                         SEQUENCE LISTING

<110>  ABLYNX NV
 
<120>  IMPROVED P2X7 RECEPTOR BINDERS AND POLYPEPTIDES COMPRISING THE 
       SAME

<130>  192516

<150>  US 62/254298
<151>  2015-11-12

<160>  177   

<170>  PatentIn version 3.5

<210>  1
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  1

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Arg His Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Ser Tyr Gly Ser Thr Asp Tyr Gly Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn Thr Val Pro Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Ala Asp Glu Thr Leu Gly Ala Val Pro Asn Phe Arg Leu His Glu 
            100                 105                 110         


Lys Tyr Glu Tyr Glu Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  2
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  2

His Tyr Ala Met Gly 
1               5   


<210>  3
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  3

Ala Ile Ser Ser Tyr Gly Ser Thr Asp Tyr Gly Asp Ser Val Lys Gly 
1               5                   10                  15      


<210>  4
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  4

Ala Asp Glu Thr Leu Gly Ala Val Pro Asn Phe Arg Leu His Glu Lys 
1               5                   10                  15      


Tyr Glu Tyr Glu Tyr 
            20      


<210>  5
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  5

Gly Arg Thr Phe Arg His Tyr Ala Met Gly 
1               5                   10  


<210>  6
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  6

Ala Ile Ser Ser Tyr Gly Ser Thr Asp 
1               5                   


<210>  7
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  7

Ala Asp Glu Thr Leu Gly Ala Val Pro Asn Phe Arg Leu His Glu Lys 
1               5                   10                  15      


Tyr Glu Tyr Glu Tyr 
            20      


<210>  8
<211>  130
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  8

Glu Val Gln Leu Val Glu Ser Gly Gly Lys Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Arg Thr Phe Ser Phe Ser 
            20                  25                  30          


Thr Ser Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Leu Glu 
        35                  40                  45              


Phe Val Ala Ala Ile Asp Trp Ser Asp Phe Asn Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg His Asn Pro Arg Asn Ser 
65                  70                  75                  80  


Val Tyr Leu Gln Leu Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Ala His Ser Glu Thr Arg Gly Gly Thr Arg Tyr Phe Asp 
            100                 105                 110         


Arg Pro Ser Leu Tyr Asn Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
        115                 120                 125             


Ser Ser 
    130 


<210>  9
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  9

Phe Ser Thr Ser Thr Met Gly 
1               5           


<210>  10
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  10

Ala Ile Asp Trp Ser Asp Phe Asn Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  11
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  11

His Ser Glu Thr Arg Gly Gly Thr Arg Tyr Phe Asp Arg Pro Ser Leu 
1               5                   10                  15      


Tyr Asn Tyr 
            


<210>  12
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  12

Gly Arg Thr Phe Ser Phe Ser Thr Ser Thr Met Gly 
1               5                   10          


<210>  13
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  13

Ala Ile Asp Trp Ser Asp Phe Asn Thr Tyr 
1               5                   10  


<210>  14
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  14

His Ser Glu Thr Arg Gly Gly Thr Arg Tyr Phe Asp Arg Pro Ser Leu 
1               5                   10                  15      


Tyr Asn Tyr 
            


<210>  15
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  15

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Arg His Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Ser Tyr Gly Ser Thr Asp Tyr Gly Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn Thr Val Pro Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Thr Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Ala Asp Glu Thr Leu Gly Ala Val Pro Asn Phe Arg Leu His Glu 
            100                 105                 110         


Lys Tyr Glu Tyr Glu Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  16
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  16

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Arg His Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Ser Tyr Gly Ser Thr Asp Tyr Gly Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn Thr Val Pro Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Ala Asp Glu Thr Leu Gly Ala Val Pro Asn Phe Arg Leu His Glu 
            100                 105                 110         


Lys Tyr Glu Tyr Glu Tyr Trp Gly Gln Gly Thr Leu Val Lys Val Ser 
        115                 120                 125             


Ser 
    


<210>  17
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  17

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Arg His Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Ser Tyr Gly Ser Thr Asp Tyr Gly Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn Thr Val Pro Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Ala Asp Glu Thr Leu Gly Ala Val Pro Asn Phe Arg Leu His Glu 
            100                 105                 110         


Lys Tyr Glu Tyr Glu Tyr Trp Gly Gln Gly Thr Leu Val Gln Val Ser 
        115                 120                 125             


Ser 
    


<210>  18
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  18

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Arg His Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Ser Tyr Gly Ser Thr Asp Tyr Gly Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn Thr Val Pro Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Ala Asp Glu Thr Leu Gly Ala Val Pro Asn Phe Arg Leu His Glu 
            100                 105                 110         


Lys Tyr Glu Tyr Glu Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Lys 
        115                 120                 125             


Ser 
    


<210>  19
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  19

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Arg His Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Ser Tyr Gly Ser Thr Asp Tyr Gly Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn Thr Val Pro Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Ala Asp Glu Thr Leu Gly Ala Val Pro Asn Phe Arg Leu His Glu 
            100                 105                 110         


Lys Tyr Glu Tyr Glu Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Gln 
        115                 120                 125             


Ser 
    


<210>  20
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  20

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Arg His Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Ser Tyr Gly Ser Thr Asp Tyr Gly Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn Thr Val Pro Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Ala Asp Glu Thr Leu Gly Ala Val Pro Asn Phe Arg Leu His Glu 
            100                 105                 110         


Lys Tyr Glu Tyr Glu Tyr Trp Gly Gln Gly Thr Leu Val Lys Val Ser 
        115                 120                 125             


Ser 
    


<210>  21
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  21

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Arg His Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Ser Tyr Gly Ser Thr Asp Tyr Gly Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn Thr Val Pro Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Ala Asp Glu Thr Leu Gly Ala Val Pro Asn Phe Arg Leu His Glu 
            100                 105                 110         


Lys Tyr Glu Tyr Glu Tyr Trp Gly Gln Gly Thr Leu Val Gln Val Ser 
        115                 120                 125             


Ser 
    


<210>  22
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  22

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Arg His Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Ser Tyr Gly Ser Thr Asp Tyr Gly Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn Thr Val Pro Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Ala Asp Glu Thr Leu Gly Ala Val Pro Asn Phe Arg Leu His Glu 
            100                 105                 110         


Lys Tyr Glu Tyr Glu Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Lys 
        115                 120                 125             


Ser 
    


<210>  23
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  23

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Arg His Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Ser Tyr Gly Ser Thr Asp Tyr Gly Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn Thr Val Pro Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Ala Asp Glu Thr Leu Gly Ala Val Pro Asn Phe Arg Leu His Glu 
            100                 105                 110         


Lys Tyr Glu Tyr Glu Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Gln 
        115                 120                 125             


Ser 
    


<210>  24
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  24

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Arg His Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Ser Tyr Gly Ser Thr Asp Tyr Gly Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn Thr Val Pro Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Ala Asp Glu Thr Leu Gly Ala Val Pro Asn Phe Arg Leu His Glu 
            100                 105                 110         


Lys Tyr Glu Tyr Glu Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  25
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  25

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Arg His Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Ser Tyr Gly Ser Thr Asp Tyr Gly Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn Thr Val Pro Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Ala Asp Glu Thr Leu Gly Ala Val Pro Asn Phe Arg Leu His Glu 
            100                 105                 110         


Lys Tyr Glu Tyr Glu Tyr Trp Gly Gln Gly Thr Leu Val Lys Val Ser 
        115                 120                 125             


Ser 
    


<210>  26
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  26

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Arg His Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Ser Tyr Gly Ser Thr Asp Tyr Gly Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn Thr Val Pro Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Ala Asp Glu Thr Leu Gly Ala Val Pro Asn Phe Arg Leu His Glu 
            100                 105                 110         


Lys Tyr Glu Tyr Glu Tyr Trp Gly Gln Gly Thr Leu Val Gln Val Ser 
        115                 120                 125             


Ser 
    


<210>  27
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  27

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Arg His Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Ser Tyr Gly Ser Thr Asp Tyr Gly Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn Thr Val Pro Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Ala Asp Glu Thr Leu Gly Ala Val Pro Asn Phe Arg Leu His Glu 
            100                 105                 110         


Lys Tyr Glu Tyr Glu Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Lys 
        115                 120                 125             


Ser 
    


<210>  28
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  28

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Arg His Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Ser Tyr Gly Ser Thr Asp Tyr Gly Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn Thr Val Pro Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Ala Asp Glu Thr Leu Gly Ala Val Pro Asn Phe Arg Leu His Glu 
            100                 105                 110         


Lys Tyr Glu Tyr Glu Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Gln 
        115                 120                 125             


Ser 
    


<210>  29
<211>  130
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  29

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Arg His Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Ser Tyr Gly Ser Thr Asp Tyr Gly Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn Thr Val Pro Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Thr Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Ala Asp Glu Thr Leu Gly Ala Val Pro Asn Phe Arg Leu His Glu 
            100                 105                 110         


Lys Tyr Glu Tyr Glu Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        115                 120                 125             


Ser Ala 
    130 


<210>  30
<211>  130
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  30

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Arg His Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Ser Tyr Gly Ser Thr Asp Tyr Gly Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn Thr Val Pro Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Ala Asp Glu Thr Leu Gly Ala Val Pro Asn Phe Arg Leu His Glu 
            100                 105                 110         


Lys Tyr Glu Tyr Glu Tyr Trp Gly Gln Gly Thr Leu Val Lys Val Ser 
        115                 120                 125             


Ser Ala 
    130 


<210>  31
<211>  130
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  31

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Arg His Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Ser Tyr Gly Ser Thr Asp Tyr Gly Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn Thr Val Pro Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Ala Asp Glu Thr Leu Gly Ala Val Pro Asn Phe Arg Leu His Glu 
            100                 105                 110         


Lys Tyr Glu Tyr Glu Tyr Trp Gly Gln Gly Thr Leu Val Gln Val Ser 
        115                 120                 125             


Ser Ala 
    130 


<210>  32
<211>  130
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  32

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Arg His Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Ser Tyr Gly Ser Thr Asp Tyr Gly Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn Thr Val Pro Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Ala Asp Glu Thr Leu Gly Ala Val Pro Asn Phe Arg Leu His Glu 
            100                 105                 110         


Lys Tyr Glu Tyr Glu Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Lys 
        115                 120                 125             


Ser Ala 
    130 


<210>  33
<211>  130
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  33

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Arg His Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Ser Tyr Gly Ser Thr Asp Tyr Gly Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn Thr Val Pro Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Ala Asp Glu Thr Leu Gly Ala Val Pro Asn Phe Arg Leu His Glu 
            100                 105                 110         


Lys Tyr Glu Tyr Glu Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Gln 
        115                 120                 125             


Ser Ala 
    130 


<210>  34
<211>  130
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  34

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Arg His Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Ser Tyr Gly Ser Thr Asp Tyr Gly Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn Thr Val Pro Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Ala Asp Glu Thr Leu Gly Ala Val Pro Asn Phe Arg Leu His Glu 
            100                 105                 110         


Lys Tyr Glu Tyr Glu Tyr Trp Gly Gln Gly Thr Leu Val Lys Val Ser 
        115                 120                 125             


Ser Ala 
    130 


<210>  35
<211>  130
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  35

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Arg His Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Ser Tyr Gly Ser Thr Asp Tyr Gly Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn Thr Val Pro Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Ala Asp Glu Thr Leu Gly Ala Val Pro Asn Phe Arg Leu His Glu 
            100                 105                 110         


Lys Tyr Glu Tyr Glu Tyr Trp Gly Gln Gly Thr Leu Val Gln Val Ser 
        115                 120                 125             


Ser Ala 
    130 


<210>  36
<211>  130
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  36

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Arg His Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Ser Tyr Gly Ser Thr Asp Tyr Gly Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn Thr Val Pro Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Ala Asp Glu Thr Leu Gly Ala Val Pro Asn Phe Arg Leu His Glu 
            100                 105                 110         


Lys Tyr Glu Tyr Glu Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Lys 
        115                 120                 125             


Ser Ala 
    130 


<210>  37
<211>  130
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  37

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Arg His Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Ser Tyr Gly Ser Thr Asp Tyr Gly Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn Thr Val Pro Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Ala Asp Glu Thr Leu Gly Ala Val Pro Asn Phe Arg Leu His Glu 
            100                 105                 110         


Lys Tyr Glu Tyr Glu Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Gln 
        115                 120                 125             


Ser Ala 
    130 


<210>  38
<211>  130
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  38

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Arg His Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Ser Tyr Gly Ser Thr Asp Tyr Gly Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn Thr Val Pro Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Ala Asp Glu Thr Leu Gly Ala Val Pro Asn Phe Arg Leu His Glu 
            100                 105                 110         


Lys Tyr Glu Tyr Glu Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        115                 120                 125             


Ser Ala 
    130 


<210>  39
<211>  130
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  39

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Arg His Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Ser Tyr Gly Ser Thr Asp Tyr Gly Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn Thr Val Pro Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Ala Asp Glu Thr Leu Gly Ala Val Pro Asn Phe Arg Leu His Glu 
            100                 105                 110         


Lys Tyr Glu Tyr Glu Tyr Trp Gly Gln Gly Thr Leu Val Lys Val Ser 
        115                 120                 125             


Ser Ala 
    130 


<210>  40
<211>  130
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  40

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Arg His Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Ser Tyr Gly Ser Thr Asp Tyr Gly Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn Thr Val Pro Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Ala Asp Glu Thr Leu Gly Ala Val Pro Asn Phe Arg Leu His Glu 
            100                 105                 110         


Lys Tyr Glu Tyr Glu Tyr Trp Gly Gln Gly Thr Leu Val Gln Val Ser 
        115                 120                 125             


Ser Ala 
    130 


<210>  41
<211>  130
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  41

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Arg His Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Ser Tyr Gly Ser Thr Asp Tyr Gly Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn Thr Val Pro Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Ala Asp Glu Thr Leu Gly Ala Val Pro Asn Phe Arg Leu His Glu 
            100                 105                 110         


Lys Tyr Glu Tyr Glu Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Lys 
        115                 120                 125             


Ser Ala 
    130 


<210>  42
<211>  130
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  42

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Arg His Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Ser Tyr Gly Ser Thr Asp Tyr Gly Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn Thr Val Pro Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Ala Asp Glu Thr Leu Gly Ala Val Pro Asn Phe Arg Leu His Glu 
            100                 105                 110         


Lys Tyr Glu Tyr Glu Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Gln 
        115                 120                 125             


Ser Ala 
    130 


<210>  43
<211>  130
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  43

Glu Val Gln Leu Val Glu Ser Gly Gly Lys Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Arg Thr Phe Ser Phe Ser 
            20                  25                  30          


Thr Ser Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Leu Glu 
        35                  40                  45              


Phe Val Ala Ala Ile Asp Trp Ser Asp Phe Asn Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg His Asn Pro Arg Asn Ser 
65                  70                  75                  80  


Val Tyr Leu Gln Leu Asn Ser Leu Lys Pro Glu Asp Thr Ala Thr Tyr 
                85                  90                  95      


Tyr Cys Ala Ala His Ser Glu Thr Arg Gly Gly Thr Arg Tyr Phe Asp 
            100                 105                 110         


Arg Pro Ser Leu Tyr Asn Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
        115                 120                 125             


Ser Ser 
    130 


<210>  44
<211>  130
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  44

Glu Val Gln Leu Val Glu Ser Gly Gly Lys Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Arg Thr Phe Ser Phe Ser 
            20                  25                  30          


Thr Ser Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Leu Glu 
        35                  40                  45              


Phe Val Ala Ala Ile Asp Trp Ser Asp Phe Asn Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg His Asn Pro Arg Asn Ser 
65                  70                  75                  80  


Val Tyr Leu Gln Leu Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Ala His Ser Glu Thr Arg Gly Gly Thr Arg Tyr Phe Asp 
            100                 105                 110         


Arg Pro Ser Leu Tyr Asn Tyr Trp Gly Gln Gly Thr Leu Val Lys Val 
        115                 120                 125             


Ser Ser 
    130 


<210>  45
<211>  130
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  45

Glu Val Gln Leu Val Glu Ser Gly Gly Lys Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Arg Thr Phe Ser Phe Ser 
            20                  25                  30          


