga aaa tac        480
Phe Glu Gln Leu Val Asp Tyr Ser Asn Arg Phe Gly Gly Gly Lys Tyr           
145                 150                 155                 160           

aat ctt acc gtc gcg ggg gag ctc cgt ttc aag cgc att caa gac tcc        528
Asn Leu Thr Val Ala Gly Glu Leu Arg Phe Lys Arg Ile Gln Asp Ser           
                165                 170                 175               

att gcg acc aac ccc aat ttc tcc ttt gtt gac ttt agg ttc ttt act        576
Ile Ala Thr Asn Pro Asn Phe Ser Phe Val Asp Phe Arg Phe Phe Thr           
            180                 185                 190                   

gct tac ggc gag acc acc ttc ccc gcg aat ctt ttt gtg gat ggg cgc        624
Ala Tyr Gly Glu Thr Thr Phe Pro Ala Asn Leu Phe Val Asp Gly Arg           
        195                 200                 205                       

agg gac gac ggc cag cta gat atg gat gct gca cgg agt ttt ttc caa        672
Arg Asp Asp Gly Gln Leu Asp Met Asp Ala Ala Arg Ser Phe Phe Gln           
    210                 215                 220                           

ttc agc cgt atg cct gac gat ttc ttc cgc gca ccc agc ccg aga agt        720
Phe Ser Arg Met Pro Asp Asp Phe Phe Arg Ala Pro Ser Pro Arg Ser           
225                 230                 235                 240           

gac aca gga gtc gag gta gtt ata cag gct cat cct atg cag ccc gga        768
Asp Thr Gly Val Glu Val Val Ile Gln Ala His Pro Met Gln Pro Gly           
                245                 250                 255               

aaa aat gtc ggc aag atc aac agc tac acc gtc gac cca aca tcc tct        816
Lys Asn Val Gly Lys Ile Asn Ser Tyr Thr Val Asp Pro Thr Ser Ser           
            260                 265                 270                   

gac ttt tcc acc ccc tgc ttg atg tac gag aaa ttc gtc aac ata acg        864
Asp Phe Ser Thr Pro Cys Leu Met Tyr Glu Lys Phe Val Asn Ile Thr           
        275                 280                 285                       

gtc aag tca ctc tac ccg aat ccg acg gtg cag ctt cgc aaa gcc ctt        912
Val Lys Ser Leu Tyr Pro Asn Pro Thr Val Gln Leu Arg Lys Ala Leu           
    290                 295                 300                           

aat acg aat ctc gat ttc ttc ttc cag gga gtc gcc gct gga tgt acc        960
Asn Thr Asn Leu Asp Phe Phe Phe Gln Gly Val Ala Ala Gly Cys Thr           
305                 310                 315                 320           

cag gtc ttc cca tac ggg cga gat tga                                    987
Gln Val Phe Pro Tyr Gly Arg Asp                                           
                325                                                       


<210>  8
<211>  328
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  8

Glu Pro Gly Leu Pro Pro Gly Pro Leu Glu Asn Ser Ser Ala Lys Leu 
1               5                   10                  15      


Val Asn Asp Glu Ala His Pro Trp Lys Pro Leu Arg Pro Gly Asp Ile 
            20                  25                  30          


Arg Gly Pro Cys Pro Gly Leu Asn Thr Leu Ala Ser His Gly Tyr Leu 
        35                  40                  45              


Pro Arg Asn Gly Val Ala Thr Pro Val Gln Ile Ile Asn Ala Val Gln 
    50                  55                  60                  


Glu Gly Leu Asn Phe Asp Asn Gln Ala Ala Val Phe Ala Thr Tyr Ala 
65                  70                  75                  80  


Ala His Leu Val Asp Gly Asn Leu Ile Thr Asp Leu Leu Ser Ile Gly 
                85                  90                  95      


Arg Lys Thr Arg Leu Thr Gly Pro Asp Pro Pro Pro Pro Ala Ser Val 
            100                 105                 110         


Gly Gly Leu Asn Glu His Gly Thr Phe Glu Gly Asp Ala Ser Met Thr 
        115                 120                 125             


Arg Gly Asp Ala Phe Phe Gly Asn Asn His Asp Phe Asn Glu Thr Leu 
    130                 135                 140                 


Phe Glu Gln Leu Val Asp Tyr Ser Asn Arg Phe Gly Gly Gly Lys Tyr 
145                 150                 155                 160 


Asn Leu Thr Val Ala Gly Glu Leu Arg Phe Lys Arg Ile Gln Asp Ser 
                165                 170                 175     


Ile Ala Thr Asn Pro Asn Phe Ser Phe Val Asp Phe Arg Phe Phe Thr 
            180                 185                 190         


Ala Tyr Gly Glu Thr Thr Phe Pro Ala Asn Leu Phe Val Asp Gly Arg 
        195                 200                 205             


Arg Asp Asp Gly Gln Leu Asp Met Asp Ala Ala Arg Ser Phe Phe Gln 
    210                 215                 220                 


Phe Ser Arg Met Pro Asp Asp Phe Phe Arg Ala Pro Ser Pro Arg Ser 
225                 230                 235                 240 


Asp Thr Gly Val Glu Val Val Ile Gln Ala His Pro Met Gln Pro Gly 
                245                 250                 255     


Lys Asn Val Gly Lys Ile Asn Ser Tyr Thr Val Asp Pro Thr Ser Ser 
            260                 265                 270         


Asp Phe Ser Thr Pro Cys Leu Met Tyr Glu Lys Phe Val Asn Ile Thr 
        275                 280                 285             


Val Lys Ser Leu Tyr Pro Asn Pro Thr Val Gln Leu Arg Lys Ala Leu 
    290                 295                 300                 


Asn Thr Asn Leu Asp Phe Phe Phe Gln Gly Val Ala Ala Gly Cys Thr 
305                 310                 315                 320 


Gln Val Phe Pro Tyr Gly Arg Asp 
                325             


<210>  9
<211>  1116
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variante wt-JaWa con peptido seal silvestre


<220>
<221>  CDS
<222>  (1)..(1113)

<220>
<221>  mat_peptide
<222>  (130)..(1116)

<400>  9
atg aaa tat ttt ccc ctg ttc cca acc ttg gtc ttc gca gcg agg gtc         48
Met Lys Tyr Phe Pro Leu Phe Pro Thr Leu Val Phe Ala Ala Arg Val           
            -40                 -35                 -30                   

gtt gct ttt cct gcc tac gcc tca ttg gcc ggc ctc agc cag cag gaa         96
Val Ala Phe Pro Ala Tyr Ala Ser Leu Ala Gly Leu Ser Gln Gln Glu           
        -25                 -20                 -15                       

ttg gac gct ata atc cca aca ctc gag gcc cga gag cca gga tta cct        144
Leu Asp Ala Ile Ile Pro Thr Leu Glu Ala Arg Glu Pro Gly Leu Pro           
    -10                 -5              -1  1               5             

cct ggt cct ctc gag aat agc tct gca aag ttg gtg aac gac gag gct        192
Pro Gly Pro Leu Glu Asn Ser Ser Ala Lys Leu Val Asn Asp Glu Ala           
                10                  15                  20                

cac cca tgg aag ccg ctt cga cct ggc gat att cgt gga cct tgc cct        240
His Pro Trp Lys Pro Leu Arg Pro Gly Asp Ile Arg Gly Pro Cys Pro           
            25                  30                  35                    

ggt ctc aat act ctg gca tct cac ggg tac ctc ccg aga aat ggc gtt        288
Gly Leu Asn Thr Leu Ala Ser His Gly Tyr Leu Pro Arg Asn Gly Val           
        40                  45                  50                        

gca acc ccg gtg caa ata ata aac gcg gtt cag gaa gga ctc aat ttc        336
Ala Thr Pro Val Gln Ile Ile Asn Ala Val Gln Glu Gly Leu Asn Phe           
    55                  60                  65                            

gac aat caa gcc gca gtc ttc gcc aca tat gcg gcc cac ctt gtg gac        384
Asp Asn Gln Ala Ala Val Phe Ala Thr Tyr Ala Ala His Leu Val Asp           
70                  75                  80                  85            

ggc aat ctc att acg gac ttg ctg agc atc gga cgc aag acg cgg ctc        432
Gly Asn Leu Ile Thr Asp Leu Leu Ser Ile Gly Arg Lys Thr Arg Leu           
                90                  95                  100               

act ggg cct gat cca cca ccc ccc gct tcc gtt ggt gga ctc aat gag        480
Thr Gly Pro Asp Pro Pro Pro Pro Ala Ser Val Gly Gly Leu Asn Glu           
            105                 110                 115                   

cat ggc acc ttc gaa ggc gac gcc agt atg acc cga ggt gac gca ttc        528
His Gly Thr Phe Glu Gly Asp Ala Ser Met Thr Arg Gly Asp Ala Phe           
        120                 125                 130                       

ttt ggc aac aac cac gat ttc aat gag acg ctc ttc gaa cag ttg gtt        576
Phe Gly Asn Asn His Asp Phe Asn Glu Thr Leu Phe Glu Gln Leu Val           
    135                 140                 145                           

gac tac agc aac cga ttt gga gga gga aaa tac aat ctt acc gtc gcg        624
Asp Tyr Ser Asn Arg Phe Gly Gly Gly Lys Tyr Asn Leu Thr Val Ala           
150                 155                 160                 165           

ggg gag ctc cgt ttc aag cgc att caa gac tcc att gcg acc aac ccc        672
Gly Glu Leu Arg Phe Lys Arg Ile Gln Asp Ser Ile Ala Thr Asn Pro           
                170                 175                 180               

aat ttc tcc ttt gtt gac ttt agg ttc ttt act gct tac ggc gag acc        720
Asn Phe Ser Phe Val Asp Phe Arg Phe Phe Thr Ala Tyr Gly Glu Thr           
            185                 190                 195                   

acc ttc ccc gcg aat ctt ttt gtg gat ggg cgc agg gac gac ggc cag        768
Thr Phe Pro Ala Asn Leu Phe Val Asp Gly Arg Arg Asp Asp Gly Gln           
        200                 205                 210                       

cta gat atg gat gct gca cgg agt ttt ttc caa ttc agc cgt atg cct        816
Leu Asp Met Asp Ala Ala Arg Ser Phe Phe Gln Phe Ser Arg Met Pro           
    215                 220                 225                           

gac gat ttc ttc cgc gca ccc agc ccg aga agt gac aca gga gtc gag        864
Asp Asp Phe Phe Arg Ala Pro Ser Pro Arg Ser Asp Thr Gly Val Glu           
230                 235                 240                 245           

gta gtt ata cag gct cat cct atg cag ccc gga aaa aat gtc ggc aag        912
Val Val Ile Gln Ala His Pro Met Gln Pro Gly Lys Asn Val Gly Lys           
                250                 255                 260               

atc aac agc tac acc gtc gac cca aca tcc tct gac ttt tcc acc ccc        960
Ile Asn Ser Tyr Thr Val Asp Pro Thr Ser Ser Asp Phe Ser Thr Pro           
            265                 270                 275                   

tgc ttg atg tac gag aaa ttc gtc aac ata acg gtc aag tca ctc tac       1008
Cys Leu Met Tyr Glu Lys Phe Val Asn Ile Thr Val Lys Ser Leu Tyr           
        280                 285                 290                       

ccg aat ccg acg gtg cag ctt cgc aaa gcc ctt aat acg aat ctc gat       1056
Pro Asn Pro Thr Val Gln Leu Arg Lys Ala Leu Asn Thr Asn Leu Asp           
    295                 300                 305                           

ttc ttc ttc cag gga gtc gcc gct gga tgt acc cag gtc ttc cca tac       1104
Phe Phe Phe Gln Gly Val Ala Ala Gly Cys Thr Gln Val Phe Pro Tyr           
310                 315                 320                 325           

ggg cga gat tga                                                       1116
Gly Arg Asp                                                               
                                                                          


<210>  10
<211>  371
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  10

Met Lys Tyr Phe Pro Leu Phe Pro Thr Leu Val Phe Ala Ala Arg Val 
            -40                 -35                 -30         


Val Ala Phe Pro Ala Tyr Ala Ser Leu Ala Gly Leu Ser Gln Gln Glu 
        -25                 -20                 -15             


Leu Asp Ala Ile Ile Pro Thr Leu Glu Ala Arg Glu Pro Gly Leu Pro 
    -10                 -5              -1  1               5   


Pro Gly Pro Leu Glu Asn Ser Ser Ala Lys Leu Val Asn Asp Glu Ala 
                10                  15                  20      


His Pro Trp Lys Pro Leu Arg Pro Gly Asp Ile Arg Gly Pro Cys Pro 
            25                  30                  35          


Gly Leu Asn Thr Leu Ala Ser His Gly Tyr Leu Pro Arg Asn Gly Val 
        40                  45                  50              


Ala Thr Pro Val Gln Ile Ile Asn Ala Val Gln Glu Gly Leu Asn Phe 
    55                  60                  65                  


Asp Asn Gln Ala Ala Val Phe Ala Thr Tyr Ala Ala His Leu Val Asp 
70                  75                  80                  85  


Gly Asn Leu Ile Thr Asp Leu Leu Ser Ile Gly Arg Lys Thr Arg Leu 
                90                  95                  100     


Thr Gly Pro Asp Pro Pro Pro Pro Ala Ser Val Gly Gly Leu Asn Glu 
            105                 110                 115         


His Gly Thr Phe Glu Gly Asp Ala Ser Met Thr Arg Gly Asp Ala Phe 
        120                 125                 130             


Phe Gly Asn Asn His Asp Phe Asn Glu Thr Leu Phe Glu Gln Leu Val 
    135                 140                 145                 


Asp Tyr Ser Asn Arg Phe Gly Gly Gly Lys Tyr Asn Leu Thr Val Ala 
150                 155                 160                 165 


Gly Glu Leu Arg Phe Lys Arg Ile Gln Asp Ser Ile Ala Thr Asn Pro 
                170                 175                 180     


Asn Phe Ser Phe Val Asp Phe Arg Phe Phe Thr Ala Tyr Gly Glu Thr 
            185                 190                 195         


Thr Phe Pro Ala Asn Leu Phe Val Asp Gly Arg Arg Asp Asp Gly Gln 
        200                 205                 210             


Leu Asp Met Asp Ala Ala Arg Ser Phe Phe Gln Phe Ser Arg Met Pro 
    215                 220                 225                 


Asp Asp Phe Phe Arg Ala Pro Ser Pro Arg Ser Asp Thr Gly Val Glu 
230                 235                 240                 245 


Val Val Ile Gln Ala His Pro Met Gln Pro Gly Lys Asn Val Gly Lys 
                250                 255                 260     


Ile Asn Ser Tyr Thr Val Asp Pro Thr Ser Ser Asp Phe Ser Thr Pro 
            265                 270                 275         


Cys Leu Met Tyr Glu Lys Phe Val Asn Ile Thr Val Lys Ser Leu Tyr 
        280                 285                 290             


Pro Asn Pro Thr Val Gln Leu Arg Lys Ala Leu Asn Thr Asn Leu Asp 
    295                 300                 305                 


Phe Phe Phe Gln Gly Val Ala Ala Gly Cys Thr Gln Val Phe Pro Tyr 
310                 315                 320                 325 


Gly Arg Asp 
            


<210>  11
<211>  1116
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variante wt-JaWa con pptido seal modificado


<220>
<221>  CDS
<222>  (1)..(1113)

<220>
<221>  mat_peptide
<222>  (130)..(1116)

<400>  11
atg aaa tat ttt ccc ctg ttc cca acc ttg gtc tac gca gtg ggg gtc         48
Met Lys Tyr Phe Pro Leu Phe Pro Thr Leu Val Tyr Ala Val Gly Val           
            -40                 -35                 -30                   

gtt gct ttt cct gac tac gcc tca ttg gcc ggc ctc agc cag cag gaa         96
Val Ala Phe Pro Asp Tyr Ala Ser Leu Ala Gly Leu Ser Gln Gln Glu           
        -25                 -20                 -15                       

ttg gac gct ata atc cca aca ctc gag gcc cga gag cca gga tta cct        144
Leu Asp Ala Ile Ile Pro Thr Leu Glu Ala Arg Glu Pro Gly Leu Pro           
    -10                 -5              -1  1               5             

cct ggt cct ctc gag aat agc tct gca aag ttg gtg aac gac gag gct        192
Pro Gly Pro Leu Glu Asn Ser Ser Ala Lys Leu Val Asn Asp Glu Ala           
                10                  15                  20                

cac cca tgg aag ccg ctt cga cct ggc gat att cgt gga cct tgc cct        240
His Pro Trp Lys Pro Leu Arg Pro Gly Asp Ile Arg Gly Pro Cys Pro           
            25                  30                  35                    

ggt ctc aat act ctg gca tct cac ggg tac ctc ccg aga aat ggc gtt        288
Gly Leu Asn Thr Leu Ala Ser His Gly Tyr Leu Pro Arg Asn Gly Val           
        40                  45                  50                        

gca acc ccg gtg caa ata ata aac gcg gtt cag gaa gga ctc aat ttc        336
Ala Thr Pro Val Gln Ile Ile Asn Ala Val Gln Glu Gly Leu Asn Phe           
    55                  60                  65                            

gac aat caa gcc gca gtc ttc gcc aca tat gcg gcc cac ctt gtg gac        384
Asp Asn Gln Ala Ala Val Phe Ala Thr Tyr Ala Ala His Leu Val Asp           
70                  75                  80                  85            

ggc aat ctc att acg gac ttg ctg agc atc gga cgc aag acg cgg ctc        432
Gly Asn Leu Ile Thr Asp Leu Leu Ser Ile Gly Arg Lys Thr Arg Leu           
                90                  95                  100               

act ggg cct gat cca cca ccc ccc gct tcc gtt ggt gga ctc aat gag        480
Thr Gly Pro Asp Pro Pro Pro Pro Ala Ser Val Gly Gly Leu Asn Glu           
            105                 110                 115                   

cat ggc acc ttc gaa ggc gac gcc agt atg acc cga ggt gac gca ttc        528
His Gly Thr Phe Glu Gly Asp Ala Ser Met Thr Arg Gly Asp Ala Phe           
        120                 125                 130                       

ttt ggc aac aac cac gat ttc aat gag acg ctc ttc gaa cag ttg gtt        576
Phe Gly Asn Asn His Asp Phe Asn Glu Thr Leu Phe Glu Gln Leu Val           
    135                 140                 145                           

gac tac agc aac cga ttt gga gga gga aaa tac aat ctt acc gtc gcg        624
Asp Tyr Ser Asn Arg Phe Gly Gly Gly Lys Tyr Asn Leu Thr Val Ala           
150                 155                 160                 165           

ggg gag ctc cgt ttc aag cgc att caa gac tcc att gcg acc aac ccc        672
Gly Glu Leu Arg Phe Lys Arg Ile Gln Asp Ser Ile Ala Thr Asn Pro           
                170                 175                 180               

aat ttc tcc ttt gtt gac ttt agg ttc ttt act gct tac ggc gag acc        720
Asn Phe Ser Phe Val Asp Phe Arg Phe Phe Thr Ala Tyr Gly Glu Thr           
            185                 190                 195                   

acc ttc ccc gcg aat ctt ttt gtg gat ggg cgc agg gac gac ggc cag        768
Thr Phe Pro Ala Asn Leu Phe Val Asp Gly Arg Arg Asp Asp Gly Gln           
        200                 205                 210                       

cta gat atg gat gct gca cgg agt ttt ttc caa ttc agc cgt atg cct        816
Leu Asp Met Asp Ala Ala Arg Ser Phe Phe Gln Phe Ser Arg Met Pro           
    215                 220                 225                           

gac gat ttc ttc cgc gca ccc agc ccg aga agt gac aca gga gtc gag        864
Asp Asp Phe Phe Arg Ala Pro Ser Pro Arg Ser Asp Thr Gly Val Glu           
230                 235                 240                 245           

gta gtt ata cag gct cat cct atg cag ccc gga aaa aat gtc ggc aag        912
Val Val Ile Gln Ala His Pro Met Gln Pro Gly Lys Asn Val Gly Lys           
                250                 255                 260               

atc aac agc tac acc gtc gac cca aca tcc tct gac ttt tcc acc ccc        960
Ile Asn Ser Tyr Thr Val Asp Pro Thr Ser Ser Asp Phe Ser Thr Pro           
            265                 270                 275                   

tgc ttg atg tac gag aaa ttc gtc aac ata acg gtc aag tca ctc tac       1008
Cys Leu Met Tyr Glu Lys Phe Val Asn Ile Thr Val Lys Ser Leu Tyr           
        280                 285                 290                       

ccg aat ccg acg gtg cag ctt cgc aaa gcc ctt aat acg aat ctc gat       1056
Pro Asn Pro Thr Val Gln Leu Arg Lys Ala Leu Asn Thr Asn Leu Asp           
    295                 300                 305                           

ttc ttc ttc cag gga gtc gcc gct gga tgt acc cag gtc ttc cca tac       1104
Phe Phe Phe Gln Gly Val Ala Ala Gly Cys Thr Gln Val Phe Pro Tyr           
310                 315                 320                 325           

ggg cga gat tga                                                       1116
Gly Arg Asp                                                               
                                                                          


