                         SEQUENCE LISTING

<110>  Fraunhofer-Gesellschaft zur Frderung der angewandten 
       Forschung e.V.
       Rheinisch-Westflische Technische Hochschule Aachen
 
<120>  IMMUNOASSEMBLIN (IA) PROTEIN COMPLEXES

<130>  FRA-PA18-PCT/PCT

<150>  PCT/EP2015/076194
<151>  2015-11-10

<160>  107   

<170>  PatentIn version 3.5

<210>  1
<211>  95
<212>  PRT
<213>  Plasmodium falciparum

<400>  1

Ile Ser Gln His Gln Cys Val Lys Lys Gln Cys Pro Glu Asn Ser Gly 
1               5                   10                  15      


Cys Phe Arg His Leu Asp Glu Arg Glu Glu Cys Lys Cys Leu Leu Asn 
            20                  25                  30          


Tyr Lys Gln Glu Gly Asp Lys Cys Val Glu Asn Pro Asn Pro Thr Cys 
        35                  40                  45              


Asn Glu Asn Asn Gly Gly Cys Asp Ala Asp Ala Thr Cys Thr Glu Glu 
    50                  55                  60                  


Asp Ser Gly Ser Ser Arg Lys Lys Ile Thr Cys Glu Cys Thr Lys Pro 
65                  70                  75                  80  


Asp Ser Tyr Pro Leu Phe Asp Gly Ile Phe Cys Ser Ser Ser Asn 
                85                  90                  95  


<210>  2
<211>  95
<212>  PRT
<213>  Plasmodium falciparum

<400>  2

Ile Ser Gln His Gln Cys Val Lys Lys Gln Cys Pro Glu Asn Ser Gly 
1               5                   10                  15      


Cys Phe Arg His Leu Asp Glu Arg Glu Glu Cys Lys Cys Leu Leu Asn 
            20                  25                  30          


Tyr Lys Gln Glu Gly Asp Lys Cys Val Glu Asn Pro Asn Pro Thr Cys 
        35                  40                  45              


Asn Glu Asn Asn Gly Gly Cys Asp Ala Asp Ala Lys Cys Thr Glu Glu 
    50                  55                  60                  


Asp Ser Gly Ser Asn Gly Lys Lys Ile Thr Cys Glu Cys Thr Lys Pro 
65                  70                  75                  80  


Asp Ser Tyr Pro Leu Phe Asp Gly Ile Phe Cys Ser Ser Ser Asn 
                85                  90                  95  


<210>  3
<211>  94
<212>  PRT
<213>  Plasmodium falciparum

<400>  3

Ile Ser Gln His Gln Cys Val Lys Lys Gln Cys Pro Gln Asn Ser Gly 
1               5                   10                  15      


Cys Phe Arg His Leu Asp Glu Arg Glu Glu Cys Lys Cys Leu Leu Asn 
            20                  25                  30          


Tyr Lys Gln Glu Gly Asp Lys Cys Val Glu Asn Pro Asn Pro Thr Cys 
        35                  40                  45              


Asn Glu Asn Asn Gly Gly Cys Asp Ala Asp Ala Lys Cys Thr Glu Glu 
    50                  55                  60                  


Asp Ser Gly Ser Asn Gly Lys Lys Ile Thr Cys Glu Cys Thr Lys Pro 
65                  70                  75                  80  


Asp Ser Tyr Pro Leu Phe Asp Gly Ile Phe Cys Ser Ser Ser 
                85                  90                  


<210>  4
<211>  95
<212>  PRT
<213>  Plasmodium falciparum

<400>  4

Ile Ser Gln His Gln Cys Val Lys Lys Gln Cys Pro Gln Asn Ser Gly 
1               5                   10                  15      


Cys Phe Arg His Leu Asp Glu Arg Glu Glu Cys Lys Cys Leu Leu Asn 
            20                  25                  30          


Tyr Lys Gln Glu Gly Asp Lys Cys Val Glu Asn Pro Asn Pro Thr Cys 
        35                  40                  45              


Asn Glu Asn Asn Gly Gly Cys Asp Ala Asp Ala Lys Cys Thr Glu Glu 
    50                  55                  60                  


Asp Ser Gly Ser Asn Gly Lys Lys Ile Thr Cys Glu Cys Thr Lys Pro 
65                  70                  75                  80  


Asp Ser Tyr Pro Phe Phe Asp Gly Ile Phe Cys Ser Ser Ser Asn 
                85                  90                  95  


<210>  5
<211>  398
<212>  PRT
<213>  Plasmodium falciparum

<400>  5

Ile Ser Gln His Gln Cys Val Lys Lys Gln Cys Pro Glu Asn Ser Gly 
1               5                   10                  15      


Cys Phe Arg His Leu Asp Glu Arg Glu Glu Cys Lys Cys Leu Leu Asn 
            20                  25                  30          


Tyr Lys Gln Glu Gly Asp Lys Cys Val Glu Asn Pro Asn Pro Thr Cys 
        35                  40                  45              


Asn Glu Asn Asn Gly Gly Cys Asp Ala Asp Ala Thr Cys Thr Glu Glu 
    50                  55                  60                  


Asp Ser Gly Ser Ser Arg Lys Lys Ile Thr Cys Glu Cys Thr Lys Pro 
65                  70                  75                  80  


Asp Ser Tyr Pro Leu Phe Asp Gly Ile Phe Cys Ser Ser Ser Asn Ala 
                85                  90                  95      


Ala Val Ala Met Ala Ile Ser Gln His Gln Cys Val Lys Lys Gln Cys 
            100                 105                 110         


Pro Glu Asn Ser Gly Cys Phe Arg His Leu Asp Glu Arg Glu Glu Cys 
        115                 120                 125             


Lys Cys Leu Leu Asn Tyr Lys Gln Glu Gly Asp Lys Cys Val Glu Asn 
    130                 135                 140                 


Pro Asn Pro Thr Cys Asn Glu Asn Asn Gly Gly Cys Asp Ala Asp Ala 
145                 150                 155                 160 


Lys Cys Thr Glu Glu Asp Ser Gly Ser Asn Gly Lys Lys Ile Thr Cys 
                165                 170                 175     


Glu Cys Thr Lys Pro Asp Ser Tyr Pro Leu Phe Asp Gly Ile Phe Cys 
            180                 185                 190         


Ser Ser Ser Asn Ala Ala Val Ala Met Ala Ile Ser Gln His Gln Cys 
        195                 200                 205             


Val Lys Lys Gln Cys Pro Gln Asn Ser Gly Cys Phe Arg His Leu Asp 
    210                 215                 220                 


Glu Arg Glu Glu Cys Lys Cys Leu Leu Asn Tyr Lys Gln Glu Gly Asp 
225                 230                 235                 240 


Lys Cys Val Glu Asn Pro Asn Pro Thr Cys Asn Glu Asn Asn Gly Gly 
                245                 250                 255     


Cys Asp Ala Asp Ala Lys Cys Thr Glu Glu Asp Ser Gly Ser Asn Gly 
            260                 265                 270         


Lys Lys Ile Thr Cys Glu Cys Thr Lys Pro Asp Ser Tyr Pro Leu Phe 
        275                 280                 285             


Asp Gly Ile Phe Cys Ser Ser Ser Asn Ala Ala Val Ala Met Ala Ile 
    290                 295                 300                 


Ser Gln His Gln Cys Val Lys Lys Gln Cys Pro Gln Asn Ser Gly Cys 
305                 310                 315                 320 


Phe Arg His Leu Asp Glu Arg Glu Glu Cys Lys Cys Leu Leu Asn Tyr 
                325                 330                 335     


Lys Gln Glu Gly Asp Lys Cys Val Glu Asn Pro Asn Pro Thr Cys Asn 
            340                 345                 350         


Glu Asn Asn Gly Gly Cys Asp Ala Asp Ala Lys Cys Thr Glu Glu Asp 
        355                 360                 365             


Ser Gly Ser Asn Gly Lys Lys Ile Thr Cys Glu Cys Thr Lys Pro Asp 
    370                 375                 380                 


Ser Tyr Pro Phe Phe Asp Gly Ile Phe Cys Ser Ser Ser Asn 
385                 390                 395             


<210>  6
<211>  169
<212>  PRT
<213>  Plasmodium falciparum

<400>  6

Val Thr Val Asp Thr Val Cys Lys Arg Gly Phe Leu Ile Gln Met Ser 
1               5                   10                  15      


Gly His Leu Glu Cys Lys Cys Glu Asn Asp Leu Val Leu Val Asn Glu 
            20                  25                  30          


Glu Thr Cys Glu Glu Lys Val Leu Lys Cys Asp Glu Lys Thr Val Asn 
        35                  40                  45              


Lys Pro Cys Gly Asp Phe Ser Lys Cys Ile Lys Ile Asp Gly Asn Pro 
    50                  55                  60                  


Val Ser Tyr Ala Cys Lys Cys Asn Leu Gly Tyr Asp Met Val Asn Asn 
65                  70                  75                  80  


Val Cys Ile Pro Asn Glu Cys Lys Asn Val Ala Cys Gly Asn Gly Lys 
                85                  90                  95      


Cys Ile Leu Asp Thr Ser Asn Pro Val Lys Thr Gly Val Cys Ser Cys 
            100                 105                 110         


Asn Ile Gly Lys Val Pro Asn Val Gln Asp Gln Lys Cys Ser Lys Asp 
        115                 120                 125             


Gly Glu Thr Lys Cys Ser Leu Lys Cys Leu Lys Glu Asn Glu Ala Cys 
    130                 135                 140                 


Lys Ala Val Asp Gly Ile Tyr Lys Cys Asp Cys Lys Asp Gly Phe Ile 
145                 150                 155                 160 


Ile Asp Asn Glu Ala Ser Ile Cys Thr 
                165                 


<210>  7
<211>  169
<212>  PRT
<213>  Plasmodium falciparum

<400>  7

Val Thr Val Asp Thr Val Cys Lys Arg Gly Phe Leu Ile Gln Met Ser 
1               5                   10                  15      


Gly His Leu Glu Cys Lys Cys Glu Asn Asp Thr Val Leu Val Asn Glu 
            20                  25                  30          


Glu Thr Cys Glu Glu Lys Val Leu Lys Cys Asp Glu Lys Thr Val Asn 
        35                  40                  45              


Lys Pro Cys Gly Asp Phe Ser Lys Cys Ile Lys Ile Asp Gly Asn Pro 
    50                  55                  60                  


Val Ser Tyr Ala Cys Lys Cys Asn Leu Gly Tyr Asp Met Val Asn Asn 
65                  70                  75                  80  


Val Cys Ile Pro Asn Glu Cys Lys Asn Val Thr Cys Gly Asn Gly Lys 
                85                  90                  95      


Cys Ile Leu Asp Thr Ser Asn Pro Val Lys Thr Gly Val Cys Ser Cys 
            100                 105                 110         


Asn Ile Gly Lys Val Pro Asn Val Gln Asp Gln Lys Cys Ser Lys Asp 
        115                 120                 125             


Gly Glu Thr Lys Cys Ser Leu Lys Cys Leu Lys Glu Asn Glu Thr Cys 
    130                 135                 140                 


Lys Ala Val Asp Gly Ile Tyr Lys Cys Asp Cys Lys Asp Gly Phe Ile 
145                 150                 155                 160 


Ile Asp Asn Glu Ala Ser Ile Cys Thr 
                165                 


<210>  8
<211>  168
<212>  PRT
<213>  Plasmodium falciparum

<400>  8

Val Thr Glu Asn Thr Ile Cys Lys Tyr Gly Tyr Leu Ile Gln Met Ser 
1               5                   10                  15      


Asn His Tyr Glu Cys Lys Cys Ile Glu Gly Tyr Val Leu Ile Asn Glu 
            20                  25                  30          


Asp Thr Cys Gly Lys Lys Val Val Cys Asp Lys Val Glu Asn Ser Phe 
        35                  40                  45              


Lys Ala Cys Asp Glu Tyr Ala Tyr Cys Phe Asp Leu Gly Asn Lys Asn 
    50                  55                  60                  


Asn Glu Lys Gln Ile Lys Cys Met Cys Arg Thr Glu Tyr Thr Leu Thr 
65                  70                  75                  80  


Ala Gly Val Cys Val Pro Asn Val Cys Arg Asp Lys Val Cys Gly Lys 
                85                  90                  95      


Gly Lys Cys Ile Val Asp Pro Ala Asn Ser Leu Thr His Thr Cys Ser 
            100                 105                 110         


Cys Asn Ile Gly Thr Ile Leu Asn Gln Asn Lys Leu Cys Asp Ile Gln 
        115                 120                 125             


Gly Asp Thr Pro Cys Ser Leu Lys Cys Ala Glu Asn Glu Val Cys Thr 
    130                 135                 140                 


Leu Glu Gly Asn Tyr Tyr Thr Cys Lys Glu Asp Pro Ser Ser Asn Gly 
145                 150                 155                 160 


Gly Gly Asn Thr Val Asp Gln Ala 
                165             


<210>  9
<211>  74
<212>  PRT
<213>  Plasmodium falciparum

<400>  9

Pro Ser Asp Lys His Ile Glu Gln Tyr Leu Lys Lys Ile Gln Asn Ser 
1               5                   10                  15      


Leu Ser Thr Glu Trp Ser Pro Cys Ser Val Thr Cys Gly Asn Gly Ile 
            20                  25                  30          


Gln Val Arg Ile Lys Pro Gly Ser Ala Asn Lys Pro Lys Asp Glu Leu 
        35                  40                  45              


Asp Tyr Glu Asn Asp Ile Glu Lys Lys Ile Cys Lys Met Glu Lys Cys 
    50                  55                  60                  


Ser Ser Val Phe Asn Val Val Asn Ser Ser 
65                  70                  


<210>  10
<211>  51
<212>  PRT
<213>  Plasmodium falciparum

<400>  10

Glu Lys Thr Ala Ser Cys Gly Val Trp Asp Glu Trp Ser Pro Cys Ser 
1               5                   10                  15      


Val Thr Cys Gly Lys Gly Thr Arg Ser Arg Lys Arg Glu Ile Leu His 
            20                  25                  30          


Glu Gly Cys Thr Ser Glu Leu Gln Glu Gln Cys Glu Glu Glu Arg Cys 
        35                  40                  45              


Leu Pro Lys 
    50      


<210>  11
<211>  74
<212>  PRT
<213>  Plasmodium falciparum

<400>  11

Thr His Asp Thr Cys Asp Glu Trp Ser Glu Trp Ser Ala Cys Thr His 
1               5                   10                  15      


Gly Ile Ser Thr Arg Lys Cys Leu Ser Asp Ser Ser Ile Lys Asp Glu 
            20                  25                  30          


Thr Leu Val Cys Thr Lys Cys Asp Lys Trp Gly Glu Trp Ser Glu Cys 
        35                  40                  45              


Lys Asp Gly Arg Met His Arg Lys Val Leu Asn Cys Pro Phe Ile Lys 
    50                  55                  60                  


Glu Glu Gln Glu Cys Asp Val Asn Asn Glu 
65                  70                  


<210>  12
<211>  65
<212>  PRT
<213>  Plasmodium falciparum

<400>  12

Phe Tyr Ser Glu Trp Gly Glu Trp Ser Asn Cys Ala Met Asp Cys Asp 
1               5                   10                  15      


His Pro Asp Asn Val Gln Ile Arg Glu Arg Glu Cys Ile His Pro Ser 
            20                  25                  30          


Gly Asp Cys Phe Lys Gly Asp Leu Lys Glu Ser Arg Pro Cys Ile Ile 
        35                  40                  45              


Pro Leu Pro Cys Asn Glu Leu Phe Ser His Lys Asp Asn Ser Ala Phe 
    50                  55                  60                  


Lys 
65  


<210>  13
<211>  283
<212>  PRT
<213>  Plasmodium falciparum

<400>  13

Pro Ser Asp Lys His Ile Glu Gln Tyr Leu Lys Lys Ile Gln Asn Ser 
1               5                   10                  15      


Leu Ser Thr Glu Trp Ser Pro Cys Ser Val Thr Cys Gly Asn Gly Ile 
            20                  25                  30          


Gln Val Arg Ile Lys Pro Gly Ser Ala Asn Lys Pro Lys Asp Glu Leu 
        35                  40                  45              


Asp Tyr Glu Asn Asp Ile Glu Lys Lys Ile Cys Lys Met Glu Lys Cys 
    50                  55                  60                  


Ser Ser Val Phe Asn Val Val Asn Ser Ser Ala Ala Val Ala Met Ala 
65                  70                  75                  80  


Glu Lys Thr Ala Ser Cys Gly Val Trp Asp Glu Trp Ser Pro Cys Ser 
                85                  90                  95      


Val Thr Cys Gly Lys Gly Thr Arg Ser Arg Lys Arg Glu Ile Leu His 
            100                 105                 110         


Glu Gly Cys Thr Ser Glu Leu Gln Glu Gln Cys Glu Glu Glu Arg Cys 
        115                 120                 125             


Leu Pro Lys Ala Ala Val Ala Met Ala Thr His Asp Thr Cys Asp Glu 
    130                 135                 140                 


Trp Ser Glu Trp Ser Ala Cys Thr His Gly Ile Ser Thr Arg Lys Cys 
145                 150                 155                 160 


Leu Ser Asp Ser Ser Ile Lys Asp Glu Thr Leu Val Cys Thr Lys Cys 
                165                 170                 175     


Asp Lys Trp Gly Glu Trp Ser Glu Cys Lys Asp Gly Arg Met His Arg 
            180                 185                 190         


Lys Val Leu Asn Cys Pro Phe Ile Lys Glu Glu Gln Glu Cys Asp Val 
        195                 200                 205             


Asn Asn Glu Ala Ala Val Ala Met Ala Phe Tyr Ser Glu Trp Gly Glu 
    210                 215                 220                 


Trp Ser Asn Cys Ala Met Asp Cys Asp His Pro Asp Asn Val Gln Ile 
225                 230                 235                 240 


Arg Glu Arg Glu Cys Ile His Pro Ser Gly Asp Cys Phe Lys Gly Asp 
                245                 250                 255     


Leu Lys Glu Ser Arg Pro Cys Ile Ile Pro Leu Pro Pro Cys Asn Glu 
            260                 265                 270         


Leu Phe Ser His Lys Asp Asn Ser Ala Phe Lys 
        275                 280             


<210>  14
<211>  63
<212>  PRT
<213>  Plasmodium falciparum

<400>  14

Glu Arg Val Ala Asn Cys Gly Pro Trp Asp Pro Trp Thr Ala Cys Ser 
1               5                   10                  15      


Val Thr Cys Gly Arg Gly Thr His Ser Arg Ser Arg Pro Ser Leu His 
            20                  25                  30          


Glu Lys Cys Thr Thr His Met Val Ser Glu Cys Glu Glu Gly Glu Cys 
        35                  40                  45              


Pro Val Glu Pro Glu Pro Leu Pro Val Pro Ala Pro Leu Pro Thr 
    50                  55                  60              


<210>  15
<211>  54
<212>  PRT
<213>  Plasmodium falciparum

<400>  15

Glu Val Glu Arg Ile Ala Lys Cys Gly Pro Trp Asp Asp Trp Thr Pro 
1               5                   10                  15      


Cys Ser Val Thr Cys Gly Lys Gly Thr His Ser Arg Ser Arg Pro Leu 
            20                  25                  30          


Leu His Ala Gly Cys Thr Thr His Met Val Lys Glu Cys Glu Met Asp 
        35                  40                  45              


Glu Cys Pro Val Glu Pro 
    50                  


<210>  16
<211>  201
<212>  PRT
<213>  Plasmodium falciparum

<400>  16

Glu Lys Thr Ala Ser Cys Gly Val Trp Asp Glu Trp Ser Pro Cys Ser 
1               5                   10                  15      


Val Thr Cys Gly Lys Gly Thr Arg Ser Arg Lys Arg Glu Ile Leu His 
            20                  25                  30          


Glu Gly Cys Thr Ser Glu Leu Gln Glu Gln Cys Glu Glu Glu Arg Cys 
        35                  40                  45              


Leu Pro Lys Ala Ala Val Ala Met Ala Glu Arg Val Ala Asn Cys Gly 
    50                  55                  60                  


Pro Trp Asp Pro Trp Thr Ala Cys Ser Val Thr Cys Gly Arg Gly Thr 
65                  70                  75                  80  


His Ser Arg Ser Arg Pro Ser Leu His Glu Lys Cys Thr Thr His Met 
                85                  90                  95      


Val Ser Glu Cys Glu Glu Gly Glu Cys Pro Val Glu Pro Glu Pro Leu 
            100                 105                 110         


Pro Val Pro Ala Pro Leu Pro Thr Ala Ala Val Ala Met Ala Glu Val 
        115                 120                 125             


Glu Arg Ile Ala Lys Cys Gly Pro Thr Ala Ala Thr Cys Gly Gly Cys 
    130                 135                 140                 


Cys Gly Thr Gly Gly Cys Cys Ala Thr Gly Gly Cys Thr Trp Asp Asp 
145                 150                 155                 160 


Trp Thr Pro Cys Ser Val Thr Cys Gly Lys Gly Thr His Ser Arg Ser 
                165                 170                 175     


Arg Pro Leu Leu His Ala Gly Cys Thr Thr His Met Val Lys Glu Cys 
            180                 185                 190         


Glu Met Asp Glu Cys Pro Val Glu Pro 
        195                 200     


<210>  17
<211>  329
<212>  PRT
<213>  Plasmodium falciparum

<400>  17

Ser Lys Glu Ile Val Lys Lys Tyr Asn Leu Asn Leu Arg Asn Ala Ile 
1               5                   10                  15      


Leu Asn Asn Asn Ser Gln Ile Glu Asn Glu Glu Asn Val Asn Thr Thr 
            20                  25                  30          


Ile Thr Gly Asn Asp Phe Ser Gly Gly Glu Phe Leu Trp Pro Gly Tyr 
        35                  40                  45              


Thr Glu Glu Leu Lys Ala Lys Lys Ala Ser Glu Asp Ala Glu Lys Ala 
    50                  55                  60                  


Ala Asn Asp Ala Glu Asn Ala Ser Lys Glu Ala Glu Glu Ala Ala Lys 
65                  70                  75                  80  


Glu Ala Val Asn Leu Lys Glu Ser Asp Lys Ser Tyr Thr Lys Ala Lys 
                85                  90                  95      


Glu Ala Ala Thr Ala Ala Ser Lys Ala Lys Lys Ala Val Glu Thr Ala 
            100                 105                 110         


Leu Lys Ala Lys Asp Asp Ala Glu Lys Ser Ser Lys Ala Asp Ser Ile 
        115                 120                 125             


Ser Thr Lys Thr Lys Glu Tyr Ala Glu Lys Ala Lys Asn Ala Tyr Glu 
    130                 135                 140                 


Lys Ala Lys Asn Ala Tyr Gln Lys Ala Asn Gln Ala Val Leu Lys Ala 
145                 150                 155                 160 


Lys Glu Ala Ser Ser Tyr Asp Tyr Ile Leu Gly Trp Glu Phe Gly Gly 
                165                 170                 175     


Gly Val Pro Glu His Lys Lys Glu Glu Asn Met Leu Ser His Leu Tyr 
            180                 185                 190         


Val Ser Ser Lys Asp Lys Glu Asn Ile Ala Lys Glu Asn Asp Asp Val 
        195                 200                 205             


Leu Asp Glu Lys Glu Glu Glu Ala Glu Glu Thr Glu Glu Glu Glu Leu 
    210                 215                 220                 


Glu Glu Lys Asn Glu Glu Glu Thr Glu Ser Glu Ile Ser Glu Asp Glu 
225                 230                 235                 240 


Glu Glu Glu Glu Glu Glu Glu Lys Glu Glu Glu Asn Asp Lys Lys Lys 
                245                 250                 255     


Glu Gln Glu Lys Glu Gln Ser Asn Glu Asn Asn Asp Gln Lys Lys Asp 
            260                 265                 270         


Met Glu Ala Gln Asn Leu Ile Ser Lys Asn Gln Asn Asn Asn Glu Lys 
        275                 280                 285             


Asn Val Lys Glu Ala Ala Glu Ser Ile Met Lys Thr Leu Ala Gly Leu 
    290                 295                 300                 


Ile Lys Gly Asn Asn Gln Ile Asp Ser Thr Leu Lys Asp Leu Val Glu 
305                 310                 315                 320 


Glu Leu Ser Lys Tyr Phe Lys Asn His 
                325                 


<210>  18
<211>  355
<212>  PRT
<213>  Plasmodium falciparum

<400>  18

Ser Lys Glu Ile Val Lys Lys Tyr Asn Leu Asn Leu Arg Asn Ala Ile 
1               5                   10                  15      


Leu Asn Asn Asn Ser Gln Ile Glu Asn Glu Glu Asn Asp Ile Lys Tyr 
            20                  25                  30          


Glu Leu Asn Glu Gln Asn Asp Glu Asn Val Asn Thr Pro Ile Val Gly 
        35                  40                  45              


Asn Met Glu Phe Gly Glu Gly Phe Ser Ala Asp Asp Gln Lys Asp Ile 
    50                  55                  60                  


Glu Ala Tyr Lys Lys Ala Lys Gln Ala Ser Gln Asp Ala Glu Gln Ala 
65                  70                  75                  80  


Ala Lys Asp Ala Glu Asn Ala Ala Lys Asp Ala Glu Glu Ala Ala Lys 
                85                  90                  95      


Asp Ala Glu Lys Leu Lys Glu Ser Asp Glu Ser Tyr Thr Lys Ala Lys 
            100                 105                 110         


Glu Ala Cys Thr Ala Ala Ser Lys Ala Lys Lys Ala Val Glu Thr Ala 
        115                 120                 125             


Leu Lys Ala Lys Asp Asp Ala Glu Thr Ala Leu Lys Thr Ser Glu Thr 
    130                 135                 140                 


Pro Glu Lys Pro Ser Arg Ile Asn Leu Phe Ser Arg Lys Thr Lys Glu 
145                 150                 155                 160 


Tyr Ala Glu Lys Ala Lys Asn Ala Tyr Glu Lys Ala Lys Asn Ala Tyr 
                165                 170                 175     


Gln Lys Ala Asn Gln Ala Val Leu Lys Ala Lys Glu Ala Ser Ser Tyr 
            180                 185                 190         


Asp Tyr Ile Leu Gly Trp Glu Phe Gly Gly Gly Val Pro Glu His Lys 
        195                 200                 205             


Lys Glu Glu Asn Met Leu Ser His Leu Tyr Val Ser Ser Lys Asp Lys 
    210                 215                 220                 


Glu Asn Ile Ala Lys Glu Asn Asp Asp Val Leu Asp Glu Lys Glu Glu 
225                 230                 235                 240 


Glu Ala Glu Glu Thr Glu Glu Glu Glu Leu Glu Glu Lys Asn Glu Glu 
                245                 250                 255     


Glu Thr Glu Ser Glu Ile Ser Glu Asp Glu Glu Glu Glu Glu Glu Glu 
            260                 265                 270         


Glu Lys Glu Glu Glu Asn Asp Lys Lys Lys Glu Gln Glu Lys Glu Gln 
        275                 280                 285             


Ser Asn Glu Asn Asn Asp Gln Lys Lys Asp Met Glu Ala Gln Asn Leu 
    290                 295                 300                 


Ile Ser Lys Asn Gln Asn Asn Asn Glu Lys Asn Val Lys Glu Ala Ala 
305                 310                 315                 320 


Glu Ser Ile Met Lys Thr Leu Ala Gly Leu Ile Lys Gly Asn Asn Gln 
                325                 330                 335     


Ile Asp Ser Thr Leu Lys Asp Leu Val Glu Glu Leu Ser Lys Tyr Phe 
            340                 345                 350         


Lys Asn His 
        355 


<210>  19
<211>  226
<212>  PRT
<213>  Plasmodium falciparum

<400>  19

Asn Gly Leu Thr Gly Ala Thr Glu Asn Ile Ala Gln Val Val Gln Ala 
1               5                   10                  15      


Asn Ser Glu Thr Asn Lys Asn Pro Thr Ser His Ser Asn Ser Thr Thr 
            20                  25                  30          


Thr Ser Leu Asn Asn Asn Ile Leu Gly Trp Glu Phe Gly Gly Gly Ala 
        35                  40                  45              


Pro Gln Asn Gly Ala Ala Glu Asp Lys Lys Thr Glu Tyr Leu Leu Glu 
    50                  55                  60                  


Gln Ile Lys Ile Pro Ser Trp Asp Arg Asn Asn Ile Pro Asp Glu Asn 
65                  70                  75                  80  


Glu Gln Val Ile Glu Asp Pro Gln Glu Asp Asn Lys Asp Glu Asp Glu 
                85                  90                  95      


Asp Glu Glu Thr Glu Thr Glu Asn Leu Glu Thr Glu Asp Asp Asn Asn 
            100                 105                 110         


Glu Glu Ile Glu Glu Asn Glu Glu Asp Asp Ile Asp Glu Glu Ser Val 
        115                 120                 125             