Thr Ser Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Leu Glu 
        35                  40                  45              


Phe Val Ala Ala Ile Asp Trp Ser Asp Phe Asn Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg His Asn Pro Arg Asn Ser 
65                  70                  75                  80  


Val Tyr Leu Gln Leu Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Ala His Ser Glu Thr Arg Gly Gly Thr Arg Tyr Phe Asp 
            100                 105                 110         


Arg Pro Ser Leu Tyr Asn Tyr Trp Gly Gln Gly Thr Leu Val Gln Val 
        115                 120                 125             


Ser Ser 
    130 


<210>  46
<211>  130
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  46

Glu Val Gln Leu Val Glu Ser Gly Gly Lys Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Arg Thr Phe Ser Phe Ser 
            20                  25                  30          


Thr Ser Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Leu Glu 
        35                  40                  45              


Phe Val Ala Ala Ile Asp Trp Ser Asp Phe Asn Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg His Asn Pro Arg Asn Ser 
65                  70                  75                  80  


Val Tyr Leu Gln Leu Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Ala His Ser Glu Thr Arg Gly Gly Thr Arg Tyr Phe Asp 
            100                 105                 110         


Arg Pro Ser Leu Tyr Asn Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
        115                 120                 125             


Lys Ser 
    130 


<210>  47
<211>  130
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  47

Glu Val Gln Leu Val Glu Ser Gly Gly Lys Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Arg Thr Phe Ser Phe Ser 
            20                  25                  30          


Thr Ser Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Leu Glu 
        35                  40                  45              


Phe Val Ala Ala Ile Asp Trp Ser Asp Phe Asn Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg His Asn Pro Arg Asn Ser 
65                  70                  75                  80  


Val Tyr Leu Gln Leu Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Ala His Ser Glu Thr Arg Gly Gly Thr Arg Tyr Phe Asp 
            100                 105                 110         


Arg Pro Ser Leu Tyr Asn Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
        115                 120                 125             


Gln Ser 
    130 


<210>  48
<211>  130
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  48

Glu Val Gln Leu Val Glu Ser Gly Gly Lys Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Arg Thr Phe Ser Phe Ser 
            20                  25                  30          


Thr Ser Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Leu Glu 
        35                  40                  45              


Phe Val Ala Ala Ile Asp Trp Ser Asp Phe Asn Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg His Asn Pro Arg Asn Ser 
65                  70                  75                  80  


Val Tyr Leu Gln Leu Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr 
                85                  90                  95      


Tyr Cys Ala Ala His Ser Glu Thr Arg Gly Gly Thr Arg Tyr Phe Asp 
            100                 105                 110         


Arg Pro Ser Leu Tyr Asn Tyr Trp Gly Gln Gly Thr Leu Val Lys Val 
        115                 120                 125             


Ser Ser 
    130 


<210>  49
<211>  130
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  49

Glu Val Gln Leu Val Glu Ser Gly Gly Lys Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Arg Thr Phe Ser Phe Ser 
            20                  25                  30          


Thr Ser Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Leu Glu 
        35                  40                  45              


Phe Val Ala Ala Ile Asp Trp Ser Asp Phe Asn Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg His Asn Pro Arg Asn Ser 
65                  70                  75                  80  


Val Tyr Leu Gln Leu Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr 
                85                  90                  95      


Tyr Cys Ala Ala His Ser Glu Thr Arg Gly Gly Thr Arg Tyr Phe Asp 
            100                 105                 110         


Arg Pro Ser Leu Tyr Asn Tyr Trp Gly Gln Gly Thr Leu Val Gln Val 
        115                 120                 125             


Ser Ser 
    130 


<210>  50
<211>  130
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  50

Glu Val Gln Leu Val Glu Ser Gly Gly Lys Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Arg Thr Phe Ser Phe Ser 
            20                  25                  30          


Thr Ser Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Leu Glu 
        35                  40                  45              


Phe Val Ala Ala Ile Asp Trp Ser Asp Phe Asn Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg His Asn Pro Arg Asn Ser 
65                  70                  75                  80  


Val Tyr Leu Gln Leu Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr 
                85                  90                  95      


Tyr Cys Ala Ala His Ser Glu Thr Arg Gly Gly Thr Arg Tyr Phe Asp 
            100                 105                 110         


Arg Pro Ser Leu Tyr Asn Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
        115                 120                 125             


Lys Ser 
    130 


<210>  51
<211>  130
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  51

Glu Val Gln Leu Val Glu Ser Gly Gly Lys Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Arg Thr Phe Ser Phe Ser 
            20                  25                  30          


Thr Ser Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Leu Glu 
        35                  40                  45              


Phe Val Ala Ala Ile Asp Trp Ser Asp Phe Asn Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg His Asn Pro Arg Asn Ser 
65                  70                  75                  80  


Val Tyr Leu Gln Leu Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr 
                85                  90                  95      


Tyr Cys Ala Ala His Ser Glu Thr Arg Gly Gly Thr Arg Tyr Phe Asp 
            100                 105                 110         


Arg Pro Ser Leu Tyr Asn Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
        115                 120                 125             


Gln Ser 
    130 


<210>  52
<211>  130
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  52

Glu Val Gln Leu Val Glu Ser Gly Gly Lys Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Arg Thr Phe Ser Phe Ser 
            20                  25                  30          


Thr Ser Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Leu Glu 
        35                  40                  45              


Phe Val Ala Ala Ile Asp Trp Ser Asp Phe Asn Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg His Asn Pro Arg Asn Ser 
65                  70                  75                  80  


Val Tyr Leu Gln Leu Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr 
                85                  90                  95      


Tyr Cys Ala Ala His Ser Glu Thr Arg Gly Gly Thr Arg Tyr Phe Asp 
            100                 105                 110         


Arg Pro Ser Leu Tyr Asn Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
        115                 120                 125             


Ser Ser 
    130 


<210>  53
<211>  130
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  53

Glu Val Gln Leu Val Glu Ser Gly Gly Lys Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Arg Thr Phe Ser Phe Ser 
            20                  25                  30          


Thr Ser Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Leu Glu 
        35                  40                  45              


Phe Val Ala Ala Ile Asp Trp Ser Asp Phe Asn Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg His Asn Pro Arg Asn Ser 
65                  70                  75                  80  


Val Tyr Leu Gln Leu Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr 
                85                  90                  95      


Tyr Cys Ala Ala His Ser Glu Thr Arg Gly Gly Thr Arg Tyr Phe Asp 
            100                 105                 110         


Arg Pro Ser Leu Tyr Asn Tyr Trp Gly Gln Gly Thr Leu Val Lys Val 
        115                 120                 125             


Ser Ser 
    130 


<210>  54
<211>  130
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  54

Glu Val Gln Leu Val Glu Ser Gly Gly Lys Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Arg Thr Phe Ser Phe Ser 
            20                  25                  30          


Thr Ser Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Leu Glu 
        35                  40                  45              


Phe Val Ala Ala Ile Asp Trp Ser Asp Phe Asn Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg His Asn Pro Arg Asn Ser 
65                  70                  75                  80  


Val Tyr Leu Gln Leu Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr 
                85                  90                  95      


Tyr Cys Ala Ala His Ser Glu Thr Arg Gly Gly Thr Arg Tyr Phe Asp 
            100                 105                 110         


Arg Pro Ser Leu Tyr Asn Tyr Trp Gly Gln Gly Thr Leu Val Gln Val 
        115                 120                 125             


Ser Ser 
    130 


<210>  55
<211>  130
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  55

Glu Val Gln Leu Val Glu Ser Gly Gly Lys Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Arg Thr Phe Ser Phe Ser 
            20                  25                  30          


Thr Ser Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Leu Glu 
        35                  40                  45              


Phe Val Ala Ala Ile Asp Trp Ser Asp Phe Asn Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg His Asn Pro Arg Asn Ser 
65                  70                  75                  80  


Val Tyr Leu Gln Leu Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr 
                85                  90                  95      


Tyr Cys Ala Ala His Ser Glu Thr Arg Gly Gly Thr Arg Tyr Phe Asp 
            100                 105                 110         


Arg Pro Ser Leu Tyr Asn Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
        115                 120                 125             


Lys Ser 
    130 


<210>  56
<211>  130
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  56

Glu Val Gln Leu Val Glu Ser Gly Gly Lys Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Arg Thr Phe Ser Phe Ser 
            20                  25                  30          


Thr Ser Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Leu Glu 
        35                  40                  45              


Phe Val Ala Ala Ile Asp Trp Ser Asp Phe Asn Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg His Asn Pro Arg Asn Ser 
65                  70                  75                  80  


Val Tyr Leu Gln Leu Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr 
                85                  90                  95      


Tyr Cys Ala Ala His Ser Glu Thr Arg Gly Gly Thr Arg Tyr Phe Asp 
            100                 105                 110         


Arg Pro Ser Leu Tyr Asn Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
        115                 120                 125             


Gln Ser 
    130 


<210>  57
<211>  131
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  57

Glu Val Gln Leu Val Glu Ser Gly Gly Lys Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Arg Thr Phe Ser Phe Ser 
            20                  25                  30          


Thr Ser Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Leu Glu 
        35                  40                  45              


Phe Val Ala Ala Ile Asp Trp Ser Asp Phe Asn Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg His Asn Pro Arg Asn Ser 
65                  70                  75                  80  


Val Tyr Leu Gln Leu Asn Ser Leu Lys Pro Glu Asp Thr Ala Thr Tyr 
                85                  90                  95      


Tyr Cys Ala Ala His Ser Glu Thr Arg Gly Gly Thr Arg Tyr Phe Asp 
            100                 105                 110         


Arg Pro Ser Leu Tyr Asn Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
        115                 120                 125             


Ser Ser Ala 
    130     


<210>  58
<211>  131
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  58

Glu Val Gln Leu Val Glu Ser Gly Gly Lys Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Arg Thr Phe Ser Phe Ser 
            20                  25                  30          


Thr Ser Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Leu Glu 
        35                  40                  45              


Phe Val Ala Ala Ile Asp Trp Ser Asp Phe Asn Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg His Asn Pro Arg Asn Ser 
65                  70                  75                  80  


Val Tyr Leu Gln Leu Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Ala His Ser Glu Thr Arg Gly Gly Thr Arg Tyr Phe Asp 
            100                 105                 110         


Arg Pro Ser Leu Tyr Asn Tyr Trp Gly Gln Gly Thr Leu Val Lys Val 
        115                 120                 125             


Ser Ser Ala 
    130     


<210>  59
<211>  131
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  59

Glu Val Gln Leu Val Glu Ser Gly Gly Lys Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Arg Thr Phe Ser Phe Ser 
            20                  25                  30          


Thr Ser Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Leu Glu 
        35                  40                  45              


Phe Val Ala Ala Ile Asp Trp Ser Asp Phe Asn Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg His Asn Pro Arg Asn Ser 
65                  70                  75                  80  


Val Tyr Leu Gln Leu Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Ala His Ser Glu Thr Arg Gly Gly Thr Arg Tyr Phe Asp 
            100                 105                 110         


Arg Pro Ser Leu Tyr Asn Tyr Trp Gly Gln Gly Thr Leu Val Gln Val 
        115                 120                 125             


Ser Ser Ala 
    130     


<210>  60
<211>  131
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  60

Glu Val Gln Leu Val Glu Ser Gly Gly Lys Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Arg Thr Phe Ser Phe Ser 
            20                  25                  30          


Thr Ser Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Leu Glu 
        35                  40                  45              


Phe Val Ala Ala Ile Asp Trp Ser Asp Phe Asn Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg His Asn Pro Arg Asn Ser 
65                  70                  75                  80  


Val Tyr Leu Gln Leu Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Ala His Ser Glu Thr Arg Gly Gly Thr Arg Tyr Phe Asp 
            100                 105                 110         


Arg Pro Ser Leu Tyr Asn Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
        115                 120                 125             


Lys Ser Ala 
    130     


<210>  61
<211>  131
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  61

Glu Val Gln Leu Val Glu Ser Gly Gly Lys Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Arg Thr Phe Ser Phe Ser 
            20                  25                  30          


Thr Ser Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Leu Glu 
        35                  40                  45              


Phe Val Ala Ala Ile Asp Trp Ser Asp Phe Asn Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg His Asn Pro Arg Asn Ser 
65                  70                  75                  80  


Val Tyr Leu Gln Leu Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Ala His Ser Glu Thr Arg Gly Gly Thr Arg Tyr Phe Asp 
            100                 105                 110         


Arg Pro Ser Leu Tyr Asn Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
        115                 120                 125             


Gln Ser Ala 
    130     


<210>  62
<211>  131
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  62

Glu Val Gln Leu Val Glu Ser Gly Gly Lys Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Arg Thr Phe Ser Phe Ser 
            20                  25                  30          


Thr Ser Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Leu Glu 
        35                  40                  45              


Phe Val Ala Ala Ile Asp Trp Ser Asp Phe Asn Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg His Asn Pro Arg Asn Ser 
65                  70                  75                  80  


Val Tyr Leu Gln Leu Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr 
                85                  90                  95      


Tyr Cys Ala Ala His Ser Glu Thr Arg Gly Gly Thr Arg Tyr Phe Asp 
            100                 105                 110         


Arg Pro Ser Leu Tyr Asn Tyr Trp Gly Gln Gly Thr Leu Val Lys Val 
        115                 120                 125             


Ser Ser Ala 
    130     


<210>  63
<211>  131
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  63

Glu Val Gln Leu Val Glu Ser Gly Gly Lys Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Arg Thr Phe Ser Phe Ser 
            20                  25                  30          


Thr Ser Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Leu Glu 
        35                  40                  45              


Phe Val Ala Ala Ile Asp Trp Ser Asp Phe Asn Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg His Asn Pro Arg Asn Ser 
65                  70                  75                  80  


Val Tyr Leu Gln Leu Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr 
                85                  90                  95      


Tyr Cys Ala Ala His Ser Glu Thr Arg Gly Gly Thr Arg Tyr Phe Asp 
            100                 105                 110         


Arg Pro Ser Leu Tyr Asn Tyr Trp Gly Gln Gly Thr Leu Val Gln Val 
        115                 120                 125             


Ser Ser Ala 
    130     


<210>  64
<211>  131
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  64

Glu Val Gln Leu Val Glu Ser Gly Gly Lys Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Arg Thr Phe Ser Phe Ser 
            20                  25                  30          


Thr Ser Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Leu Glu 
        35                  40                  45              


Phe Val Ala Ala Ile Asp Trp Ser Asp Phe Asn Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg His Asn Pro Arg Asn Ser 
65                  70                  75                  80  


Val Tyr Leu Gln Leu Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr 
                85                  90                  95      


Tyr Cys Ala Ala His Ser Glu Thr Arg Gly Gly Thr Arg Tyr Phe Asp 
            100                 105                 110         


Arg Pro Ser Leu Tyr Asn Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
        115                 120                 125             


Lys Ser Ala 
    130     


<210>  65
<211>  131
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  65

Glu Val Gln Leu Val Glu Ser Gly Gly Lys Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Arg Thr Phe Ser Phe Ser 
            20                  25                  30          


Thr Ser Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Leu Glu 
        35                  40                  45              


Phe Val Ala Ala Ile Asp Trp Ser Asp Phe Asn Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg His Asn Pro Arg Asn Ser 
65                  70                  75                  80  


Val Tyr Leu Gln Leu Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr 
                85                  90                  95      


Tyr Cys Ala Ala His Ser Glu Thr Arg Gly Gly Thr Arg Tyr Phe Asp 
            100                 105                 110         


Arg Pro Ser Leu Tyr Asn Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
        115                 120                 125             


Gln Ser Ala 
    130     


<210>  66
<211>  131
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  66

Glu Val Gln Leu Val Glu Ser Gly Gly Lys Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Arg Thr Phe Ser Phe Ser 
            20                  25                  30          


Thr Ser Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Leu Glu 
        35                  40                  45              


Phe Val Ala Ala Ile Asp Trp Ser Asp Phe Asn Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg His Asn Pro Arg Asn Ser 
65                  70                  75                  80  


