                         SEQUENCE LISTING

<110>  Spiber Technologies AB
 
<120>  CHARGE-REVERSED N-TERMINAL SPIDER SILK PROTEIN DOMAIN AND USES 
       THEREOF

<130>  PC-21086278

<150>  EP 15194623
<151>  2015-11-13

<150>  EP 16186679
<151>  2016-08-31

<150>  EP 16193082
<151>  2016-10-10

<160>  108   

<170>  PatentIn version 3.5

<210>  1
<211>  137
<212>  PRT
<213>  Euprosthenops australis


<220>
<221>  VARIANT
<222>  (40)..(40)
<223>  Arg (R)

<220>
<221>  VARIANT
<222>  (40)..(40)
<223>  His (H)

<220>
<221>  MUTAGEN
<222>  (40)..(40)

<220>
<221>  VARIANT
<222>  (65)..(65)
<223>  Glu (E)

<220>
<221>  MUTAGEN
<222>  (65)..(65)

<400>  1

Gly Ser Gly Asn Ser His Thr Thr Pro Trp Thr Asn Pro Gly Leu Ala 
1               5                   10                  15      


Glu Asn Phe Met Asn Ser Phe Met Gln Gly Leu Ser Ser Met Pro Gly 
            20                  25                  30          


Phe Thr Ala Ser Gln Leu Asp Lys Met Ser Thr Ile Ala Gln Ser Met 
        35                  40                  45              


Val Gln Ser Ile Gln Ser Leu Ala Ala Gln Gly Arg Thr Ser Pro Asn 
    50                  55                  60                  


Asp Leu Gln Ala Leu Asn Met Ala Phe Ala Ser Ser Met Ala Glu Ile 
65                  70                  75                  80  


Ala Ala Ser Glu Glu Gly Gly Gly Ser Leu Ser Thr Lys Thr Ser Ser 
                85                  90                  95      


Ile Ala Ser Ala Met Ser Asn Ala Phe Leu Gln Thr Thr Gly Val Val 
            100                 105                 110         


Asn Gln Pro Phe Ile Asn Glu Ile Thr Gln Leu Val Ser Met Phe Ala 
        115                 120                 125             


Gln Ala Gly Met Asn Asp Val Ser Ala 
    130                 135         


<210>  2
<211>  133
<212>  PRT
<213>  Euprosthenops australis


<220>
<221>  MUTAGEN
<222>  (36)..(36)

<220>
<221>  MUTAGEN
<222>  (61)..(61)

<400>  2

Ser His Thr Thr Pro Trp Thr Asn Pro Gly Leu Ala Glu Asn Phe Met 
1               5                   10                  15      


Asn Ser Phe Met Gln Gly Leu Ser Ser Met Pro Gly Phe Thr Ala Ser 
            20                  25                  30          


Gln Leu Asp Lys Met Ser Thr Ile Ala Gln Ser Met Val Gln Ser Ile 
        35                  40                  45              


Gln Ser Leu Ala Ala Gln Gly Arg Thr Ser Pro Asn Asp Leu Gln Ala 
    50                  55                  60                  


Leu Asn Met Ala Phe Ala Ser Ser Met Ala Glu Ile Ala Ala Ser Glu 
65                  70                  75                  80  


Glu Gly Gly Gly Ser Leu Ser Thr Lys Thr Ser Ser Ile Ala Ser Ala 
                85                  90                  95      


Met Ser Asn Ala Phe Leu Gln Thr Thr Gly Val Val Asn Gln Pro Phe 
            100                 105                 110         


Ile Asn Glu Ile Thr Gln Leu Val Ser Met Phe Ala Gln Ala Gly Met 
        115                 120                 125             


Asn Asp Val Ser Ala 
    130             


<210>  3
<211>  133
<212>  PRT
<213>  Euprosthenops australis


<220>
<221>  MUTAGEN
<222>  (36)..(36)

<220>
<221>  MUTAGEN
<222>  (61)..(61)

<400>  3

Ser His Thr Thr Pro Trp Thr Asn Pro Gly Leu Ala Glu Asn Phe Met 
1               5                   10                  15      


Asn Ser Phe Met Gln Gly Leu Ser Ser Met Pro Gly Phe Thr Ala Ser 
            20                  25                  30          


Gln Leu Asp Arg Met Ser Thr Ile Ala Gln Ser Met Val Gln Ser Ile 
        35                  40                  45              


Gln Ser Leu Ala Ala Gln Gly Arg Thr Ser Pro Asn Asp Leu Gln Ala 
    50                  55                  60                  


Leu Asn Met Ala Phe Ala Ser Ser Met Ala Glu Ile Ala Ala Ser Glu 
65                  70                  75                  80  


Glu Gly Gly Gly Ser Leu Ser Thr Lys Thr Ser Ser Ile Ala Ser Ala 
                85                  90                  95      


Met Ser Asn Ala Phe Leu Gln Thr Thr Gly Val Val Asn Gln Pro Phe 
            100                 105                 110         


Ile Asn Glu Ile Thr Gln Leu Val Ser Met Phe Ala Gln Ala Gly Met 
        115                 120                 125             


Asn Asp Val Ser Ala 
    130             


<210>  4
<211>  133
<212>  PRT
<213>  Euprosthenops australis


<220>
<221>  MUTAGEN
<222>  (36)..(36)

<220>
<221>  MUTAGEN
<222>  (61)..(61)

<400>  4

Ser His Thr Thr Pro Trp Thr Asn Pro Gly Leu Ala Glu Asn Phe Met 
1               5                   10                  15      


Asn Ser Phe Met Gln Gly Leu Ser Ser Met Pro Gly Phe Thr Ala Ser 
            20                  25                  30          


Gln Leu Asp His Met Ser Thr Ile Ala Gln Ser Met Val Gln Ser Ile 
        35                  40                  45              


Gln Ser Leu Ala Ala Gln Gly Arg Thr Ser Pro Asn Asp Leu Gln Ala 
    50                  55                  60                  


Leu Asn Met Ala Phe Ala Ser Ser Met Ala Glu Ile Ala Ala Ser Glu 
65                  70                  75                  80  


Glu Gly Gly Gly Ser Leu Ser Thr Lys Thr Ser Ser Ile Ala Ser Ala 
                85                  90                  95      


Met Ser Asn Ala Phe Leu Gln Thr Thr Gly Val Val Asn Gln Pro Phe 
            100                 105                 110         


Ile Asn Glu Ile Thr Gln Leu Val Ser Met Phe Ala Gln Ala Gly Met 
        115                 120                 125             


Asn Asp Val Ser Ala 
    130             


<210>  5
<211>  133
<212>  PRT
<213>  Euprosthenops australis


<220>
<221>  MUTAGEN
<222>  (36)..(36)

<220>
<221>  MUTAGEN
<222>  (61)..(61)

<400>  5

Ser His Thr Thr Pro Trp Thr Asn Pro Gly Leu Ala Glu Asn Phe Met 
1               5                   10                  15      


Asn Ser Phe Met Gln Gly Leu Ser Ser Met Pro Gly Phe Thr Ala Ser 
            20                  25                  30          


Gln Leu Asp Lys Met Ser Thr Ile Ala Gln Ser Met Val Gln Ser Ile 
        35                  40                  45              


Gln Ser Leu Ala Ala Gln Gly Arg Thr Ser Pro Asn Glu Leu Gln Ala 
    50                  55                  60                  


Leu Asn Met Ala Phe Ala Ser Ser Met Ala Glu Ile Ala Ala Ser Glu 
65                  70                  75                  80  


Glu Gly Gly Gly Ser Leu Ser Thr Lys Thr Ser Ser Ile Ala Ser Ala 
                85                  90                  95      


Met Ser Asn Ala Phe Leu Gln Thr Thr Gly Val Val Asn Gln Pro Phe 
            100                 105                 110         


Ile Asn Glu Ile Thr Gln Leu Val Ser Met Phe Ala Gln Ala Gly Met 
        115                 120                 125             


Asn Asp Val Ser Ala 
    130             


<210>  6
<211>  133
<212>  PRT
<213>  Euprosthenops australis


<220>
<221>  MUTAGEN
<222>  (36)..(36)

<220>
<221>  MUTAGEN
<222>  (61)..(61)

<400>  6

Ser His Thr Thr Pro Trp Thr Asn Pro Gly Leu Ala Glu Asn Phe Met 
1               5                   10                  15      


Asn Ser Phe Met Gln Gly Leu Ser Ser Met Pro Gly Phe Thr Ala Ser 
            20                  25                  30          


Gln Leu Asp Arg Met Ser Thr Ile Ala Gln Ser Met Val Gln Ser Ile 
        35                  40                  45              


Gln Ser Leu Ala Ala Gln Gly Arg Thr Ser Pro Asn Glu Leu Gln Ala 
    50                  55                  60                  


Leu Asn Met Ala Phe Ala Ser Ser Met Ala Glu Ile Ala Ala Ser Glu 
65                  70                  75                  80  


Glu Gly Gly Gly Ser Leu Ser Thr Lys Thr Ser Ser Ile Ala Ser Ala 
                85                  90                  95      


Met Ser Asn Ala Phe Leu Gln Thr Thr Gly Val Val Asn Gln Pro Phe 
            100                 105                 110         


Ile Asn Glu Ile Thr Gln Leu Val Ser Met Phe Ala Gln Ala Gly Met 
        115                 120                 125             


Asn Asp Val Ser Ala 
    130             


<210>  7
<211>  133
<212>  PRT
<213>  Euprosthenops australis


<220>
<221>  MUTAGEN
<222>  (36)..(36)

<220>
<221>  MUTAGEN
<222>  (61)..(61)

<400>  7

Ser His Thr Thr Pro Trp Thr Asn Pro Gly Leu Ala Glu Asn Phe Met 
1               5                   10                  15      


Asn Ser Phe Met Gln Gly Leu Ser Ser Met Pro Gly Phe Thr Ala Ser 
            20                  25                  30          


Gln Leu Asp His Met Ser Thr Ile Ala Gln Ser Met Val Gln Ser Ile 
        35                  40                  45              


Gln Ser Leu Ala Ala Gln Gly Arg Thr Ser Pro Asn Glu Leu Gln Ala 
    50                  55                  60                  


Leu Asn Met Ala Phe Ala Ser Ser Met Ala Glu Ile Ala Ala Ser Glu 
65                  70                  75                  80  


Glu Gly Gly Gly Ser Leu Ser Thr Lys Thr Ser Ser Ile Ala Ser Ala 
                85                  90                  95      


Met Ser Asn Ala Phe Leu Gln Thr Thr Gly Val Val Asn Gln Pro Phe 
            100                 105                 110         


Ile Asn Glu Ile Thr Gln Leu Val Ser Met Phe Ala Gln Ala Gly Met 
        115                 120                 125             


Asn Asp Val Ser Ala 
    130             


<210>  8
<211>  399
<212>  DNA
<213>  Euprosthenops australis

<400>  8
tcacacacta caccatggac aaacccagga ctcgcagaaa acttcatgaa cagtttcatg       60

caaggcctga gctcgatgcc aggtttcacg gcaagccaat tggataagat gtcaaccatc      120

gcacaatcca tggtacagtc aatacaatcc ttggcggcac aaggcaggac atcaccgaat      180

gacctgcagg cccttaacat ggcttttgca tcttcgatgg cagaaatcgc ggcatccgaa      240

gaaggagggg gaagcctttc caccaaaact agctctatag ccagtgcaat gtccaacgcg      300

tttctgcaaa caactggagt ggtaaaccaa ccgttcataa atgaaataac tcagctcgtt      360

agcatgtttg ctcaagcagg tatgaatgat gtcagtgct                             399


<210>  9
<211>  137
<212>  PRT
<213>  Euprosthenops australis


<220>
<221>  VARIANT
<222>  (6)..(6)
<223>  deletion (deltaHis)

<400>  9

Gly Ser Gly Asn Ser His Thr Thr Pro Trp Thr Asn Pro Gly Leu Ala 
1               5                   10                  15      


Glu Asn Phe Met Asn Ser Phe Met Gln Gly Leu Ser Ser Met Pro Gly 
            20                  25                  30          


Phe Thr Ala Ser Gln Leu Asp Asp Met Ser Thr Ile Ala Gln Ser Met 
        35                  40                  45              


Val Gln Ser Ile Gln Ser Leu Ala Ala Gln Gly Arg Thr Ser Pro Asn 
    50                  55                  60                  


Lys Leu Gln Ala Leu Asn Met Ala Phe Ala Ser Ser Met Ala Glu Ile 
65                  70                  75                  80  


Ala Ala Ser Glu Glu Gly Gly Gly Ser Leu Ser Thr Lys Thr Ser Ser 
                85                  90                  95      


Ile Ala Ser Ala Met Ser Asn Ala Phe Leu Gln Thr Thr Gly Val Val 
            100                 105                 110         


Asn Gln Pro Phe Ile Asn Glu Ile Thr Gln Leu Val Ser Met Phe Ala 
        115                 120                 125             


Gln Ala Gly Met Asn Asp Val Ser Ala 
    130                 135         


<210>  10
<211>  131
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus sequence derived from spidroin NT fragments


<220>
<221>  VARIANT
<222>  (20)..(20)
<223>  Leu

<220>
<221>  VARIANT
<222>  (42)..(42)
<223>  Asn

<220>
<221>  VARIANT
<222>  (42)..(42)
<223>  Gln

<220>
<221>  VARIANT
<222>  (50)..(50)
<223>  Ser

<220>
<221>  VARIANT
<222>  (50)..(50)
<223>  Lys

<220>
<221>  VARIANT
<222>  (56)..(56)
<223>  Arg

<220>
<221>  VARIANT
<222>  (84)..(84)
<223>  Leu

<220>
<221>  VARIANT
<222>  (114)..(114)
<223>  Ser

<220>
<221>  VARIANT
<222>  (121)..(121)
<223>  Asn

<220>
<221>  VARIANT
<222>  (123)..(123)
<223>  Leu

<220>
<221>  VARIANT
<222>  (124)..(124)
<223>  Ser

<400>  10

Gln Ala Asn Thr Pro Trp Ser Ser Pro Asn Leu Ala Asp Ala Phe Ile 
1               5                   10                  15      


Asn Ser Phe Met Ser Ala Ala Ser Ser Ser Gly Ala Phe Ser Ala Asp 
            20                  25                  30          


Gln Leu Asp Asp Met Ser Thr Ile Gly Asp Thr Leu Met Ser Ala Met 
        35                  40                  45              


Asp Asn Met Gly Arg Ser Gly Lys Ser Thr Lys Ser Lys Leu Gln Ala 
    50                  55                  60                  


Leu Asn Met Ala Phe Ala Ser Ser Met Ala Glu Ile Ala Ala Ala Glu 
65                  70                  75                  80  


Ser Gly Gly Gly Ser Val Gly Val Lys Thr Asn Ala Ile Ser Asp Ala 
                85                  90                  95      


Leu Ser Ser Ala Phe Tyr Gln Thr Thr Gly Ser Val Asn Pro Gln Phe 
            100                 105                 110         


Val Asn Glu Ile Arg Ser Leu Ile Gly Met Phe Ala Gln Ala Ser Ala 
        115                 120                 125             


Asn Glu Val 
    130     


<210>  11
<211>  133
<212>  PRT
<213>  Euprosthenops australis

<400>  11

Ser His Thr Thr Pro Trp Thr Asn Pro Gly Leu Ala Glu Asn Phe Met 
1               5                   10                  15      


Asn Ser Phe Met Gln Gly Leu Ser Ser Met Pro Gly Phe Thr Ala Ser 
            20                  25                  30          


Gln Leu Asp Asp Met Ser Thr Ile Ala Gln Ser Met Val Gln Ser Ile 
        35                  40                  45              


Gln Ser Leu Ala Ala Gln Gly Arg Thr Ser Pro Asn Lys Leu Gln Ala 
    50                  55                  60                  


Leu Asn Met Ala Phe Ala Ser Ser Met Ala Glu Ile Ala Ala Ser Glu 
65                  70                  75                  80  


Glu Gly Gly Gly Ser Leu Ser Thr Lys Thr Ser Ser Ile Ala Ser Ala 
                85                  90                  95      


Met Ser Asn Ala Phe Leu Gln Thr Thr Gly Val Val Asn Gln Pro Phe 
            100                 105                 110         


Ile Asn Glu Ile Thr Gln Leu Val Ser Met Phe Ala Gln Ala Gly Met 
        115                 120                 125             


Asn Asp Val Ser Ala 
    130             


<210>  12
<211>  399
<212>  DNA
<213>  Euprosthenops australis

<400>  12
tcacacacta caccatggac aaacccagga ctcgcagaaa acttcatgaa cagtttcatg       60

caaggcctga gctcgatgcc aggtttcacg gcaagccaat tggatgatat gtcaaccatc      120

gcacaatcca tggtacagtc aatacaatcc ttggcggcac aaggcaggac atcaccgaat      180

aagctgcagg cccttaacat ggcttttgca tcttcgatgg cagaaatcgc ggcatccgaa      240

gaaggagggg gaagcctttc caccaaaact agctctatag ccagtgcaat gtccaacgcg      300

tttctgcaaa caactggagt ggtaaaccaa ccgttcataa atgaaataac tcagctcgtt      360

agcatgtttg ctcaagcagg tatgaatgat gtcagtgct                             399


<210>  13
<211>  131
<212>  PRT
<213>  Euprosthenops australis

<400>  13

Ser His Thr Thr Pro Trp Thr Asn Pro Gly Leu Ala Glu Asn Phe Met 
1               5                   10                  15      


Asn Ser Phe Met Gln Gly Leu Ser Ser Met Pro Gly Phe Thr Ala Ser 
            20                  25                  30          


Gln Leu Asp Asp Met Ser Thr Ile Ala Gln Ser Met Val Gln Ser Ile 
        35                  40                  45              


Gln Ser Leu Ala Ala Gln Gly Arg Thr Ser Pro Asn Lys Leu Gln Ala 
    50                  55                  60                  


Leu Asn Met Ala Phe Ala Ser Ser Met Ala Glu Ile Ala Ala Ser Glu 
65                  70                  75                  80  


Glu Gly Gly Gly Ser Leu Ser Thr Lys Thr Ser Ser Ile Ala Ser Ala 
                85                  90                  95      


Met Ser Asn Ala Phe Leu Gln Thr Thr Gly Val Val Asn Gln Pro Phe 
            100                 105                 110         


Ile Asn Glu Ile Thr Gln Leu Val Ser Met Phe Ala Gln Ala Gly Met 
        115                 120                 125             


Asn Asp Val 
    130     


<210>  14
<211>  127
<212>  PRT
<213>  Latrodectus geometricus

<400>  14

Gln Ala Asn Thr Pro Trp Ser Ser Lys Gln Asn Ala Asp Ala Phe Ile 
1               5                   10                  15      


Ser Ala Phe Met Thr Ala Ala Ser Gln Ser Gly Ala Phe Ser Ser Asp 
            20                  25                  30          


Gln Ile Asp Asp Met Ser Val Ile Ser Asn Thr Leu Met Ala Ala Met 
        35                  40                  45              


Asp Asn Met Gly Gly Arg Ile Thr Pro Ser Lys Leu Gln Ala Leu Asp 
    50                  55                  60                  


Met Ala Phe Ala Ser Ser Val Ala Glu Ile Ala Ala Val Glu Gly Gln 
65                  70                  75                  80  


Asn Ile Gly Val Thr Thr Asn Ala Ile Ser Asp Ala Leu Thr Ser Ala 
                85                  90                  95      


Phe Tyr Gln Thr Thr Gly Val Val Asn Asn Lys Phe Ile Ser Glu Ile 
            100                 105                 110         


Arg Ser Leu Ile Asn Met Phe Ala Gln Ala Ser Ala Asn Asp Val 
        115                 120                 125         


<210>  15
<211>  127
<212>  PRT
<213>  Latrodectus hesperus

<400>  15

Gln Ala Asn Thr Pro Trp Ser Ser Lys Ala Asn Ala Asp Ala Phe Ile 
1               5                   10                  15      


Asn Ser Phe Ile Ser Ala Ala Ser Asn Thr Gly Ser Phe Ser Gln Asp 
            20                  25                  30          


Gln Met Glu Asp Met Ser Leu Ile Gly Asn Thr Leu Met Ala Ala Met 
        35                  40                  45              


Asp Asn Met Gly Gly Arg Ile Thr Pro Ser Lys Leu Gln Ala Leu Asp 
    50                  55                  60                  


Met Ala Phe Ala Ser Ser Val Ala Glu Ile Ala Ala Ser Glu Gly Gly 
65                  70                  75                  80  


Asp Leu Gly Val Thr Thr Asn Ala Ile Ala Asp Ala Leu Thr Ser Ala 
                85                  90                  95      


Phe Tyr Gln Thr Thr Gly Val Val Asn Ser Arg Phe Ile Ser Glu Ile 
            100                 105                 110         


Arg Ser Leu Ile Gly Met Phe Ala Gln Ala Ser Ala Asn Asp Val 
        115                 120                 125         


<210>  16
<211>  130
<212>  PRT
<213>  Nephila clavipes

<400>  16

Gln Asn Thr Pro Trp Ser Ser Thr Glu Leu Ala Asp Ala Phe Ile Asn 
1               5                   10                  15      


Ala Phe Met Asn Glu Ala Gly Arg Thr Gly Ala Phe Thr Ala Asp Gln 
            20                  25                  30          


Leu Asp Asp Met Ser Thr Ile Gly Asp Thr Ile Lys Thr Ala Met Asp 
        35                  40                  45              


Lys Met Ala Arg Ser Asn Lys Ser Ser Lys Gly Lys Leu Gln Ala Leu 
    50                  55                  60                  


Asn Met Ala Phe Ala Ser Ser Met Ala Glu Ile Ala Ala Val Glu Gln 
65                  70                  75                  80  


Gly Gly Leu Ser Val Asp Ala Lys Thr Asn Ala Ile Ala Asp Ser Leu 
                85                  90                  95      


Asn Ser Ala Phe Tyr Gln Thr Thr Gly Ala Ala Asn Pro Gln Phe Val 
            100                 105                 110         


Asn Glu Ile Arg Ser Leu Ile Asn Met Phe Ala Gln Ser Ser Ala Asn 
        115                 120                 125             