Glu Glu Lys Glu Glu Glu Glu Glu Lys Lys Glu Glu Glu Glu Lys Lys 
    130                 135                 140                 


Glu Glu Lys Lys Glu Glu Lys Lys Pro Asp Asn Glu Ile Thr Asn Glu 
145                 150                 155                 160 


Val Lys Glu Glu Gln Lys Tyr Ser Ser Pro Ser Asp Ile Asn Ala Gln 
                165                 170                 175     


Asn Leu Ile Ser Asn Lys Asn Lys Lys Asn Asp Glu Thr Lys Lys Thr 
            180                 185                 190         


Ala Glu Asn Ile Val Lys Thr Leu Val Gly Leu Phe Asn Glu Lys Asn 
        195                 200                 205             


Glu Ile Asp Ser Thr Ile Asn Asn Leu Val Gln Glu Met Ile His Leu 
    210                 215                 220                 


Phe Ser 
225     


<210>  20
<211>  174
<212>  PRT
<213>  Plasmodium falciparum

<400>  20

Ser Glu Thr Asp Thr Gln Ser Lys Asn Glu Gln Glu Ile Ser Thr Gln 
1               5                   10                  15      


Gly Gln Glu Val Gln Lys Pro Ala Gln Gly Gly Glu Ser Thr Phe Gln 
            20                  25                  30          


Lys Asp Leu Asp Lys Lys Leu Tyr Asn Leu Gly Asp Val Phe Asn His 
        35                  40                  45              


Val Val Asp Ile Ser Asn Lys Glu Asn Lys Ile Asn Leu Asp Glu His 
    50                  55                  60                  


Asp Lys Lys Tyr Thr Asp Phe Lys Lys Glu Tyr Glu Asp Phe Val Leu 
65                  70                  75                  80  


Asn Ser Lys Glu Tyr Asp Ile Ile Lys Asn Leu Ile Ile Met Phe Gly 
                85                  90                  95      


Gln Glu Asp Asn Lys Ala Lys Asn Gly Lys Thr Asp Ile Val Ser Glu 
            100                 105                 110         


Ala Lys His Ile Thr Glu Ile Phe Ile Lys Leu Phe Lys Asp Lys Glu 
        115                 120                 125             


Tyr His Glu Gln Phe Lys Asn Tyr Ile Tyr Gly Val Tyr Ser Tyr Ala 
    130                 135                 140                 


Lys Gln Asn Ser His Leu Ser Glu Lys Lys Ile Lys Gln Glu Glu Glu 
145                 150                 155                 160 


Tyr Lys Lys Phe Leu Glu Tyr Ser Phe Asn Leu Leu Asn Thr 
                165                 170                 


<210>  21
<211>  118
<212>  PRT
<213>  Plasmodium falciparum

<400>  21

Glu Lys Thr Asn Lys Gly Thr Gly Ser Gly Val Ser Ser Lys Lys Lys 
1               5                   10                  15      


Asn Lys Lys Gly Ser Gly Glu Pro Leu Ile Asp Val His Asp Leu Ile 
            20                  25                  30          


Ser Asp Met Ile Lys Lys Glu Glu Glu Leu Val Glu Val Asn Lys Arg 
        35                  40                  45              


Lys Ser Lys Tyr Lys Leu Ala Thr Ser Asn Thr Glu Lys Gly Arg His 
    50                  55                  60                  


Pro Phe Lys Ile Gly Ser Ser Asp Pro Ala Asp Asn Ala Asn Pro Asp 
65                  70                  75                  80  


Ala Asp Ser Glu Ser Asn Gly Glu Pro Asn Ala Asp Pro Gln Val Thr 
                85                  90                  95      


Ala Gln Asp Val Thr Pro Glu Gln Pro Gln Gly Asp Asp Asn Asn Leu 
            100                 105                 110         


Val Ser Gly Pro Glu His 
        115             


<210>  22
<211>  283
<212>  PRT
<213>  Plasmodium falciparum

<400>  22

Asp Lys Asn Ser Val Asp Thr Asn Thr Lys Val Trp Glu Cys Lys Lys 
1               5                   10                  15      


Pro Tyr Lys Leu Ser Thr Lys Asp Val Cys Val Pro Pro Arg Arg Gln 
            20                  25                  30          


Glu Leu Cys Leu Gly Asn Ile Asp Arg Ile Tyr Asp Lys Asn Leu Leu 
        35                  40                  45              


Met Ile Lys Glu His Ile Leu Ala Ile Ala Ile Tyr Glu Ser Arg Ile 
    50                  55                  60                  


Leu Lys Arg Lys Tyr Lys Asn Lys Asp Asp Lys Glu Val Cys Lys Ile 
65                  70                  75                  80  


Ile Asn Lys Ala Phe Ala Asp Ile Arg Asp Ile Ile Gly Gly Thr Asp 
                85                  90                  95      


Tyr Trp Asn Asp Leu Ser Asn Arg Lys Leu Val Gly Lys Ile Asn Thr 
            100                 105                 110         


Asn Ser Asn Tyr Val His Arg Asn Lys Gln Asn Asp Lys Leu Phe Arg 
        115                 120                 125             


Asp Glu Trp Trp Lys Val Ile Lys Lys Asp Val Trp Asn Val Ile Ser 
    130                 135                 140                 


Trp Val Phe Lys Asp Lys Thr Val Cys Lys Glu Asp Asp Ile Glu Asn 
145                 150                 155                 160 


Ile Pro Gln Phe Phe Arg Trp Phe Ser Glu Trp Gly Asp Asp Tyr Cys 
                165                 170                 175     


Gln Asp Lys Thr Lys Met Ile Glu Thr Leu Lys Val Glu Cys Lys Glu 
            180                 185                 190         


Lys Pro Cys Glu Asp Asp Asn Cys Lys Arg Lys Cys Asn Ser Tyr Lys 
        195                 200                 205             


Glu Trp Ile Ser Lys Lys Lys Glu Glu Tyr Asn Lys Gln Ala Lys Gln 
    210                 215                 220                 


Tyr Gln Glu Tyr Gln Lys Gly Asn Asn Tyr Lys Met Tyr Ser Glu Phe 
225                 230                 235                 240 


Lys Ser Ile Lys Pro Glu Val Tyr Leu Lys Lys Tyr Ser Glu Lys Cys 
                245                 250                 255     


Ser Asn Leu Asn Phe Glu Asp Glu Phe Lys Glu Glu Leu His Ser Asp 
            260                 265                 270         


Tyr Lys Asn Lys Cys Thr Met Cys Pro Glu Val 
        275                 280             


<210>  23
<211>  450
<212>  PRT
<213>  Plasmodium falciparum

<400>  23

Ile Glu Ile Val Glu Arg Ser Asn Tyr Met Gly Asn Pro Trp Thr Glu 
1               5                   10                  15      


Tyr Met Ala Lys Tyr Asp Ile Glu Glu Val His Gly Ser Gly Ile Arg 
            20                  25                  30          


Val Asp Leu Gly Glu Asp Ala Glu Val Ala Gly Thr Gln Tyr Arg Leu 
        35                  40                  45              


Pro Ser Gly Lys Cys Pro Val Phe Gly Lys Gly Ile Ile Ile Glu Asn 
    50                  55                  60                  


Ser Asn Thr Ala Phe Leu Thr Pro Val Ala Thr Gly Asn Gln Tyr Leu 
65                  70                  75                  80  


Lys Asp Gly Gly Phe Ala Phe Pro Pro Thr Glu Pro Leu Met Ser Pro 
                85                  90                  95      


Met Thr Leu Asp Glu Met Arg His Phe Tyr Lys Asp Asn Lys Tyr Val 
            100                 105                 110         


Lys Asn Leu Asp Glu Leu Thr Leu Cys Ser Arg His Ala Gly Asn Met 
        115                 120                 125             


Ile Pro Asp Asn Asp Lys Asn Ser Asn Tyr Lys Tyr Pro Ala Val Tyr 
    130                 135                 140                 


Asp Asp Lys Asp Lys Lys Cys His Ile Leu Tyr Ile Ala Ala Gln Glu 
145                 150                 155                 160 


Asn Asn Gly Pro Arg Tyr Cys Asn Lys Asp Glu Ser Lys Arg Asn Ser 
                165                 170                 175     


Met Phe Cys Phe Arg Pro Ala Lys Asp Ile Ser Phe Gln Asn Tyr Ala 
            180                 185                 190         


Tyr Leu Ser Lys Asn Val Val Asp Asn Trp Glu Lys Val Cys Pro Arg 
        195                 200                 205             


Lys Asn Leu Gln Asn Ala Lys Phe Gly Leu Trp Val Asp Gly Asn Cys 
    210                 215                 220                 


Glu Asp Ile Pro His Val Asn Glu Phe Pro Ala Ile Asp Leu Phe Glu 
225                 230                 235                 240 


Cys Asn Lys Leu Val Phe Glu Leu Ser Ala Ser Asp Gln Pro Lys Gln 
                245                 250                 255     


Tyr Glu Gln His Leu Thr Asp Tyr Glu Lys Ile Lys Glu Gly Phe Lys 
            260                 265                 270         


Asn Lys Asn Ala Ala Met Ile Lys Ser Ala Phe Leu Pro Thr Gly Ala 
        275                 280                 285             


Phe Lys Ala Asp Arg Tyr Lys Ser His Gly Lys Gly Tyr Asn Trp Gly 
    290                 295                 300                 


Asn Tyr Asn Thr Glu Thr Gln Lys Cys Glu Ile Phe Asn Val Lys Pro 
305                 310                 315                 320 


Thr Cys Leu Ile Asn Asn Ala Ala Tyr Ile Ala Thr Thr Ala Leu Ser 
                325                 330                 335     


His Pro Ile Glu Val Glu Asn Asn Phe Pro Cys Ser Leu Tyr Lys Asp 
            340                 345                 350         


Glu Ile Met Lys Glu Ile Glu Arg Glu Ser Lys Arg Ile Lys Leu Asn 
        355                 360                 365             


Asp Asn Asp Asp Glu Gly Asn Lys Lys Ile Ile Ala Pro Arg Ile Phe 
    370                 375                 380                 


Ile Ser Asp Asp Lys Asp Ser Leu Lys Cys Pro Cys Asp Pro Glu Met 
385                 390                 395                 400 


Val Ser Asn Ser Ala Cys Arg Phe Phe Val Cys Lys Cys Val Glu Arg 
                405                 410                 415     


Arg Ala Glu Val Thr Ser Asn Asn Glu Val Val Val Lys Glu Glu Tyr 
            420                 425                 430         


Lys Asp Glu Tyr Ala Asp Ile Pro Glu His Lys Pro Thr Tyr Asp Lys 
        435                 440                 445             


Met Lys 
    450 


<210>  24
<211>  48
<212>  PRT
<213>  Plasmodium falciparum

<400>  24

Met Asp Ile Thr Gln Gln Ala Lys Asp Ile Gly Ala Gly Pro Val Ala 
1               5                   10                  15      


Ser Cys Phe Thr Thr Arg Met Ser Pro Pro Gln Gln Ile Cys Leu Asn 
            20                  25                  30          


Ser Val Val Asn Thr Ala Leu Ser Thr Ser Thr Gln Ser Ala Met Lys 
        35                  40                  45              


<210>  25
<211>  113
<212>  PRT
<213>  Plasmodium falciparum

<400>  25

Lys Lys Tyr Glu Thr Tyr Val Asp Met Lys Thr Ile Glu Ser Lys Tyr 
1               5                   10                  15      


Thr Thr Val Met Thr Leu Ser Glu His Leu Leu Glu Tyr Ala Met Asp 
            20                  25                  30          


Val Leu Lys Ala Asn Pro Gln Lys Pro Ile Asp Pro Lys Ala Asn Leu 
        35                  40                  45              


Asp Ser Glu Val Val Lys Leu Gln Ile Lys Ile Asn Glu Lys Ser Asn 
    50                  55                  60                  


Glu Leu Asp Asn Ala Ala Ser Gln Val Lys Thr Leu Ile Ile Ile Met 
65                  70                  75                  80  


Lys Ser Phe Tyr Asp Ile Ile Ile Ser Glu Lys Ala Ser Met Asp Glu 
                85                  90                  95      


Met Glu Lys Lys Glu Leu Ser Leu Asn Asn Tyr Ile Glu Lys Thr Asp 
            100                 105                 110         


Tyr 
    


<210>  26
<211>  317
<212>  PRT
<213>  Plasmodium falciparum

<400>  26

Asp Ser Arg His Val Phe Ile Arg Thr Glu Leu Ser Phe Ile Lys Asn 
1               5                   10                  15      


Asn Val Pro Cys Ile Arg Asp Met Phe Phe Ile Tyr Lys Arg Glu Leu 
            20                  25                  30          


Tyr Asn Ile Cys Leu Asp Asp Leu Lys Gly Glu Glu Asp Glu Thr His 
        35                  40                  45              


Ile Tyr Val Gln Lys Lys Val Lys Asp Ser Trp Ile Thr Leu Asn Asp 
    50                  55                  60                  


Leu Phe Lys Glu Thr Asp Leu Thr Gly Arg Pro His Ile Phe Ala Tyr 
65                  70                  75                  80  


Val Asp Val Glu Glu Ile Ile Ile Leu Leu Cys Glu Asp Glu Glu Phe 
                85                  90                  95      


Ser Asn Arg Lys Lys Asp Met Thr Cys His Arg Phe Tyr Ser Asn Asp 
            100                 105                 110         


Gly Lys Glu Tyr Asn Asn Ser Glu Ile Thr Ile Ser Asp Tyr Ile Leu 
        115                 120                 125             


Lys Asp Lys Leu Leu Ser Ser Tyr Val Ser Leu Pro Leu Lys Ile Glu 
    130                 135                 140                 


Asn Arg Glu Tyr Phe Leu Ile Cys Gly Val Ser Pro Tyr Lys Phe Lys 
145                 150                 155                 160 


Asp Asp Asn Lys Lys Asp Asp Ile Leu Cys Met Ala Ser His Asp Lys 
                165                 170                 175     


Gly Glu Thr Trp Gly Thr Lys Ile Val Ile Lys Tyr Asp Asn Tyr Lys 
            180                 185                 190         


Leu Gly Val Gln Tyr Phe Phe Leu Arg Pro Tyr Ile Ser Lys Asn Asp 
        195                 200                 205             


Leu Ser Phe His Phe Tyr Val Gly Asp Asn Ile Asn Asn Val Lys Asn 
    210                 215                 220                 


Val Asn Phe Ile Glu Cys Thr His Glu Lys Asp Leu Glu Phe Val Cys 
225                 230                 235                 240 


Ser Asn Arg Asp Phe Leu Lys Asp Asn Lys Val Leu Gln Asp Val Ser 
                245                 250                 255     


Thr Leu Asn Asp Glu Tyr Ile Val Ser Tyr Gly Asn Asp Asn Asn Phe 
            260                 265                 270         


Ala Glu Cys Tyr Ile Phe Phe Asn Asn Glu Asn Ser Ile Leu Ile Lys 
        275                 280                 285             


Pro Glu Lys Tyr Gly Asn Thr Thr Ala Gly Cys Tyr Gly Gly Thr Phe 
    290                 295                 300                 


Val Lys Ile Asp Glu Asn Arg Thr Leu Phe Ile Tyr Ser 
305                 310                 315         


<210>  27
<211>  288
<212>  PRT
<213>  Plasmodium falciparum

<400>  27

Asn Glu Asp Arg Gly Ile Tyr Asp Glu Leu Leu Glu Asn Asp Met Cys 
1               5                   10                  15      


Asp Leu Tyr Asn Leu Lys Met His Asp Leu His Asn Leu Lys Ser Tyr 
            20                  25                  30          


Asp Phe Gly Leu Ser Lys Asp Leu Leu Lys Lys Asp Ile Phe Ile Tyr 
        35                  40                  45              


Ser Asn Asn Leu Lys Asn Asp Asp Met Asp Asp Asp Asp Asn Asn Asn 
    50                  55                  60                  


Met Asn Asp Ile Ala Ile Gly Glu Asn Val Ile Tyr Glu Asn Asp Ile 
65                  70                  75                  80  


His Glu Asn Asn Ile Asp Asp Asn Asp Met Tyr Asn Asn Tyr Val Asn 
                85                  90                  95      


Gly Asn Asp Leu Tyr Ile Asn Asn Met Gln Asp Asp Ala Met Asp Asp 
            100                 105                 110         


Ile Val Tyr Asp Glu Glu Glu Ile Lys Ser Phe Leu Asp Lys Leu Lys 
        115                 120                 125             


Ser Asp Ile Ser Asn Gln Met Asn Val Lys Asn Gly Asn Val Glu Val 
    130                 135                 140                 


Thr Gly Asn Gly Gly Asn Glu Glu Met Ser Tyr Ile Asn Asn Asp Glu 
145                 150                 155                 160 


Asn Leu Gln Ala Phe Asp Leu Leu Asp Asn Phe His Met Asp Asp Tyr 
                165                 170                 175     


Gly Asn Asn Tyr Asn Asp Asn Glu Glu Asp Gly Asp Gly Asp Gly Asp 
            180                 185                 190         


Asp Asp Glu Gln Lys Lys Arg Lys Gln Lys Glu Leu His Asn Val Asn 
        195                 200                 205             


Gly Lys Leu Asp Leu Ser Asp Leu Asn Glu Leu Asn Val Asp Asp Ile 
    210                 215                 220                 


Asn Asn Asn Phe Tyr Met Ser Thr Pro Arg Lys Ser Ile Asp Glu Arg 
225                 230                 235                 240 


Lys Asp Thr Glu Cys Gln Thr Asp Phe Pro Leu Leu Asp Val Ser Arg 
                245                 250                 255     


Asn Thr Asp Arg Thr Pro Arg Arg Lys Ser Val Glu Val Ile Leu Val 
            260                 265                 270         


Glu Ala Ala Ala His His His His His His Ser Glu Lys Asp Glu Leu 
        275                 280                 285             


<210>  28
<211>  520
<212>  PRT
<213>  Plasmodium falciparum

<400>  28

Gln Asn Tyr Trp Glu His Pro Tyr Gln Lys Ser Asp Val Tyr His Pro 
1               5                   10                  15      


Ile Asn Glu His Arg Glu His Pro Lys Glu Tyr Glu Tyr Pro Leu His 
            20                  25                  30          


Gln Glu His Thr Tyr Gln Gln Glu Asp Ser Gly Glu Asp Glu Asn Thr 
        35                  40                  45              


Leu Gln His Ala Tyr Pro Ile Asp His Glu Gly Ala Glu Pro Ala Pro 
    50                  55                  60                  


Gln Glu Gln Asn Leu Phe Ser Ser Ile Glu Ile Val Glu Arg Ser Asn 
65                  70                  75                  80  


Tyr Met Gly Asn Pro Trp Thr Glu Tyr Met Ala Lys Tyr Asp Ile Glu 
                85                  90                  95      


Glu Val His Gly Ser Gly Ile Arg Val Asp Leu Gly Glu Asp Ala Glu 
            100                 105                 110         


Val Ala Gly Thr Gln Tyr Arg Leu Pro Ser Gly Lys Cys Pro Val Phe 
        115                 120                 125             


Gly Lys Gly Ile Ile Ile Glu Asn Ser Gln Thr Thr Phe Leu Thr Pro 
    130                 135                 140                 


Val Ala Thr Glu Asn Gln Asp Leu Lys Asp Gly Gly Phe Ala Phe Pro 
145                 150                 155                 160 


Pro Thr Lys Pro Leu Met Ser Pro Met Thr Leu Asp Gln Met Arg His 
                165                 170                 175     


Phe Tyr Lys Asp Asn Glu Tyr Val Lys Asn Leu Asp Glu Leu Thr Leu 
            180                 185                 190         


Cys Ser Arg His Ala Gly Asn Met Asn Pro Asp Asn Asp Lys Asn Ser 
        195                 200                 205             


Asn Tyr Lys Tyr Pro Ala Val Tyr Asp Asp Lys Asp Lys Lys Cys His 
    210                 215                 220                 


Ile Leu Tyr Ile Ala Ala Gln Glu Asn Asn Gly Pro Arg Tyr Cys Asn 
225                 230                 235                 240 


Lys Asp Glu Ser Lys Arg Asn Ser Met Phe Cys Phe Arg Pro Ala Lys 
                245                 250                 255     


Asp Lys Ser Phe Gln Asn Tyr Val Tyr Leu Ser Lys Asn Val Val Asp 
            260                 265                 270         


Asn Trp Glu Lys Val Cys Pro Arg Lys Asn Leu Glu Asn Ala Lys Phe 
        275                 280                 285             


Gly Leu Trp Val Asp Gly Asn Cys Glu Asp Ile Pro His Val Asn Glu 
    290                 295                 300                 


Phe Ser Ala Asn Asp Leu Phe Glu Cys Asn Lys Leu Val Phe Glu Leu 
305                 310                 315                 320 


Ser Ala Ser Asp Gln Pro Lys Gln Tyr Glu Gln His Leu Thr Asp Tyr 
                325                 330                 335     


Glu Lys Ile Lys Glu Gly Phe Lys Asn Lys Asn Ala Asp Met Ile Arg 
            340                 345                 350         


Ser Ala Phe Leu Pro Thr Gly Ala Phe Lys Ala Asp Arg Tyr Lys Ser 
        355                 360                 365             


His Gly Lys Gly Tyr Asn Trp Gly Asn Tyr Asn Arg Lys Thr Gln Lys 
    370                 375                 380                 


Cys Glu Ile Phe Asn Val Lys Pro Thr Cys Leu Ile Asn Asp Lys Ser 
385                 390                 395                 400 


Tyr Ile Ala Thr Thr Ala Leu Ser His Pro Ile Glu Val Glu His Asn 
                405                 410                 415     


Phe Pro Cys Ser Leu Tyr Lys Asp Glu Ile Lys Lys Glu Ile Glu Arg 
            420                 425                 430         


Glu Ser Lys Arg Ile Lys Leu Asn Asp Asn Asp Asp Glu Gly Asn Lys 
        435                 440                 445             


Lys Ile Ile Ala Pro Arg Ile Phe Ile Ser Asp Asp Lys Asp Ser Leu 
    450                 455                 460                 


Lys Cys Pro Cys Asp Pro Glu Ile Val Ser Gln Ser Thr Cys Asn Phe 
465                 470                 475                 480 


Phe Val Cys Lys Cys Val Glu Lys Arg Ala Glu Val Thr Ser Asn Asn 
                485                 490                 495     


Glu Val Val Val Lys Glu Glu Tyr Lys Asp Glu Tyr Ala Asp Ile Pro 
            500                 505                 510         


Glu His Lys Pro Thr Tyr Asp Lys 
        515                 520 


<210>  29
<211>  520
<212>  PRT
<213>  Plasmodium falciparum

<400>  29

Gln Asn Tyr Trp Glu His Pro Tyr Gln Lys Ser Asp Val Tyr His Pro 
1               5                   10                  15      


Ile Asn Glu His Arg Glu His Pro Lys Glu Tyr Glu Tyr Pro Leu His 
            20                  25                  30          


Gln Glu His Thr Tyr Gln Gln Glu Asp Ser Gly Glu Asp Glu Asn Thr 
        35                  40                  45              


Leu Gln His Ala Tyr Pro Ile Asp His Glu Gly Ala Glu Pro Ala Pro 
    50                  55                  60                  


Gln Glu Gln Asn Leu Phe Ser Ser Ile Glu Ile Val Glu Arg Ser Asn 
65                  70                  75                  80  


Tyr Met Gly Asn Pro Trp Thr Glu Tyr Met Ala Lys Tyr Asp Ile Glu 
                85                  90                  95      


Glu Val His Gly Ser Gly Ile Arg Val Asp Leu Gly Glu Asp Ala Glu 
            100                 105                 110         


Val Ala Gly Thr Gln Tyr Arg Leu Pro Ser Gly Lys Cys Pro Val Phe 
        115                 120                 125             


Gly Lys Gly Ile Ile Ile Glu Asn Ser Gln Thr Thr Phe Leu Lys Pro 
    130                 135                 140                 


Val Ala Thr Gly Asn Gln Asp Leu Lys Asp Gly Gly Phe Ala Phe Pro 
145                 150                 155                 160 


Pro Thr Asn Pro Leu Ile Ser Pro Met Thr Leu Asn Gly Met Arg Asp 
                165                 170                 175     


Phe Tyr Lys Asn Asn Glu Tyr Val Lys Asn Leu Asp Glu Leu Thr Leu 
            180                 185                 190         


Cys Ser Arg His Ala Gly Asn Met Asn Pro Asp Asn Asp Glu Asn Ser 
        195                 200                 205             


Asn Tyr Lys Tyr Pro Ala Val Tyr Asp Tyr Asn Asp Lys Lys Cys His 
    210                 215                 220                 


Ile Leu Tyr Ile Ala Ala Gln Glu Asn Asn Gly Pro Arg Tyr Cys Asn 
225                 230                 235                 240 


Lys Asp Glu Ser Lys Arg Asn Ser Met Phe Cys Phe Arg Pro Ala Lys 
                245                 250                 255     


Asp Lys Leu Phe Glu Asn Tyr Val Tyr Leu Ser Lys Asn Val Val His 
            260                 265                 270         


Asn Trp Glu Glu Val Cys Pro Arg Lys Asn Leu Glu Asn Ala Lys Phe 
        275                 280                 285             


Gly Leu Trp Val Asp Gly Asn Cys Glu Asp Ile Pro His Val Asn Glu 
    290                 295                 300                 


Phe Ser Ala Asn Asp Leu Phe Glu Cys Asn Lys Leu Val Phe Glu Leu 
305                 310                 315                 320 


Ser Ala Ser Asp Gln Pro Lys Gln Tyr Glu Gln His Leu Thr Asp Tyr 
                325                 330                 335     


Glu Lys Ile Lys Glu Gly Phe Lys Asn Lys Asn Ala Asp Met Ile Arg 
            340                 345                 350         


Ser Ala Phe Leu Pro Thr Gly Ala Phe Lys Ala Asp Arg Tyr Lys Ser 
        355                 360                 365             


Arg Gly Lys Gly Tyr Asn Trp Gly Asn Tyr Asn Arg Lys Thr Gln Lys 
    370                 375                 380                 


Cys Glu Ile Phe Asn Val Lys Pro Thr Cys Leu Ile Asn Asp Lys Ser 
385                 390                 395                 400 


Tyr Ile Ala Thr Thr Ala Leu Ser His Pro Ile Glu Val Glu Asn Asn 
                405                 410                 415     


Phe Pro Cys Ser Leu Tyr Lys Asn Glu Ile Met Lys Glu Ile Glu Arg 
            420                 425                 430         


Glu Ser Lys Arg Ile Lys Leu Asn Asp Asn Asp Asp Glu Gly Asn Lys 
        435                 440                 445             


Lys Ile Ile Ala Pro Arg Ile Phe Ile Ser Asp Asp Lys Asp Ser Leu 
    450                 455                 460                 


Lys Cys Pro Cys Asp Pro Glu Met Val Ser Gln Ser Thr Cys Arg Phe 
465                 470                 475                 480 


Phe Val Cys Lys Cys Val Glu Arg Arg Ala Glu Val Thr Ser Asn Asn 
                485                 490                 495     


Glu Val Val Val Lys Glu Glu Tyr Lys Asp Glu Tyr Ala Asp Ile Pro 
            500                 505                 510         


Glu His Lys Pro Thr Tyr Asp Asn 
        515                 520 


<210>  30
<211>  520
<212>  PRT
<213>  Plasmodium falciparum

<400>  30

Gln Asn Tyr Trp Glu His Pro Tyr Gln Lys Ser Asp Val Tyr His Pro 
1               5                   10                  15      


Ile Asn Glu His Arg Glu His Pro Lys Glu Tyr Glu Tyr Pro Leu His 
            20                  25                  30          


Gln Glu His Thr Tyr Gln Gln Glu Asp Ser Gly Glu Asp Glu Asn Thr 
        35                  40                  45              


Leu Gln His Ala Tyr Pro Ile Asp His Glu Gly Ala Glu Pro Ala Pro 
    50                  55                  60                  


Gln Glu Gln Asn Leu Phe Ser Ser Ile Glu Ile Val Glu Arg Ser Asn 
65                  70                  75                  80  


Tyr Met Gly Asn Pro Trp Thr Glu Tyr Met Ala Lys Tyr Asp Ile Glu 
                85                  90                  95      


Glu Val His Gly Ser Gly Ile Arg Val Asp Leu Gly Glu Asp Ala Glu 
            100                 105                 110         


Val Ala Gly Thr Gln Tyr Arg Leu Pro Ser Gly Lys Cys Pro Val Phe 
        115                 120                 125             


Gly Lys Gly Ile Ile Ile Glu Asn Ser Lys Thr Thr Phe Leu Thr Pro 
    130                 135                 140                 


Val Ala Thr Glu Asn Gln Asp Leu Lys Asp Gly Gly Phe Ala Phe Pro 
145                 150                 155                 160 


Pro Thr Glu Pro Leu Met Ser Pro Met Thr Leu Asp Asp Met Arg Asp 
                165                 170                 175     