Val Tyr Leu Gln Leu Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr 
                85                  90                  95      


Tyr Cys Ala Ala His Ser Glu Thr Arg Gly Gly Thr Arg Tyr Phe Asp 
            100                 105                 110         


Arg Pro Ser Leu Tyr Asn Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
        115                 120                 125             


Ser Ser Ala 
    130     


<210>  67
<211>  131
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  67

Glu Val Gln Leu Val Glu Ser Gly Gly Lys Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Arg Thr Phe Ser Phe Ser 
            20                  25                  30          


Thr Ser Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Leu Glu 
        35                  40                  45              


Phe Val Ala Ala Ile Asp Trp Ser Asp Phe Asn Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg His Asn Pro Arg Asn Ser 
65                  70                  75                  80  


Val Tyr Leu Gln Leu Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr 
                85                  90                  95      


Tyr Cys Ala Ala His Ser Glu Thr Arg Gly Gly Thr Arg Tyr Phe Asp 
            100                 105                 110         


Arg Pro Ser Leu Tyr Asn Tyr Trp Gly Gln Gly Thr Leu Val Lys Val 
        115                 120                 125             


Ser Ser Ala 
    130     


<210>  68
<211>  131
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  68

Glu Val Gln Leu Val Glu Ser Gly Gly Lys Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Arg Thr Phe Ser Phe Ser 
            20                  25                  30          


Thr Ser Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Leu Glu 
        35                  40                  45              


Phe Val Ala Ala Ile Asp Trp Ser Asp Phe Asn Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg His Asn Pro Arg Asn Ser 
65                  70                  75                  80  


Val Tyr Leu Gln Leu Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr 
                85                  90                  95      


Tyr Cys Ala Ala His Ser Glu Thr Arg Gly Gly Thr Arg Tyr Phe Asp 
            100                 105                 110         


Arg Pro Ser Leu Tyr Asn Tyr Trp Gly Gln Gly Thr Leu Val Gln Val 
        115                 120                 125             


Ser Ser Ala 
    130     


<210>  69
<211>  131
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  69

Glu Val Gln Leu Val Glu Ser Gly Gly Lys Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Arg Thr Phe Ser Phe Ser 
            20                  25                  30          


Thr Ser Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Leu Glu 
        35                  40                  45              


Phe Val Ala Ala Ile Asp Trp Ser Asp Phe Asn Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg His Asn Pro Arg Asn Ser 
65                  70                  75                  80  


Val Tyr Leu Gln Leu Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr 
                85                  90                  95      


Tyr Cys Ala Ala His Ser Glu Thr Arg Gly Gly Thr Arg Tyr Phe Asp 
            100                 105                 110         


Arg Pro Ser Leu Tyr Asn Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
        115                 120                 125             


Lys Ser Ala 
    130     


<210>  70
<211>  131
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  70

Glu Val Gln Leu Val Glu Ser Gly Gly Lys Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Arg Thr Phe Ser Phe Ser 
            20                  25                  30          


Thr Ser Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Leu Glu 
        35                  40                  45              


Phe Val Ala Ala Ile Asp Trp Ser Asp Phe Asn Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg His Asn Pro Arg Asn Ser 
65                  70                  75                  80  


Val Tyr Leu Gln Leu Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr 
                85                  90                  95      


Tyr Cys Ala Ala His Ser Glu Thr Arg Gly Gly Thr Arg Tyr Phe Asp 
            100                 105                 110         


Arg Pro Ser Leu Tyr Asn Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
        115                 120                 125             


Gln Ser Ala 
    130     


<210>  71
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HIS6-FLAG3 tag

<400>  71

His His His His His His Gly Ala Ala Asp Tyr Lys Asp His Asp Gly 
1               5                   10                  15      


Asp Tyr Lys Asp His Asp Ile Asp Tyr Lys Asp Asp Asp Asp Lys Gly 
            20                  25                  30          


Ala Ala 
        


<210>  72
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-terminal end

<400>  72

Val Thr Val Lys Ser 
1               5   


<210>  73
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-terminal end

<400>  73

Val Thr Val Gln Ser 
1               5   


<210>  74
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-terminal end

<400>  74

Val Lys Val Ser Ser 
1               5   


<210>  75
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-terminal end

<400>  75

Val Gln Val Ser Ser 
1               5   


<210>  76
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-terminal end


<220>
<221>  SITE
<222>  (6)..(6)
<223>  Xaa stands for (X)n which means C-terminal extension with n amino
       acids, wherein each position is chosen independently from any 
       amino acids

<400>  76

Val Thr Val Lys Ser Xaa 
1               5       


<210>  77
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-terminal end


<220>
<221>  SITE
<222>  (6)..(6)
<223>  Xaa stands for (X)n which means C-terminal extension with n amino
       acids, wherein each position is chosen independently from any 
       amino acids

<400>  77

Val Thr Val Gln Ser Xaa 
1               5       


<210>  78
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-terminal end


<220>
<221>  SITE
<222>  (6)..(6)
<223>  Xaa stands for (X)n which means C-terminal extension with n amino
       acids, wherein each position is chosen independently from any 
       amino acids

<400>  78

Val Lys Val Ser Ser Xaa 
1               5       


<210>  79
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-terminal end


<220>
<221>  SITE
<222>  (6)..(6)
<223>  Xaa stands for (X)n which means C-terminal extension with n amino
       acids, wherein each position is chosen independently from any 
       amino acids

<400>  79

Val Gln Val Ser Ser Xaa 
1               5       


<210>  80
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-terminal end

<400>  80

Val Thr Val Lys Ser Ala 
1               5       


<210>  81
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-terminal end

<400>  81

Val Thr Val Gln Ser Ala 
1               5       


<210>  82
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-terminal end

<400>  82

Val Lys Val Ser Ser Ala 
1               5       


<210>  83
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-terminal end

<400>  83

Val Gln Val Ser Ser Ala 
1               5       


<210>  84
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-terminal end

<400>  84

Val Thr Val Ser Ser 
1               5   


<210>  85
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-terminal end


<220>
<221>  SITE
<222>  (6)..(6)
<223>  Xaa stands for (X)n which means C-terminal extension with n amino
       acids, wherein each position is chosen independently from any 
       amino acids

<400>  85

Val Thr Val Ser Ser Xaa 
1               5       


<210>  86
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-terminal end

<400>  86

Thr Val Thr Ser Ser Ala 
1               5       


<210>  87
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  87

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Arg His Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Ser Tyr Gly Ser Thr Asp Tyr Gly Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn Thr Val Pro Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Ala Asp Glu Thr Leu Gly Ala Val Pro Asn Phe Arg Leu His Glu 
            100                 105                 110         


Lys Tyr Glu Tyr Glu Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  88
<211>  130
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  88

Glu Val Gln Leu Val Glu Ser Gly Gly Lys Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Arg Thr Phe Ser Phe Ser 
            20                  25                  30          


Thr Ser Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Leu Glu 
        35                  40                  45              


Phe Val Ala Ala Ile Asp Trp Ser Asp Phe Asn Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg His Asn Pro Arg Asn Ser 
65                  70                  75                  80  


Val Tyr Leu Gln Leu Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Ala His Ser Glu Thr Arg Gly Gly Thr Arg Tyr Phe Asp 
            100                 105                 110         


Arg Pro Ser Leu Tyr Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val 
        115                 120                 125             


Ser Ser 
    130 


<210>  89
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  89

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Asn 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  90
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  90

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Asn 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  91
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  91

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Asn 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Lys 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  92
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  92

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Ser Phe 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  93
<211>  417
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  93

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Arg His Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Ser Tyr Gly Ser Thr Asp Tyr Gly Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn Thr Val Pro Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Ala Asp Glu Thr Leu Gly Ala Val Pro Asn Phe Arg Leu His Glu 
            100                 105                 110         


Lys Tyr Glu Tyr Glu Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
145                 150                 155                 160 


Gly Gly Gly Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln 
                165                 170                 175     


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe 
            180                 185                 190         


Arg His Tyr Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg 
        195                 200                 205             


Glu Phe Val Ala Ala Ile Ser Ser Tyr Gly Ser Thr Asp Tyr Gly Asp 
    210                 215                 220                 


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn Thr 
225                 230                 235                 240 


Val Pro Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr 
                245                 250                 255     


Tyr Cys Ala Ala Ala Asp Glu Thr Leu Gly Ala Val Pro Asn Phe Arg 
            260                 265                 270         


Leu His Glu Lys Tyr Glu Tyr Glu Tyr Trp Gly Gln Gly Thr Leu Val 
        275                 280                 285             


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln 
    290                 295                 300                 


Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Asn Ser Leu Arg 
305                 310                 315                 320 


Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe Gly Met Ser 
                325                 330                 335     


Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser Ile 
            340                 345                 350         


Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val Lys Gly Arg 
        355                 360                 365             


Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr Leu Gln Met 
    370                 375                 380                 


Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Thr Ile Gly 
385                 390                 395                 400 


Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr Val Ser Ser 
                405                 410                 415     


Ala 
    


<210>  94
<211>  417
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  94

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Arg His Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Ser Tyr Gly Ser Thr Asp Tyr Gly Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn Thr Val Pro Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Ala Asp Glu Thr Leu Gly Ala Val Pro Asn Phe Arg Leu His Glu 
            100                 105                 110         


Lys Tyr Glu Tyr Glu Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
145                 150                 155                 160 


Gly Gly Gly Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln 
                165                 170                 175     


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe 
            180                 185                 190         


Arg His Tyr Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg 
        195                 200                 205             


Glu Phe Val Ala Ala Ile Ser Ser Tyr Gly Ser Thr Asp Tyr Gly Asp 
    210                 215                 220                 


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn Thr 
225                 230                 235                 240 


Val Pro Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr 
                245                 250                 255     


Tyr Cys Ala Ala Ala Asp Glu Thr Leu Gly Ala Val Pro Asn Phe Arg 
            260                 265                 270         


Leu His Glu Lys Tyr Glu Tyr Glu Tyr Trp Gly Gln Gly Thr Leu Val 
        275                 280                 285             


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln 
    290                 295                 300                 


Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Asn Ser Leu Arg 
305                 310                 315                 320 


Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe Gly Met Ser 
                325                 330                 335     


Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser Ile 
            340                 345                 350         


Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val Lys Gly Arg 
        355                 360                 365             


Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr Leu Gln Met 
    370                 375                 380                 


Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Thr Ile Gly 
385                 390                 395                 400 


Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr Val Ser Ser 
                405                 410                 415     


Ala 
    


<210>  95
<211>  417
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  95

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Arg His Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Ser Tyr Gly Ser Thr Asp Tyr Gly Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn Thr Val Pro Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Ala Asp Glu Thr Leu Gly Ala Val Pro Asn Phe Arg Leu His Glu 
            100                 105                 110         


Lys Tyr Glu Tyr Glu Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
145                 150                 155                 160 


Gly Gly Gly Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln 
                165                 170                 175     


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe 
            180                 185                 190         


Arg His Tyr Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg 
        195                 200                 205             


Glu Phe Val Ala Ala Ile Ser Ser Tyr Gly Ser Thr Asp Tyr Gly Asp 
    210                 215                 220                 


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn Thr 
225                 230                 235                 240 


Val Pro Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr 
                245                 250                 255     


Tyr Cys Ala Ala Ala Asp Glu Thr Leu Gly Ala Val Pro Asn Phe Arg 
            260                 265                 270         


Leu His Glu Lys Tyr Glu Tyr Glu Tyr Trp Gly Gln Gly Thr Leu Val 
        275                 280                 285             


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln 
    290                 295                 300                 


Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Asn Ser Leu Arg 
305                 310                 315                 320 


Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe Gly Met Ser 
                325                 330                 335     


Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser Ile 
            340                 345                 350         


Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val Lys Gly Arg 
        355                 360                 365             


Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr Leu Gln Met 
    370                 375                 380                 


Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Thr Ile Gly 
385                 390                 395                 400 


Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Lys Val Ser Ser 
                405                 410                 415     


Ala 
    


<210>  96
<211>  417
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  96

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Arg His Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Ser Tyr Gly Ser Thr Asp Tyr Gly Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn Thr Val Pro Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Ala Asp Glu Thr Leu Gly Ala Val Pro Asn Phe Arg Leu His Glu 
            100                 105                 110         


Lys Tyr Glu Tyr Glu Tyr Trp Gly Gln Gly Thr Leu Val Lys Val Ser 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
145                 150                 155                 160 


Gly Gly Gly Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln 
                165                 170                 175     


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe 
            180                 185                 190         


Arg His Tyr Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg 
        195                 200                 205             


Glu Phe Val Ala Ala Ile Ser Ser Tyr Gly Ser Thr Asp Tyr Gly Asp 
    210                 215                 220                 


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn Thr 
225                 230                 235                 240 


Val Pro Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr 
                245                 250                 255     


Tyr Cys Ala Ala Ala Asp Glu Thr Leu Gly Ala Val Pro Asn Phe Arg 
            260                 265                 270         


Leu His Glu Lys Tyr Glu Tyr Glu Tyr Trp Gly Gln Gly Thr Leu Val 
        275                 280                 285             


Lys Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln 
    290                 295                 300                 


Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Asn Ser Leu Arg 
305                 310                 315                 320 


Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe Gly Met Ser 
                325                 330                 335     


Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser Ile 
            340                 345                 350         


Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val Lys Gly Arg 
        355                 360                 365             


Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr Leu Gln Met 
    370                 375                 380                 


Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Thr Ile Gly 
385                 390                 395                 400 


Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr Val Ser Ser 
                405                 410                 415     


Ala 
    


<210>  97
<211>  417
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  97

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Arg His Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Ser Tyr Gly Ser Thr Asp Tyr Gly Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn Thr Val Pro Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Ala Asp Glu Thr Leu Gly Ala Val Pro Asn Phe Arg Leu His Glu 
            100                 105                 110         


Lys Tyr Glu Tyr Glu Tyr Trp Gly Gln Gly Thr Leu Val Lys Val Ser 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
145                 150                 155                 160 


Gly Gly Gly Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln 
                165                 170                 175     


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe 
            180                 185                 190         


Arg His Tyr Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg 
        195                 200                 205             


Glu Phe Val Ala Ala Ile Ser Ser Tyr Gly Ser Thr Asp Tyr Gly Asp 
    210                 215                 220                 


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn Thr 
225                 230                 235                 240 


Val Pro Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr 
                245                 250                 255     


Tyr Cys Ala Ala Ala Asp Glu Thr Leu Gly Ala Val Pro Asn Phe Arg 
            260                 265                 270         


Leu His Glu Lys Tyr Glu Tyr Glu Tyr Trp Gly Gln Gly Thr Leu Val 
        275                 280                 285             


Lys Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln 
    290                 295                 300                 


Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Asn Ser Leu Arg 
305                 310                 315                 320 


Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe Gly Met Ser 
                325                 330                 335     


Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser Ile 
            340                 345                 350         


Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val Lys Gly Arg 
        355                 360                 365             


Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr Leu Gln Met 
    370                 375                 380                 


Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Thr Ile Gly 
385                 390                 395                 400 


Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr Val Ser Ser 
                405                 410                 415     


Ala 
    


<210>  98
<211>  417
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  98

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Arg His Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Ser Tyr Gly Ser Thr Asp Tyr Gly Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn Thr Val Pro Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Ala Asp Glu Thr Leu Gly Ala Val Pro Asn Phe Arg Leu His Glu 
            100                 105                 110         


Lys Tyr Glu Tyr Glu Tyr Trp Gly Gln Gly Thr Leu Val Lys Val Ser 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
145                 150                 155                 160 


Gly Gly Gly Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln 
                165                 170                 175     


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe 
            180                 185                 190         


Arg His Tyr Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg 
        195                 200                 205             


Glu Phe Val Ala Ala Ile Ser Ser Tyr Gly Ser Thr Asp Tyr Gly Asp 
    210                 215                 220                 


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn Thr 
225                 230                 235                 240 


Val Pro Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr 
                245                 250                 255     


Tyr Cys Ala Ala Ala Asp Glu Thr Leu Gly Ala Val Pro Asn Phe Arg 
            260                 265                 270         