Glu Val 
    130 


<210>  17
<211>  131
<212>  PRT
<213>  Argiope trifasciata

<400>  17

Gln Gly Ala Thr Pro Trp Glu Asn Ser Gln Leu Ala Glu Ser Phe Ile 
1               5                   10                  15      


Ser Arg Phe Leu Arg Phe Ile Gly Gln Ser Gly Ala Phe Ser Pro Asn 
            20                  25                  30          


Gln Leu Asp Asp Met Ser Ser Ile Gly Asp Thr Leu Lys Thr Ala Ile 
        35                  40                  45              


Glu Lys Met Ala Gln Ser Arg Lys Ser Ser Lys Ser Lys Leu Gln Ala 
    50                  55                  60                  


Leu Asn Met Ala Phe Ala Ser Ser Met Ala Glu Ile Ala Val Ala Glu 
65                  70                  75                  80  


Gln Gly Gly Leu Ser Leu Glu Ala Lys Thr Asn Ala Ile Ala Ser Ala 
                85                  90                  95      


Leu Ser Ala Ala Phe Leu Glu Thr Thr Gly Tyr Val Asn Gln Gln Phe 
            100                 105                 110         


Val Asn Glu Ile Lys Thr Leu Ile Phe Met Ile Ala Gln Ala Ser Ser 
        115                 120                 125             


Asn Glu Ile 
    130     


<210>  18
<211>  124
<212>  PRT
<213>  Latrodectus geometricus

<400>  18

Leu Arg Trp Ser Ser Lys Asp Asn Ala Asp Arg Phe Ile Asn Ala Phe 
1               5                   10                  15      


Leu Gln Ala Ala Ser Asn Ser Gly Ala Phe Ser Ser Asp Gln Val Asp 
            20                  25                  30          


Asp Met Ser Val Ile Gly Asn Thr Leu Met Thr Ala Met Asp Asn Met 
        35                  40                  45              


Gly Gly Arg Ile Thr Pro Ser Lys Leu Gln Ala Leu Asp Met Ala Phe 
    50                  55                  60                  


Ala Ser Ser Val Ala Glu Ile Ala Val Ala Asp Gly Gln Asn Val Gly 
65                  70                  75                  80  


Gly Ala Thr Asn Ala Ile Ser Asn Ala Leu Arg Ser Ala Phe Tyr Gln 
                85                  90                  95      


Thr Thr Gly Val Val Asn Asn Gln Phe Ile Ser Glu Ile Ser Asn Leu 
            100                 105                 110         


Ile Asn Met Phe Ala Gln Val Ser Ala Asn Glu Val 
        115                 120                 


<210>  19
<211>  127
<212>  PRT
<213>  Latrodectus hesperus

<400>  19

Gln Ala Asn Thr Pro Trp Ser Ser Lys Glu Asn Ala Asp Ala Phe Ile 
1               5                   10                  15      


Gly Ala Phe Met Asn Ala Ala Ser Gln Ser Gly Ala Phe Ser Ser Asp 
            20                  25                  30          


Gln Ile Asp Asp Met Ser Val Ile Ser Asn Thr Leu Met Ala Ala Met 
        35                  40                  45              


Asp Asn Met Gly Gly Arg Ile Thr Gln Ser Lys Leu Gln Ala Leu Asp 
    50                  55                  60                  


Met Ala Phe Ala Ser Ser Val Ala Glu Ile Ala Val Ala Asp Gly Gln 
65                  70                  75                  80  


Asn Val Gly Ala Ala Thr Asn Ala Ile Ser Asp Ala Leu Arg Ser Ala 
                85                  90                  95      


Phe Tyr Gln Thr Thr Gly Val Val Asn Asn Gln Phe Ile Thr Gly Ile 
            100                 105                 110         


Ser Ser Leu Ile Gly Met Phe Ala Gln Val Ser Gly Asn Glu Val 
        115                 120                 125         


<210>  20
<211>  131
<212>  PRT
<213>  Nephila inaurata madagascariensis

<400>  20

Gln Ala Asn Thr Pro Trp Ser Asp Thr Ala Thr Ala Asp Ala Phe Ile 
1               5                   10                  15      


Gln Asn Phe Leu Gly Ala Val Ser Gly Ser Gly Ala Phe Thr Pro Asp 
            20                  25                  30          


Gln Leu Asp Asp Met Ser Thr Val Gly Asp Thr Ile Met Ser Ala Met 
        35                  40                  45              


Asp Lys Met Ala Arg Ser Asn Lys Ser Ser Lys Ser Lys Leu Gln Ala 
    50                  55                  60                  


Leu Asn Met Ala Phe Ala Ser Ser Met Ala Glu Ile Ala Ala Val Glu 
65                  70                  75                  80  


Gln Gly Gly Gln Ser Met Asp Val Lys Thr Asn Ala Ile Ala Asn Ala 
                85                  90                  95      


Leu Asp Ser Ala Phe Tyr Met Thr Thr Gly Ser Thr Asn Gln Gln Phe 
            100                 105                 110         


Val Asn Glu Met Arg Ser Leu Ile Asn Met Leu Ser Ala Ala Ala Val 
        115                 120                 125             


Asn Glu Val 
    130     


<210>  21
<211>  131
<212>  PRT
<213>  Nephila clavipes

<400>  21

Gln Ala Arg Ser Pro Trp Ser Asp Thr Ala Thr Ala Asp Ala Phe Ile 
1               5                   10                  15      


Gln Asn Phe Leu Ala Ala Val Ser Gly Ser Gly Ala Phe Thr Ser Asp 
            20                  25                  30          


Gln Leu Asp Asp Met Ser Thr Ile Gly Asp Thr Ile Met Ser Ala Met 
        35                  40                  45              


Asp Lys Met Ala Arg Ser Asn Lys Ser Ser Gln His Lys Leu Gln Ala 
    50                  55                  60                  


Leu Asn Met Ala Phe Ala Ser Ser Met Ala Glu Ile Ala Ala Val Glu 
65                  70                  75                  80  


Gln Gly Gly Met Ser Met Ala Val Lys Thr Asn Ala Ile Val Asp Gly 
                85                  90                  95      


Leu Asn Ser Ala Phe Tyr Met Thr Thr Gly Ala Ala Asn Pro Gln Phe 
            100                 105                 110         


Val Asn Glu Met Arg Ser Leu Ile Ser Met Ile Ser Ala Ala Ser Ala 
        115                 120                 125             


Asn Glu Val 
    130     


<210>  22
<211>  129
<212>  PRT
<213>  Argiope bruennichi

<400>  22

Ala Val Pro Ser Val Phe Ser Ser Pro Asn Leu Ala Ser Gly Phe Leu 
1               5                   10                  15      


Gln Cys Leu Thr Phe Gly Ile Gly Asn Ser Pro Ala Phe Pro Thr Gln 
            20                  25                  30          


Glu Gln Gln Asp Leu Asp Ala Ile Ala Gln Val Ile Leu Asn Ala Val 
        35                  40                  45              


Ser Ser Asn Thr Gly Ala Thr Ala Ser Ala Arg Ala Gln Ala Leu Ser 
    50                  55                  60                  


Thr Ala Leu Ala Ser Ser Leu Thr Asp Leu Leu Ile Ala Glu Ser Ala 
65                  70                  75                  80  


Glu Ser Asn Tyr Ser Asn Gln Leu Ser Glu Leu Thr Gly Ile Leu Ser 
                85                  90                  95      


Asp Cys Phe Ile Gln Thr Thr Gly Ser Asp Asn Pro Ala Phe Val Ser 
            100                 105                 110         


Arg Ile Gln Ser Leu Ile Ser Val Leu Ser Gln Asn Ala Asp Thr Asn 
        115                 120                 125             


Ile 
    


<210>  23
<211>  129
<212>  PRT
<213>  Nephila clavata

<400>  23

Pro Val Pro Ser Val Phe Ser Ser Pro Ser Leu Ala Ser Gly Phe Leu 
1               5                   10                  15      


Gly Cys Leu Thr Thr Gly Ile Gly Leu Ser Pro Ala Phe Pro Phe Gln 
            20                  25                  30          


Glu Gln Gln Asp Leu Asp Asp Leu Ala Lys Val Ile Leu Ser Ala Val 
        35                  40                  45              


Thr Ser Asn Thr Asp Thr Ser Lys Ser Ala Arg Ala Gln Ala Leu Ser 
    50                  55                  60                  


Thr Ala Leu Ala Ser Ser Leu Ala Asp Leu Leu Ile Ser Glu Ser Ser 
65                  70                  75                  80  


Gly Ser Ser Tyr Gln Thr Gln Ile Ser Ala Leu Thr Asn Ile Leu Ser 
                85                  90                  95      


Asp Cys Phe Val Thr Thr Thr Gly Ser Asn Asn Pro Ala Phe Val Ser 
            100                 105                 110         


Arg Val Gln Thr Leu Ile Gly Val Leu Ser Gln Ser Ser Ser Asn Ala 
        115                 120                 125             


Ile 
    


<210>  24
<211>  128
<212>  PRT
<213>  Latrodectus hesperus

<400>  24

Ala Ser Val Asn Ile Phe Asn Ser Pro Asn Ala Ala Thr Ser Phe Leu 
1               5                   10                  15      


Asn Cys Leu Arg Ser Asn Ile Glu Ser Ser Pro Ala Phe Pro Phe Gln 
            20                  25                  30          


Glu Gln Ala Asp Leu Asp Ser Ile Ala Glu Val Ile Leu Ser Asp Val 
        35                  40                  45              


Ser Ser Val Asn Thr Ala Ser Ser Ala Thr Ser Leu Ala Leu Ser Thr 
    50                  55                  60                  


Ala Leu Ala Ser Ser Leu Ala Glu Leu Leu Val Thr Glu Ser Ala Glu 
65                  70                  75                  80  


Glu Asp Ile Asp Asn Gln Val Val Ala Leu Ser Thr Ile Leu Ser Gln 
                85                  90                  95      


Cys Phe Val Glu Thr Thr Gly Ser Pro Asn Pro Ala Phe Val Ala Ser 
            100                 105                 110         


Val Lys Ser Leu Leu Gly Val Leu Ser Gln Ser Ala Ser Asn Tyr Glu 
        115                 120                 125             


<210>  25
<211>  130
<212>  PRT
<213>  Nephila clavipes

<400>  25

Ile Ala Asn Ser Pro Phe Ser Asn Pro Asn Thr Ala Glu Ala Phe Ala 
1               5                   10                  15      


Arg Ser Phe Val Ser Asn Ile Val Ser Ser Gly Glu Phe Gly Ala Gln 
            20                  25                  30          


Gly Ala Glu Asp Phe Asp Asp Ile Ile Gln Ser Leu Ile Gln Ala Gln 
        35                  40                  45              


Ser Met Gly Lys Gly Arg His Asp Thr Lys Ala Lys Ala Lys Ala Met 
    50                  55                  60                  


Gln Val Ala Leu Ala Ser Ser Ile Ala Glu Leu Val Ile Ala Glu Ser 
65                  70                  75                  80  


Ser Gly Gly Asp Val Gln Arg Lys Thr Asn Val Ile Ser Asn Ala Leu 
                85                  90                  95      


Arg Asn Ala Leu Met Ser Thr Thr Gly Ser Pro Asn Glu Glu Phe Val 
            100                 105                 110         


His Glu Val Gln Asp Leu Ile Gln Met Leu Ser Gln Glu Gln Ile Asn 
        115                 120                 125             


Glu Val 
    130 


<210>  26
<211>  130
<212>  PRT
<213>  Nephila inaurata madagascariensis

<400>  26

Ile Val Asn Ser Pro Phe Ser Asn Pro Asn Thr Ala Glu Ala Phe Ala 
1               5                   10                  15      


Arg Ser Phe Val Ser Asn Val Val Ser Ser Gly Glu Phe Gly Ala Gln 
            20                  25                  30          


Gly Ala Glu Asp Phe Asp Asp Ile Ile Gln Ser Leu Ile Gln Ala Gln 
        35                  40                  45              


Ser Met Gly Lys Gly Arg His Asp Thr Lys Ala Lys Ala Lys Ala Met 
    50                  55                  60                  


Gln Val Ala Leu Ala Ser Ser Ile Ala Glu Leu Val Ile Ala Glu Ser 
65                  70                  75                  80  


Ser Gly Gly Asp Val Gln Arg Lys Thr Asn Val Ile Ser Asn Ala Leu 
                85                  90                  95      


Arg Asn Ala Leu Met Ser Thr Thr Gly Ser Pro Asn Glu Glu Phe Val 
            100                 105                 110         


His Glu Val Gln Asp Leu Ile Gln Met Leu Ser Gln Glu Gln Ile Asn 
        115                 120                 125             


Glu Val 
    130 


<210>  27
<211>  80
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Designed polypeptide

<400>  27

Met Gly Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Gly Met Gln Ile 
1               5                   10                  15      


Ser Met Asp Tyr Glu Ile Lys Phe His Gly Asp Gly Asp Asn Phe Asp 
            20                  25                  30          


Leu Asn Leu Asp Asp Ser Gly Gly Asp Leu Gln Leu Gln Ile Arg Gly 
        35                  40                  45              


Pro Gly Gly Arg Val His Val His Ile His Ser Ser Ser Gly Lys Val 
    50                  55                  60                  


Asp Phe His Val Asn Asn Asp Gly Gly Asp Val Glu Val Lys Met His 
65                  70                  75                  80  


<210>  28
<211>  79
<212>  PRT
<213>  Homo sapiens


<220>
<221>  DISULFID
<222>  (8)..(77)

<220>
<221>  DISULFID
<222>  (11)..(71)

<220>
<221>  DISULFID
<222>  (35)..(46)

<220>
<221>  DISULFID
<222>  (48)..(48)
<223>  Intermolecular Cys48-Cys48 linkage

<400>  28

Phe Pro Ile Pro Leu Pro Tyr Cys Trp Leu Cys Arg Ala Leu Ile Lys 
1               5                   10                  15      


Arg Ile Gln Ala Met Ile Pro Lys Gly Ala Leu Ala Val Ala Val Ala 
            20                  25                  30          


Gln Val Cys Arg Val Val Pro Leu Val Ala Gly Gly Ile Cys Gln Cys 
        35                  40                  45              


Leu Ala Glu Arg Tyr Ser Val Ile Leu Leu Asp Thr Leu Leu Gly Arg 
    50                  55                  60                  


Met Leu Pro Gln Leu Val Cys Arg Leu Val Leu Arg Cys Ser Met 
65                  70                  75                  


<210>  29
<211>  79
<212>  PRT
<213>  Mus musculus


<220>
<221>  DISULFID
<222>  (8)..(77)

<220>
<221>  DISULFID
<222>  (11)..(71)

<220>
<221>  DISULFID
<222>  (35)..(46)

<220>
<221>  DISULFID
<222>  (48)..(48)
<223>  Intermolecular Cys48-Cys48 linkage

<400>  29

Leu Pro Ile Pro Leu Pro Phe Cys Trp Leu Cys Arg Thr Leu Ile Lys 
1               5                   10                  15      


Arg Val Gln Ala Val Ile Pro Lys Gly Val Leu Ala Val Ala Val Ser 
            20                  25                  30          


Gln Val Cys His Val Val Pro Leu Val Val Gly Gly Ile Cys Gln Cys 
        35                  40                  45              


Leu Ala Glu Arg Tyr Thr Val Leu Leu Leu Asp Ala Leu Leu Gly Arg 
    50                  55                  60                  


Val Val Pro Gln Leu Val Cys Gly Leu Val Leu Arg Cys Ser Thr 
65                  70                  75                  


<210>  30
<211>  79
<212>  PRT
<213>  Sus scrofa


<220>
<221>  DISULFID
<222>  (8)..(77)

<220>
<221>  DISULFID
<222>  (11)..(71)

<220>
<221>  DISULFID
<222>  (35)..(46)

<220>
<221>  DISULFID
<222>  (48)..(48)
<223>  Intermolecular Cys48-Cys48 linkage

<400>  30

Phe Pro Ile Pro Leu Pro Phe Cys Trp Leu Cys Arg Thr Leu Ile Lys 
1               5                   10                  15      


Arg Ile Gln Ala Val Val Pro Lys Gly Val Leu Leu Lys Ala Val Ala 
            20                  25                  30          


Gln Val Cys His Val Val Pro Leu Pro Val Gly Gly Ile Cys Gln Cys 
        35                  40                  45              


Leu Ala Glu Arg Tyr Ile Val Ile Cys Leu Asn Met Leu Leu Asp Arg 
    50                  55                  60                  


Thr Leu Pro Gln Leu Val Cys Gly Leu Val Leu Arg Cys Ser Ser 
65                  70                  75                  


<210>  31
<211>  79
<212>  PRT
<213>  Oryctolagus cuniculus


<220>
<221>  DISULFID
<222>  (8)..(77)

<220>
<221>  DISULFID
<222>  (11)..(71)

<220>
<221>  DISULFID
<222>  (35)..(46)

<220>
<221>  DISULFID
<222>  (48)..(48)
<223>  Intermolecular Cys48-Cys48 linkage

<400>  31

Phe Pro Ile Pro Leu Pro Leu Cys Trp Leu Cys Arg Thr Leu Leu Lys 
1               5                   10                  15      


Arg Ile Gln Ala Met Ile Pro Lys Gly Val Leu Ala Met Ala Val Ala 
            20                  25                  30          


Gln Val Cys His Val Val Pro Leu Val Val Gly Gly Ile Cys Gln Cys 
        35                  40                  45              


Leu Ala Glu Arg Tyr Thr Val Ile Leu Leu Glu Val Leu Leu Gly His 
    50                  55                  60                  


Val Leu Pro Gln Leu Val Cys Gly Leu Val Leu Arg Cys Ser Ser 
65                  70                  75                  


<210>  32
<211>  79
<212>  PRT
<213>  Rattus norvegicus


<220>
<221>  DISULFID
<222>  (8)..(77)

<220>
<221>  DISULFID
<222>  (11)..(71)

<220>
<221>  DISULFID
<222>  (35)..(46)

<220>
<221>  DISULFID
<222>  (48)..(48)
<223>  Intermolecular Cys48-Cys48 linkage

<400>  32

Leu Pro Ile Pro Leu Pro Phe Cys Trp Leu Cys Arg Thr Leu Ile Lys 
1               5                   10                  15      


Arg Val Gln Ala Val Ile Pro Lys Gly Val Leu Ala Val Ala Val Ser 
            20                  25                  30          


Gln Val Cys His Val Val Pro Leu Val Val Gly Gly Ile Cys Gln Cys 
        35                  40                  45              


Leu Ala Glu Arg Tyr Thr Val Leu Leu Leu Asp Ala Leu Leu Gly Arg 
    50                  55                  60                  


Val Val Pro Gln Leu Val Cys Gly Leu Val Leu Arg Cys Ser Thr 
65                  70                  75                  


<210>  33
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Construct derived from SP-B


<220>
<221>  DISULFID
<222>  (1)..(33)

<220>
<221>  DISULFID
<222>  (4)..(27)

<400>  33

Cys Trp Leu Cys Arg Ala Leu Ile Lys Arg Ile Gln Ala Met Ile Pro 
1               5                   10                  15      


Lys Gly Gly Arg Met Leu Pro Gln Leu Val Cys Arg Leu Val Leu Arg 
            20                  25                  30          


Cys Ser 
        


<210>  34
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Construct derived from SP-B


<220>
<221>  DISULFID
<222>  (1)..(33)

<220>
<221>  DISULFID
<222>  (4)..(27)

<400>  34

Cys Trp Leu Cys Arg Ala Leu Ile Lys Arg Ile Gln Ala Leu Ile Pro 
1               5                   10                  15      


Lys Gly Gly Arg Leu Leu Pro Gln Leu Val Cys Arg Leu Val Leu Arg 
            20                  25                  30          


Cys Ser 
        


<210>  35
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Construct derived from SP-B


<220>
<221>  DISULFID
<222>  (1)..(27)

<220>
<221>  DISULFID
<222>  (4)..(21)

<400>  35

Cys Leu Leu Cys Arg Ala Leu Ile Lys Arg Phe Asn Arg Tyr Leu Thr 
1               5                   10                  15      


Pro Gln Leu Val Cys Arg Leu Val Leu Arg Cys 
            20                  25          


<210>  36
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Construct derived from SP-B


<220>
<221>  DISULFID
<222>  (1)..(33)

<400>  36

Cys Trp Leu Ala Arg Ala Leu Ile Lys Arg Ile Gln Ala Leu Ile Pro 
1               5                   10                  15      


Lys Gly Gly Arg Leu Leu Pro Gln Leu Val Ala Arg Leu Val Leu Arg 
            20                  25                  30          


Cys Ser 
        


<210>  37
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Construct derived from SP-B


<220>
<221>  DISULFID
<222>  (4)..(27)

<400>  37

Ala Trp Leu Cys Arg Ala Leu Ile Lys Arg Ile Gln Ala Leu Ile Pro 
1               5                   10                  15      


Lys Gly Gly Arg Leu Leu Pro Gln Leu Val Cys Arg Leu Val Leu Arg 
            20                  25                  30          


Ala Ser 
        


<210>  38
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Construct derived from SP-B


<220>
<221>  DISULFID
<222>  (1)..(33)

<400>  38

Cys Trp Leu Leu Arg Ala Leu Ile Lys Arg Ile Gln Ala Leu Ile Pro 
1               5                   10                  15      


Lys Gly Gly Arg Leu Leu Pro Gln Leu Val Leu Arg Leu Val Leu Arg 
            20                  25                  30          


Cys Ser 
        


<210>  39
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Construct derived from SP-B


<220>
<221>  DISULFID
<222>  (4)..(27)

<400>  39

Leu Trp Leu Cys Arg Ala Leu Ile Lys Arg Ile Gln Ala Leu Ile Pro 
1               5                   10                  15      


Lys Gly Gly Arg Leu Leu Pro Gln Leu Val Cys Arg Leu Val Leu Arg 
            20                  25                  30          


Leu Ser 
        


<210>  40
<211>  35
<212>  PRT
<213>  Homo sapiens

<400>  40

Phe Gly Ile Pro Cys Cys Pro Val His Leu Lys Arg Leu Leu Ile Val 
1               5                   10                  15      


Val Val Val Val Val Leu Ile Val Val Val Ile Val Gly Ala Leu Leu 
            20                  25                  30          