<210>  12
<211>  371
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  12

Met Lys Tyr Phe Pro Leu Phe Pro Thr Leu Val Tyr Ala Val Gly Val 
            -40                 -35                 -30         


Val Ala Phe Pro Asp Tyr Ala Ser Leu Ala Gly Leu Ser Gln Gln Glu 
        -25                 -20                 -15             


Leu Asp Ala Ile Ile Pro Thr Leu Glu Ala Arg Glu Pro Gly Leu Pro 
    -10                 -5              -1  1               5   


Pro Gly Pro Leu Glu Asn Ser Ser Ala Lys Leu Val Asn Asp Glu Ala 
                10                  15                  20      


His Pro Trp Lys Pro Leu Arg Pro Gly Asp Ile Arg Gly Pro Cys Pro 
            25                  30                  35          


Gly Leu Asn Thr Leu Ala Ser His Gly Tyr Leu Pro Arg Asn Gly Val 
        40                  45                  50              


Ala Thr Pro Val Gln Ile Ile Asn Ala Val Gln Glu Gly Leu Asn Phe 
    55                  60                  65                  


Asp Asn Gln Ala Ala Val Phe Ala Thr Tyr Ala Ala His Leu Val Asp 
70                  75                  80                  85  


Gly Asn Leu Ile Thr Asp Leu Leu Ser Ile Gly Arg Lys Thr Arg Leu 
                90                  95                  100     


Thr Gly Pro Asp Pro Pro Pro Pro Ala Ser Val Gly Gly Leu Asn Glu 
            105                 110                 115         


His Gly Thr Phe Glu Gly Asp Ala Ser Met Thr Arg Gly Asp Ala Phe 
        120                 125                 130             


Phe Gly Asn Asn His Asp Phe Asn Glu Thr Leu Phe Glu Gln Leu Val 
    135                 140                 145                 


Asp Tyr Ser Asn Arg Phe Gly Gly Gly Lys Tyr Asn Leu Thr Val Ala 
150                 155                 160                 165 


Gly Glu Leu Arg Phe Lys Arg Ile Gln Asp Ser Ile Ala Thr Asn Pro 
                170                 175                 180     


Asn Phe Ser Phe Val Asp Phe Arg Phe Phe Thr Ala Tyr Gly Glu Thr 
            185                 190                 195         


Thr Phe Pro Ala Asn Leu Phe Val Asp Gly Arg Arg Asp Asp Gly Gln 
        200                 205                 210             


Leu Asp Met Asp Ala Ala Arg Ser Phe Phe Gln Phe Ser Arg Met Pro 
    215                 220                 225                 


Asp Asp Phe Phe Arg Ala Pro Ser Pro Arg Ser Asp Thr Gly Val Glu 
230                 235                 240                 245 


Val Val Ile Gln Ala His Pro Met Gln Pro Gly Lys Asn Val Gly Lys 
                250                 255                 260     


Ile Asn Ser Tyr Thr Val Asp Pro Thr Ser Ser Asp Phe Ser Thr Pro 
            265                 270                 275         


Cys Leu Met Tyr Glu Lys Phe Val Asn Ile Thr Val Lys Ser Leu Tyr 
        280                 285                 290             


Pro Asn Pro Thr Val Gln Leu Arg Lys Ala Leu Asn Thr Asn Leu Asp 
    295                 300                 305                 


Phe Phe Phe Gln Gly Val Ala Ala Gly Cys Thr Gln Val Phe Pro Tyr 
310                 315                 320                 325 


Gly Arg Asp 
            


<210>  13
<211>  984
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variante PaDa-I sin pptido seal


<220>
<221>  CDS
<222>  (1)..(984)

<400>  13
gag cca gga tta cct cct ggt cct ctc gag aat agc tct gca aag ttg         48
Glu Pro Gly Leu Pro Pro Gly Pro Leu Glu Asn Ser Ser Ala Lys Leu           
1               5                   10                  15                

gtg aac gac gag gct cac cca tgg aag ccg ctt cga cct ggc gat att         96
Val Asn Asp Glu Ala His Pro Trp Lys Pro Leu Arg Pro Gly Asp Ile           
            20                  25                  30                    

cgt gga cct tgc cct ggt ctc aat act ctg gca tct cac ggg tac ctc        144
Arg Gly Pro Cys Pro Gly Leu Asn Thr Leu Ala Ser His Gly Tyr Leu           
        35                  40                  45                        

ccg aga aat ggc gtt gca acc ccg gcg caa ata ata aac gcg gtt cag        192
Pro Arg Asn Gly Val Ala Thr Pro Ala Gln Ile Ile Asn Ala Val Gln           
    50                  55                  60                            

gaa gga ttc aat ttc gac aat caa gcc gca atc ttc gcc aca tat gcg        240
Glu Gly Phe Asn Phe Asp Asn Gln Ala Ala Ile Phe Ala Thr Tyr Ala           
65                  70                  75                  80            

gcc cac ctt gtg gac ggc aat ctc att acg gac ttg ctg agc atc gga        288
Ala His Leu Val Asp Gly Asn Leu Ile Thr Asp Leu Leu Ser Ile Gly           
                85                  90                  95                

cgc aag acg cgg ctc act ggg cct gat cca cca ccc ccc gct tcc gtt        336
Arg Lys Thr Arg Leu Thr Gly Pro Asp Pro Pro Pro Pro Ala Ser Val           
            100                 105                 110                   

ggt gga ctc aat gag cat ggc acc ttc gaa ggc gac gcc agt atg acc        384
Gly Gly Leu Asn Glu His Gly Thr Phe Glu Gly Asp Ala Ser Met Thr           
        115                 120                 125                       

cga ggt gac gca ttc ttt ggc aac aac cac gat ttc aat gag acg ctc        432
Arg Gly Asp Ala Phe Phe Gly Asn Asn His Asp Phe Asn Glu Thr Leu           
    130                 135                 140                           

ttc gaa cag ttg gtt gac tac agc aac cga ttt gga gga gga aaa tac        480
Phe Glu Gln Leu Val Asp Tyr Ser Asn Arg Phe Gly Gly Gly Lys Tyr           
145                 150                 155                 160           

aat ctt acc gtc gcg ggg gag ctc cgt ttc aag cgc att caa gac tcc        528
Asn Leu Thr Val Ala Gly Glu Leu Arg Phe Lys Arg Ile Gln Asp Ser           
                165                 170                 175               

att gcg acc aac ccc aat ttc tcc ttt gtt gac ttt agg ttc ttt act        576
Ile Ala Thr Asn Pro Asn Phe Ser Phe Val Asp Phe Arg Phe Phe Thr           
            180                 185                 190                   

gct tac ggc gag acc acc ttc ccc gcg aat ctt ttt gtg gat ggg cgc        624
Ala Tyr Gly Glu Thr Thr Phe Pro Ala Asn Leu Phe Val Asp Gly Arg           
        195                 200                 205                       

agg gac gac ggc cag cta gat atg gat gct gca cgg agt ttt ttc caa        672
Arg Asp Asp Gly Gln Leu Asp Met Asp Ala Ala Arg Ser Phe Phe Gln           
    210                 215                 220                           

ttc agc cgt atg cct gac gat ttc ttc cgc gca ccc agc ccg aga agt        720
Phe Ser Arg Met Pro Asp Asp Phe Phe Arg Ala Pro Ser Pro Arg Ser           
225                 230                 235                 240           

ggc aca gga gtc gag gta gtt gta cag gct cat cct atg cag ccc gga        768
Gly Thr Gly Val Glu Val Val Val Gln Ala His Pro Met Gln Pro Gly           
                245                 250                 255               

aga aat gtc ggc aag atc aac agc tac acc gtc gac cca aca tcc tct        816
Arg Asn Val Gly Lys Ile Asn Ser Tyr Thr Val Asp Pro Thr Ser Ser           
            260                 265                 270                   

gac ttt tcc acc ccc tgc ttg atg tac gag aaa ttc gtc aac ata acg        864
Asp Phe Ser Thr Pro Cys Leu Met Tyr Glu Lys Phe Val Asn Ile Thr           
        275                 280                 285                       

gtc aag tca ctc tac ccg aat ccg acg gtg cag ctt cgc aaa gcc ctt        912
Val Lys Ser Leu Tyr Pro Asn Pro Thr Val Gln Leu Arg Lys Ala Leu           
    290                 295                 300                           

aat acg aat ctc gat ttc tta ttc cag gga gtc gcc gct gga tgt acc        960
Asn Thr Asn Leu Asp Phe Leu Phe Gln Gly Val Ala Ala Gly Cys Thr           
305                 310                 315                 320           

cag gtc ttc cca tac ggg cga gat                                        984
Gln Val Phe Pro Tyr Gly Arg Asp                                           
                325                                                       


<210>  14
<211>  328
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  14

Glu Pro Gly Leu Pro Pro Gly Pro Leu Glu Asn Ser Ser Ala Lys Leu 
1               5                   10                  15      


Val Asn Asp Glu Ala His Pro Trp Lys Pro Leu Arg Pro Gly Asp Ile 
            20                  25                  30          


Arg Gly Pro Cys Pro Gly Leu Asn Thr Leu Ala Ser His Gly Tyr Leu 
        35                  40                  45              


Pro Arg Asn Gly Val Ala Thr Pro Ala Gln Ile Ile Asn Ala Val Gln 
    50                  55                  60                  


Glu Gly Phe Asn Phe Asp Asn Gln Ala Ala Ile Phe Ala Thr Tyr Ala 
65                  70                  75                  80  


Ala His Leu Val Asp Gly Asn Leu Ile Thr Asp Leu Leu Ser Ile Gly 
                85                  90                  95      


Arg Lys Thr Arg Leu Thr Gly Pro Asp Pro Pro Pro Pro Ala Ser Val 
            100                 105                 110         


Gly Gly Leu Asn Glu His Gly Thr Phe Glu Gly Asp Ala Ser Met Thr 
        115                 120                 125             


Arg Gly Asp Ala Phe Phe Gly Asn Asn His Asp Phe Asn Glu Thr Leu 
    130                 135                 140                 


Phe Glu Gln Leu Val Asp Tyr Ser Asn Arg Phe Gly Gly Gly Lys Tyr 
145                 150                 155                 160 


Asn Leu Thr Val Ala Gly Glu Leu Arg Phe Lys Arg Ile Gln Asp Ser 
                165                 170                 175     


Ile Ala Thr Asn Pro Asn Phe Ser Phe Val Asp Phe Arg Phe Phe Thr 
            180                 185                 190         


Ala Tyr Gly Glu Thr Thr Phe Pro Ala Asn Leu Phe Val Asp Gly Arg 
        195                 200                 205             


Arg Asp Asp Gly Gln Leu Asp Met Asp Ala Ala Arg Ser Phe Phe Gln 
    210                 215                 220                 


Phe Ser Arg Met Pro Asp Asp Phe Phe Arg Ala Pro Ser Pro Arg Ser 
225                 230                 235                 240 


Gly Thr Gly Val Glu Val Val Val Gln Ala His Pro Met Gln Pro Gly 
                245                 250                 255     


Arg Asn Val Gly Lys Ile Asn Ser Tyr Thr Val Asp Pro Thr Ser Ser 
            260                 265                 270         


Asp Phe Ser Thr Pro Cys Leu Met Tyr Glu Lys Phe Val Asn Ile Thr 
        275                 280                 285             


Val Lys Ser Leu Tyr Pro Asn Pro Thr Val Gln Leu Arg Lys Ala Leu 
    290                 295                 300                 


Asn Thr Asn Leu Asp Phe Leu Phe Gln Gly Val Ala Ala Gly Cys Thr 
305                 310                 315                 320 


Gln Val Phe Pro Tyr Gly Arg Asp 
                325             


<210>  15
<211>  1113
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variante PaDa-I con pptido seal silvestre


<220>
<221>  CDS
<222>  (1)..(1113)

<220>
<221>  mat_peptide
<222>  (130)..(1113)

<400>  15
atg aaa tat ttt ccc ctg ttc cca acc ttg gtc ttc gca gcg agg gtc         48
Met Lys Tyr Phe Pro Leu Phe Pro Thr Leu Val Phe Ala Ala Arg Val           
            -40                 -35                 -30                   

gtt gct ttt cct gcc tac gcc tca ttg gcc ggc ctc agc cag cag gaa         96
Val Ala Phe Pro Ala Tyr Ala Ser Leu Ala Gly Leu Ser Gln Gln Glu           
        -25                 -20                 -15                       

ttg gac gct ata atc cca aca ctc gag gcc cga gag cca gga tta cct        144
Leu Asp Ala Ile Ile Pro Thr Leu Glu Ala Arg Glu Pro Gly Leu Pro           
    -10                 -5              -1  1               5             

cct ggt cct ctc gag aat agc tct gca aag ttg gtg aac gac gag gct        192
Pro Gly Pro Leu Glu Asn Ser Ser Ala Lys Leu Val Asn Asp Glu Ala           
                10                  15                  20                

cac cca tgg aag ccg ctt cga cct ggc gat att cgt gga cct tgc cct        240
His Pro Trp Lys Pro Leu Arg Pro Gly Asp Ile Arg Gly Pro Cys Pro           
            25                  30                  35                    

ggt ctc aat act ctg gca tct cac ggg tac ctc ccg aga aat ggc gtt        288
Gly Leu Asn Thr Leu Ala Ser His Gly Tyr Leu Pro Arg Asn Gly Val           
        40                  45                  50                        

gca acc ccg gcg caa ata ata aac gcg gtt cag gaa gga ttc aat ttc        336
Ala Thr Pro Ala Gln Ile Ile Asn Ala Val Gln Glu Gly Phe Asn Phe           
    55                  60                  65                            

gac aat caa gcc gca atc ttc gcc aca tat gcg gcc cac ctt gtg gac        384
Asp Asn Gln Ala Ala Ile Phe Ala Thr Tyr Ala Ala His Leu Val Asp           
70                  75                  80                  85            

ggc aat ctc att acg gac ttg ctg agc atc gga cgc aag acg cgg ctc        432
Gly Asn Leu Ile Thr Asp Leu Leu Ser Ile Gly Arg Lys Thr Arg Leu           
                90                  95                  100               

act ggg cct gat cca cca ccc ccc gct tcc gtt ggt gga ctc aat gag        480
Thr Gly Pro Asp Pro Pro Pro Pro Ala Ser Val Gly Gly Leu Asn Glu           
            105                 110                 115                   

cat ggc acc ttc gaa ggc gac gcc agt atg acc cga ggt gac gca ttc        528
His Gly Thr Phe Glu Gly Asp Ala Ser Met Thr Arg Gly Asp Ala Phe           
        120                 125                 130                       

ttt ggc aac aac cac gat ttc aat gag acg ctc ttc gaa cag ttg gtt        576
Phe Gly Asn Asn His Asp Phe Asn Glu Thr Leu Phe Glu Gln Leu Val           
    135                 140                 145                           

gac tac agc aac cga ttt gga gga gga aaa tac aat ctt acc gtc gcg        624
Asp Tyr Ser Asn Arg Phe Gly Gly Gly Lys Tyr Asn Leu Thr Val Ala           
150                 155                 160                 165           

ggg gag ctc cgt ttc aag cgc att caa gac tcc att gcg acc aac ccc        672
Gly Glu Leu Arg Phe Lys Arg Ile Gln Asp Ser Ile Ala Thr Asn Pro           
                170                 175                 180               

aat ttc tcc ttt gtt gac ttt agg ttc ttt act gct tac ggc gag acc        720
Asn Phe Ser Phe Val Asp Phe Arg Phe Phe Thr Ala Tyr Gly Glu Thr           
            185                 190                 195                   

acc ttc ccc gcg aat ctt ttt gtg gat ggg cgc agg gac gac ggc cag        768
Thr Phe Pro Ala Asn Leu Phe Val Asp Gly Arg Arg Asp Asp Gly Gln           
        200                 205                 210                       

cta gat atg gat gct gca cgg agt ttt ttc caa ttc agc cgt atg cct        816
Leu Asp Met Asp Ala Ala Arg Ser Phe Phe Gln Phe Ser Arg Met Pro           
    215                 220                 225                           

gac gat ttc ttc cgc gca ccc agc ccg aga agt ggc aca gga gtc gag        864
Asp Asp Phe Phe Arg Ala Pro Ser Pro Arg Ser Gly Thr Gly Val Glu           
230                 235                 240                 245           

gta gtt gta cag gct cat cct atg cag ccc gga aga aat gtc ggc aag        912
Val Val Val Gln Ala His Pro Met Gln Pro Gly Arg Asn Val Gly Lys           
                250                 255                 260               

atc aac agc tac acc gtc gac cca aca tcc tct gac ttt tcc acc ccc        960
Ile Asn Ser Tyr Thr Val Asp Pro Thr Ser Ser Asp Phe Ser Thr Pro           
            265                 270                 275                   

tgc ttg atg tac gag aaa ttc gtc aac ata acg gtc aag tca ctc tac       1008
Cys Leu Met Tyr Glu Lys Phe Val Asn Ile Thr Val Lys Ser Leu Tyr           
        280                 285                 290                       

ccg aat ccg acg gtg cag ctt cgc aaa gcc ctt aat acg aat ctc gat       1056
Pro Asn Pro Thr Val Gln Leu Arg Lys Ala Leu Asn Thr Asn Leu Asp           
    295                 300                 305                           

ttc tta ttc cag gga gtc gcc gct gga tgt acc cag gtc ttc cca tac       1104
Phe Leu Phe Gln Gly Val Ala Ala Gly Cys Thr Gln Val Phe Pro Tyr           
310                 315                 320                 325           

ggg cga gat                                                           1113
Gly Arg Asp                                                               
                                                                          


<210>  16
<211>  371
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  16

Met Lys Tyr Phe Pro Leu Phe Pro Thr Leu Val Phe Ala Ala Arg Val 
            -40                 -35                 -30         


Val Ala Phe Pro Ala Tyr Ala Ser Leu Ala Gly Leu Ser Gln Gln Glu 
        -25                 -20                 -15             


Leu Asp Ala Ile Ile Pro Thr Leu Glu Ala Arg Glu Pro Gly Leu Pro 
    -10                 -5              -1  1               5   


Pro Gly Pro Leu Glu Asn Ser Ser Ala Lys Leu Val Asn Asp Glu Ala 
                10                  15                  20      