Leu Tyr Lys Asp Asn Lys Tyr Val Lys Asn Leu Asp Glu Leu Thr Leu 
            180                 185                 190         


Cys Ser Arg His Ala Gly Asn Met Ile Pro Asp Asn Asp Lys Asn Ser 
        195                 200                 205             


Asn Tyr Lys Tyr Pro Ala Val Tyr Asp Tyr Glu Asp Lys Lys Cys His 
    210                 215                 220                 


Ile Leu Tyr Ile Ala Ala Gln Glu Asn Asn Gly Pro Arg Tyr Cys Asn 
225                 230                 235                 240 


Lys Asp Gln Ser Lys Arg Asn Ser Met Phe Cys Phe Arg Pro Ala Lys 
                245                 250                 255     


Asp Ile Ser Phe Gln Asn Tyr Val Tyr Leu Ser Lys Asn Val Val Asp 
            260                 265                 270         


Asn Trp Glu Lys Val Cys Pro Arg Lys Asn Leu Gln Asn Ala Lys Phe 
        275                 280                 285             


Gly Leu Trp Val Asp Gly Asn Cys Glu Asp Ile Pro His Val Asn Glu 
    290                 295                 300                 


Phe Ser Ala Ile Asp Leu Phe Glu Cys Asn Lys Leu Val Phe Glu Leu 
305                 310                 315                 320 


Ser Ala Ser Asp Gln Pro Lys Gln Tyr Glu Gln His Leu Thr Asp Tyr 
                325                 330                 335     


Glu Lys Ile Lys Glu Gly Phe Lys Asn Lys Asn Ala Asp Met Ile Arg 
            340                 345                 350         


Ser Ala Phe Leu Pro Thr Gly Ala Phe Lys Ala Asp Arg Tyr Lys Ser 
        355                 360                 365             


His Gly Lys Gly Tyr Asn Trp Gly Asn Tyr Asn Thr Glu Thr Gln Lys 
    370                 375                 380                 


Cys Glu Ile Phe Asn Val Lys Pro Thr Cys Leu Ile Asn Asp Lys Ser 
385                 390                 395                 400 


Tyr Ile Ala Thr Thr Ala Leu Ser His Pro Asn Glu Val Glu His Asn 
                405                 410                 415     


Phe Pro Cys Ser Leu Tyr Lys Asp Glu Ile Lys Lys Glu Ile Glu Arg 
            420                 425                 430         


Glu Ser Lys Arg Ile Lys Leu Asn Asp Asn Asp Asp Glu Gly Asn Lys 
        435                 440                 445             


Lys Ile Ile Ala Pro Arg Ile Phe Ile Ser Asp Asp Ile Asp Ser Leu 
    450                 455                 460                 


Lys Cys Pro Cys Ala Pro Glu Ile Val Ser Gln Ser Thr Cys Asn Phe 
465                 470                 475                 480 


Phe Val Cys Lys Cys Val Glu Lys Arg Ala Glu Val Thr Ser Asn Asn 
                485                 490                 495     


Glu Val Val Val Lys Glu Glu Tyr Lys Asp Glu Tyr Ala Asp Ile Pro 
            500                 505                 510         


Glu His Lys Pro Thr Tyr Asp Lys 
        515                 520 


<210>  31
<211>  502
<212>  PRT
<213>  Plasmodium falciparum

<400>  31

Phe Glu Asn Ala Ile Lys Lys Thr Lys Asn Gln Glu Asn Asn Leu Ala 
1               5                   10                  15      


Leu Leu Pro Ile Lys Ser Thr Glu Glu Glu Lys Asp Asp Ile Lys Asn 
            20                  25                  30          


Gly Lys Asp Ile Lys Lys Glu Ile Asp Asn Asp Lys Glu Asn Ile Lys 
        35                  40                  45              


Thr Asn Asn Ala Lys Asp His Ser Thr Tyr Ile Lys Ser Tyr Leu Asn 
    50                  55                  60                  


Thr Asn Val Asn Asp Gly Leu Lys Tyr Leu Phe Ile Pro Ser His Asn 
65                  70                  75                  80  


Ser Phe Ile Lys Lys Tyr Ser Val Phe Asn Gln Ile Asn Asp Gly Met 
                85                  90                  95      


Leu Leu Asn Glu Lys Asn Asp Val Lys Asn Asn Glu Asp Tyr Lys Asn 
            100                 105                 110         


Val Asp Tyr Lys Asn Val Asn Phe Leu Gln Tyr His Phe Lys Glu Leu 
        115                 120                 125             


Ser Asn Tyr Asn Ile Ala Asn Ser Ile Asp Ile Leu Gln Glu Lys Glu 
    130                 135                 140                 


Gly His Leu Asp Phe Val Ile Ile Pro His Tyr Thr Phe Leu Asp Tyr 
145                 150                 155                 160 


Tyr Lys His Leu Ser Tyr Asn Ser Ile Tyr His Lys Ser Ser Thr Tyr 
                165                 170                 175     


Gly Lys Cys Ile Ala Val Asp Ala Phe Ile Lys Lys Ile Asn Glu Ala 
            180                 185                 190         


Tyr Asp Lys Val Lys Ser Lys Cys Asn Asp Ile Lys Asn Asp Leu Ile 
        195                 200                 205             


Ala Thr Ile Lys Lys Leu Glu His Pro Tyr Asp Ile Asn Asn Lys Asn 
    210                 215                 220                 


Asp Asp Ser Tyr Arg Tyr Asp Ile Ser Glu Glu Ile Asp Asp Lys Ser 
225                 230                 235                 240 


Glu Glu Thr Asp Asp Glu Thr Glu Glu Val Glu Asp Ser Ile Gln Asp 
                245                 250                 255     


Thr Asp Ser Asn His Ala Pro Ser Asn Lys Lys Lys Asn Asp Leu Met 
            260                 265                 270         


Asn Arg Ala Phe Lys Lys Met Met Asp Glu Tyr Asn Thr Lys Lys Lys 
        275                 280                 285             


Lys Leu Ile Lys Cys Ile Lys Asn His Glu Asn Asp Phe Asn Lys Ile 
    290                 295                 300                 


Cys Met Asp Met Lys Asn Tyr Gly Thr Asn Leu Phe Glu Gln Leu Ser 
305                 310                 315                 320 


Cys Tyr Asn Asn Asn Phe Cys Asn Thr Asn Gly Ile Arg Tyr His Tyr 
                325                 330                 335     


Asp Glu Tyr Ile His Lys Leu Ile Leu Ser Val Lys Ser Lys Asn Leu 
            340                 345                 350         


Asn Lys Asp Leu Ser Asp Met Thr Asn Ile Leu Gln Gln Ser Glu Leu 
        355                 360                 365             


Leu Leu Thr Asn Leu Asn Lys Lys Met Gly Ser Tyr Ile Tyr Ile Asp 
    370                 375                 380                 


Thr Ile Lys Phe Ile His Lys Glu Met Lys His Ile Phe Asn Arg Ile 
385                 390                 395                 400 


Glu Tyr His Thr Lys Ile Ile Asn Asp Lys Thr Lys Ile Ile Gln Asp 
                405                 410                 415     


Lys Ile Lys Leu Asn Ile Trp Arg Thr Phe Gln Lys Asp Glu Leu Leu 
            420                 425                 430         


Lys Arg Ile Leu Asp Met Ser Asn Glu Tyr Ser Leu Phe Ile Thr Ser 
        435                 440                 445             


Asp His Leu Arg Gln Met Leu Tyr Asn Thr Phe Tyr Ser Lys Glu Lys 
    450                 455                 460                 


His Leu Asn Asn Ile Phe His His Leu Ile Tyr Val Leu Gln Met Lys 
465                 470                 475                 480 


Phe Asn Asp Val Pro Ile Lys Met Glu Tyr Phe Gln Thr Tyr Lys Lys 
                485                 490                 495     


Asn Lys Pro Leu Thr Gln 
            500         


<210>  32
<211>  333
<212>  PRT
<213>  Homo sapiens

<400>  32

Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
1               5                   10                  15      


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
            20                  25                  30          


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
        35                  40                  45              


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
    50                  55                  60                  


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
65                  70                  75                  80  


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu 
                85                  90                  95      


Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
            100                 105                 110         


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        115                 120                 125             


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    130                 135                 140                 


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
145                 150                 155                 160 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
                165                 170                 175     


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            180                 185                 190         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Phe 
        195                 200                 205             


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    210                 215                 220                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
225                 230                 235                 240 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                245                 250                 255     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            260                 265                 270         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        275                 280                 285             


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
    290                 295                 300                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
305                 310                 315                 320 


Leu Ser Leu Ser Pro Gly Lys Ser Glu Lys Asp Glu Leu 
                325                 330             


<210>  33
<211>  431
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Malaria Immunoassemblin heavy chain fusion polypeptide

<400>  33

Ile Ser Gln His Gln Cys Val Lys Lys Gln Cys Pro Glu Asn Ser Gly 
1               5                   10                  15      


Cys Phe Arg His Leu Asp Glu Arg Glu Glu Cys Lys Cys Leu Leu Asn 
            20                  25                  30          


Tyr Lys Gln Glu Gly Asp Lys Cys Val Glu Asn Pro Asn Pro Thr Cys 
        35                  40                  45              


Asn Glu Asn Asn Gly Gly Cys Asp Ala Asp Ala Thr Cys Thr Glu Glu 
    50                  55                  60                  


Asp Ser Gly Ser Ser Arg Lys Lys Ile Thr Cys Glu Cys Thr Lys Pro 
65                  70                  75                  80  


Asp Ser Tyr Pro Leu Phe Asp Gly Ile Phe Cys Ser Ser Ser Asn Ala 
                85                  90                  95      


Ala Ala Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
            100                 105                 110         


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
        115                 120                 125             


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
    130                 135                 140                 


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
145                 150                 155                 160 


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
                165                 170                 175     


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys 
            180                 185                 190         


Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
        195                 200                 205             


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
    210                 215                 220                 


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
225                 230                 235                 240 


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
                245                 250                 255     


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
            260                 265                 270         


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
        275                 280                 285             


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
    290                 295                 300                 


Ala Phe Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
305                 310                 315                 320 


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
                325                 330                 335     


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
            340                 345                 350         


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
        355                 360                 365             


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
    370                 375                 380                 


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
385                 390                 395                 400 


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
                405                 410                 415     


Lys Ser Leu Ser Leu Ser Pro Gly Lys Ser Glu Lys Asp Glu Leu 
            420                 425                 430     


<210>  34
<211>  734
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Malaria Immunoassemblin heavy chain fusion polypeptide

<400>  34

Ile Ser Gln His Gln Cys Val Lys Lys Gln Cys Pro Glu Asn Ser Gly 
1               5                   10                  15      


Cys Phe Arg His Leu Asp Glu Arg Glu Glu Cys Lys Cys Leu Leu Asn 
            20                  25                  30          


Tyr Lys Gln Glu Gly Asp Lys Cys Val Glu Asn Pro Asn Pro Thr Cys 
        35                  40                  45              


Asn Glu Asn Asn Gly Gly Cys Asp Ala Asp Ala Thr Cys Thr Glu Glu 
    50                  55                  60                  


Asp Ser Gly Ser Ser Arg Lys Lys Ile Thr Cys Glu Cys Thr Lys Pro 
65                  70                  75                  80  


Asp Ser Tyr Pro Leu Phe Asp Gly Ile Phe Cys Ser Ser Ser Asn Ala 
                85                  90                  95      


Ala Val Ala Met Ala Ile Ser Gln His Gln Cys Val Lys Lys Gln Cys 
            100                 105                 110         


Pro Glu Asn Ser Gly Cys Phe Arg His Leu Asp Glu Arg Glu Glu Cys 
        115                 120                 125             


Lys Cys Leu Leu Asn Tyr Lys Gln Glu Gly Asp Lys Cys Val Glu Asn 
    130                 135                 140                 


Pro Asn Pro Thr Cys Asn Glu Asn Asn Gly Gly Cys Asp Ala Asp Ala 
145                 150                 155                 160 


Lys Cys Thr Glu Glu Asp Ser Gly Ser Asn Gly Lys Lys Ile Thr Cys 
                165                 170                 175     


Glu Cys Thr Lys Pro Asp Ser Tyr Pro Leu Phe Asp Gly Ile Phe Cys 
            180                 185                 190         


Ser Ser Ser Asn Ala Ala Val Ala Met Ala Ile Ser Gln His Gln Cys 
        195                 200                 205             


Val Lys Lys Gln Cys Pro Gln Asn Ser Gly Cys Phe Arg His Leu Asp 
    210                 215                 220                 


Glu Arg Glu Glu Cys Lys Cys Leu Leu Asn Tyr Lys Gln Glu Gly Asp 
225                 230                 235                 240 


Lys Cys Val Glu Asn Pro Asn Pro Thr Cys Asn Glu Asn Asn Gly Gly 
                245                 250                 255     


Cys Asp Ala Asp Ala Lys Cys Thr Glu Glu Asp Ser Gly Ser Asn Gly 
            260                 265                 270         


Lys Lys Ile Thr Cys Glu Cys Thr Lys Pro Asp Ser Tyr Pro Leu Phe 
        275                 280                 285             


Asp Gly Ile Phe Cys Ser Ser Ser Asn Ala Ala Val Ala Met Ala Ile 
    290                 295                 300                 


Ser Gln His Gln Cys Val Lys Lys Gln Cys Pro Gln Asn Ser Gly Cys 
305                 310                 315                 320 


Phe Arg His Leu Asp Glu Arg Glu Glu Cys Lys Cys Leu Leu Asn Tyr 
                325                 330                 335     


Lys Gln Glu Gly Asp Lys Cys Val Glu Asn Pro Asn Pro Thr Cys Asn 
            340                 345                 350         


Glu Asn Asn Gly Gly Cys Asp Ala Asp Ala Lys Cys Thr Glu Glu Asp 
        355                 360                 365             


Ser Gly Ser Asn Gly Lys Lys Ile Thr Cys Glu Cys Thr Lys Pro Asp 
    370                 375                 380                 


Ser Tyr Pro Phe Phe Asp Gly Ile Phe Cys Ser Ser Ser Asn Ala Ala 
385                 390                 395                 400 


Ala Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 
                405                 410                 415     


Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
            420                 425                 430         


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
        435                 440                 445             


His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
    450                 455                 460                 


Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 
465                 470                 475                 480 


Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val 
                485                 490                 495     


Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
            500                 505                 510         


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
        515                 520                 525             


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
    530                 535                 540                 


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
545                 550                 555                 560 


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
                565                 570                 575     


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
            580                 585                 590         


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
        595                 600                 605             


Phe Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
    610                 615                 620                 


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
625                 630                 635                 640 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
                645                 650                 655     


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
            660                 665                 670         


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
        675                 680                 685             


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
    690                 695                 700                 


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
705                 710                 715                 720 


Ser Leu Ser Leu Ser Pro Gly Lys Ser Glu Lys Asp Glu Leu 
                725                 730                 


<210>  35
<211>  842
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MIA HC fusion

<400>  35

Ile Ser Gln His Gln Cys Val Lys Lys Gln Cys Pro Glu Asn Ser Gly 
1               5                   10                  15      


Cys Phe Arg His Leu Asp Glu Arg Glu Glu Cys Lys Cys Leu Leu Asn 
            20                  25                  30          


Tyr Lys Gln Glu Gly Asp Lys Cys Val Glu Asn Pro Asn Pro Thr Cys 
        35                  40                  45              


Asn Glu Asn Asn Gly Gly Cys Asp Ala Asp Ala Thr Cys Thr Glu Glu 
    50                  55                  60                  


Asp Ser Gly Ser Ser Arg Lys Lys Ile Thr Cys Glu Cys Thr Lys Pro 
65                  70                  75                  80  


Asp Ser Tyr Pro Leu Phe Asp Gly Ile Phe Cys Ser Ser Ser Asn Ala 
                85                  90                  95      


Ala Val Ala Met Ala Ile Ser Gln His Gln Cys Val Lys Lys Gln Cys 
            100                 105                 110         


Pro Glu Asn Ser Gly Cys Phe Arg His Leu Asp Glu Arg Glu Glu Cys 
        115                 120                 125             


Lys Cys Leu Leu Asn Tyr Lys Gln Glu Gly Asp Lys Cys Val Glu Asn 
    130                 135                 140                 


Pro Asn Pro Thr Cys Asn Glu Asn Asn Gly Gly Cys Asp Ala Asp Ala 
145                 150                 155                 160 


Lys Cys Thr Glu Glu Asp Ser Gly Ser Asn Gly Lys Lys Ile Thr Cys 
                165                 170                 175     


Glu Cys Thr Lys Pro Asp Ser Tyr Pro Leu Phe Asp Gly Ile Phe Cys 
            180                 185                 190         


Ser Ser Ser Asn Ala Ala Val Ala Met Ala Ile Ser Gln His Gln Cys 
        195                 200                 205             


Val Lys Lys Gln Cys Pro Gln Asn Ser Gly Cys Phe Arg His Leu Asp 
    210                 215                 220                 


Glu Arg Glu Glu Cys Lys Cys Leu Leu Asn Tyr Lys Gln Glu Gly Asp 
225                 230                 235                 240 


Lys Cys Val Glu Asn Pro Asn Pro Thr Cys Asn Glu Asn Asn Gly Gly 
                245                 250                 255     


Cys Asp Ala Asp Ala Lys Cys Thr Glu Glu Asp Ser Gly Ser Asn Gly 
            260                 265                 270         


Lys Lys Ile Thr Cys Glu Cys Thr Lys Pro Asp Ser Tyr Pro Leu Phe 
        275                 280                 285             


Asp Gly Ile Phe Cys Ser Ser Ser Asn Ala Ala Val Ala Met Ala Ile 
    290                 295                 300                 


Ser Gln His Gln Cys Val Lys Lys Gln Cys Pro Gln Asn Ser Gly Cys 
305                 310                 315                 320 


Phe Arg His Leu Asp Glu Arg Glu Glu Cys Lys Cys Leu Leu Asn Tyr 
                325                 330                 335     


Lys Gln Glu Gly Asp Lys Cys Val Glu Asn Pro Asn Pro Thr Cys Asn 
            340                 345                 350         


Glu Asn Asn Gly Gly Cys Asp Ala Asp Ala Lys Cys Thr Glu Glu Asp 
        355                 360                 365             


Ser Gly Ser Asn Gly Lys Lys Ile Thr Cys Glu Cys Thr Lys Pro Asp 
    370                 375                 380                 


Ser Tyr Pro Phe Phe Asp Gly Ile Phe Cys Ser Ser Ser Asn Ala Ala 
385                 390                 395                 400 


Ala Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 
                405                 410                 415     


Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
            420                 425                 430         


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
        435                 440                 445             


His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
    450                 455                 460                 


Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 
465                 470                 475                 480 


Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val 
                485                 490                 495     


Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
            500                 505                 510         


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
        515                 520                 525             


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
    530                 535                 540                 


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
545                 550                 555                 560 


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
                565                 570                 575     


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
            580                 585                 590         


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
        595                 600                 605             


Phe Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
    610                 615                 620                 


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
625                 630                 635                 640 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
                645                 650                 655     


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
            660                 665                 670         


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
        675                 680                 685             


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
    690                 695                 700                 


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
705                 710                 715                 720 


Ser Leu Ser Leu Ser Pro Gly Lys His Met Leu Asn Ile Ser Gln His 
                725                 730                 735     


Gln Cys Val Lys Lys Gln Cys Pro Glu Asn Ser Gly Cys Phe Arg His 
            740                 745                 750         


Leu Asp Glu Arg Glu Glu Cys Lys Cys Leu Leu Asn Tyr Lys Gln Glu 
        755                 760                 765             


Gly Asp Lys Cys Val Glu Asn Pro Asn Pro Thr Cys Asn Glu Asn Asn 
    770                 775                 780                 


Gly Gly Cys Asp Ala Asp Ala Thr Cys Thr Glu Glu Asp Ser Gly Ser 
785                 790                 795                 800 


Ser Arg Lys Lys Ile Thr Cys Glu Cys Thr Lys Pro Asp Ser Tyr Pro 
                805                 810                 815     


Leu Phe Asp Gly Ile Phe Cys Ser Ser Ser Asn Ala Ala Ala His His 
            820                 825                 830         


His His His His Ser Glu Lys Asp Glu Leu 
        835                 840         


<210>  36
<211>  505
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Malaria Immunoassemblin heavy chain fusion polypeptide

<400>  36

Val Thr Val Asp Thr Val Cys Lys Arg Gly Phe Leu Ile Gln Met Ser 
1               5                   10                  15      


Gly His Leu Glu Cys Lys Cys Glu Asn Asp Leu Val Leu Val Asn Glu 
            20                  25                  30          


Glu Thr Cys Glu Glu Lys Val Leu Lys Cys Asp Glu Lys Thr Val Asn 
        35                  40                  45              


Lys Pro Cys Gly Asp Phe Ser Lys Cys Ile Lys Ile Asp Gly Asn Pro 
    50                  55                  60                  


Val Ser Tyr Ala Cys Lys Cys Asn Leu Gly Tyr Asp Met Val Asn Asn 
65                  70                  75                  80  


Val Cys Ile Pro Asn Glu Cys Lys Asn Val Ala Cys Gly Asn Gly Lys 
                85                  90                  95      


Cys Ile Leu Asp Thr Ser Asn Pro Val Lys Thr Gly Val Cys Ser Cys 
            100                 105                 110         


Asn Ile Gly Lys Val Pro Asn Val Gln Asp Gln Lys Cys Ser Lys Asp 
        115                 120                 125             


Gly Glu Thr Lys Cys Ser Leu Lys Cys Leu Lys Glu Asn Glu Ala Cys 
    130                 135                 140                 


Lys Ala Val Asp Gly Ile Tyr Lys Cys Asp Cys Lys Asp Gly Phe Ile 
145                 150                 155                 160 


Ile Asp Asn Glu Ala Ser Ile Cys Thr Ala Ala Ala Lys Gly Pro Ser 
                165                 170                 175     


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
            180                 185                 190         


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
        195                 200                 205             


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
    210                 215                 220                 


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
225                 230                 235                 240 


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
                245                 250                 255     


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
            260                 265                 270         


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
        275                 280                 285             


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
    290                 295                 300                 


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
305                 310                 315                 320 


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
                325                 330                 335     


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
            340                 345                 350         


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
        355                 360                 365             


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Phe Pro Ala Pro Ile 
    370                 375                 380                 


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
385                 390                 395                 400 


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
                405                 410                 415     


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
            420                 425                 430         


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
        435                 440                 445             


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
    450                 455                 460                 


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
465                 470                 475                 480 


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
                485                 490                 495     


Pro Gly Lys Ser Glu Lys Asp Glu Leu 
            500                 505 


<210>  37
<211>  505
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Malaria Immunoassemblin heavy chain fusion polypeptide

<400>  37

Val Thr Val Asp Thr Val Cys Lys Arg Gly Phe Leu Ile Gln Met Ser 
1               5                   10                  15      


Gly His Leu Glu Cys Lys Cys Glu Asn Asp Thr Val Leu Val Asn Glu 
            20                  25                  30          


Glu Thr Cys Glu Glu Lys Val Leu Lys Cys Asp Glu Lys Thr Val Asn 
        35                  40                  45              


Lys Pro Cys Gly Asp Phe Ser Lys Cys Ile Lys Ile Asp Gly Asn Pro 
    50                  55                  60                  


Val Ser Tyr Ala Cys Lys Cys Asn Leu Gly Tyr Asp Met Val Asn Asn 
65                  70                  75                  80  


Val Cys Ile Pro Asn Glu Cys Lys Asn Val Thr Cys Gly Asn Gly Lys 
                85                  90                  95      


Cys Ile Leu Asp Thr Ser Asn Pro Val Lys Thr Gly Val Cys Ser Cys 
            100                 105                 110         


Asn Ile Gly Lys Val Pro Asn Val Gln Asp Gln Lys Cys Ser Lys Asp 
        115                 120                 125             


Gly Glu Thr Lys Cys Ser Leu Lys Cys Leu Lys Glu Asn Glu Thr Cys 
    130                 135                 140                 


Lys Ala Val Asp Gly Ile Tyr Lys Cys Asp Cys Lys Asp Gly Phe Ile 
145                 150                 155                 160 


Ile Asp Asn Glu Ala Ser Ile Cys Thr Ala Ala Ala Lys Gly Pro Ser 
                165                 170                 175     


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
            180                 185                 190         


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
        195                 200                 205             


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
    210                 215                 220                 


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
225                 230                 235                 240 


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
                245                 250                 255     


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
            260                 265                 270         


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
        275                 280                 285             


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
    290                 295                 300                 


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
305                 310                 315                 320 


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
                325                 330                 335     


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
            340                 345                 350         


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
        355                 360                 365             


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Phe Pro Ala Pro Ile 
    370                 375                 380                 


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
385                 390                 395                 400 


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
                405                 410                 415     


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
            420                 425                 430         


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
        435                 440                 445             


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
    450                 455                 460                 


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
465                 470                 475                 480 


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
                485                 490                 495     


Pro Gly Lys Ser Glu Lys Asp Glu Leu 
            500                 505 


<210>  38
<211>  505
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Malaria Immunoassemblin heavy chain fusion polypeptide

<400>  38

Val Thr Glu Asn Thr Ile Cys Lys Tyr Gly Tyr Leu Ile Gln Met Ser 
1               5                   10                  15      


Asn His Tyr Glu Cys Lys Cys Ile Glu Gly Tyr Val Leu Ile Asn Glu 
            20                  25                  30          


Asp Thr Cys Gly Lys Lys Val Val Cys Asp Lys Val Glu Asn Ser Phe 
        35                  40                  45              


Lys Ala Cys Asp Glu Tyr Ala Tyr Cys Phe Asp Leu Gly Asn Lys Asn 
    50                  55                  60                  


Asn Glu Lys Gln Ile Lys Cys Met Cys Arg Thr Glu Tyr Thr Leu Thr 
65                  70                  75                  80  


Ala Gly Val Cys Val Pro Asn Val Cys Arg Asp Lys Val Cys Gly Lys 
                85                  90                  95      


Gly Lys Cys Ile Val Asp Pro Ala Asn Ser Leu Thr His Thr Cys Ser 
            100                 105                 110         


Cys Asn Ile Gly Thr Ile Leu Asn Gln Asn Lys Leu Cys Asp Ile Gln 
        115                 120                 125             


Gly Asp Thr Pro Cys Ser Leu Lys Cys Ala Glu Asn Glu Val Cys Thr 
    130                 135                 140                 


Leu Glu Gly Asn Tyr Tyr Thr Cys Lys Glu Asp Pro Ser Ser Asn Gly 
145                 150                 155                 160 


Gly Gly Asn Thr Val Asp Gln Ala Ser Ala Ala Ala Lys Gly Pro Ser 
                165                 170                 175     


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
            180                 185                 190         


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
        195                 200                 205             


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
    210                 215                 220                 


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
225                 230                 235                 240 


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
                245                 250                 255     


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
            260                 265                 270         


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
        275                 280                 285             


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
    290                 295                 300                 


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
305                 310                 315                 320 


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
                325                 330                 335     


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
            340                 345                 350         


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
        355                 360                 365             


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Phe Pro Ala Pro Ile 
    370                 375                 380                 


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
385                 390                 395                 400 


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
                405                 410                 415     


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
            420                 425                 430         


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
        435                 440                 445             


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
    450                 455                 460                 


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
465                 470                 475                 480 


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
                485                 490                 495     


Pro Gly Lys Ser Glu Lys Asp Glu Leu 
            500                 505 


<210>  39
<211>  410
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Malaria Immunoassemblin heavy chain fusion polypeptide

<400>  39

Pro Ser Asp Lys His Ile Glu Gln Tyr Leu Lys Lys Ile Gln Asn Ser 
1               5                   10                  15      


Leu Ser Thr Glu Trp Ser Pro Cys Ser Val Thr Cys Gly Asn Gly Ile 
            20                  25                  30          


Gln Val Arg Ile Lys Pro Gly Ser Ala Asn Lys Pro Lys Asp Glu Leu 
        35                  40                  45              


Asp Tyr Glu Asn Asp Ile Glu Lys Lys Ile Cys Lys Met Glu Lys Cys 
    50                  55                  60                  


Ser Ser Val Phe Asn Val Val Asn Ser Ser Ala Ala Ala Lys Gly Pro 
65                  70                  75                  80  


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
                85                  90                  95      


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
            100                 105                 110         


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
        115                 120                 125             


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
    130                 135                 140                 


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
145                 150                 155                 160 


His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
                165                 170                 175     


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
            180                 185                 190         


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
        195                 200                 205             


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
    210                 215                 220                 


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
225                 230                 235                 240 


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
                245                 250                 255     


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
            260                 265                 270         


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Phe Pro Ala Pro 
        275                 280                 285             


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
    290                 295                 300                 


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
305                 310                 315                 320 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
                325                 330                 335     


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
            340                 345                 350         


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
        355                 360                 365             


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
    370                 375                 380                 


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
385                 390                 395                 400 


Ser Pro Gly Lys Ser Glu Lys Asp Glu Leu 
                405                 410 


<210>  40
<211>  410
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Malaria Immunoassemblin heavy chain fusion polypeptide