Met Gly Leu 
        35  


<210>  41
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Construct derived from SP-C

<400>  41

Phe Gly Ile Pro Ser Ser Pro Val His Leu Lys Arg Leu Lys Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Ile Leu Leu Leu Ile Leu Gly Ala Leu Leu 
            20                  25                  30          


Met Gly Leu 
        35  


<210>  42
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Construct derived from SP-C

<400>  42

Ile Pro Ser Ser Pro Val His Leu Lys Arg Leu Lys Leu Leu Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Ile Leu Leu Leu Ile Leu Gly Ala Leu Leu Met Gly 
            20                  25                  30          


Leu 
    


<210>  43
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Construct derived from SP-C

<400>  43

Ile Pro Ser Ser Pro Val His Leu Lys Arg Leu Lys Leu Leu Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Ile Leu Leu Leu Ile Leu Gly Ala Leu Leu 
            20                  25                  30  


<210>  44
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Construct derived from SP-C

<400>  44

Ile Pro Ser Ser Pro Val His Leu Lys Arg Leu Lys Leu Leu Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Ile Leu Leu Leu Ile Leu Gly Ala Leu Leu Leu Gly 
            20                  25                  30          


Leu 
    


<210>  45
<211>  37
<212>  PRT
<213>  Homo sapiens

<400>  45

Leu Leu Gly Asp Phe Phe Arg Lys Ser Lys Glu Lys Ile Gly Lys Glu 
1               5                   10                  15      


Phe Lys Arg Ile Val Gln Arg Ile Lys Asp Phe Leu Arg Asn Leu Val 
            20                  25                  30          


Pro Arg Thr Glu Ser 
        35          


<210>  46
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Construct derived from SP-B

<400>  46

Lys Leu Leu Leu Leu Lys Leu Leu Leu Leu Lys Leu Leu Leu Leu Lys 
1               5                   10                  15      


Leu Leu Leu Leu Lys 
            20      


<210>  47
<211>  148
<212>  PRT
<213>  Homo sapiens

<400>  47

Ala His Leu Asp Glu Glu Leu Gln Ala Thr Leu His Asp Phe Arg His 
1               5                   10                  15      


Gln Ile Leu Gln Thr Arg Gly Ala Leu Ser Leu Gln Gly Ser Ile Met 
            20                  25                  30          


Thr Val Gly Glu Lys Val Phe Ser Ser Asn Gly Gln Ser Ile Thr Phe 
        35                  40                  45              


Asp Ala Ile Gln Glu Ala Cys Ala Arg Ala Gly Gly Arg Ile Ala Val 
    50                  55                  60                  


Pro Arg Asn Pro Glu Glu Asn Glu Ala Ile Ala Ser Phe Val Lys Lys 
65                  70                  75                  80  


Tyr Asn Thr Tyr Ala Tyr Val Gly Leu Thr Glu Gly Pro Ser Pro Gly 
                85                  90                  95      


Asp Phe Arg Tyr Ser Asp Gly Thr Pro Val Asn Tyr Thr Asn Trp Tyr 
            100                 105                 110         


Arg Gly Glu Pro Ala Gly Arg Gly Lys Glu Gln Cys Val Glu Met Tyr 
        115                 120                 125             


Thr Asp Gly Gln Trp Asn Asp Arg Asn Cys Leu Tyr Ser Arg Leu Thr 
    130                 135                 140                 


Ile Cys Glu Phe 
145             


<210>  48
<211>  148
<212>  PRT
<213>  Homo sapiens

<400>  48

Ala His Leu Asp Glu Glu Leu Gln Ala Thr Leu His Asp Phe Arg His 
1               5                   10                  15      


Gln Ile Leu Gln Thr Arg Gly Ala Leu Ser Leu Gln Gly Ser Ile Met 
            20                  25                  30          


Thr Val Gly Glu Lys Val Phe Ser Ser Asn Gly Gln Ser Ile Thr Phe 
        35                  40                  45              


Asp Ala Ile Gln Glu Ala Cys Ala Arg Ala Gly Gly Arg Ile Ala Val 
    50                  55                  60                  


Pro Arg Asn Pro Glu Glu Asn Glu Ala Ile Ala Ser Phe Val Lys Lys 
65                  70                  75                  80  


Tyr Asn Thr Tyr Ala Tyr Val Gly Leu Thr Glu Gly Pro Ser Pro Gly 
                85                  90                  95      


Asp Phe Arg Tyr Ser Asp Gly Thr Pro Val Asn Tyr Thr Asn Trp Tyr 
            100                 105                 110         


Arg Gly Glu Pro Ala Gly Arg Gly Lys Glu Gln Cys Val Glu Met Tyr 
        115                 120                 125             


Thr Asp Gly Gln Trp Asn Asp Arg Asn Cys Leu Tyr Ser Arg Leu Thr 
    130                 135                 140                 


Ile Cys Glu Phe 
145             


<210>  49
<211>  152
<212>  PRT
<213>  Homo sapiens

<400>  49

Val Ala Ser Leu Arg Gln Gln Val Glu Ala Leu Gln Gly Gln Val Gln 
1               5                   10                  15      


His Leu Gln Ala Ala Phe Ser Gln Tyr Lys Lys Val Glu Leu Phe Pro 
            20                  25                  30          


Asn Gly Gln Ser Val Gly Glu Lys Ile Phe Lys Thr Ala Gly Phe Val 
        35                  40                  45              


Lys Pro Phe Thr Glu Ala Gln Leu Leu Cys Thr Gln Ala Gly Gly Gln 
    50                  55                  60                  


Leu Ala Ser Pro Arg Ser Ala Ala Glu Asn Ala Ala Leu Gln Gln Leu 
65                  70                  75                  80  


Val Val Ala Lys Asn Glu Ala Ala Phe Leu Ser Met Thr Asp Ser Lys 
                85                  90                  95      


Thr Glu Gly Lys Phe Thr Tyr Pro Thr Gly Glu Ser Leu Val Tyr Ser 
            100                 105                 110         


Asn Trp Ala Pro Gly Glu Pro Asn Asp Asp Gly Gly Ser Glu Asp Cys 
        115                 120                 125             


Val Glu Ile Phe Thr Asn Gly Lys Trp Asn Asp Arg Ala Cys Gly Glu 
    130                 135                 140                 


Lys Arg Leu Val Val Cys Glu Phe 
145                 150         


<210>  50
<211>  119
<212>  PRT
<213>  Homo sapiens

<400>  50

Gln Thr Ile Glu Glu Asn Ile Lys Ile Phe Glu Glu Glu Glu Val Glu 
1               5                   10                  15      


Phe Ile Ser Val Pro Val Pro Glu Phe Ala Asp Ser Asp Pro Ala Asn 
            20                  25                  30          


Ile Val His Asp Phe Asn Lys Lys Leu Thr Ala Tyr Leu Asp Leu Asn 
        35                  40                  45              


Leu Asp Lys Cys Tyr Val Ile Pro Leu Asn Thr Ser Ile Val Met Pro 
    50                  55                  60                  


Pro Arg Asn Leu Leu Glu Leu Leu Ile Asn Ile Lys Ala Gly Thr Tyr 
65                  70                  75                  80  


Leu Pro Gln Ser Tyr Leu Ile His Glu His Met Val Ile Thr Asp Arg 
                85                  90                  95      


Ile Glu Asn Ile Asp His Leu Gly Phe Phe Ile Tyr Arg Leu Cys His 
            100                 105                 110         


Asp Lys Glu Thr Tyr Lys Leu 
        115                 


<210>  51
<211>  398
<212>  PRT
<213>  Homo sapiens

<400>  51

Gly Pro Asn Ser Thr Gly Ala Thr Ser Pro Glu Glu Ala Ile Ala Asp 
1               5                   10                  15      


Leu Ser Val Asn Met Tyr Asn Arg Leu Arg Ala Thr Gly Glu Asp Glu 
            20                  25                  30          


Asn Ile Leu Phe Ser Pro Leu Ser Ile Ala Leu Ala Met Gly Met Met 
        35                  40                  45              


Glu Leu Gly Ala Gln Gly Ser Thr Gln Lys Glu Ile Arg His Ser Met 
    50                  55                  60                  


Gly Tyr Asp Ser Leu Lys Asn Gly Glu Glu Phe Ser Phe Leu Lys Glu 
65                  70                  75                  80  


Phe Ser Asn Met Val Thr Ala Lys Glu Ser Gln Tyr Val Met Lys Ile 
                85                  90                  95      


Ala Asn Ser Leu Phe Val Gln Asn Gly Phe His Val Asn Glu Glu Phe 
            100                 105                 110         


Leu Gln Met Met Lys Lys Tyr Phe Asn Ala Ala Val Asn His Val Asp 
        115                 120                 125             


Phe Ser Gln Asn Val Ala Val Ala Asn Tyr Ile Asn Lys Trp Val Glu 
    130                 135                 140                 


Asn Asn Thr Asn Asn Leu Val Lys Asp Leu Val Ser Pro Arg Asp Phe 
145                 150                 155                 160 


Asp Ala Ala Thr Tyr Leu Ala Leu Ile Asn Ala Val Tyr Phe Lys Gly 
                165                 170                 175     


Asn Trp Lys Ser Gln Phe Arg Pro Glu Asn Thr Arg Thr Phe Ser Phe 
            180                 185                 190         


Thr Lys Asp Asp Glu Ser Glu Val Gln Ile Pro Met Met Tyr Gln Gln 
        195                 200                 205             


Gly Glu Phe Tyr Tyr Gly Glu Phe Ser Asp Gly Ser Asn Glu Ala Gly 
    210                 215                 220                 


Gly Ile Tyr Gln Val Leu Glu Ile Pro Tyr Glu Gly Asp Glu Ile Ser 
225                 230                 235                 240 


Met Met Leu Val Leu Ser Arg Gln Glu Val Pro Leu Ala Thr Leu Glu 
                245                 250                 255     


Pro Leu Val Lys Ala Gln Leu Val Glu Glu Trp Ala Asn Ser Val Lys 
            260                 265                 270         


Lys Gln Lys Val Glu Val Tyr Leu Pro Arg Phe Thr Val Glu Gln Glu 
        275                 280                 285             


Ile Asp Leu Lys Asp Val Leu Lys Ala Leu Gly Ile Thr Glu Ile Phe 
    290                 295                 300                 


Ile Lys Asp Ala Asn Leu Thr Gly Leu Ser Asp Asn Lys Glu Ile Phe 
305                 310                 315                 320 


Leu Ser Lys Ala Ile His Lys Ser Phe Leu Glu Val Asn Glu Glu Gly 
                325                 330                 335     


Ser Glu Ala Ala Ala Val Ser Gly Met Ile Ala Ile Ser Arg Met Ala 
            340                 345                 350         


Val Leu Tyr Pro Gln Val Ile Val Asp His Pro Phe Phe Phe Leu Ile 
        355                 360                 365             


Arg Asn Arg Arg Thr Gly Thr Ile Leu Phe Met Gly Arg Val Met His 
    370                 375                 380                 


Pro Glu Thr Met Asn Thr Ser Gly His Asp Phe Glu Glu Leu 
385                 390                 395             


<210>  52
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Construct derived from SP-B

<400>  52

Ala Trp Leu Ala Arg Ala Leu Ile Lys Arg Ile Gln Ala Leu Ile Pro 
1               5                   10                  15      


Lys Gly Gly Arg Leu Leu Pro Gln Leu Val Ala Arg Leu Val Leu Arg 
            20                  25                  30          


Ala Ser 
        


<210>  53
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Construct derived from SP-B

<400>  53

Leu Trp Leu Leu Arg Ala Leu Ile Lys Arg Ile Gln Ala Leu Ile Pro 
1               5                   10                  15      


Lys Gly Gly Arg Leu Leu Pro Gln Leu Val Leu Arg Leu Val Leu Arg 
            20                  25                  30          


Leu Ser 
        


<210>  54
<211>  243
<212>  PRT
<213>  Aequorea victoria

<400>  54

Gly Pro Asn Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile 
1               5                   10                  15      


Leu Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser 
            20                  25                  30          


Gly Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe 
        35                  40                  45              


Ile Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr 
    50                  55                  60                  


Thr Leu Thr Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met 
65                  70                  75                  80  


Lys Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln 
                85                  90                  95      


Glu Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala 
            100                 105                 110         


Glu Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys 
        115                 120                 125             


Gly Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu 
    130                 135                 140                 


Tyr Asn Tyr Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys Gln Lys 
145                 150                 155                 160 


Asn Gly Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly 
                165                 170                 175     


Ser Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp 
            180                 185                 190         


Gly Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala 
        195                 200                 205             


Leu Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu 
    210                 215                 220                 


Phe Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys 
225                 230                 235                 240 


Leu Ile Asn 
            


<210>  55
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified GFP

<400>  55

Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu 
1               5                   10                  15      


Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly Glu Gly Glu 
            20                  25                  30          


Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr 
        35                  40                  45              


Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Leu Thr Tyr 
    50                  55                  60                  


Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys Gln His Asp 
65                  70                  75                  80  


Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile 
                85                  90                  95      


Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe 
            100                 105                 110         


Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe 
        115                 120                 125             


Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn Tyr Asn 
    130                 135                 140                 


Ser His Asn Val Tyr Ile Met Ala Asp Lys Gln Lys Asn Gly Ile Lys 
145                 150                 155                 160 


Val Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser Val Gln Leu 
                165                 170                 175     


Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu 
            180                 185                 190         


Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu Ser Lys Asp 
        195                 200                 205             


Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe Val Thr Ala 
    210                 215                 220                 


Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys Leu Ile Asn 
225                 230                 235                 


<210>  56
<211>  179
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein

<400>  56

Met Gly His His His His His His Met Ser His Thr Thr Pro Trp Thr 
1               5                   10                  15      


Asn Pro Gly Leu Ala Glu Asn Phe Met Asn Ser Phe Met Gln Gly Leu 
            20                  25                  30          


Ser Ser Met Pro Gly Phe Thr Ala Ser Gln Leu Asp Lys Met Ser Thr 
        35                  40                  45              


Ile Ala Gln Ser Met Val Gln Ser Ile Gln Ser Leu Ala Ala Gln Gly 
    50                  55                  60                  


Arg Thr Ser Pro Asn Asp Leu Gln Ala Leu Asn Met Ala Phe Ala Ser 
65                  70                  75                  80  


Ser Met Ala Glu Ile Ala Ala Ser Glu Glu Gly Gly Gly Ser Leu Ser 
                85                  90                  95      


Thr Lys Thr Ser Ser Ile Ala Ser Ala Met Ser Asn Ala Phe Leu Gln 
            100                 105                 110         


Thr Thr Gly Val Val Asn Gln Pro Phe Ile Asn Glu Ile Thr Gln Leu 
        115                 120                 125             


Val Ser Met Phe Ala Gln Ala Gly Met Asn Asp Val Ser Ala Gly Asn 
    130                 135                 140                 


Ser Met Ile Pro Ser Ser Pro Val His Leu Lys Arg Leu Lys Leu Leu 
145                 150                 155                 160 


Leu Leu Leu Leu Leu Leu Ile Leu Leu Leu Ile Leu Gly Ala Leu Leu 
                165                 170                 175     


Leu Gly Leu 
            


<210>  57
<211>  179
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein

<400>  57

Met Gly His His His His His His Met Ser His Thr Thr Pro Trp Thr 
1               5                   10                  15      


Asn Pro Gly Leu Ala Glu Asn Phe Met Asn Ser Phe Met Gln Gly Leu 
            20                  25                  30          


Ser Ser Met Pro Gly Phe Thr Ala Ser Gln Leu Asp Asp Met Ser Thr 
        35                  40                  45              


Ile Ala Gln Ser Met Val Gln Ser Ile Gln Ser Leu Ala Ala Gln Gly 
    50                  55                  60                  


Arg Thr Ser Pro Asn Lys Leu Gln Ala Leu Asn Met Ala Phe Ala Ser 
65                  70                  75                  80  


Ser Met Ala Glu Ile Ala Ala Ser Glu Glu Gly Gly Gly Ser Leu Ser 
                85                  90                  95      


Thr Lys Thr Ser Ser Ile Ala Ser Ala Met Ser Asn Ala Phe Leu Gln 
            100                 105                 110         


Thr Thr Gly Val Val Asn Gln Pro Phe Ile Asn Glu Ile Thr Gln Leu 
        115                 120                 125             


Val Ser Met Phe Ala Gln Ala Gly Met Asn Asp Val Ser Ala Gly Asn 
    130                 135                 140                 


Ser Met Ile Pro Ser Ser Pro Val His Leu Lys Arg Leu Lys Leu Leu 
145                 150                 155                 160 


Leu Leu Leu Leu Leu Leu Ile Leu Leu Leu Ile Leu Gly Ala Leu Leu 
                165                 170                 175     


Leu Gly Leu 
            


<210>  58
<211>  537
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Fusion protein

<400>  58
atgggccatc atcatcatca tcatatgtca cacactacac catggacaaa cccaggactc       60

gcagaaaact tcatgaacag tttcatgcaa ggcctgagct cgatgccagg tttcacggca      120

agccaattgg ataagatgtc aaccatcgca caatccatgg tacagtcaat acaatccttg      180

gcggcacaag gcaggacatc accgaatgac ctgcaggccc ttaacatggc ttttgcatct      240

tcgatggcag aaatcgcggc atccgaagaa ggagggggaa gcctttccac caaaactagc      300

tctatagcca gtgcaatgtc caacgcgttt ctgcaaacaa ctggagtggt aaaccaaccg      360

ttcataaatg aaataactca gctcgttagc atgtttgctc aagcaggtat gaatgatgtc      420

agtgctggga attctatgat tccgagcagc ccggtgcatc tgaaacgcct gaaactgctg      480

ctgctgctgc tgctgctgat tctgctgctg attctgggcg cgctgctgct gggcctg         537


<210>  59
<211>  537
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Fusion protein

<400>  59
atgggccatc atcatcatca tcatatgtca cacactacac catggacaaa cccaggactc       60

gcagaaaact tcatgaacag tttcatgcaa ggcctgagct cgatgccagg tttcacggca      120

agccaattgg atgatatgtc aaccatcgca caatccatgg tacagtcaat acaatccttg      180

gcggcacaag gcaggacatc accgaataag ctgcaggccc ttaacatggc ttttgcatct      240

tcgatggcag aaatcgcggc atccgaagaa ggagggggaa gcctttccac caaaactagc      300

tctatagcca gtgcaatgtc caacgcgttt ctgcaaacaa ctggagtggt aaaccaaccg      360

ttcataaatg aaataactca gctcgttagc atgtttgctc aagcaggtat gaatgatgtc      420

agtgctggga attctatgat tccgagcagc ccggtgcatc tgaaacgcct gaaactgctg      480

ctgctgctgc tgctgctgat tctgctgctg attctgggcg cgctgctgct gggcctg         537


<210>  60
<211>  167
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein

<400>  60

Met Gly His His His His His His Met Ser His Thr Thr Pro Trp Thr 
1               5                   10                  15      


Asn Pro Gly Leu Ala Glu Asn Phe Met Asn Ser Phe Met Gln Gly Leu 
            20                  25                  30          


Ser Ser Met Pro Gly Phe Thr Ala Ser Gln Leu Asp Lys Met Ser Thr 
        35                  40                  45              


Ile Ala Gln Ser Met Val Gln Ser Ile Gln Ser Leu Ala Ala Gln Gly 
    50                  55                  60                  


Arg Thr Ser Pro Asn Asp Leu Gln Ala Leu Asn Met Ala Phe Ala Ser 
65                  70                  75                  80  


Ser Met Ala Glu Ile Ala Ala Ser Glu Glu Gly Gly Gly Ser Leu Ser 
                85                  90                  95      


Thr Lys Thr Ser Ser Ile Ala Ser Ala Met Ser Asn Ala Phe Leu Gln 
            100                 105                 110         


Thr Thr Gly Val Val Asn Gln Pro Phe Ile Asn Glu Ile Thr Gln Leu 
        115                 120                 125             


Val Ser Met Phe Ala Gln Ala Gly Met Asn Asp Val Ser Ala Gly Asn 
    130                 135                 140                 


Ser Met Lys Leu Leu Leu Leu Lys Leu Leu Leu Leu Lys Leu Leu Leu 
145                 150                 155                 160 


Leu Lys Leu Leu Leu Leu Lys 
                165         


<210>  61
<211>  167
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein

<400>  61

Met Gly His His His His His His Met Ser His Thr Thr Pro Trp Thr 
1               5                   10                  15      


Asn Pro Gly Leu Ala Glu Asn Phe Met Asn Ser Phe Met Gln Gly Leu 
            20                  25                  30          


Ser Ser Met Pro Gly Phe Thr Ala Ser Gln Leu Asp Asp Met Ser Thr 
        35                  40                  45              


Ile Ala Gln Ser Met Val Gln Ser Ile Gln Ser Leu Ala Ala Gln Gly 
    50                  55                  60                  


Arg Thr Ser Pro Asn Lys Leu Gln Ala Leu Asn Met Ala Phe Ala Ser 
65                  70                  75                  80  


Ser Met Ala Glu Ile Ala Ala Ser Glu Glu Gly Gly Gly Ser Leu Ser 
                85                  90                  95      


Thr Lys Thr Ser Ser Ile Ala Ser Ala Met Ser Asn Ala Phe Leu Gln 
            100                 105                 110         


Thr Thr Gly Val Val Asn Gln Pro Phe Ile Asn Glu Ile Thr Gln Leu 
        115                 120                 125             


Val Ser Met Phe Ala Gln Ala Gly Met Asn Asp Val Ser Ala Gly Asn 
    130                 135                 140                 


Ser Met Lys Leu Leu Leu Leu Lys Leu Leu Leu Leu Lys Leu Leu Leu 
145                 150                 155                 160 


Leu Lys Leu Leu Leu Leu Lys 
                165         


<210>  62
<211>  501
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Fusion protein