His Pro Trp Lys Pro Leu Arg Pro Gly Asp Ile Arg Gly Pro Cys Pro 
            25                  30                  35          


Gly Leu Asn Thr Leu Ala Ser His Gly Tyr Leu Pro Arg Asn Gly Val 
        40                  45                  50              


Ala Thr Pro Ala Gln Ile Ile Asn Ala Val Gln Glu Gly Phe Asn Phe 
    55                  60                  65                  


Asp Asn Gln Ala Ala Ile Phe Ala Thr Tyr Ala Ala His Leu Val Asp 
70                  75                  80                  85  


Gly Asn Leu Ile Thr Asp Leu Leu Ser Ile Gly Arg Lys Thr Arg Leu 
                90                  95                  100     


Thr Gly Pro Asp Pro Pro Pro Pro Ala Ser Val Gly Gly Leu Asn Glu 
            105                 110                 115         


His Gly Thr Phe Glu Gly Asp Ala Ser Met Thr Arg Gly Asp Ala Phe 
        120                 125                 130             


Phe Gly Asn Asn His Asp Phe Asn Glu Thr Leu Phe Glu Gln Leu Val 
    135                 140                 145                 


Asp Tyr Ser Asn Arg Phe Gly Gly Gly Lys Tyr Asn Leu Thr Val Ala 
150                 155                 160                 165 


Gly Glu Leu Arg Phe Lys Arg Ile Gln Asp Ser Ile Ala Thr Asn Pro 
                170                 175                 180     


Asn Phe Ser Phe Val Asp Phe Arg Phe Phe Thr Ala Tyr Gly Glu Thr 
            185                 190                 195         


Thr Phe Pro Ala Asn Leu Phe Val Asp Gly Arg Arg Asp Asp Gly Gln 
        200                 205                 210             


Leu Asp Met Asp Ala Ala Arg Ser Phe Phe Gln Phe Ser Arg Met Pro 
    215                 220                 225                 


Asp Asp Phe Phe Arg Ala Pro Ser Pro Arg Ser Gly Thr Gly Val Glu 
230                 235                 240                 245 


Val Val Val Gln Ala His Pro Met Gln Pro Gly Arg Asn Val Gly Lys 
                250                 255                 260     


Ile Asn Ser Tyr Thr Val Asp Pro Thr Ser Ser Asp Phe Ser Thr Pro 
            265                 270                 275         


Cys Leu Met Tyr Glu Lys Phe Val Asn Ile Thr Val Lys Ser Leu Tyr 
        280                 285                 290             


Pro Asn Pro Thr Val Gln Leu Arg Lys Ala Leu Asn Thr Asn Leu Asp 
    295                 300                 305                 


Phe Leu Phe Gln Gly Val Ala Ala Gly Cys Thr Gln Val Phe Pro Tyr 
310                 315                 320                 325 


Gly Arg Asp 
            


<210>  17
<211>  1113
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variante PaDa-I con el pptido seal modificado


<220>
<221>  CDS
<222>  (1)..(1113)

<220>
<221>  mat_peptide
<222>  (130)..(1113)

<400>  17
atg aaa tat ttt ccc ctg ttc cca acc ttg gtc tac gca gtg ggg gtc         48
Met Lys Tyr Phe Pro Leu Phe Pro Thr Leu Val Tyr Ala Val Gly Val           
            -40                 -35                 -30                   

gtt gct ttt cct gac tac gcc tca ttg gcc ggc ctc agc cag cag gaa         96
Val Ala Phe Pro Asp Tyr Ala Ser Leu Ala Gly Leu Ser Gln Gln Glu           
        -25                 -20                 -15                       

ttg gac gct ata atc cca aca ctc gag gcc cga gag cca gga tta cct        144
Leu Asp Ala Ile Ile Pro Thr Leu Glu Ala Arg Glu Pro Gly Leu Pro           
    -10                 -5              -1  1               5             

cct ggt cct ctc gag aat agc tct gca aag ttg gtg aac gac gag gct        192
Pro Gly Pro Leu Glu Asn Ser Ser Ala Lys Leu Val Asn Asp Glu Ala           
                10                  15                  20                

cac cca tgg aag ccg ctt cga cct ggc gat att cgt gga cct tgc cct        240
His Pro Trp Lys Pro Leu Arg Pro Gly Asp Ile Arg Gly Pro Cys Pro           
            25                  30                  35                    

ggt ctc aat act ctg gca tct cac ggg tac ctc ccg aga aat ggc gtt        288
Gly Leu Asn Thr Leu Ala Ser His Gly Tyr Leu Pro Arg Asn Gly Val           
        40                  45                  50                        

gca acc ccg gcg caa ata ata aac gcg gtt cag gaa gga ttc aat ttc        336
Ala Thr Pro Ala Gln Ile Ile Asn Ala Val Gln Glu Gly Phe Asn Phe           
    55                  60                  65                            

gac aat caa gcc gca atc ttc gcc aca tat gcg gcc cac ctt gtg gac        384
Asp Asn Gln Ala Ala Ile Phe Ala Thr Tyr Ala Ala His Leu Val Asp           
70                  75                  80                  85            

ggc aat ctc att acg gac ttg ctg agc atc gga cgc aag acg cgg ctc        432
Gly Asn Leu Ile Thr Asp Leu Leu Ser Ile Gly Arg Lys Thr Arg Leu           
                90                  95                  100               

act ggg cct gat cca cca ccc ccc gct tcc gtt ggt gga ctc aat gag        480
Thr Gly Pro Asp Pro Pro Pro Pro Ala Ser Val Gly Gly Leu Asn Glu           
            105                 110                 115                   

cat ggc acc ttc gaa ggc gac gcc agt atg acc cga ggt gac gca ttc        528
His Gly Thr Phe Glu Gly Asp Ala Ser Met Thr Arg Gly Asp Ala Phe           
        120                 125                 130                       

ttt ggc aac aac cac gat ttc aat gag acg ctc ttc gaa cag ttg gtt        576
Phe Gly Asn Asn His Asp Phe Asn Glu Thr Leu Phe Glu Gln Leu Val           
    135                 140                 145                           

gac tac agc aac cga ttt gga gga gga aaa tac aat ctt acc gtc gcg        624
Asp Tyr Ser Asn Arg Phe Gly Gly Gly Lys Tyr Asn Leu Thr Val Ala           
150                 155                 160                 165           

ggg gag ctc cgt ttc aag cgc att caa gac tcc att gcg acc aac ccc        672
Gly Glu Leu Arg Phe Lys Arg Ile Gln Asp Ser Ile Ala Thr Asn Pro           
                170                 175                 180               

aat ttc tcc ttt gtt gac ttt agg ttc ttt act gct tac ggc gag acc        720
Asn Phe Ser Phe Val Asp Phe Arg Phe Phe Thr Ala Tyr Gly Glu Thr           
            185                 190                 195                   

acc ttc ccc gcg aat ctt ttt gtg gat ggg cgc agg gac gac ggc cag        768
Thr Phe Pro Ala Asn Leu Phe Val Asp Gly Arg Arg Asp Asp Gly Gln           
        200                 205                 210                       

cta gat atg gat gct gca cgg agt ttt ttc caa ttc agc cgt atg cct        816
Leu Asp Met Asp Ala Ala Arg Ser Phe Phe Gln Phe Ser Arg Met Pro           
    215                 220                 225                           

gac gat ttc ttc cgc gca ccc agc ccg aga agt ggc aca gga gtc gag        864
Asp Asp Phe Phe Arg Ala Pro Ser Pro Arg Ser Gly Thr Gly Val Glu           
230                 235                 240                 245           

gta gtt gta cag gct cat cct atg cag ccc gga aga aat gtc ggc aag        912
Val Val Val Gln Ala His Pro Met Gln Pro Gly Arg Asn Val Gly Lys           
                250                 255                 260               

atc aac agc tac acc gtc gac cca aca tcc tct gac ttt tcc acc ccc        960
Ile Asn Ser Tyr Thr Val Asp Pro Thr Ser Ser Asp Phe Ser Thr Pro           
            265                 270                 275                   

tgc ttg atg tac gag aaa ttc gtc aac ata acg gtc aag tca ctc tac       1008
Cys Leu Met Tyr Glu Lys Phe Val Asn Ile Thr Val Lys Ser Leu Tyr           
        280                 285                 290                       

ccg aat ccg acg gtg cag ctt cgc aaa gcc ctt aat acg aat ctc gat       1056
Pro Asn Pro Thr Val Gln Leu Arg Lys Ala Leu Asn Thr Asn Leu Asp           
    295                 300                 305                           

ttc tta ttc cag gga gtc gcc gct gga tgt acc cag gtc ttc cca tac       1104
Phe Leu Phe Gln Gly Val Ala Ala Gly Cys Thr Gln Val Phe Pro Tyr           
310                 315                 320                 325           

ggg cga gat                                                           1113
Gly Arg Asp                                                               
                                                                          


<210>  18
<211>  371
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  18

Met Lys Tyr Phe Pro Leu Phe Pro Thr Leu Val Tyr Ala Val Gly Val 
            -40                 -35                 -30         


Val Ala Phe Pro Asp Tyr Ala Ser Leu Ala Gly Leu Ser Gln Gln Glu 
        -25                 -20                 -15             


Leu Asp Ala Ile Ile Pro Thr Leu Glu Ala Arg Glu Pro Gly Leu Pro 
    -10                 -5              -1  1               5   


Pro Gly Pro Leu Glu Asn Ser Ser Ala Lys Leu Val Asn Asp Glu Ala 
                10                  15                  20      


His Pro Trp Lys Pro Leu Arg Pro Gly Asp Ile Arg Gly Pro Cys Pro 
            25                  30                  35          


Gly Leu Asn Thr Leu Ala Ser His Gly Tyr Leu Pro Arg Asn Gly Val 
        40                  45                  50              


Ala Thr Pro Ala Gln Ile Ile Asn Ala Val Gln Glu Gly Phe Asn Phe 
    55                  60                  65                  


Asp Asn Gln Ala Ala Ile Phe Ala Thr Tyr Ala Ala His Leu Val Asp 
70                  75                  80                  85  


Gly Asn Leu Ile Thr Asp Leu Leu Ser Ile Gly Arg Lys Thr Arg Leu 
                90                  95                  100     


Thr Gly Pro Asp Pro Pro Pro Pro Ala Ser Val Gly Gly Leu Asn Glu 
            105                 110                 115         


His Gly Thr Phe Glu Gly Asp Ala Ser Met Thr Arg Gly Asp Ala Phe 
        120                 125                 130             


Phe Gly Asn Asn His Asp Phe Asn Glu Thr Leu Phe Glu Gln Leu Val 
    135                 140                 145                 


Asp Tyr Ser Asn Arg Phe Gly Gly Gly Lys Tyr Asn Leu Thr Val Ala 
150                 155                 160                 165 


Gly Glu Leu Arg Phe Lys Arg Ile Gln Asp Ser Ile Ala Thr Asn Pro 
                170                 175                 180     


Asn Phe Ser Phe Val Asp Phe Arg Phe Phe Thr Ala Tyr Gly Glu Thr 
            185                 190                 195         


Thr Phe Pro Ala Asn Leu Phe Val Asp Gly Arg Arg Asp Asp Gly Gln 
        200                 205                 210             


Leu Asp Met Asp Ala Ala Arg Ser Phe Phe Gln Phe Ser Arg Met Pro 
    215                 220                 225                 


Asp Asp Phe Phe Arg Ala Pro Ser Pro Arg Ser Gly Thr Gly Val Glu 
230                 235                 240                 245 


Val Val Val Gln Ala His Pro Met Gln Pro Gly Arg Asn Val Gly Lys 
                250                 255                 260     


Ile Asn Ser Tyr Thr Val Asp Pro Thr Ser Ser Asp Phe Ser Thr Pro 
            265                 270                 275         


Cys Leu Met Tyr Glu Lys Phe Val Asn Ile Thr Val Lys Ser Leu Tyr 
        280                 285                 290             


Pro Asn Pro Thr Val Gln Leu Arg Lys Ala Leu Asn Thr Asn Leu Asp 
    295                 300                 305                 


Phe Leu Phe Gln Gly Val Ala Ala Gly Cys Thr Gln Val Phe Pro Tyr 
310                 315                 320                 325 


Gly Arg Asp 
            


<210>  19
<211>  984
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Varinate JaWa sin pptido seal


<220>
<221>  CDS
<222>  (1)..(984)

<400>  19
gag cca gga tta cct cct ggt cct ctc gag aat agc tct gca aag ttg         48
Glu Pro Gly Leu Pro Pro Gly Pro Leu Glu Asn Ser Ser Ala Lys Leu           
1               5                   10                  15                

gtg aac gac gag gct cac cca tgg aag ccg ctt cga cct ggc gat att         96
Val Asn Asp Glu Ala His Pro Trp Lys Pro Leu Arg Pro Gly Asp Ile           
            20                  25                  30                    

cgt gga cct tgc cct ggt ctc aat act ctg gca tct cac ggg tac ctc        144
Arg Gly Pro Cys Pro Gly Leu Asn Thr Leu Ala Ser His Gly Tyr Leu           
        35                  40                  45                        

ccg aga aat ggc gtt gca acc ccg gcg caa ata ata aac gcg gtt cag        192
Pro Arg Asn Gly Val Ala Thr Pro Ala Gln Ile Ile Asn Ala Val Gln           
    50                  55                  60                            

gaa gga ttc aat ttc gac aat caa gcc gca atc ttc gcc aca tat gcg        240
Glu Gly Phe Asn Phe Asp Asn Gln Ala Ala Ile Phe Ala Thr Tyr Ala           
65                  70                  75                  80            

gcc cac ctt gtg gac ggc aat ctc att acg gac ttg ctg agc atc gga        288
Ala His Leu Val Asp Gly Asn Leu Ile Thr Asp Leu Leu Ser Ile Gly           
                85                  90                  95                

cgc aag acg cgg ctc act ggg cct gat cca cca ccc ccc gct tcc gtt        336
Arg Lys Thr Arg Leu Thr Gly Pro Asp Pro Pro Pro Pro Ala Ser Val           
            100                 105                 110                   

ggt gga ctc aat gag cat ggc acc ttc gaa ggc gac gcc agt atg acc        384
Gly Gly Leu Asn Glu His Gly Thr Phe Glu Gly Asp Ala Ser Met Thr           
        115                 120                 125                       

cga ggt gac gca ttc ttt ggc aac aac cac gat ttc aat gag acg ctc        432
Arg Gly Asp Ala Phe Phe Gly Asn Asn His Asp Phe Asn Glu Thr Leu           
    130                 135                 140                           

ttc gaa cag ttg gtt gac tac agc aac cga ttt gga gga gga aaa tac        480
Phe Glu Gln Leu Val Asp Tyr Ser Asn Arg Phe Gly Gly Gly Lys Tyr           
145                 150                 155                 160           

aat ctt acc gtc gcg ggg gag ctc cgt ttc aag cgc att caa gac tcc        528
Asn Leu Thr Val Ala Gly Glu Leu Arg Phe Lys Arg Ile Gln Asp Ser           
                165                 170                 175               

att gcg acc aac ccc aat ttc tcc ttt gtt gac ttt agg ttc ttt act        576
Ile Ala Thr Asn Pro Asn Phe Ser Phe Val Asp Phe Arg Phe Phe Thr           
            180                 185                 190                   

gct tac ggc gag acc acc ttc ccc gcg aat ctt ttt gtg gat ggg cgc        624
Ala Tyr Gly Glu Thr Thr Phe Pro Ala Asn Leu Phe Val Asp Gly Arg           
        195                 200                 205                       

agg gac gac ggc cag cta gat atg gat gct gca cgg agt ttt ttc caa        672
Arg Asp Asp Gly Gln Leu Asp Met Asp Ala Ala Arg Ser Phe Phe Gln           
    210                 215                 220                           

ttc agc cgt atg cct gac gat ttc ttc cgc gca ccc agc ccg aga agt        720
Phe Ser Arg Met Pro Asp Asp Phe Phe Arg Ala Pro Ser Pro Arg Ser           
225                 230                 235                 240           

gac aca gga gtc gag gta gtt gta cag gct cat cct atg cag ccc gga        768
Asp Thr Gly Val Glu Val Val Val Gln Ala His Pro Met Gln Pro Gly           
                245                 250                 255               

aaa aat gtc ggc aag atc aac agc tac acc gtc gac cca aca tcc tct        816
Lys Asn Val Gly Lys Ile Asn Ser Tyr Thr Val Asp Pro Thr Ser Ser           
            260                 265                 270                   

gac ttt tcc acc ccc tgc ttg atg tac gag aaa ttc gtc aac ata acg        864
Asp Phe Ser Thr Pro Cys Leu Met Tyr Glu Lys Phe Val Asn Ile Thr           
        275                 280                 285                       

gtc aag tca ctc tac ccg aat ccg acg gtg cag ctt cgc aaa gcc ctt        912
Val Lys Ser Leu Tyr Pro Asn Pro Thr Val Gln Leu Arg Lys Ala Leu           
    290                 295                 300                           

aat acg aat ctc gat ttc tta ttc cag gga gtc gcc gct gga tgt acc        960
Asn Thr Asn Leu Asp Phe Leu Phe Gln Gly Val Ala Ala Gly Cys Thr           
305                 310                 315                 320           

cag gtc ttc cca tac ggg cga gat                                        984
Gln Val Phe Pro Tyr Gly Arg Asp                                           
                325                                                       


<210>  20
<211>  328
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  20

Glu Pro Gly Leu Pro Pro Gly Pro Leu Glu Asn Ser Ser Ala Lys Leu 
1               5                   10                  15      


Val Asn Asp Glu Ala His Pro Trp Lys Pro Leu Arg Pro Gly Asp Ile 
            20                  25                  30          


Arg Gly Pro Cys Pro Gly Leu Asn Thr Leu Ala Ser His Gly Tyr Leu 
        35                  40                  45              


Pro Arg Asn Gly Val Ala Thr Pro Ala Gln Ile Ile Asn Ala Val Gln 
    50                  55                  60                  


Glu Gly Phe Asn Phe Asp Asn Gln Ala Ala Ile Phe Ala Thr Tyr Ala 
65                  70                  75                  80  


Ala His Leu Val Asp Gly Asn Leu Ile Thr Asp Leu Leu Ser Ile Gly 
                85                  90                  95      


Arg Lys Thr Arg Leu Thr Gly Pro Asp Pro Pro Pro Pro Ala Ser Val 
            100                 105                 110         


Gly Gly Leu Asn Glu His Gly Thr Phe Glu Gly Asp Ala Ser Met Thr 
        115                 120                 125             


Arg Gly Asp Ala Phe Phe Gly Asn Asn His Asp Phe Asn Glu Thr Leu 
    130                 135                 140                 


Phe Glu Gln Leu Val Asp Tyr Ser Asn Arg Phe Gly Gly Gly Lys Tyr 
145                 150                 155                 160 


Asn Leu Thr Val Ala Gly Glu Leu Arg Phe Lys Arg Ile Gln Asp Ser 
                165                 170                 175     


Ile Ala Thr Asn Pro Asn Phe Ser Phe Val Asp Phe Arg Phe Phe Thr 
            180                 185                 190         


Ala Tyr Gly Glu Thr Thr Phe Pro Ala Asn Leu Phe Val Asp Gly Arg 
        195                 200                 205             


Arg Asp Asp Gly Gln Leu Asp Met Asp Ala Ala Arg Ser Phe Phe Gln 
    210                 215                 220                 


Phe Ser Arg Met Pro Asp Asp Phe Phe Arg Ala Pro Ser Pro Arg Ser 
225                 230                 235                 240 


Asp Thr Gly Val Glu Val Val Val Gln Ala His Pro Met Gln Pro Gly 
                245                 250                 255     