<400>  40

Thr His Asp Thr Cys Asp Glu Trp Ser Glu Trp Ser Ala Cys Thr His 
1               5                   10                  15      


Gly Ile Ser Thr Arg Lys Cys Leu Ser Asp Ser Ser Ile Lys Asp Glu 
            20                  25                  30          


Thr Leu Val Cys Thr Lys Cys Asp Lys Trp Gly Glu Trp Ser Glu Cys 
        35                  40                  45              


Lys Asp Gly Arg Met His Arg Lys Val Leu Asn Cys Pro Phe Ile Lys 
    50                  55                  60                  


Glu Glu Gln Glu Cys Asp Val Asn Asn Glu Ala Ala Ala Lys Gly Pro 
65                  70                  75                  80  


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
                85                  90                  95      


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
            100                 105                 110         


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
        115                 120                 125             


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
    130                 135                 140                 


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
145                 150                 155                 160 


His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
                165                 170                 175     


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
            180                 185                 190         


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
        195                 200                 205             


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
    210                 215                 220                 


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
225                 230                 235                 240 


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
                245                 250                 255     


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
            260                 265                 270         


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Phe Pro Ala Pro 
        275                 280                 285             


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
    290                 295                 300                 


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
305                 310                 315                 320 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
                325                 330                 335     


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
            340                 345                 350         


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
        355                 360                 365             


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
    370                 375                 380                 


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
385                 390                 395                 400 


Ser Pro Gly Lys Ser Glu Lys Asp Glu Leu 
                405                 410 


<210>  41
<211>  619
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Malaria Immunoassemblin heavy chain fusion polypeptide

<400>  41

Pro Ser Asp Lys His Ile Glu Gln Tyr Leu Lys Lys Ile Gln Asn Ser 
1               5                   10                  15      


Leu Ser Thr Glu Trp Ser Pro Cys Ser Val Thr Cys Gly Asn Gly Ile 
            20                  25                  30          


Gln Val Arg Ile Lys Pro Gly Ser Ala Asn Lys Pro Lys Asp Glu Leu 
        35                  40                  45              


Asp Tyr Glu Asn Asp Ile Glu Lys Lys Ile Cys Lys Met Glu Lys Cys 
    50                  55                  60                  


Ser Ser Val Phe Asn Val Val Asn Ser Ser Ala Ala Val Ala Met Ala 
65                  70                  75                  80  


Glu Lys Thr Ala Ser Cys Gly Val Trp Asp Glu Trp Ser Pro Cys Ser 
                85                  90                  95      


Val Thr Cys Gly Lys Gly Thr Arg Ser Arg Lys Arg Glu Ile Leu His 
            100                 105                 110         


Glu Gly Cys Thr Ser Glu Leu Gln Glu Gln Cys Glu Glu Glu Arg Cys 
        115                 120                 125             


Leu Pro Lys Ala Ala Val Ala Met Ala Thr His Asp Thr Cys Asp Glu 
    130                 135                 140                 


Trp Ser Glu Trp Ser Ala Cys Thr His Gly Ile Ser Thr Arg Lys Cys 
145                 150                 155                 160 


Leu Ser Asp Ser Ser Ile Lys Asp Glu Thr Leu Val Cys Thr Lys Cys 
                165                 170                 175     


Asp Lys Trp Gly Glu Trp Ser Glu Cys Lys Asp Gly Arg Met His Arg 
            180                 185                 190         


Lys Val Leu Asn Cys Pro Phe Ile Lys Glu Glu Gln Glu Cys Asp Val 
        195                 200                 205             


Asn Asn Glu Ala Ala Val Ala Met Ala Phe Tyr Ser Glu Trp Gly Glu 
    210                 215                 220                 


Trp Ser Asn Cys Ala Met Asp Cys Asp His Pro Asp Asn Val Gln Ile 
225                 230                 235                 240 


Arg Glu Arg Glu Cys Ile His Pro Ser Gly Asp Cys Phe Lys Gly Asp 
                245                 250                 255     


Leu Lys Glu Ser Arg Pro Cys Ile Ile Pro Leu Pro Pro Cys Asn Glu 
            260                 265                 270         


Leu Phe Ser His Lys Asp Asn Ser Ala Phe Lys Ala Ala Ala Lys Gly 
        275                 280                 285             


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
    290                 295                 300                 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
305                 310                 315                 320 


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                325                 330                 335     


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            340                 345                 350         


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
        355                 360                 365             


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys 
    370                 375                 380                 


Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
385                 390                 395                 400 


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
                405                 410                 415     


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
            420                 425                 430         


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
        435                 440                 445             


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
    450                 455                 460                 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
465                 470                 475                 480 


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Phe Pro Ala 
                485                 490                 495     


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
            500                 505                 510         


Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
        515                 520                 525             


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
    530                 535                 540                 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
545                 550                 555                 560 


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
                565                 570                 575     


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
            580                 585                 590         


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
        595                 600                 605             


Leu Ser Pro Gly Lys Ser Glu Lys Asp Glu Leu 
    610                 615                 


<210>  42
<211>  665
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Malaria Immunoassemblin heavy chain fusion polypeptide

<400>  42

Ser Lys Glu Ile Val Lys Lys Tyr Asn Leu Asn Leu Arg Asn Ala Ile 
1               5                   10                  15      


Leu Asn Asn Asn Ser Gln Ile Glu Asn Glu Glu Asn Val Asn Thr Thr 
            20                  25                  30          


Ile Thr Gly Asn Asp Phe Ser Gly Gly Glu Phe Leu Trp Pro Gly Tyr 
        35                  40                  45              


Thr Glu Glu Leu Lys Ala Lys Lys Ala Ser Glu Asp Ala Glu Lys Ala 
    50                  55                  60                  


Ala Asn Asp Ala Glu Asn Ala Ser Lys Glu Ala Glu Glu Ala Ala Lys 
65                  70                  75                  80  


Glu Ala Val Asn Leu Lys Glu Ser Asp Lys Ser Tyr Thr Lys Ala Lys 
                85                  90                  95      


Glu Ala Ala Thr Ala Ala Ser Lys Ala Lys Lys Ala Val Glu Thr Ala 
            100                 105                 110         


Leu Lys Ala Lys Asp Asp Ala Glu Lys Ser Ser Lys Ala Asp Ser Ile 
        115                 120                 125             


Ser Thr Lys Thr Lys Glu Tyr Ala Glu Lys Ala Lys Asn Ala Tyr Glu 
    130                 135                 140                 


Lys Ala Lys Asn Ala Tyr Gln Lys Ala Asn Gln Ala Val Leu Lys Ala 
145                 150                 155                 160 


Lys Glu Ala Ser Ser Tyr Asp Tyr Ile Leu Gly Trp Glu Phe Gly Gly 
                165                 170                 175     


Gly Val Pro Glu His Lys Lys Glu Glu Asn Met Leu Ser His Leu Tyr 
            180                 185                 190         


Val Ser Ser Lys Asp Lys Glu Asn Ile Ala Lys Glu Asn Asp Asp Val 
        195                 200                 205             


Leu Asp Glu Lys Glu Glu Glu Ala Glu Glu Thr Glu Glu Glu Glu Leu 
    210                 215                 220                 


Glu Glu Lys Asn Glu Glu Glu Thr Glu Ser Glu Ile Ser Glu Asp Glu 
225                 230                 235                 240 


Glu Glu Glu Glu Glu Glu Glu Lys Glu Glu Glu Asn Asp Lys Lys Lys 
                245                 250                 255     


Glu Gln Glu Lys Glu Gln Ser Asn Glu Asn Asn Asp Gln Lys Lys Asp 
            260                 265                 270         


Met Glu Ala Gln Asn Leu Ile Ser Lys Asn Gln Asn Asn Asn Glu Lys 
        275                 280                 285             


Asn Val Lys Glu Ala Ala Glu Ser Ile Met Lys Thr Leu Ala Gly Leu 
    290                 295                 300                 


Ile Lys Gly Asn Asn Gln Ile Asp Ser Thr Leu Lys Asp Leu Val Glu 
305                 310                 315                 320 


Glu Leu Ser Lys Tyr Phe Lys Asn His Ala Ala Ala Lys Gly Pro Ser 
                325                 330                 335     


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
            340                 345                 350         


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
        355                 360                 365             


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
    370                 375                 380                 


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
385                 390                 395                 400 


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
                405                 410                 415     


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
            420                 425                 430         


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
        435                 440                 445             


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
    450                 455                 460                 


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
465                 470                 475                 480 


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
                485                 490                 495     


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
            500                 505                 510         


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
        515                 520                 525             


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Phe Pro Ala Pro Ile 
    530                 535                 540                 


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
545                 550                 555                 560 


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
                565                 570                 575     


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
            580                 585                 590         


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
        595                 600                 605             


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
    610                 615                 620                 


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
625                 630                 635                 640 


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
                645                 650                 655     


Pro Gly Lys Ser Glu Lys Asp Glu Leu 
            660                 665 


<210>  43
<211>  691
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Malaria Immunoassemblin heavy chain fusion polypeptide

<400>  43

Ser Lys Glu Ile Val Lys Lys Tyr Asn Leu Asn Leu Arg Asn Ala Ile 
1               5                   10                  15      


Leu Asn Asn Asn Ser Gln Ile Glu Asn Glu Glu Asn Asp Ile Lys Tyr 
            20                  25                  30          


Glu Leu Asn Glu Gln Asn Asp Glu Asn Val Asn Thr Pro Ile Val Gly 
        35                  40                  45              


Asn Met Glu Phe Gly Glu Gly Phe Ser Ala Asp Asp Gln Lys Asp Ile 
    50                  55                  60                  


Glu Ala Tyr Lys Lys Ala Lys Gln Ala Ser Gln Asp Ala Glu Gln Ala 
65                  70                  75                  80  


Ala Lys Asp Ala Glu Asn Ala Ala Lys Asp Ala Glu Glu Ala Ala Lys 
                85                  90                  95      


Asp Ala Glu Lys Leu Lys Glu Ser Asp Glu Ser Tyr Thr Lys Ala Lys 
            100                 105                 110         


Glu Ala Cys Thr Ala Ala Ser Lys Ala Lys Lys Ala Val Glu Thr Ala 
        115                 120                 125             


Leu Lys Ala Lys Asp Asp Ala Glu Thr Ala Leu Lys Thr Ser Glu Thr 
    130                 135                 140                 


Pro Glu Lys Pro Ser Arg Ile Asn Leu Phe Ser Arg Lys Thr Lys Glu 
145                 150                 155                 160 


Tyr Ala Glu Lys Ala Lys Asn Ala Tyr Glu Lys Ala Lys Asn Ala Tyr 
                165                 170                 175     


Gln Lys Ala Asn Gln Ala Val Leu Lys Ala Lys Glu Ala Ser Ser Tyr 
            180                 185                 190         


Asp Tyr Ile Leu Gly Trp Glu Phe Gly Gly Gly Val Pro Glu His Lys 
        195                 200                 205             


Lys Glu Glu Asn Met Leu Ser His Leu Tyr Val Ser Ser Lys Asp Lys 
    210                 215                 220                 


Glu Asn Ile Ala Lys Glu Asn Asp Asp Val Leu Asp Glu Lys Glu Glu 
225                 230                 235                 240 


Glu Ala Glu Glu Thr Glu Glu Glu Glu Leu Glu Glu Lys Asn Glu Glu 
                245                 250                 255     


Glu Thr Glu Ser Glu Ile Ser Glu Asp Glu Glu Glu Glu Glu Glu Glu 
            260                 265                 270         


Glu Lys Glu Glu Glu Asn Asp Lys Lys Lys Glu Gln Glu Lys Glu Gln 
        275                 280                 285             


Ser Asn Glu Asn Asn Asp Gln Lys Lys Asp Met Glu Ala Gln Asn Leu 
    290                 295                 300                 


Ile Ser Lys Asn Gln Asn Asn Asn Glu Lys Asn Val Lys Glu Ala Ala 
305                 310                 315                 320 


Glu Ser Ile Met Lys Thr Leu Ala Gly Leu Ile Lys Gly Asn Asn Gln 
                325                 330                 335     


Ile Asp Ser Thr Leu Lys Asp Leu Val Glu Glu Leu Ser Lys Tyr Phe 
            340                 345                 350         


Lys Asn His Ala Ala Ala Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
        355                 360                 365             


Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val 
    370                 375                 380                 


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
385                 390                 395                 400 


Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
                405                 410                 415     


Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 
            420                 425                 430         


Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys 
        435                 440                 445             


Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys 
    450                 455                 460                 


Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 
465                 470                 475                 480 


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                485                 490                 495     


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
            500                 505                 510         


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        515                 520                 525             


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    530                 535                 540                 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
545                 550                 555                 560 


Val Ser Asn Lys Ala Phe Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
                565                 570                 575     


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            580                 585                 590         


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        595                 600                 605             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    610                 615                 620                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
625                 630                 635                 640 


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                645                 650                 655     


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            660                 665                 670         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Ser Glu Lys 
        675                 680                 685             


Asp Glu Leu 
    690     


<210>  44
<211>  568
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Malaria Immunoassemblin heavy chain fusion polypeptide

<400>  44

Asn Gly Leu Thr Gly Ala Thr Glu Asn Ile Ala Gln Val Val Gln Ala 
1               5                   10                  15      


Asn Ser Glu Thr Asn Lys Asn Pro Thr Ser His Ser Asn Ser Thr Thr 
            20                  25                  30          


Thr Ser Leu Asn Asn Asn Ile Leu Gly Trp Glu Phe Gly Gly Gly Ala 
        35                  40                  45              


Pro Gln Asn Gly Ala Ala Glu Asp Lys Lys Thr Glu Tyr Leu Leu Glu 
    50                  55                  60                  


Gln Ile Lys Ile Pro Ser Trp Asp Arg Asn Asn Ile Pro Asp Glu Asn 
65                  70                  75                  80  


Glu Gln Val Ile Glu Asp Pro Gln Glu Asp Asn Lys Asp Glu Asp Glu 
                85                  90                  95      


Asp Glu Glu Thr Glu Thr Glu Asn Leu Glu Thr Glu Asp Asp Asn Asn 
            100                 105                 110         


Glu Glu Ile Glu Glu Asn Glu Glu Asp Asp Ile Asp Glu Glu Ser Val 
        115                 120                 125             


Glu Glu Lys Glu Glu Glu Glu Glu Lys Lys Glu Glu Glu Glu Lys Lys 
    130                 135                 140                 


Glu Glu Lys Lys Glu Glu Lys Lys Pro Asp Asn Glu Ile Thr Asn Glu 
145                 150                 155                 160 


Val Lys Glu Glu Gln Lys Tyr Ser Ser Pro Ser Asp Ile Asn Ala Gln 
                165                 170                 175     


Asn Leu Ile Ser Asn Lys Asn Lys Lys Asn Asp Glu Thr Lys Lys Thr 
            180                 185                 190         


Ala Glu Asn Ile Val Lys Thr Leu Val Gly Leu Phe Asn Glu Lys Asn 
        195                 200                 205             


Glu Ile Asp Ser Thr Ile Asn Asn Leu Val Gln Glu Met Ile His Leu 
    210                 215                 220                 


Phe Ser Ser Lys Ser Arg Trp Ser Ala Ala Ala Lys Gly Pro Ser Val 
225                 230                 235                 240 


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
                245                 250                 255     


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
            260                 265                 270         


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
        275                 280                 285             


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
    290                 295                 300                 


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
305                 310                 315                 320 


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
                325                 330                 335     


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
            340                 345                 350         


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
        355                 360                 365             


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
    370                 375                 380                 


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
385                 390                 395                 400 


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
                405                 410                 415     


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
            420                 425                 430         


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Phe Pro Ala Pro Ile Glu 
        435                 440                 445             


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
    450                 455                 460                 


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
465                 470                 475                 480 


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
                485                 490                 495     


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
            500                 505                 510         


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
        515                 520                 525             


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
    530                 535                 540                 


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
545                 550                 555                 560 


Gly Lys Ser Glu Lys Asp Glu Leu 
                565             


<210>  45
<211>  510
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Malaria Immunoassemblin heavy chain fusion polypeptide

<400>  45

Ser Glu Thr Asp Thr Gln Ser Lys Asn Glu Gln Glu Ile Ser Thr Gln 
1               5                   10                  15      


Gly Gln Glu Val Gln Lys Pro Ala Gln Gly Gly Glu Ser Thr Phe Gln 
            20                  25                  30          


Lys Asp Leu Asp Lys Lys Leu Tyr Asn Leu Gly Asp Val Phe Asn His 
        35                  40                  45              


Val Val Asp Ile Ser Asn Lys Glu Asn Lys Ile Asn Leu Asp Glu His 
    50                  55                  60                  


Asp Lys Lys Tyr Thr Asp Phe Lys Lys Glu Tyr Glu Asp Phe Val Leu 
65                  70                  75                  80  


Asn Ser Lys Glu Tyr Asp Ile Ile Lys Asn Leu Ile Ile Met Phe Gly 
                85                  90                  95      


Gln Glu Asp Asn Lys Ala Lys Asn Gly Lys Thr Asp Ile Val Ser Glu 
            100                 105                 110         


Ala Lys His Ile Thr Glu Ile Phe Ile Lys Leu Phe Lys Asp Lys Glu 
        115                 120                 125             


Tyr His Glu Gln Phe Lys Asn Tyr Ile Tyr Gly Val Tyr Ser Tyr Ala 
    130                 135                 140                 


Lys Gln Asn Ser His Leu Ser Glu Lys Lys Ile Lys Gln Glu Glu Glu 
145                 150                 155                 160 


Tyr Lys Lys Phe Leu Glu Tyr Ser Phe Asn Leu Leu Asn Thr Ala Ala 
                165                 170                 175     


Ala Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 
            180                 185                 190         


Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
        195                 200                 205             


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
    210                 215                 220                 


His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
225                 230                 235                 240 


Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 
                245                 250                 255     


Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val 
            260                 265                 270         


Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
        275                 280                 285             


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
    290                 295                 300                 


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
305                 310                 315                 320 


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
                325                 330                 335     


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
            340                 345                 350         


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
        355                 360                 365             


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
    370                 375                 380                 


Phe Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
385                 390                 395                 400 


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
                405                 410                 415     


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
            420                 425                 430         


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
        435                 440                 445             


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
    450                 455                 460                 


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
465                 470                 475                 480 


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
                485                 490                 495     


Ser Leu Ser Leu Ser Pro Gly Lys Ser Glu Lys Asp Glu Leu 
            500                 505                 510 


<210>  46
<211>  454
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Malaria Immunoassemblin heavy chain fusion polypeptide

<400>  46

Glu Lys Thr Asn Lys Gly Thr Gly Ser Gly Val Ser Ser Lys Lys Lys 
1               5                   10                  15      


Asn Lys Lys Gly Ser Gly Glu Pro Leu Ile Asp Val His Asp Leu Ile 
            20                  25                  30          


Ser Asp Met Ile Lys Lys Glu Glu Glu Leu Val Glu Val Asn Lys Arg 
        35                  40                  45              


Lys Ser Lys Tyr Lys Leu Ala Thr Ser Asn Thr Glu Lys Gly Arg His 
    50                  55                  60                  


Pro Phe Lys Ile Gly Ser Ser Asp Pro Ala Asp Asn Ala Asn Pro Asp 
65                  70                  75                  80  


Ala Asp Ser Glu Ser Asn Gly Glu Pro Asn Ala Asp Pro Gln Val Thr 
                85                  90                  95      


Ala Gln Asp Val Thr Pro Glu Gln Pro Gln Gly Asp Asp Asn Asn Leu 
            100                 105                 110         


Val Ser Gly Pro Glu His Ala Ala Ala Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Ala Phe Pro Ala Pro Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445             


Ser Glu Lys Asp Glu Leu 
    450                 


<210>  47
<211>  619
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Malaria Immunoassemblin heavy chain fusion polypeptide

<400>  47

Asp Lys Asn Ser Val Asp Thr Asn Thr Lys Val Trp Glu Cys Lys Lys 
1               5                   10                  15      


Pro Tyr Lys Leu Ser Thr Lys Asp Val Cys Val Pro Pro Arg Arg Gln 
            20                  25                  30          


Glu Leu Cys Leu Gly Asn Ile Asp Arg Ile Tyr Asp Lys Asn Leu Leu 
        35                  40                  45              


Met Ile Lys Glu His Ile Leu Ala Ile Ala Ile Tyr Glu Ser Arg Ile 
    50                  55                  60                  


Leu Lys Arg Lys Tyr Lys Asn Lys Asp Asp Lys Glu Val Cys Lys Ile 
65                  70                  75                  80  


Ile Asn Lys Ala Phe Ala Asp Ile Arg Asp Ile Ile Gly Gly Thr Asp 
                85                  90                  95      


Tyr Trp Asn Asp Leu Ser Asn Arg Lys Leu Val Gly Lys Ile Asn Thr 
            100                 105                 110         


Asn Ser Asn Tyr Val His Arg Asn Lys Gln Asn Asp Lys Leu Phe Arg 
        115                 120                 125             


Asp Glu Trp Trp Lys Val Ile Lys Lys Asp Val Trp Asn Val Ile Ser 
    130                 135                 140                 


Trp Val Phe Lys Asp Lys Thr Val Cys Lys Glu Asp Asp Ile Glu Asn 
145                 150                 155                 160 


Ile Pro Gln Phe Phe Arg Trp Phe Ser Glu Trp Gly Asp Asp Tyr Cys 
                165                 170                 175     


Gln Asp Lys Thr Lys Met Ile Glu Thr Leu Lys Val Glu Cys Lys Glu 
            180                 185                 190         


Lys Pro Cys Glu Asp Asp Asn Cys Lys Arg Lys Cys Asn Ser Tyr Lys 
        195                 200                 205             


Glu Trp Ile Ser Lys Lys Lys Glu Glu Tyr Asn Lys Gln Ala Lys Gln 
    210                 215                 220                 


Tyr Gln Glu Tyr Gln Lys Gly Asn Asn Tyr Lys Met Tyr Ser Glu Phe 
225                 230                 235                 240 


Lys Ser Ile Lys Pro Glu Val Tyr Leu Lys Lys Tyr Ser Glu Lys Cys 
                245                 250                 255     


Ser Asn Leu Asn Phe Glu Asp Glu Phe Lys Glu Glu Leu His Ser Asp 
            260                 265                 270         


Tyr Lys Asn Lys Cys Thr Met Cys Pro Glu Val Ala Ala Ala Lys Gly 
        275                 280                 285             


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
    290                 295                 300                 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
305                 310                 315                 320 


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                325                 330                 335     


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            340                 345                 350         


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
        355                 360                 365             


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys 
    370                 375                 380                 


Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
385                 390                 395                 400 


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
                405                 410                 415     


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
            420                 425                 430         


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
        435                 440                 445             


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
    450                 455                 460                 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
465                 470                 475                 480 


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Phe Pro Ala 
                485                 490                 495     


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
            500                 505                 510         


Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
        515                 520                 525             


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
    530                 535                 540                 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
545                 550                 555                 560 


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
                565                 570                 575     


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
            580                 585                 590         


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
        595                 600                 605             


Leu Ser Pro Gly Lys Ser Glu Lys Asp Glu Leu 
    610                 615                 


<210>  48
<211>  786
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Malaria Immunoassemblin heavy chain fusion polypeptide

<400>  48

Ile Glu Ile Val Glu Arg Ser Asn Tyr Met Gly Asn Pro Trp Thr Glu 
1               5                   10                  15      


Tyr Met Ala Lys Tyr Asp Ile Glu Glu Val His Gly Ser Gly Ile Arg 
            20                  25                  30          


Val Asp Leu Gly Glu Asp Ala Glu Val Ala Gly Thr Gln Tyr Arg Leu 
        35                  40                  45              


Pro Ser Gly Lys Cys Pro Val Phe Gly Lys Gly Ile Ile Ile Glu Asn 
    50                  55                  60                  


Ser Asn Thr Ala Phe Leu Thr Pro Val Ala Thr Gly Asn Gln Tyr Leu 
65                  70                  75                  80  


Lys Asp Gly Gly Phe Ala Phe Pro Pro Thr Glu Pro Leu Met Ser Pro 
                85                  90                  95      


Met Thr Leu Asp Glu Met Arg His Phe Tyr Lys Asp Asn Lys Tyr Val 
            100                 105                 110         


Lys Asn Leu Asp Glu Leu Thr Leu Cys Ser Arg His Ala Gly Asn Met 
        115                 120                 125             


Ile Pro Asp Asn Asp Lys Asn Ser Asn Tyr Lys Tyr Pro Ala Val Tyr 
    130                 135                 140                 


Asp Asp Lys Asp Lys Lys Cys His Ile Leu Tyr Ile Ala Ala Gln Glu 
145                 150                 155                 160 


Asn Asn Gly Pro Arg Tyr Cys Asn Lys Asp Glu Ser Lys Arg Asn Ser 
                165                 170                 175     


Met Phe Cys Phe Arg Pro Ala Lys Asp Ile Ser Phe Gln Asn Tyr Ala 
            180                 185                 190         


Tyr Leu Ser Lys Asn Val Val Asp Asn Trp Glu Lys Val Cys Pro Arg 
        195                 200                 205             


Lys Asn Leu Gln Asn Ala Lys Phe Gly Leu Trp Val Asp Gly Asn Cys 
    210                 215                 220                 


Glu Asp Ile Pro His Val Asn Glu Phe Pro Ala Ile Asp Leu Phe Glu 
225                 230                 235                 240 


Cys Asn Lys Leu Val Phe Glu Leu Ser Ala Ser Asp Gln Pro Lys Gln 
                245                 250                 255     


Tyr Glu Gln His Leu Thr Asp Tyr Glu Lys Ile Lys Glu Gly Phe Lys 
            260                 265                 270         


Asn Lys Asn Ala Ala Met Ile Lys Ser Ala Phe Leu Pro Thr Gly Ala 
        275                 280                 285             


Phe Lys Ala Asp Arg Tyr Lys Ser His Gly Lys Gly Tyr Asn Trp Gly 
    290                 295                 300                 


Asn Tyr Asn Thr Glu Thr Gln Lys Cys Glu Ile Phe Asn Val Lys Pro 
305                 310                 315                 320 


Thr Cys Leu Ile Asn Asn Ala Ala Tyr Ile Ala Thr Thr Ala Leu Ser 
                325                 330                 335     


His Pro Ile Glu Val Glu Asn Asn Phe Pro Cys Ser Leu Tyr Lys Asp 
            340                 345                 350         


Glu Ile Met Lys Glu Ile Glu Arg Glu Ser Lys Arg Ile Lys Leu Asn 
        355                 360                 365             


Asp Asn Asp Asp Glu Gly Asn Lys Lys Ile Ile Ala Pro Arg Ile Phe 
    370                 375                 380                 


Ile Ser Asp Asp Lys Asp Ser Leu Lys Cys Pro Cys Asp Pro Glu Met 
385                 390                 395                 400 


Val Ser Asn Ser Ala Cys Arg Phe Phe Val Cys Lys Cys Val Glu Arg 
                405                 410                 415     


Arg Ala Glu Val Thr Ser Asn Asn Glu Val Val Val Lys Glu Glu Tyr 
            420                 425                 430         


Lys Asp Glu Tyr Ala Asp Ile Pro Glu His Lys Pro Thr Tyr Asp Lys 
        435                 440                 445             


Met Lys Ala Ala Ala Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser 
    450                 455                 460                 


Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys 
465                 470                 475                 480 


Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
                485                 490                 495     


Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
            500                 505                 510         


Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr 
        515                 520                 525             


Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val 
    530                 535                 540                 


Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro 
545                 550                 555                 560 


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
                565                 570                 575     


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
            580                 585                 590         


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
        595                 600                 605             


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
    610                 615                 620                 


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
625                 630                 635                 640 


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
                645                 650                 655     


Ser Asn Lys Ala Phe Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
            660                 665                 670         


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
        675                 680                 685             


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
    690                 695                 700                 


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
705                 710                 715                 720 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
                725                 730                 735     


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
            740                 745                 750         


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
        755                 760                 765             


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Ser Glu Lys Asp 
    770                 775                 780                 


Glu Leu 
785     


<210>  49
<211>  384
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Malaria Immunoassemblin heavy chain fusion polypeptide

<400>  49

Met Asp Ile Thr Gln Gln Ala Lys Asp Ile Gly Ala Gly Pro Val Ala 
1               5                   10                  15      


Ser Cys Phe Thr Thr Arg Met Ser Pro Pro Gln Gln Ile Cys Leu Asn 
            20                  25                  30          


Ser Val Val Asn Thr Ala Leu Ser Thr Ser Thr Gln Ser Ala Met Lys 
        35                  40                  45              


Ala Ala Ala Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
    50                  55                  60                  


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
65                  70                  75                  80  


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
                85                  90                  95      


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
            100                 105                 110         


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
        115                 120                 125             


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
    130                 135                 140                 


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
145                 150                 155                 160 


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
                165                 170                 175     


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
            180                 185                 190         


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
        195                 200                 205             


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
    210                 215                 220                 


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
225                 230                 235                 240 