<400>  62
atgggccatc atcatcatca tcatatgtca cacactacac catggacaaa cccaggactc       60

gcagaaaact tcatgaacag tttcatgcaa ggcctgagct cgatgccagg tttcacggca      120

agccaattgg ataagatgtc aaccatcgca caatccatgg tacagtcaat acaatccttg      180

gcggcacaag gcaggacatc accgaatgac ctgcaggccc ttaacatggc ttttgcatct      240

tcgatggcag aaatcgcggc atccgaagaa ggagggggaa gcctttccac caaaactagc      300

tctatagcca gtgcaatgtc caacgcgttt ctgcaaacaa ctggagtggt aaaccaaccg      360

ttcataaatg aaataactca gctcgttagc atgtttgctc aagcaggtat gaatgatgtc      420

agtgctggga attctatgaa actgcttctg ctgaaactcc tgttattgaa actactgctg      480

ttgaaactcc tgctgttaaa g                                                501


<210>  63
<211>  501
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Fusion protein

<400>  63
atgggccatc atcatcatca tcatatgtca cacactacac catggacaaa cccaggactc       60

gcagaaaact tcatgaacag tttcatgcaa ggcctgagct cgatgccagg tttcacggca      120

agccaattgg atgatatgtc aaccatcgca caatccatgg tacagtcaat acaatccttg      180

gcggcacaag gcaggacatc accgaataag ctgcaggccc ttaacatggc ttttgcatct      240

tcgatggcag aaatcgcggc atccgaagaa ggagggggaa gcctttccac caaaactagc      300

tctatagcca gtgcaatgtc caacgcgttt ctgcaaacaa ctggagtggt aaaccaaccg      360

ttcataaatg aaataactca gctcgttagc atgtttgctc aagcaggtat gaatgatgtc      420

agtgctggga attctatgaa actgcttctg ctgaaactcc tgttattgaa actactgctg      480

ttgaaactcc tgctgttaaa g                                                501


<210>  64
<211>  231
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein

<400>  64

Met Gly His His His His His His Met Ser His Thr Thr Pro Trp Thr 
1               5                   10                  15      


Asn Pro Gly Leu Ala Glu Asn Phe Met Asn Ser Phe Met Gln Gly Leu 
            20                  25                  30          


Ser Ser Met Pro Gly Phe Thr Ala Ser Gln Leu Asp Lys Met Ser Thr 
        35                  40                  45              


Ile Ala Gln Ser Met Val Gln Ser Ile Gln Ser Leu Ala Ala Gln Gly 
    50                  55                  60                  


Arg Thr Ser Pro Asn Asp Leu Gln Ala Leu Asn Met Ala Phe Ala Ser 
65                  70                  75                  80  


Ser Met Ala Glu Ile Ala Ala Ser Glu Glu Gly Gly Gly Ser Leu Ser 
                85                  90                  95      


Thr Lys Thr Ser Ser Ile Ala Ser Ala Met Ser Asn Ala Phe Leu Gln 
            100                 105                 110         


Thr Thr Gly Val Val Asn Gln Pro Phe Ile Asn Glu Ile Thr Gln Leu 
        115                 120                 125             


Val Ser Met Phe Ala Gln Ala Gly Met Asn Asp Val Ser Ala Gly Asn 
    130                 135                 140                 


Ser Leu Val Pro Arg Gly Ser Met Gly Glu Gln Lys Leu Ile Ser Glu 
145                 150                 155                 160 


Glu Asp Leu Gly Met Gln Ile Ser Met Asp Tyr Glu Ile Lys Phe His 
                165                 170                 175     


Gly Asp Gly Asp Asn Phe Asp Leu Asn Leu Asp Asp Ser Gly Gly Asp 
            180                 185                 190         


Leu Gln Leu Gln Ile Arg Gly Pro Gly Gly Arg Val His Val His Ile 
        195                 200                 205             


His Ser Ser Ser Gly Lys Val Asp Phe His Val Asn Asn Asp Gly Gly 
    210                 215                 220                 


Asp Val Glu Val Lys Met His 
225                 230     


<210>  65
<211>  693
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Fusion protein

<400>  65
atgggccatc atcatcatca tcatatgtca cacactacac catggacaaa cccaggactc       60

gcagaaaact tcatgaacag tttcatgcaa ggcctgagct cgatgccagg tttcacggca      120

agccaattgg ataagatgtc aaccatcgca caatccatgg tacagtcaat acaatccttg      180

gcggcacaag gcaggacatc accgaatgac ctgcaggccc ttaacatggc ttttgcatct      240

tcgatggcag aaatcgcggc atccgaagaa ggagggggaa gcctttccac caaaactagc      300

tctatagcca gtgcaatgtc caacgcgttt ctgcaaacaa ctggagtggt aaaccaaccg      360

ttcataaatg aaataactca gctcgttagc atgtttgctc aagcaggtat gaatgatgtc      420

agtgctggga attccctggt gccacgcggt tctatgggcg aacagaagtt aatctccgag      480

gaggacttgg gaatgcagat cagcatggac tatgaaatta aatttcacgg ggatggcgat      540

aatttcgacc tcaatctgga tgattcgggg ggcgatctgc agctgcaaat tcgtggtccg      600

ggcggtcgcg ttcatgtaca cattcactca agttctggca aagtggactt tcatgtcaac      660

aacgatggtg gtgatgttga agtgaaaatg cat                                   693


<210>  66
<211>  270
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein

<400>  66

Met Gly His His His His His His Met Ser His Thr Thr Pro Trp Thr 
1               5                   10                  15      


Asn Pro Gly Leu Ala Glu Asn Phe Met Asn Ser Phe Met Gln Gly Leu 
            20                  25                  30          


Ser Ser Met Pro Gly Phe Thr Ala Ser Gln Leu Asp Lys Met Ser Thr 
        35                  40                  45              


Ile Ala Gln Ser Met Val Gln Ser Ile Gln Ser Leu Ala Ala Gln Gly 
    50                  55                  60                  


Arg Thr Ser Pro Asn Asp Leu Gln Ala Leu Asn Met Ala Phe Ala Ser 
65                  70                  75                  80  


Ser Met Ala Glu Ile Ala Ala Ser Glu Glu Gly Gly Gly Ser Leu Ser 
                85                  90                  95      


Thr Lys Thr Ser Ser Ile Ala Ser Ala Met Ser Asn Ala Phe Leu Gln 
            100                 105                 110         


Thr Thr Gly Val Val Asn Gln Pro Phe Ile Asn Glu Ile Thr Gln Leu 
        115                 120                 125             


Val Ser Met Phe Ala Gln Ala Gly Met Asn Asp Val Ser Ala Gly Asn 
    130                 135                 140                 


Ser Leu Val Pro Arg Gly Ser Gln Thr Ile Glu Glu Asn Ile Lys Ile 
145                 150                 155                 160 


Phe Glu Glu Glu Glu Val Glu Phe Ile Ser Val Pro Val Pro Glu Phe 
                165                 170                 175     


Ala Asp Ser Asp Pro Ala Asn Ile Val His Asp Phe Asn Lys Lys Leu 
            180                 185                 190         


Thr Ala Tyr Leu Asp Leu Asn Leu Asp Lys Cys Tyr Val Ile Pro Leu 
        195                 200                 205             


Asn Thr Ser Ile Val Met Pro Pro Arg Asn Leu Leu Glu Leu Leu Ile 
    210                 215                 220                 


Asn Ile Lys Ala Gly Thr Tyr Leu Pro Gln Ser Tyr Leu Ile His Glu 
225                 230                 235                 240 


His Met Val Ile Thr Asp Arg Ile Glu Asn Ile Asp His Leu Gly Phe 
                245                 250                 255     


Phe Ile Tyr Arg Leu Cys His Asp Lys Glu Thr Tyr Lys Leu 
            260                 265                 270 


<210>  67
<211>  270
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein

<400>  67

Met Gly His His His His His His Met Ser His Thr Thr Pro Trp Thr 
1               5                   10                  15      


Asn Pro Gly Leu Ala Glu Asn Phe Met Asn Ser Phe Met Gln Gly Leu 
            20                  25                  30          


Ser Ser Met Pro Gly Phe Thr Ala Ser Gln Leu Asp Asp Met Ser Thr 
        35                  40                  45              


Ile Ala Gln Ser Met Val Gln Ser Ile Gln Ser Leu Ala Ala Gln Gly 
    50                  55                  60                  


Arg Thr Ser Pro Asn Lys Leu Gln Ala Leu Asn Met Ala Phe Ala Ser 
65                  70                  75                  80  


Ser Met Ala Glu Ile Ala Ala Ser Glu Glu Gly Gly Gly Ser Leu Ser 
                85                  90                  95      


Thr Lys Thr Ser Ser Ile Ala Ser Ala Met Ser Asn Ala Phe Leu Gln 
            100                 105                 110         


Thr Thr Gly Val Val Asn Gln Pro Phe Ile Asn Glu Ile Thr Gln Leu 
        115                 120                 125             


Val Ser Met Phe Ala Gln Ala Gly Met Asn Asp Val Ser Ala Gly Asn 
    130                 135                 140                 


Ser Leu Val Pro Arg Gly Ser Gln Thr Ile Glu Glu Asn Ile Lys Ile 
145                 150                 155                 160 


Phe Glu Glu Glu Glu Val Glu Phe Ile Ser Val Pro Val Pro Glu Phe 
                165                 170                 175     


Ala Asp Ser Asp Pro Ala Asn Ile Val His Asp Phe Asn Lys Lys Leu 
            180                 185                 190         


Thr Ala Tyr Leu Asp Leu Asn Leu Asp Lys Cys Tyr Val Ile Pro Leu 
        195                 200                 205             


Asn Thr Ser Ile Val Met Pro Pro Arg Asn Leu Leu Glu Leu Leu Ile 
    210                 215                 220                 


Asn Ile Lys Ala Gly Thr Tyr Leu Pro Gln Ser Tyr Leu Ile His Glu 
225                 230                 235                 240 


His Met Val Ile Thr Asp Arg Ile Glu Asn Ile Asp His Leu Gly Phe 
                245                 250                 255     


Phe Ile Tyr Arg Leu Cys His Asp Lys Glu Thr Tyr Lys Leu 
            260                 265                 270 


<210>  68
<211>  810
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Fusion protein

<400>  68
atgggccatc atcatcatca tcatatgtca cacactacac catggacaaa cccaggactc       60

gcagaaaact tcatgaacag tttcatgcaa ggcctgagct cgatgccagg tttcacggca      120

agccaattgg ataagatgtc aaccatcgca caatccatgg tacagtcaat acaatccttg      180

gcggcacaag gcaggacatc accgaatgac ctgcaggccc ttaacatggc ttttgcatct      240

tcgatggcag aaatcgcggc atccgaagaa ggagggggaa gcctttccac caaaactagc      300

tctatagcca gtgcaatgtc caacgcgttt ctgcaaacaa ctggagtggt aaaccaaccg      360

ttcataaatg aaataactca gctcgttagc atgtttgctc aagcaggtat gaatgatgtc      420

agtgctggga attccctggt gccacgcggt tctcagacaa ttgaagaaaa tattaaaatc      480

tttgaagaag aagaagttga atttatcagt gtgcctgtcc cagagtttgc agatagtgat      540

cctgccaaca ttgttcatga ctttaacaag aaacttacag cctatttaga tcttaacctg      600

gataagtgct atgtgatccc tctgaacact tccattgtta tgccacccag aaacctactg      660

gagttactta ttaacatcaa ggctggaacc tatttgcctc agtcctatct gattcatgag      720

cacatggtta ttactgatcg cattgaaaac attgatcacc tgggtttctt tatttatcga      780

ctgtgtcatg acaaggaaac ttacaaactg                                       810


<210>  69
<211>  810
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Fusion protein

<400>  69
atgggccatc atcatcatca tcatatgtca cacactacac catggacaaa cccaggactc       60

gcagaaaact tcatgaacag tttcatgcaa ggcctgagct cgatgccagg tttcacggca      120

agccaattgg atgatatgtc aaccatcgca caatccatgg tacagtcaat acaatccttg      180

gcggcacaag gcaggacatc accgaataag ctgcaggccc ttaacatggc ttttgcatct      240

tcgatggcag aaatcgcggc atccgaagaa ggagggggaa gcctttccac caaaactagc      300

tctatagcca gtgcaatgtc caacgcgttt ctgcaaacaa ctggagtggt aaaccaaccg      360

ttcataaatg aaataactca gctcgttagc atgtttgctc aagcaggtat gaatgatgtc      420

agtgctggga attccctggt gccacgcggt tctcagacaa ttgaagaaaa tattaaaatc      480

tttgaagaag aagaagttga atttatcagt gtgcctgtcc cagagtttgc agatagtgat      540

cctgccaaca ttgttcatga ctttaacaag aaacttacag cctatttaga tcttaacctg      600

gataagtgct atgtgatccc tctgaacact tccattgtta tgccacccag aaacctactg      660

gagttactta ttaacatcaa ggctggaacc tatttgcctc agtcctatct gattcatgag      720

cacatggtta ttactgatcg cattgaaaac attgatcacc tgggtttctt tatttatcga      780

ctgtgtcatg acaaggaaac ttacaaactg                                       810


<210>  70
<211>  380
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein

<400>  70

Met Gly His His His His His His Met Ser His Thr Thr Pro Trp Thr 
1               5                   10                  15      


Asn Pro Gly Leu Ala Glu Asn Phe Met Asn Ser Phe Met Gln Gly Leu 
            20                  25                  30          


Ser Ser Met Pro Gly Phe Thr Ala Ser Gln Leu Asp Lys Met Ser Thr 
        35                  40                  45              


Ile Ala Gln Ser Met Val Gln Ser Ile Gln Ser Leu Ala Ala Gln Gly 
    50                  55                  60                  


Arg Thr Ser Pro Asn Asp Leu Gln Ala Leu Asn Met Ala Phe Ala Ser 
65                  70                  75                  80  


Ser Met Ala Glu Ile Ala Ala Ser Glu Glu Gly Gly Gly Ser Leu Ser 
                85                  90                  95      


Thr Lys Thr Ser Ser Ile Ala Ser Ala Met Ser Asn Ala Phe Leu Gln 
            100                 105                 110         


Thr Thr Gly Val Val Asn Gln Pro Phe Ile Asn Glu Ile Thr Gln Leu 
        115                 120                 125             


Val Ser Met Phe Ala Gln Ala Gly Met Asn Asp Val Ser Ala Gly Asn 
    130                 135                 140                 


Ser Leu Glu Ala Leu Phe Gln Gly Glu Val Lys Asp Val Cys Val Gly 
145                 150                 155                 160 


Ser Pro Gly Ile Pro Gly Thr Pro Gly Ser His Gly Leu Pro Gly Arg 
                165                 170                 175     


Asp Gly Arg Asp Gly Leu Lys Gly Asp Pro Gly Pro Pro Gly Pro Met 
            180                 185                 190         


Gly Pro Pro Gly Glu Met Pro Cys Pro Pro Gly Asn Asp Gly Leu Pro 
        195                 200                 205             


Gly Ala Pro Gly Ile Pro Gly Glu Cys Gly Glu Lys Gly Glu Pro Gly 
    210                 215                 220                 


Glu Arg Gly Pro Pro Gly Leu Pro Ala His Leu Asp Glu Glu Leu Gln 
225                 230                 235                 240 


Ala Thr Leu His Asp Phe Arg His Gln Ile Leu Gln Thr Arg Gly Ala 
                245                 250                 255     


Leu Ser Leu Gln Gly Ser Ile Met Thr Val Gly Glu Lys Val Phe Ser 
            260                 265                 270         


Ser Asn Gly Gln Ser Ile Thr Phe Asp Ala Ile Gln Glu Ala Cys Ala 
        275                 280                 285             


Arg Ala Gly Gly Arg Ile Ala Val Pro Arg Asn Pro Glu Glu Asn Glu 
    290                 295                 300                 


Ala Ile Ala Ser Phe Val Lys Lys Tyr Asn Thr Tyr Ala Tyr Val Gly 
305                 310                 315                 320 


Leu Thr Glu Gly Pro Ser Pro Gly Asp Phe Arg Tyr Ser Asp Gly Thr 
                325                 330                 335     


Pro Val Asn Tyr Thr Asn Trp Tyr Arg Gly Glu Pro Ala Gly Arg Gly 
            340                 345                 350         


Lys Glu Gln Cys Val Glu Met Tyr Thr Asp Gly Gln Trp Asn Asp Arg 
        355                 360                 365             


Asn Cys Leu Tyr Ser Arg Leu Thr Ile Cys Glu Phe 
    370                 375                 380 


<210>  71
<211>  380
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein

<400>  71

Met Gly His His His His His His Met Ser His Thr Thr Pro Trp Thr 
1               5                   10                  15      


Asn Pro Gly Leu Ala Glu Asn Phe Met Asn Ser Phe Met Gln Gly Leu 
            20                  25                  30          


Ser Ser Met Pro Gly Phe Thr Ala Ser Gln Leu Asp Lys Met Ser Thr 
        35                  40                  45              


Ile Ala Gln Ser Met Val Gln Ser Ile Gln Ser Leu Ala Ala Gln Gly 
    50                  55                  60                  


Arg Thr Ser Pro Asn Asp Leu Gln Ala Leu Asn Met Ala Phe Ala Ser 
65                  70                  75                  80  


Ser Met Ala Glu Ile Ala Ala Ser Glu Glu Gly Gly Gly Ser Leu Ser 
                85                  90                  95      


Thr Lys Thr Ser Ser Ile Ala Ser Ala Met Ser Asn Ala Phe Leu Gln 
            100                 105                 110         


Thr Thr Gly Val Val Asn Gln Pro Phe Ile Asn Glu Ile Thr Gln Leu 
        115                 120                 125             


Val Ser Met Phe Ala Gln Ala Gly Met Asn Asp Val Ser Ala Gly Asn 
    130                 135                 140                 


Ser Leu Glu Ala Leu Phe Gln Gly Glu Val Lys Asp Val Cys Val Gly 
145                 150                 155                 160 


Ser Pro Gly Ile Pro Gly Thr Pro Gly Ser His Gly Leu Pro Gly Arg 
                165                 170                 175     


Asp Gly Arg Asp Gly Val Lys Gly Asp Pro Gly Pro Pro Gly Pro Met 
            180                 185                 190         


Gly Pro Pro Gly Glu Thr Pro Cys Pro Pro Gly Asn Asn Gly Leu Pro 
        195                 200                 205             


Gly Ala Pro Gly Val Pro Gly Glu Arg Gly Glu Lys Gly Glu Pro Gly 
    210                 215                 220                 


Glu Arg Gly Pro Pro Gly Leu Pro Ala His Leu Asp Glu Glu Leu Gln 
225                 230                 235                 240 


Ala Thr Leu His Asp Phe Arg His Gln Ile Leu Gln Thr Arg Gly Ala 
                245                 250                 255     


Leu Ser Leu Gln Gly Ser Ile Met Thr Val Gly Glu Lys Val Phe Ser 
            260                 265                 270         


Ser Asn Gly Gln Ser Ile Thr Phe Asp Ala Ile Gln Glu Ala Cys Ala 
        275                 280                 285             


Arg Ala Gly Gly Arg Ile Ala Val Pro Arg Asn Pro Glu Glu Asn Glu 
    290                 295                 300                 


Ala Ile Ala Ser Phe Val Lys Lys Tyr Asn Thr Tyr Ala Tyr Val Gly 
305                 310                 315                 320 


Leu Thr Glu Gly Pro Ser Pro Gly Asp Phe Arg Tyr Ser Asp Gly Thr 
                325                 330                 335     


Pro Val Asn Tyr Thr Asn Trp Tyr Arg Gly Glu Pro Ala Gly Arg Gly 
            340                 345                 350         


Lys Glu Gln Cys Val Glu Met Tyr Thr Asp Gly Gln Trp Asn Asp Arg 
        355                 360                 365             


Asn Cys Leu Tyr Ser Arg Leu Thr Ile Cys Glu Phe 
    370                 375                 380 


<210>  72
<211>  507
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein

<400>  72

Met Gly His His His His His His Met Ser His Thr Thr Pro Trp Thr 
1               5                   10                  15      


Asn Pro Gly Leu Ala Glu Asn Phe Met Asn Ser Phe Met Gln Gly Leu 
            20                  25                  30          


Ser Ser Met Pro Gly Phe Thr Ala Ser Gln Leu Asp Lys Met Ser Thr 
        35                  40                  45              


Ile Ala Gln Ser Met Val Gln Ser Ile Gln Ser Leu Ala Ala Gln Gly 
    50                  55                  60                  


Arg Thr Ser Pro Asn Asp Leu Gln Ala Leu Asn Met Ala Phe Ala Ser 
65                  70                  75                  80  


Ser Met Ala Glu Ile Ala Ala Ser Glu Glu Gly Gly Gly Ser Leu Ser 
                85                  90                  95      


Thr Lys Thr Ser Ser Ile Ala Ser Ala Met Ser Asn Ala Phe Leu Gln 
            100                 105                 110         


Thr Thr Gly Val Val Asn Gln Pro Phe Ile Asn Glu Ile Thr Gln Leu 
        115                 120                 125             


Val Ser Met Phe Ala Gln Ala Gly Met Asn Asp Val Ser Ala Gly Asn 
    130                 135                 140                 


Ser Leu Glu Ala Leu Phe Gln Gly Ala Glu Met Lys Thr Tyr Ser His 
145                 150                 155                 160 


Arg Thr Met Pro Ser Ala Cys Thr Leu Val Met Cys Ser Ser Val Glu 
                165                 170                 175     


Ser Gly Leu Pro Gly Arg Asp Gly Arg Asp Gly Arg Glu Gly Pro Arg 
            180                 185                 190         


Gly Glu Lys Gly Asp Pro Gly Leu Pro Gly Ala Ala Gly Gln Ala Gly 
        195                 200                 205             


Met Pro Gly Gln Ala Gly Pro Val Gly Pro Lys Gly Asp Asn Gly Ser 
    210                 215                 220                 


Val Gly Glu Pro Gly Pro Lys Gly Asp Thr Gly Pro Ser Gly Pro Pro 
225                 230                 235                 240 


Gly Pro Pro Gly Val Pro Gly Pro Ala Gly Arg Glu Gly Pro Leu Gly 
                245                 250                 255     


Lys Gln Gly Asn Ile Gly Pro Gln Gly Lys Pro Gly Pro Lys Gly Glu 
            260                 265                 270         


Ala Gly Pro Lys Gly Glu Val Gly Ala Pro Gly Met Gln Gly Ser Ala 
        275                 280                 285             