Lys Asn Val Gly Lys Ile Asn Ser Tyr Thr Val Asp Pro Thr Ser Ser 
            260                 265                 270         


Asp Phe Ser Thr Pro Cys Leu Met Tyr Glu Lys Phe Val Asn Ile Thr 
        275                 280                 285             


Val Lys Ser Leu Tyr Pro Asn Pro Thr Val Gln Leu Arg Lys Ala Leu 
    290                 295                 300                 


Asn Thr Asn Leu Asp Phe Leu Phe Gln Gly Val Ala Ala Gly Cys Thr 
305                 310                 315                 320 


Gln Val Phe Pro Tyr Gly Arg Asp 
                325             


<210>  21
<211>  1113
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variante JaWa con pptido seal silvestre


<220>
<221>  CDS
<222>  (1)..(1113)

<220>
<221>  mat_peptide
<222>  (130)..(1113)

<400>  21
atg aaa tat ttt ccc ctg ttc cca acc ttg gtc ttc gca gcg agg gtc         48
Met Lys Tyr Phe Pro Leu Phe Pro Thr Leu Val Phe Ala Ala Arg Val           
            -40                 -35                 -30                   

gtt gct ttt cct gcc tac gcc tca ttg gcc ggc ctc agc cag cag gaa         96
Val Ala Phe Pro Ala Tyr Ala Ser Leu Ala Gly Leu Ser Gln Gln Glu           
        -25                 -20                 -15                       

ttg gac gct ata atc cca aca ctc gag gcc cga gag cca gga tta cct        144
Leu Asp Ala Ile Ile Pro Thr Leu Glu Ala Arg Glu Pro Gly Leu Pro           
    -10                 -5              -1  1               5             

cct ggt cct ctc gag aat agc tct gca aag ttg gtg aac gac gag gct        192
Pro Gly Pro Leu Glu Asn Ser Ser Ala Lys Leu Val Asn Asp Glu Ala           
                10                  15                  20                

cac cca tgg aag ccg ctt cga cct ggc gat att cgt gga cct tgc cct        240
His Pro Trp Lys Pro Leu Arg Pro Gly Asp Ile Arg Gly Pro Cys Pro           
            25                  30                  35                    

ggt ctc aat act ctg gca tct cac ggg tac ctc ccg aga aat ggc gtt        288
Gly Leu Asn Thr Leu Ala Ser His Gly Tyr Leu Pro Arg Asn Gly Val           
        40                  45                  50                        

gca acc ccg gcg caa ata ata aac gcg gtt cag gaa gga ttc aat ttc        336
Ala Thr Pro Ala Gln Ile Ile Asn Ala Val Gln Glu Gly Phe Asn Phe           
    55                  60                  65                            

gac aat caa gcc gca atc ttc gcc aca tat gcg gcc cac ctt gtg gac        384
Asp Asn Gln Ala Ala Ile Phe Ala Thr Tyr Ala Ala His Leu Val Asp           
70                  75                  80                  85            

ggc aat ctc att acg gac ttg ctg agc atc gga cgc aag acg cgg ctc        432
Gly Asn Leu Ile Thr Asp Leu Leu Ser Ile Gly Arg Lys Thr Arg Leu           
                90                  95                  100               

act ggg cct gat cca cca ccc ccc gct tcc gtt ggt gga ctc aat gag        480
Thr Gly Pro Asp Pro Pro Pro Pro Ala Ser Val Gly Gly Leu Asn Glu           
            105                 110                 115                   

cat ggc acc ttc gaa ggc gac gcc agt atg acc cga ggt gac gca ttc        528
His Gly Thr Phe Glu Gly Asp Ala Ser Met Thr Arg Gly Asp Ala Phe           
        120                 125                 130                       

ttt ggc aac aac cac gat ttc aat gag acg ctc ttc gaa cag ttg gtt        576
Phe Gly Asn Asn His Asp Phe Asn Glu Thr Leu Phe Glu Gln Leu Val           
    135                 140                 145                           

gac tac agc aac cga ttt gga gga gga aaa tac aat ctt acc gtc gcg        624
Asp Tyr Ser Asn Arg Phe Gly Gly Gly Lys Tyr Asn Leu Thr Val Ala           
150                 155                 160                 165           

ggg gag ctc cgt ttc aag cgc att caa gac tcc att gcg acc aac ccc        672
Gly Glu Leu Arg Phe Lys Arg Ile Gln Asp Ser Ile Ala Thr Asn Pro           
                170                 175                 180               

aat ttc tcc ttt gtt gac ttt agg ttc ttt act gct tac ggc gag acc        720
Asn Phe Ser Phe Val Asp Phe Arg Phe Phe Thr Ala Tyr Gly Glu Thr           
            185                 190                 195                   

acc ttc ccc gcg aat ctt ttt gtg gat ggg cgc agg gac gac ggc cag        768
Thr Phe Pro Ala Asn Leu Phe Val Asp Gly Arg Arg Asp Asp Gly Gln           
        200                 205                 210                       

cta gat atg gat gct gca cgg agt ttt ttc caa ttc agc cgt atg cct        816
Leu Asp Met Asp Ala Ala Arg Ser Phe Phe Gln Phe Ser Arg Met Pro           
    215                 220                 225                           

gac gat ttc ttc cgc gca ccc agc ccg aga agt gac aca gga gtc gag        864
Asp Asp Phe Phe Arg Ala Pro Ser Pro Arg Ser Asp Thr Gly Val Glu           
230                 235                 240                 245           

gta gtt gta cag gct cat cct atg cag ccc gga aaa aat gtc ggc aag        912
Val Val Val Gln Ala His Pro Met Gln Pro Gly Lys Asn Val Gly Lys           
                250                 255                 260               

atc aac agc tac acc gtc gac cca aca tcc tct gac ttt tcc acc ccc        960
Ile Asn Ser Tyr Thr Val Asp Pro Thr Ser Ser Asp Phe Ser Thr Pro           
            265                 270                 275                   

tgc ttg atg tac gag aaa ttc gtc aac ata acg gtc aag tca ctc tac       1008
Cys Leu Met Tyr Glu Lys Phe Val Asn Ile Thr Val Lys Ser Leu Tyr           
        280                 285                 290                       

ccg aat ccg acg gtg cag ctt cgc aaa gcc ctt aat acg aat ctc gat       1056
Pro Asn Pro Thr Val Gln Leu Arg Lys Ala Leu Asn Thr Asn Leu Asp           
    295                 300                 305                           

ttc tta ttc cag gga gtc gcc gct gga tgt acc cag gtc ttc cca tac       1104
Phe Leu Phe Gln Gly Val Ala Ala Gly Cys Thr Gln Val Phe Pro Tyr           
310                 315                 320                 325           

ggg cga gat                                                           1113
Gly Arg Asp                                                               
                                                                          


<210>  22
<211>  371
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  22

Met Lys Tyr Phe Pro Leu Phe Pro Thr Leu Val Phe Ala Ala Arg Val 
            -40                 -35                 -30         


Val Ala Phe Pro Ala Tyr Ala Ser Leu Ala Gly Leu Ser Gln Gln Glu 
        -25                 -20                 -15             


Leu Asp Ala Ile Ile Pro Thr Leu Glu Ala Arg Glu Pro Gly Leu Pro 
    -10                 -5              -1  1               5   


Pro Gly Pro Leu Glu Asn Ser Ser Ala Lys Leu Val Asn Asp Glu Ala 
                10                  15                  20      


His Pro Trp Lys Pro Leu Arg Pro Gly Asp Ile Arg Gly Pro Cys Pro 
            25                  30                  35          


Gly Leu Asn Thr Leu Ala Ser His Gly Tyr Leu Pro Arg Asn Gly Val 
        40                  45                  50              


Ala Thr Pro Ala Gln Ile Ile Asn Ala Val Gln Glu Gly Phe Asn Phe 
    55                  60                  65                  


Asp Asn Gln Ala Ala Ile Phe Ala Thr Tyr Ala Ala His Leu Val Asp 
70                  75                  80                  85  


Gly Asn Leu Ile Thr Asp Leu Leu Ser Ile Gly Arg Lys Thr Arg Leu 
                90                  95                  100     


Thr Gly Pro Asp Pro Pro Pro Pro Ala Ser Val Gly Gly Leu Asn Glu 
            105                 110                 115         


His Gly Thr Phe Glu Gly Asp Ala Ser Met Thr Arg Gly Asp Ala Phe 
        120                 125                 130             


Phe Gly Asn Asn His Asp Phe Asn Glu Thr Leu Phe Glu Gln Leu Val 
    135                 140                 145                 


Asp Tyr Ser Asn Arg Phe Gly Gly Gly Lys Tyr Asn Leu Thr Val Ala 
150                 155                 160                 165 


Gly Glu Leu Arg Phe Lys Arg Ile Gln Asp Ser Ile Ala Thr Asn Pro 
                170                 175                 180     


Asn Phe Ser Phe Val Asp Phe Arg Phe Phe Thr Ala Tyr Gly Glu Thr 
            185                 190                 195         


Thr Phe Pro Ala Asn Leu Phe Val Asp Gly Arg Arg Asp Asp Gly Gln 
        200                 205                 210             


Leu Asp Met Asp Ala Ala Arg Ser Phe Phe Gln Phe Ser Arg Met Pro 
    215                 220                 225                 


Asp Asp Phe Phe Arg Ala Pro Ser Pro Arg Ser Asp Thr Gly Val Glu 
230                 235                 240                 245 


Val Val Val Gln Ala His Pro Met Gln Pro Gly Lys Asn Val Gly Lys 
                250                 255                 260     


Ile Asn Ser Tyr Thr Val Asp Pro Thr Ser Ser Asp Phe Ser Thr Pro 
            265                 270                 275         


Cys Leu Met Tyr Glu Lys Phe Val Asn Ile Thr Val Lys Ser Leu Tyr 
        280                 285                 290             


Pro Asn Pro Thr Val Gln Leu Arg Lys Ala Leu Asn Thr Asn Leu Asp 
    295                 300                 305                 


Phe Leu Phe Gln Gly Val Ala Ala Gly Cys Thr Gln Val Phe Pro Tyr 
310                 315                 320                 325 


Gly Arg Asp 
            


<210>  23
<211>  1113
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variante JaWa con pptido seal modificdo


<220>
<221>  CDS
<222>  (1)..(1113)

<220>
<221>  mat_peptide
<222>  (130)..(1113)

<400>  23
atg aaa tat ttt ccc ctg ttc cca acc ttg gtc tac gca gtg ggg gtc         48
Met Lys Tyr Phe Pro Leu Phe Pro Thr Leu Val Tyr Ala Val Gly Val           
            -40                 -35                 -30                   

gtt gct ttt cct gac tac gcc tca ttg gcc ggc ctc agc cag cag gaa         96
Val Ala Phe Pro Asp Tyr Ala Ser Leu Ala Gly Leu Ser Gln Gln Glu           
        -25                 -20                 -15                       

ttg gac gct ata atc cca aca ctc gag gcc cga gag cca gga tta cct        144
Leu Asp Ala Ile Ile Pro Thr Leu Glu Ala Arg Glu Pro Gly Leu Pro           
    -10                 -5              -1  1               5             

cct ggt cct ctc gag aat agc tct gca aag ttg gtg aac gac gag gct        192
Pro Gly Pro Leu Glu Asn Ser Ser Ala Lys Leu Val Asn Asp Glu Ala           
                10                  15                  20                

cac cca tgg aag ccg ctt cga cct ggc gat att cgt gga cct tgc cct        240
His Pro Trp Lys Pro Leu Arg Pro Gly Asp Ile Arg Gly Pro Cys Pro           
            25                  30                  35                    

ggt ctc aat act ctg gca tct cac ggg tac ctc ccg aga aat ggc gtt        288
Gly Leu Asn Thr Leu Ala Ser His Gly Tyr Leu Pro Arg Asn Gly Val           
        40                  45                  50                        

gca acc ccg gcg caa ata ata aac gcg gtt cag gaa gga ttc aat ttc        336
Ala Thr Pro Ala Gln Ile Ile Asn Ala Val Gln Glu Gly Phe Asn Phe           
    55                  60                  65                            

gac aat caa gcc gca atc ttc gcc aca tat gcg gcc cac ctt gtg gac        384
Asp Asn Gln Ala Ala Ile Phe Ala Thr Tyr Ala Ala His Leu Val Asp           
70                  75                  80                  85            

ggc aat ctc att acg gac ttg ctg agc atc gga cgc aag acg cgg ctc        432
Gly Asn Leu Ile Thr Asp Leu Leu Ser Ile Gly Arg Lys Thr Arg Leu           
                90                  95                  100               

act ggg cct gat cca cca ccc ccc gct tcc gtt ggt gga ctc aat gag        480
Thr Gly Pro Asp Pro Pro Pro Pro Ala Ser Val Gly Gly Leu Asn Glu           
            105                 110                 115                   

cat ggc acc ttc gaa ggc gac gcc agt atg acc cga ggt gac gca ttc        528
His Gly Thr Phe Glu Gly Asp Ala Ser Met Thr Arg Gly Asp Ala Phe           
        120                 125                 130                       

ttt ggc aac aac cac gat ttc aat gag acg ctc ttc gaa cag ttg gtt        576
Phe Gly Asn Asn His Asp Phe Asn Glu Thr Leu Phe Glu Gln Leu Val           
    135                 140                 145                           

gac tac agc aac cga ttt gga gga gga aaa tac aat ctt acc gtc gcg        624
Asp Tyr Ser Asn Arg Phe Gly Gly Gly Lys Tyr Asn Leu Thr Val Ala           
150                 155                 160                 165           

ggg gag ctc cgt ttc aag cgc att caa gac tcc att gcg acc aac ccc        672
Gly Glu Leu Arg Phe Lys Arg Ile Gln Asp Ser Ile Ala Thr Asn Pro           
                170                 175                 180               

aat ttc tcc ttt gtt gac ttt agg ttc ttt act gct tac ggc gag acc        720
Asn Phe Ser Phe Val Asp Phe Arg Phe Phe Thr Ala Tyr Gly Glu Thr           
            185                 190                 195                   

acc ttc ccc gcg aat ctt ttt gtg gat ggg cgc agg gac gac ggc cag        768
Thr Phe Pro Ala Asn Leu Phe Val Asp Gly Arg Arg Asp Asp Gly Gln           
        200                 205                 210                       

cta gat atg gat gct gca cgg agt ttt ttc caa ttc agc cgt atg cct        816
Leu Asp Met Asp Ala Ala Arg Ser Phe Phe Gln Phe Ser Arg Met Pro           
    215                 220                 225                           

gac gat ttc ttc cgc gca ccc agc ccg aga agt gac aca gga gtc gag        864
Asp Asp Phe Phe Arg Ala Pro Ser Pro Arg Ser Asp Thr Gly Val Glu           
230                 235                 240                 245           

gta gtt gta cag gct cat cct atg cag ccc gga aaa aat gtc ggc aag        912
Val Val Val Gln Ala His Pro Met Gln Pro Gly Lys Asn Val Gly Lys           
                250                 255                 260               

atc aac agc tac acc gtc gac cca aca tcc tct gac ttt tcc acc ccc        960
Ile Asn Ser Tyr Thr Val Asp Pro Thr Ser Ser Asp Phe Ser Thr Pro           
            265                 270                 275                   

tgc ttg atg tac gag aaa ttc gtc aac ata acg gtc aag tca ctc tac       1008
Cys Leu Met Tyr Glu Lys Phe Val Asn Ile Thr Val Lys Ser Leu Tyr           
        280                 285                 290                       

ccg aat ccg acg gtg cag ctt cgc aaa gcc ctt aat acg aat ctc gat       1056
Pro Asn Pro Thr Val Gln Leu Arg Lys Ala Leu Asn Thr Asn Leu Asp           
    295                 300                 305                           

ttc tta ttc cag gga gtc gcc gct gga tgt acc cag gtc ttc cca tac       1104
Phe Leu Phe Gln Gly Val Ala Ala Gly Cys Thr Gln Val Phe Pro Tyr           
310                 315                 320                 325           

ggg cga gat                                                           1113
Gly Arg Asp                                                               
                                                                          


<210>  24
<211>  371
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  24

Met Lys Tyr Phe Pro Leu Phe Pro Thr Leu Val Tyr Ala Val Gly Val 
            -40                 -35                 -30         


Val Ala Phe Pro Asp Tyr Ala Ser Leu Ala Gly Leu Ser Gln Gln Glu 
        -25                 -20                 -15             


Leu Asp Ala Ile Ile Pro Thr Leu Glu Ala Arg Glu Pro Gly Leu Pro 
    -10                 -5              -1  1               5   


Pro Gly Pro Leu Glu Asn Ser Ser Ala Lys Leu Val Asn Asp Glu Ala 
                10                  15                  20      


His Pro Trp Lys Pro Leu Arg Pro Gly Asp Ile Arg Gly Pro Cys Pro 
            25                  30                  35          


Gly Leu Asn Thr Leu Ala Ser His Gly Tyr Leu Pro Arg Asn Gly Val 
        40                  45                  50              


Ala Thr Pro Ala Gln Ile Ile Asn Ala Val Gln Glu Gly Phe Asn Phe 
    55                  60                  65                  


Asp Asn Gln Ala Ala Ile Phe Ala Thr Tyr Ala Ala His Leu Val Asp 
70                  75                  80                  85  


Gly Asn Leu Ile Thr Asp Leu Leu Ser Ile Gly Arg Lys Thr Arg Leu 
                90                  95                  100     


Thr Gly Pro Asp Pro Pro Pro Pro Ala Ser Val Gly Gly Leu Asn Glu 
            105                 110                 115         


His Gly Thr Phe Glu Gly Asp Ala Ser Met Thr Arg Gly Asp Ala Phe 
        120                 125                 130             


Phe Gly Asn Asn His Asp Phe Asn Glu Thr Leu Phe Glu Gln Leu Val 
    135                 140                 145                 


Asp Tyr Ser Asn Arg Phe Gly Gly Gly Lys Tyr Asn Leu Thr Val Ala 
150                 155                 160                 165 


Gly Glu Leu Arg Phe Lys Arg Ile Gln Asp Ser Ile Ala Thr Asn Pro 
                170                 175                 180     


Asn Phe Ser Phe Val Asp Phe Arg Phe Phe Thr Ala Tyr Gly Glu Thr 
            185                 190                 195         


Thr Phe Pro Ala Asn Leu Phe Val Asp Gly Arg Arg Asp Asp Gly Gln 
        200                 205                 210             


Leu Asp Met Asp Ala Ala Arg Ser Phe Phe Gln Phe Ser Arg Met Pro 
    215                 220                 225                 


Asp Asp Phe Phe Arg Ala Pro Ser Pro Arg Ser Asp Thr Gly Val Glu 
230                 235                 240                 245 


Val Val Val Gln Ala His Pro Met Gln Pro Gly Lys Asn Val Gly Lys 
                250                 255                 260     


Ile Asn Ser Tyr Thr Val Asp Pro Thr Ser Ser Asp Phe Ser Thr Pro 
            265                 270                 275         


Cys Leu Met Tyr Glu Lys Phe Val Asn Ile Thr Val Lys Ser Leu Tyr 
        280                 285                 290             


Pro Asn Pro Thr Val Gln Leu Arg Lys Ala Leu Asn Thr Asn Leu Asp 
    295                 300                 305                 


Phe Leu Phe Gln Gly Val Ala Ala Gly Cys Thr Gln Val Phe Pro Tyr 
310                 315                 320                 325 


Gly Arg Asp 
            


<210>  25
<211>  129
<212>  DNA
<213>  Agrocybe aegerita


<220>
<221>  CDS
<222>  (1)..(129)