Leu His Glu Lys Tyr Glu Tyr Glu Tyr Trp Gly Gln Gly Thr Leu Val 
        275                 280                 285             


Lys Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln 
    290                 295                 300                 


Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Asn Ser Leu Arg 
305                 310                 315                 320 


Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe Gly Met Ser 
                325                 330                 335     


Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser Ile 
            340                 345                 350         


Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val Lys Gly Arg 
        355                 360                 365             


Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr Leu Gln Met 
    370                 375                 380                 


Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Thr Ile Gly 
385                 390                 395                 400 


Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Lys Val Ser Ser 
                405                 410                 415     


Ala 
    


<210>  99
<211>  419
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  99

Asp Val Gln Leu Val Glu Ser Gly Gly Lys Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Arg Thr Phe Ser Phe Ser 
            20                  25                  30          


Thr Ser Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Leu Glu 
        35                  40                  45              


Phe Val Ala Ala Ile Asp Trp Ser Asp Phe Asn Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg His Asn Pro Arg Asn Ser 
65                  70                  75                  80  


Val Tyr Leu Gln Leu Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr 
                85                  90                  95      


Tyr Cys Ala Ala His Ser Glu Thr Arg Gly Gly Thr Arg Tyr Phe Asp 
            100                 105                 110         


Arg Pro Ser Leu Tyr Asn Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
        115                 120                 125             


Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
145                 150                 155                 160 


Gly Gly Gly Gly Glu Val Gln Leu Val Glu Ser Gly Gly Lys Val Val 
                165                 170                 175     


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Arg Thr 
            180                 185                 190         


Phe Ser Phe Ser Thr Ser Thr Met Gly Trp Phe Arg Gln Ala Pro Gly 
        195                 200                 205             


Lys Glu Leu Glu Phe Val Ala Ala Ile Asp Trp Ser Asp Phe Asn Thr 
    210                 215                 220                 


Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg His Asn 
225                 230                 235                 240 


Pro Arg Asn Ser Val Tyr Leu Gln Leu Asn Ser Leu Lys Pro Glu Asp 
                245                 250                 255     


Thr Ala Leu Tyr Tyr Cys Ala Ala His Ser Glu Thr Arg Gly Gly Thr 
            260                 265                 270         


Arg Tyr Phe Asp Arg Pro Ser Leu Tyr Asn Tyr Trp Gly Gln Gly Thr 
        275                 280                 285             


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu 
    290                 295                 300                 


Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Asn Ser 
305                 310                 315                 320 


Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe Gly 
                325                 330                 335     


Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser 
            340                 345                 350         


Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val Lys 
        355                 360                 365             


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr Leu 
    370                 375                 380                 


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Thr 
385                 390                 395                 400 


Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr Val 
                405                 410                 415     


Ser Ser Ala 
            


<210>  100
<211>  419
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  100

Asp Val Gln Leu Val Glu Ser Gly Gly Lys Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Arg Thr Phe Ser Phe Ser 
            20                  25                  30          


Thr Ser Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Leu Glu 
        35                  40                  45              


Phe Val Ala Ala Ile Asp Trp Ser Asp Phe Asn Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg His Asn Pro Arg Asn Ser 
65                  70                  75                  80  


Val Tyr Leu Gln Leu Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr 
                85                  90                  95      


Tyr Cys Ala Ala His Ser Glu Thr Arg Gly Gly Thr Arg Tyr Phe Asp 
            100                 105                 110         


Arg Pro Ser Leu Tyr Asn Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
        115                 120                 125             


Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
145                 150                 155                 160 


Gly Gly Gly Gly Glu Val Gln Leu Val Glu Ser Gly Gly Lys Val Val 
                165                 170                 175     


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Arg Thr 
            180                 185                 190         


Phe Ser Phe Ser Thr Ser Thr Met Gly Trp Phe Arg Gln Ala Pro Gly 
        195                 200                 205             


Lys Glu Leu Glu Phe Val Ala Ala Ile Asp Trp Ser Asp Phe Asn Thr 
    210                 215                 220                 


Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg His Asn 
225                 230                 235                 240 


Pro Arg Asn Ser Val Tyr Leu Gln Leu Asn Ser Leu Lys Pro Glu Asp 
                245                 250                 255     


Thr Ala Leu Tyr Tyr Cys Ala Ala His Ser Glu Thr Arg Gly Gly Thr 
            260                 265                 270         


Arg Tyr Phe Asp Arg Pro Ser Leu Tyr Asn Tyr Trp Gly Gln Gly Thr 
        275                 280                 285             


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu 
    290                 295                 300                 


Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Asn Ser 
305                 310                 315                 320 


Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe Gly 
                325                 330                 335     


Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser 
            340                 345                 350         


Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val Lys 
        355                 360                 365             


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr Leu 
    370                 375                 380                 


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Thr 
385                 390                 395                 400 


Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr Val 
                405                 410                 415     


Ser Ser Ala 
            


<210>  101
<211>  419
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  101

Asp Val Gln Leu Val Glu Ser Gly Gly Lys Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Arg Thr Phe Ser Phe Ser 
            20                  25                  30          


Thr Ser Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Leu Glu 
        35                  40                  45              


Phe Val Ala Ala Ile Asp Trp Ser Asp Phe Asn Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg His Asn Pro Arg Asn Ser 
65                  70                  75                  80  


Val Tyr Leu Gln Leu Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr 
                85                  90                  95      


Tyr Cys Ala Ala His Ser Glu Thr Arg Gly Gly Thr Arg Tyr Phe Asp 
            100                 105                 110         


Arg Pro Ser Leu Tyr Asn Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
        115                 120                 125             


Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
145                 150                 155                 160 


Gly Gly Gly Gly Glu Val Gln Leu Val Glu Ser Gly Gly Lys Val Val 
                165                 170                 175     


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Arg Thr 
            180                 185                 190         


Phe Ser Phe Ser Thr Ser Thr Met Gly Trp Phe Arg Gln Ala Pro Gly 
        195                 200                 205             


Lys Glu Leu Glu Phe Val Ala Ala Ile Asp Trp Ser Asp Phe Asn Thr 
    210                 215                 220                 


Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg His Asn 
225                 230                 235                 240 


Pro Arg Asn Ser Val Tyr Leu Gln Leu Asn Ser Leu Lys Pro Glu Asp 
                245                 250                 255     


Thr Ala Leu Tyr Tyr Cys Ala Ala His Ser Glu Thr Arg Gly Gly Thr 
            260                 265                 270         


Arg Tyr Phe Asp Arg Pro Ser Leu Tyr Asn Tyr Trp Gly Gln Gly Thr 
        275                 280                 285             


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu 
    290                 295                 300                 


Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Asn Ser 
305                 310                 315                 320 


Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe Gly 
                325                 330                 335     


Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser 
            340                 345                 350         


Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val Lys 
        355                 360                 365             


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr Leu 
    370                 375                 380                 


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Thr 
385                 390                 395                 400 


Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Lys Val 
                405                 410                 415     


Ser Ser Ala 
            


<210>  102
<211>  419
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  102

Asp Val Gln Leu Val Glu Ser Gly Gly Lys Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Arg Thr Phe Ser Phe Ser 
            20                  25                  30          


Thr Ser Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Leu Glu 
        35                  40                  45              


Phe Val Ala Ala Ile Asp Trp Ser Asp Phe Asn Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg His Asn Pro Arg Asn Ser 
65                  70                  75                  80  


Val Tyr Leu Gln Leu Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr 
                85                  90                  95      


Tyr Cys Ala Ala His Ser Glu Thr Arg Gly Gly Thr Arg Tyr Phe Asp 
            100                 105                 110         


Arg Pro Ser Leu Tyr Asn Tyr Trp Gly Gln Gly Thr Leu Val Lys Val 
        115                 120                 125             


Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
145                 150                 155                 160 


Gly Gly Gly Gly Glu Val Gln Leu Val Glu Ser Gly Gly Lys Val Val 
                165                 170                 175     


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Arg Thr 
            180                 185                 190         


Phe Ser Phe Ser Thr Ser Thr Met Gly Trp Phe Arg Gln Ala Pro Gly 
        195                 200                 205             


Lys Glu Leu Glu Phe Val Ala Ala Ile Asp Trp Ser Asp Phe Asn Thr 
    210                 215                 220                 


Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg His Asn 
225                 230                 235                 240 


Pro Arg Asn Ser Val Tyr Leu Gln Leu Asn Ser Leu Lys Pro Glu Asp 
                245                 250                 255     


Thr Ala Leu Tyr Tyr Cys Ala Ala His Ser Glu Thr Arg Gly Gly Thr 
            260                 265                 270         


Arg Tyr Phe Asp Arg Pro Ser Leu Tyr Asn Tyr Trp Gly Gln Gly Thr 
        275                 280                 285             


Leu Val Lys Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu 
    290                 295                 300                 


Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Asn Ser 
305                 310                 315                 320 


Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe Gly 
                325                 330                 335     


Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser 
            340                 345                 350         


Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val Lys 
        355                 360                 365             


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr Leu 
    370                 375                 380                 


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Thr 
385                 390                 395                 400 


Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr Val 
                405                 410                 415     


Ser Ser Ala 
            


<210>  103
<211>  419
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  103

Asp Val Gln Leu Val Glu Ser Gly Gly Lys Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Arg Thr Phe Ser Phe Ser 
            20                  25                  30          


Thr Ser Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Leu Glu 
        35                  40                  45              


Phe Val Ala Ala Ile Asp Trp Ser Asp Phe Asn Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg His Asn Pro Arg Asn Ser 
65                  70                  75                  80  


Val Tyr Leu Gln Leu Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr 
                85                  90                  95      


Tyr Cys Ala Ala His Ser Glu Thr Arg Gly Gly Thr Arg Tyr Phe Asp 
            100                 105                 110         


Arg Pro Ser Leu Tyr Asn Tyr Trp Gly Gln Gly Thr Leu Val Lys Val 
        115                 120                 125             


Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
145                 150                 155                 160 


Gly Gly Gly Gly Glu Val Gln Leu Val Glu Ser Gly Gly Lys Val Val 
                165                 170                 175     


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Arg Thr 
            180                 185                 190         


Phe Ser Phe Ser Thr Ser Thr Met Gly Trp Phe Arg Gln Ala Pro Gly 
        195                 200                 205             


Lys Glu Leu Glu Phe Val Ala Ala Ile Asp Trp Ser Asp Phe Asn Thr 
    210                 215                 220                 


Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg His Asn 
225                 230                 235                 240 


Pro Arg Asn Ser Val Tyr Leu Gln Leu Asn Ser Leu Lys Pro Glu Asp 
                245                 250                 255     


Thr Ala Leu Tyr Tyr Cys Ala Ala His Ser Glu Thr Arg Gly Gly Thr 
            260                 265                 270         


Arg Tyr Phe Asp Arg Pro Ser Leu Tyr Asn Tyr Trp Gly Gln Gly Thr 
        275                 280                 285             


Leu Val Lys Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu 
    290                 295                 300                 


Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Asn Ser 
305                 310                 315                 320 


Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe Gly 
                325                 330                 335     


Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser 
            340                 345                 350         


Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val Lys 
        355                 360                 365             


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr Leu 
    370                 375                 380                 


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Thr 
385                 390                 395                 400 


Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr Val 
                405                 410                 415     


Ser Ser Ala 
            


<210>  104
<211>  419
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  104

Asp Val Gln Leu Val Glu Ser Gly Gly Lys Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Arg Thr Phe Ser Phe Ser 
            20                  25                  30          


Thr Ser Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Leu Glu 
        35                  40                  45              


Phe Val Ala Ala Ile Asp Trp Ser Asp Phe Asn Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg His Asn Pro Arg Asn Ser 
65                  70                  75                  80  


Val Tyr Leu Gln Leu Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr 
                85                  90                  95      


Tyr Cys Ala Ala His Ser Glu Thr Arg Gly Gly Thr Arg Tyr Phe Asp 
            100                 105                 110         


Arg Pro Ser Leu Tyr Asn Tyr Trp Gly Gln Gly Thr Leu Val Lys Val 
        115                 120                 125             


Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
145                 150                 155                 160 


Gly Gly Gly Gly Glu Val Gln Leu Val Glu Ser Gly Gly Lys Val Val 
                165                 170                 175     


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Arg Thr 
            180                 185                 190         


Phe Ser Phe Ser Thr Ser Thr Met Gly Trp Phe Arg Gln Ala Pro Gly 
        195                 200                 205             


Lys Glu Leu Glu Phe Val Ala Ala Ile Asp Trp Ser Asp Phe Asn Thr 
    210                 215                 220                 


Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg His Asn 
225                 230                 235                 240 


Pro Arg Asn Ser Val Tyr Leu Gln Leu Asn Ser Leu Lys Pro Glu Asp 
                245                 250                 255     


Thr Ala Leu Tyr Tyr Cys Ala Ala His Ser Glu Thr Arg Gly Gly Thr 
            260                 265                 270         


Arg Tyr Phe Asp Arg Pro Ser Leu Tyr Asn Tyr Trp Gly Gln Gly Thr 
        275                 280                 285             


Leu Val Lys Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu 
    290                 295                 300                 


Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Asn Ser 
305                 310                 315                 320 


Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe Gly 
                325                 330                 335     


Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser 
            340                 345                 350         


Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val Lys 
        355                 360                 365             


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr Leu 
    370                 375                 380                 


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Thr 
385                 390                 395                 400 


Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Lys Val 
                405                 410                 415     


Ser Ser Ala 
            


<210>  105
<211>  418
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  105

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Arg His Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Ser Tyr Gly Ser Thr Asp Tyr Gly Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn Thr Val Pro Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Ala Asp Glu Thr Leu Gly Ala Val Pro Asn Phe Arg Leu His Glu 
            100                 105                 110         


Lys Tyr Glu Tyr Glu Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
145                 150                 155                 160 


Gly Gly Gly Glu Val Gln Leu Val Glu Ser Gly Gly Lys Val Val Gln 
                165                 170                 175     


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Arg Thr Phe 
            180                 185                 190         


Ser Phe Ser Thr Ser Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys 
        195                 200                 205             


Glu Leu Glu Phe Val Ala Ala Ile Asp Trp Ser Asp Phe Asn Thr Tyr 
    210                 215                 220                 


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg His Asn Pro 
225                 230                 235                 240 


Arg Asn Ser Val Tyr Leu Gln Leu Asn Ser Leu Lys Pro Glu Asp Thr 
                245                 250                 255     


Ala Leu Tyr Tyr Cys Ala Ala His Ser Glu Thr Arg Gly Gly Thr Arg 
            260                 265                 270         


Tyr Phe Asp Arg Pro Ser Leu Tyr Asn Tyr Trp Gly Gln Gly Thr Leu 
        275                 280                 285             


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val 
    290                 295                 300                 


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Asn Ser Leu 
305                 310                 315                 320 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe Gly Met 
                325                 330                 335     


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser 
            340                 345                 350         


Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val Lys Gly 
        355                 360                 365             


Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr Leu Gln 
    370                 375                 380                 


Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Thr Ile 
385                 390                 395                 400 


Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr Val Ser 
                405                 410                 415     


Ser Ala 
        


<210>  106
<211>  418
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  106

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Arg His Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Ser Tyr Gly Ser Thr Asp Tyr Gly Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn Thr Val Pro Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Ala Asp Glu Thr Leu Gly Ala Val Pro Asn Phe Arg Leu His Glu 
            100                 105                 110         


Lys Tyr Glu Tyr Glu Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
145                 150                 155                 160 


Gly Gly Gly Glu Val Gln Leu Val Glu Ser Gly Gly Lys Val Val Gln 
                165                 170                 175     


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Arg Thr Phe 
            180                 185                 190         


Ser Phe Ser Thr Ser Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys 
        195                 200                 205             


Glu Leu Glu Phe Val Ala Ala Ile Asp Trp Ser Asp Phe Asn Thr Tyr 
    210                 215                 220                 


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg His Asn Pro 
225                 230                 235                 240 


Arg Asn Ser Val Tyr Leu Gln Leu Asn Ser Leu Lys Pro Glu Asp Thr 
                245                 250                 255     