Gly Ala Arg Gly Leu Ala Gly Pro Lys Gly Glu Arg Gly Val Pro Gly 
    290                 295                 300                 


Glu Arg Gly Val Pro Gly Asn Thr Gly Ala Ala Gly Ser Ala Gly Ala 
305                 310                 315                 320 


Met Gly Pro Gln Gly Ser Pro Gly Ala Arg Gly Pro Pro Gly Leu Lys 
                325                 330                 335     


Gly Asp Lys Gly Ile Pro Gly Asp Lys Gly Ala Lys Gly Glu Ser Gly 
            340                 345                 350         


Leu Pro Asp Val Ala Ser Leu Arg Gln Gln Val Glu Ala Leu Gln Gly 
        355                 360                 365             


Gln Val Gln His Leu Gln Ala Ala Phe Ser Gln Tyr Lys Lys Val Glu 
    370                 375                 380                 


Leu Phe Pro Asn Gly Gln Ser Val Gly Glu Lys Ile Phe Lys Thr Ala 
385                 390                 395                 400 


Gly Phe Val Lys Pro Phe Thr Glu Ala Gln Leu Leu Cys Thr Gln Ala 
                405                 410                 415     


Gly Gly Gln Leu Ala Ser Pro Arg Ser Ala Ala Glu Asn Ala Ala Leu 
            420                 425                 430         


Gln Gln Leu Val Val Ala Lys Asn Glu Ala Ala Phe Leu Ser Met Thr 
        435                 440                 445             


Asp Ser Lys Thr Glu Gly Lys Phe Thr Tyr Pro Thr Gly Glu Ser Leu 
    450                 455                 460                 


Val Tyr Ser Asn Trp Ala Pro Gly Glu Pro Asn Asp Asp Gly Gly Ser 
465                 470                 475                 480 


Glu Asp Cys Val Glu Ile Phe Thr Asn Gly Lys Trp Asn Asp Arg Ala 
                485                 490                 495     


Cys Gly Glu Lys Arg Leu Val Val Cys Glu Phe 
            500                 505         


<210>  73
<211>  300
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein

<400>  73

Met Gly His His His His His His Met Ser His Thr Thr Pro Trp Thr 
1               5                   10                  15      


Asn Pro Gly Leu Ala Glu Asn Phe Met Asn Ser Phe Met Gln Gly Leu 
            20                  25                  30          


Ser Ser Met Pro Gly Phe Thr Ala Ser Gln Leu Asp Lys Met Ser Thr 
        35                  40                  45              


Ile Ala Gln Ser Met Val Gln Ser Ile Gln Ser Leu Ala Ala Gln Gly 
    50                  55                  60                  


Arg Thr Ser Pro Asn Asp Leu Gln Ala Leu Asn Met Ala Phe Ala Ser 
65                  70                  75                  80  


Ser Met Ala Glu Ile Ala Ala Ser Glu Glu Gly Gly Gly Ser Leu Ser 
                85                  90                  95      


Thr Lys Thr Ser Ser Ile Ala Ser Ala Met Ser Asn Ala Phe Leu Gln 
            100                 105                 110         


Thr Thr Gly Val Val Asn Gln Pro Phe Ile Asn Glu Ile Thr Gln Leu 
        115                 120                 125             


Val Ser Met Phe Ala Gln Ala Gly Met Asn Asp Val Ser Ala Gly Asn 
    130                 135                 140                 


Ser Leu Glu Ala Leu Phe Gln Gly Ala His Leu Asp Glu Glu Leu Gln 
145                 150                 155                 160 


Ala Thr Leu His Asp Phe Arg His Gln Ile Leu Gln Thr Arg Gly Ala 
                165                 170                 175     


Leu Ser Leu Gln Gly Ser Ile Met Thr Val Gly Glu Lys Val Phe Ser 
            180                 185                 190         


Ser Asn Gly Gln Ser Ile Thr Phe Asp Ala Ile Gln Glu Ala Cys Ala 
        195                 200                 205             


Arg Ala Gly Gly Arg Ile Ala Val Pro Arg Asn Pro Glu Glu Asn Glu 
    210                 215                 220                 


Ala Ile Ala Ser Phe Val Lys Lys Tyr Asn Thr Tyr Ala Tyr Val Gly 
225                 230                 235                 240 


Leu Thr Glu Gly Pro Ser Pro Gly Asp Phe Arg Tyr Ser Asp Gly Thr 
                245                 250                 255     


Pro Val Asn Tyr Thr Asn Trp Tyr Arg Gly Glu Pro Ala Gly Arg Gly 
            260                 265                 270         


Lys Glu Gln Cys Val Glu Met Tyr Thr Asp Gly Gln Trp Asn Asp Arg 
        275                 280                 285             


Asn Cys Leu Tyr Ser Arg Leu Thr Ile Cys Glu Phe 
    290                 295                 300 


<210>  74
<211>  300
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein

<400>  74

Met Gly His His His His His His Met Ser His Thr Thr Pro Trp Thr 
1               5                   10                  15      


Asn Pro Gly Leu Ala Glu Asn Phe Met Asn Ser Phe Met Gln Gly Leu 
            20                  25                  30          


Ser Ser Met Pro Gly Phe Thr Ala Ser Gln Leu Asp Lys Met Ser Thr 
        35                  40                  45              


Ile Ala Gln Ser Met Val Gln Ser Ile Gln Ser Leu Ala Ala Gln Gly 
    50                  55                  60                  


Arg Thr Ser Pro Asn Asp Leu Gln Ala Leu Asn Met Ala Phe Ala Ser 
65                  70                  75                  80  


Ser Met Ala Glu Ile Ala Ala Ser Glu Glu Gly Gly Gly Ser Leu Ser 
                85                  90                  95      


Thr Lys Thr Ser Ser Ile Ala Ser Ala Met Ser Asn Ala Phe Leu Gln 
            100                 105                 110         


Thr Thr Gly Val Val Asn Gln Pro Phe Ile Asn Glu Ile Thr Gln Leu 
        115                 120                 125             


Val Ser Met Phe Ala Gln Ala Gly Met Asn Asp Val Ser Ala Gly Asn 
    130                 135                 140                 


Ser Leu Glu Ala Leu Phe Gln Gly Ala His Leu Asp Glu Glu Leu Gln 
145                 150                 155                 160 


Ala Thr Leu His Asp Phe Arg His Gln Ile Leu Gln Thr Arg Gly Ala 
                165                 170                 175     


Leu Ser Leu Gln Gly Ser Ile Met Thr Val Gly Glu Lys Val Phe Ser 
            180                 185                 190         


Ser Asn Gly Gln Ser Ile Thr Phe Asp Ala Ile Gln Glu Ala Cys Ala 
        195                 200                 205             


Arg Ala Gly Gly Arg Ile Ala Val Pro Arg Asn Pro Glu Glu Asn Glu 
    210                 215                 220                 


Ala Ile Ala Ser Phe Val Lys Lys Tyr Asn Thr Tyr Ala Tyr Val Gly 
225                 230                 235                 240 


Leu Thr Glu Gly Pro Ser Pro Gly Asp Phe Arg Tyr Ser Asp Gly Thr 
                245                 250                 255     


Pro Val Asn Tyr Thr Asn Trp Tyr Arg Gly Glu Pro Ala Gly Arg Gly 
            260                 265                 270         


Lys Glu Gln Cys Val Glu Met Tyr Thr Asp Gly Gln Trp Asn Asp Arg 
        275                 280                 285             


Asn Cys Leu Tyr Ser Arg Leu Thr Ile Cys Glu Phe 
    290                 295                 300 


<210>  75
<211>  304
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein

<400>  75

Met Gly His His His His His His Met Ser His Thr Thr Pro Trp Thr 
1               5                   10                  15      


Asn Pro Gly Leu Ala Glu Asn Phe Met Asn Ser Phe Met Gln Gly Leu 
            20                  25                  30          


Ser Ser Met Pro Gly Phe Thr Ala Ser Gln Leu Asp Lys Met Ser Thr 
        35                  40                  45              


Ile Ala Gln Ser Met Val Gln Ser Ile Gln Ser Leu Ala Ala Gln Gly 
    50                  55                  60                  


Arg Thr Ser Pro Asn Asp Leu Gln Ala Leu Asn Met Ala Phe Ala Ser 
65                  70                  75                  80  


Ser Met Ala Glu Ile Ala Ala Ser Glu Glu Gly Gly Gly Ser Leu Ser 
                85                  90                  95      


Thr Lys Thr Ser Ser Ile Ala Ser Ala Met Ser Asn Ala Phe Leu Gln 
            100                 105                 110         


Thr Thr Gly Val Val Asn Gln Pro Phe Ile Asn Glu Ile Thr Gln Leu 
        115                 120                 125             


Val Ser Met Phe Ala Gln Ala Gly Met Asn Asp Val Ser Ala Gly Asn 
    130                 135                 140                 


Ser Leu Glu Ala Leu Phe Gln Gly Val Ala Ser Leu Arg Gln Gln Val 
145                 150                 155                 160 


Glu Ala Leu Gln Gly Gln Val Gln His Leu Gln Ala Ala Phe Ser Gln 
                165                 170                 175     


Tyr Lys Lys Val Glu Leu Phe Pro Asn Gly Gln Ser Val Gly Glu Lys 
            180                 185                 190         


Ile Phe Lys Thr Ala Gly Phe Val Lys Pro Phe Thr Glu Ala Gln Leu 
        195                 200                 205             


Leu Cys Thr Gln Ala Gly Gly Gln Leu Ala Ser Pro Arg Ser Ala Ala 
    210                 215                 220                 


Glu Asn Ala Ala Leu Gln Gln Leu Val Val Ala Lys Asn Glu Ala Ala 
225                 230                 235                 240 


Phe Leu Ser Met Thr Asp Ser Lys Thr Glu Gly Lys Phe Thr Tyr Pro 
                245                 250                 255     


Thr Gly Glu Ser Leu Val Tyr Ser Asn Trp Ala Pro Gly Glu Pro Asn 
            260                 265                 270         


Asp Asp Gly Gly Ser Glu Asp Cys Val Glu Ile Phe Thr Asn Gly Lys 
        275                 280                 285             


Trp Asn Asp Arg Ala Cys Gly Glu Lys Arg Leu Val Val Cys Glu Phe 
    290                 295                 300                 


<210>  76
<211>  1140
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Fusion protein

<400>  76
atgggccatc atcatcatca tcatatgtca cacactacac catggacaaa cccaggactc       60

gcagaaaact tcatgaacag tttcatgcaa ggcctgagct cgatgccagg tttcacggca      120

agccaattgg ataagatgtc aaccatcgca caatccatgg tacagtcaat acaatccttg      180

gcggcacaag gcaggacatc accgaatgac ctgcaggccc ttaacatggc ttttgcatct      240

tcgatggcag aaatcgcggc atccgaagaa ggagggggaa gcctttccac caaaactagc      300

tctatagcca gtgcaatgtc caacgcgttt ctgcaaacaa ctggagtggt aaaccaaccg      360

ttcataaatg aaataactca gctcgttagc atgtttgctc aagcaggtat gaatgatgtc      420

agtgctggga attcactgga agcgctgttc cagggcgaag tgaaggacgt ttgtgttgga      480

agccctggta tccccggcac tcctggatcc cacggcctgc caggcaggga cgggagagat      540

ggtctcaaag gagaccctgg ccctccaggc cccatgggtc cgcctggaga aatgccatgt      600

cctcctggaa atgatgggct gcctggagcc cctggtatcc ctggagagtg tggagagaag      660

ggggagcctg gcgagagggg ccctccaggg cttccagctc atctagatga ggagctccaa      720

gccacactcc acgactttag acatcaaatc ctgcagacaa ggggagccct cagtctgcag      780

ggctccataa tgacggtagg agagaaggtc ttctccagca atgggcagtc catcactttt      840

gatgccattc aggaggcatg tgccagagca ggcggccgca ttgctgtccc aaggaatcca      900

gaggaaaatg aggccattgc aagcttcgtg aagaagtaca acacatatgc ctatgtaggc      960

ctgactgagg gtcccagccc tggagacttc cgctactcag acgggacccc tgtaaactac     1020

accaactggt accgagggga gcccgcaggt cggggaaaag agcagtgtgt ggagatgtac     1080

acagatgggc agtggaatga caggaactgc ctgtactccc gactgaccat ctgtgagttc     1140


<210>  77
<211>  1140
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Fusion protein

<400>  77
atgggccatc atcatcatca tcatatgtca cacactacac catggacaaa cccaggactc       60

gcagaaaact tcatgaacag tttcatgcaa ggcctgagct cgatgccagg tttcacggca      120

agccaattgg ataagatgtc aaccatcgca caatccatgg tacagtcaat acaatccttg      180

gcggcacaag gcaggacatc accgaatgac ctgcaggccc ttaacatggc ttttgcatct      240

tcgatggcag aaatcgcggc atccgaagaa ggagggggaa gcctttccac caaaactagc      300

tctatagcca gtgcaatgtc caacgcgttt ctgcaaacaa ctggagtggt aaaccaaccg      360

ttcataaatg aaataactca gctcgttagc atgtttgctc aagcaggtat gaatgatgtc      420

agtgctggga attcactgga agcgctgttc cagggcgaag tgaaggacgt ttgtgttgga      480

agccctggta tccccggcac tcctggatcc cacggcctgc caggcaggga cgggagagat      540

ggtgtcaaag gagaccctgg ccctccaggc cccatgggtc cgcctggaga aacaccatgt      600

cctcctggga ataatgggct gcctggagcc cctggtgtcc ctggagagcg tggagagaag      660

ggggagcctg gcgagagagg ccctccaggg cttccagctc atctagatga ggagctccaa      720

gccacactcc acgacttcag acatcaaatc ctgcagacaa ggggagccct cagtctgcag      780

ggctccataa tgacagtagg agagaaggtc ttctccagca atgggcagtc catcactttt      840

gatgccattc aggaggcatg tgccagagca ggcggccgca ttgctgtccc aaggaatcca      900

gaggaaaatg aggccattgc aagcttcgtg aagaagtaca acacatatgc ctatgtaggc      960

ctgactgagg gtcccagccc tggagacttc cgctactcag atgggacccc tgtaaactac     1020

accaactggt accgagggga gcctgcaggt cggggaaaag agcagtgtgt ggagatgtac     1080

acagatgggc agtggaatga caggaactgc ctgtactccc gactgaccat ctgtgagttc     1140


<210>  78
<211>  1521
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Fusion protein

<400>  78
atgggccatc atcatcatca tcatatgtca cacactacac catggacaaa cccaggactc       60

gcagaaaact tcatgaacag tttcatgcaa ggcctgagct cgatgccagg tttcacggca      120

agccaattgg ataagatgtc aaccatcgca caatccatgg tacagtcaat acaatccttg      180

gcggcacaag gcaggacatc accgaatgac ctgcaggccc ttaacatggc ttttgcatct      240

tcgatggcag aaatcgcggc atccgaagaa ggagggggaa gcctttccac caaaactagc      300

tctatagcca gtgcaatgtc caacgcgttt ctgcaaacaa ctggagtggt aaaccaaccg      360

ttcataaatg aaataactca gctcgttagc atgtttgctc aagcaggtat gaatgatgtc      420

agtgctggga attcactgga agcgctgttc cagggcgcag aaatgaagac ctactcccac      480

agaacaatgc ccagtgcttg caccctggtc atgtgtagct cagtggagag tggcctgcct      540

ggtcgcgatg gacgggatgg gagagagggc cctcggggcg agaaggggga cccaggtttg      600

ccaggagctg cagggcaagc agggatgcct ggacaagctg gcccagttgg gcccaaaggg      660

gacaatggct ctgttggaga acctggacca aagggagaca ctgggccaag tggacctcca      720

ggacctcccg gtgtgcctgg tccagctgga agagaaggtc ccctggggaa gcaggggaac      780

ataggacctc agggcaagcc aggcccaaaa ggagaagctg ggcccaaagg agaagtaggt      840

gccccaggca tgcagggctc ggcaggggca agaggcctcg caggccctaa gggagagcga      900

ggtgtccctg gtgagcgtgg agtccctgga aacacagggg cagcagggtc tgctggagcc      960

atgggtcccc agggaagtcc aggtgccagg ggacccccgg gattgaaggg ggacaaaggc     1020

attcctggag acaaaggagc aaagggagaa agtgggcttc cagatgttgc ttctctgagg     1080

cagcaggttg aggccttaca gggacaagta cagcacctcc aggctgcttt ctctcagtat     1140

aagaaagttg agctcttccc aaatggccaa agtgtcgggg agaagatttt caagacagca     1200

ggctttgtaa aaccatttac ggaggcacag ctgctgtgca cacaggctgg tggacagttg     1260

gcctctccac gctctgccgc tgagaatgcc gccttgcaac agctggtcgt agctaagaac     1320

gaggctgctt tcctgagcat gactgattcc aagacagagg gcaagttcac ctaccccaca     1380

ggagagtccc tggtctattc caactgggcc ccaggggagc ccaacgatga tggcgggtca     1440

gaggactgtg tggagatctt caccaatggc aagtggaatg acagggcttg tggagaaaag     1500

cgtcttgtgg tctgcgagtt c                                               1521


<210>  79
<211>  900
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Fusion protein

<400>  79
atgggccatc atcatcatca tcatatgtca cacactacac catggacaaa cccaggactc       60

gcagaaaact tcatgaacag tttcatgcaa ggcctgagct cgatgccagg tttcacggca      120

agccaattgg ataagatgtc aaccatcgca caatccatgg tacagtcaat acaatccttg      180

gcggcacaag gcaggacatc accgaatgac ctgcaggccc ttaacatggc ttttgcatct      240

tcgatggcag aaatcgcggc atccgaagaa ggagggggaa gcctttccac caaaactagc      300

tctatagcca gtgcaatgtc caacgcgttt ctgcaaacaa ctggagtggt aaaccaaccg      360

ttcataaatg aaataactca gctcgttagc atgtttgctc aagcaggtat gaatgatgtc      420

agtgctggga attcactgga agcgctgttc cagggcgctc atctagatga ggagctccaa      480

gccacactcc acgactttag acatcaaatc ctgcagacaa ggggagccct cagtctgcag      540

ggctccataa tgacggtagg agagaaggtc ttctccagca atgggcagtc catcactttt      600

gatgccattc aggaggcatg tgccagagca ggcggccgca ttgctgtccc aaggaatcca      660

gaggaaaatg aggccattgc aagcttcgtg aagaagtaca acacatatgc ctatgtaggc      720

ctgactgagg gtcccagccc tggagacttc cgctactcag acgggacccc tgtaaactac      780

accaactggt accgagggga gcccgcaggt cggggaaaag agcagtgtgt ggagatgtac      840

acagatgggc agtggaatga caggaactgc ctgtactccc gactgaccat ctgtgagttc      900


<210>  80
<211>  900
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Fusion protein

<400>  80
atgggccatc atcatcatca tcatatgtca cacactacac catggacaaa cccaggactc       60

gcagaaaact tcatgaacag tttcatgcaa ggcctgagct cgatgccagg tttcacggca      120

agccaattgg ataagatgtc aaccatcgca caatccatgg tacagtcaat acaatccttg      180

gcggcacaag gcaggacatc accgaatgac ctgcaggccc ttaacatggc ttttgcatct      240

tcgatggcag aaatcgcggc atccgaagaa ggagggggaa gcctttccac caaaactagc      300

tctatagcca gtgcaatgtc caacgcgttt ctgcaaacaa ctggagtggt aaaccaaccg      360

ttcataaatg aaataactca gctcgttagc atgtttgctc aagcaggtat gaatgatgtc      420

agtgctggga attcactgga agcgctgttc cagggcgctc atctagatga ggagctccaa      480

gccacactcc acgacttcag acatcaaatc ctgcagacaa ggggagccct cagtctgcag      540

ggctccataa tgacagtagg agagaaggtc ttctccagca atgggcagtc catcactttt      600

gatgccattc aggaggcatg tgccagagca ggcggccgca ttgctgtccc aaggaatcca      660

gaggaaaatg aggccattgc aagcttcgtg aagaagtaca acacatatgc ctatgtaggc      720

ctgactgagg gtcccagccc tggagacttc cgctactcag atgggacccc tgtaaactac      780

accaactggt accgagggga gcctgcaggt cggggaaaag agcagtgtgt ggagatgtac      840

acagatgggc agtggaatga caggaactgc ctgtactccc gactgaccat ctgtgagttc      900


<210>  81
<211>  912
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Fusion protein

<400>  81
atgggccatc atcatcatca tcatatgtca cacactacac catggacaaa cccaggactc       60

gcagaaaact tcatgaacag tttcatgcaa ggcctgagct cgatgccagg tttcacggca      120

agccaattgg ataagatgtc aaccatcgca caatccatgg tacagtcaat acaatccttg      180

gcggcacaag gcaggacatc accgaatgac ctgcaggccc ttaacatggc ttttgcatct      240

tcgatggcag aaatcgcggc atccgaagaa ggagggggaa gcctttccac caaaactagc      300

tctatagcca gtgcaatgtc caacgcgttt ctgcaaacaa ctggagtggt aaaccaaccg      360

ttcataaatg aaataactca gctcgttagc atgtttgctc aagcaggtat gaatgatgtc      420

agtgctggga attcactgga agcgctgttc cagggcgttg cttctctgag gcagcaggtt      480

gaggccttac agggacaagt acagcacctc caggctgctt tctctcagta taagaaagtt      540

gagctcttcc caaatggcca aagtgtcggg gagaagattt tcaagacagc aggctttgta      600

aaaccattta cggaggcaca gctgctgtgc acacaggctg gtggacagtt ggcctctcca      660

cgctctgccg ctgagaatgc cgccttgcaa cagctggtcg tagctaagaa cgaggctgct      720

ttcctgagca tgactgattc caagacagag ggcaagttca cctaccccac aggagagtcc      780

ctggtctatt ccaactgggc cccaggggag cccaacgatg atggcgggtc agaggactgt      840

gtggagatct tcaccaatgg caagtggaat gacagggctt gtggagaaaa gcgtcttgtg      900

gtctgcgagt tc                                                          912


<210>  82
<211>  193
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein

<400>  82

Met Gly His His His His His His Met Ser His Thr Thr Pro Trp Thr 
1               5                   10                  15      