<400>  25
atg aaa tat ttt ccc ctg ttc cca acc ttg gtc ttc gca gcg agg gtc         48
Met Lys Tyr Phe Pro Leu Phe Pro Thr Leu Val Phe Ala Ala Arg Val           
1               5                   10                  15                

gtt gct ttt cct gcc tac gcc tca ttg gcc ggc ctc agc cag cag gaa         96
Val Ala Phe Pro Ala Tyr Ala Ser Leu Ala Gly Leu Ser Gln Gln Glu           
            20                  25                  30                    

ttg gac gct ata atc cca aca ctc gag gcc cga                            129
Leu Asp Ala Ile Ile Pro Thr Leu Glu Ala Arg                               
        35                  40                                            


<210>  26
<211>  43
<212>  PRT
<213>  Agrocybe aegerita

<400>  26

Met Lys Tyr Phe Pro Leu Phe Pro Thr Leu Val Phe Ala Ala Arg Val 
1               5                   10                  15      


Val Ala Phe Pro Ala Tyr Ala Ser Leu Ala Gly Leu Ser Gln Gln Glu 
            20                  25                  30          


Leu Asp Ala Ile Ile Pro Thr Leu Glu Ala Arg 
        35                  40              


<210>  27
<211>  129
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Pptido seal modificado respecto al pptido seal silvestre 
       procedente de A. aegerita


<220>
<221>  CDS
<222>  (1)..(129)

<400>  27
atg aaa tat ttt ccc ctg ttc cca acc ttg gtc tac gca gtg ggg gtc         48
Met Lys Tyr Phe Pro Leu Phe Pro Thr Leu Val Tyr Ala Val Gly Val           
1               5                   10                  15                

gtt gct ttt cct gac tac gcc tca ttg gcc ggc ctc agc cag cag gaa         96
Val Ala Phe Pro Asp Tyr Ala Ser Leu Ala Gly Leu Ser Gln Gln Glu           
            20                  25                  30                    

ttg gac gct ata atc cca aca ctc gag gcc cga                            129
Leu Asp Ala Ile Ile Pro Thr Leu Glu Ala Arg                               
        35                  40                                            


<210>  28
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  28

Met Lys Tyr Phe Pro Leu Phe Pro Thr Leu Val Tyr Ala Val Gly Val 
1               5                   10                  15      


Val Ala Phe Pro Asp Tyr Ala Ser Leu Ala Gly Leu Ser Gln Gln Glu 
            20                  25                  30          


Leu Asp Ala Ile Ile Pro Thr Leu Glu Ala Arg 
        35                  40              


<210>  29
<211>  1113
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variante W24F obtenida a partir de la variante PaDa-I


<220>
<221>  CDS
<222>  (1)..(1113)

<220>
<221>  mat_peptide
<222>  (130)..(1113)

<400>  29
atg aaa tat ttt ccc ctg ttc cca acc ttg gtc tac gca gtg ggg gtc         48
Met Lys Tyr Phe Pro Leu Phe Pro Thr Leu Val Tyr Ala Val Gly Val           
            -40                 -35                 -30                   

gtt gct ttt cct gac tac gcc tca ttg gcc ggc ctc agc cag cag gaa         96
Val Ala Phe Pro Asp Tyr Ala Ser Leu Ala Gly Leu Ser Gln Gln Glu           
        -25                 -20                 -15                       

ttg gac gct ata atc cca aca ctc gag gcc cga gag cca gga tta cct        144
Leu Asp Ala Ile Ile Pro Thr Leu Glu Ala Arg Glu Pro Gly Leu Pro           
    -10                 -5              -1  1               5             

cct ggt cct ctc gag aat agc tct gca aag ttg gtg aac gac gag gct        192
Pro Gly Pro Leu Glu Asn Ser Ser Ala Lys Leu Val Asn Asp Glu Ala           
                10                  15                  20                

cac cca ttt aag ccg ctt cga cct ggc gat att cgt gga cct tgc cct        240
His Pro Phe Lys Pro Leu Arg Pro Gly Asp Ile Arg Gly Pro Cys Pro           
            25                  30                  35                    

ggt ctc aat act ctg gca tct cac ggg tac ctc ccg aga aat ggc gtt        288
Gly Leu Asn Thr Leu Ala Ser His Gly Tyr Leu Pro Arg Asn Gly Val           
        40                  45                  50                        

gca acc ccg gcg caa ata ata aac gcg gtt cag gaa gga ttc aat ttc        336
Ala Thr Pro Ala Gln Ile Ile Asn Ala Val Gln Glu Gly Phe Asn Phe           
    55                  60                  65                            

gac aat caa gcc gca atc ttc gcc aca tat gcg gcc cac ctt gtg gac        384
Asp Asn Gln Ala Ala Ile Phe Ala Thr Tyr Ala Ala His Leu Val Asp           
70                  75                  80                  85            

ggc aat ctc att acg gac ttg ctg agc atc gga cgc aag acg cgg ctc        432
Gly Asn Leu Ile Thr Asp Leu Leu Ser Ile Gly Arg Lys Thr Arg Leu           
                90                  95                  100               

act ggg cct gat cca cca ccc ccc gct tcc gtt ggt gga ctc aat gag        480
Thr Gly Pro Asp Pro Pro Pro Pro Ala Ser Val Gly Gly Leu Asn Glu           
            105                 110                 115                   

cat ggc acc ttc gaa ggc gac gcc agt atg acc cga ggt gac gca ttc        528
His Gly Thr Phe Glu Gly Asp Ala Ser Met Thr Arg Gly Asp Ala Phe           
        120                 125                 130                       

ttt ggc aac aac cac gat ttc aat gag acg ctc ttc gaa cag ttg gtt        576
Phe Gly Asn Asn His Asp Phe Asn Glu Thr Leu Phe Glu Gln Leu Val           
    135                 140                 145                           

gac tac agc aac cga ttt gga gga gga aaa tac aat ctt acc gtc gcg        624
Asp Tyr Ser Asn Arg Phe Gly Gly Gly Lys Tyr Asn Leu Thr Val Ala           
150                 155                 160                 165           

ggg gag ctc cgt ttc aag cgc att caa gac tcc att gcg acc aac ccc        672
Gly Glu Leu Arg Phe Lys Arg Ile Gln Asp Ser Ile Ala Thr Asn Pro           
                170                 175                 180               

aat ttc tcc ttt gtt gac ttt agg ttc ttt act gct tac ggc gag acc        720
Asn Phe Ser Phe Val Asp Phe Arg Phe Phe Thr Ala Tyr Gly Glu Thr           
            185                 190                 195                   

acc ttc ccc gcg aat ctt ttt gtg gat ggg cgc agg gac gac ggc cag        768
Thr Phe Pro Ala Asn Leu Phe Val Asp Gly Arg Arg Asp Asp Gly Gln           
        200                 205                 210                       

cta gat atg gat gct gca cgg agt ttt ttc caa ttc agc cgt atg cct        816
Leu Asp Met Asp Ala Ala Arg Ser Phe Phe Gln Phe Ser Arg Met Pro           
    215                 220                 225                           

gac gat ttc ttc cgc gca ccc agc ccg aga agt ggc aca gga gtc gag        864
Asp Asp Phe Phe Arg Ala Pro Ser Pro Arg Ser Gly Thr Gly Val Glu           
230                 235                 240                 245           

gta gtt gta cag gct cat cct atg cag ccc gga aga aat gtc ggc aag        912
Val Val Val Gln Ala His Pro Met Gln Pro Gly Arg Asn Val Gly Lys           
                250                 255                 260               

atc aac agc tac acc gtc gac cca aca tcc tct gac ttt tcc acc ccc        960
Ile Asn Ser Tyr Thr Val Asp Pro Thr Ser Ser Asp Phe Ser Thr Pro           
            265                 270                 275                   

tgc ttg atg tac gag aaa ttc gtc aac ata acg gtc aag tca ctc tac       1008
Cys Leu Met Tyr Glu Lys Phe Val Asn Ile Thr Val Lys Ser Leu Tyr           
        280                 285                 290                       

ccg aat ccg acg gtg cag ctt cgc aaa gcc ctt aat acg aat ctc gat       1056
Pro Asn Pro Thr Val Gln Leu Arg Lys Ala Leu Asn Thr Asn Leu Asp           
    295                 300                 305                           

ttc tta ttc cag gga gtc gcc gct gga tgt acc cag gtc ttc cca tac       1104
Phe Leu Phe Gln Gly Val Ala Ala Gly Cys Thr Gln Val Phe Pro Tyr           
310                 315                 320                 325           

ggg cga gat                                                           1113
Gly Arg Asp                                                               
                                                                          


<210>  30
<211>  371
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  30

Met Lys Tyr Phe Pro Leu Phe Pro Thr Leu Val Tyr Ala Val Gly Val 
            -40                 -35                 -30         


Val Ala Phe Pro Asp Tyr Ala Ser Leu Ala Gly Leu Ser Gln Gln Glu 
        -25                 -20                 -15             


Leu Asp Ala Ile Ile Pro Thr Leu Glu Ala Arg Glu Pro Gly Leu Pro 
    -10                 -5              -1  1               5   


Pro Gly Pro Leu Glu Asn Ser Ser Ala Lys Leu Val Asn Asp Glu Ala 
                10                  15                  20      


His Pro Phe Lys Pro Leu Arg Pro Gly Asp Ile Arg Gly Pro Cys Pro 
            25                  30                  35          


Gly Leu Asn Thr Leu Ala Ser His Gly Tyr Leu Pro Arg Asn Gly Val 
        40                  45                  50              


Ala Thr Pro Ala Gln Ile Ile Asn Ala Val Gln Glu Gly Phe Asn Phe 
    55                  60                  65                  


Asp Asn Gln Ala Ala Ile Phe Ala Thr Tyr Ala Ala His Leu Val Asp 
70                  75                  80                  85  


Gly Asn Leu Ile Thr Asp Leu Leu Ser Ile Gly Arg Lys Thr Arg Leu 
                90                  95                  100     


Thr Gly Pro Asp Pro Pro Pro Pro Ala Ser Val Gly Gly Leu Asn Glu 
            105                 110                 115         


His Gly Thr Phe Glu Gly Asp Ala Ser Met Thr Arg Gly Asp Ala Phe 
        120                 125                 130             


Phe Gly Asn Asn His Asp Phe Asn Glu Thr Leu Phe Glu Gln Leu Val 
    135                 140                 145                 


Asp Tyr Ser Asn Arg Phe Gly Gly Gly Lys Tyr Asn Leu Thr Val Ala 
150                 155                 160                 165 


Gly Glu Leu Arg Phe Lys Arg Ile Gln Asp Ser Ile Ala Thr Asn Pro 
                170                 175                 180     


Asn Phe Ser Phe Val Asp Phe Arg Phe Phe Thr Ala Tyr Gly Glu Thr 
            185                 190                 195         


Thr Phe Pro Ala Asn Leu Phe Val Asp Gly Arg Arg Asp Asp Gly Gln 
        200                 205                 210             


Leu Asp Met Asp Ala Ala Arg Ser Phe Phe Gln Phe Ser Arg Met Pro 
    215                 220                 225                 


Asp Asp Phe Phe Arg Ala Pro Ser Pro Arg Ser Gly Thr Gly Val Glu 
230                 235                 240                 245 


Val Val Val Gln Ala His Pro Met Gln Pro Gly Arg Asn Val Gly Lys 
                250                 255                 260     


Ile Asn Ser Tyr Thr Val Asp Pro Thr Ser Ser Asp Phe Ser Thr Pro 
            265                 270                 275         


Cys Leu Met Tyr Glu Lys Phe Val Asn Ile Thr Val Lys Ser Leu Tyr 
        280                 285                 290             


Pro Asn Pro Thr Val Gln Leu Arg Lys Ala Leu Asn Thr Asn Leu Asp 
    295                 300                 305                 


Phe Leu Phe Gln Gly Val Ala Ala Gly Cys Thr Gln Val Phe Pro Tyr 
310                 315                 320                 325 


Gly Arg Asp 
            


<210>  31
<211>  1113
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variante W24F obtenida a partir de la variante JaWa


<220>
<221>  CDS
<222>  (1)..(1113)

<220>
<221>  mat_peptide
<222>  (130)..(1113)

<400>  31
atg aaa tat ttt ccc ctg ttc cca acc ttg gtc tac gca gtg ggg gtc         48
Met Lys Tyr Phe Pro Leu Phe Pro Thr Leu Val Tyr Ala Val Gly Val           
            -40                 -35                 -30                   

gtt gct ttt cct gac tac gcc tca ttg gcc ggc ctc agc cag cag gaa         96
Val Ala Phe Pro Asp Tyr Ala Ser Leu Ala Gly Leu Ser Gln Gln Glu           
        -25                 -20                 -15                       

ttg gac gct ata atc cca aca ctc gag gcc cga gag cca gga tta cct        144
Leu Asp Ala Ile Ile Pro Thr Leu Glu Ala Arg Glu Pro Gly Leu Pro           
    -10                 -5              -1  1               5             

cct ggt cct ctc gag aat agc tct gca aag ttg gtg aac gac gag gct        192
Pro Gly Pro Leu Glu Asn Ser Ser Ala Lys Leu Val Asn Asp Glu Ala           
                10                  15                  20                

cac cca ttt aag ccg ctt cga cct ggc gat att cgt gga cct tgc cct        240
His Pro Phe Lys Pro Leu Arg Pro Gly Asp Ile Arg Gly Pro Cys Pro           
            25                  30                  35                    

ggt ctc aat act ctg gca tct cac ggg tac ctc ccg aga aat ggc gtt        288
Gly Leu Asn Thr Leu Ala Ser His Gly Tyr Leu Pro Arg Asn Gly Val           
        40                  45                  50                        

gca acc ccg gcg caa ata ata aac gcg gtt cag gaa gga ttc aat ttc        336
Ala Thr Pro Ala Gln Ile Ile Asn Ala Val Gln Glu Gly Phe Asn Phe           
    55                  60                  65                            

gac aat caa gcc gca atc ttc gcc aca tat gcg gcc cac ctt gtg gac        384
Asp Asn Gln Ala Ala Ile Phe Ala Thr Tyr Ala Ala His Leu Val Asp           
70                  75                  80                  85            

ggc aat ctc att acg gac ttg ctg agc atc gga cgc aag acg cgg ctc        432
Gly Asn Leu Ile Thr Asp Leu Leu Ser Ile Gly Arg Lys Thr Arg Leu           
                90                  95                  100               

act ggg cct gat cca cca ccc ccc gct tcc gtt ggt gga ctc aat gag        480
Thr Gly Pro Asp Pro Pro Pro Pro Ala Ser Val Gly Gly Leu Asn Glu           
            105                 110                 115                   

cat ggc acc ttc gaa ggc gac gcc agt atg acc cga ggt gac gca ttc        528
His Gly Thr Phe Glu Gly Asp Ala Ser Met Thr Arg Gly Asp Ala Phe           
        120                 125                 130                       

ttt ggc aac aac cac gat ttc aat gag acg ctc ttc gaa cag ttg gtt        576
Phe Gly Asn Asn His Asp Phe Asn Glu Thr Leu Phe Glu Gln Leu Val           
    135                 140                 145                           

gac tac agc aac cga ttt gga gga gga aaa tac aat ctt acc gtc gcg        624
Asp Tyr Ser Asn Arg Phe Gly Gly Gly Lys Tyr Asn Leu Thr Val Ala           
150                 155                 160                 165           

ggg gag ctc cgt ttc aag cgc att caa gac tcc att gcg acc aac ccc        672
Gly Glu Leu Arg Phe Lys Arg Ile Gln Asp Ser Ile Ala Thr Asn Pro           
                170                 175                 180               

aat ttc tcc ttt gtt gac ttt agg ttc ttt act gct tac ggc gag acc        720
Asn Phe Ser Phe Val Asp Phe Arg Phe Phe Thr Ala Tyr Gly Glu Thr           
            185                 190                 195                   

acc ttc ccc gcg aat ctt ttt gtg gat ggg cgc agg gac gac ggc cag        768
Thr Phe Pro Ala Asn Leu Phe Val Asp Gly Arg Arg Asp Asp Gly Gln           
        200                 205                 210                       

cta gat atg gat gct gca cgg agt ttt ttc caa ttc agc cgt atg cct        816
Leu Asp Met Asp Ala Ala Arg Ser Phe Phe Gln Phe Ser Arg Met Pro           
    215                 220                 225                           

gac gat ttc ttc cgc gca ccc agc ccg aga agt gac aca gga gtc gag        864
Asp Asp Phe Phe Arg Ala Pro Ser Pro Arg Ser Asp Thr Gly Val Glu           
230                 235                 240                 245           

gta gtt gta cag gct cat cct atg cag ccc gga aaa aat gtc ggc aag        912
Val Val Val Gln Ala His Pro Met Gln Pro Gly Lys Asn Val Gly Lys           
                250                 255                 260               

atc aac agc tac acc gtc gac cca aca tcc tct gac ttt tcc acc ccc        960
Ile Asn Ser Tyr Thr Val Asp Pro Thr Ser Ser Asp Phe Ser Thr Pro           
            265                 270                 275                   

tgc ttg atg tac gag aaa ttc gtc aac ata acg gtc aag tca ctc tac       1008
Cys Leu Met Tyr Glu Lys Phe Val Asn Ile Thr Val Lys Ser Leu Tyr           
        280                 285                 290                       

ccg aat ccg acg gtg cag ctt cgc aaa gcc ctt aat acg aat ctc gat       1056
Pro Asn Pro Thr Val Gln Leu Arg Lys Ala Leu Asn Thr Asn Leu Asp           
    295                 300                 305                           

ttc tta ttc cag gga gtc gcc gct gga tgt acc cag gtc ttc cca tac       1104
Phe Leu Phe Gln Gly Val Ala Ala Gly Cys Thr Gln Val Phe Pro Tyr           
310                 315                 320                 325           

ggg cga gat                                                           1113
Gly Arg Asp                                                               
                                                                          


<210>  32
<211>  371
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  32

Met Lys Tyr Phe Pro Leu Phe Pro Thr Leu Val Tyr Ala Val Gly Val 
            -40                 -35                 -30         


Val Ala Phe Pro Asp Tyr Ala Ser Leu Ala Gly Leu Ser Gln Gln Glu 
        -25                 -20                 -15             


Leu Asp Ala Ile Ile Pro Thr Leu Glu Ala Arg Glu Pro Gly Leu Pro 
    -10                 -5              -1  1               5   


Pro Gly Pro Leu Glu Asn Ser Ser Ala Lys Leu Val Asn Asp Glu Ala 
                10                  15                  20      


His Pro Phe Lys Pro Leu Arg Pro Gly Asp Ile Arg Gly Pro Cys Pro 
            25                  30                  35          


Gly Leu Asn Thr Leu Ala Ser His Gly Tyr Leu Pro Arg Asn Gly Val 
        40                  45                  50              


Ala Thr Pro Ala Gln Ile Ile Asn Ala Val Gln Glu Gly Phe Asn Phe 
    55                  60                  65                  


Asp Asn Gln Ala Ala Ile Phe Ala Thr Tyr Ala Ala His Leu Val Asp 
70                  75                  80                  85  


Gly Asn Leu Ile Thr Asp Leu Leu Ser Ile Gly Arg Lys Thr Arg Leu 
                90                  95                  100     


Thr Gly Pro Asp Pro Pro Pro Pro Ala Ser Val Gly Gly Leu Asn Glu 
            105                 110                 115         


His Gly Thr Phe Glu Gly Asp Ala Ser Met Thr Arg Gly Asp Ala Phe 
        120                 125                 130             


Phe Gly Asn Asn His Asp Phe Asn Glu Thr Leu Phe Glu Gln Leu Val 
    135                 140                 145                 


Asp Tyr Ser Asn Arg Phe Gly Gly Gly Lys Tyr Asn Leu Thr Val Ala 
150                 155                 160                 165 