Ala Leu Tyr Tyr Cys Ala Ala His Ser Glu Thr Arg Gly Gly Thr Arg 
            260                 265                 270         


Tyr Phe Asp Arg Pro Ser Leu Tyr Asn Tyr Trp Gly Gln Gly Thr Leu 
        275                 280                 285             


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val 
    290                 295                 300                 


Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Asn Ser Leu 
305                 310                 315                 320 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe Gly Met 
                325                 330                 335     


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser 
            340                 345                 350         


Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val Lys Gly 
        355                 360                 365             


Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr Leu Gln 
    370                 375                 380                 


Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Thr Ile 
385                 390                 395                 400 


Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr Val Ser 
                405                 410                 415     


Ser Ala 
        


<210>  107
<211>  418
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  107

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Arg His Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Ser Tyr Gly Ser Thr Asp Tyr Gly Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn Thr Val Pro Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Ala Asp Glu Thr Leu Gly Ala Val Pro Asn Phe Arg Leu His Glu 
            100                 105                 110         


Lys Tyr Glu Tyr Glu Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
145                 150                 155                 160 


Gly Gly Gly Glu Val Gln Leu Val Glu Ser Gly Gly Lys Val Val Gln 
                165                 170                 175     


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Arg Thr Phe 
            180                 185                 190         


Ser Phe Ser Thr Ser Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys 
        195                 200                 205             


Glu Leu Glu Phe Val Ala Ala Ile Asp Trp Ser Asp Phe Asn Thr Tyr 
    210                 215                 220                 


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg His Asn Pro 
225                 230                 235                 240 


Arg Asn Ser Val Tyr Leu Gln Leu Asn Ser Leu Lys Pro Glu Asp Thr 
                245                 250                 255     


Ala Leu Tyr Tyr Cys Ala Ala His Ser Glu Thr Arg Gly Gly Thr Arg 
            260                 265                 270         


Tyr Phe Asp Arg Pro Ser Leu Tyr Asn Tyr Trp Gly Gln Gly Thr Leu 
        275                 280                 285             


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val 
    290                 295                 300                 


Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Asn Ser Leu 
305                 310                 315                 320 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe Gly Met 
                325                 330                 335     


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser 
            340                 345                 350         


Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val Lys Gly 
        355                 360                 365             


Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr Leu Gln 
    370                 375                 380                 


Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Thr Ile 
385                 390                 395                 400 


Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Lys Val Ser 
                405                 410                 415     


Ser Ala 
        


<210>  108
<211>  418
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  108

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Arg His Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Ser Tyr Gly Ser Thr Asp Tyr Gly Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn Thr Val Pro Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Ala Asp Glu Thr Leu Gly Ala Val Pro Asn Phe Arg Leu His Glu 
            100                 105                 110         


Lys Tyr Glu Tyr Glu Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
145                 150                 155                 160 


Gly Gly Gly Glu Val Gln Leu Val Glu Ser Gly Gly Lys Val Val Gln 
                165                 170                 175     


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Arg Thr Phe 
            180                 185                 190         


Ser Phe Ser Thr Ser Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys 
        195                 200                 205             


Glu Leu Glu Phe Val Ala Ala Ile Asp Trp Ser Asp Phe Asn Thr Tyr 
    210                 215                 220                 


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg His Asn Pro 
225                 230                 235                 240 


Arg Asn Ser Val Tyr Leu Gln Leu Asn Ser Leu Lys Pro Glu Asp Thr 
                245                 250                 255     


Ala Leu Tyr Tyr Cys Ala Ala His Ser Glu Thr Arg Gly Gly Thr Arg 
            260                 265                 270         


Tyr Phe Asp Arg Pro Ser Leu Tyr Asn Tyr Trp Gly Gln Gly Thr Leu 
        275                 280                 285             


Val Lys Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val 
    290                 295                 300                 


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Asn Ser Leu 
305                 310                 315                 320 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe Gly Met 
                325                 330                 335     


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser 
            340                 345                 350         


Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val Lys Gly 
        355                 360                 365             


Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr Leu Gln 
    370                 375                 380                 


Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Thr Ile 
385                 390                 395                 400 


Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr Val Ser 
                405                 410                 415     


Ser Ala 
        


<210>  109
<211>  418
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  109

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Arg His Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Ser Tyr Gly Ser Thr Asp Tyr Gly Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn Thr Val Pro Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Ala Asp Glu Thr Leu Gly Ala Val Pro Asn Phe Arg Leu His Glu 
            100                 105                 110         


Lys Tyr Glu Tyr Glu Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
145                 150                 155                 160 


Gly Gly Gly Glu Val Gln Leu Val Glu Ser Gly Gly Lys Val Val Gln 
                165                 170                 175     


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Arg Thr Phe 
            180                 185                 190         


Ser Phe Ser Thr Ser Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys 
        195                 200                 205             


Glu Leu Glu Phe Val Ala Ala Ile Asp Trp Ser Asp Phe Asn Thr Tyr 
    210                 215                 220                 


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg His Asn Pro 
225                 230                 235                 240 


Arg Asn Ser Val Tyr Leu Gln Leu Asn Ser Leu Lys Pro Glu Asp Thr 
                245                 250                 255     


Ala Leu Tyr Tyr Cys Ala Ala His Ser Glu Thr Arg Gly Gly Thr Arg 
            260                 265                 270         


Tyr Phe Asp Arg Pro Ser Leu Tyr Asn Tyr Trp Gly Gln Gly Thr Leu 
        275                 280                 285             


Val Lys Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val 
    290                 295                 300                 


Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Asn Ser Leu 
305                 310                 315                 320 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe Gly Met 
                325                 330                 335     


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser 
            340                 345                 350         


Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val Lys Gly 
        355                 360                 365             


Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr Leu Gln 
    370                 375                 380                 


Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Thr Ile 
385                 390                 395                 400 


Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr Val Ser 
                405                 410                 415     


Ser Ala 
        


<210>  110
<211>  418
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  110

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Arg His Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Ser Tyr Gly Ser Thr Asp Tyr Gly Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn Thr Val Pro Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Ala Asp Glu Thr Leu Gly Ala Val Pro Asn Phe Arg Leu His Glu 
            100                 105                 110         


Lys Tyr Glu Tyr Glu Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
145                 150                 155                 160 


Gly Gly Gly Glu Val Gln Leu Val Glu Ser Gly Gly Lys Val Val Gln 
                165                 170                 175     


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Arg Thr Phe 
            180                 185                 190         


Ser Phe Ser Thr Ser Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys 
        195                 200                 205             


Glu Leu Glu Phe Val Ala Ala Ile Asp Trp Ser Asp Phe Asn Thr Tyr 
    210                 215                 220                 


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg His Asn Pro 
225                 230                 235                 240 


Arg Asn Ser Val Tyr Leu Gln Leu Asn Ser Leu Lys Pro Glu Asp Thr 
                245                 250                 255     


Ala Leu Tyr Tyr Cys Ala Ala His Ser Glu Thr Arg Gly Gly Thr Arg 
            260                 265                 270         


Tyr Phe Asp Arg Pro Ser Leu Tyr Asn Tyr Trp Gly Gln Gly Thr Leu 
        275                 280                 285             


Val Lys Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val 
    290                 295                 300                 


Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Asn Ser Leu 
305                 310                 315                 320 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe Gly Met 
                325                 330                 335     


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser 
            340                 345                 350         


Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val Lys Gly 
        355                 360                 365             


Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr Leu Gln 
    370                 375                 380                 


Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Thr Ile 
385                 390                 395                 400 


Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Lys Val Ser 
                405                 410                 415     


Ser Ala 
        


<210>  111
<211>  418
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  111

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Arg His Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Ser Tyr Gly Ser Thr Asp Tyr Gly Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn Thr Val Pro Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Ala Asp Glu Thr Leu Gly Ala Val Pro Asn Phe Arg Leu His Glu 
            100                 105                 110         


Lys Tyr Glu Tyr Glu Tyr Trp Gly Gln Gly Thr Leu Val Lys Val Ser 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
145                 150                 155                 160 


Gly Gly Gly Glu Val Gln Leu Val Glu Ser Gly Gly Lys Val Val Gln 
                165                 170                 175     


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Arg Thr Phe 
            180                 185                 190         


Ser Phe Ser Thr Ser Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys 
        195                 200                 205             


Glu Leu Glu Phe Val Ala Ala Ile Asp Trp Ser Asp Phe Asn Thr Tyr 
    210                 215                 220                 


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg His Asn Pro 
225                 230                 235                 240 


Arg Asn Ser Val Tyr Leu Gln Leu Asn Ser Leu Lys Pro Glu Asp Thr 
                245                 250                 255     


Ala Leu Tyr Tyr Cys Ala Ala His Ser Glu Thr Arg Gly Gly Thr Arg 
            260                 265                 270         


Tyr Phe Asp Arg Pro Ser Leu Tyr Asn Tyr Trp Gly Gln Gly Thr Leu 
        275                 280                 285             


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val 
    290                 295                 300                 


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Asn Ser Leu 
305                 310                 315                 320 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe Gly Met 
                325                 330                 335     


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser 
            340                 345                 350         


Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val Lys Gly 
        355                 360                 365             


Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr Leu Gln 
    370                 375                 380                 


Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Thr Ile 
385                 390                 395                 400 


Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr Val Ser 
                405                 410                 415     


Ser Ala 
        


<210>  112
<211>  418
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  112

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Arg His Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Ser Tyr Gly Ser Thr Asp Tyr Gly Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn Thr Val Pro Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Ala Asp Glu Thr Leu Gly Ala Val Pro Asn Phe Arg Leu His Glu 
            100                 105                 110         


Lys Tyr Glu Tyr Glu Tyr Trp Gly Gln Gly Thr Leu Val Lys Val Ser 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
145                 150                 155                 160 


Gly Gly Gly Glu Val Gln Leu Val Glu Ser Gly Gly Lys Val Val Gln 
                165                 170                 175     


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Arg Thr Phe 
            180                 185                 190         


Ser Phe Ser Thr Ser Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys 
        195                 200                 205             


Glu Leu Glu Phe Val Ala Ala Ile Asp Trp Ser Asp Phe Asn Thr Tyr 
    210                 215                 220                 


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg His Asn Pro 
225                 230                 235                 240 


Arg Asn Ser Val Tyr Leu Gln Leu Asn Ser Leu Lys Pro Glu Asp Thr 
                245                 250                 255     


Ala Leu Tyr Tyr Cys Ala Ala His Ser Glu Thr Arg Gly Gly Thr Arg 
            260                 265                 270         


Tyr Phe Asp Arg Pro Ser Leu Tyr Asn Tyr Trp Gly Gln Gly Thr Leu 
        275                 280                 285             


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val 
    290                 295                 300                 


Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Asn Ser Leu 
305                 310                 315                 320 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe Gly Met 
                325                 330                 335     


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser 
            340                 345                 350         


Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val Lys Gly 
        355                 360                 365             


Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr Leu Gln 
    370                 375                 380                 


Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Thr Ile 
385                 390                 395                 400 


Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr Val Ser 
                405                 410                 415     


Ser Ala 
        


<210>  113
<211>  418
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  113

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Arg His Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Ser Tyr Gly Ser Thr Asp Tyr Gly Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn Thr Val Pro Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Ala Asp Glu Thr Leu Gly Ala Val Pro Asn Phe Arg Leu His Glu 
            100                 105                 110         


Lys Tyr Glu Tyr Glu Tyr Trp Gly Gln Gly Thr Leu Val Lys Val Ser 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
145                 150                 155                 160 


Gly Gly Gly Glu Val Gln Leu Val Glu Ser Gly Gly Lys Val Val Gln 
                165                 170                 175     


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Arg Thr Phe 
            180                 185                 190         


Ser Phe Ser Thr Ser Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys 
        195                 200                 205             


Glu Leu Glu Phe Val Ala Ala Ile Asp Trp Ser Asp Phe Asn Thr Tyr 
    210                 215                 220                 


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg His Asn Pro 
225                 230                 235                 240 


Arg Asn Ser Val Tyr Leu Gln Leu Asn Ser Leu Lys Pro Glu Asp Thr 
                245                 250                 255     


Ala Leu Tyr Tyr Cys Ala Ala His Ser Glu Thr Arg Gly Gly Thr Arg 
            260                 265                 270         


Tyr Phe Asp Arg Pro Ser Leu Tyr Asn Tyr Trp Gly Gln Gly Thr Leu 
        275                 280                 285             


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val 
    290                 295                 300                 


Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Asn Ser Leu 
305                 310                 315                 320 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe Gly Met 
                325                 330                 335     


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser 
            340                 345                 350         


Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val Lys Gly 
        355                 360                 365             


Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr Leu Gln 
    370                 375                 380                 


Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Thr Ile 
385                 390                 395                 400 


Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Lys Val Ser 
                405                 410                 415     


Ser Ala 
        


<210>  114
<211>  418
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  114

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Arg His Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Ser Tyr Gly Ser Thr Asp Tyr Gly Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn Thr Val Pro Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Ala Asp Glu Thr Leu Gly Ala Val Pro Asn Phe Arg Leu His Glu 
            100                 105                 110         


Lys Tyr Glu Tyr Glu Tyr Trp Gly Gln Gly Thr Leu Val Lys Val Ser 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
145                 150                 155                 160 


Gly Gly Gly Glu Val Gln Leu Val Glu Ser Gly Gly Lys Val Val Gln 
                165                 170                 175     


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Arg Thr Phe 
            180                 185                 190         


Ser Phe Ser Thr Ser Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys 
        195                 200                 205             


Glu Leu Glu Phe Val Ala Ala Ile Asp Trp Ser Asp Phe Asn Thr Tyr 
    210                 215                 220                 


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg His Asn Pro 
225                 230                 235                 240 


Arg Asn Ser Val Tyr Leu Gln Leu Asn Ser Leu Lys Pro Glu Asp Thr 
                245                 250                 255     


Ala Leu Tyr Tyr Cys Ala Ala His Ser Glu Thr Arg Gly Gly Thr Arg 
            260                 265                 270         


Tyr Phe Asp Arg Pro Ser Leu Tyr Asn Tyr Trp Gly Gln Gly Thr Leu 
        275                 280                 285             


Val Lys Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val 
    290                 295                 300                 


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Asn Ser Leu 
305                 310                 315                 320 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe Gly Met 
                325                 330                 335     


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser 
            340                 345                 350         


Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val Lys Gly 
        355                 360                 365             


Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr Leu Gln 
    370                 375                 380                 


Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Thr Ile 
385                 390                 395                 400 


Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr Val Ser 
                405                 410                 415     


Ser Ala 
        


<210>  115
<211>  418
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  115

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Arg His Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Ser Tyr Gly Ser Thr Asp Tyr Gly Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn Thr Val Pro Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Ala Asp Glu Thr Leu Gly Ala Val Pro Asn Phe Arg Leu His Glu 
            100                 105                 110         


Lys Tyr Glu Tyr Glu Tyr Trp Gly Gln Gly Thr Leu Val Lys Val Ser 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
145                 150                 155                 160 


Gly Gly Gly Glu Val Gln Leu Val Glu Ser Gly Gly Lys Val Val Gln 
                165                 170                 175     


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Arg Thr Phe 
            180                 185                 190         


Ser Phe Ser Thr Ser Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys 
        195                 200                 205             


Glu Leu Glu Phe Val Ala Ala Ile Asp Trp Ser Asp Phe Asn Thr Tyr 
    210                 215                 220                 


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg His Asn Pro 
225                 230                 235                 240 


Arg Asn Ser Val Tyr Leu Gln Leu Asn Ser Leu Lys Pro Glu Asp Thr 
                245                 250                 255     


Ala Leu Tyr Tyr Cys Ala Ala His Ser Glu Thr Arg Gly Gly Thr Arg 
            260                 265                 270         


Tyr Phe Asp Arg Pro Ser Leu Tyr Asn Tyr Trp Gly Gln Gly Thr Leu 
        275                 280                 285             


Val Lys Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val 
    290                 295                 300                 


Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Asn Ser Leu 
305                 310                 315                 320 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe Gly Met 
                325                 330                 335     


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser 
            340                 345                 350         


Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val Lys Gly 
        355                 360                 365             


Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr Leu Gln 
    370                 375                 380                 


Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Thr Ile 
385                 390                 395                 400 


Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr Val Ser 
                405                 410                 415     


Ser Ala 
        


<210>  116
<211>  418
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  116

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Arg His Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Ser Tyr Gly Ser Thr Asp Tyr Gly Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn Thr Val Pro Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Ala Asp Glu Thr Leu Gly Ala Val Pro Asn Phe Arg Leu His Glu 
            100                 105                 110         


Lys Tyr Glu Tyr Glu Tyr Trp Gly Gln Gly Thr Leu Val Lys Val Ser 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
145                 150                 155                 160 


Gly Gly Gly Glu Val Gln Leu Val Glu Ser Gly Gly Lys Val Val Gln 
                165                 170                 175     


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Arg Thr Phe 
            180                 185                 190         


Ser Phe Ser Thr Ser Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys 
        195                 200                 205             


Glu Leu Glu Phe Val Ala Ala Ile Asp Trp Ser Asp Phe Asn Thr Tyr 
    210                 215                 220                 


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg His Asn Pro 
225                 230                 235                 240 


Arg Asn Ser Val Tyr Leu Gln Leu Asn Ser Leu Lys Pro Glu Asp Thr 
                245                 250                 255     


Ala Leu Tyr Tyr Cys Ala Ala His Ser Glu Thr Arg Gly Gly Thr Arg 
            260                 265                 270         


Tyr Phe Asp Arg Pro Ser Leu Tyr Asn Tyr Trp Gly Gln Gly Thr Leu 
        275                 280                 285             


Val Lys Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val 
    290                 295                 300                 


Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Asn Ser Leu 
305                 310                 315                 320 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe Gly Met 
                325                 330                 335     


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser 
            340                 345                 350         


Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val Lys Gly 
        355                 360                 365             


Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr Leu Gln 
    370                 375                 380                 


Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Thr Ile 
385                 390                 395                 400 


Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Lys Val Ser 
                405                 410                 415     


Ser Ala 
        


<210>  117
<211>  418
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  117

Asp Val Gln Leu Val Glu Ser Gly Gly Lys Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Arg Thr Phe Ser Phe Ser 
            20                  25                  30          


Thr Ser Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Leu Glu 
        35                  40                  45              


Phe Val Ala Ala Ile Asp Trp Ser Asp Phe Asn Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg His Asn Pro Arg Asn Ser 
65                  70                  75                  80  


Val Tyr Leu Gln Leu Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr 
                85                  90                  95      


Tyr Cys Ala Ala His Ser Glu Thr Arg Gly Gly Thr Arg Tyr Phe Asp 
            100                 105                 110         


Arg Pro Ser Leu Tyr Asn Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
        115                 120                 125             


Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
145                 150                 155                 160 


Gly Gly Gly Gly Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val 
                165                 170                 175     


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr 
            180                 185                 190         


Phe Arg His Tyr Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu 
        195                 200                 205             


Arg Glu Phe Val Ala Ala Ile Ser Ser Tyr Gly Ser Thr Asp Tyr Gly 
    210                 215                 220                 


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn 
225                 230                 235                 240 


Thr Val Pro Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu 
                245                 250                 255     


Tyr Tyr Cys Ala Ala Ala Asp Glu Thr Leu Gly Ala Val Pro Asn Phe 
            260                 265                 270         


Arg Leu His Glu Lys Tyr Glu Tyr Glu Tyr Trp Gly Gln Gly Thr Leu 
        275                 280                 285             


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val 
    290                 295                 300                 


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Asn Ser Leu 
305                 310                 315                 320 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe Gly Met 
                325                 330                 335     


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser 
            340                 345                 350         


Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val Lys Gly 
        355                 360                 365             


Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr Leu Gln 
    370                 375                 380                 


Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Thr Ile 
385                 390                 395                 400 


Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr Val Ser 
                405                 410                 415     


Ser Ala 
        


<210>  118
<211>  418
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  118

Asp Val Gln Leu Val Glu Ser Gly Gly Lys Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Arg Thr Phe Ser Phe Ser 
            20                  25                  30          


Thr Ser Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Leu Glu 
        35                  40                  45              


Phe Val Ala Ala Ile Asp Trp Ser Asp Phe Asn Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg His Asn Pro Arg Asn Ser 
65                  70                  75                  80  


Val Tyr Leu Gln Leu Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr 
                85                  90                  95      


Tyr Cys Ala Ala His Ser Glu Thr Arg Gly Gly Thr Arg Tyr Phe Asp 
            100                 105                 110         


Arg Pro Ser Leu Tyr Asn Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
        115                 120                 125             


Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
145                 150                 155                 160 


Gly Gly Gly Gly Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val 
                165                 170                 175     


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr 
            180                 185                 190         


Phe Arg His Tyr Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu 
        195                 200                 205             


Arg Glu Phe Val Ala Ala Ile Ser Ser Tyr Gly Ser Thr Asp Tyr Gly 
    210                 215                 220                 


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn 
225                 230                 235                 240 


Thr Val Pro Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu 
                245                 250                 255     


Tyr Tyr Cys Ala Ala Ala Asp Glu Thr Leu Gly Ala Val Pro Asn Phe 
            260                 265                 270         


Arg Leu His Glu Lys Tyr Glu Tyr Glu Tyr Trp Gly Gln Gly Thr Leu 
        275                 280                 285             


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val 
    290                 295                 300                 


Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Asn Ser Leu 
305                 310                 315                 320 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe Gly Met 
                325                 330                 335     


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser 
            340                 345                 350         


Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val Lys Gly 
        355                 360                 365             


Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr Leu Gln 
    370                 375                 380                 


Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Thr Ile 
385                 390                 395                 400 


Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr Val Ser 
                405                 410                 415     


Ser Ala 
        


<210>  119
<211>  418
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  119

Asp Val Gln Leu Val Glu Ser Gly Gly Lys Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Arg Thr Phe Ser Phe Ser 
            20                  25                  30          


Thr Ser Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Leu Glu 
        35                  40                  45              


Phe Val Ala Ala Ile Asp Trp Ser Asp Phe Asn Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg His Asn Pro Arg Asn Ser 
65                  70                  75                  80  


Val Tyr Leu Gln Leu Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr 
                85                  90                  95      


Tyr Cys Ala Ala His Ser Glu Thr Arg Gly Gly Thr Arg Tyr Phe Asp 
            100                 105                 110         


Arg Pro Ser Leu Tyr Asn Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
        115                 120                 125             


Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
145                 150                 155                 160 


Gly Gly Gly Gly Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val 
                165                 170                 175     


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr 
            180                 185                 190         


Phe Arg His Tyr Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu 
        195                 200                 205             


Arg Glu Phe Val Ala Ala Ile Ser Ser Tyr Gly Ser Thr Asp Tyr Gly 
    210                 215                 220                 


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn 
225                 230                 235                 240 


Thr Val Pro Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu 
                245                 250                 255     


Tyr Tyr Cys Ala Ala Ala Asp Glu Thr Leu Gly Ala Val Pro Asn Phe 
            260                 265                 270         


Arg Leu His Glu Lys Tyr Glu Tyr Glu Tyr Trp Gly Gln Gly Thr Leu 
        275                 280                 285             


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val 
    290                 295                 300                 


Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Asn Ser Leu 
305                 310                 315                 320 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe Gly Met 
                325                 330                 335     


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser 
            340                 345                 350         


Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val Lys Gly 
        355                 360                 365             


Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr Leu Gln 
    370                 375                 380                 


Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Thr Ile 
385                 390                 395                 400 


Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Lys Val Ser 
                405                 410                 415     


Ser Ala 
        


<210>  120
<211>  418
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  120

Asp Val Gln Leu Val Glu Ser Gly Gly Lys Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Arg Thr Phe Ser Phe Ser 
            20                  25                  30          


Thr Ser Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Leu Glu 
        35                  40                  45              


Phe Val Ala Ala Ile Asp Trp Ser Asp Phe Asn Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg His Asn Pro Arg Asn Ser 
65                  70                  75                  80  


Val Tyr Leu Gln Leu Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr 
                85                  90                  95      


Tyr Cys Ala Ala His Ser Glu Thr Arg Gly Gly Thr Arg Tyr Phe Asp 
            100                 105                 110         


Arg Pro Ser Leu Tyr Asn Tyr Trp Gly Gln Gly Thr Leu Val Lys Val 
        115                 120                 125             


Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
145                 150                 155                 160 


Gly Gly Gly Gly Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val 
                165                 170                 175     


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr 
            180                 185                 190         


Phe Arg His Tyr Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu 
        195                 200                 205             


Arg Glu Phe Val Ala Ala Ile Ser Ser Tyr Gly Ser Thr Asp Tyr Gly 
    210                 215                 220                 


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn 
225                 230                 235                 240 


Thr Val Pro Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu 
                245                 250                 255     


Tyr Tyr Cys Ala Ala Ala Asp Glu Thr Leu Gly Ala Val Pro Asn Phe 
            260                 265                 270         


Arg Leu His Glu Lys Tyr Glu Tyr Glu Tyr Trp Gly Gln Gly Thr Leu 
        275                 280                 285             


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val 
    290                 295                 300                 


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Asn Ser Leu 
305                 310                 315                 320 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe Gly Met 
                325                 330                 335     


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser 
            340                 345                 350         


Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val Lys Gly 
        355                 360                 365             


Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr Leu Gln 
    370                 375                 380                 


Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Thr Ile 
385                 390                 395                 400 


Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr Val Ser 
                405                 410                 415     


Ser Ala 
        


<210>  121
<211>  418
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  121

Asp Val Gln Leu Val Glu Ser Gly Gly Lys Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Arg Thr Phe Ser Phe Ser 
            20                  25                  30          


Thr Ser Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Leu Glu 
        35                  40                  45              


Phe Val Ala Ala Ile Asp Trp Ser Asp Phe Asn Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg His Asn Pro Arg Asn Ser 
65                  70                  75                  80  


Val Tyr Leu Gln Leu Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr 
                85                  90                  95      


Tyr Cys Ala Ala His Ser Glu Thr Arg Gly Gly Thr Arg Tyr Phe Asp 
            100                 105                 110         


Arg Pro Ser Leu Tyr Asn Tyr Trp Gly Gln Gly Thr Leu Val Lys Val 
        115                 120                 125             


Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
145                 150                 155                 160 


Gly Gly Gly Gly Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val 
                165                 170                 175     


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr 
            180                 185                 190         


Phe Arg His Tyr Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu 
        195                 200                 205             


Arg Glu Phe Val Ala Ala Ile Ser Ser Tyr Gly Ser Thr Asp Tyr Gly 
    210                 215                 220                 


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn 
225                 230                 235                 240 


Thr Val Pro Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu 
                245                 250                 255     


Tyr Tyr Cys Ala Ala Ala Asp Glu Thr Leu Gly Ala Val Pro Asn Phe 
            260                 265                 270         


Arg Leu His Glu Lys Tyr Glu Tyr Glu Tyr Trp Gly Gln Gly Thr Leu 
        275                 280                 285             


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val 
    290                 295                 300                 


Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Asn Ser Leu 
305                 310                 315                 320 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe Gly Met 
                325                 330                 335     


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser 
            340                 345                 350         


Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val Lys Gly 
        355                 360                 365             


Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr Leu Gln 
    370                 375                 380                 


Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Thr Ile 
385                 390                 395                 400 


Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr Val Ser 
                405                 410                 415     


Ser Ala 
        


<210>  122
<211>  418
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  122

Asp Val Gln Leu Val Glu Ser Gly Gly Lys Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Arg Thr Phe Ser Phe Ser 
            20                  25                  30          


Thr Ser Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Leu Glu 
        35                  40                  45              


Phe Val Ala Ala Ile Asp Trp Ser Asp Phe Asn Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg His Asn Pro Arg Asn Ser 
65                  70                  75                  80  


Val Tyr Leu Gln Leu Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr 
                85                  90                  95      


Tyr Cys Ala Ala His Ser Glu Thr Arg Gly Gly Thr Arg Tyr Phe Asp 
            100                 105                 110         


Arg Pro Ser Leu Tyr Asn Tyr Trp Gly Gln Gly Thr Leu Val Lys Val 
        115                 120                 125             


Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
145                 150                 155                 160 


Gly Gly Gly Gly Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val 
                165                 170                 175     


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr 
            180                 185                 190         


Phe Arg His Tyr Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu 
        195                 200                 205             


Arg Glu Phe Val Ala Ala Ile Ser Ser Tyr Gly Ser Thr Asp Tyr Gly 
    210                 215                 220                 


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn 
225                 230                 235                 240 


Thr Val Pro Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu 
                245                 250                 255     


Tyr Tyr Cys Ala Ala Ala Asp Glu Thr Leu Gly Ala Val Pro Asn Phe 
            260                 265                 270         


Arg Leu His Glu Lys Tyr Glu Tyr Glu Tyr Trp Gly Gln Gly Thr Leu 
        275                 280                 285             


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val 
    290                 295                 300                 


Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Asn Ser Leu 
305                 310                 315                 320 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe Gly Met 
                325                 330                 335     


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser 
            340                 345                 350         


Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val Lys Gly 
        355                 360                 365             


Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr Leu Gln 
    370                 375                 380                 


Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Thr Ile 
385                 390                 395                 400 


Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Lys Val Ser 
                405                 410                 415     


Ser Ala 
        


<210>  123
<211>  418
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  123

Asp Val Gln Leu Val Glu Ser Gly Gly Lys Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Arg Thr Phe Ser Phe Ser 
            20                  25                  30          


Thr Ser Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Leu Glu 
        35                  40                  45              


Phe Val Ala Ala Ile Asp Trp Ser Asp Phe Asn Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg His Asn Pro Arg Asn Ser 
65                  70                  75                  80  


Val Tyr Leu Gln Leu Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr 
                85                  90                  95      


Tyr Cys Ala Ala His Ser Glu Thr Arg Gly Gly Thr Arg Tyr Phe Asp 
            100                 105                 110         


Arg Pro Ser Leu Tyr Asn Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
        115                 120                 125             


Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
145                 150                 155                 160 


Gly Gly Gly Gly Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val 
                165                 170                 175     


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr 
            180                 185                 190         


Phe Arg His Tyr Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu 
        195                 200                 205             


Arg Glu Phe Val Ala Ala Ile Ser Ser Tyr Gly Ser Thr Asp Tyr Gly 
    210                 215                 220                 


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn 
225                 230                 235                 240 


Thr Val Pro Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu 
                245                 250                 255     


Tyr Tyr Cys Ala Ala Ala Asp Glu Thr Leu Gly Ala Val Pro Asn Phe 
            260                 265                 270         


Arg Leu His Glu Lys Tyr Glu Tyr Glu Tyr Trp Gly Gln Gly Thr Leu 
        275                 280                 285             


Val Lys Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val 
    290                 295                 300                 


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Asn Ser Leu 
305                 310                 315                 320 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe Gly Met 
                325                 330                 335     


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser 
            340                 345                 350         


Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val Lys Gly 
        355                 360                 365             


Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr Leu Gln 
    370                 375                 380                 


Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Thr Ile 
385                 390                 395                 400 


Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr Val Ser 
                405                 410                 415     


Ser Ala 
        


<210>  124
<211>  418
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  124

Asp Val Gln Leu Val Glu Ser Gly Gly Lys Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Arg Thr Phe Ser Phe Ser 
            20                  25                  30          


Thr Ser Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Leu Glu 
        35                  40                  45              


Phe Val Ala Ala Ile Asp Trp Ser Asp Phe Asn Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg His Asn Pro Arg Asn Ser 
65                  70                  75                  80  


Val Tyr Leu Gln Leu Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr 
                85                  90                  95      


Tyr Cys Ala Ala His Ser Glu Thr Arg Gly Gly Thr Arg Tyr Phe Asp 
            100                 105                 110         


Arg Pro Ser Leu Tyr Asn Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
        115                 120                 125             


Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
145                 150                 155                 160 


Gly Gly Gly Gly Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val 
                165                 170                 175     


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr 
            180                 185                 190         


Phe Arg His Tyr Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu 
        195                 200                 205             


Arg Glu Phe Val Ala Ala Ile Ser Ser Tyr Gly Ser Thr Asp Tyr Gly 
    210                 215                 220                 


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn 
225                 230                 235                 240 


Thr Val Pro Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu 
                245                 250                 255     


Tyr Tyr Cys Ala Ala Ala Asp Glu Thr Leu Gly Ala Val Pro Asn Phe 
            260                 265                 270         


Arg Leu His Glu Lys Tyr Glu Tyr Glu Tyr Trp Gly Gln Gly Thr Leu 
        275                 280                 285             


Val Lys Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val 
    290                 295                 300                 


Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Asn Ser Leu 
305                 310                 315                 320 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe Gly Met 
                325                 330                 335     


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser 
            340                 345                 350         


Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val Lys Gly 
        355                 360                 365             


Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr Leu Gln 
    370                 375                 380                 


Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Thr Ile 
385                 390                 395                 400 


Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr Val Ser 
                405                 410                 415     


Ser Ala 
        


<210>  125
<211>  418
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  125

Asp Val Gln Leu Val Glu Ser Gly Gly Lys Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Arg Thr Phe Ser Phe Ser 
            20                  25                  30          


Thr Ser Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Leu Glu 
        35                  40                  45              


Phe Val Ala Ala Ile Asp Trp Ser Asp Phe Asn Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg His Asn Pro Arg Asn Ser 
65                  70                  75                  80  


Val Tyr Leu Gln Leu Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr 
                85                  90                  95      


Tyr Cys Ala Ala His Ser Glu Thr Arg Gly Gly Thr Arg Tyr Phe Asp 
            100                 105                 110         


Arg Pro Ser Leu Tyr Asn Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
        115                 120                 125             


Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
145                 150                 155                 160 


Gly Gly Gly Gly Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val 
                165                 170                 175     


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr 
            180                 185                 190         


Phe Arg His Tyr Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu 
        195                 200                 205             


Arg Glu Phe Val Ala Ala Ile Ser Ser Tyr Gly Ser Thr Asp Tyr Gly 
    210                 215                 220                 


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn 
225                 230                 235                 240 


Thr Val Pro Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu 
                245                 250                 255     


Tyr Tyr Cys Ala Ala Ala Asp Glu Thr Leu Gly Ala Val Pro Asn Phe 
            260                 265                 270         


Arg Leu His Glu Lys Tyr Glu Tyr Glu Tyr Trp Gly Gln Gly Thr Leu 
        275                 280                 285             


Val Lys Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val 
    290                 295                 300                 


Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Asn Ser Leu 
305                 310                 315                 320 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe Gly Met 
                325                 330                 335     


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser 
            340                 345                 350         


Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val Lys Gly 
        355                 360                 365             


Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr Leu Gln 
    370                 375                 380                 


Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Thr Ile 
385                 390                 395                 400 


Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Lys Val Ser 
                405                 410                 415     


Ser Ala 
        


<210>  126
<211>  418
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  126

Asp Val Gln Leu Val Glu Ser Gly Gly Lys Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Arg Thr Phe Ser Phe Ser 
            20                  25                  30          


Thr Ser Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Leu Glu 
        35                  40                  45              


Phe Val Ala Ala Ile Asp Trp Ser Asp Phe Asn Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg His Asn Pro Arg Asn Ser 
65                  70                  75                  80  


Val Tyr Leu Gln Leu Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr 
                85                  90                  95      


Tyr Cys Ala Ala His Ser Glu Thr Arg Gly Gly Thr Arg Tyr Phe Asp 
            100                 105                 110         


Arg Pro Ser Leu Tyr Asn Tyr Trp Gly Gln Gly Thr Leu Val Lys Val 
        115                 120                 125             


Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
145                 150                 155                 160 


Gly Gly Gly Gly Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val 
                165                 170                 175     


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr 
            180                 185                 190         


Phe Arg His Tyr Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu 
        195                 200                 205             


Arg Glu Phe Val Ala Ala Ile Ser Ser Tyr Gly Ser Thr Asp Tyr Gly 
    210                 215                 220                 


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn 
225                 230                 235                 240 


Thr Val Pro Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu 
                245                 250                 255     


Tyr Tyr Cys Ala Ala Ala Asp Glu Thr Leu Gly Ala Val Pro Asn Phe 
            260                 265                 270         


Arg Leu His Glu Lys Tyr Glu Tyr Glu Tyr Trp Gly Gln Gly Thr Leu 
        275                 280                 285             


Val Lys Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val 
    290                 295                 300                 


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Asn Ser Leu 
305                 310                 315                 320 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe Gly Met 
                325                 330                 335     


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser 
            340                 345                 350         


Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val Lys Gly 
        355                 360                 365             


Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr Leu Gln 
    370                 375                 380                 


Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Thr Ile 
385                 390                 395                 400 


Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr Val Ser 
                405                 410                 415     


Ser Ala 
        


<210>  127
<211>  418
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  127

Asp Val Gln Leu Val Glu Ser Gly Gly Lys Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Arg Thr Phe Ser Phe Ser 
            20                  25                  30          


Thr Ser Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Leu Glu 
        35                  40                  45              


Phe Val Ala Ala Ile Asp Trp Ser Asp Phe Asn Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg His Asn Pro Arg Asn Ser 
65                  70                  75                  80  


Val Tyr Leu Gln Leu Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr 
                85                  90                  95      


Tyr Cys Ala Ala His Ser Glu Thr Arg Gly Gly Thr Arg Tyr Phe Asp 
            100                 105                 110         


Arg Pro Ser Leu Tyr Asn Tyr Trp Gly Gln Gly Thr Leu Val Lys Val 
        115                 120                 125             


Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
145                 150                 155                 160 


Gly Gly Gly Gly Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val 
                165                 170                 175     


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr 
            180                 185                 190         


Phe Arg His Tyr Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu 
        195                 200                 205             


Arg Glu Phe Val Ala Ala Ile Ser Ser Tyr Gly Ser Thr Asp Tyr Gly 
    210                 215                 220                 


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn 
225                 230                 235                 240 


Thr Val Pro Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu 
                245                 250                 255     


Tyr Tyr Cys Ala Ala Ala Asp Glu Thr Leu Gly Ala Val Pro Asn Phe 
            260                 265                 270         


Arg Leu His Glu Lys Tyr Glu Tyr Glu Tyr Trp Gly Gln Gly Thr Leu 
        275                 280                 285             


Val Lys Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val 
    290                 295                 300                 


Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Asn Ser Leu 
305                 310                 315                 320 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe Gly Met 
                325                 330                 335     


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser 
            340                 345                 350         


Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val Lys Gly 
        355                 360                 365             


Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr Leu Gln 
    370                 375                 380                 


Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Thr Ile 
385                 390                 395                 400 


Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr Val Ser 
                405                 410                 415     


Ser Ala 
        


<210>  128
<211>  418
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  128

Asp Val Gln Leu Val Glu Ser Gly Gly Lys Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Arg Thr Phe Ser Phe Ser 
            20                  25                  30          


Thr Ser Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Leu Glu 
        35                  40                  45              


Phe Val Ala Ala Ile Asp Trp Ser Asp Phe Asn Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg His Asn Pro Arg Asn Ser 
65                  70                  75                  80  


Val Tyr Leu Gln Leu Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr 
                85                  90                  95      


Tyr Cys Ala Ala His Ser Glu Thr Arg Gly Gly Thr Arg Tyr Phe Asp 
            100                 105                 110         


Arg Pro Ser Leu Tyr Asn Tyr Trp Gly Gln Gly Thr Leu Val Lys Val 
        115                 120                 125             


Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
145                 150                 155                 160 


Gly Gly Gly Gly Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val 
                165                 170                 175     


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr 
            180                 185                 190         


Phe Arg His Tyr Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu 
        195                 200                 205             


Arg Glu Phe Val Ala Ala Ile Ser Ser Tyr Gly Ser Thr Asp Tyr Gly 
    210                 215                 220                 


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn 
225                 230                 235                 240 


Thr Val Pro Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu 
                245                 250                 255     


Tyr Tyr Cys Ala Ala Ala Asp Glu Thr Leu Gly Ala Val Pro Asn Phe 
            260                 265                 270         


Arg Leu His Glu Lys Tyr Glu Tyr Glu Tyr Trp Gly Gln Gly Thr Leu 
        275                 280                 285             


Val Lys Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val 
    290                 295                 300                 


Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Asn Ser Leu 
305                 310                 315                 320 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe Gly Met 
                325                 330                 335     


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser 
            340                 345                 350         


Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val Lys Gly 
        355                 360                 365             


Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr Leu Gln 
    370                 375                 380                 


Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Thr Ile 
385                 390                 395                 400 


Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Lys Val Ser 
                405                 410                 415     


Ser Ala 
        


<210>  129
<211>  130
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  129

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Arg Thr Phe Ser Phe Ser 
            20                  25                  30          


Thr Ser Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Leu Glu 
        35                  40                  45              


Phe Val Ala Ala Ile Asp Trp Ser Asp Phe Asn Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg His Asn Pro Arg Asn Ser 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Ala His Ser Glu Thr Arg Gly Gly Thr Arg Tyr Phe Asp 
            100                 105                 110         


Arg Pro Ser Leu Tyr Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val 
        115                 120                 125             


Ser Ser 
    130 


<210>  130
<211>  130
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  130

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Arg Thr Phe Ser Phe Ser 
            20                  25                  30          


Thr Ser Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu 
        35                  40                  45              


Phe Val Ala Ala Ile Asp Trp Ser Asp Phe Asn Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg His Asn Pro Arg Asn Ser 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Ala His Ser Glu Thr Arg Gly Gly Thr Arg Tyr Phe Asp 
            100                 105                 110         


Arg Pro Ser Leu Tyr Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val 
        115                 120                 125             


Ser Ser 
    130 


<210>  131
<211>  130
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  131

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Arg Thr Phe Ser Phe Ser 
            20                  25                  30          


Thr Ser Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Leu Glu 
        35                  40                  45              


Phe Val Ala Ala Ile Asp Trp Ser Asp Phe Asn Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Pro Arg Asn Ser 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Ala His Ser Glu Thr Arg Gly Gly Thr Arg Tyr Phe Asp 
            100                 105                 110         


Arg Pro Ser Leu Tyr Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val 
        115                 120                 125             


Ser Ser 
    130 


<210>  132
<211>  130
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  132

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Arg Thr Phe Ser Phe Ser 
            20                  25                  30          


Thr Ser Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Leu Glu 
        35                  40                  45              


Phe Val Ala Ala Ile Asp Trp Ser Asp Phe Asn Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg His Asn Ser Arg Asn Ser 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Ala His Ser Glu Thr Arg Gly Gly Thr Arg Tyr Phe Asp 
            100                 105                 110         


Arg Pro Ser Leu Tyr Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val 
        115                 120                 125             


Ser Ser 
    130 


<210>  133
<211>  130
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  133

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Arg Thr Phe Ser Phe Ser 
            20                  25                  30          


Thr Ser Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Leu Glu 
        35                  40                  45              


Phe Val Ala Ala Ile Asp Trp Ser Asp Phe Asn Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg His Asn Pro Lys Asn Ser 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Ala His Ser Glu Thr Arg Gly Gly Thr Arg Tyr Phe Asp 
            100                 105                 110         


Arg Pro Ser Leu Tyr Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val 
        115                 120                 125             


Ser Ser 
    130 


<210>  134
<211>  130
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  134

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Arg Thr Phe Ser Phe Ser 
            20                  25                  30          


Thr Ser Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Leu Glu 
        35                  40                  45              


Phe Val Ala Ala Ile Asp Trp Ser Asp Phe Asn Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg His Asn Pro Arg Asn Thr 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Ala His Ser Glu Thr Arg Gly Gly Thr Arg Tyr Phe Asp 
            100                 105                 110         


Arg Pro Ser Leu Tyr Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val 
        115                 120                 125             


Ser Ser 
    130 


<210>  135
<211>  130
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  135

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Arg Thr Phe Ser Phe Ser 
            20                  25                  30          


Thr Ser Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu 
        35                  40                  45              


Phe Val Ala Ala Ile Asp Trp Ser Asp Phe Asn Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Ala His Ser Glu Thr Arg Gly Gly Thr Arg Tyr Phe Asp 
            100                 105                 110         


Arg Pro Ser Leu Tyr Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val 
        115                 120                 125             


Ser Ser 
    130 


<210>  136
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  136

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Arg His Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Ser Tyr Gly Ser Thr Asp Tyr Gly Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Val Pro Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Ala Asp Glu Thr Leu Gly Ala Val Pro Asn Phe Arg Leu His Glu 
            100                 105                 110         


Lys Tyr Glu Tyr Glu Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  137
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  137

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Arg His Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Ser Tyr Gly Ser Thr Asp Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Val Pro Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Ala Asp Glu Thr Leu Gly Ala Val Pro Asn Phe Arg Leu His Glu 
            100                 105                 110         


Lys Tyr Glu Tyr Glu Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  138
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  138

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Arg His Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Ser Tyr Gly Ser Thr Asp Tyr Gly Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Pro Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Ala Asp Glu Thr Leu Gly Ala Val Pro Asn Phe Arg Leu His Glu 
            100                 105                 110         


Lys Tyr Glu Tyr Glu Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  139
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  139

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Arg His Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Ser Tyr Gly Ser Thr Asp Tyr Gly Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Ala Asp Glu Thr Leu Gly Ala Val Pro Asn Phe Arg Leu His Glu 
            100                 105                 110         


Lys Tyr Glu Tyr Glu Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  140
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  140

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Arg His Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Ser Tyr Gly Ser Thr Asp Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Ala Asp Glu Thr Leu Gly Ala Val Pro Asn Phe Arg Leu His Glu 
            100                 105                 110         


Lys Tyr Glu Tyr Glu Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  141
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  141

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Arg His Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Ser Tyr Gly Ser Thr Asp Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Pro Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Ala Asp Glu Thr Leu Gly Ala Val Pro Asn Phe Arg Leu His Glu 
            100                 105                 110         


Lys Tyr Glu Tyr Glu Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  142
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  142

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Arg His Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Ser Tyr Gly Ser Thr Asp Tyr Gly Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Ala Asp Glu Thr Leu Gly Ala Val Pro Asn Phe Arg Leu His Glu 
            100                 105                 110         


Lys Tyr Glu Tyr Glu Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  143
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  143

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Arg His Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Ser Tyr Gly Ser Thr Asp Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Ala Asp Glu Thr Leu Gly Ala Val Pro Asn Phe Arg Leu His Glu 
            100                 105                 110         


Lys Tyr Glu Tyr Glu Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  144
<211>  418
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  144

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Arg His Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Ser Tyr Gly Ser Thr Asp Tyr Gly Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn Thr Val Pro Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Ala Asp Glu Thr Leu Gly Ala Val Pro Asn Phe Arg Leu His Glu 
            100                 105                 110         


Lys Tyr Glu Tyr Glu Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
145                 150                 155                 160 


Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
                165                 170                 175     


Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr 
            180                 185                 190         


Phe Arg His Tyr Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu 
        195                 200                 205             


Arg Glu Phe Val Ala Ala Ile Ser Ser Tyr Gly Ser Thr Asp Tyr Gly 
    210                 215                 220                 


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn 
225                 230                 235                 240 


Thr Val Pro Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val 
                245                 250                 255     


Tyr Tyr Cys Ala Ala Ala Asp Glu Thr Leu Gly Ala Val Pro Asn Phe 
            260                 265                 270         


Arg Leu His Glu Lys Tyr Glu Tyr Glu Tyr Trp Gly Gln Gly Thr Leu 
        275                 280                 285             


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val 
    290                 295                 300                 


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Asn Ser Leu 
305                 310                 315                 320 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe Gly Met 
                325                 330                 335     


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser 
            340                 345                 350         


Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val Lys Gly 
        355                 360                 365             


Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr Leu Gln 
    370                 375                 380                 


Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Thr Ile 
385                 390                 395                 400 


Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr Val Ser 
                405                 410                 415     


Ser Ala 
        


<210>  145
<211>  420
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  145

Asp Val Gln Leu Val Glu Ser Gly Gly Lys Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Arg Thr Phe Ser Phe Ser 
            20                  25                  30          


Thr Ser Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Leu Glu 
        35                  40                  45              


Phe Val Ala Ala Ile Asp Trp Ser Asp Phe Asn Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg His Asn Pro Arg Asn Ser 
65                  70                  75                  80  


Val Tyr Leu Gln Leu Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Ala His Ser Glu Thr Arg Gly Gly Thr Arg Tyr Phe Asp 
            100                 105                 110         


Arg Pro Ser Leu Tyr Asn Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
        115                 120                 125             


Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
145                 150                 155                 160 


Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Lys Leu 
                165                 170                 175     


Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Arg 
            180                 185                 190         


Thr Phe Ser Phe Ser Thr Ser Thr Met Gly Trp Phe Arg Gln Ala Pro 
        195                 200                 205             


Gly Lys Glu Leu Glu Phe Val Ala Ala Ile Asp Trp Ser Asp Phe Asn 
    210                 215                 220                 


Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg His 
225                 230                 235                 240 


Asn Pro Arg Asn Ser Val Tyr Leu Gln Leu Asn Ser Leu Lys Pro Glu 
                245                 250                 255     


Asp Thr Ala Val Tyr Tyr Cys Ala Ala His Ser Glu Thr Arg Gly Gly 
            260                 265                 270         


Thr Arg Tyr Phe Asp Arg Pro Ser Leu Tyr Asn Tyr Trp Gly Gln Gly 
        275                 280                 285             


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser 
    290                 295                 300                 


Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Asn 
305                 310                 315                 320 


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 
                325                 330                 335     


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
            340                 345                 350         


Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val 
        355                 360                 365             


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr 
    370                 375                 380                 


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
385                 390                 395                 400 


Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr 
                405                 410                 415     


Val Ser Ser Ala 
            420 


<210>  146
<211>  419
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  146

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Arg His Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Ser Tyr Gly Ser Thr Asp Tyr Gly Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn Thr Val Pro Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Ala Asp Glu Thr Leu Gly Ala Val Pro Asn Phe Arg Leu His Glu 
            100                 105                 110         


Lys Tyr Glu Tyr Glu Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
145                 150                 155                 160 


Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Lys Leu Val 
                165                 170                 175     


Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Arg Thr 
            180                 185                 190         


Phe Ser Phe Ser Thr Ser Thr Met Gly Trp Phe Arg Gln Ala Pro Gly 
        195                 200                 205             


Lys Glu Leu Glu Phe Val Ala Ala Ile Asp Trp Ser Asp Phe Asn Thr 
    210                 215                 220                 


Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg His Asn 
225                 230                 235                 240 


Pro Arg Asn Ser Val Tyr Leu Gln Leu Asn Ser Leu Lys Pro Glu Asp 
                245                 250                 255     


Thr Ala Val Tyr Tyr Cys Ala Ala His Ser Glu Thr Arg Gly Gly Thr 
            260                 265                 270         


Arg Tyr Phe Asp Arg Pro Ser Leu Tyr Asn Tyr Trp Gly Gln Gly Thr 
        275                 280                 285             


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu 
    290                 295                 300                 


Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Asn Ser 
305                 310                 315                 320 


Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe Gly 
                325                 330                 335     


Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser 
            340                 345                 350         


Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val Lys 
        355                 360                 365             


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr Leu 
    370                 375                 380                 


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Thr 
385                 390                 395                 400 


Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr Val 
                405                 410                 415     


Ser Ser Ala 
            


<210>  147
<211>  130
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  147

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Arg Thr Phe Ser Phe Ser 
            20                  25                  30          


Thr Ser Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Leu Glu 
        35                  40                  45              


Phe Val Ala Ala Ile Asp Trp Ser Asp Phe Asn Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg His Asn Pro Arg Asn Ser 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Ala His Ser Glu Thr Arg Gly Gly Thr Arg Tyr Phe Asp 
            100                 105                 110         


Arg Pro Ser Leu Tyr Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val 
        115                 120                 125             


Ser Ser 
    130 


<210>  148
<211>  130
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  148

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Arg Thr Phe Ser Phe Ser 
            20                  25                  30          


Thr Ser Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu 
        35                  40                  45              


Phe Val Ala Ala Ile Asp Trp Ser Asp Phe Asn Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg His Asn Pro Arg Asn Ser 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Ala His Ser Glu Thr Arg Gly Gly Thr Arg Tyr Phe Asp 
            100                 105                 110         


Arg Pro Ser Leu Tyr Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val 
        115                 120                 125             


Ser Ser 
    130 


<210>  149
<211>  130
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  149

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Arg Thr Phe Ser Phe Ser 
            20                  25                  30          


Thr Ser Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Leu Glu 
        35                  40                  45              


Phe Val Ala Ala Ile Asp Trp Ser Asp Phe Asn Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Pro Arg Asn Ser 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Ala His Ser Glu Thr Arg Gly Gly Thr Arg Tyr Phe Asp 
            100                 105                 110         


Arg Pro Ser Leu Tyr Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val 
        115                 120                 125             


Ser Ser 
    130 


<210>  150
<211>  130
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  150

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Arg Thr Phe Ser Phe Ser 
            20                  25                  30          


Thr Ser Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Leu Glu 
        35                  40                  45              


Phe Val Ala Ala Ile Asp Trp Ser Asp Phe Asn Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg His Asn Ser Arg Asn Ser 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Ala His Ser Glu Thr Arg Gly Gly Thr Arg Tyr Phe Asp 
            100                 105                 110         


Arg Pro Ser Leu Tyr Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val 
        115                 120                 125             


Ser Ser 
    130 


<210>  151
<211>  130
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  151

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Arg Thr Phe Ser Phe Ser 
            20                  25                  30          


Thr Ser Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Leu Glu 
        35                  40                  45              


Phe Val Ala Ala Ile Asp Trp Ser Asp Phe Asn Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg His Asn Pro Lys Asn Ser 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Ala His Ser Glu Thr Arg Gly Gly Thr Arg Tyr Phe Asp 
            100                 105                 110         


Arg Pro Ser Leu Tyr Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val 
        115                 120                 125             


Ser Ser 
    130 


<210>  152
<211>  130
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  152

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Arg Thr Phe Ser Phe Ser 
            20                  25                  30          


Thr Ser Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Leu Glu 
        35                  40                  45              


Phe Val Ala Ala Ile Asp Trp Ser Asp Phe Asn Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg His Asn Pro Arg Asn Thr 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Ala His Ser Glu Thr Arg Gly Gly Thr Arg Tyr Phe Asp 
            100                 105                 110         


Arg Pro Ser Leu Tyr Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val 
        115                 120                 125             


Ser Ser 
    130 


<210>  153
<211>  130
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  153

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Arg Thr Phe Ser Phe Ser 
            20                  25                  30          


Thr Ser Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu 
        35                  40                  45              


Phe Val Ala Ala Ile Asp Trp Ser Asp Phe Asn Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Ala His Ser Glu Thr Arg Gly Gly Thr Arg Tyr Phe Asp 
            100                 105                 110         


Arg Pro Ser Leu Tyr Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val 
        115                 120                 125             


Ser Ser 
    130 


<210>  154
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  154

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Arg His Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Ser Tyr Gly Ser Thr Asp Tyr Gly Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Val Pro Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Ala Asp Glu Thr Leu Gly Ala Val Pro Asn Phe Arg Leu His Glu 
            100                 105                 110         


Lys Tyr Glu Tyr Glu Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  155
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  155

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Arg His Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Ser Tyr Gly Ser Thr Asp Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Val Pro Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Ala Asp Glu Thr Leu Gly Ala Val Pro Asn Phe Arg Leu His Glu 
            100                 105                 110         


Lys Tyr Glu Tyr Glu Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  156
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  156

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Arg His Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Ser Tyr Gly Ser Thr Asp Tyr Gly Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Pro Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Ala Asp Glu Thr Leu Gly Ala Val Pro Asn Phe Arg Leu His Glu 
            100                 105                 110         


Lys Tyr Glu Tyr Glu Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  157
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  157

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Arg His Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Ser Tyr Gly Ser Thr Asp Tyr Gly Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Ala Asp Glu Thr Leu Gly Ala Val Pro Asn Phe Arg Leu His Glu 
            100                 105                 110         


Lys Tyr Glu Tyr Glu Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  158
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  158

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Arg His Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Ser Tyr Gly Ser Thr Asp Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Ala Asp Glu Thr Leu Gly Ala Val Pro Asn Phe Arg Leu His Glu 
            100                 105                 110         


Lys Tyr Glu Tyr Glu Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  159
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  159

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Arg His Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Ser Tyr Gly Ser Thr Asp Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Pro Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Ala Asp Glu Thr Leu Gly Ala Val Pro Asn Phe Arg Leu His Glu 
            100                 105                 110         


Lys Tyr Glu Tyr Glu Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  160
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  160

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Arg His Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Ser Tyr Gly Ser Thr Asp Tyr Gly Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Ala Asp Glu Thr Leu Gly Ala Val Pro Asn Phe Arg Leu His Glu 
            100                 105                 110         


Lys Tyr Glu Tyr Glu Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  161
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  161

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Arg His Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Ser Tyr Gly Ser Thr Asp Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Ala Asp Glu Thr Leu Gly Ala Val Pro Asn Phe Arg Leu His Glu 
            100                 105                 110         


Lys Tyr Glu Tyr Glu Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  162
<211>  131
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  162

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Arg Thr Phe Ser Phe Ser 
            20                  25                  30          


Thr Ser Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Leu Glu 
        35                  40                  45              


Phe Val Ala Ala Ile Asp Trp Ser Asp Phe Asn Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg His Asn Pro Arg Asn Ser 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Ala His Ser Glu Thr Arg Gly Gly Thr Arg Tyr Phe Asp 
            100                 105                 110         


Arg Pro Ser Leu Tyr Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val 
        115                 120                 125             


Ser Ser Ala 
    130     


<210>  163
<211>  131
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  163

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Arg Thr Phe Ser Phe Ser 
            20                  25                  30          


Thr Ser Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu 
        35                  40                  45              


Phe Val Ala Ala Ile Asp Trp Ser Asp Phe Asn Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg His Asn Pro Arg Asn Ser 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Ala His Ser Glu Thr Arg Gly Gly Thr Arg Tyr Phe Asp 
            100                 105                 110         


Arg Pro Ser Leu Tyr Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val 
        115                 120                 125             


Ser Ser Ala 
    130     


<210>  164
<211>  131
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  164

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Arg Thr Phe Ser Phe Ser 
            20                  25                  30          


Thr Ser Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Leu Glu 
        35                  40                  45              


Phe Val Ala Ala Ile Asp Trp Ser Asp Phe Asn Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Pro Arg Asn Ser 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Ala His Ser Glu Thr Arg Gly Gly Thr Arg Tyr Phe Asp 
            100                 105                 110         


Arg Pro Ser Leu Tyr Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val 
        115                 120                 125             


Ser Ser Ala 
    130     


<210>  165
<211>  131
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  165

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Arg Thr Phe Ser Phe Ser 
            20                  25                  30          


Thr Ser Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Leu Glu 
        35                  40                  45              


Phe Val Ala Ala Ile Asp Trp Ser Asp Phe Asn Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg His Asn Ser Arg Asn Ser 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Ala His Ser Glu Thr Arg Gly Gly Thr Arg Tyr Phe Asp 
            100                 105                 110         


Arg Pro Ser Leu Tyr Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val 
        115                 120                 125             


Ser Ser Ala 
    130     


<210>  166
<211>  131
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  166

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Arg Thr Phe Ser Phe Ser 
            20                  25                  30          


Thr Ser Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Leu Glu 
        35                  40                  45              


Phe Val Ala Ala Ile Asp Trp Ser Asp Phe Asn Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg His Asn Pro Lys Asn Ser 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Ala His Ser Glu Thr Arg Gly Gly Thr Arg Tyr Phe Asp 
            100                 105                 110         


Arg Pro Ser Leu Tyr Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val 
        115                 120                 125             


Ser Ser Ala 
    130     


<210>  167
<211>  131
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  167

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Arg Thr Phe Ser Phe Ser 
            20                  25                  30          


Thr Ser Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Leu Glu 
        35                  40                  45              


Phe Val Ala Ala Ile Asp Trp Ser Asp Phe Asn Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg His Asn Pro Arg Asn Thr 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Ala His Ser Glu Thr Arg Gly Gly Thr Arg Tyr Phe Asp 
            100                 105                 110         


Arg Pro Ser Leu Tyr Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val 
        115                 120                 125             


Ser Ser Ala 
    130     


<210>  168
<211>  131
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  168

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Arg Thr Phe Ser Phe Ser 
            20                  25                  30          


Thr Ser Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu 
        35                  40                  45              


Phe Val Ala Ala Ile Asp Trp Ser Asp Phe Asn Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Ala His Ser Glu Thr Arg Gly Gly Thr Arg Tyr Phe Asp 
            100                 105                 110         


Arg Pro Ser Leu Tyr Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val 
        115                 120                 125             


Ser Ser Ala 
    130     


<210>  169
<211>  130
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  169

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Arg His Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Ser Tyr Gly Ser Thr Asp Tyr Gly Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Val Pro Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Ala Asp Glu Thr Leu Gly Ala Val Pro Asn Phe Arg Leu His Glu 
            100                 105                 110         


Lys Tyr Glu Tyr Glu Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        115                 120                 125             


Ser Ala 
    130 


<210>  170
<211>  130
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  170

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Arg His Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Ser Tyr Gly Ser Thr Asp Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Val Pro Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Ala Asp Glu Thr Leu Gly Ala Val Pro Asn Phe Arg Leu His Glu 
            100                 105                 110         


Lys Tyr Glu Tyr Glu Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        115                 120                 125             


Ser Ala 
    130 


<210>  171
<211>  130
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  171

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Arg His Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Ser Tyr Gly Ser Thr Asp Tyr Gly Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Pro Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Ala Asp Glu Thr Leu Gly Ala Val Pro Asn Phe Arg Leu His Glu 
            100                 105                 110         


Lys Tyr Glu Tyr Glu Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        115                 120                 125             


Ser Ala 
    130 


<210>  172
<211>  130
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  172

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Arg His Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Ser Tyr Gly Ser Thr Asp Tyr Gly Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Ala Asp Glu Thr Leu Gly Ala Val Pro Asn Phe Arg Leu His Glu 
            100                 105                 110         


Lys Tyr Glu Tyr Glu Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        115                 120                 125             


Ser Ala 
    130 


<210>  173
<211>  130
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  173

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Arg His Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Ser Tyr Gly Ser Thr Asp Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Ala Asp Glu Thr Leu Gly Ala Val Pro Asn Phe Arg Leu His Glu 
            100                 105                 110         


Lys Tyr Glu Tyr Glu Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        115                 120                 125             


Ser Ala 
    130 


<210>  174
<211>  130
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  174

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Arg His Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Ser Tyr Gly Ser Thr Asp Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Pro Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Ala Asp Glu Thr Leu Gly Ala Val Pro Asn Phe Arg Leu His Glu 
            100                 105                 110         


Lys Tyr Glu Tyr Glu Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        115                 120                 125             


Ser Ala 
    130 


<210>  175
<211>  130
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  175

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Arg His Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Ser Tyr Gly Ser Thr Asp Tyr Gly Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Ala Asp Glu Thr Leu Gly Ala Val Pro Asn Phe Arg Leu His Glu 
            100                 105                 110         


Lys Tyr Glu Tyr Glu Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        115                 120                 125             


Ser Ala 
    130 


<210>  176
<211>  130
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR Sequence

<400>  176

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Arg His Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Ser Tyr Gly Ser Thr Asp Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Ala Asp Glu Thr Leu Gly Ala Val Pro Asn Phe Arg Leu His Glu 
            100                 105                 110         


Lys Tyr Glu Tyr Glu Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        115                 120                 125             


Ser Ala 
    130 


<210>  177
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-Terminal tag

<400>  177

Gly Gly Gly Cys 
1               