Asn Pro Gly Leu Ala Glu Asn Phe Met Asn Ser Phe Met Gln Gly Leu 
            20                  25                  30          


Ser Ser Met Pro Gly Phe Thr Ala Ser Gln Leu Asp Lys Met Ser Thr 
        35                  40                  45              


Ile Ala Gln Ser Met Val Gln Ser Ile Gln Ser Leu Ala Ala Gln Gly 
    50                  55                  60                  


Arg Thr Ser Pro Asn Asp Leu Gln Ala Leu Asn Met Ala Phe Ala Ser 
65                  70                  75                  80  


Ser Met Ala Glu Ile Ala Ala Ser Glu Glu Gly Gly Gly Ser Leu Ser 
                85                  90                  95      


Thr Lys Thr Ser Ser Ile Ala Ser Ala Met Ser Asn Ala Phe Leu Gln 
            100                 105                 110         


Thr Thr Gly Val Val Asn Gln Pro Phe Ile Asn Glu Ile Thr Gln Leu 
        115                 120                 125             


Val Ser Met Phe Ala Gln Ala Gly Met Asn Asp Val Ser Ala Gly Asn 
    130                 135                 140                 


Ser Leu Val Pro Arg Gly Ser Asp Ala Glu Phe Arg His Asp Ser Gly 
145                 150                 155                 160 


Tyr Glu Val His His Gln Lys Leu Val Phe Phe Ala Glu Asp Val Gly 
                165                 170                 175     


Ser Asn Lys Gly Ala Ile Ile Gly Leu Met Val Gly Gly Val Val Ile 
            180                 185                 190         


Ala 
    


<210>  83
<211>  579
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Fusion protein

<400>  83
atgggccatc atcatcatca tcatatgtca cacactacac catggacaaa cccaggactc       60

gcagaaaact tcatgaacag tttcatgcaa ggcctgagct cgatgccagg tttcacggca      120

agccaattgg ataagatgtc aaccatcgca caatccatgg tacagtcaat acaatccttg      180

gcggcacaag gcaggacatc accgaatgac ctgcaggccc ttaacatggc ttttgcatct      240

tcgatggcag aaatcgcggc atccgaagaa ggagggggaa gcctttccac caaaactagc      300

tctatagcca gtgcaatgtc caacgcgttt ctgcaaacaa ctggagtggt aaaccaaccg      360

ttcataaatg aaataactca gctcgttagc atgtttgctc aagcaggtat gaatgatgtc      420

agtgctggga attccctggt gccacgcggt tctgacgctg aattccgtca cgactctggt      480

tacgaagttc accaccagaa gctggtgttc ttcgctgaag acgtgggttc taacaagggt      540

gctatcatcg gtctgatggt tggtggcgtt gtgatcgcg                             579


<210>  84
<211>  188
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein

<400>  84

Met Gly His His His His His His Met Ser His Thr Thr Pro Trp Thr 
1               5                   10                  15      


Asn Pro Gly Leu Ala Glu Asn Phe Met Asn Ser Phe Met Gln Gly Leu 
            20                  25                  30          


Ser Ser Met Pro Gly Phe Thr Ala Ser Gln Leu Asp Lys Met Ser Thr 
        35                  40                  45              


Ile Ala Gln Ser Met Val Gln Ser Ile Gln Ser Leu Ala Ala Gln Gly 
    50                  55                  60                  


Arg Thr Ser Pro Asn Asp Leu Gln Ala Leu Asn Met Ala Phe Ala Ser 
65                  70                  75                  80  


Ser Met Ala Glu Ile Ala Ala Ser Glu Glu Gly Gly Gly Ser Leu Ser 
                85                  90                  95      


Thr Lys Thr Ser Ser Ile Ala Ser Ala Met Ser Asn Ala Phe Leu Gln 
            100                 105                 110         


Thr Thr Gly Val Val Asn Gln Pro Phe Ile Asn Glu Ile Thr Gln Leu 
        115                 120                 125             


Val Ser Met Phe Ala Gln Ala Gly Met Asn Asp Val Ser Ala Gly Asn 
    130                 135                 140                 


Ser Leu Val Pro Arg Gly Ser Lys Cys Asn Thr Ala Thr Cys Ala Thr 
145                 150                 155                 160 


Gln Arg Leu Ala Asn Phe Leu Val His Ser Ser Asn Asn Phe Gly Ala 
                165                 170                 175     


Ile Leu Ser Ser Thr Asn Val Gly Ser Asn Thr Tyr 
            180                 185             


<210>  85
<211>  564
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Fusion protein

<400>  85
atgggccatc atcatcatca tcatatgtca cacactacac catggacaaa cccaggactc       60

gcagaaaact tcatgaacag tttcatgcaa ggcctgagct cgatgccagg tttcacggca      120

agccaattgg ataagatgtc aaccatcgca caatccatgg tacagtcaat acaatccttg      180

gcggcacaag gcaggacatc accgaatgac ctgcaggccc ttaacatggc ttttgcatct      240

tcgatggcag aaatcgcggc atccgaagaa ggagggggaa gcctttccac caaaactagc      300

tctatagcca gtgcaatgtc caacgcgttt ctgcaaacaa ctggagtggt aaaccaaccg      360

ttcataaatg aaataactca gctcgttagc atgtttgctc aagcaggtat gaatgatgtc      420

agtgctggga attccctggt gccacgcggt tctaaatgca acactgccac atgtgcaacg      480

cagcgcctgg caaatttttt agttcattcc agcaacaact ttggtgccat tctctcatct      540

accaacgtgg gatccaatac atat                                             564


<210>  86
<211>  291
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein

<400>  86

Met Gly His His His His His His Met Ser His Thr Thr Pro Trp Thr 
1               5                   10                  15      


Asn Pro Gly Leu Ala Glu Asn Phe Met Asn Ser Phe Met Gln Gly Leu 
            20                  25                  30          


Ser Ser Met Pro Gly Phe Thr Ala Ser Gln Leu Asp Asp Met Ser Thr 
        35                  40                  45              


Ile Ala Gln Ser Met Val Gln Ser Ile Gln Ser Leu Ala Ala Gln Gly 
    50                  55                  60                  


Arg Thr Ser Pro Asn Lys Leu Gln Ala Leu Asn Met Ala Phe Ala Ser 
65                  70                  75                  80  


Ser Met Ala Glu Ile Ala Ala Ser Glu Glu Gly Gly Gly Ser Leu Ser 
                85                  90                  95      


Thr Lys Thr Ser Ser Ile Ala Ser Ala Met Ser Asn Ala Phe Leu Gln 
            100                 105                 110         


Thr Thr Gly Val Val Asn Gln Pro Phe Ile Asn Glu Ile Thr Gln Leu 
        115                 120                 125             


Val Ser Met Phe Ala Gln Ala Gly Met Asn Asp Val Ser Ala Gly Asn 
    130                 135                 140                 


Ser Leu Val Pro Arg Gly Ser Gln Val Leu Ser Tyr Lys Glu Ala Val 
145                 150                 155                 160 


Leu Arg Ala Ile Asp Gly Ile Asn Gln Arg Ser Ser Asp Ala Asn Leu 
                165                 170                 175     


Tyr Arg Leu Leu Asp Leu Asp Pro Arg Pro Thr Met Asp Gly Asp Pro 
            180                 185                 190         


Asp Thr Pro Lys Pro Val Ser Phe Thr Val Lys Glu Thr Val Cys Pro 
        195                 200                 205             


Arg Thr Thr Gln Gln Ser Pro Glu Asp Cys Asp Phe Lys Lys Asp Gly 
    210                 215                 220                 


Leu Val Lys Arg Cys Met Gly Thr Val Thr Leu Asn Gln Ala Arg Gly 
225                 230                 235                 240 


Ser Phe Asp Ile Ser Cys Asp Lys Asp Asn Lys Arg Phe Ala Leu Leu 
                245                 250                 255     


Gly Asp Phe Phe Arg Lys Ser Lys Glu Lys Ile Gly Lys Glu Phe Lys 
            260                 265                 270         


Arg Ile Val Gln Arg Ile Lys Asp Phe Leu Arg Asn Leu Val Pro Arg 
        275                 280                 285             


Thr Glu Ser 
    290     


<210>  87
<211>  291
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein

<400>  87

Met Gly His His His His His His Met Ser His Thr Thr Pro Trp Thr 
1               5                   10                  15      


Asn Pro Gly Leu Ala Glu Asn Phe Met Asn Ser Phe Met Gln Gly Leu 
            20                  25                  30          


Ser Ser Met Pro Gly Phe Thr Ala Ser Gln Leu Asp Lys Met Ser Thr 
        35                  40                  45              


Ile Ala Gln Ser Met Val Gln Ser Ile Gln Ser Leu Ala Ala Gln Gly 
    50                  55                  60                  


Arg Thr Ser Pro Asn Asp Leu Gln Ala Leu Asn Met Ala Phe Ala Ser 
65                  70                  75                  80  


Ser Met Ala Glu Ile Ala Ala Ser Glu Glu Gly Gly Gly Ser Leu Ser 
                85                  90                  95      


Thr Lys Thr Ser Ser Ile Ala Ser Ala Met Ser Asn Ala Phe Leu Gln 
            100                 105                 110         


Thr Thr Gly Val Val Asn Gln Pro Phe Ile Asn Glu Ile Thr Gln Leu 
        115                 120                 125             


Val Ser Met Phe Ala Gln Ala Gly Met Asn Asp Val Ser Ala Gly Asn 
    130                 135                 140                 


Ser Leu Val Pro Arg Gly Ser Gln Val Leu Ser Tyr Lys Glu Ala Val 
145                 150                 155                 160 


Leu Arg Ala Ile Asp Gly Ile Asn Gln Arg Ser Ser Asp Ala Asn Leu 
                165                 170                 175     


Tyr Arg Leu Leu Asp Leu Asp Pro Arg Pro Thr Met Asp Gly Asp Pro 
            180                 185                 190         


Asp Thr Pro Lys Pro Val Ser Phe Thr Val Lys Glu Thr Val Cys Pro 
        195                 200                 205             


Arg Thr Thr Gln Gln Ser Pro Glu Asp Cys Asp Phe Lys Lys Asp Gly 
    210                 215                 220                 


Leu Val Lys Arg Cys Met Gly Thr Val Thr Leu Asn Gln Ala Arg Gly 
225                 230                 235                 240 


Ser Phe Asp Ile Ser Cys Asp Lys Asp Asn Lys Arg Phe Ala Leu Leu 
                245                 250                 255     


Gly Asp Phe Phe Arg Lys Ser Lys Glu Lys Ile Gly Lys Glu Phe Lys 
            260                 265                 270         


Arg Ile Val Gln Arg Ile Lys Asp Phe Leu Arg Asn Leu Val Pro Arg 
        275                 280                 285             


Thr Glu Ser 
    290     


<210>  88
<211>  873
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Fusion protein

<400>  88
atgggccatc atcatcatca tcatatgtca cacactacac catggacaaa cccaggactc       60

gcagaaaact tcatgaacag tttcatgcaa ggcctgagct cgatgccagg tttcacggca      120

agccaattgg atgatatgtc aaccatcgca caatccatgg tacagtcaat acaatccttg      180

gcggcacaag gcaggacatc accgaataag ctgcaggccc ttaacatggc ttttgcatct      240

tcgatggcag aaatcgcggc atccgaagaa ggagggggaa gcctttccac caaaactagc      300

tctatagcca gtgcaatgtc caacgcgttt ctgcaaacaa ctggagtggt aaaccaaccg      360

ttcataaatg aaataactca gctcgttagc atgtttgctc aagcaggtat gaatgatgtc      420

agtgctggga attccctggt gccacgcggt tctcaggtcc tcagctacaa ggaagctgtg      480

cttcgtgcta tagatggcat caaccagcgg tcctcggatg ctaacctcta ccgcctcctg      540

gacctggacc ccaggcccac gatggatggg gacccagaca cgccaaagcc tgtgagcttc      600

acagtgaagg agacagtgtg ccccaggacg acacagcagt caccagagga ttgtgacttc      660

aagaaggacg ggctggtgaa gcggtgtatg gggacagtga ccctcaacca ggccaggggc      720

tcctttgaca tcagttgtga taaggataac aagagatttg ccctgctggg tgatttcttc      780

cggaaatcta aagagaagat tggcaaagag tttaaaagaa ttgtccagag aatcaaggat      840

tttttgcgga atcttgtacc caggacagag tcc                                   873


<210>  89
<211>  873
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Fusion protein

<400>  89
atgggccatc atcatcatca tcatatgtca cacactacac catggacaaa cccaggactc       60

gcagaaaact tcatgaacag tttcatgcaa ggcctgagct cgatgccagg tttcacggca      120

agccaattgg ataagatgtc aaccatcgca caatccatgg tacagtcaat acaatccttg      180

gcggcacaag gcaggacatc accgaatgac ctgcaggccc ttaacatggc ttttgcatct      240

tcgatggcag aaatcgcggc atccgaagaa ggagggggaa gcctttccac caaaactagc      300

tctatagcca gtgcaatgtc caacgcgttt ctgcaaacaa ctggagtggt aaaccaaccg      360

ttcataaatg aaataactca gctcgttagc atgtttgctc aagcaggtat gaatgatgtc      420

agtgctggga attccctggt gccacgcggt tctcaggtcc tcagctacaa ggaagctgtg      480

cttcgtgcta tagatggcat caaccagcgg tcctcggatg ctaacctcta ccgcctcctg      540

gacctggacc ccaggcccac gatggatggg gacccagaca cgccaaagcc tgtgagcttc      600

acagtgaagg agacagtgtg ccccaggacg acacagcagt caccagagga ttgtgacttc      660

aagaaggacg ggctggtgaa gcggtgtatg gggacagtga ccctcaacca ggccaggggc      720

tcctttgaca tcagttgtga taaggataac aagagatttg ccctgctggg tgatttcttc      780

cggaaatcta aagagaagat tggcaaagag tttaaaagaa ttgtccagag aatcaaggat      840

tttttgcgga atcttgtacc caggacagag tcc                                   873


<210>  90
<211>  787
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein

<400>  90

Met Gly His His His His His His Met Ser His Thr Thr Pro Trp Thr 
1               5                   10                  15      


Asn Pro Gly Leu Ala Glu Asn Phe Met Asn Ser Phe Met Gln Gly Leu 
            20                  25                  30          


Ser Ser Met Pro Gly Phe Thr Ala Ser Gln Leu Asp Lys Met Ser Thr 
        35                  40                  45              


Ile Ala Gln Ser Met Val Gln Ser Ile Gln Ser Leu Ala Ala Gln Gly 
    50                  55                  60                  


Arg Thr Ser Pro Asn Asp Leu Gln Ala Leu Asn Met Ala Phe Ala Ser 
65                  70                  75                  80  


Ser Met Ala Glu Ile Ala Ala Ser Glu Glu Gly Gly Gly Ser Leu Ser 
                85                  90                  95      


Thr Lys Thr Ser Ser Ile Ala Ser Ala Met Ser Asn Ala Phe Leu Gln 
            100                 105                 110         


Thr Thr Gly Val Val Asn Gln Pro Phe Ile Asn Glu Ile Thr Gln Leu 
        115                 120                 125             


Val Ser Met Phe Ala Gln Ala Gly Met Asn Asp Val Ser Ala Gly Asn 
    130                 135                 140                 


Ser Leu Val Pro Arg Gly Ser Asn Ser Val Glu Arg Lys Ile Tyr Ile 
145                 150                 155                 160 


Pro Leu Asn Lys Thr Ala Pro Cys Val Arg Leu Leu Asn Ala Thr His 
                165                 170                 175     


Gln Ile Gly Cys Gln Ser Ser Ile Ser Gly Asp Thr Gly Val Ile His 
            180                 185                 190         


Val Val Glu Lys Glu Glu Asp Leu Gln Trp Val Leu Thr Asp Gly Pro 
        195                 200                 205             


Asn Pro Pro Tyr Met Val Leu Leu Glu Ser Lys His Phe Thr Arg Asp 
    210                 215                 220                 


Leu Met Glu Lys Leu Lys Gly Arg Thr Ser Arg Ile Ala Gly Leu Ala 
225                 230                 235                 240 


Val Ser Leu Thr Lys Pro Ser Pro Ala Ser Gly Phe Ser Pro Ser Val 
                245                 250                 255     


Gln Cys Pro Asn Asp Gly Phe Gly Val Tyr Ser Asn Ser Tyr Gly Pro 
            260                 265                 270         


Glu Phe Ala His Cys Arg Glu Ile Gln Trp Asn Ser Leu Gly Asn Gly 
        275                 280                 285             


Leu Ala Tyr Glu Asp Phe Ser Phe Pro Ile Phe Leu Leu Glu Asp Glu 
    290                 295                 300                 


Asn Glu Thr Lys Val Ile Lys Gln Cys Tyr Gln Asp His Asn Leu Ser 
305                 310                 315                 320 


Gln Asn Gly Ser Ala Pro Thr Phe Pro Leu Cys Ala Met Gln Leu Phe 
                325                 330                 335     


Ser His Met His Ala Val Ile Ser Thr Ala Thr Cys Met Arg Arg Ser 
            340                 345                 350         


Ser Ile Gln Ser Thr Phe Ser Ile Asn Pro Glu Ile Val Cys Asp Pro 
        355                 360                 365             


Leu Ser Asp Tyr Asn Val Trp Ser Met Leu Lys Pro Ile Asn Thr Thr 
    370                 375                 380                 


Gly Thr Leu Lys Pro Asp Asp Arg Val Val Val Ala Ala Thr Arg Leu 
385                 390                 395                 400 


Asp Ser Arg Ser Phe Phe Trp Asn Val Ala Pro Gly Ala Glu Ser Ala 
                405                 410                 415     


Val Ala Ser Phe Val Thr Gln Leu Ala Ala Ala Glu Ala Leu Gln Lys 
            420                 425                 430         


Ala Pro Asp Val Thr Thr Leu Pro Arg Asn Val Met Phe Val Phe Phe 
        435                 440                 445             


Gln Gly Glu Thr Phe Asp Tyr Ile Gly Ser Ser Arg Met Val Tyr Asp 
    450                 455                 460                 


Met Glu Lys Gly Lys Phe Pro Val Gln Leu Glu Asn Val Asp Ser Phe 
465                 470                 475                 480 


Val Glu Leu Gly Gln Val Ala Leu Arg Thr Ser Leu Glu Leu Trp Met 
                485                 490                 495     


His Thr Asp Pro Val Ser Gln Lys Asn Glu Ser Val Arg Asn Gln Val 
            500                 505                 510         


Glu Asp Leu Leu Ala Thr Leu Glu Lys Ser Gly Ala Gly Val Pro Ala 
        515                 520                 525             


Val Ile Leu Arg Arg Pro Asn Gln Ser Gln Pro Leu Pro Pro Ser Ser 
    530                 535                 540                 


Leu Gln Arg Phe Leu Arg Ala Arg Asn Ile Ser Gly Val Val Leu Ala 
545                 550                 555                 560 


Asp His Ser Gly Ala Phe His Asn Lys Tyr Tyr Gln Ser Ile Tyr Asp 
                565                 570                 575     


Thr Ala Glu Asn Ile Asn Val Ser Tyr Pro Glu Trp Leu Ser Pro Glu 
            580                 585                 590         


Glu Asp Leu Asn Phe Val Thr Asp Thr Ala Lys Ala Leu Ala Asp Val 
        595                 600                 605             


Ala Thr Val Leu Gly Arg Ala Leu Tyr Glu Leu Ala Gly Gly Thr Asn 
    610                 615                 620                 


Phe Ser Asp Thr Val Gln Ala Asp Pro Gln Thr Val Thr Arg Leu Leu 
625                 630                 635                 640 


Tyr Gly Phe Leu Ile Lys Ala Asn Asn Ser Trp Phe Gln Ser Ile Leu 
                645                 650                 655     


Arg Gln Asp Leu Arg Ser Tyr Leu Gly Asp Gly Pro Leu Gln His Tyr 
            660                 665                 670         


Ile Ala Val Ser Ser Pro Thr Asn Thr Thr Tyr Val Val Gln Tyr Ala 
        675                 680                 685             


Leu Ala Asn Leu Thr Gly Thr Val Val Asn Leu Thr Arg Glu Gln Cys 
    690                 695                 700                 


Gln Asp Pro Ser Lys Val Pro Ser Glu Asn Lys Asp Leu Tyr Glu Tyr 
705                 710                 715                 720 


Ser Trp Val Gln Gly Pro Leu His Ser Asn Glu Thr Asp Arg Leu Pro 
                725                 730                 735     


Arg Cys Val Arg Ser Thr Ala Arg Leu Ala Arg Ala Leu Ser Pro Ala 
            740                 745                 750         


Phe Glu Leu Ser Gln Trp Ser Ser Thr Glu Tyr Ser Thr Trp Thr Glu 
        755                 760                 765             


Ser Arg Trp Lys Asp Ile Arg Ala Arg Ile Phe Leu Ile Ala Ser Lys 
    770                 775                 780                 


Glu Leu Glu 
785         


<210>  91
<211>  2361
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Fusion protein