Gly Glu Leu Arg Phe Lys Arg Ile Gln Asp Ser Ile Ala Thr Asn Pro 
                170                 175                 180     


Asn Phe Ser Phe Val Asp Phe Arg Phe Phe Thr Ala Tyr Gly Glu Thr 
            185                 190                 195         


Thr Phe Pro Ala Asn Leu Phe Val Asp Gly Arg Arg Asp Asp Gly Gln 
        200                 205                 210             


Leu Asp Met Asp Ala Ala Arg Ser Phe Phe Gln Phe Ser Arg Met Pro 
    215                 220                 225                 


Asp Asp Phe Phe Arg Ala Pro Ser Pro Arg Ser Asp Thr Gly Val Glu 
230                 235                 240                 245 


Val Val Val Gln Ala His Pro Met Gln Pro Gly Lys Asn Val Gly Lys 
                250                 255                 260     


Ile Asn Ser Tyr Thr Val Asp Pro Thr Ser Ser Asp Phe Ser Thr Pro 
            265                 270                 275         


Cys Leu Met Tyr Glu Lys Phe Val Asn Ile Thr Val Lys Ser Leu Tyr 
        280                 285                 290             


Pro Asn Pro Thr Val Gln Leu Arg Lys Ala Leu Asn Thr Asn Leu Asp 
    295                 300                 305                 


Phe Leu Phe Gln Gly Val Ala Ala Gly Cys Thr Gln Val Phe Pro Tyr 
310                 315                 320                 325 


Gly Arg Asp 
            


<210>  33
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cebador RMLN

<400>  33
cctctatact ttaacgtcaa gg                                                22


<210>  34
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cebador RMLC

<400>  34
gggagggcgt gaatgtaagc                                                   20


<210>  35
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cebador F24FOR

<400>  35
ctcacccatt taagccgctt cgacctggcg atattcgtgg ac                          42


<210>  36
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cebador F24REV

<400>  36
gtccacgaat atcgccaggt cgaagcggct taaatgggtg ag                          42


<210>  37
<211>  984
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variante SoLo sin pptido seal


<220>
<221>  CDS
<222>  (1)..(984)

<400>  37
gag cca gga tta cct cct ggt cct ctc gag aat agc tct gca aag ttg         48
Glu Pro Gly Leu Pro Pro Gly Pro Leu Glu Asn Ser Ser Ala Lys Leu           
1               5                   10                  15                

gtg aac gac gag gct cac cca tgg aag ccg ctt cga cct ggc gat att         96
Val Asn Asp Glu Ala His Pro Trp Lys Pro Leu Arg Pro Gly Asp Ile           
            20                  25                  30                    

cgt gga cct tgc cct ggt ctc aat act ctg gca tct cac ggg tac ctc        144
Arg Gly Pro Cys Pro Gly Leu Asn Thr Leu Ala Ser His Gly Tyr Leu           
        35                  40                  45                        

ccg aga aat ggc gtt gca acc ccg gcg caa ata ata aac gcg gtt cag        192
Pro Arg Asn Gly Val Ala Thr Pro Ala Gln Ile Ile Asn Ala Val Gln           
    50                  55                  60                            

gaa gga ttc aat ttc gac aat caa gcc gca atc ttc gcc aca tat gcg        240
Glu Gly Phe Asn Phe Asp Asn Gln Ala Ala Ile Phe Ala Thr Tyr Ala           
65                  70                  75                  80            

gcc cac ctt gtg gac ggc aat ctc att acg gac ttg ctg agc atc gga        288
Ala His Leu Val Asp Gly Asn Leu Ile Thr Asp Leu Leu Ser Ile Gly           
                85                  90                  95                

cgc aag acg cgg ctc act ggg cct gat cca cca ccc ccc gct tcc gtt        336
Arg Lys Thr Arg Leu Thr Gly Pro Asp Pro Pro Pro Pro Ala Ser Val           
            100                 105                 110                   

ggt gga ctc aat gag cat ggc acc ttc gaa ggc gac gcc agt atg acc        384
Gly Gly Leu Asn Glu His Gly Thr Phe Glu Gly Asp Ala Ser Met Thr           
        115                 120                 125                       

cga ggt gac gca ttc ttt ggc aac aac cac gat ttc aat gag acg ctc        432
Arg Gly Asp Ala Phe Phe Gly Asn Asn His Asp Phe Asn Glu Thr Leu           
    130                 135                 140                           

ttc gaa cag ttg gtt gac tac agc aac cga ttt gga gga gga aaa tac        480
Phe Glu Gln Leu Val Asp Tyr Ser Asn Arg Phe Gly Gly Gly Lys Tyr           
145                 150                 155                 160           

aat ctt acc gtc gcg ggg gag ctc cgt ttc aag cgc att caa gac tcc        528
Asn Leu Thr Val Ala Gly Glu Leu Arg Phe Lys Arg Ile Gln Asp Ser           
                165                 170                 175               

att gcg acc aac ccc aat ttc tcc ttt gtt gac ttt agg ttc tct act        576
Ile Ala Thr Asn Pro Asn Phe Ser Phe Val Asp Phe Arg Phe Ser Thr           
            180                 185                 190                   

gct tac ggc gag acc acc ttc ccc gcg aat ctt ttt gtg gat ggg cgc        624
Ala Tyr Gly Glu Thr Thr Phe Pro Ala Asn Leu Phe Val Asp Gly Arg           
        195                 200                 205                       

agg gac gac ggc cag cta gat atg gat gct gca cgg agt ttt ttc caa        672
Arg Asp Asp Gly Gln Leu Asp Met Asp Ala Ala Arg Ser Phe Phe Gln           
    210                 215                 220                           

ttc agc cgt atg cct gac gat ttc ttc cgc gca ccc agc ccg aga agt        720
Phe Ser Arg Met Pro Asp Asp Phe Phe Arg Ala Pro Ser Pro Arg Ser           
225                 230                 235                 240           

gac aca gga gtc gag gta gtt gta cag gct cat cct atg cag ccc gga        768
Asp Thr Gly Val Glu Val Val Val Gln Ala His Pro Met Gln Pro Gly           
                245                 250                 255               

aaa aat gtc ggc aag atc aac agc tac acc gtc gac cca aca tcc tct        816
Lys Asn Val Gly Lys Ile Asn Ser Tyr Thr Val Asp Pro Thr Ser Ser           
            260                 265                 270                   

gac ttt tcc acc ccc tgc ttg atg tac gag aaa ttc gtc aac ata acg        864
Asp Phe Ser Thr Pro Cys Leu Met Tyr Glu Lys Phe Val Asn Ile Thr           
        275                 280                 285                       

gtc aag tca ctc tac ccg aat ccg acg gtg cag ctt cgc aaa gcc ctt        912
Val Lys Ser Leu Tyr Pro Asn Pro Thr Val Gln Leu Arg Lys Ala Leu           
    290                 295                 300                           

aat acg aat ctc gat ttc tta ttc cag gga gtc gcc gct gga tgt acc        960
Asn Thr Asn Leu Asp Phe Leu Phe Gln Gly Val Ala Ala Gly Cys Thr           
305                 310                 315                 320           

cag gtc ttc cca tac ggg cga gat                                        984
Gln Val Phe Pro Tyr Gly Arg Asp                                           
                325                                                       


<210>  38
<211>  328
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  38

Glu Pro Gly Leu Pro Pro Gly Pro Leu Glu Asn Ser Ser Ala Lys Leu 
1               5                   10                  15      


Val Asn Asp Glu Ala His Pro Trp Lys Pro Leu Arg Pro Gly Asp Ile 
            20                  25                  30          


Arg Gly Pro Cys Pro Gly Leu Asn Thr Leu Ala Ser His Gly Tyr Leu 
        35                  40                  45              


Pro Arg Asn Gly Val Ala Thr Pro Ala Gln Ile Ile Asn Ala Val Gln 
    50                  55                  60                  


Glu Gly Phe Asn Phe Asp Asn Gln Ala Ala Ile Phe Ala Thr Tyr Ala 
65                  70                  75                  80  


Ala His Leu Val Asp Gly Asn Leu Ile Thr Asp Leu Leu Ser Ile Gly 
                85                  90                  95      


Arg Lys Thr Arg Leu Thr Gly Pro Asp Pro Pro Pro Pro Ala Ser Val 
            100                 105                 110         


Gly Gly Leu Asn Glu His Gly Thr Phe Glu Gly Asp Ala Ser Met Thr 
        115                 120                 125             


Arg Gly Asp Ala Phe Phe Gly Asn Asn His Asp Phe Asn Glu Thr Leu 
    130                 135                 140                 


Phe Glu Gln Leu Val Asp Tyr Ser Asn Arg Phe Gly Gly Gly Lys Tyr 
145                 150                 155                 160 


Asn Leu Thr Val Ala Gly Glu Leu Arg Phe Lys Arg Ile Gln Asp Ser 
                165                 170                 175     


Ile Ala Thr Asn Pro Asn Phe Ser Phe Val Asp Phe Arg Phe Ser Thr 
            180                 185                 190         


Ala Tyr Gly Glu Thr Thr Phe Pro Ala Asn Leu Phe Val Asp Gly Arg 
        195                 200                 205             


Arg Asp Asp Gly Gln Leu Asp Met Asp Ala Ala Arg Ser Phe Phe Gln 
    210                 215                 220                 


Phe Ser Arg Met Pro Asp Asp Phe Phe Arg Ala Pro Ser Pro Arg Ser 
225                 230                 235                 240 


Asp Thr Gly Val Glu Val Val Val Gln Ala His Pro Met Gln Pro Gly 
                245                 250                 255     


Lys Asn Val Gly Lys Ile Asn Ser Tyr Thr Val Asp Pro Thr Ser Ser 
            260                 265                 270         


Asp Phe Ser Thr Pro Cys Leu Met Tyr Glu Lys Phe Val Asn Ile Thr 
        275                 280                 285             


Val Lys Ser Leu Tyr Pro Asn Pro Thr Val Gln Leu Arg Lys Ala Leu 
    290                 295                 300                 


Asn Thr Asn Leu Asp Phe Leu Phe Gln Gly Val Ala Ala Gly Cys Thr 
305                 310                 315                 320 


Gln Val Phe Pro Tyr Gly Arg Asp 
                325             


<210>  39
<211>  1113
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variante SoLo con peptido seal silvestre


<220>
<221>  CDS
<222>  (1)..(1113)

<220>
<221>  mat_peptide
<222>  (130)..(1113)

<400>  39
atg aaa tat ttt ccc ctg ttc cca acc ttg gtc ttc gca gcg agg gtc         48
Met Lys Tyr Phe Pro Leu Phe Pro Thr Leu Val Phe Ala Ala Arg Val           
            -40                 -35                 -30                   

gtt gct ttt cct gcc tac gcc tca ttg gcc ggc ctc agc cag cag gaa         96
Val Ala Phe Pro Ala Tyr Ala Ser Leu Ala Gly Leu Ser Gln Gln Glu           
        -25                 -20                 -15                       

ttg gac gct ata atc cca aca ctc gag gcc cga gag cca gga tta cct        144
Leu Asp Ala Ile Ile Pro Thr Leu Glu Ala Arg Glu Pro Gly Leu Pro           
    -10                 -5              -1  1               5             

cct ggt cct ctc gag aat agc tct gca aag ttg gtg aac gac gag gct        192
Pro Gly Pro Leu Glu Asn Ser Ser Ala Lys Leu Val Asn Asp Glu Ala           
                10                  15                  20                

cac cca tgg aag ccg ctt cga cct ggc gat att cgt gga cct tgc cct        240
His Pro Trp Lys Pro Leu Arg Pro Gly Asp Ile Arg Gly Pro Cys Pro           
            25                  30                  35                    

ggt ctc aat act ctg gca tct cac ggg tac ctc ccg aga aat ggc gtt        288
Gly Leu Asn Thr Leu Ala Ser His Gly Tyr Leu Pro Arg Asn Gly Val           
        40                  45                  50                        

gca acc ccg gcg caa ata ata aac gcg gtt cag gaa gga ttc aat ttc        336
Ala Thr Pro Ala Gln Ile Ile Asn Ala Val Gln Glu Gly Phe Asn Phe           
    55                  60                  65                            

gac aat caa gcc gca atc ttc gcc aca tat gcg gcc cac ctt gtg gac        384
Asp Asn Gln Ala Ala Ile Phe Ala Thr Tyr Ala Ala His Leu Val Asp           
70                  75                  80                  85            

ggc aat ctc att acg gac ttg ctg agc atc gga cgc aag acg cgg ctc        432
Gly Asn Leu Ile Thr Asp Leu Leu Ser Ile Gly Arg Lys Thr Arg Leu           
                90                  95                  100               

act ggg cct gat cca cca ccc ccc gct tcc gtt ggt gga ctc aat gag        480
Thr Gly Pro Asp Pro Pro Pro Pro Ala Ser Val Gly Gly Leu Asn Glu           
            105                 110                 115                   

cat ggc acc ttc gaa ggc gac gcc agt atg acc cga ggt gac gca ttc        528
His Gly Thr Phe Glu Gly Asp Ala Ser Met Thr Arg Gly Asp Ala Phe           
        120                 125                 130                       

ttt ggc aac aac cac gat ttc aat gag acg ctc ttc gaa cag ttg gtt        576
Phe Gly Asn Asn His Asp Phe Asn Glu Thr Leu Phe Glu Gln Leu Val           
    135                 140                 145                           

gac tac agc aac cga ttt gga gga gga aaa tac aat ctt acc gtc gcg        624
Asp Tyr Ser Asn Arg Phe Gly Gly Gly Lys Tyr Asn Leu Thr Val Ala           
150                 155                 160                 165           

ggg gag ctc cgt ttc aag cgc att caa gac tcc att gcg acc aac ccc        672
Gly Glu Leu Arg Phe Lys Arg Ile Gln Asp Ser Ile Ala Thr Asn Pro           
                170                 175                 180               

aat ttc tcc ttt gtt gac ttt agg ttc tct act gct tac ggc gag acc        720
Asn Phe Ser Phe Val Asp Phe Arg Phe Ser Thr Ala Tyr Gly Glu Thr           
            185                 190                 195                   

acc ttc ccc gcg aat ctt ttt gtg gat ggg cgc agg gac gac ggc cag        768
Thr Phe Pro Ala Asn Leu Phe Val Asp Gly Arg Arg Asp Asp Gly Gln           
        200                 205                 210                       

cta gat atg gat gct gca cgg agt ttt ttc caa ttc agc cgt atg cct        816
Leu Asp Met Asp Ala Ala Arg Ser Phe Phe Gln Phe Ser Arg Met Pro           
    215                 220                 225                           

gac gat ttc ttc cgc gca ccc agc ccg aga agt gac aca gga gtc gag        864
Asp Asp Phe Phe Arg Ala Pro Ser Pro Arg Ser Asp Thr Gly Val Glu           
230                 235                 240                 245           

gta gtt gta cag gct cat cct atg cag ccc gga aaa aat gtc ggc aag        912
Val Val Val Gln Ala His Pro Met Gln Pro Gly Lys Asn Val Gly Lys           
                250                 255                 260               

atc aac agc tac acc gtc gac cca aca tcc tct gac ttt tcc acc ccc        960
Ile Asn Ser Tyr Thr Val Asp Pro Thr Ser Ser Asp Phe Ser Thr Pro           
            265                 270                 275                   

tgc ttg atg tac gag aaa ttc gtc aac ata acg gtc aag tca ctc tac       1008
Cys Leu Met Tyr Glu Lys Phe Val Asn Ile Thr Val Lys Ser Leu Tyr           
        280                 285                 290                       

ccg aat ccg acg gtg cag ctt cgc aaa gcc ctt aat acg aat ctc gat       1056
Pro Asn Pro Thr Val Gln Leu Arg Lys Ala Leu Asn Thr Asn Leu Asp           
    295                 300                 305                           

ttc tta ttc cag gga gtc gcc gct gga tgt acc cag gtc ttc cca tac       1104
Phe Leu Phe Gln Gly Val Ala Ala Gly Cys Thr Gln Val Phe Pro Tyr           
310                 315                 320                 325           

ggg cga gat                                                           1113
Gly Arg Asp                                                               
                                                                          


<210>  40
<211>  371
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  40

Met Lys Tyr Phe Pro Leu Phe Pro Thr Leu Val Phe Ala Ala Arg Val 
            -40                 -35                 -30         


Val Ala Phe Pro Ala Tyr Ala Ser Leu Ala Gly Leu Ser Gln Gln Glu 
        -25                 -20                 -15             


Leu Asp Ala Ile Ile Pro Thr Leu Glu Ala Arg Glu Pro Gly Leu Pro 
    -10                 -5              -1  1               5   


Pro Gly Pro Leu Glu Asn Ser Ser Ala Lys Leu Val Asn Asp Glu Ala 
                10                  15                  20      


His Pro Trp Lys Pro Leu Arg Pro Gly Asp Ile Arg Gly Pro Cys Pro 
            25                  30                  35          


Gly Leu Asn Thr Leu Ala Ser His Gly Tyr Leu Pro Arg Asn Gly Val 
        40                  45                  50              


Ala Thr Pro Ala Gln Ile Ile Asn Ala Val Gln Glu Gly Phe Asn Phe 
    55                  60                  65                  


Asp Asn Gln Ala Ala Ile Phe Ala Thr Tyr Ala Ala His Leu Val Asp 
70                  75                  80                  85  


Gly Asn Leu Ile Thr Asp Leu Leu Ser Ile Gly Arg Lys Thr Arg Leu 
                90                  95                  100     


Thr Gly Pro Asp Pro Pro Pro Pro Ala Ser Val Gly Gly Leu Asn Glu 
            105                 110                 115         


His Gly Thr Phe Glu Gly Asp Ala Ser Met Thr Arg Gly Asp Ala Phe 
        120                 125                 130             


Phe Gly Asn Asn His Asp Phe Asn Glu Thr Leu Phe Glu Gln Leu Val 
    135                 140                 145                 


Asp Tyr Ser Asn Arg Phe Gly Gly Gly Lys Tyr Asn Leu Thr Val Ala 
150                 155                 160                 165 


Gly Glu Leu Arg Phe Lys Arg Ile Gln Asp Ser Ile Ala Thr Asn Pro 
                170                 175                 180     


Asn Phe Ser Phe Val Asp Phe Arg Phe Ser Thr Ala Tyr Gly Glu Thr 
            185                 190                 195         


Thr Phe Pro Ala Asn Leu Phe Val Asp Gly Arg Arg Asp Asp Gly Gln 
        200                 205                 210             


Leu Asp Met Asp Ala Ala Arg Ser Phe Phe Gln Phe Ser Arg Met Pro 
    215                 220                 225                 


Asp Asp Phe Phe Arg Ala Pro Ser Pro Arg Ser Asp Thr Gly Val Glu 
230                 235                 240                 245 


Val Val Val Gln Ala His Pro Met Gln Pro Gly Lys Asn Val Gly Lys 
                250                 255                 260     


Ile Asn Ser Tyr Thr Val Asp Pro Thr Ser Ser Asp Phe Ser Thr Pro 
            265                 270                 275         


Cys Leu Met Tyr Glu Lys Phe Val Asn Ile Thr Val Lys Ser Leu Tyr 
        280                 285                 290             


Pro Asn Pro Thr Val Gln Leu Arg Lys Ala Leu Asn Thr Asn Leu Asp 
    295                 300                 305                 


Phe Leu Phe Gln Gly Val Ala Ala Gly Cys Thr Gln Val Phe Pro Tyr 
310                 315                 320                 325 


Gly Arg Asp 
            


<210>  41
<211>  1113
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variante SoLo con pptido seal modificado


<220>
<221>  CDS
<222>  (1)..(1113)

<220>
<221>  mat_peptide
<222>  (130)..(1113)