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
                245                 250                 255     


Lys Ala Phe Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
            260                 265                 270         


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
        275                 280                 285             


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
    290                 295                 300                 


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
305                 310                 315                 320 


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
                325                 330                 335     


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
            340                 345                 350         


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
        355                 360                 365             


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Ser Glu Lys Asp Glu Leu 
    370                 375                 380                 


<210>  50
<211>  103
<212>  PRT
<213>  Homo sapiens

<400>  50

Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
1               5                   10                  15      


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
            20                  25                  30          


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
        35                  40                  45              


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
    50                  55                  60                  


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
65                  70                  75                  80  


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
                85                  90                  95      


Ser Phe Asn Arg Gly Glu Cys 
            100             


<210>  51
<211>  200
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MIA-fusion polypeptides

<400>  51

Ile Ser Gln His Gln Cys Val Lys Lys Gln Cys Pro Glu Asn Ser Gly 
1               5                   10                  15      


Cys Phe Arg His Leu Asp Glu Arg Glu Glu Cys Lys Cys Leu Leu Asn 
            20                  25                  30          


Tyr Lys Gln Glu Gly Asp Lys Cys Val Glu Asn Pro Asn Pro Thr Cys 
        35                  40                  45              


Asn Glu Asn Asn Gly Gly Cys Asp Ala Asp Ala Thr Cys Thr Glu Glu 
    50                  55                  60                  


Asp Ser Gly Ser Ser Arg Lys Lys Ile Thr Cys Glu Cys Thr Lys Pro 
65                  70                  75                  80  


Asp Ser Tyr Pro Leu Phe Asp Gly Ile Phe Cys Ser Ser Ser Asn Ala 
                85                  90                  95      


Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys 
            100                 105                 110         


Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg 
        115                 120                 125             


Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn 
    130                 135                 140                 


Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser 
145                 150                 155                 160 


Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys 
                165                 170                 175     


Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr 
            180                 185                 190         


Lys Ser Phe Asn Arg Gly Glu Cys 
        195                 200 


<210>  52
<211>  503
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MIA-fusion polypeptides

<400>  52

Ile Ser Gln His Gln Cys Val Lys Lys Gln Cys Pro Glu Asn Ser Gly 
1               5                   10                  15      


Cys Phe Arg His Leu Asp Glu Arg Glu Glu Cys Lys Cys Leu Leu Asn 
            20                  25                  30          


Tyr Lys Gln Glu Gly Asp Lys Cys Val Glu Asn Pro Asn Pro Thr Cys 
        35                  40                  45              


Asn Glu Asn Asn Gly Gly Cys Asp Ala Asp Ala Thr Cys Thr Glu Glu 
    50                  55                  60                  


Asp Ser Gly Ser Ser Arg Lys Lys Ile Thr Cys Glu Cys Thr Lys Pro 
65                  70                  75                  80  


Asp Ser Tyr Pro Leu Phe Asp Gly Ile Phe Cys Ser Ser Ser Asn Ala 
                85                  90                  95      


Ala Val Ala Met Ala Ile Ser Gln His Gln Cys Val Lys Lys Gln Cys 
            100                 105                 110         


Pro Glu Asn Ser Gly Cys Phe Arg His Leu Asp Glu Arg Glu Glu Cys 
        115                 120                 125             


Lys Cys Leu Leu Asn Tyr Lys Gln Glu Gly Asp Lys Cys Val Glu Asn 
    130                 135                 140                 


Pro Asn Pro Thr Cys Asn Glu Asn Asn Gly Gly Cys Asp Ala Asp Ala 
145                 150                 155                 160 


Lys Cys Thr Glu Glu Asp Ser Gly Ser Asn Gly Lys Lys Ile Thr Cys 
                165                 170                 175     


Glu Cys Thr Lys Pro Asp Ser Tyr Pro Leu Phe Asp Gly Ile Phe Cys 
            180                 185                 190         


Ser Ser Ser Asn Ala Ala Val Ala Met Ala Ile Ser Gln His Gln Cys 
        195                 200                 205             


Val Lys Lys Gln Cys Pro Gln Asn Ser Gly Cys Phe Arg His Leu Asp 
    210                 215                 220                 


Glu Arg Glu Glu Cys Lys Cys Leu Leu Asn Tyr Lys Gln Glu Gly Asp 
225                 230                 235                 240 


Lys Cys Val Glu Asn Pro Asn Pro Thr Cys Asn Glu Asn Asn Gly Gly 
                245                 250                 255     


Cys Asp Ala Asp Ala Lys Cys Thr Glu Glu Asp Ser Gly Ser Asn Gly 
            260                 265                 270         


Lys Lys Ile Thr Cys Glu Cys Thr Lys Pro Asp Ser Tyr Pro Leu Phe 
        275                 280                 285             


Asp Gly Ile Phe Cys Ser Ser Ser Asn Ala Ala Val Ala Met Ala Ile 
    290                 295                 300                 


Ser Gln His Gln Cys Val Lys Lys Gln Cys Pro Gln Asn Ser Gly Cys 
305                 310                 315                 320 


Phe Arg His Leu Asp Glu Arg Glu Glu Cys Lys Cys Leu Leu Asn Tyr 
                325                 330                 335     


Lys Gln Glu Gly Asp Lys Cys Val Glu Asn Pro Asn Pro Thr Cys Asn 
            340                 345                 350         


Glu Asn Asn Gly Gly Cys Asp Ala Asp Ala Lys Cys Thr Glu Glu Asp 
        355                 360                 365             


Ser Gly Ser Asn Gly Lys Lys Ile Thr Cys Glu Cys Thr Lys Pro Asp 
    370                 375                 380                 


Ser Tyr Pro Phe Phe Asp Gly Ile Phe Cys Ser Ser Ser Asn Ala Ala 
385                 390                 395                 400 


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
                405                 410                 415     


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
            420                 425                 430         


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
        435                 440                 445             


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
    450                 455                 460                 


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
465                 470                 475                 480 


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
                485                 490                 495     


Ser Phe Asn Arg Gly Glu Cys 
            500             


<210>  53
<211>  274
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MIA-fusion polypeptides

<400>  53

Val Thr Val Asp Thr Val Cys Lys Arg Gly Phe Leu Ile Gln Met Ser 
1               5                   10                  15      


Gly His Leu Glu Cys Lys Cys Glu Asn Asp Leu Val Leu Val Asn Glu 
            20                  25                  30          


Glu Thr Cys Glu Glu Lys Val Leu Lys Cys Asp Glu Lys Thr Val Asn 
        35                  40                  45              


Lys Pro Cys Gly Asp Phe Ser Lys Cys Ile Lys Ile Asp Gly Asn Pro 
    50                  55                  60                  


Val Ser Tyr Ala Cys Lys Cys Asn Leu Gly Tyr Asp Met Val Asn Asn 
65                  70                  75                  80  


Val Cys Ile Pro Asn Glu Cys Lys Asn Val Ala Cys Gly Asn Gly Lys 
                85                  90                  95      


Cys Ile Leu Asp Thr Ser Asn Pro Val Lys Thr Gly Val Cys Ser Cys 
            100                 105                 110         


Asn Ile Gly Lys Val Pro Asn Val Gln Asp Gln Lys Cys Ser Lys Asp 
        115                 120                 125             


Gly Glu Thr Lys Cys Ser Leu Lys Cys Leu Lys Glu Asn Glu Ala Cys 
    130                 135                 140                 


Lys Ala Val Asp Gly Ile Tyr Lys Cys Asp Cys Lys Asp Gly Phe Ile 
145                 150                 155                 160 


Ile Asp Asn Glu Ala Ser Ile Cys Thr Ala Ala Ala Pro Ser Val Phe 
                165                 170                 175     


Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val 
            180                 185                 190         


Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp 
        195                 200                 205             


Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr 
    210                 215                 220                 


Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr 
225                 230                 235                 240 


Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val 
                245                 250                 255     


Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly 
            260                 265                 270         


Glu Cys 
        


<210>  54
<211>  274
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MIA-fusion polypeptides

<400>  54

Val Thr Val Asp Thr Val Cys Lys Arg Gly Phe Leu Ile Gln Met Ser 
1               5                   10                  15      


Gly His Leu Glu Cys Lys Cys Glu Asn Asp Thr Val Leu Val Asn Glu 
            20                  25                  30          


Glu Thr Cys Glu Glu Lys Val Leu Lys Cys Asp Glu Lys Thr Val Asn 
        35                  40                  45              


Lys Pro Cys Gly Asp Phe Ser Lys Cys Ile Lys Ile Asp Gly Asn Pro 
    50                  55                  60                  


Val Ser Tyr Ala Cys Lys Cys Asn Leu Gly Tyr Asp Met Val Asn Asn 
65                  70                  75                  80  


Val Cys Ile Pro Asn Glu Cys Lys Asn Val Thr Cys Gly Asn Gly Lys 
                85                  90                  95      


Cys Ile Leu Asp Thr Ser Asn Pro Val Lys Thr Gly Val Cys Ser Cys 
            100                 105                 110         


Asn Ile Gly Lys Val Pro Asn Val Gln Asp Gln Lys Cys Ser Lys Asp 
        115                 120                 125             


Gly Glu Thr Lys Cys Ser Leu Lys Cys Leu Lys Glu Asn Glu Thr Cys 
    130                 135                 140                 


Lys Ala Val Asp Gly Ile Tyr Lys Cys Asp Cys Lys Asp Gly Phe Ile 
145                 150                 155                 160 


Ile Asp Asn Glu Ala Ser Ile Cys Thr Ala Ala Ala Pro Ser Val Phe 
                165                 170                 175     


Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val 
            180                 185                 190         


Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp 
        195                 200                 205             


Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr 
    210                 215                 220                 


Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr 
225                 230                 235                 240 


Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val 
                245                 250                 255     


Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly 
            260                 265                 270         


Glu Cys 
        


<210>  55
<211>  274
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MIA-fusion polypeptides

<400>  55

Val Thr Glu Asn Thr Ile Cys Lys Tyr Gly Tyr Leu Ile Gln Met Ser 
1               5                   10                  15      


Asn His Tyr Glu Cys Lys Cys Ile Glu Gly Tyr Val Leu Ile Asn Glu 
            20                  25                  30          


Asp Thr Cys Gly Lys Lys Val Val Cys Asp Lys Val Glu Asn Ser Phe 
        35                  40                  45              


Lys Ala Cys Asp Glu Tyr Ala Tyr Cys Phe Asp Leu Gly Asn Lys Asn 
    50                  55                  60                  


Asn Glu Lys Gln Ile Lys Cys Met Cys Arg Thr Glu Tyr Thr Leu Thr 
65                  70                  75                  80  


Ala Gly Val Cys Val Pro Asn Val Cys Arg Asp Lys Val Cys Gly Lys 
                85                  90                  95      


Gly Lys Cys Ile Val Asp Pro Ala Asn Ser Leu Thr His Thr Cys Ser 
            100                 105                 110         


Cys Asn Ile Gly Thr Ile Leu Asn Gln Asn Lys Leu Cys Asp Ile Gln 
        115                 120                 125             


Gly Asp Thr Pro Cys Ser Leu Lys Cys Ala Glu Asn Glu Val Cys Thr 
    130                 135                 140                 


Leu Glu Gly Asn Tyr Tyr Thr Cys Lys Glu Asp Pro Ser Ser Asn Gly 
145                 150                 155                 160 


Gly Gly Asn Thr Val Asp Gln Ala Ser Ala Ala Ala Pro Ser Val Phe 
                165                 170                 175     


Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val 
            180                 185                 190         


Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp 
        195                 200                 205             


Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr 
    210                 215                 220                 


Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr 
225                 230                 235                 240 


Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val 
                245                 250                 255     


Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly 
            260                 265                 270         


Glu Cys 
        


<210>  56
<211>  179
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MIA-fusion polypeptides

<400>  56

Pro Ser Asp Lys His Ile Glu Gln Tyr Leu Lys Lys Ile Gln Asn Ser 
1               5                   10                  15      


Leu Ser Thr Glu Trp Ser Pro Cys Ser Val Thr Cys Gly Asn Gly Ile 
            20                  25                  30          


Gln Val Arg Ile Lys Pro Gly Ser Ala Asn Lys Pro Lys Asp Glu Leu 
        35                  40                  45              


Asp Tyr Glu Asn Asp Ile Glu Lys Lys Ile Cys Lys Met Glu Lys Cys 
    50                  55                  60                  


Ser Ser Val Phe Asn Val Val Asn Ser Ser Ala Ala Ala Pro Ser Val 
65                  70                  75                  80  


Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser 
                85                  90                  95      


Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln 
            100                 105                 110         


Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val 
        115                 120                 125             


Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu 
    130                 135                 140                 


Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu 
145                 150                 155                 160 


Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg 
                165                 170                 175     


Gly Glu Cys 
            


<210>  57
<211>  179
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MIA-fusion polypeptides

<400>  57

Thr His Asp Thr Cys Asp Glu Trp Ser Glu Trp Ser Ala Cys Thr His 
1               5                   10                  15      


Gly Ile Ser Thr Arg Lys Cys Leu Ser Asp Ser Ser Ile Lys Asp Glu 
            20                  25                  30          


Thr Leu Val Cys Thr Lys Cys Asp Lys Trp Gly Glu Trp Ser Glu Cys 
        35                  40                  45              


Lys Asp Gly Arg Met His Arg Lys Val Leu Asn Cys Pro Phe Ile Lys 
    50                  55                  60                  


Glu Glu Gln Glu Cys Asp Val Asn Asn Glu Ala Ala Ala Pro Ser Val 
65                  70                  75                  80  


Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser 
                85                  90                  95      


Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln 
            100                 105                 110         


Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val 
        115                 120                 125             


Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu 
    130                 135                 140                 


Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu 
145                 150                 155                 160 


Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg 
                165                 170                 175     


Gly Glu Cys 
            


<210>  58
<211>  388
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MIA-fusion polypeptides

<400>  58

Pro Ser Asp Lys His Ile Glu Gln Tyr Leu Lys Lys Ile Gln Asn Ser 
1               5                   10                  15      


Leu Ser Thr Glu Trp Ser Pro Cys Ser Val Thr Cys Gly Asn Gly Ile 
            20                  25                  30          


Gln Val Arg Ile Lys Pro Gly Ser Ala Asn Lys Pro Lys Asp Glu Leu 
        35                  40                  45              


Asp Tyr Glu Asn Asp Ile Glu Lys Lys Ile Cys Lys Met Glu Lys Cys 
    50                  55                  60                  


Ser Ser Val Phe Asn Val Val Asn Ser Ser Ala Ala Val Ala Met Ala 
65                  70                  75                  80  


Glu Lys Thr Ala Ser Cys Gly Val Trp Asp Glu Trp Ser Pro Cys Ser 
                85                  90                  95      


Val Thr Cys Gly Lys Gly Thr Arg Ser Arg Lys Arg Glu Ile Leu His 
            100                 105                 110         


Glu Gly Cys Thr Ser Glu Leu Gln Glu Gln Cys Glu Glu Glu Arg Cys 
        115                 120                 125             


Leu Pro Lys Ala Ala Val Ala Met Ala Thr His Asp Thr Cys Asp Glu 
    130                 135                 140                 


Trp Ser Glu Trp Ser Ala Cys Thr His Gly Ile Ser Thr Arg Lys Cys 
145                 150                 155                 160 


Leu Ser Asp Ser Ser Ile Lys Asp Glu Thr Leu Val Cys Thr Lys Cys 
                165                 170                 175     


Asp Lys Trp Gly Glu Trp Ser Glu Cys Lys Asp Gly Arg Met His Arg 
            180                 185                 190         


Lys Val Leu Asn Cys Pro Phe Ile Lys Glu Glu Gln Glu Cys Asp Val 
        195                 200                 205             


Asn Asn Glu Ala Ala Val Ala Met Ala Phe Tyr Ser Glu Trp Gly Glu 
    210                 215                 220                 


Trp Ser Asn Cys Ala Met Asp Cys Asp His Pro Asp Asn Val Gln Ile 
225                 230                 235                 240 


Arg Glu Arg Glu Cys Ile His Pro Ser Gly Asp Cys Phe Lys Gly Asp 
                245                 250                 255     


Leu Lys Glu Ser Arg Pro Cys Ile Ile Pro Leu Pro Pro Cys Asn Glu 
            260                 265                 270         


Leu Phe Ser His Lys Asp Asn Ser Ala Phe Lys Ala Ala Ala Pro Ser 
        275                 280                 285             


Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala 
    290                 295                 300                 


Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val 
305                 310                 315                 320 


Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser 
                325                 330                 335     


Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr 
            340                 345                 350         


Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys 
        355                 360                 365             


Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn 
    370                 375                 380                 


Arg Gly Glu Cys 
385             


<210>  59
<211>  434
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MIA-fusion polypeptides

<400>  59

Ser Lys Glu Ile Val Lys Lys Tyr Asn Leu Asn Leu Arg Asn Ala Ile 
1               5                   10                  15      


Leu Asn Asn Asn Ser Gln Ile Glu Asn Glu Glu Asn Val Asn Thr Thr 
            20                  25                  30          


Ile Thr Gly Asn Asp Phe Ser Gly Gly Glu Phe Leu Trp Pro Gly Tyr 
        35                  40                  45              


Thr Glu Glu Leu Lys Ala Lys Lys Ala Ser Glu Asp Ala Glu Lys Ala 
    50                  55                  60                  


Ala Asn Asp Ala Glu Asn Ala Ser Lys Glu Ala Glu Glu Ala Ala Lys 
65                  70                  75                  80  


Glu Ala Val Asn Leu Lys Glu Ser Asp Lys Ser Tyr Thr Lys Ala Lys 
                85                  90                  95      


Glu Ala Ala Thr Ala Ala Ser Lys Ala Lys Lys Ala Val Glu Thr Ala 
            100                 105                 110         


Leu Lys Ala Lys Asp Asp Ala Glu Lys Ser Ser Lys Ala Asp Ser Ile 
        115                 120                 125             


Ser Thr Lys Thr Lys Glu Tyr Ala Glu Lys Ala Lys Asn Ala Tyr Glu 
    130                 135                 140                 


Lys Ala Lys Asn Ala Tyr Gln Lys Ala Asn Gln Ala Val Leu Lys Ala 
145                 150                 155                 160 


Lys Glu Ala Ser Ser Tyr Asp Tyr Ile Leu Gly Trp Glu Phe Gly Gly 
                165                 170                 175     


Gly Val Pro Glu His Lys Lys Glu Glu Asn Met Leu Ser His Leu Tyr 
            180                 185                 190         


Val Ser Ser Lys Asp Lys Glu Asn Ile Ala Lys Glu Asn Asp Asp Val 
        195                 200                 205             


Leu Asp Glu Lys Glu Glu Glu Ala Glu Glu Thr Glu Glu Glu Glu Leu 
    210                 215                 220                 


Glu Glu Lys Asn Glu Glu Glu Thr Glu Ser Glu Ile Ser Glu Asp Glu 
225                 230                 235                 240 


Glu Glu Glu Glu Glu Glu Glu Lys Glu Glu Glu Asn Asp Lys Lys Lys 
                245                 250                 255     


Glu Gln Glu Lys Glu Gln Ser Asn Glu Asn Asn Asp Gln Lys Lys Asp 
            260                 265                 270         


Met Glu Ala Gln Asn Leu Ile Ser Lys Asn Gln Asn Asn Asn Glu Lys 
        275                 280                 285             


Asn Val Lys Glu Ala Ala Glu Ser Ile Met Lys Thr Leu Ala Gly Leu 
    290                 295                 300                 


Ile Lys Gly Asn Asn Gln Ile Asp Ser Thr Leu Lys Asp Leu Val Glu 
305                 310                 315                 320 


Glu Leu Ser Lys Tyr Phe Lys Asn His Ala Ala Ala Pro Ser Val Phe 
                325                 330                 335     


Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val 
            340                 345                 350         


Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp 
        355                 360                 365             


Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr 
    370                 375                 380                 


Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr 
385                 390                 395                 400 


Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val 
                405                 410                 415     


Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly 
            420                 425                 430         


Glu Cys 
        


<210>  60
<211>  460
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MIA-fusion polypeptides

<400>  60

Ser Lys Glu Ile Val Lys Lys Tyr Asn Leu Asn Leu Arg Asn Ala Ile 
1               5                   10                  15      


Leu Asn Asn Asn Ser Gln Ile Glu Asn Glu Glu Asn Asp Ile Lys Tyr 
            20                  25                  30          


Glu Leu Asn Glu Gln Asn Asp Glu Asn Val Asn Thr Pro Ile Val Gly 
        35                  40                  45              


Asn Met Glu Phe Gly Glu Gly Phe Ser Ala Asp Asp Gln Lys Asp Ile 
    50                  55                  60                  


Glu Ala Tyr Lys Lys Ala Lys Gln Ala Ser Gln Asp Ala Glu Gln Ala 
65                  70                  75                  80  


Ala Lys Asp Ala Glu Asn Ala Ala Lys Asp Ala Glu Glu Ala Ala Lys 
                85                  90                  95      


Asp Ala Glu Lys Leu Lys Glu Ser Asp Glu Ser Tyr Thr Lys Ala Lys 
            100                 105                 110         


Glu Ala Cys Thr Ala Ala Ser Lys Ala Lys Lys Ala Val Glu Thr Ala 
        115                 120                 125             


Leu Lys Ala Lys Asp Asp Ala Glu Thr Ala Leu Lys Thr Ser Glu Thr 
    130                 135                 140                 


Pro Glu Lys Pro Ser Arg Ile Asn Leu Phe Ser Arg Lys Thr Lys Glu 
145                 150                 155                 160 


Tyr Ala Glu Lys Ala Lys Asn Ala Tyr Glu Lys Ala Lys Asn Ala Tyr 
                165                 170                 175     


Gln Lys Ala Asn Gln Ala Val Leu Lys Ala Lys Glu Ala Ser Ser Tyr 
            180                 185                 190         


Asp Tyr Ile Leu Gly Trp Glu Phe Gly Gly Gly Val Pro Glu His Lys 
        195                 200                 205             


Lys Glu Glu Asn Met Leu Ser His Leu Tyr Val Ser Ser Lys Asp Lys 
    210                 215                 220                 


Glu Asn Ile Ala Lys Glu Asn Asp Asp Val Leu Asp Glu Lys Glu Glu 
225                 230                 235                 240 


Glu Ala Glu Glu Thr Glu Glu Glu Glu Leu Glu Glu Lys Asn Glu Glu 
                245                 250                 255     


Glu Thr Glu Ser Glu Ile Ser Glu Asp Glu Glu Glu Glu Glu Glu Glu 
            260                 265                 270         


Glu Lys Glu Glu Glu Asn Asp Lys Lys Lys Glu Gln Glu Lys Glu Gln 
        275                 280                 285             


Ser Asn Glu Asn Asn Asp Gln Lys Lys Asp Met Glu Ala Gln Asn Leu 
    290                 295                 300                 


Ile Ser Lys Asn Gln Asn Asn Asn Glu Lys Asn Val Lys Glu Ala Ala 
305                 310                 315                 320 


Glu Ser Ile Met Lys Thr Leu Ala Gly Leu Ile Lys Gly Asn Asn Gln 
                325                 330                 335     


Ile Asp Ser Thr Leu Lys Asp Leu Val Glu Glu Leu Ser Lys Tyr Phe 
            340                 345                 350         


Lys Asn His Ala Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
        355                 360                 365             


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
    370                 375                 380                 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
385                 390                 395                 400 


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
                405                 410                 415     


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
            420                 425                 430         


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
        435                 440                 445             


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    450                 455                 460 


<210>  61
<211>  337
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MIA-fusion polypeptides

<400>  61

Asn Gly Leu Thr Gly Ala Thr Glu Asn Ile Ala Gln Val Val Gln Ala 
1               5                   10                  15      


Asn Ser Glu Thr Asn Lys Asn Pro Thr Ser His Ser Asn Ser Thr Thr 
            20                  25                  30          


Thr Ser Leu Asn Asn Asn Ile Leu Gly Trp Glu Phe Gly Gly Gly Ala 
        35                  40                  45              


Pro Gln Asn Gly Ala Ala Glu Asp Lys Lys Thr Glu Tyr Leu Leu Glu 
    50                  55                  60                  


Gln Ile Lys Ile Pro Ser Trp Asp Arg Asn Asn Ile Pro Asp Glu Asn 
65                  70                  75                  80  


Glu Gln Val Ile Glu Asp Pro Gln Glu Asp Asn Lys Asp Glu Asp Glu 
                85                  90                  95      


Asp Glu Glu Thr Glu Thr Glu Asn Leu Glu Thr Glu Asp Asp Asn Asn 
            100                 105                 110         


Glu Glu Ile Glu Glu Asn Glu Glu Asp Asp Ile Asp Glu Glu Ser Val 
        115                 120                 125             


Glu Glu Lys Glu Glu Glu Glu Glu Lys Lys Glu Glu Glu Glu Lys Lys 
    130                 135                 140                 


Glu Glu Lys Lys Glu Glu Lys Lys Pro Asp Asn Glu Ile Thr Asn Glu 
145                 150                 155                 160 


Val Lys Glu Glu Gln Lys Tyr Ser Ser Pro Ser Asp Ile Asn Ala Gln 
                165                 170                 175     


Asn Leu Ile Ser Asn Lys Asn Lys Lys Asn Asp Glu Thr Lys Lys Thr 
            180                 185                 190         


Ala Glu Asn Ile Val Lys Thr Leu Val Gly Leu Phe Asn Glu Lys Asn 
        195                 200                 205             


Glu Ile Asp Ser Thr Ile Asn Asn Leu Val Gln Glu Met Ile His Leu 
    210                 215                 220                 


Phe Ser Ser Lys Ser Arg Trp Ser Ala Ala Ala Pro Ser Val Phe Ile 
225                 230                 235                 240 


Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val 
                245                 250                 255     


Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys 
            260                 265                 270         


Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu 
        275                 280                 285             


Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu 
    290                 295                 300                 


Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr 
305                 310                 315                 320 


His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu 
                325                 330                 335     


Cys 
    


<210>  62
<211>  279
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MIA-fusion polypeptides

<400>  62

Ser Glu Thr Asp Thr Gln Ser Lys Asn Glu Gln Glu Ile Ser Thr Gln 
1               5                   10                  15      


Gly Gln Glu Val Gln Lys Pro Ala Gln Gly Gly Glu Ser Thr Phe Gln 
            20                  25                  30          


Lys Asp Leu Asp Lys Lys Leu Tyr Asn Leu Gly Asp Val Phe Asn His 
        35                  40                  45              


Val Val Asp Ile Ser Asn Lys Glu Asn Lys Ile Asn Leu Asp Glu His 
    50                  55                  60                  


Asp Lys Lys Tyr Thr Asp Phe Lys Lys Glu Tyr Glu Asp Phe Val Leu 
65                  70                  75                  80  


Asn Ser Lys Glu Tyr Asp Ile Ile Lys Asn Leu Ile Ile Met Phe Gly 
                85                  90                  95      


Gln Glu Asp Asn Lys Ala Lys Asn Gly Lys Thr Asp Ile Val Ser Glu 
            100                 105                 110         


Ala Lys His Ile Thr Glu Ile Phe Ile Lys Leu Phe Lys Asp Lys Glu 
        115                 120                 125             


Tyr His Glu Gln Phe Lys Asn Tyr Ile Tyr Gly Val Tyr Ser Tyr Ala 
    130                 135                 140                 


Lys Gln Asn Ser His Leu Ser Glu Lys Lys Ile Lys Gln Glu Glu Glu 
145                 150                 155                 160 


Tyr Lys Lys Phe Leu Glu Tyr Ser Phe Asn Leu Leu Asn Thr Ala Ala 
                165                 170                 175     


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
            180                 185                 190         


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
        195                 200                 205             


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
    210                 215                 220                 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
225                 230                 235                 240 


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
                245                 250                 255     


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
            260                 265                 270         


Ser Phe Asn Arg Gly Glu Cys 
        275                 


<210>  63
<211>  223
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MIA-fusion polypeptides

<400>  63

Glu Lys Thr Asn Lys Gly Thr Gly Ser Gly Val Ser Ser Lys Lys Lys 
1               5                   10                  15      


Asn Lys Lys Gly Ser Gly Glu Pro Leu Ile Asp Val His Asp Leu Ile 
            20                  25                  30          


Ser Asp Met Ile Lys Lys Glu Glu Glu Leu Val Glu Val Asn Lys Arg 
        35                  40                  45              


Lys Ser Lys Tyr Lys Leu Ala Thr Ser Asn Thr Glu Lys Gly Arg His 
    50                  55                  60                  


Pro Phe Lys Ile Gly Ser Ser Asp Pro Ala Asp Asn Ala Asn Pro Asp 
65                  70                  75                  80  


Ala Asp Ser Glu Ser Asn Gly Glu Pro Asn Ala Asp Pro Gln Val Thr 
                85                  90                  95      


Ala Gln Asp Val Thr Pro Glu Gln Pro Gln Gly Asp Asp Asn Asn Leu 
            100                 105                 110         


Val Ser Gly Pro Glu His Ala Ala Ala Pro Ser Val Phe Ile Phe Pro 
        115                 120                 125             


Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu 
    130                 135                 140                 


Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp 
145                 150                 155                 160 


Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp 
                165                 170                 175     


Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys 
            180                 185                 190         


Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln 
        195                 200                 205             


Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 220             


<210>  64
<211>  388
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MIA-fusion polypeptides

<400>  64

Asp Lys Asn Ser Val Asp Thr Asn Thr Lys Val Trp Glu Cys Lys Lys 
1               5                   10                  15      


Pro Tyr Lys Leu Ser Thr Lys Asp Val Cys Val Pro Pro Arg Arg Gln 
            20                  25                  30          


Glu Leu Cys Leu Gly Asn Ile Asp Arg Ile Tyr Asp Lys Asn Leu Leu 
        35                  40                  45              


Met Ile Lys Glu His Ile Leu Ala Ile Ala Ile Tyr Glu Ser Arg Ile 
    50                  55                  60                  


Leu Lys Arg Lys Tyr Lys Asn Lys Asp Asp Lys Glu Val Cys Lys Ile 
65                  70                  75                  80  


Ile Asn Lys Ala Phe Ala Asp Ile Arg Asp Ile Ile Gly Gly Thr Asp 
                85                  90                  95      


Tyr Trp Asn Asp Leu Ser Asn Arg Lys Leu Val Gly Lys Ile Asn Thr 
            100                 105                 110         


Asn Ser Asn Tyr Val His Arg Asn Lys Gln Asn Asp Lys Leu Phe Arg 
        115                 120                 125             


Asp Glu Trp Trp Lys Val Ile Lys Lys Asp Val Trp Asn Val Ile Ser 
    130                 135                 140                 


Trp Val Phe Lys Asp Lys Thr Val Cys Lys Glu Asp Asp Ile Glu Asn 
145                 150                 155                 160 


Ile Pro Gln Phe Phe Arg Trp Phe Ser Glu Trp Gly Asp Asp Tyr Cys 
                165                 170                 175     


Gln Asp Lys Thr Lys Met Ile Glu Thr Leu Lys Val Glu Cys Lys Glu 
            180                 185                 190         


Lys Pro Cys Glu Asp Asp Asn Cys Lys Arg Lys Cys Asn Ser Tyr Lys 
        195                 200                 205             


Glu Trp Ile Ser Lys Lys Lys Glu Glu Tyr Asn Lys Gln Ala Lys Gln 
    210                 215                 220                 


Tyr Gln Glu Tyr Gln Lys Gly Asn Asn Tyr Lys Met Tyr Ser Glu Phe 
225                 230                 235                 240 


Lys Ser Ile Lys Pro Glu Val Tyr Leu Lys Lys Tyr Ser Glu Lys Cys 
                245                 250                 255     


Ser Asn Leu Asn Phe Glu Asp Glu Phe Lys Glu Glu Leu His Ser Asp 
            260                 265                 270         


Tyr Lys Asn Lys Cys Thr Met Cys Pro Glu Val Ala Ala Ala Pro Ser 
        275                 280                 285             


Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala 
    290                 295                 300                 


Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val 
305                 310                 315                 320 


Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser 
                325                 330                 335     


Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr 
            340                 345                 350         


Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys 
        355                 360                 365             


Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn 
    370                 375                 380                 


Arg Gly Glu Cys 
385             


<210>  65
<211>  555
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MIA-fusion polypeptides

<400>  65

Ile Glu Ile Val Glu Arg Ser Asn Tyr Met Gly Asn Pro Trp Thr Glu 
1               5                   10                  15      


Tyr Met Ala Lys Tyr Asp Ile Glu Glu Val His Gly Ser Gly Ile Arg 
            20                  25                  30          


Val Asp Leu Gly Glu Asp Ala Glu Val Ala Gly Thr Gln Tyr Arg Leu 
        35                  40                  45              


Pro Ser Gly Lys Cys Pro Val Phe Gly Lys Gly Ile Ile Ile Glu Asn 
    50                  55                  60                  


Ser Asn Thr Ala Phe Leu Thr Pro Val Ala Thr Gly Asn Gln Tyr Leu 
65                  70                  75                  80  


Lys Asp Gly Gly Phe Ala Phe Pro Pro Thr Glu Pro Leu Met Ser Pro 
                85                  90                  95      


Met Thr Leu Asp Glu Met Arg His Phe Tyr Lys Asp Asn Lys Tyr Val 
            100                 105                 110         


Lys Asn Leu Asp Glu Leu Thr Leu Cys Ser Arg His Ala Gly Asn Met 
        115                 120                 125             


Ile Pro Asp Asn Asp Lys Asn Ser Asn Tyr Lys Tyr Pro Ala Val Tyr 
    130                 135                 140                 


Asp Asp Lys Asp Lys Lys Cys His Ile Leu Tyr Ile Ala Ala Gln Glu 
145                 150                 155                 160 


Asn Asn Gly Pro Arg Tyr Cys Asn Lys Asp Glu Ser Lys Arg Asn Ser 
                165                 170                 175     


Met Phe Cys Phe Arg Pro Ala Lys Asp Ile Ser Phe Gln Asn Tyr Ala 
            180                 185                 190         


Tyr Leu Ser Lys Asn Val Val Asp Asn Trp Glu Lys Val Cys Pro Arg 
        195                 200                 205             


Lys Asn Leu Gln Asn Ala Lys Phe Gly Leu Trp Val Asp Gly Asn Cys 
    210                 215                 220                 


Glu Asp Ile Pro His Val Asn Glu Phe Pro Ala Ile Asp Leu Phe Glu 
225                 230                 235                 240 


Cys Asn Lys Leu Val Phe Glu Leu Ser Ala Ser Asp Gln Pro Lys Gln 
                245                 250                 255     


Tyr Glu Gln His Leu Thr Asp Tyr Glu Lys Ile Lys Glu Gly Phe Lys 
            260                 265                 270         


Asn Lys Asn Ala Ala Met Ile Lys Ser Ala Phe Leu Pro Thr Gly Ala 
        275                 280                 285             


Phe Lys Ala Asp Arg Tyr Lys Ser His Gly Lys Gly Tyr Asn Trp Gly 
    290                 295                 300                 


Asn Tyr Asn Thr Glu Thr Gln Lys Cys Glu Ile Phe Asn Val Lys Pro 
305                 310                 315                 320 


Thr Cys Leu Ile Asn Asn Ala Ala Tyr Ile Ala Thr Thr Ala Leu Ser 
                325                 330                 335     


His Pro Ile Glu Val Glu Asn Asn Phe Pro Cys Ser Leu Tyr Lys Asp 
            340                 345                 350         


Glu Ile Met Lys Glu Ile Glu Arg Glu Ser Lys Arg Ile Lys Leu Asn 
        355                 360                 365             


Asp Asn Asp Asp Glu Gly Asn Lys Lys Ile Ile Ala Pro Arg Ile Phe 
    370                 375                 380                 


Ile Ser Asp Asp Lys Asp Ser Leu Lys Cys Pro Cys Asp Pro Glu Met 
385                 390                 395                 400 


Val Ser Asn Ser Ala Cys Arg Phe Phe Val Cys Lys Cys Val Glu Arg 
                405                 410                 415     


Arg Ala Glu Val Thr Ser Asn Asn Glu Val Val Val Lys Glu Glu Tyr 
            420                 425                 430         


Lys Asp Glu Tyr Ala Asp Ile Pro Glu His Lys Pro Thr Tyr Asp Lys 
        435                 440                 445             


Met Lys Ala Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
    450                 455                 460                 


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
465                 470                 475                 480 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
                485                 490                 495     


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
            500                 505                 510         


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
        515                 520                 525             


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
    530                 535                 540                 


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
545                 550                 555 


<210>  66
<211>  153
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MIA LC fusions

<400>  66

Met Asp Ile Thr Gln Gln Ala Lys Asp Ile Gly Ala Gly Pro Val Ala 
1               5                   10                  15      


Ser Cys Phe Thr Thr Arg Met Ser Pro Pro Gln Gln Ile Cys Leu Asn 
            20                  25                  30          


Ser Val Val Asn Thr Ala Leu Ser Thr Ser Thr Gln Ser Ala Met Lys 
        35                  40                  45              


Ala Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu 
    50                  55                  60                  


Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro 
65                  70                  75                  80  


Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly 
                85                  90                  95      


Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr 
            100                 105                 110         


Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His 
        115                 120                 125             


Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val 
    130                 135                 140                 


Thr Lys Ser Phe Asn Arg Gly Glu Cys 
145                 150             


<210>  67
<211>  914
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MIAs comprising an additional C-terminal fusion polypeptide

<400>  67

Ile Ser Gln His Gln Cys Val Lys Lys Gln Cys Pro Glu Asn Ser Gly 
1               5                   10                  15      


Cys Phe Arg His Leu Asp Glu Arg Glu Glu Cys Lys Cys Leu Leu Asn 
            20                  25                  30          


Tyr Lys Gln Glu Gly Asp Lys Cys Val Glu Asn Pro Asn Pro Thr Cys 
        35                  40                  45              


Asn Glu Asn Asn Gly Gly Cys Asp Ala Asp Ala Thr Cys Thr Glu Glu 
    50                  55                  60                  


Asp Ser Gly Ser Ser Arg Lys Lys Ile Thr Cys Glu Cys Thr Lys Pro 
65                  70                  75                  80  


Asp Ser Tyr Pro Leu Phe Asp Gly Ile Phe Cys Ser Ser Ser Asn Ala 
                85                  90                  95      


Ala Val Ala Met Ala Ile Ser Gln His Gln Cys Val Lys Lys Gln Cys 
            100                 105                 110         


Pro Glu Asn Ser Gly Cys Phe Arg His Leu Asp Glu Arg Glu Glu Cys 
        115                 120                 125             


Lys Cys Leu Leu Asn Tyr Lys Gln Glu Gly Asp Lys Cys Val Glu Asn 
    130                 135                 140                 


Pro Asn Pro Thr Cys Asn Glu Asn Asn Gly Gly Cys Asp Ala Asp Ala 
145                 150                 155                 160 


Lys Cys Thr Glu Glu Asp Ser Gly Ser Asn Gly Lys Lys Ile Thr Cys 
                165                 170                 175     


Glu Cys Thr Lys Pro Asp Ser Tyr Pro Leu Phe Asp Gly Ile Phe Cys 
            180                 185                 190         


Ser Ser Ser Asn Ala Ala Val Ala Met Ala Ile Ser Gln His Gln Cys 
        195                 200                 205             


Val Lys Lys Gln Cys Pro Gln Asn Ser Gly Cys Phe Arg His Leu Asp 
    210                 215                 220                 


Glu Arg Glu Glu Cys Lys Cys Leu Leu Asn Tyr Lys Gln Glu Gly Asp 
225                 230                 235                 240 


Lys Cys Val Glu Asn Pro Asn Pro Thr Cys Asn Glu Asn Asn Gly Gly 
                245                 250                 255     


Cys Asp Ala Asp Ala Lys Cys Thr Glu Glu Asp Ser Gly Ser Asn Gly 
            260                 265                 270         


Lys Lys Ile Thr Cys Glu Cys Thr Lys Pro Asp Ser Tyr Pro Leu Phe 
        275                 280                 285             


Asp Gly Ile Phe Cys Ser Ser Ser Asn Ala Ala Val Ala Met Ala Ile 
    290                 295                 300                 


Ser Gln His Gln Cys Val Lys Lys Gln Cys Pro Gln Asn Ser Gly Cys 
305                 310                 315                 320 


Phe Arg His Leu Asp Glu Arg Glu Glu Cys Lys Cys Leu Leu Asn Tyr 
                325                 330                 335     


Lys Gln Glu Gly Asp Lys Cys Val Glu Asn Pro Asn Pro Thr Cys Asn 
            340                 345                 350         


Glu Asn Asn Gly Gly Cys Asp Ala Asp Ala Lys Cys Thr Glu Glu Asp 
        355                 360                 365             


Ser Gly Ser Asn Gly Lys Lys Ile Thr Cys Glu Cys Thr Lys Pro Asp 
    370                 375                 380                 


Ser Tyr Pro Phe Phe Asp Gly Ile Phe Cys Ser Ser Ser Asn Ala Ala 
385                 390                 395                 400 


Ala Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 
                405                 410                 415     


Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
            420                 425                 430         


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
        435                 440                 445             


His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
    450                 455                 460                 


Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 
465                 470                 475                 480 


Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val 
                485                 490                 495     


Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
            500                 505                 510         


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
        515                 520                 525             


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
    530                 535                 540                 


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
545                 550                 555                 560 


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
                565                 570                 575     


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
            580                 585                 590         


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
        595                 600                 605             


Phe Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
    610                 615                 620                 


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
625                 630                 635                 640 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
                645                 650                 655     


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
            660                 665                 670         


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
        675                 680                 685             


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
    690                 695                 700                 


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
705                 710                 715                 720 


Ser Leu Ser Leu Ser Pro Gly Lys His Met Val Thr Glu Asn Thr Ile 
                725                 730                 735     


Cys Lys Tyr Gly Tyr Leu Ile Gln Met Ser Asn His Tyr Glu Cys Lys 
            740                 745                 750         


Cys Ile Glu Gly Tyr Val Leu Ile Asn Glu Asp Thr Cys Gly Lys Lys 
        755                 760                 765             


Val Val Cys Asp Lys Val Glu Asn Ser Phe Lys Ala Cys Asp Glu Tyr 
    770                 775                 780                 


Ala Tyr Cys Phe Asp Leu Gly Asn Lys Asn Asn Glu Lys Gln Ile Lys 
785                 790                 795                 800 


Cys Met Cys Arg Thr Glu Tyr Thr Leu Thr Ala Gly Val Cys Val Pro 
                805                 810                 815     


Asn Val Cys Arg Asp Lys Val Cys Gly Lys Gly Lys Cys Ile Val Asp 
            820                 825                 830         


Pro Ala Asn Ser Leu Thr His Thr Cys Ser Cys Asn Ile Gly Thr Ile 
        835                 840                 845             


Leu Asn Gln Asn Lys Leu Cys Asp Ile Gln Gly Asp Thr Pro Cys Ser 
    850                 855                 860                 


Leu Lys Cys Ala Glu Asn Glu Val Cys Thr Leu Glu Gly Asn Tyr Tyr 
865                 870                 875                 880 


Thr Cys Lys Glu Asp Pro Ser Ser Asn Gly Gly Gly Asn Thr Val Asp 
                885                 890                 895     


Gln Ala Ser Ala Ala Ala His His His His His His Ser Glu Lys Asp 
            900                 905                 910         


Glu Leu 
        


<210>  68
<211>  820
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MIAs comprising an additional C-terminal fusion polypeptide

<400>  68

Ile Ser Gln His Gln Cys Val Lys Lys Gln Cys Pro Glu Asn Ser Gly 
1               5                   10                  15      


Cys Phe Arg His Leu Asp Glu Arg Glu Glu Cys Lys Cys Leu Leu Asn 
            20                  25                  30          


Tyr Lys Gln Glu Gly Asp Lys Cys Val Glu Asn Pro Asn Pro Thr Cys 
        35                  40                  45              


Asn Glu Asn Asn Gly Gly Cys Asp Ala Asp Ala Thr Cys Thr Glu Glu 
    50                  55                  60                  


Asp Ser Gly Ser Ser Arg Lys Lys Ile Thr Cys Glu Cys Thr Lys Pro 
65                  70                  75                  80  


Asp Ser Tyr Pro Leu Phe Asp Gly Ile Phe Cys Ser Ser Ser Asn Ala 
                85                  90                  95      


Ala Val Ala Met Ala Ile Ser Gln His Gln Cys Val Lys Lys Gln Cys 
            100                 105                 110         


Pro Glu Asn Ser Gly Cys Phe Arg His Leu Asp Glu Arg Glu Glu Cys 
        115                 120                 125             


Lys Cys Leu Leu Asn Tyr Lys Gln Glu Gly Asp Lys Cys Val Glu Asn 
    130                 135                 140                 


Pro Asn Pro Thr Cys Asn Glu Asn Asn Gly Gly Cys Asp Ala Asp Ala 
145                 150                 155                 160 


Lys Cys Thr Glu Glu Asp Ser Gly Ser Asn Gly Lys Lys Ile Thr Cys 
                165                 170                 175     


Glu Cys Thr Lys Pro Asp Ser Tyr Pro Leu Phe Asp Gly Ile Phe Cys 
            180                 185                 190         


Ser Ser Ser Asn Ala Ala Val Ala Met Ala Ile Ser Gln His Gln Cys 
        195                 200                 205             


Val Lys Lys Gln Cys Pro Gln Asn Ser Gly Cys Phe Arg His Leu Asp 
    210                 215                 220                 


Glu Arg Glu Glu Cys Lys Cys Leu Leu Asn Tyr Lys Gln Glu Gly Asp 
225                 230                 235                 240 


Lys Cys Val Glu Asn Pro Asn Pro Thr Cys Asn Glu Asn Asn Gly Gly 
                245                 250                 255     


Cys Asp Ala Asp Ala Lys Cys Thr Glu Glu Asp Ser Gly Ser Asn Gly 
            260                 265                 270         


Lys Lys Ile Thr Cys Glu Cys Thr Lys Pro Asp Ser Tyr Pro Leu Phe 
        275                 280                 285             


Asp Gly Ile Phe Cys Ser Ser Ser Asn Ala Ala Val Ala Met Ala Ile 
    290                 295                 300                 


Ser Gln His Gln Cys Val Lys Lys Gln Cys Pro Gln Asn Ser Gly Cys 
305                 310                 315                 320 


Phe Arg His Leu Asp Glu Arg Glu Glu Cys Lys Cys Leu Leu Asn Tyr 
                325                 330                 335     


Lys Gln Glu Gly Asp Lys Cys Val Glu Asn Pro Asn Pro Thr Cys Asn 
            340                 345                 350         


Glu Asn Asn Gly Gly Cys Asp Ala Asp Ala Lys Cys Thr Glu Glu Asp 
        355                 360                 365             


Ser Gly Ser Asn Gly Lys Lys Ile Thr Cys Glu Cys Thr Lys Pro Asp 
    370                 375                 380                 


Ser Tyr Pro Phe Phe Asp Gly Ile Phe Cys Ser Ser Ser Asn Ala Ala 
385                 390                 395                 400 


Ala Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 
                405                 410                 415     


Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
            420                 425                 430         


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
        435                 440                 445             


His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
    450                 455                 460                 


Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 
465                 470                 475                 480 


Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val 
                485                 490                 495     


Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
            500                 505                 510         


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
        515                 520                 525             


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
    530                 535                 540                 


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
545                 550                 555                 560 


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
                565                 570                 575     


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
            580                 585                 590         


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
        595                 600                 605             


Phe Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
    610                 615                 620                 


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
625                 630                 635                 640 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
                645                 650                 655     


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
            660                 665                 670         


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
        675                 680                 685             


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
    690                 695                 700                 


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
705                 710                 715                 720 


Ser Leu Ser Leu Ser Pro Gly Lys His Met Ala Pro Ser Asp Lys His 
                725                 730                 735     


Ile Glu Gln Tyr Leu Lys Lys Ile Gln Asn Ser Leu Ser Thr Glu Trp 
            740                 745                 750         


Ser Pro Cys Ser Val Thr Cys Gly Asn Gly Ile Gln Val Arg Ile Lys 
        755                 760                 765             


Pro Gly Ser Ala Asn Lys Pro Lys Asp Glu Leu Asp Tyr Glu Asn Asp 
    770                 775                 780                 


Ile Glu Lys Lys Ile Cys Lys Met Glu Lys Cys Ser Ser Val Phe Asn 
785                 790                 795                 800 


Val Val Asn Ser Ser Ala Ala Ala His His His His His His Ser Glu 
                805                 810                 815     


Lys Asp Glu Leu 
            820 


<210>  69
<211>  1089
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MIAs comprising an additional C-terminal fusion polypeptide

<400>  69

Ile Ser Gln His Gln Cys Val Lys Lys Gln Cys Pro Glu Asn Ser Gly 
1               5                   10                  15      


Cys Phe Arg His Leu Asp Glu Arg Glu Glu Cys Lys Cys Leu Leu Asn 
            20                  25                  30          


Tyr Lys Gln Glu Gly Asp Lys Cys Val Glu Asn Pro Asn Pro Thr Cys 
        35                  40                  45              


Asn Glu Asn Asn Gly Gly Cys Asp Ala Asp Ala Thr Cys Thr Glu Glu 
    50                  55                  60                  


Asp Ser Gly Ser Ser Arg Lys Lys Ile Thr Cys Glu Cys Thr Lys Pro 
65                  70                  75                  80  


Asp Ser Tyr Pro Leu Phe Asp Gly Ile Phe Cys Ser Ser Ser Asn Ala 
                85                  90                  95      


Ala Val Ala Met Ala Ile Ser Gln His Gln Cys Val Lys Lys Gln Cys 
            100                 105                 110         


Pro Glu Asn Ser Gly Cys Phe Arg His Leu Asp Glu Arg Glu Glu Cys 
        115                 120                 125             


Lys Cys Leu Leu Asn Tyr Lys Gln Glu Gly Asp Lys Cys Val Glu Asn 
    130                 135                 140                 


Pro Asn Pro Thr Cys Asn Glu Asn Asn Gly Gly Cys Asp Ala Asp Ala 
145                 150                 155                 160 


Lys Cys Thr Glu Glu Asp Ser Gly Ser Asn Gly Lys Lys Ile Thr Cys 
                165                 170                 175     


Glu Cys Thr Lys Pro Asp Ser Tyr Pro Leu Phe Asp Gly Ile Phe Cys 
            180                 185                 190         


Ser Ser Ser Asn Ala Ala Val Ala Met Ala Ile Ser Gln His Gln Cys 
        195                 200                 205             


Val Lys Lys Gln Cys Pro Gln Asn Ser Gly Cys Phe Arg His Leu Asp 
    210                 215                 220                 


Glu Arg Glu Glu Cys Lys Cys Leu Leu Asn Tyr Lys Gln Glu Gly Asp 
225                 230                 235                 240 


Lys Cys Val Glu Asn Pro Asn Pro Thr Cys Asn Glu Asn Asn Gly Gly 
                245                 250                 255     


Cys Asp Ala Asp Ala Lys Cys Thr Glu Glu Asp Ser Gly Ser Asn Gly 
            260                 265                 270         


Lys Lys Ile Thr Cys Glu Cys Thr Lys Pro Asp Ser Tyr Pro Leu Phe 
        275                 280                 285             


Asp Gly Ile Phe Cys Ser Ser Ser Asn Ala Ala Val Ala Met Ala Ile 
    290                 295                 300                 


Ser Gln His Gln Cys Val Lys Lys Gln Cys Pro Gln Asn Ser Gly Cys 
305                 310                 315                 320 


Phe Arg His Leu Asp Glu Arg Glu Glu Cys Lys Cys Leu Leu Asn Tyr 
                325                 330                 335     


Lys Gln Glu Gly Asp Lys Cys Val Glu Asn Pro Asn Pro Thr Cys Asn 
            340                 345                 350         


Glu Asn Asn Gly Gly Cys Asp Ala Asp Ala Lys Cys Thr Glu Glu Asp 
        355                 360                 365             


Ser Gly Ser Asn Gly Lys Lys Ile Thr Cys Glu Cys Thr Lys Pro Asp 
    370                 375                 380                 


Ser Tyr Pro Phe Phe Asp Gly Ile Phe Cys Ser Ser Ser Asn Ala Ala 
385                 390                 395                 400 


Ala Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 
                405                 410                 415     


Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
            420                 425                 430         


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
        435                 440                 445             


His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
    450                 455                 460                 


Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 
465                 470                 475                 480 


Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val 
                485                 490                 495     


Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
            500                 505                 510         


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
        515                 520                 525             


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
    530                 535                 540                 


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
545                 550                 555                 560 


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
                565                 570                 575     


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
            580                 585                 590         


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
        595                 600                 605             


Phe Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
    610                 615                 620                 


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
625                 630                 635                 640 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
                645                 650                 655     


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
            660                 665                 670         


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
        675                 680                 685             


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
    690                 695                 700                 


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
705                 710                 715                 720 


Ser Leu Ser Leu Ser Pro Gly Lys His Met Val Ala Ala Gly Asp Leu 
                725                 730                 735     


Arg Ile Ser Ser Lys Glu Ile Val Lys Lys Tyr Asn Leu Asn Leu Arg 
            740                 745                 750         


Asn Ala Ile Leu Asn Asn Asn Ser Gln Ile Glu Asn Glu Glu Asn Val 
        755                 760                 765             


Asn Thr Thr Ile Thr Gly Asn Asp Phe Ser Gly Gly Glu Phe Leu Trp 
    770                 775                 780                 


Pro Gly Tyr Thr Glu Glu Leu Lys Ala Lys Lys Ala Ser Glu Asp Ala 
785                 790                 795                 800 


Glu Lys Ala Ala Asn Asp Ala Glu Asn Ala Ser Lys Glu Ala Glu Glu 
                805                 810                 815     


Ala Ala Lys Glu Ala Val Asn Leu Lys Glu Ser Asp Lys Ser Tyr Thr 
            820                 825                 830         


Lys Ala Lys Glu Ala Ala Thr Ala Ala Ser Lys Ala Lys Lys Ala Val 
        835                 840                 845             


Glu Thr Ala Leu Lys Ala Lys Asp Asp Ala Glu Lys Ser Ser Lys Ala 
    850                 855                 860                 


Asp Ser Ile Ser Thr Lys Thr Lys Glu Tyr Ala Glu Lys Ala Lys Asn 
865                 870                 875                 880 


Ala Tyr Glu Lys Ala Lys Asn Ala Tyr Gln Lys Ala Asn Gln Ala Val 
                885                 890                 895     


Leu Lys Ala Lys Glu Ala Ser Ser Tyr Asp Tyr Ile Leu Gly Trp Glu 
            900                 905                 910         


Phe Gly Gly Gly Val Pro Glu His Lys Lys Glu Glu Asn Met Leu Ser 
        915                 920                 925             


His Leu Tyr Val Ser Ser Lys Asp Lys Glu Asn Ile Ala Lys Glu Asn 
    930                 935                 940                 


Asp Asp Val Leu Asp Glu Lys Glu Glu Glu Ala Glu Glu Thr Glu Glu 
945                 950                 955                 960 


Glu Glu Leu Glu Glu Lys Asn Glu Glu Glu Thr Glu Ser Glu Ile Ser 
                965                 970                 975     


Glu Asp Glu Glu Glu Glu Glu Glu Glu Glu Lys Glu Glu Glu Asn Asp 
            980                 985                 990         


Lys Lys Lys Glu Gln Glu Lys Glu  Gln Ser Asn Glu Asn  Asn Asp Gln 
        995                 1000                 1005             


Lys Lys  Asp Met Glu Ala Gln  Asn Leu Ile Ser Lys  Asn Gln Asn 
    1010                 1015                 1020             


Asn Asn  Glu Lys Asn Val Lys  Glu Ala Ala Glu Ser  Ile Met Lys 
    1025                 1030                 1035             


Thr Leu  Ala Gly Leu Ile Lys  Gly Asn Asn Gln Ile  Asp Ser Thr 
    1040                 1045                 1050             


Leu Lys  Asp Leu Val Glu Glu  Leu Ser Lys Tyr Phe  Lys Asn His 
    1055                 1060                 1065             


Ser Lys  Ser Arg Trp Ser Ala  Ala Ala His His His  His His His 
    1070                 1075                 1080             


Ser Glu  Lys Asp Glu Leu 
    1085                 


<210>  70
<211>  1117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MIAs comprising an additional C-terminal fusion polypeptide

<400>  70

Met Ala Ile Ser Gln His Gln Cys Val Lys Lys Gln Cys Pro Glu Asn 
1               5                   10                  15      


Ser Gly Cys Phe Arg His Leu Asp Glu Arg Glu Glu Cys Lys Cys Leu 
            20                  25                  30          


Leu Asn Tyr Lys Gln Glu Gly Asp Lys Cys Val Glu Asn Pro Asn Pro 
        35                  40                  45              


Thr Cys Asn Glu Asn Asn Gly Gly Cys Asp Ala Asp Ala Thr Cys Thr 
    50                  55                  60                  


Glu Glu Asp Ser Gly Ser Ser Arg Lys Lys Ile Thr Cys Glu Cys Thr 
65                  70                  75                  80  


Lys Pro Asp Ser Tyr Pro Leu Phe Asp Gly Ile Phe Cys Ser Ser Ser 
                85                  90                  95      


Asn Ala Ala Val Ala Met Ala Ile Ser Gln His Gln Cys Val Lys Lys 
            100                 105                 110         


Gln Cys Pro Glu Asn Ser Gly Cys Phe Arg His Leu Asp Glu Arg Glu 
        115                 120                 125             


Glu Cys Lys Cys Leu Leu Asn Tyr Lys Gln Glu Gly Asp Lys Cys Val 
    130                 135                 140                 


Glu Asn Pro Asn Pro Thr Cys Asn Glu Asn Asn Gly Gly Cys Asp Ala 
145                 150                 155                 160 


Asp Ala Lys Cys Thr Glu Glu Asp Ser Gly Ser Asn Gly Lys Lys Ile 
                165                 170                 175     