<400>  91
atgggccatc atcatcatca tcatatgtca cacactacac catggacaaa cccaggactc       60

gcagaaaact tcatgaacag tttcatgcaa ggcctgagct cgatgccagg tttcacggca      120

agccaattgg ataagatgtc aaccatcgca caatccatgg tacagtcaat acaatccttg      180

gcggcacaag gcaggacatc accgaatgac ctgcaggccc ttaacatggc ttttgcatct      240

tcgatggcag aaatcgcggc atccgaagaa ggagggggaa gcctttccac caaaactagc      300

tctatagcca gtgcaatgtc caacgcgttt ctgcaaacaa ctggagtggt aaaccaaccg      360

ttcataaatg aaataactca gctcgttagc atgtttgctc aagcaggtat gaatgatgtc      420

agtgctggga attccctggt gccacgcggt tctaactcag tggagaggaa gatatatatc      480

cccttaaata aaacagctcc ctgtgttcgc ctgctcaacg ccactcatca gattggctgc      540

cagtcttcaa ttagtggaga cacaggggtt atccacgtag tagagaaaga ggaggaccta      600

cagtgggtat tgactgatgg ccccaacccc ccttacatgg ttctgctgga gagcaagcat      660

tttaccaggg atttaatgga gaagctgaaa gggagaacca gccgaattgc tggtcttgca      720

gtgtccttga ccaagcccag tcctgcctca ggcttctctc ctagtgtaca gtgcccaaat      780

gatgggtttg gtgtttactc caattcctat gggccagagt ttgctcactg cagagaaata      840

cagtggaatt cgctgggcaa tggtttggct tatgaagact ttagtttccc catctttctt      900

cttgaagatg aaaatgaaac caaagtcatc aagcagtgct atcaagatca caacctgagt      960

cagaatggct cagcaccaac cttcccacta tgtgccatgc agctcttttc acacatgcat     1020

gctgtcatca gcactgccac ctgcatgcgg cgcagctcca tccaaagcac cttcagcatc     1080

aacccagaaa tcgtctgtga ccccctgtct gattacaatg tgtggagcat gctaaagcct     1140

ataaatacaa ctgggacatt aaagcctgac gacagggttg tggttgctgc cacccggctg     1200

gatagtcgtt cctttttctg gaatgtggcc ccaggggctg aaagcgcagt ggcttccttt     1260

gtcacccagc tggctgctgc tgaagctttg caaaaggcac ctgatgtgac caccctgccc     1320

cgcaatgtca tgtttgtctt ctttcaaggg gaaacttttg actacattgg cagctcgagg     1380

atggtctacg atatggagaa gggcaagttt cccgtgcagt tagagaatgt tgactcattt     1440

gtggagctgg gacaggtggc cttaagaact tcattagagc tttggatgca cacagatcct     1500

gtttctcaga aaaatgagtc tgtacggaac caggtggagg atctcctggc cacattggag     1560

aagagtggtg ctggtgtccc tgctgtcatc ctcaggaggc caaatcagtc ccagcctctc     1620

ccaccatctt ccctgcagcg atttcttcga gctcgaaaca tctctggcgt tgttctggct     1680

gaccactctg gtgccttcca taacaaatat taccagagta tttacgacac tgctgagaac     1740

attaatgtga gctatcccga atggctgagc cctgaagagg acctgaactt tgtaacagac     1800

actgccaagg ccctggcaga tgtggccacg gtgctgggac gtgctctgta tgagcttgca     1860

ggaggaacca acttcagcga cacagttcag gctgatcccc aaacggttac ccgcctgctc     1920

tatgggttcc tgattaaagc caacaactca tggttccagt ctatcctcag gcaggaccta     1980

aggtcctact tgggtgacgg gcctcttcaa cattacatcg ctgtctccag ccccaccaac     2040

accacttatg ttgtacagta tgccttggca aatttgactg gcacagtggt caacctcacc     2100

cgagagcagt gccaggatcc aagtaaagtc ccaagtgaaa acaaggatct gtatgagtac     2160

tcatgggtcc agggcccttt gcattctaat gagacggacc gactcccccg gtgtgtgcgt     2220

tctactgcac gattagccag ggccttgtct cctgcctttg aactgagtca gtggagctct     2280

actgaatact ctacatggac tgagagccgc tggaaagata tccgtgcccg gatatttctc     2340

atcgccagca aagagcttga g                                               2361


<210>  92
<211>  390
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein

<400>  92

Met Gly His His His His His His Met Ser His Thr Thr Pro Trp Thr 
1               5                   10                  15      


Asn Pro Gly Leu Ala Glu Asn Phe Met Asn Ser Phe Met Gln Gly Leu 
            20                  25                  30          


Ser Ser Met Pro Gly Phe Thr Ala Ser Gln Leu Asp Asp Met Ser Thr 
        35                  40                  45              


Ile Ala Gln Ser Met Val Gln Ser Ile Gln Ser Leu Ala Ala Gln Gly 
    50                  55                  60                  


Arg Thr Ser Pro Asn Lys Leu Gln Ala Leu Asn Met Ala Phe Ala Ser 
65                  70                  75                  80  


Ser Met Ala Glu Ile Ala Ala Ser Glu Glu Gly Gly Gly Ser Leu Ser 
                85                  90                  95      


Thr Lys Thr Ser Ser Ile Ala Ser Ala Met Ser Asn Ala Phe Leu Gln 
            100                 105                 110         


Thr Thr Gly Val Val Asn Gln Pro Phe Ile Asn Glu Ile Thr Gln Leu 
        115                 120                 125             


Val Ser Met Phe Ala Gln Ala Gly Met Asn Asp Val Ser Ala Gly Asn 
    130                 135                 140                 


Ser Leu Val Pro Arg Gly Ser Lys Gly Glu Glu Leu Phe Thr Gly Val 
145                 150                 155                 160 


Val Pro Ile Leu Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe 
                165                 170                 175     


Ser Val Ser Gly Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr 
            180                 185                 190         


Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr 
        195                 200                 205             


Leu Val Thr Thr Leu Thr Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro 
    210                 215                 220                 


Asp His Met Lys Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly 
225                 230                 235                 240 


Tyr Val Gln Glu Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys 
                245                 250                 255     


Thr Arg Ala Glu Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile 
            260                 265                 270         


Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His 
        275                 280                 285             


Lys Leu Glu Tyr Asn Tyr Asn Ser His Asn Val Tyr Ile Met Ala Asp 
    290                 295                 300                 


Lys Gln Lys Asn Gly Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile 
305                 310                 315                 320 


Glu Asp Gly Ser Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro 
                325                 330                 335     


Ile Gly Asp Gly Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr 
            340                 345                 350         


Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val 
        355                 360                 365             


Leu Leu Glu Phe Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu 
    370                 375                 380                 


Leu Tyr Lys Leu Ile Asn 
385                 390 


<210>  93
<211>  390
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein

<400>  93

Met Gly His His His His His His Met Ser His Thr Thr Pro Trp Thr 
1               5                   10                  15      


Asn Pro Gly Leu Ala Glu Asn Phe Met Asn Ser Phe Met Gln Gly Leu 
            20                  25                  30          


Ser Ser Met Pro Gly Phe Thr Ala Ser Gln Leu Asp Lys Met Ser Thr 
        35                  40                  45              


Ile Ala Gln Ser Met Val Gln Ser Ile Gln Ser Leu Ala Ala Gln Gly 
    50                  55                  60                  


Arg Thr Ser Pro Asn Asp Leu Gln Ala Leu Asn Met Ala Phe Ala Ser 
65                  70                  75                  80  


Ser Met Ala Glu Ile Ala Ala Ser Glu Glu Gly Gly Gly Ser Leu Ser 
                85                  90                  95      


Thr Lys Thr Ser Ser Ile Ala Ser Ala Met Ser Asn Ala Phe Leu Gln 
            100                 105                 110         


Thr Thr Gly Val Val Asn Gln Pro Phe Ile Asn Glu Ile Thr Gln Leu 
        115                 120                 125             


Val Ser Met Phe Ala Gln Ala Gly Met Asn Asp Val Ser Ala Gly Asn 
    130                 135                 140                 


Ser Leu Val Pro Arg Gly Ser Lys Gly Glu Glu Leu Phe Thr Gly Val 
145                 150                 155                 160 


Val Pro Ile Leu Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe 
                165                 170                 175     


Ser Val Ser Gly Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr 
            180                 185                 190         


Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr 
        195                 200                 205             


Leu Val Thr Thr Leu Thr Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro 
    210                 215                 220                 


Asp His Met Lys Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly 
225                 230                 235                 240 


Tyr Val Gln Glu Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys 
                245                 250                 255     


Thr Arg Ala Glu Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile 
            260                 265                 270         


Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His 
        275                 280                 285             


Lys Leu Glu Tyr Asn Tyr Asn Ser His Asn Val Tyr Ile Met Ala Asp 
    290                 295                 300                 


Lys Gln Lys Asn Gly Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile 
305                 310                 315                 320 


Glu Asp Gly Ser Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro 
                325                 330                 335     


Ile Gly Asp Gly Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr 
            340                 345                 350         


Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val 
        355                 360                 365             


Leu Leu Glu Phe Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu 
    370                 375                 380                 


Leu Tyr Lys Leu Ile Asn 
385                 390 


<210>  94
<211>  1170
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Fusion protein

<400>  94
atgggccatc atcatcatca tcatatgtca cacactacac catggacaaa cccaggactc       60

gcagaaaact tcatgaacag tttcatgcaa ggcctgagct cgatgccagg tttcacggca      120

agccaattgg atgatatgtc aaccatcgca caatccatgg tacagtcaat acaatccttg      180

gcggcacaag gcaggacatc accgaataag ctgcaggccc ttaacatggc ttttgcatct      240

tcgatggcag aaatcgcggc atccgaagaa ggagggggaa gcctttccac caaaactagc      300

tctatagcca gtgcaatgtc caacgcgttt ctgcaaacaa ctggagtggt aaaccaaccg      360

ttcataaatg aaataactca gctcgttagc atgtttgctc aagcaggtat gaatgatgtc      420

agtgctggga attccctggt gccacgcggt tctaagggcg aggagctgtt caccggggtg      480

gtgcccatcc tggtcgagct ggacggcgac gtaaacggcc acaagttcag cgtgtccggc      540

gagggcgagg gcgatgccac ctacggcaag ctgaccctga agttcatctg caccaccggc      600

aagctgcccg tgccctggcc caccctcgtg accaccctga cctacggcgt gcagtgcttc      660

agccgctacc ccgaccacat gaagcagcac gacttcttca agtccgccat gcccgaaggc      720

tacgtccagg agcgcaccat cttcttcaag gacgacggca actacaagac ccgcgccgag      780

gtgaagttcg agggcgacac cctggtgaac cgcatcgagc tgaagggcat cgacttcaag      840

gaggacggca acatcctggg gcacaagctg gagtacaact acaacagcca caacgtctat      900

atcatggccg acaagcagaa gaacggcatc aaggtgaact tcaagatccg ccacaacatc      960

gaggacggca gcgtgcagct cgccgaccac taccagcaga acacccccat cggcgacggc     1020

cccgtgctgc tgcccgacaa ccactacctg agcacccagt ccgccctgag caaagacccc     1080

aacgagaagc gcgatcacat ggtcctgctg gagttcgtga ccgccgccgg gatcactctc     1140

ggcatggacg agctgtacaa gttaattaac                                      1170


<210>  95
<211>  1170
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Fusion protein

<400>  95
atgggccatc atcatcatca tcatatgtca cacactacac catggacaaa cccaggactc       60

gcagaaaact tcatgaacag tttcatgcaa ggcctgagct cgatgccagg tttcacggca      120

agccaattgg ataagatgtc aaccatcgca caatccatgg tacagtcaat acaatccttg      180

gcggcacaag gcaggacatc accgaatgac ctgcaggccc ttaacatggc ttttgcatct      240

tcgatggcag aaatcgcggc atccgaagaa ggagggggaa gcctttccac caaaactagc      300

tctatagcca gtgcaatgtc caacgcgttt ctgcaaacaa ctggagtggt aaaccaaccg      360

ttcataaatg aaataactca gctcgttagc atgtttgctc aagcaggtat gaatgatgtc      420

agtgctggga attccctggt gccacgcggt tctaagggcg aggagctgtt caccggggtg      480

gtgcccatcc tggtcgagct ggacggcgac gtaaacggcc acaagttcag cgtgtccggc      540

gagggcgagg gcgatgccac ctacggcaag ctgaccctga agttcatctg caccaccggc      600

aagctgcccg tgccctggcc caccctcgtg accaccctga cctacggcgt gcagtgcttc      660

agccgctacc ccgaccacat gaagcagcac gacttcttca agtccgccat gcccgaaggc      720

tacgtccagg agcgcaccat cttcttcaag gacgacggca actacaagac ccgcgccgag      780

gtgaagttcg agggcgacac cctggtgaac cgcatcgagc tgaagggcat cgacttcaag      840

gaggacggca acatcctggg gcacaagctg gagtacaact acaacagcca caacgtctat      900

atcatggccg acaagcagaa gaacggcatc aaggtgaact tcaagatccg ccacaacatc      960

gaggacggca gcgtgcagct cgccgaccac taccagcaga acacccccat cggcgacggc     1020

cccgtgctgc tgcccgacaa ccactacctg agcacccagt ccgccctgag caaagacccc     1080

aacgagaagc gcgatcacat ggtcctgctg gagttcgtga ccgccgccgg gatcactctc     1140

ggcatggacg agctgtacaa gttaattaac                                      1170


<210>  96
<211>  133
<212>  PRT
<213>  Araneus ventricosus

<400>  96

Gly Ser Gly Asn Ser Gln Pro Ile Trp Thr Asn Pro Asn Ala Ala Met 
1               5                   10                  15      


Thr Met Thr Asn Asn Leu Val Gln Cys Ala Ser Arg Ser Gly Val Leu 
            20                  25                  30          


Thr Ala Asp Gln Met Asp Asp Met Gly Met Met Ala Asp Ser Val Asn 
        35                  40                  45              


Ser Gln Met Gln Lys Met Gly Pro Asn Pro Pro Gln His Arg Leu Arg 
    50                  55                  60                  


Ala Met Asn Thr Ala Met Ala Ala Glu Val Ala Glu Val Val Ala Thr 
65                  70                  75                  80  


Ser Pro Pro Gln Ser Tyr Ser Ala Val Leu Asn Thr Ile Gly Ala Cys 
                85                  90                  95      


Leu Arg Glu Ser Met Met Gln Ala Thr Gly Ser Val Asp Asn Ala Phe 
            100                 105                 110         


Thr Asn Glu Val Met Gln Leu Val Lys Met Leu Ser Ala Asp Ser Ala 
        115                 120                 125             


Asn Glu Val Ser Thr 
    130             


<210>  97
<211>  129
<212>  PRT
<213>  Latrodectus hesperus

<400>  97

Asp Ala Ala Ser Val Trp Asp Ser Thr Ala Thr Ala Glu Ala Phe Ile 
1               5                   10                  15      


Gly Ser Phe Asn Ser Gly Met Glu Arg Ser Gly Val Leu Ser Arg Ser 
            20                  25                  30          


Gln Met Asp Asp Ile Ser Ser Ile Ser Asp Thr Ile Ile Ser Ala Ile 
        35                  40                  45              


Glu Arg Asn Pro Asn Asn Ser Lys Ser Lys Leu Gln Ala Leu Asn Met 
    50                  55                  60                  


Ala Phe Ala Ser Ser Val Ser Glu Ile Ala Phe Ser Glu Asn Asn Gly 
65                  70                  75                  80  


Ile Ser Asn Ser Ala Lys Ile Gln Ala Ile Ile Asp Ala Leu Arg Gly 
                85                  90                  95      


Ala Phe Leu Gln Thr Ile Gly Thr Val Asp Gln Thr Phe Leu Asn Glu 
            100                 105                 110         


Ile Ser Ser Leu Val Lys Met Phe Ser Gln Val Ser Ala Glu Asn Ala 
        115                 120                 125             


Val 
    


<210>  98
<211>  128
<212>  PRT
<213>  Uloborus diversus

<400>  98

Gln Gly Ala Ser Val Trp Ser Ser Pro Gln Met Ala Glu Asn Phe Met 
1               5                   10                  15      


Asn Gly Phe Ser Met Ala Leu Ser Gln Ala Gly Ala Phe Ser Gly Gln 
            20                  25                  30          


Glu Met Lys Asp Phe Asp Asp Val Arg Asp Ile Met Asn Ser Ala Met 
        35                  40                  45              


Asp Lys Met Ile Arg Ser Gly Lys Ser Gly Arg Gly Ala Met Arg Ala 
    50                  55                  60                  


Met Asn Ala Ala Phe Gly Ser Ala Ile Ala Glu Ile Val Ala Ala Asn 
65                  70                  75                  80  


Gly Gly Lys Glu Tyr Gln Ile Gly Ala Val Leu Asp Ala Val Thr Asn 
                85                  90                  95      


Thr Leu Leu Gln Leu Thr Gly Asn Ala Asp Asn Gly Phe Leu Asn Glu 
            100                 105                 110         


Ile Ser Arg Leu Ile Thr Leu Phe Ser Ser Val Glu Ala Asn Asp Val 
        115                 120                 125             


<210>  99
<211>  128
<212>  PRT
<213>  Metepeira grandiosa

<400>  99

Ala His Gly His Ile Trp Gly Thr Pro Gly Ala Gly Lys Ser Val Thr 
1               5                   10                  15      


Gly Ser Ile Val Gln Cys Ala Gly Gln Ser Gly Val Phe Ser Gly Asp 
            20                  25                  30          


Gln Met Gln Asp Leu Gly Asp Met Ala Asp Ala Val Asn Arg Gln Leu 
        35                  40                  45              


Asp Arg Leu Gly Pro Asn Ala Pro Asp His Arg Leu Lys Gly Val Thr 
    50                  55                  60                  


Thr Met Met Ala Ala Gly Ile Ala Asp Ala Ala Val Asn Ser Pro Gly 
65                  70                  75                  80  


Gln Ser Leu Asp Val Met Ile Asn Thr Ile Ser Gly Cys Met Thr Gln 
                85                  90                  95      


Ala Met Ser Gln Ala Val Gly Tyr Val Asp Gln Thr Leu Ile Arg Glu 
            100                 105                 110         


Val Ala Glu Met Val Asn Met Leu Ala Asn Glu Asn Ala Asn Ala Val 
        115                 120                 125             


<210>  100
<211>  176
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein

<400>  100

Met Gly His His His His His His Met Ser His Thr Thr Pro Trp Thr 
1               5                   10                  15      


Asn Pro Gly Leu Ala Glu Asn Phe Met Asn Ser Phe Met Gln Gly Leu 
            20                  25                  30          


Ser Ser Met Pro Gly Phe Thr Ala Ser Gln Leu Asp Asp Met Ser Thr 
        35                  40                  45              


Ile Ala Gln Ser Met Val Gln Ser Ile Gln Ser Leu Ala Ala Gln Gly 
    50                  55                  60                  


Arg Thr Ser Pro Asn Lys Leu Gln Ala Leu Asn Met Arg Phe Ala Ser 
65                  70                  75                  80  


Ser Met Ala Glu Ile Ala Ala Ser Glu Glu Gly Gly Gly Ser Leu Ser 
                85                  90                  95      


Thr Lys Thr Ser Ser Ile Ala Ser Ala Met Ser Asn Ala Phe Leu Gln 
            100                 105                 110         


Thr Thr Gly Val Val Asn Gln Pro Phe Ile Asn Glu Ile Thr Gln Leu 
        115                 120                 125             


Val Ser Met Phe Ala Gln Ala Gly Met Asn Asp Val Ser Ala Met Ile 
    130                 135                 140                 


Pro Ser Ser Pro Val His Leu Lys Arg Leu Lys Leu Leu Leu Leu Leu 
145                 150                 155                 160 


Leu Leu Leu Ile Leu Leu Leu Ile Leu Gly Ala Leu Leu Leu Gly Leu 
                165                 170                 175     


<210>  101
<211>  426
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein

<400>  101

Met Gly Ser Ser Gly His His His His His His Met Gly Gly Gly Gly 
1               5                   10                  15      


Ser Ser His Thr Thr Pro Trp Thr Asn Pro Gly Leu Ala Glu Asn Phe 
            20                  25                  30          


Met Asn Ser Phe Met Gln Gly Leu Ser Ser Met Pro Gly Phe Thr Ala 
        35                  40                  45              


Ser Gln Leu Asp Lys Met Ser Thr Ile Ala Gln Ser Met Val Gln Ser 
    50                  55                  60                  


Ile Gln Ser Leu Ala Ala Gln Gly Arg Thr Ser Pro Asn Asp Leu Gln 
65                  70                  75                  80  


Ala Leu Asn Met Ala Phe Ala Ser Ser Met Ala Glu Ile Ala Ala Ser 
                85                  90                  95      


Glu Glu Gly Gly Gly Ser Leu Ser Thr Lys Thr Ser Ser Ile Ala Ser 
            100                 105                 110         


Ala Met Ser Asn Ala Phe Leu Gln Thr Thr Gly Val Val Asn Gln Pro 
        115                 120                 125             


Phe Ile Asn Glu Ile Thr Gln Leu Val Ser Met Phe Ala Gln Ala Gly 
    130                 135                 140                 


Met Asn Asp Val Leu Glu Ala Leu Phe Gln Gly Pro Asn Ser Cys Thr 
145                 150                 155                 160 


Gly Arg Gly Asp Ser Pro Ala Cys Gly Ser Ala Ser Gly Gln Gly Gly 
                165                 170                 175     


Tyr Gly Gly Leu Gly Gln Gly Gly Tyr Gly Gln Gly Ala Gly Ser Ser 
            180                 185                 190         


Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Gly Gly Gln Gly 
        195                 200                 205             


Gly Gln Gly Gln Gly Gly Tyr Gly Gln Gly Ser Gly Gly Ser Ala Ala 
    210                 215                 220                 


Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Gly Arg Gly 
225                 230                 235                 240 


Gln Gly Gly Tyr Gly Gln Gly Ser Gly Gly Asn Ala Ala Ala Ala Ala 
                245                 250                 255     


Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Gly Gln Gly Gly Gln Gly 
            260                 265                 270         


Gly Tyr Gly Arg Gln Ser Gln Gly Ala Gly Ser Ala Ala Ala Ala Ala 
        275                 280                 285             


Ala Ala Ala Ala Ala Ala Ala Ala Ala Gly Ser Gly Gln Gly Gly Tyr 
    290                 295                 300                 


Gly Gly Gln Gly Gln Gly Gly Tyr Gly Gln Ser Ser Ala Ser Ala Ser 
305                 310                 315                 320 


Ala Ala Ala Ser Ala Ala Gly Ser Tyr Ala Gly Ala Val Asn Arg Leu 
                325                 330                 335     


Ser Ser Ala Glu Ala Ala Ser Arg Val Ser Ser Asn Ile Ala Ala Ile 
            340                 345                 350         


Ala Ser Gly Gly Ala Ser Ala Leu Pro Ser Val Ile Ser Asn Ile Tyr 
        355                 360                 365             


Ser Gly Val Val Ala Ser Gly Val Ser Ser Asn Glu Ala Leu Ile Gln 
    370                 375                 380                 


Ala Leu Leu Glu Leu Leu Ser Ala Leu Val His Val Leu Ser Ser Ala 
385                 390                 395                 400 