<400>  41
atg aaa tat ttt ccc ctg ttc cca acc ttg gtc tac gca gtg ggg gtc         48
Met Lys Tyr Phe Pro Leu Phe Pro Thr Leu Val Tyr Ala Val Gly Val           
            -40                 -35                 -30                   

gtt gct ttt cct gac tac gcc tca ttg gcc ggc ctc agc cag cag gaa         96
Val Ala Phe Pro Asp Tyr Ala Ser Leu Ala Gly Leu Ser Gln Gln Glu           
        -25                 -20                 -15                       

ttg gac gct ata atc cca aca ctc gag gcc cga gag cca gga tta cct        144
Leu Asp Ala Ile Ile Pro Thr Leu Glu Ala Arg Glu Pro Gly Leu Pro           
    -10                 -5              -1  1               5             

cct ggt cct ctc gag aat agc tct gca aag ttg gtg aac gac gag gct        192
Pro Gly Pro Leu Glu Asn Ser Ser Ala Lys Leu Val Asn Asp Glu Ala           
                10                  15                  20                

cac cca tgg aag ccg ctt cga cct ggc gat att cgt gga cct tgc cct        240
His Pro Trp Lys Pro Leu Arg Pro Gly Asp Ile Arg Gly Pro Cys Pro           
            25                  30                  35                    

ggt ctc aat act ctg gca tct cac ggg tac ctc ccg aga aat ggc gtt        288
Gly Leu Asn Thr Leu Ala Ser His Gly Tyr Leu Pro Arg Asn Gly Val           
        40                  45                  50                        

gca acc ccg gcg caa ata ata aac gcg gtt cag gaa gga ttc aat ttc        336
Ala Thr Pro Ala Gln Ile Ile Asn Ala Val Gln Glu Gly Phe Asn Phe           
    55                  60                  65                            

gac aat caa gcc gca atc ttc gcc aca tat gcg gcc cac ctt gtg gac        384
Asp Asn Gln Ala Ala Ile Phe Ala Thr Tyr Ala Ala His Leu Val Asp           
70                  75                  80                  85            

ggc aat ctc att acg gac ttg ctg agc atc gga cgc aag acg cgg ctc        432
Gly Asn Leu Ile Thr Asp Leu Leu Ser Ile Gly Arg Lys Thr Arg Leu           
                90                  95                  100               

act ggg cct gat cca cca ccc ccc gct tcc gtt ggt gga ctc aat gag        480
Thr Gly Pro Asp Pro Pro Pro Pro Ala Ser Val Gly Gly Leu Asn Glu           
            105                 110                 115                   

cat ggc acc ttc gaa ggc gac gcc agt atg acc cga ggt gac gca ttc        528
His Gly Thr Phe Glu Gly Asp Ala Ser Met Thr Arg Gly Asp Ala Phe           
        120                 125                 130                       

ttt ggc aac aac cac gat ttc aat gag acg ctc ttc gaa cag ttg gtt        576
Phe Gly Asn Asn His Asp Phe Asn Glu Thr Leu Phe Glu Gln Leu Val           
    135                 140                 145                           

gac tac agc aac cga ttt gga gga gga aaa tac aat ctt acc gtc gcg        624
Asp Tyr Ser Asn Arg Phe Gly Gly Gly Lys Tyr Asn Leu Thr Val Ala           
150                 155                 160                 165           

ggg gag ctc cgt ttc aag cgc att caa gac tcc att gcg acc aac ccc        672
Gly Glu Leu Arg Phe Lys Arg Ile Gln Asp Ser Ile Ala Thr Asn Pro           
                170                 175                 180               

aat ttc tcc ttt gtt gac ttt agg ttc tct act gct tac ggc gag acc        720
Asn Phe Ser Phe Val Asp Phe Arg Phe Ser Thr Ala Tyr Gly Glu Thr           
            185                 190                 195                   

acc ttc ccc gcg aat ctt ttt gtg gat ggg cgc agg gac gac ggc cag        768
Thr Phe Pro Ala Asn Leu Phe Val Asp Gly Arg Arg Asp Asp Gly Gln           
        200                 205                 210                       

cta gat atg gat gct gca cgg agt ttt ttc caa ttc agc cgt atg cct        816
Leu Asp Met Asp Ala Ala Arg Ser Phe Phe Gln Phe Ser Arg Met Pro           
    215                 220                 225                           

gac gat ttc ttc cgc gca ccc agc ccg aga agt gac aca gga gtc gag        864
Asp Asp Phe Phe Arg Ala Pro Ser Pro Arg Ser Asp Thr Gly Val Glu           
230                 235                 240                 245           

gta gtt gta cag gct cat cct atg cag ccc gga aaa aat gtc ggc aag        912
Val Val Val Gln Ala His Pro Met Gln Pro Gly Lys Asn Val Gly Lys           
                250                 255                 260               

atc aac agc tac acc gtc gac cca aca tcc tct gac ttt tcc acc ccc        960
Ile Asn Ser Tyr Thr Val Asp Pro Thr Ser Ser Asp Phe Ser Thr Pro           
            265                 270                 275                   

tgc ttg atg tac gag aaa ttc gtc aac ata acg gtc aag tca ctc tac       1008
Cys Leu Met Tyr Glu Lys Phe Val Asn Ile Thr Val Lys Ser Leu Tyr           
        280                 285                 290                       

ccg aat ccg acg gtg cag ctt cgc aaa gcc ctt aat acg aat ctc gat       1056
Pro Asn Pro Thr Val Gln Leu Arg Lys Ala Leu Asn Thr Asn Leu Asp           
    295                 300                 305                           

ttc tta ttc cag gga gtc gcc gct gga tgt acc cag gtc ttc cca tac       1104
Phe Leu Phe Gln Gly Val Ala Ala Gly Cys Thr Gln Val Phe Pro Tyr           
310                 315                 320                 325           

ggg cga gat                                                           1113
Gly Arg Asp                                                               
                                                                          


<210>  42
<211>  371
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  42

Met Lys Tyr Phe Pro Leu Phe Pro Thr Leu Val Tyr Ala Val Gly Val 
            -40                 -35                 -30         


Val Ala Phe Pro Asp Tyr Ala Ser Leu Ala Gly Leu Ser Gln Gln Glu 
        -25                 -20                 -15             


Leu Asp Ala Ile Ile Pro Thr Leu Glu Ala Arg Glu Pro Gly Leu Pro 
    -10                 -5              -1  1               5   


Pro Gly Pro Leu Glu Asn Ser Ser Ala Lys Leu Val Asn Asp Glu Ala 
                10                  15                  20      


His Pro Trp Lys Pro Leu Arg Pro Gly Asp Ile Arg Gly Pro Cys Pro 
            25                  30                  35          


Gly Leu Asn Thr Leu Ala Ser His Gly Tyr Leu Pro Arg Asn Gly Val 
        40                  45                  50              


Ala Thr Pro Ala Gln Ile Ile Asn Ala Val Gln Glu Gly Phe Asn Phe 
    55                  60                  65                  


Asp Asn Gln Ala Ala Ile Phe Ala Thr Tyr Ala Ala His Leu Val Asp 
70                  75                  80                  85  


Gly Asn Leu Ile Thr Asp Leu Leu Ser Ile Gly Arg Lys Thr Arg Leu 
                90                  95                  100     


Thr Gly Pro Asp Pro Pro Pro Pro Ala Ser Val Gly Gly Leu Asn Glu 
            105                 110                 115         


His Gly Thr Phe Glu Gly Asp Ala Ser Met Thr Arg Gly Asp Ala Phe 
        120                 125                 130             


Phe Gly Asn Asn His Asp Phe Asn Glu Thr Leu Phe Glu Gln Leu Val 
    135                 140                 145                 


Asp Tyr Ser Asn Arg Phe Gly Gly Gly Lys Tyr Asn Leu Thr Val Ala 
150                 155                 160                 165 


Gly Glu Leu Arg Phe Lys Arg Ile Gln Asp Ser Ile Ala Thr Asn Pro 
                170                 175                 180     


Asn Phe Ser Phe Val Asp Phe Arg Phe Ser Thr Ala Tyr Gly Glu Thr 
            185                 190                 195         


Thr Phe Pro Ala Asn Leu Phe Val Asp Gly Arg Arg Asp Asp Gly Gln 
        200                 205                 210             


Leu Asp Met Asp Ala Ala Arg Ser Phe Phe Gln Phe Ser Arg Met Pro 
    215                 220                 225                 


Asp Asp Phe Phe Arg Ala Pro Ser Pro Arg Ser Asp Thr Gly Val Glu 
230                 235                 240                 245 


Val Val Val Gln Ala His Pro Met Gln Pro Gly Lys Asn Val Gly Lys 
                250                 255                 260     


Ile Asn Ser Tyr Thr Val Asp Pro Thr Ser Ser Asp Phe Ser Thr Pro 
            265                 270                 275         


Cys Leu Met Tyr Glu Lys Phe Val Asn Ile Thr Val Lys Ser Leu Tyr 
        280                 285                 290             


Pro Asn Pro Thr Val Gln Leu Arg Lys Ala Leu Asn Thr Asn Leu Asp 
    295                 300                 305                 


Phe Leu Phe Gln Gly Val Ala Ala Gly Cys Thr Gln Val Phe Pro Tyr 
310                 315                 320                 325 


Gly Arg Asp 
            


<210>  43
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cebador MJaWa Fw

<400>  43
gcgcattcaa gactccattg                                                   20


<210>  44
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cebador MJaWa Rev

<400>  44
gatcttgccg acattttttc c                                                 21


<210>  45
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cebador HFJaWa Fw

<400>  45
caggctcatc ctatgcagcc c                                                 21


<210>  46
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cebador HFJaWa Rev

<400>  46
caaaggagaa attggggttg gtcg                                              24


<210>  47
<211>  61
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cebador VHG R

<400>  47
gcaagtccgt aatgagattg ccgtccacaa ggtgggccgc atatgtggcc dbgattgcgg       60

c                                                                       61


<210>  48
<211>  61
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cebador NDT R


<220>
<221>  misc_feature
<222>  (52)..(52)
<223>  n is a, c, g, or t

<400>  48
gcaagtccgt aatgagattg ccgtccacaa ggtgggccgc atatgtggca hngattgcgg       60

c                                                                       61


<210>  49
<211>  61
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cebador TGG R

<400>  49
gcaagtccgt aatgagattg ccgtccacaa ggtgggccgc atatgtggcc cagattgcgg       60

c                                                                       61


<210>  50
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cebador HF F

<400>  50
gcggcccacc ttgtggacgg caatctcatt acggacttgc                             40


<210>  51
<211>  61
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cebador S191 VHG R

<400>  51
cccatccaca aaaagattcg cggggaaggt ggtctcgccg taagcagtcd bgaacctaaa       60

g                                                                       61


<210>  52
<211>  61
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cebador NDT R


<220>
<221>  misc_feature
<222>  (51)..(51)
<223>  n is a, c, g, or t

<400>  52
cccatccaca aaaagattcg cggggaaggt ggtctcgccg taagcagtah ngaacctaaa       60

g                                                                       61


<210>  53
<211>  61
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cebador S191 TGG R

<400>  53
cccatccaca aaaagattcg cggggaaggt ggtctcgccg taagcagtcc agaacctaaa       60

g                                                                       61


<210>  54
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cebador HF F-RMLC

<400>  54
cggcgagacc accttccccg cgaatctttt tgtggatggg                             40


<210>  55
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cebador F69 R


<220>
<221>  misc_feature
<222>  (23)..(24)
<223>  n is a, c, g, or t

<400>  55
gaagattgcg gcttgattgt cmnnattgaa tc                                     32


<210>  56
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cebador F69 F


<220>
<221>  misc_feature
<222>  (23)..(24)
<223>  n is a, c, g, or t

<400>  56
cgcggttcag gaaggattca atnnkgacaa tc                                     32


<210>  57
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cebador F121 R


<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  n is a, c, g, or t

<400>  57
catactggcg tcgccttcmn nggtgccatg c                                      31


<210>  58
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cebador F121 F


<220>
<221>  misc_feature
<222>  (22)..(23)
<223>  n is a, c, g, or t

<400>  58
ggactcaatg agcatggcac cnnkgaaggc g                                      31


<210>  59
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cebador F199 R


<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  n is a, c, g, or t

<400>  59
ccacaaaaag attcgcgggm nnggtggtct cg                                     32


<210>  60
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cebador F199 F


<220>
<221>  misc_feature
<222>  (24)..(25)
<223>  n is a, c, g, or t

<400>  60
ctactgctta cggcgagacc accnnkcccg cg                                     32


<210>  61
<211>  987
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variante wt-SoLo sin pptido seal


<220>
<221>  CDS
<222>  (1)..(987)

<400>  61
gag cca gga tta cct cct ggt cct ctc gag aat agc tct gca aag ttg         48
Glu Pro Gly Leu Pro Pro Gly Pro Leu Glu Asn Ser Ser Ala Lys Leu           
1               5                   10                  15                

gtg aac gac gag gct cac cca tgg aag ccg ctt cga cct ggc gat att         96
Val Asn Asp Glu Ala His Pro Trp Lys Pro Leu Arg Pro Gly Asp Ile           
            20                  25                  30                    

cgt gga cct tgc cct ggt ctc aat act ctg gca tct cac ggg tac ctc        144
Arg Gly Pro Cys Pro Gly Leu Asn Thr Leu Ala Ser His Gly Tyr Leu           
        35                  40                  45                        

ccg aga aat ggc gtt gca acc ccg gtg caa ata ata aac gcg gtt cag        192
Pro Arg Asn Gly Val Ala Thr Pro Val Gln Ile Ile Asn Ala Val Gln           
    50                  55                  60                            

gaa gga ctc aat ttc gac aat caa gcc gca gtc ttc gcc aca tat gcg        240
Glu Gly Leu Asn Phe Asp Asn Gln Ala Ala Val Phe Ala Thr Tyr Ala           
65                  70                  75                  80            

gcc cac ctt gtg gac ggc aat ctc att acg gac ttg ctg agc atc gga        288
Ala His Leu Val Asp Gly Asn Leu Ile Thr Asp Leu Leu Ser Ile Gly           
                85                  90                  95                

cgc aag acg cgg ctc act ggg cct gat cca cca ccc ccc gct tcc gtt        336
Arg Lys Thr Arg Leu Thr Gly Pro Asp Pro Pro Pro Pro Ala Ser Val           
            100                 105                 110                   

ggt gga ctc aat gag cat ggc acc ttc gaa ggc gac gcc agt atg acc        384
Gly Gly Leu Asn Glu His Gly Thr Phe Glu Gly Asp Ala Ser Met Thr           
        115                 120                 125                       

cga ggt gac gca ttc ttt ggc aac aac cac gat ttc aat gag acg ctc        432
Arg Gly Asp Ala Phe Phe Gly Asn Asn His Asp Phe Asn Glu Thr Leu           
    130                 135                 140                           

ttc gaa cag ttg gtt gac tac agc aac cga ttt gga gga gga aaa tac        480
Phe Glu Gln Leu Val Asp Tyr Ser Asn Arg Phe Gly Gly Gly Lys Tyr           
145                 150                 155                 160           

aat ctt acc gtc gcg ggg gag ctc cgt ttc aag cgc att caa gac tcc        528
Asn Leu Thr Val Ala Gly Glu Leu Arg Phe Lys Arg Ile Gln Asp Ser           
                165                 170                 175               

att gcg acc aac ccc aat ttc tcc ttt gtt gac ttt agg ttc tct act        576
Ile Ala Thr Asn Pro Asn Phe Ser Phe Val Asp Phe Arg Phe Ser Thr           
            180                 185                 190                   

gct tac ggc gag acc acc ttc ccc gcg aat ctt ttt gtg gat ggg cgc        624
Ala Tyr Gly Glu Thr Thr Phe Pro Ala Asn Leu Phe Val Asp Gly Arg           
        195                 200                 205                       

agg gac gac ggc cag cta gat atg gat gct gca cgg agt ttt ttc caa        672
Arg Asp Asp Gly Gln Leu Asp Met Asp Ala Ala Arg Ser Phe Phe Gln           
    210                 215                 220                           

ttc agc cgt atg cct gac gat ttc ttc cgc gca ccc agc ccg aga agt        720
Phe Ser Arg Met Pro Asp Asp Phe Phe Arg Ala Pro Ser Pro Arg Ser           
225                 230                 235                 240           

ggc aca gga gtc gag gta gtt ata cag gct cat cct atg cag ccc gga        768
Gly Thr Gly Val Glu Val Val Ile Gln Ala His Pro Met Gln Pro Gly           
                245                 250                 255               

aga aat gtc ggc aag atc aac agc tac acc gtc gac cca aca tcc tct        816
Arg Asn Val Gly Lys Ile Asn Ser Tyr Thr Val Asp Pro Thr Ser Ser           
            260                 265                 270                   

gac ttt tcc acc ccc tgc ttg atg tac gag aaa ttc gtc aac ata acg        864
Asp Phe Ser Thr Pro Cys Leu Met Tyr Glu Lys Phe Val Asn Ile Thr           
        275                 280                 285                       

gtc aag tca ctc tac ccg aat ccg acg gtg cag ctt cgc aaa gcc ctt        912
Val Lys Ser Leu Tyr Pro Asn Pro Thr Val Gln Leu Arg Lys Ala Leu           
    290                 295                 300                           

aat acg aat ctc gat ttc ttc ttc cag gga gtc gcc gct gga tgt acc        960
Asn Thr Asn Leu Asp Phe Phe Phe Gln Gly Val Ala Ala Gly Cys Thr           
305                 310                 315                 320           

cag gtc ttc cca tac ggg cga gat tga                                    987
Gln Val Phe Pro Tyr Gly Arg Asp                                           
                325                                                       


<210>  62
<211>  328
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  62

Glu Pro Gly Leu Pro Pro Gly Pro Leu Glu Asn Ser Ser Ala Lys Leu 
1               5                   10                  15      


Val Asn Asp Glu Ala His Pro Trp Lys Pro Leu Arg Pro Gly Asp Ile 
            20                  25                  30          


Arg Gly Pro Cys Pro Gly Leu Asn Thr Leu Ala Ser His Gly Tyr Leu 
        35                  40                  45              


Pro Arg Asn Gly Val Ala Thr Pro Val Gln Ile Ile Asn Ala Val Gln 
    50                  55                  60                  


Glu Gly Leu Asn Phe Asp Asn Gln Ala Ala Val Phe Ala Thr Tyr Ala 
65                  70                  75                  80  


Ala His Leu Val Asp Gly Asn Leu Ile Thr Asp Leu Leu Ser Ile Gly 
                85                  90                  95      


Arg Lys Thr Arg Leu Thr Gly Pro Asp Pro Pro Pro Pro Ala Ser Val 
            100                 105                 110         


Gly Gly Leu Asn Glu His Gly Thr Phe Glu Gly Asp Ala Ser Met Thr 
        115                 120                 125             


Arg Gly Asp Ala Phe Phe Gly Asn Asn His Asp Phe Asn Glu Thr Leu 
    130                 135                 140                 


Phe Glu Gln Leu Val Asp Tyr Ser Asn Arg Phe Gly Gly Gly Lys Tyr 
145                 150                 155                 160 


Asn Leu Thr Val Ala Gly Glu Leu Arg Phe Lys Arg Ile Gln Asp Ser 
                165                 170                 175     


Ile Ala Thr Asn Pro Asn Phe Ser Phe Val Asp Phe Arg Phe Ser Thr 
            180                 185                 190         


Ala Tyr Gly Glu Thr Thr Phe Pro Ala Asn Leu Phe Val Asp Gly Arg 
        195                 200                 205             


Arg Asp Asp Gly Gln Leu Asp Met Asp Ala Ala Arg Ser Phe Phe Gln 
    210                 215                 220                 