Thr Cys Glu Cys Thr Lys Pro Asp Ser Tyr Pro Leu Phe Asp Gly Ile 
            180                 185                 190         


Phe Cys Ser Ser Ser Asn Ala Ala Val Ala Met Ala Ile Ser Gln His 
        195                 200                 205             


Gln Cys Val Lys Lys Gln Cys Pro Gln Asn Ser Gly Cys Phe Arg His 
    210                 215                 220                 


Leu Asp Glu Arg Glu Glu Cys Lys Cys Leu Leu Asn Tyr Lys Gln Glu 
225                 230                 235                 240 


Gly Asp Lys Cys Val Glu Asn Pro Asn Pro Thr Cys Asn Glu Asn Asn 
                245                 250                 255     


Gly Gly Cys Asp Ala Asp Ala Lys Cys Thr Glu Glu Asp Ser Gly Ser 
            260                 265                 270         


Asn Gly Lys Lys Ile Thr Cys Glu Cys Thr Lys Pro Asp Ser Tyr Pro 
        275                 280                 285             


Leu Phe Asp Gly Ile Phe Cys Ser Ser Ser Asn Ala Ala Val Ala Met 
    290                 295                 300                 


Ala Ile Ser Gln His Gln Cys Val Lys Lys Gln Cys Pro Gln Asn Ser 
305                 310                 315                 320 


Gly Cys Phe Arg His Leu Asp Glu Arg Glu Glu Cys Lys Cys Leu Leu 
                325                 330                 335     


Asn Tyr Lys Gln Glu Gly Asp Lys Cys Val Glu Asn Pro Asn Pro Thr 
            340                 345                 350         


Cys Asn Glu Asn Asn Gly Gly Cys Asp Ala Asp Ala Lys Cys Thr Glu 
        355                 360                 365             


Glu Asp Ser Gly Ser Asn Gly Lys Lys Ile Thr Cys Glu Cys Thr Lys 
    370                 375                 380                 


Pro Asp Ser Tyr Pro Phe Phe Asp Gly Ile Phe Cys Ser Ser Ser Asn 
385                 390                 395                 400 


Ala Ala Ala Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
                405                 410                 415     


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            420                 425                 430         


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        435                 440                 445             


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    450                 455                 460                 


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
465                 470                 475                 480 


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                485                 490                 495     


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            500                 505                 510         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        515                 520                 525             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    530                 535                 540                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
545                 550                 555                 560 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                565                 570                 575     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            580                 585                 590         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        595                 600                 605             


Lys Ala Phe Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    610                 615                 620                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
625                 630                 635                 640 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                645                 650                 655     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            660                 665                 670         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        675                 680                 685             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    690                 695                 700                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
705                 710                 715                 720 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys His Met Val Ala Ala Gly 
                725                 730                 735     


Asp Leu Arg Ile Ser Ser Lys Glu Ile Val Lys Lys Tyr Asn Leu Asn 
            740                 745                 750         


Leu Arg Asn Ala Ile Leu Asn Asn Asn Ser Gln Ile Glu Asn Glu Glu 
        755                 760                 765             


Asn Asp Ile Lys Tyr Glu Leu Asn Glu Gln Asn Asp Glu Asn Val Asn 
    770                 775                 780                 


Thr Pro Ile Val Gly Asn Met Glu Phe Gly Glu Gly Phe Ser Ala Asp 
785                 790                 795                 800 


Asp Gln Lys Asp Ile Glu Ala Tyr Lys Lys Ala Lys Gln Ala Ser Gln 
                805                 810                 815     


Asp Ala Glu Gln Ala Ala Lys Asp Ala Glu Asn Ala Ala Lys Asp Ala 
            820                 825                 830         


Glu Glu Ala Ala Lys Asp Ala Glu Lys Leu Lys Glu Ser Asp Glu Ser 
        835                 840                 845             


Tyr Thr Lys Ala Lys Glu Ala Cys Thr Ala Ala Ser Lys Ala Lys Lys 
    850                 855                 860                 


Ala Val Glu Thr Ala Leu Lys Ala Lys Asp Asp Ala Glu Thr Ala Leu 
865                 870                 875                 880 


Lys Thr Ser Glu Thr Pro Glu Lys Pro Ser Arg Ile Asn Leu Phe Ser 
                885                 890                 895     


Arg Lys Thr Lys Glu Tyr Ala Glu Lys Ala Lys Asn Ala Tyr Glu Lys 
            900                 905                 910         


Ala Lys Asn Ala Tyr Gln Lys Ala Asn Gln Ala Val Leu Lys Ala Lys 
        915                 920                 925             


Glu Ala Ser Ser Tyr Asp Tyr Ile Leu Gly Trp Glu Phe Gly Gly Gly 
    930                 935                 940                 


Val Pro Glu His Lys Lys Glu Glu Asn Met Leu Ser His Leu Tyr Val 
945                 950                 955                 960 


Ser Ser Lys Asp Lys Glu Asn Ile Ala Lys Glu Asn Asp Asp Val Leu 
                965                 970                 975     


Asp Glu Lys Glu Glu Glu Ala Glu Glu Thr Glu Glu Glu Glu Leu Glu 
            980                 985                 990         


Glu Lys Asn Glu Glu Glu Thr Glu  Ser Glu Ile Ser Glu  Asp Glu Glu 
        995                 1000                 1005             


Glu Glu  Glu Glu Glu Glu Lys  Glu Glu Glu Asn Asp  Lys Lys Lys 
    1010                 1015                 1020             


Glu Gln  Glu Lys Glu Gln Ser  Asn Glu Asn Asn Asp  Gln Lys Lys 
    1025                 1030                 1035             


Asp Met  Glu Ala Gln Asn Leu  Ile Ser Lys Asn Gln  Asn Asn Asn 
    1040                 1045                 1050             


Glu Lys  Asn Val Lys Glu Ala  Ala Glu Ser Ile Met  Lys Thr Leu 
    1055                 1060                 1065             


Ala Gly  Leu Ile Lys Gly Asn  Asn Gln Ile Asp Ser  Thr Leu Lys 
    1070                 1075                 1080             


Asp Leu  Val Glu Glu Leu Ser  Lys Tyr Phe Lys Asn  His Ser Lys 
    1085                 1090                 1095             


Ser Arg  Trp Ser Ala Ala Ala  His His His His His  His Ser Glu 
    1100                 1105                 1110             


Lys Asp  Glu Leu 
    1115         


<210>  71
<211>  986
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MIAs comprising an additional C-terminal fusion polypeptide

<400>  71

Ile Ser Gln His Gln Cys Val Lys Lys Gln Cys Pro Glu Asn Ser Gly 
1               5                   10                  15      


Cys Phe Arg His Leu Asp Glu Arg Glu Glu Cys Lys Cys Leu Leu Asn 
            20                  25                  30          


Tyr Lys Gln Glu Gly Asp Lys Cys Val Glu Asn Pro Asn Pro Thr Cys 
        35                  40                  45              


Asn Glu Asn Asn Gly Gly Cys Asp Ala Asp Ala Thr Cys Thr Glu Glu 
    50                  55                  60                  


Asp Ser Gly Ser Ser Arg Lys Lys Ile Thr Cys Glu Cys Thr Lys Pro 
65                  70                  75                  80  


Asp Ser Tyr Pro Leu Phe Asp Gly Ile Phe Cys Ser Ser Ser Asn Ala 
                85                  90                  95      


Ala Val Ala Met Ala Ile Ser Gln His Gln Cys Val Lys Lys Gln Cys 
            100                 105                 110         


Pro Glu Asn Ser Gly Cys Phe Arg His Leu Asp Glu Arg Glu Glu Cys 
        115                 120                 125             


Lys Cys Leu Leu Asn Tyr Lys Gln Glu Gly Asp Lys Cys Val Glu Asn 
    130                 135                 140                 


Pro Asn Pro Thr Cys Asn Glu Asn Asn Gly Gly Cys Asp Ala Asp Ala 
145                 150                 155                 160 


Lys Cys Thr Glu Glu Asp Ser Gly Ser Asn Gly Lys Lys Ile Thr Cys 
                165                 170                 175     


Glu Cys Thr Lys Pro Asp Ser Tyr Pro Leu Phe Asp Gly Ile Phe Cys 
            180                 185                 190         


Ser Ser Ser Asn Ala Ala Val Ala Met Ala Ile Ser Gln His Gln Cys 
        195                 200                 205             


Val Lys Lys Gln Cys Pro Gln Asn Ser Gly Cys Phe Arg His Leu Asp 
    210                 215                 220                 


Glu Arg Glu Glu Cys Lys Cys Leu Leu Asn Tyr Lys Gln Glu Gly Asp 
225                 230                 235                 240 


Lys Cys Val Glu Asn Pro Asn Pro Thr Cys Asn Glu Asn Asn Gly Gly 
                245                 250                 255     


Cys Asp Ala Asp Ala Lys Cys Thr Glu Glu Asp Ser Gly Ser Asn Gly 
            260                 265                 270         


Lys Lys Ile Thr Cys Glu Cys Thr Lys Pro Asp Ser Tyr Pro Leu Phe 
        275                 280                 285             


Asp Gly Ile Phe Cys Ser Ser Ser Asn Ala Ala Val Ala Met Ala Ile 
    290                 295                 300                 


Ser Gln His Gln Cys Val Lys Lys Gln Cys Pro Gln Asn Ser Gly Cys 
305                 310                 315                 320 


Phe Arg His Leu Asp Glu Arg Glu Glu Cys Lys Cys Leu Leu Asn Tyr 
                325                 330                 335     


Lys Gln Glu Gly Asp Lys Cys Val Glu Asn Pro Asn Pro Thr Cys Asn 
            340                 345                 350         


Glu Asn Asn Gly Gly Cys Asp Ala Asp Ala Lys Cys Thr Glu Glu Asp 
        355                 360                 365             


Ser Gly Ser Asn Gly Lys Lys Ile Thr Cys Glu Cys Thr Lys Pro Asp 
    370                 375                 380                 


Ser Tyr Pro Phe Phe Asp Gly Ile Phe Cys Ser Ser Ser Asn Ala Ala 
385                 390                 395                 400 


Ala Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 
                405                 410                 415     


Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
            420                 425                 430         


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
        435                 440                 445             


His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
    450                 455                 460                 


Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 
465                 470                 475                 480 


Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val 
                485                 490                 495     


Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
            500                 505                 510         


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
        515                 520                 525             


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
    530                 535                 540                 


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
545                 550                 555                 560 


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
                565                 570                 575     


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
            580                 585                 590         


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
        595                 600                 605             


Phe Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
    610                 615                 620                 


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
625                 630                 635                 640 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
                645                 650                 655     


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
            660                 665                 670         


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
        675                 680                 685             


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
    690                 695                 700                 


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
705                 710                 715                 720 


Ser Leu Ser Leu Ser Pro Gly Lys His Met Val Ala Ala Gly Asp Leu 
                725                 730                 735     


Arg Ile Ser Asn Gly Leu Thr Gly Ala Thr Glu Asn Ile Ala Gln Val 
            740                 745                 750         


Val Gln Ala Asn Ser Glu Thr Asn Lys Asn Pro Thr Ser His Ser Asn 
        755                 760                 765             


Ser Thr Thr Thr Ser Leu Asn Asn Asn Ile Leu Gly Trp Glu Phe Gly 
    770                 775                 780                 


Gly Gly Ala Pro Gln Asn Gly Ala Ala Glu Asp Lys Lys Thr Glu Tyr 
785                 790                 795                 800 


Leu Leu Glu Gln Ile Lys Ile Pro Ser Trp Asp Arg Asn Asn Ile Pro 
                805                 810                 815     


Asp Glu Asn Glu Gln Val Ile Glu Asp Pro Gln Glu Asp Asn Lys Asp 
            820                 825                 830         


Glu Asp Glu Asp Glu Glu Thr Glu Thr Glu Asn Leu Glu Thr Glu Asp 
        835                 840                 845             


Asp Asn Asn Glu Glu Ile Glu Glu Asn Glu Glu Asp Asp Ile Asp Glu 
    850                 855                 860                 


Glu Ser Val Glu Glu Lys Glu Glu Glu Glu Glu Lys Lys Glu Glu Glu 
865                 870                 875                 880 


Glu Lys Lys Glu Glu Lys Lys Glu Glu Lys Lys Pro Asp Asn Glu Ile 
                885                 890                 895     


Thr Asn Glu Val Lys Glu Glu Gln Lys Tyr Ser Ser Pro Ser Asp Ile 
            900                 905                 910         


Asn Ala Gln Asn Leu Ile Ser Asn Lys Asn Lys Lys Asn Asp Glu Thr 
        915                 920                 925             


Lys Lys Thr Ala Glu Asn Ile Val Lys Thr Leu Val Gly Leu Phe Asn 
    930                 935                 940                 


Glu Lys Asn Glu Ile Asp Ser Thr Ile Asn Asn Leu Val Gln Glu Met 
945                 950                 955                 960 


Ile His Leu Phe Ser Ser Lys Ser Arg Trp Ser Ala Ala Ala His His 
                965                 970                 975     


His His His His Ser Glu Lys Asp Glu Leu 
            980                 985     


<210>  72
<211>  920
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MIAs comprising an additional C-terminal fusion polypeptide

<400>  72

Ile Ser Gln His Gln Cys Val Lys Lys Gln Cys Pro Glu Asn Ser Gly 
1               5                   10                  15      


Cys Phe Arg His Leu Asp Glu Arg Glu Glu Cys Lys Cys Leu Leu Asn 
            20                  25                  30          


Tyr Lys Gln Glu Gly Asp Lys Cys Val Glu Asn Pro Asn Pro Thr Cys 
        35                  40                  45              


Asn Glu Asn Asn Gly Gly Cys Asp Ala Asp Ala Thr Cys Thr Glu Glu 
    50                  55                  60                  


Asp Ser Gly Ser Ser Arg Lys Lys Ile Thr Cys Glu Cys Thr Lys Pro 
65                  70                  75                  80  


Asp Ser Tyr Pro Leu Phe Asp Gly Ile Phe Cys Ser Ser Ser Asn Ala 
                85                  90                  95      


Ala Val Ala Met Ala Ile Ser Gln His Gln Cys Val Lys Lys Gln Cys 
            100                 105                 110         


Pro Glu Asn Ser Gly Cys Phe Arg His Leu Asp Glu Arg Glu Glu Cys 
        115                 120                 125             


Lys Cys Leu Leu Asn Tyr Lys Gln Glu Gly Asp Lys Cys Val Glu Asn 
    130                 135                 140                 


Pro Asn Pro Thr Cys Asn Glu Asn Asn Gly Gly Cys Asp Ala Asp Ala 
145                 150                 155                 160 


Lys Cys Thr Glu Glu Asp Ser Gly Ser Asn Gly Lys Lys Ile Thr Cys 
                165                 170                 175     


Glu Cys Thr Lys Pro Asp Ser Tyr Pro Leu Phe Asp Gly Ile Phe Cys 
            180                 185                 190         


Ser Ser Ser Asn Ala Ala Val Ala Met Ala Ile Ser Gln His Gln Cys 
        195                 200                 205             


Val Lys Lys Gln Cys Pro Gln Asn Ser Gly Cys Phe Arg His Leu Asp 
    210                 215                 220                 


Glu Arg Glu Glu Cys Lys Cys Leu Leu Asn Tyr Lys Gln Glu Gly Asp 
225                 230                 235                 240 


Lys Cys Val Glu Asn Pro Asn Pro Thr Cys Asn Glu Asn Asn Gly Gly 
                245                 250                 255     


Cys Asp Ala Asp Ala Lys Cys Thr Glu Glu Asp Ser Gly Ser Asn Gly 
            260                 265                 270         


Lys Lys Ile Thr Cys Glu Cys Thr Lys Pro Asp Ser Tyr Pro Leu Phe 
        275                 280                 285             


Asp Gly Ile Phe Cys Ser Ser Ser Asn Ala Ala Val Ala Met Ala Ile 
    290                 295                 300                 


Ser Gln His Gln Cys Val Lys Lys Gln Cys Pro Gln Asn Ser Gly Cys 
305                 310                 315                 320 


Phe Arg His Leu Asp Glu Arg Glu Glu Cys Lys Cys Leu Leu Asn Tyr 
                325                 330                 335     


Lys Gln Glu Gly Asp Lys Cys Val Glu Asn Pro Asn Pro Thr Cys Asn 
            340                 345                 350         


Glu Asn Asn Gly Gly Cys Asp Ala Asp Ala Lys Cys Thr Glu Glu Asp 
        355                 360                 365             


Ser Gly Ser Asn Gly Lys Lys Ile Thr Cys Glu Cys Thr Lys Pro Asp 
    370                 375                 380                 


Ser Tyr Pro Phe Phe Asp Gly Ile Phe Cys Ser Ser Ser Asn Ala Ala 
385                 390                 395                 400 


Ala Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 
                405                 410                 415     


Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
            420                 425                 430         


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
        435                 440                 445             


His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
    450                 455                 460                 


Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 
465                 470                 475                 480 


Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val 
                485                 490                 495     


Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
            500                 505                 510         


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
        515                 520                 525             


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
    530                 535                 540                 


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
545                 550                 555                 560 


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
                565                 570                 575     


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
            580                 585                 590         


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
        595                 600                 605             


Phe Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
    610                 615                 620                 


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
625                 630                 635                 640 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
                645                 650                 655     


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
            660                 665                 670         


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
        675                 680                 685             


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
    690                 695                 700                 


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
705                 710                 715                 720 


Ser Leu Ser Leu Ser Pro Gly Lys His Met Gly Ser Glu Thr Asp Thr 
                725                 730                 735     


Gln Ser Lys Asn Glu Gln Glu Ile Ser Thr Gln Gly Gln Glu Val Gln 
            740                 745                 750         


Lys Pro Ala Gln Gly Gly Glu Ser Thr Phe Gln Lys Asp Leu Asp Lys 
        755                 760                 765             


Lys Leu Tyr Asn Leu Gly Asp Val Phe Asn His Val Val Asp Ile Ser 
    770                 775                 780                 


Asn Lys Glu Asn Lys Ile Asn Leu Asp Glu His Asp Lys Lys Tyr Thr 
785                 790                 795                 800 


Asp Phe Lys Lys Glu Tyr Glu Asp Phe Val Leu Asn Ser Lys Glu Tyr 
                805                 810                 815     


Asp Ile Ile Lys Asn Leu Ile Ile Met Phe Gly Gln Glu Asp Asn Lys 
            820                 825                 830         


Ala Lys Asn Gly Lys Thr Asp Ile Val Ser Glu Ala Lys His Ile Thr 
        835                 840                 845             


Glu Ile Phe Ile Lys Leu Phe Lys Asp Lys Glu Tyr His Glu Gln Phe 
    850                 855                 860                 


Lys Asn Tyr Ile Tyr Gly Val Tyr Ser Tyr Ala Lys Gln Asn Ser His 
865                 870                 875                 880 


Leu Ser Glu Lys Lys Ile Lys Gln Glu Glu Glu Tyr Lys Lys Phe Leu 
                885                 890                 895     


Glu Tyr Ser Phe Asn Leu Leu Asn Thr Ala Ala Ala His His His His 
            900                 905                 910         


His His Ser Glu Lys Asp Glu Leu 
        915                 920 


<210>  73
<211>  540
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MIAs comprising an additional C-terminal fusion polypeptide

<400>  73

Thr His Asp Thr Cys Asp Glu Trp Ser Glu Trp Ser Ala Cys Thr His 
1               5                   10                  15      


Gly Ile Ser Thr Arg Lys Cys Leu Ser Asp Ser Ser Ile Lys Asp Glu 
            20                  25                  30          


Thr Leu Val Cys Thr Lys Cys Asp Lys Trp Gly Glu Trp Ser Glu Cys 
        35                  40                  45              


Lys Asp Gly Arg Met His Arg Lys Val Leu Asn Cys Pro Phe Ile Lys 
    50                  55                  60                  


Glu Glu Gln Glu Cys Asp Val Asn Asn Glu Ala Ala Ala Lys Gly Pro 
65                  70                  75                  80  


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
                85                  90                  95      


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
            100                 105                 110         


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
        115                 120                 125             


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
    130                 135                 140                 


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
145                 150                 155                 160 


His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
                165                 170                 175     


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
            180                 185                 190         


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
        195                 200                 205             


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
    210                 215                 220                 


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
225                 230                 235                 240 


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
                245                 250                 255     


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
            260                 265                 270         


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Phe Pro Ala Pro 
        275                 280                 285             


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
    290                 295                 300                 


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
305                 310                 315                 320 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
                325                 330                 335     


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
            340                 345                 350         


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
        355                 360                 365             


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
    370                 375                 380                 


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
385                 390                 395                 400 


Ser Pro Gly Lys His Met Ala Glu Lys Thr Asn Lys Gly Thr Gly Ser 
                405                 410                 415     


Gly Val Ser Ser Lys Lys Lys Asn Lys Lys Gly Ser Gly Glu Pro Leu 
            420                 425                 430         


Ile Asp Val His Asp Leu Ile Ser Asp Met Ile Lys Lys Glu Glu Glu 
        435                 440                 445             


Leu Val Glu Val Asn Lys Arg Lys Ser Lys Tyr Lys Leu Ala Thr Ser 
    450                 455                 460                 


Asn Thr Glu Lys Gly Arg His Pro Phe Lys Ile Gly Ser Ser Asp Pro 
465                 470                 475                 480 


Ala Asp Asn Ala Asn Pro Asp Ala Asp Ser Glu Ser Asn Gly Glu Pro 
                485                 490                 495     


Asn Ala Asp Pro Gln Val Thr Ala Gln Asp Val Thr Pro Glu Gln Pro 
            500                 505                 510         


Gln Gly Asp Asp Asn Asn Leu Val Ser Gly Pro Glu His Ala Ala Ala 
        515                 520                 525             


His His His His His His Ser Glu Lys Asp Glu Leu 
    530                 535                 540 


<210>  74
<211>  1029
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MIAs comprising an additional C-terminal fusion polypeptide

<400>  74

Ile Ser Gln His Gln Cys Val Lys Lys Gln Cys Pro Glu Asn Ser Gly 
1               5                   10                  15      


Cys Phe Arg His Leu Asp Glu Arg Glu Glu Cys Lys Cys Leu Leu Asn 
            20                  25                  30          


Tyr Lys Gln Glu Gly Asp Lys Cys Val Glu Asn Pro Asn Pro Thr Cys 
        35                  40                  45              


Asn Glu Asn Asn Gly Gly Cys Asp Ala Asp Ala Thr Cys Thr Glu Glu 
    50                  55                  60                  


Asp Ser Gly Ser Ser Arg Lys Lys Ile Thr Cys Glu Cys Thr Lys Pro 
65                  70                  75                  80  


Asp Ser Tyr Pro Leu Phe Asp Gly Ile Phe Cys Ser Ser Ser Asn Ala 
                85                  90                  95      


Ala Val Ala Met Ala Ile Ser Gln His Gln Cys Val Lys Lys Gln Cys 
            100                 105                 110         


Pro Glu Asn Ser Gly Cys Phe Arg His Leu Asp Glu Arg Glu Glu Cys 
        115                 120                 125             


Lys Cys Leu Leu Asn Tyr Lys Gln Glu Gly Asp Lys Cys Val Glu Asn 
    130                 135                 140                 


Pro Asn Pro Thr Cys Asn Glu Asn Asn Gly Gly Cys Asp Ala Asp Ala 
145                 150                 155                 160 


Lys Cys Thr Glu Glu Asp Ser Gly Ser Asn Gly Lys Lys Ile Thr Cys 
                165                 170                 175     


Glu Cys Thr Lys Pro Asp Ser Tyr Pro Leu Phe Asp Gly Ile Phe Cys 
            180                 185                 190         


Ser Ser Ser Asn Ala Ala Val Ala Met Ala Ile Ser Gln His Gln Cys 
        195                 200                 205             


Val Lys Lys Gln Cys Pro Gln Asn Ser Gly Cys Phe Arg His Leu Asp 
    210                 215                 220                 


Glu Arg Glu Glu Cys Lys Cys Leu Leu Asn Tyr Lys Gln Glu Gly Asp 
225                 230                 235                 240 


Lys Cys Val Glu Asn Pro Asn Pro Thr Cys Asn Glu Asn Asn Gly Gly 
                245                 250                 255     


Cys Asp Ala Asp Ala Lys Cys Thr Glu Glu Asp Ser Gly Ser Asn Gly 
            260                 265                 270         


Lys Lys Ile Thr Cys Glu Cys Thr Lys Pro Asp Ser Tyr Pro Leu Phe 
        275                 280                 285             


Asp Gly Ile Phe Cys Ser Ser Ser Asn Ala Ala Val Ala Met Ala Ile 
    290                 295                 300                 


Ser Gln His Gln Cys Val Lys Lys Gln Cys Pro Gln Asn Ser Gly Cys 
305                 310                 315                 320 


Phe Arg His Leu Asp Glu Arg Glu Glu Cys Lys Cys Leu Leu Asn Tyr 
                325                 330                 335     


Lys Gln Glu Gly Asp Lys Cys Val Glu Asn Pro Asn Pro Thr Cys Asn 
            340                 345                 350         


Glu Asn Asn Gly Gly Cys Asp Ala Asp Ala Lys Cys Thr Glu Glu Asp 
        355                 360                 365             


Ser Gly Ser Asn Gly Lys Lys Ile Thr Cys Glu Cys Thr Lys Pro Asp 
    370                 375                 380                 


Ser Tyr Pro Phe Phe Asp Gly Ile Phe Cys Ser Ser Ser Asn Ala Ala 
385                 390                 395                 400 


Ala Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 
                405                 410                 415     


Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
            420                 425                 430         


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
        435                 440                 445             


His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
    450                 455                 460                 


Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 
465                 470                 475                 480 


Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val 
                485                 490                 495     


Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
            500                 505                 510         


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
        515                 520                 525             


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
    530                 535                 540                 


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
545                 550                 555                 560 


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
                565                 570                 575     


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
            580                 585                 590         


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
        595                 600                 605             


Phe Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
    610                 615                 620                 


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
625                 630                 635                 640 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
                645                 650                 655     


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
            660                 665                 670         


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
        675                 680                 685             


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
    690                 695                 700                 


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
705                 710                 715                 720 


Ser Leu Ser Leu Ser Pro Gly Lys His Met Ala Asp Lys Asn Ser Val 
                725                 730                 735     


Asp Thr Asn Thr Lys Val Trp Glu Cys Lys Lys Pro Tyr Lys Leu Ser 
            740                 745                 750         


Thr Lys Asp Val Cys Val Pro Pro Arg Arg Gln Glu Leu Cys Leu Gly 
        755                 760                 765             


Asn Ile Asp Arg Ile Tyr Asp Lys Asn Leu Leu Met Ile Lys Glu His 
    770                 775                 780                 


Ile Leu Ala Ile Ala Ile Tyr Glu Ser Arg Ile Leu Lys Arg Lys Tyr 
785                 790                 795                 800 


Lys Asn Lys Asp Asp Lys Glu Val Cys Lys Ile Ile Asn Lys Ala Phe 
                805                 810                 815     


Ala Asp Ile Arg Asp Ile Ile Gly Gly Thr Asp Tyr Trp Asn Asp Leu 
            820                 825                 830         


Ser Asn Arg Lys Leu Val Gly Lys Ile Asn Thr Asn Ser Asn Tyr Val 
        835                 840                 845             


His Arg Asn Lys Gln Asn Asp Lys Leu Phe Arg Asp Glu Trp Trp Lys 
    850                 855                 860                 


Val Ile Lys Lys Asp Val Trp Asn Val Ile Ser Trp Val Phe Lys Asp 
865                 870                 875                 880 


Lys Thr Val Cys Lys Glu Asp Asp Ile Glu Asn Ile Pro Gln Phe Phe 
                885                 890                 895     


Arg Trp Phe Ser Glu Trp Gly Asp Asp Tyr Cys Gln Asp Lys Thr Lys 
            900                 905                 910         


Met Ile Glu Thr Leu Lys Val Glu Cys Lys Glu Lys Pro Cys Glu Asp 
        915                 920                 925             


Asp Asn Cys Lys Arg Lys Cys Asn Ser Tyr Lys Glu Trp Ile Ser Lys 
    930                 935                 940                 


Lys Lys Glu Glu Tyr Asn Lys Gln Ala Lys Gln Tyr Gln Glu Tyr Gln 
945                 950                 955                 960 


Lys Gly Asn Asn Tyr Lys Met Tyr Ser Glu Phe Lys Ser Ile Lys Pro 
                965                 970                 975     


Glu Val Tyr Leu Lys Lys Tyr Ser Glu Lys Cys Ser Asn Leu Asn Phe 
            980                 985                 990         


Glu Asp Glu Phe Lys Glu Glu Leu  His Ser Asp Tyr Lys  Asn Lys Cys 
        995                 1000                 1005             


Thr Met  Cys Pro Glu Val Ala  Ala Ala His His His  His His His 
    1010                 1015                 1020             


Ser Glu  Lys Asp Glu Leu 
    1025                 


<210>  75
<211>  792
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MIAs comprising an additional C-terminal fusion polypeptide