Ser Ile Gly Asn Val Ser Ser Val Gly Val Asp Ser Thr Leu Asn Val 
                405                 410                 415     


Val Gln Asp Ser Val Gly Gln Tyr Val Gly 
            420                 425     


<210>  102
<211>  353
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein

<400>  102

Met Gly Ser Ser Gly His His His His His His Met Gly Gly Gly Gly 
1               5                   10                  15      


Ser Val Asp Asn Lys Phe Asn Lys Glu Gln Gln Asn Ala Phe Tyr Glu 
            20                  25                  30          


Ile Leu His Leu Pro Asn Leu Asn Glu Glu Gln Arg Asn Ala Phe Ile 
        35                  40                  45              


Gln Ser Leu Lys Asp Asp Pro Ser Gln Ser Ala Asn Leu Leu Ala Glu 
    50                  55                  60                  


Ala Lys Lys Leu Asn Asp Ala Gln Ala Pro Lys Leu Glu Ala Leu Phe 
65                  70                  75                  80  


Gln Gly Pro Asn Ser Cys Thr Gly Arg Gly Asp Ser Pro Ala Cys Gly 
                85                  90                  95      


Ser Ala Ser Gly Gln Gly Gly Tyr Gly Gly Leu Gly Gln Gly Gly Tyr 
            100                 105                 110         


Gly Gln Gly Ala Gly Ser Ser Ala Ala Ala Ala Ala Ala Ala Ala Ala 
        115                 120                 125             


Ala Ala Ala Gly Gly Gln Gly Gly Gln Gly Gln Gly Gly Tyr Gly Gln 
    130                 135                 140                 


Gly Ser Gly Gly Ser Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala 
145                 150                 155                 160 


Ala Ala Ala Ala Gly Arg Gly Gln Gly Gly Tyr Gly Gln Gly Ser Gly 
                165                 170                 175     


Gly Asn Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala 
            180                 185                 190         


Ala Gly Gln Gly Gly Gln Gly Gly Tyr Gly Arg Gln Ser Gln Gly Ala 
        195                 200                 205             


Gly Ser Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala 
    210                 215                 220                 


Gly Ser Gly Gln Gly Gly Tyr Gly Gly Gln Gly Gln Gly Gly Tyr Gly 
225                 230                 235                 240 


Gln Ser Ser Ala Ser Ala Ser Ala Ala Ala Ser Ala Ala Gly Ser Tyr 
                245                 250                 255     


Ala Gly Ala Val Asn Arg Leu Ser Ser Ala Glu Ala Ala Ser Arg Val 
            260                 265                 270         


Ser Ser Asn Ile Ala Ala Ile Ala Ser Gly Gly Ala Ser Ala Leu Pro 
        275                 280                 285             


Ser Val Ile Ser Asn Ile Tyr Ser Gly Val Val Ala Ser Gly Val Ser 
    290                 295                 300                 


Ser Asn Glu Ala Leu Ile Gln Ala Leu Leu Glu Leu Leu Ser Ala Leu 
305                 310                 315                 320 


Val His Val Leu Ser Ser Ala Ser Ile Gly Asn Val Ser Ser Val Gly 
                325                 330                 335     


Val Asp Ser Thr Leu Asn Val Val Gln Asp Ser Val Gly Gln Tyr Val 
            340                 345                 350         


Gly 
    


<210>  103
<211>  431
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein

<400>  103

Met Gly Ser Ser Gly His His His His His His Met Gly Gly Gly Gly 
1               5                   10                  15      


Ser Ser His Thr Thr Pro Trp Thr Asn Pro Gly Leu Ala Glu Asn Phe 
            20                  25                  30          


Met Asn Ser Phe Met Gln Gly Leu Ser Ser Met Pro Gly Phe Thr Ala 
        35                  40                  45              


Ser Gln Leu Asp Lys Met Ser Thr Ile Ala Gln Ser Met Val Gln Ser 
    50                  55                  60                  


Ile Gln Ser Leu Ala Ala Gln Gly Arg Thr Ser Pro Asn Asp Leu Gln 
65                  70                  75                  80  


Ala Leu Asn Met Ala Phe Ala Ser Ser Met Ala Glu Ile Ala Ala Ser 
                85                  90                  95      


Glu Glu Gly Gly Gly Ser Leu Ser Thr Lys Thr Ser Ser Ile Ala Ser 
            100                 105                 110         


Ala Met Ser Asn Ala Phe Leu Gln Thr Thr Gly Val Val Asn Gln Pro 
        115                 120                 125             


Phe Ile Asn Glu Ile Thr Gln Leu Val Ser Met Phe Ala Gln Ala Gly 
    130                 135                 140                 


Met Asn Asp Val Leu Glu Ala Leu Phe Gln Gly Pro Asn Ser Cys Thr 
145                 150                 155                 160 


Gly Arg Gly Asp Ser Pro Ala Cys Gly Ser Ala Ser Gly Gln Gly Gly 
                165                 170                 175     


Tyr Gly Gly Leu Gly Gln Gly Gly Tyr Gly Gln Gly Ala Gly Ser Ser 
            180                 185                 190         


Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Gly Gly Gln Gly 
        195                 200                 205             


Gly Gln Gly Gln Gly Gly Tyr Gly Gln Gly Ser Gly Gly Ser Ala Ala 
    210                 215                 220                 


Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Gly Arg Gly 
225                 230                 235                 240 


Gln Gly Gly Tyr Gly Gln Gly Ser Gly Gly Asn Ala Ala Ala Ala Ala 
                245                 250                 255     


Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Gly Gln Gly Gly Gln Gly 
            260                 265                 270         


Gly Tyr Gly Arg Gln Ser Gln Gly Ala Gly Ser Ala Ala Ala Ala Ala 
        275                 280                 285             


Ala Ala Ala Ala Ala Ala Ala Ala Ala Gly Ser Gly Gln Gly Gly Tyr 
    290                 295                 300                 


Gly Gly Gln Gly Gln Gly Gly Tyr Gly Gln Ser Ser Ala Ser Ala Ser 
305                 310                 315                 320 


Ala Ala Ala Ser Ala Ala Ser Thr Val Ala Asn Ser Val Ser Arg Leu 
                325                 330                 335     


Ser Ser Pro Ser Ala Val Ser Arg Val Ser Ser Ala Val Ser Ser Leu 
            340                 345                 350         


Val Ser Asn Gly Gln Val Asn Met Ala Ala Leu Pro Asn Ile Ile Ser 
        355                 360                 365             


Asn Ile Ser Ser Ser Val Ser Ala Ser Ala Pro Gly Ala Ser Gly Cys 
    370                 375                 380                 


Glu Val Ile Val Gln Ala Leu Leu Glu Val Ile Thr Ala Leu Val Gln 
385                 390                 395                 400 


Ile Val Ser Ser Ser Ser Val Gly Tyr Ile Asn Pro Ser Ala Val Asn 
                405                 410                 415     


Gln Ile Thr Asn Val Val Ala Asn Ala Met Ala Gln Val Met Gly 
            420                 425                 430     


<210>  104
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein

<400>  104

Met Gly Ser Ser Gly His His His His His His Met Gly Gly Gly Gly 
1               5                   10                  15      


Ser Val Asp Asn Lys Phe Asn Lys Glu Gln Gln Asn Ala Phe Tyr Glu 
            20                  25                  30          


Ile Leu His Leu Pro Asn Leu Asn Glu Glu Gln Arg Asn Ala Phe Ile 
        35                  40                  45              


Gln Ser Leu Lys Asp Asp Pro Ser Gln Ser Ala Asn Leu Leu Ala Glu 
    50                  55                  60                  


Ala Lys Lys Leu Asn Asp Ala Gln Ala Pro Lys Leu Glu Ala Leu Phe 
65                  70                  75                  80  


Gln Gly Pro Asn Ser Cys Thr Gly Arg Gly Asp Ser Pro Ala Cys Gly 
                85                  90                  95      


Ser Ala Ser Gly Gln Gly Gly Tyr Gly Gly Leu Gly Gln Gly Gly Tyr 
            100                 105                 110         


Gly Gln Gly Ala Gly Ser Ser Ala Ala Ala Ala Ala Ala Ala Ala Ala 
        115                 120                 125             


Ala Ala Ala Gly Gly Gln Gly Gly Gln Gly Gln Gly Gly Tyr Gly Gln 
    130                 135                 140                 


Gly Ser Gly Gly Ser Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala 
145                 150                 155                 160 


Ala Ala Ala Ala Gly Arg Gly Gln Gly Gly Tyr Gly Gln Gly Ser Gly 
                165                 170                 175     


Gly Asn Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala 
            180                 185                 190         


Ala Gly Gln Gly Gly Gln Gly Gly Tyr Gly Arg Gln Ser Gln Gly Ala 
        195                 200                 205             


Gly Ser Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala 
    210                 215                 220                 


Gly Ser Gly Gln Gly Gly Tyr Gly Gly Gln Gly Gln Gly Gly Tyr Gly 
225                 230                 235                 240 


Gln Ser Ser Ala Ser Ala Ser Ala Ala Ala Ser Ala Ala Ser Thr Val 
                245                 250                 255     


Ala Asn Ser Val Ser Arg Leu Ser Ser Pro Ser Ala Val Ser Arg Val 
            260                 265                 270         


Ser Ser Ala Val Ser Ser Leu Val Ser Asn Gly Gln Val Asn Met Ala 
        275                 280                 285             


Ala Leu Pro Asn Ile Ile Ser Asn Ile Ser Ser Ser Val Ser Ala Ser 
    290                 295                 300                 


Ala Pro Gly Ala Ser Gly Cys Glu Val Ile Val Gln Ala Leu Leu Glu 
305                 310                 315                 320 


Val Ile Thr Ala Leu Val Gln Ile Val Ser Ser Ser Ser Val Gly Tyr 
                325                 330                 335     


Ile Asn Pro Ser Ala Val Asn Gln Ile Thr Asn Val Val Ala Asn Ala 
            340                 345                 350         


Met Ala Gln Val Met Gly 
        355             


<210>  105
<211>  661
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein

<400>  105

Met Gly Ser Ser Gly His His His His His His Met Gly Gly Gly Gly 
1               5                   10                  15      


Ser Ser His Thr Thr Pro Trp Thr Asn Pro Gly Leu Ala Glu Asn Phe 
            20                  25                  30          


Met Asn Ser Phe Met Gln Gly Leu Ser Ser Met Pro Gly Phe Thr Ala 
        35                  40                  45              


Ser Gln Leu Asp Lys Met Ser Thr Ile Ala Gln Ser Met Val Gln Ser 
    50                  55                  60                  


Ile Gln Ser Leu Ala Ala Gln Gly Arg Thr Ser Pro Asn Asp Leu Gln 
65                  70                  75                  80  


Ala Leu Asn Met Ala Phe Ala Ser Ser Met Ala Glu Ile Ala Ala Ser 
                85                  90                  95      


Glu Glu Gly Gly Gly Ser Leu Ser Thr Lys Thr Ser Ser Ile Ala Ser 
            100                 105                 110         


Ala Met Ser Asn Ala Phe Leu Gln Thr Thr Gly Val Val Asn Gln Pro 
        115                 120                 125             


Phe Ile Asn Glu Ile Thr Gln Leu Val Ser Met Phe Ala Gln Ala Gly 
    130                 135                 140                 


Met Asn Asp Val Leu Glu Ala Leu Phe Gln Gly Pro Asn Ser Glu Val 
145                 150                 155                 160 


Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
                165                 170                 175     


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met 
            180                 185                 190         


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Gly 
        195                 200                 205             


Ile Gly Ser Tyr Gly Gly Gly Thr Tyr Tyr Ala Asp Ser Val Lys Gly 
    210                 215                 220                 


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
225                 230                 235                 240 


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
                245                 250                 255     


Tyr Val Asn Phe Gly Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            260                 265                 270         


Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             


Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser 
    290                 295                 300                 


Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser 
305                 310                 315                 320 


Ser Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu 
                325                 330                 335     


Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe 
            340                 345                 350         


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu 
        355                 360                 365             


Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Gly Arg Asn 
    370                 375                 380                 


Pro Pro Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Gly Ser 
385                 390                 395                 400 


Ala Ser Gly Gln Gly Gly Tyr Gly Gly Leu Gly Gln Gly Gly Tyr Gly 
                405                 410                 415     


Gln Gly Ala Gly Ser Ser Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala 
            420                 425                 430         


Ala Ala Gly Gly Gln Gly Gly Gln Gly Gln Gly Gly Tyr Gly Gln Gly 
        435                 440                 445             


Ser Gly Gly Ser Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala 
    450                 455                 460                 


Ala Ala Ala Gly Arg Gly Gln Gly Gly Tyr Gly Gln Gly Ser Gly Gly 
465                 470                 475                 480 


Asn Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala 
                485                 490                 495     


Gly Gln Gly Gly Gln Gly Gly Tyr Gly Arg Gln Ser Gln Gly Ala Gly 
            500                 505                 510         


Ser Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Gly 
        515                 520                 525             


Ser Gly Gln Gly Gly Tyr Gly Gly Gln Gly Gln Gly Gly Tyr Gly Gln 
    530                 535                 540                 


Ser Ser Ala Ser Ala Ser Ala Ala Ala Ser Ala Ala Ser Thr Val Ala 
545                 550                 555                 560 


Asn Ser Val Ser Arg Leu Ser Ser Pro Ser Ala Val Ser Arg Val Ser 
                565                 570                 575     


Ser Ala Val Ser Ser Leu Val Ser Asn Gly Gln Val Asn Met Ala Ala 
            580                 585                 590         


Leu Pro Asn Ile Ile Ser Asn Ile Ser Ser Ser Val Ser Ala Ser Ala 
        595                 600                 605             


Pro Gly Ala Ser Gly Cys Glu Val Ile Val Gln Ala Leu Leu Glu Val 
    610                 615                 620                 


Ile Thr Ala Leu Val Gln Ile Val Ser Ser Ser Ser Val Gly Tyr Ile 
625                 630                 635                 640 


Asn Pro Ser Ala Val Asn Gln Ile Thr Asn Val Val Ala Asn Ala Met 
                645                 650                 655     


Ala Gln Val Met Gly 
            660     


<210>  106
<211>  588
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein

<400>  106

Met Gly Ser Ser Gly His His His His His His Met Gly Gly Gly Gly 
1               5                   10                  15      


Ser Val Asp Asn Lys Phe Asn Lys Glu Gln Gln Asn Ala Phe Tyr Glu 
            20                  25                  30          


Ile Leu His Leu Pro Asn Leu Asn Glu Glu Gln Arg Asn Ala Phe Ile 
        35                  40                  45              


Gln Ser Leu Lys Asp Asp Pro Ser Gln Ser Ala Asn Leu Leu Ala Glu 
    50                  55                  60                  


Ala Lys Lys Leu Asn Asp Ala Gln Ala Pro Lys Leu Glu Ala Leu Phe 
65                  70                  75                  80  


Gln Gly Pro Asn Ser Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu 
                85                  90                  95      


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
            100                 105                 110         


Thr Phe Ser Ser Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
        115                 120                 125             


Gly Leu Glu Trp Val Ser Gly Ile Gly Ser Tyr Gly Gly Gly Thr Tyr 
    130                 135                 140                 


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser 
145                 150                 155                 160 


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
                165                 170                 175     


Ala Val Tyr Tyr Cys Ala Arg Tyr Val Asn Phe Gly Met Asp Tyr Trp 
            180                 185                 190         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        195                 200                 205             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser 
    210                 215                 220                 


Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 
225                 230                 235                 240 


Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln Lys 
                245                 250                 255     


Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln 
            260                 265                 270         


Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
        275                 280                 285             


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr 
    290                 295                 300                 


Cys Gln Gln Tyr Gly Arg Asn Pro Pro Thr Phe Gly Gln Gly Thr Lys 
305                 310                 315                 320 


Leu Glu Ile Lys Arg Gly Ser Ala Ser Gly Gln Gly Gly Tyr Gly Gly 
                325                 330                 335     


Leu Gly Gln Gly Gly Tyr Gly Gln Gly Ala Gly Ser Ser Ala Ala Ala 
            340                 345                 350         


Ala Ala Ala Ala Ala Ala Ala Ala Ala Gly Gly Gln Gly Gly Gln Gly 
        355                 360                 365             


Gln Gly Gly Tyr Gly Gln Gly Ser Gly Gly Ser Ala Ala Ala Ala Ala 
    370                 375                 380                 


Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Gly Arg Gly Gln Gly Gly 
385                 390                 395                 400 


Tyr Gly Gln Gly Ser Gly Gly Asn Ala Ala Ala Ala Ala Ala Ala Ala 
                405                 410                 415     


Ala Ala Ala Ala Ala Ala Ala Gly Gln Gly Gly Gln Gly Gly Tyr Gly 
            420                 425                 430         


Arg Gln Ser Gln Gly Ala Gly Ser Ala Ala Ala Ala Ala Ala Ala Ala 
        435                 440                 445             


Ala Ala Ala Ala Ala Ala Gly Ser Gly Gln Gly Gly Tyr Gly Gly Gln 
    450                 455                 460                 


Gly Gln Gly Gly Tyr Gly Gln Ser Ser Ala Ser Ala Ser Ala Ala Ala 
465                 470                 475                 480 


Ser Ala Ala Ser Thr Val Ala Asn Ser Val Ser Arg Leu Ser Ser Pro 
                485                 490                 495     


Ser Ala Val Ser Arg Val Ser Ser Ala Val Ser Ser Leu Val Ser Asn 
            500                 505                 510         


Gly Gln Val Asn Met Ala Ala Leu Pro Asn Ile Ile Ser Asn Ile Ser 
        515                 520                 525             


Ser Ser Val Ser Ala Ser Ala Pro Gly Ala Ser Gly Cys Glu Val Ile 
    530                 535                 540                 


Val Gln Ala Leu Leu Glu Val Ile Thr Ala Leu Val Gln Ile Val Ser 
545                 550                 555                 560 


Ser Ser Ser Val Gly Tyr Ile Asn Pro Ser Ala Val Asn Gln Ile Thr 
                565                 570                 575     


Asn Val Val Ala Asn Ala Met Ala Gln Val Met Gly 
            580                 585             


<210>  107
<211>  414
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein

<400>  107

Met Gly Ser Ser Gly His His His His His His Met Gly Gly Gly Gly 
1               5                   10                  15      


Ser Ser His Thr Thr Pro Trp Thr Asn Pro Gly Leu Ala Glu Asn Phe 
            20                  25                  30          


Met Asn Ser Phe Met Gln Gly Leu Ser Ser Met Pro Gly Phe Thr Ala 
        35                  40                  45              


Ser Gln Leu Asp Lys Met Ser Thr Ile Ala Gln Ser Met Val Gln Ser 
    50                  55                  60                  


Ile Gln Ser Leu Ala Ala Gln Gly Arg Thr Ser Pro Asn Asp Leu Gln 
65                  70                  75                  80  


Ala Leu Asn Met Ala Phe Ala Ser Ser Met Ala Glu Ile Ala Ala Ser 
                85                  90                  95      


Glu Glu Gly Gly Gly Ser Leu Ser Thr Lys Thr Ser Ser Ile Ala Ser 
            100                 105                 110         


Ala Met Ser Asn Ala Phe Leu Gln Thr Thr Gly Val Val Asn Gln Pro 
        115                 120                 125             


Phe Ile Asn Glu Ile Thr Gln Leu Val Ser Met Phe Ala Gln Ala Gly 
    130                 135                 140                 


Met Asn Asp Val Leu Glu Ala Leu Phe Gln Gly Pro Asn Ser Glu Val 
145                 150                 155                 160 


Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
                165                 170                 175     


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met 
            180                 185                 190         


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Gly 
        195                 200                 205             


Ile Gly Ser Tyr Gly Gly Gly Thr Tyr Tyr Ala Asp Ser Val Lys Gly 
    210                 215                 220                 


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
225                 230                 235                 240 


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
                245                 250                 255     


Tyr Val Asn Phe Gly Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            260                 265                 270         


Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             


Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser 
    290                 295                 300                 


Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser 
305                 310                 315                 320 


Ser Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu 
                325                 330                 335     


Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe 
            340                 345                 350         


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu 
        355                 360                 365             


Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Gly Arg Asn 
    370                 375                 380                 


Pro Pro Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Gly Ser 
385                 390                 395                 400 


Ala Ser Gly Ser Gly Ser Gly Ser Leu Pro Glu Thr Gly Gly 
                405                 410                 


<210>  108
<211>  341
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein

<400>  108

Met Gly Ser Ser Gly His His His His His His Met Gly Gly Gly Gly 
1               5                   10                  15      


Ser Val Asp Asn Lys Phe Asn Lys Glu Gln Gln Asn Ala Phe Tyr Glu 
            20                  25                  30          


Ile Leu His Leu Pro Asn Leu Asn Glu Glu Gln Arg Asn Ala Phe Ile 
        35                  40                  45              


Gln Ser Leu Lys Asp Asp Pro Ser Gln Ser Ala Asn Leu Leu Ala Glu 
    50                  55                  60                  


Ala Lys Lys Leu Asn Asp Ala Gln Ala Pro Lys Leu Glu Ala Leu Phe 
65                  70                  75                  80  


Gln Gly Pro Asn Ser Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu 
                85                  90                  95      


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
            100                 105                 110         


Thr Phe Ser Ser Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
        115                 120                 125             


Gly Leu Glu Trp Val Ser Gly Ile Gly Ser Tyr Gly Gly Gly Thr Tyr 
    130                 135                 140                 


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser 
145                 150                 155                 160 


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
                165                 170                 175     


Ala Val Tyr Tyr Cys Ala Arg Tyr Val Asn Phe Gly Met Asp Tyr Trp 
            180                 185                 190         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        195                 200                 205             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser 
    210                 215                 220                 


Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 
225                 230                 235                 240 


Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln Lys 
                245                 250                 255     


Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln 
            260                 265                 270         


Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
        275                 280                 285             


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr 
    290                 295                 300                 


Cys Gln Gln Tyr Gly Arg Asn Pro Pro Thr Phe Gly Gln Gly Thr Lys 
305                 310                 315                 320 


Leu Glu Ile Lys Arg Gly Ser Ala Ser Gly Ser Gly Ser Gly Ser Leu 
                325                 330                 335     


Pro Glu Thr Gly Gly 
            340     