Phe Ser Arg Met Pro Asp Asp Phe Phe Arg Ala Pro Ser Pro Arg Ser 
225                 230                 235                 240 


Gly Thr Gly Val Glu Val Val Ile Gln Ala His Pro Met Gln Pro Gly 
                245                 250                 255     


Arg Asn Val Gly Lys Ile Asn Ser Tyr Thr Val Asp Pro Thr Ser Ser 
            260                 265                 270         


Asp Phe Ser Thr Pro Cys Leu Met Tyr Glu Lys Phe Val Asn Ile Thr 
        275                 280                 285             


Val Lys Ser Leu Tyr Pro Asn Pro Thr Val Gln Leu Arg Lys Ala Leu 
    290                 295                 300                 


Asn Thr Asn Leu Asp Phe Phe Phe Gln Gly Val Ala Ala Gly Cys Thr 
305                 310                 315                 320 


Gln Val Phe Pro Tyr Gly Arg Asp 
                325             


<210>  63
<211>  1116
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variante wt-SoLo con pptido seal silvestre


<220>
<221>  CDS
<222>  (1)..(1113)

<220>
<221>  mat_peptide
<222>  (130)..(1116)

<400>  63
atg aaa tat ttt ccc ctg ttc cca acc ttg gtc tac gca gtg ggg gtc         48
Met Lys Tyr Phe Pro Leu Phe Pro Thr Leu Val Tyr Ala Val Gly Val           
            -40                 -35                 -30                   

gtt gct ttt cct gac tac gcc tca ttg gcc ggc ctc agc cag cag gaa         96
Val Ala Phe Pro Asp Tyr Ala Ser Leu Ala Gly Leu Ser Gln Gln Glu           
        -25                 -20                 -15                       

ttg gac gct ata atc cca aca ctc gag gcc cga gag cca gga tta cct        144
Leu Asp Ala Ile Ile Pro Thr Leu Glu Ala Arg Glu Pro Gly Leu Pro           
    -10                 -5              -1  1               5             

cct ggt cct ctc gag aat agc tct gca aag ttg gtg aac gac gag gct        192
Pro Gly Pro Leu Glu Asn Ser Ser Ala Lys Leu Val Asn Asp Glu Ala           
                10                  15                  20                

cac cca tgg aag ccg ctt cga cct ggc gat att cgt gga cct tgc cct        240
His Pro Trp Lys Pro Leu Arg Pro Gly Asp Ile Arg Gly Pro Cys Pro           
            25                  30                  35                    

ggt ctc aat act ctg gca tct cac ggg tac ctc ccg aga aat ggc gtt        288
Gly Leu Asn Thr Leu Ala Ser His Gly Tyr Leu Pro Arg Asn Gly Val           
        40                  45                  50                        

gca acc ccg gtg caa ata ata aac gcg gtt cag gaa gga ctc aat ttc        336
Ala Thr Pro Val Gln Ile Ile Asn Ala Val Gln Glu Gly Leu Asn Phe           
    55                  60                  65                            

gac aat caa gcc gca gtc ttc gcc aca tat gcg gcc cac ctt gtg gac        384
Asp Asn Gln Ala Ala Val Phe Ala Thr Tyr Ala Ala His Leu Val Asp           
70                  75                  80                  85            

ggc aat ctc att acg gac ttg ctg agc atc gga cgc aag acg cgg ctc        432
Gly Asn Leu Ile Thr Asp Leu Leu Ser Ile Gly Arg Lys Thr Arg Leu           
                90                  95                  100               

act ggg cct gat cca cca ccc ccc gct tcc gtt ggt gga ctc aat gag        480
Thr Gly Pro Asp Pro Pro Pro Pro Ala Ser Val Gly Gly Leu Asn Glu           
            105                 110                 115                   

cat ggc acc ttc gaa ggc gac gcc agt atg acc cga ggt gac gca ttc        528
His Gly Thr Phe Glu Gly Asp Ala Ser Met Thr Arg Gly Asp Ala Phe           
        120                 125                 130                       

ttt ggc aac aac cac gat ttc aat gag acg ctc ttc gaa cag ttg gtt        576
Phe Gly Asn Asn His Asp Phe Asn Glu Thr Leu Phe Glu Gln Leu Val           
    135                 140                 145                           

gac tac agc aac cga ttt gga gga gga aaa tac aat ctt acc gtc gcg        624
Asp Tyr Ser Asn Arg Phe Gly Gly Gly Lys Tyr Asn Leu Thr Val Ala           
150                 155                 160                 165           

ggg gag ctc cgt ttc aag cgc att caa gac tcc att gcg acc aac ccc        672
Gly Glu Leu Arg Phe Lys Arg Ile Gln Asp Ser Ile Ala Thr Asn Pro           
                170                 175                 180               

aat ttc tcc ttt gtt gac ttt agg ttc tct act gct tac ggc gag acc        720
Asn Phe Ser Phe Val Asp Phe Arg Phe Ser Thr Ala Tyr Gly Glu Thr           
            185                 190                 195                   

acc ttc ccc gcg aat ctt ttt gtg gat ggg cgc agg gac gac ggc cag        768
Thr Phe Pro Ala Asn Leu Phe Val Asp Gly Arg Arg Asp Asp Gly Gln           
        200                 205                 210                       

cta gat atg gat gct gca cgg agt ttt ttc caa ttc agc cgt atg cct        816
Leu Asp Met Asp Ala Ala Arg Ser Phe Phe Gln Phe Ser Arg Met Pro           
    215                 220                 225                           

gac gat ttc ttc cgc gca ccc agc ccg aga agt ggc aca gga gtc gag        864
Asp Asp Phe Phe Arg Ala Pro Ser Pro Arg Ser Gly Thr Gly Val Glu           
230                 235                 240                 245           

gta gtt ata cag gct cat cct atg cag ccc gga aga aat gtc ggc aag        912
Val Val Ile Gln Ala His Pro Met Gln Pro Gly Arg Asn Val Gly Lys           
                250                 255                 260               

atc aac agc tac acc gtc gac cca aca tcc tct gac ttt tcc acc ccc        960
Ile Asn Ser Tyr Thr Val Asp Pro Thr Ser Ser Asp Phe Ser Thr Pro           
            265                 270                 275                   

tgc ttg atg tac gag aaa ttc gtc aac ata acg gtc aag tca ctc tac       1008
Cys Leu Met Tyr Glu Lys Phe Val Asn Ile Thr Val Lys Ser Leu Tyr           
        280                 285                 290                       

ccg aat ccg acg gtg cag ctt cgc aaa gcc ctt aat acg aat ctc gat       1056
Pro Asn Pro Thr Val Gln Leu Arg Lys Ala Leu Asn Thr Asn Leu Asp           
    295                 300                 305                           

ttc ttc ttc cag gga gtc gcc gct gga tgt acc cag gtc ttc cca tac       1104
Phe Phe Phe Gln Gly Val Ala Ala Gly Cys Thr Gln Val Phe Pro Tyr           
310                 315                 320                 325           

ggg cga gat tga                                                       1116
Gly Arg Asp                                                               
                                                                          


<210>  64
<211>  371
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  64

Met Lys Tyr Phe Pro Leu Phe Pro Thr Leu Val Tyr Ala Val Gly Val 
            -40                 -35                 -30         


Val Ala Phe Pro Asp Tyr Ala Ser Leu Ala Gly Leu Ser Gln Gln Glu 
        -25                 -20                 -15             


Leu Asp Ala Ile Ile Pro Thr Leu Glu Ala Arg Glu Pro Gly Leu Pro 
    -10                 -5              -1  1               5   


Pro Gly Pro Leu Glu Asn Ser Ser Ala Lys Leu Val Asn Asp Glu Ala 
                10                  15                  20      


His Pro Trp Lys Pro Leu Arg Pro Gly Asp Ile Arg Gly Pro Cys Pro 
            25                  30                  35          


Gly Leu Asn Thr Leu Ala Ser His Gly Tyr Leu Pro Arg Asn Gly Val 
        40                  45                  50              


Ala Thr Pro Val Gln Ile Ile Asn Ala Val Gln Glu Gly Leu Asn Phe 
    55                  60                  65                  


Asp Asn Gln Ala Ala Val Phe Ala Thr Tyr Ala Ala His Leu Val Asp 
70                  75                  80                  85  


Gly Asn Leu Ile Thr Asp Leu Leu Ser Ile Gly Arg Lys Thr Arg Leu 
                90                  95                  100     


Thr Gly Pro Asp Pro Pro Pro Pro Ala Ser Val Gly Gly Leu Asn Glu 
            105                 110                 115         


His Gly Thr Phe Glu Gly Asp Ala Ser Met Thr Arg Gly Asp Ala Phe 
        120                 125                 130             


Phe Gly Asn Asn His Asp Phe Asn Glu Thr Leu Phe Glu Gln Leu Val 
    135                 140                 145                 


Asp Tyr Ser Asn Arg Phe Gly Gly Gly Lys Tyr Asn Leu Thr Val Ala 
150                 155                 160                 165 


Gly Glu Leu Arg Phe Lys Arg Ile Gln Asp Ser Ile Ala Thr Asn Pro 
                170                 175                 180     


Asn Phe Ser Phe Val Asp Phe Arg Phe Ser Thr Ala Tyr Gly Glu Thr 
            185                 190                 195         


Thr Phe Pro Ala Asn Leu Phe Val Asp Gly Arg Arg Asp Asp Gly Gln 
        200                 205                 210             


Leu Asp Met Asp Ala Ala Arg Ser Phe Phe Gln Phe Ser Arg Met Pro 
    215                 220                 225                 


Asp Asp Phe Phe Arg Ala Pro Ser Pro Arg Ser Gly Thr Gly Val Glu 
230                 235                 240                 245 


Val Val Ile Gln Ala His Pro Met Gln Pro Gly Arg Asn Val Gly Lys 
                250                 255                 260     


Ile Asn Ser Tyr Thr Val Asp Pro Thr Ser Ser Asp Phe Ser Thr Pro 
            265                 270                 275         


Cys Leu Met Tyr Glu Lys Phe Val Asn Ile Thr Val Lys Ser Leu Tyr 
        280                 285                 290             


Pro Asn Pro Thr Val Gln Leu Arg Lys Ala Leu Asn Thr Asn Leu Asp 
    295                 300                 305                 


Phe Phe Phe Gln Gly Val Ala Ala Gly Cys Thr Gln Val Phe Pro Tyr 
310                 315                 320                 325 


Gly Arg Asp 
            


<210>  65
<211>  1116
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variante wt-SoLo con pptido seal modificado


<220>
<221>  CDS
<222>  (1)..(1113)

<220>
<221>  mat_peptide
<222>  (130)..(1116)

<400>  65
atg aaa tat ttt ccc ctg ttc cca acc ttg gtc tac gca gtg ggg gtc         48
Met Lys Tyr Phe Pro Leu Phe Pro Thr Leu Val Tyr Ala Val Gly Val           
            -40                 -35                 -30                   

gtt gct ttt cct gac tac gcc tca ttg gcc ggc ctc agc cag cag gaa         96
Val Ala Phe Pro Asp Tyr Ala Ser Leu Ala Gly Leu Ser Gln Gln Glu           
        -25                 -20                 -15                       

ttg gac gct ata atc cca aca ctc gag gcc cga gag cca gga tta cct        144
Leu Asp Ala Ile Ile Pro Thr Leu Glu Ala Arg Glu Pro Gly Leu Pro           
    -10                 -5              -1  1               5             

cct ggt cct ctc gag aat agc tct gca aag ttg gtg aac gac gag gct        192
Pro Gly Pro Leu Glu Asn Ser Ser Ala Lys Leu Val Asn Asp Glu Ala           
                10                  15                  20                

cac cca tgg aag ccg ctt cga cct ggc gat att cgt gga cct tgc cct        240
His Pro Trp Lys Pro Leu Arg Pro Gly Asp Ile Arg Gly Pro Cys Pro           
            25                  30                  35                    

ggt ctc aat act ctg gca tct cac ggg tac ctc ccg aga aat ggc gtt        288
Gly Leu Asn Thr Leu Ala Ser His Gly Tyr Leu Pro Arg Asn Gly Val           
        40                  45                  50                        

gca acc ccg gtg caa ata ata aac gcg gtt cag gaa gga ctc aat ttc        336
Ala Thr Pro Val Gln Ile Ile Asn Ala Val Gln Glu Gly Leu Asn Phe           
    55                  60                  65                            

gac aat caa gcc gca gtc ttc gcc aca tat gcg gcc cac ctt gtg gac        384
Asp Asn Gln Ala Ala Val Phe Ala Thr Tyr Ala Ala His Leu Val Asp           
70                  75                  80                  85            

ggc aat ctc att acg gac ttg ctg agc atc gga cgc aag acg cgg ctc        432
Gly Asn Leu Ile Thr Asp Leu Leu Ser Ile Gly Arg Lys Thr Arg Leu           
                90                  95                  100               

act ggg cct gat cca cca ccc ccc gct tcc gtt ggt gga ctc aat gag        480
Thr Gly Pro Asp Pro Pro Pro Pro Ala Ser Val Gly Gly Leu Asn Glu           
            105                 110                 115                   

cat ggc acc ttc gaa ggc gac gcc agt atg acc cga ggt gac gca ttc        528
His Gly Thr Phe Glu Gly Asp Ala Ser Met Thr Arg Gly Asp Ala Phe           
        120                 125                 130                       

ttt ggc aac aac cac gat ttc aat gag acg ctc ttc gaa cag ttg gtt        576
Phe Gly Asn Asn His Asp Phe Asn Glu Thr Leu Phe Glu Gln Leu Val           
    135                 140                 145                           

gac tac agc aac cga ttt gga gga gga aaa tac aat ctt acc gtc gcg        624
Asp Tyr Ser Asn Arg Phe Gly Gly Gly Lys Tyr Asn Leu Thr Val Ala           
150                 155                 160                 165           

ggg gag ctc cgt ttc aag cgc att caa gac tcc att gcg acc aac ccc        672
Gly Glu Leu Arg Phe Lys Arg Ile Gln Asp Ser Ile Ala Thr Asn Pro           
                170                 175                 180               

aat ttc tcc ttt gtt gac ttt agg ttc tct act gct tac ggc gag acc        720
Asn Phe Ser Phe Val Asp Phe Arg Phe Ser Thr Ala Tyr Gly Glu Thr           
            185                 190                 195                   

acc ttc ccc gcg aat ctt ttt gtg gat ggg cgc agg gac gac ggc cag        768
Thr Phe Pro Ala Asn Leu Phe Val Asp Gly Arg Arg Asp Asp Gly Gln           
        200                 205                 210                       

cta gat atg gat gct gca cgg agt ttt ttc caa ttc agc cgt atg cct        816
Leu Asp Met Asp Ala Ala Arg Ser Phe Phe Gln Phe Ser Arg Met Pro           
    215                 220                 225                           

gac gat ttc ttc cgc gca ccc agc ccg aga agt ggc aca gga gtc gag        864
Asp Asp Phe Phe Arg Ala Pro Ser Pro Arg Ser Gly Thr Gly Val Glu           
230                 235                 240                 245           

gta gtt ata cag gct cat cct atg cag ccc gga aga aat gtc ggc aag        912
Val Val Ile Gln Ala His Pro Met Gln Pro Gly Arg Asn Val Gly Lys           
                250                 255                 260               

atc aac agc tac acc gtc gac cca aca tcc tct gac ttt tcc acc ccc        960
Ile Asn Ser Tyr Thr Val Asp Pro Thr Ser Ser Asp Phe Ser Thr Pro           
            265                 270                 275                   

tgc ttg atg tac gag aaa ttc gtc aac ata acg gtc aag tca ctc tac       1008
Cys Leu Met Tyr Glu Lys Phe Val Asn Ile Thr Val Lys Ser Leu Tyr           
        280                 285                 290                       

ccg aat ccg acg gtg cag ctt cgc aaa gcc ctt aat acg aat ctc gat       1056
Pro Asn Pro Thr Val Gln Leu Arg Lys Ala Leu Asn Thr Asn Leu Asp           
    295                 300                 305                           

ttc ttc ttc cag gga gtc gcc gct gga tgt acc cag gtc ttc cca tac       1104
Phe Phe Phe Gln Gly Val Ala Ala Gly Cys Thr Gln Val Phe Pro Tyr           
310                 315                 320                 325           

ggg cga gat tga                                                       1116
Gly Arg Asp                                                               
                                                                          


<210>  66
<211>  371
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  66

Met Lys Tyr Phe Pro Leu Phe Pro Thr Leu Val Tyr Ala Val Gly Val 
            -40                 -35                 -30         


Val Ala Phe Pro Asp Tyr Ala Ser Leu Ala Gly Leu Ser Gln Gln Glu 
        -25                 -20                 -15             


Leu Asp Ala Ile Ile Pro Thr Leu Glu Ala Arg Glu Pro Gly Leu Pro 
    -10                 -5              -1  1               5   


Pro Gly Pro Leu Glu Asn Ser Ser Ala Lys Leu Val Asn Asp Glu Ala 
                10                  15                  20      


His Pro Trp Lys Pro Leu Arg Pro Gly Asp Ile Arg Gly Pro Cys Pro 
            25                  30                  35          


Gly Leu Asn Thr Leu Ala Ser His Gly Tyr Leu Pro Arg Asn Gly Val 
        40                  45                  50              


Ala Thr Pro Val Gln Ile Ile Asn Ala Val Gln Glu Gly Leu Asn Phe 
    55                  60                  65                  


Asp Asn Gln Ala Ala Val Phe Ala Thr Tyr Ala Ala His Leu Val Asp 
70                  75                  80                  85  


Gly Asn Leu Ile Thr Asp Leu Leu Ser Ile Gly Arg Lys Thr Arg Leu 
                90                  95                  100     


Thr Gly Pro Asp Pro Pro Pro Pro Ala Ser Val Gly Gly Leu Asn Glu 
            105                 110                 115         


His Gly Thr Phe Glu Gly Asp Ala Ser Met Thr Arg Gly Asp Ala Phe 
        120                 125                 130             


Phe Gly Asn Asn His Asp Phe Asn Glu Thr Leu Phe Glu Gln Leu Val 
    135                 140                 145                 


Asp Tyr Ser Asn Arg Phe Gly Gly Gly Lys Tyr Asn Leu Thr Val Ala 
150                 155                 160                 165 


Gly Glu Leu Arg Phe Lys Arg Ile Gln Asp Ser Ile Ala Thr Asn Pro 
                170                 175                 180     


Asn Phe Ser Phe Val Asp Phe Arg Phe Ser Thr Ala Tyr Gly Glu Thr 
            185                 190                 195         


Thr Phe Pro Ala Asn Leu Phe Val Asp Gly Arg Arg Asp Asp Gly Gln 
        200                 205                 210             


Leu Asp Met Asp Ala Ala Arg Ser Phe Phe Gln Phe Ser Arg Met Pro 
    215                 220                 225                 


Asp Asp Phe Phe Arg Ala Pro Ser Pro Arg Ser Gly Thr Gly Val Glu 
230                 235                 240                 245 


Val Val Ile Gln Ala His Pro Met Gln Pro Gly Arg Asn Val Gly Lys 
                250                 255                 260     


Ile Asn Ser Tyr Thr Val Asp Pro Thr Ser Ser Asp Phe Ser Thr Pro 
            265                 270                 275         


Cys Leu Met Tyr Glu Lys Phe Val Asn Ile Thr Val Lys Ser Leu Tyr 
        280                 285                 290             


Pro Asn Pro Thr Val Gln Leu Arg Lys Ala Leu Asn Thr Asn Leu Asp 
    295                 300                 305                 


Phe Phe Phe Gln Gly Val Ala Ala Gly Cys Thr Gln Val Phe Pro Tyr 
310                 315                 320                 325 


Gly Arg Asp 
            