<400>  75

Ile Ser Gln His Gln Cys Val Lys Lys Gln Cys Pro Glu Asn Ser Gly 
1               5                   10                  15      


Cys Phe Arg His Leu Asp Glu Arg Glu Glu Cys Lys Cys Leu Leu Asn 
            20                  25                  30          


Tyr Lys Gln Glu Gly Asp Lys Cys Val Glu Asn Pro Asn Pro Thr Cys 
        35                  40                  45              


Asn Glu Asn Asn Gly Gly Cys Asp Ala Asp Ala Thr Cys Thr Glu Glu 
    50                  55                  60                  


Asp Ser Gly Ser Ser Arg Lys Lys Ile Thr Cys Glu Cys Thr Lys Pro 
65                  70                  75                  80  


Asp Ser Tyr Pro Leu Phe Asp Gly Ile Phe Cys Ser Ser Ser Asn Ala 
                85                  90                  95      


Ala Val Ala Met Ala Ile Ser Gln His Gln Cys Val Lys Lys Gln Cys 
            100                 105                 110         


Pro Glu Asn Ser Gly Cys Phe Arg His Leu Asp Glu Arg Glu Glu Cys 
        115                 120                 125             


Lys Cys Leu Leu Asn Tyr Lys Gln Glu Gly Asp Lys Cys Val Glu Asn 
    130                 135                 140                 


Pro Asn Pro Thr Cys Asn Glu Asn Asn Gly Gly Cys Asp Ala Asp Ala 
145                 150                 155                 160 


Lys Cys Thr Glu Glu Asp Ser Gly Ser Asn Gly Lys Lys Ile Thr Cys 
                165                 170                 175     


Glu Cys Thr Lys Pro Asp Ser Tyr Pro Leu Phe Asp Gly Ile Phe Cys 
            180                 185                 190         


Ser Ser Ser Asn Ala Ala Val Ala Met Ala Ile Ser Gln His Gln Cys 
        195                 200                 205             


Val Lys Lys Gln Cys Pro Gln Asn Ser Gly Cys Phe Arg His Leu Asp 
    210                 215                 220                 


Glu Arg Glu Glu Cys Lys Cys Leu Leu Asn Tyr Lys Gln Glu Gly Asp 
225                 230                 235                 240 


Lys Cys Val Glu Asn Pro Asn Pro Thr Cys Asn Glu Asn Asn Gly Gly 
                245                 250                 255     


Cys Asp Ala Asp Ala Lys Cys Thr Glu Glu Asp Ser Gly Ser Asn Gly 
            260                 265                 270         


Lys Lys Ile Thr Cys Glu Cys Thr Lys Pro Asp Ser Tyr Pro Leu Phe 
        275                 280                 285             


Asp Gly Ile Phe Cys Ser Ser Ser Asn Ala Ala Val Ala Met Ala Ile 
    290                 295                 300                 


Ser Gln His Gln Cys Val Lys Lys Gln Cys Pro Gln Asn Ser Gly Cys 
305                 310                 315                 320 


Phe Arg His Leu Asp Glu Arg Glu Glu Cys Lys Cys Leu Leu Asn Tyr 
                325                 330                 335     


Lys Gln Glu Gly Asp Lys Cys Val Glu Asn Pro Asn Pro Thr Cys Asn 
            340                 345                 350         


Glu Asn Asn Gly Gly Cys Asp Ala Asp Ala Lys Cys Thr Glu Glu Asp 
        355                 360                 365             


Ser Gly Ser Asn Gly Lys Lys Ile Thr Cys Glu Cys Thr Lys Pro Asp 
    370                 375                 380                 


Ser Tyr Pro Phe Phe Asp Gly Ile Phe Cys Ser Ser Ser Asn Ala Ala 
385                 390                 395                 400 


Ala Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 
                405                 410                 415     


Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
            420                 425                 430         


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
        435                 440                 445             


His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
    450                 455                 460                 


Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 
465                 470                 475                 480 


Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val 
                485                 490                 495     


Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
            500                 505                 510         


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
        515                 520                 525             


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
    530                 535                 540                 


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
545                 550                 555                 560 


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
                565                 570                 575     


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
            580                 585                 590         


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
        595                 600                 605             


Phe Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
    610                 615                 620                 


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
625                 630                 635                 640 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
                645                 650                 655     


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
            660                 665                 670         


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
        675                 680                 685             


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
    690                 695                 700                 


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
705                 710                 715                 720 


Ser Leu Ser Leu Ser Pro Gly Lys His Met Asp Ile Thr Gln Gln Ala 
                725                 730                 735     


Lys Asp Ile Gly Ala Gly Pro Val Ala Ser Cys Phe Thr Thr Arg Met 
            740                 745                 750         


Ser Pro Pro Gln Gln Ile Cys Leu Asn Ser Val Val Asn Thr Ala Leu 
        755                 760                 765             


Ser Thr Ser Thr Gln Ser Ala Met Lys Ala Ala Ala His His His His 
    770                 775                 780                 


His His Ser Glu Lys Asp Glu Leu 
785                 790         


<210>  76
<211>  332
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MIAs with modified CH3 regions for Fc-heterodimerization

<400>  76

Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
1               5                   10                  15      


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
            20                  25                  30          


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
        35                  40                  45              


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
    50                  55                  60                  


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
65                  70                  75                  80  


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu 
                85                  90                  95      


Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
            100                 105                 110         


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        115                 120                 125             


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    130                 135                 140                 


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
145                 150                 155                 160 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
                165                 170                 175     


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            180                 185                 190         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Phe 
        195                 200                 205             


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    210                 215                 220                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Lys Leu Thr Lys 
225                 230                 235                 240 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                245                 250                 255     


Ile Ala Val Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
            260                 265                 270         


Thr Pro Pro Val Leu Lys Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
        275                 280                 285             


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
    290                 295                 300                 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
305                 310                 315                 320 


Ser Leu Ser Pro Gly Lys Ser Glu Lys Asp Glu Leu 
                325                 330         


<210>  77
<211>  332
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MIAs with modified CH3 regions for Fc-heterodimerization

<400>  77

Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
1               5                   10                  15      


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
            20                  25                  30          


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
        35                  40                  45              


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
    50                  55                  60                  


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
65                  70                  75                  80  


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu 
                85                  90                  95      


Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
            100                 105                 110         


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        115                 120                 125             


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    130                 135                 140                 


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
145                 150                 155                 160 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
                165                 170                 175     


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            180                 185                 190         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Phe 
        195                 200                 205             


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    210                 215                 220                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
225                 230                 235                 240 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                245                 250                 255     


Ile Ala Val Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Asp Thr 
            260                 265                 270         


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Asp 
        275                 280                 285             


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
    290                 295                 300                 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
305                 310                 315                 320 


Ser Leu Ser Pro Gly Lys Ser Glu Lys Asp Glu Leu 
                325                 330         


<210>  78
<211>  431
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MIAs with modified CH3 regions for Fc-heterodimerization

<400>  78

Ile Ser Gln His Gln Cys Val Lys Lys Gln Cys Pro Glu Asn Ser Gly 
1               5                   10                  15      


Cys Phe Arg His Leu Asp Glu Arg Glu Glu Cys Lys Cys Leu Leu Asn 
            20                  25                  30          


Tyr Lys Gln Glu Gly Asp Lys Cys Val Glu Asn Pro Asn Pro Thr Cys 
        35                  40                  45              


Asn Glu Asn Asn Gly Gly Cys Asp Ala Asp Ala Thr Cys Thr Glu Glu 
    50                  55                  60                  


Asp Ser Gly Ser Ser Arg Lys Lys Ile Thr Cys Glu Cys Thr Lys Pro 
65                  70                  75                  80  


Asp Ser Tyr Pro Leu Phe Asp Gly Ile Phe Cys Ser Ser Ser Asn Ala 
                85                  90                  95      


Ala Ala Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
            100                 105                 110         


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
        115                 120                 125             


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
    130                 135                 140                 


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
145                 150                 155                 160 


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
                165                 170                 175     


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys 
            180                 185                 190         


Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
        195                 200                 205             


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
    210                 215                 220                 


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
225                 230                 235                 240 


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
                245                 250                 255     


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
            260                 265                 270         


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
        275                 280                 285             


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
    290                 295                 300                 


Ala Phe Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
305                 310                 315                 320 


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Lys Leu 
                325                 330                 335     


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
            340                 345                 350         


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
        355                 360                 365             


Tyr Lys Thr Thr Pro Pro Val Leu Lys Ser Asp Gly Ser Phe Phe Leu 
    370                 375                 380                 


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
385                 390                 395                 400 


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
                405                 410                 415     


Lys Ser Leu Ser Leu Ser Pro Gly Lys Ser Glu Lys Asp Glu Leu 
            420                 425                 430     


<210>  79
<211>  431
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MIAs with modified CH3 regions for Fc-heterodimerization

<400>  79

Ile Ser Gln His Gln Cys Val Lys Lys Gln Cys Pro Glu Asn Ser Gly 
1               5                   10                  15      


Cys Phe Arg His Leu Asp Glu Arg Glu Glu Cys Lys Cys Leu Leu Asn 
            20                  25                  30          


Tyr Lys Gln Glu Gly Asp Lys Cys Val Glu Asn Pro Asn Pro Thr Cys 
        35                  40                  45              


Asn Glu Asn Asn Gly Gly Cys Asp Ala Asp Ala Thr Cys Thr Glu Glu 
    50                  55                  60                  


Asp Ser Gly Ser Ser Arg Lys Lys Ile Thr Cys Glu Cys Thr Lys Pro 
65                  70                  75                  80  


Asp Ser Tyr Pro Leu Phe Asp Gly Ile Phe Cys Ser Ser Ser Asn Ala 
                85                  90                  95      


Ala Ala Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
            100                 105                 110         


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
        115                 120                 125             


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
    130                 135                 140                 


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
145                 150                 155                 160 


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
                165                 170                 175     


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys 
            180                 185                 190         


Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
        195                 200                 205             


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
    210                 215                 220                 


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
225                 230                 235                 240 


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
                245                 250                 255     


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
            260                 265                 270         


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
        275                 280                 285             


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
    290                 295                 300                 


Ala Phe Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
305                 310                 315                 320 


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
                325                 330                 335     


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
            340                 345                 350         


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
        355                 360                 365             


Tyr Asp Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
    370                 375                 380                 


Tyr Ser Asp Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
385                 390                 395                 400 


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
                405                 410                 415     


Lys Ser Leu Ser Leu Ser Pro Gly Lys Ser Glu Lys Asp Glu Leu 
            420                 425                 430     


<210>  80
<211>  505
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MIAs with modified CH3 regions for Fc-heterodimerization

<400>  80

Val Thr Val Asp Thr Val Cys Lys Arg Gly Phe Leu Ile Gln Met Ser 
1               5                   10                  15      


Gly His Leu Glu Cys Lys Cys Glu Asn Asp Thr Val Leu Val Asn Glu 
            20                  25                  30          


Glu Thr Cys Glu Glu Lys Val Leu Lys Cys Asp Glu Lys Thr Val Asn 
        35                  40                  45              


Lys Pro Cys Gly Asp Phe Ser Lys Cys Ile Lys Ile Asp Gly Asn Pro 
    50                  55                  60                  


Val Ser Tyr Ala Cys Lys Cys Asn Leu Gly Tyr Asp Met Val Asn Asn 
65                  70                  75                  80  


Val Cys Ile Pro Asn Glu Cys Lys Asn Val Thr Cys Gly Asn Gly Lys 
                85                  90                  95      


Cys Ile Leu Asp Thr Ser Asn Pro Val Lys Thr Gly Val Cys Ser Cys 
            100                 105                 110         


Asn Ile Gly Lys Val Pro Asn Val Gln Asp Gln Lys Cys Ser Lys Asp 
        115                 120                 125             


Gly Glu Thr Lys Cys Ser Leu Lys Cys Leu Lys Glu Asn Glu Thr Cys 
    130                 135                 140                 


Lys Ala Val Asp Gly Ile Tyr Lys Cys Asp Cys Lys Asp Gly Phe Ile 
145                 150                 155                 160 


Ile Asp Asn Glu Ala Ser Ile Cys Thr Ala Ala Ala Lys Gly Pro Ser 
                165                 170                 175     


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
            180                 185                 190         


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
        195                 200                 205             


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
    210                 215                 220                 


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
225                 230                 235                 240 


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
                245                 250                 255     


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
            260                 265                 270         


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
        275                 280                 285             


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
    290                 295                 300                 


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
305                 310                 315                 320 


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
                325                 330                 335     


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
            340                 345                 350         


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
        355                 360                 365             


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Phe Pro Ala Pro Ile 
    370                 375                 380                 


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
385                 390                 395                 400 


Tyr Thr Leu Pro Pro Ser Arg Asp Lys Leu Thr Lys Asn Gln Val Ser 
                405                 410                 415     


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
            420                 425                 430         


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
        435                 440                 445             


Val Leu Lys Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
    450                 455                 460                 


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
465                 470                 475                 480 


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
                485                 490                 495     


Pro Gly Lys Ser Glu Lys Asp Glu Leu 
            500                 505 


<210>  81
<211>  505
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MIAs with modified CH3 regions for Fc-heterodimerization

<400>  81

Val Thr Val Asp Thr Val Cys Lys Arg Gly Phe Leu Ile Gln Met Ser 
1               5                   10                  15      


Gly His Leu Glu Cys Lys Cys Glu Asn Asp Thr Val Leu Val Asn Glu 
            20                  25                  30          


Glu Thr Cys Glu Glu Lys Val Leu Lys Cys Asp Glu Lys Thr Val Asn 
        35                  40                  45              


Lys Pro Cys Gly Asp Phe Ser Lys Cys Ile Lys Ile Asp Gly Asn Pro 
    50                  55                  60                  


Val Ser Tyr Ala Cys Lys Cys Asn Leu Gly Tyr Asp Met Val Asn Asn 
65                  70                  75                  80  


Val Cys Ile Pro Asn Glu Cys Lys Asn Val Thr Cys Gly Asn Gly Lys 
                85                  90                  95      


Cys Ile Leu Asp Thr Ser Asn Pro Val Lys Thr Gly Val Cys Ser Cys 
            100                 105                 110         


Asn Ile Gly Lys Val Pro Asn Val Gln Asp Gln Lys Cys Ser Lys Asp 
        115                 120                 125             


Gly Glu Thr Lys Cys Ser Leu Lys Cys Leu Lys Glu Asn Glu Thr Cys 
    130                 135                 140                 


Lys Ala Val Asp Gly Ile Tyr Lys Cys Asp Cys Lys Asp Gly Phe Ile 
145                 150                 155                 160 


Ile Asp Asn Glu Ala Ser Ile Cys Thr Ala Ala Ala Lys Gly Pro Ser 
                165                 170                 175     


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
            180                 185                 190         


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
        195                 200                 205             


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
    210                 215                 220                 


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
225                 230                 235                 240 


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
                245                 250                 255     


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
            260                 265                 270         


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
        275                 280                 285             


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
    290                 295                 300                 


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
305                 310                 315                 320 


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
                325                 330                 335     


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
            340                 345                 350         


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
        355                 360                 365             


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Phe Pro Ala Pro Ile 
    370                 375                 380                 


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
385                 390                 395                 400 


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
                405                 410                 415     


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
            420                 425                 430         


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Asp Thr Thr Pro Pro 
        435                 440                 445             


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Asp Leu Thr Val 
    450                 455                 460                 


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
465                 470                 475                 480 


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
                485                 490                 495     


Pro Gly Lys Ser Glu Lys Asp Glu Leu 
            500                 505 


<210>  82
<211>  410
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MIAs with modified CH3 regions for Fc-heterodimerization

<400>  82

Thr His Asp Thr Cys Asp Glu Trp Ser Glu Trp Ser Ala Cys Thr His 
1               5                   10                  15      


Gly Ile Ser Thr Arg Lys Cys Leu Ser Asp Ser Ser Ile Lys Asp Glu 
            20                  25                  30          


Thr Leu Val Cys Thr Lys Cys Asp Lys Trp Gly Glu Trp Ser Glu Cys 
        35                  40                  45              


Lys Asp Gly Arg Met His Arg Lys Val Leu Asn Cys Pro Phe Ile Lys 
    50                  55                  60                  


Glu Glu Gln Glu Cys Asp Val Asn Asn Glu Ala Ala Ala Lys Gly Pro 
65                  70                  75                  80  


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
                85                  90                  95      


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
            100                 105                 110         


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
        115                 120                 125             


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
    130                 135                 140                 


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
145                 150                 155                 160 


His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
                165                 170                 175     


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
            180                 185                 190         


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
        195                 200                 205             


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
    210                 215                 220                 


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
225                 230                 235                 240 


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
                245                 250                 255     


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
            260                 265                 270         


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Phe Pro Ala Pro 
        275                 280                 285             


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
    290                 295                 300                 


Val Tyr Thr Leu Pro Pro Ser Arg Asp Lys Leu Thr Lys Asn Gln Val 
305                 310                 315                 320 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
                325                 330                 335     


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
            340                 345                 350         


Pro Val Leu Lys Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
        355                 360                 365             


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
    370                 375                 380                 


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
385                 390                 395                 400 


Ser Pro Gly Lys Ser Glu Lys Asp Glu Leu 
                405                 410 


<210>  83
<211>  410
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MIAs with modified CH3 regions for Fc-heterodimerization

<400>  83

Thr His Asp Thr Cys Asp Glu Trp Ser Glu Trp Ser Ala Cys Thr His 
1               5                   10                  15      


Gly Ile Ser Thr Arg Lys Cys Leu Ser Asp Ser Ser Ile Lys Asp Glu 
            20                  25                  30          


Thr Leu Val Cys Thr Lys Cys Asp Lys Trp Gly Glu Trp Ser Glu Cys 
        35                  40                  45              


Lys Asp Gly Arg Met His Arg Lys Val Leu Asn Cys Pro Phe Ile Lys 
    50                  55                  60                  


Glu Glu Gln Glu Cys Asp Val Asn Asn Glu Ala Ala Ala Lys Gly Pro 
65                  70                  75                  80  


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
                85                  90                  95      


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
            100                 105                 110         


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
        115                 120                 125             


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
    130                 135                 140                 


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
145                 150                 155                 160 


His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
                165                 170                 175     


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
            180                 185                 190         


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
        195                 200                 205             


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
    210                 215                 220                 


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
225                 230                 235                 240 


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
                245                 250                 255     


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
            260                 265                 270         


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Phe Pro Ala Pro 
        275                 280                 285             


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
    290                 295                 300                 


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
305                 310                 315                 320 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
                325                 330                 335     


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Asp Thr Thr Pro 
            340                 345                 350         


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Asp Leu Thr 
        355                 360                 365             


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
    370                 375                 380                 


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
385                 390                 395                 400 


Ser Pro Gly Lys Ser Glu Lys Asp Glu Leu 
                405                 410 


<210>  84
<211>  786
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MIAs with modified CH3 regions for Fc-heterodimerization

<400>  84

Ile Glu Ile Val Glu Arg Ser Asn Tyr Met Gly Asn Pro Trp Thr Glu 
1               5                   10                  15      


Tyr Met Ala Lys Tyr Asp Ile Glu Glu Val His Gly Ser Gly Ile Arg 
            20                  25                  30          


Val Asp Leu Gly Glu Asp Ala Glu Val Ala Gly Thr Gln Tyr Arg Leu 
        35                  40                  45              


Pro Ser Gly Lys Cys Pro Val Phe Gly Lys Gly Ile Ile Ile Glu Asn 
    50                  55                  60                  


Ser Asn Thr Ala Phe Leu Thr Pro Val Ala Thr Gly Asn Gln Tyr Leu 
65                  70                  75                  80  


Lys Asp Gly Gly Phe Ala Phe Pro Pro Thr Glu Pro Leu Met Ser Pro 
                85                  90                  95      


Met Thr Leu Asp Glu Met Arg His Phe Tyr Lys Asp Asn Lys Tyr Val 
            100                 105                 110         


Lys Asn Leu Asp Glu Leu Thr Leu Cys Ser Arg His Ala Gly Asn Met 
        115                 120                 125             


Ile Pro Asp Asn Asp Lys Asn Ser Asn Tyr Lys Tyr Pro Ala Val Tyr 
    130                 135                 140                 


Asp Asp Lys Asp Lys Lys Cys His Ile Leu Tyr Ile Ala Ala Gln Glu 
145                 150                 155                 160 


Asn Asn Gly Pro Arg Tyr Cys Asn Lys Asp Glu Ser Lys Arg Asn Ser 
                165                 170                 175     


Met Phe Cys Phe Arg Pro Ala Lys Asp Ile Ser Phe Gln Asn Tyr Ala 
            180                 185                 190         


Tyr Leu Ser Lys Asn Val Val Asp Asn Trp Glu Lys Val Cys Pro Arg 
        195                 200                 205             


Lys Asn Leu Gln Asn Ala Lys Phe Gly Leu Trp Val Asp Gly Asn Cys 
    210                 215                 220                 


Glu Asp Ile Pro His Val Asn Glu Phe Pro Ala Ile Asp Leu Phe Glu 
225                 230                 235                 240 


Cys Asn Lys Leu Val Phe Glu Leu Ser Ala Ser Asp Gln Pro Lys Gln 
                245                 250                 255     


Tyr Glu Gln His Leu Thr Asp Tyr Glu Lys Ile Lys Glu Gly Phe Lys 
            260                 265                 270         


Asn Lys Asn Ala Ala Met Ile Lys Ser Ala Phe Leu Pro Thr Gly Ala 
        275                 280                 285             


Phe Lys Ala Asp Arg Tyr Lys Ser His Gly Lys Gly Tyr Asn Trp Gly 
    290                 295                 300                 


Asn Tyr Asn Thr Glu Thr Gln Lys Cys Glu Ile Phe Asn Val Lys Pro 
305                 310                 315                 320 


Thr Cys Leu Ile Asn Asn Ala Ala Tyr Ile Ala Thr Thr Ala Leu Ser 
                325                 330                 335     


His Pro Ile Glu Val Glu Asn Asn Phe Pro Cys Ser Leu Tyr Lys Asp 
            340                 345                 350         


Glu Ile Met Lys Glu Ile Glu Arg Glu Ser Lys Arg Ile Lys Leu Asn 
        355                 360                 365             


Asp Asn Asp Asp Glu Gly Asn Lys Lys Ile Ile Ala Pro Arg Ile Phe 
    370                 375                 380                 


Ile Ser Asp Asp Lys Asp Ser Leu Lys Cys Pro Cys Asp Pro Glu Met 
385                 390                 395                 400 


Val Ser Asn Ser Ala Cys Arg Phe Phe Val Cys Lys Cys Val Glu Arg 
                405                 410                 415     


Arg Ala Glu Val Thr Ser Asn Asn Glu Val Val Val Lys Glu Glu Tyr 
            420                 425                 430         


Lys Asp Glu Tyr Ala Asp Ile Pro Glu His Lys Pro Thr Tyr Asp Lys 
        435                 440                 445             


Met Lys Ala Ala Ala Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser 
    450                 455                 460                 


Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys 
465                 470                 475                 480 


Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
                485                 490                 495     


Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
            500                 505                 510         


Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr 
        515                 520                 525             


Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val 
    530                 535                 540                 


Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro 
545                 550                 555                 560 


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
                565                 570                 575     


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
            580                 585                 590         


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
        595                 600                 605             


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
    610                 615                 620                 


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
625                 630                 635                 640 


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
                645                 650                 655     


Ser Asn Lys Ala Phe Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
            660                 665                 670         


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
        675                 680                 685             


Asp Lys Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
    690                 695                 700                 


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
705                 710                 715                 720 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Lys Ser Asp Gly Ser 
                725                 730                 735     


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
            740                 745                 750         


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
        755                 760                 765             


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Ser Glu Lys Asp 
    770                 775                 780                 


Glu Leu 
785     


<210>  85
<211>  786
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MIAs with modified CH3 regions for Fc-heterodimerization

<400>  85

Ile Glu Ile Val Glu Arg Ser Asn Tyr Met Gly Asn Pro Trp Thr Glu 
1               5                   10                  15      


Tyr Met Ala Lys Tyr Asp Ile Glu Glu Val His Gly Ser Gly Ile Arg 
            20                  25                  30          


Val Asp Leu Gly Glu Asp Ala Glu Val Ala Gly Thr Gln Tyr Arg Leu 
        35                  40                  45              


Pro Ser Gly Lys Cys Pro Val Phe Gly Lys Gly Ile Ile Ile Glu Asn 
    50                  55                  60                  


Ser Asn Thr Ala Phe Leu Thr Pro Val Ala Thr Gly Asn Gln Tyr Leu 
65                  70                  75                  80  


Lys Asp Gly Gly Phe Ala Phe Pro Pro Thr Glu Pro Leu Met Ser Pro 
                85                  90                  95      


Met Thr Leu Asp Glu Met Arg His Phe Tyr Lys Asp Asn Lys Tyr Val 
            100                 105                 110         


Lys Asn Leu Asp Glu Leu Thr Leu Cys Ser Arg His Ala Gly Asn Met 
        115                 120                 125             


Ile Pro Asp Asn Asp Lys Asn Ser Asn Tyr Lys Tyr Pro Ala Val Tyr 
    130                 135                 140                 


Asp Asp Lys Asp Lys Lys Cys His Ile Leu Tyr Ile Ala Ala Gln Glu 
145                 150                 155                 160 


Asn Asn Gly Pro Arg Tyr Cys Asn Lys Asp Glu Ser Lys Arg Asn Ser 
                165                 170                 175     


Met Phe Cys Phe Arg Pro Ala Lys Asp Ile Ser Phe Gln Asn Tyr Ala 
            180                 185                 190         


Tyr Leu Ser Lys Asn Val Val Asp Asn Trp Glu Lys Val Cys Pro Arg 
        195                 200                 205             


Lys Asn Leu Gln Asn Ala Lys Phe Gly Leu Trp Val Asp Gly Asn Cys 
    210                 215                 220                 


Glu Asp Ile Pro His Val Asn Glu Phe Pro Ala Ile Asp Leu Phe Glu 
225                 230                 235                 240 


Cys Asn Lys Leu Val Phe Glu Leu Ser Ala Ser Asp Gln Pro Lys Gln 
                245                 250                 255     


Tyr Glu Gln His Leu Thr Asp Tyr Glu Lys Ile Lys Glu Gly Phe Lys 
            260                 265                 270         


Asn Lys Asn Ala Ala Met Ile Lys Ser Ala Phe Leu Pro Thr Gly Ala 
        275                 280                 285             


Phe Lys Ala Asp Arg Tyr Lys Ser His Gly Lys Gly Tyr Asn Trp Gly 
    290                 295                 300                 


Asn Tyr Asn Thr Glu Thr Gln Lys Cys Glu Ile Phe Asn Val Lys Pro 
305                 310                 315                 320 


Thr Cys Leu Ile Asn Asn Ala Ala Tyr Ile Ala Thr Thr Ala Leu Ser 
                325                 330                 335     


His Pro Ile Glu Val Glu Asn Asn Phe Pro Cys Ser Leu Tyr Lys Asp 
            340                 345                 350         


Glu Ile Met Lys Glu Ile Glu Arg Glu Ser Lys Arg Ile Lys Leu Asn 
        355                 360                 365             


Asp Asn Asp Asp Glu Gly Asn Lys Lys Ile Ile Ala Pro Arg Ile Phe 
    370                 375                 380                 


Ile Ser Asp Asp Lys Asp Ser Leu Lys Cys Pro Cys Asp Pro Glu Met 
385                 390                 395                 400 


Val Ser Asn Ser Ala Cys Arg Phe Phe Val Cys Lys Cys Val Glu Arg 
                405                 410                 415     


Arg Ala Glu Val Thr Ser Asn Asn Glu Val Val Val Lys Glu Glu Tyr 
            420                 425                 430         


Lys Asp Glu Tyr Ala Asp Ile Pro Glu His Lys Pro Thr Tyr Asp Lys 
        435                 440                 445             


Met Lys Ala Ala Ala Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser 
    450                 455                 460                 


Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys 
465                 470                 475                 480 


Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
                485                 490                 495     


Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
            500                 505                 510         


Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr 
        515                 520                 525             


Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val 
    530                 535                 540                 


Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro 
545                 550                 555                 560 


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
                565                 570                 575     


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
            580                 585                 590         


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
        595                 600                 605             


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
    610                 615                 620                 


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
625                 630                 635                 640 


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
                645                 650                 655     


Ser Asn Lys Ala Phe Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
            660                 665                 670         


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
        675                 680                 685             


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
    690                 695                 700                 


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
705                 710                 715                 720 


Glu Asn Asn Tyr Asp Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
                725                 730                 735     


Phe Phe Leu Tyr Ser Asp Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
            740                 745                 750         


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
        755                 760                 765             


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Ser Glu Lys Asp 
    770                 775                 780                 


Glu Leu 
785     


<210>  86
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MIAs with modified CH3 regions for Fc-heterodimerization

<400>  86

Lys Lys Tyr Glu Thr Tyr Val Asp Met Lys Thr Ile Glu Ser Lys Tyr 
1               5                   10                  15      


Thr Thr Val Met Thr Leu Ser Glu His Leu Leu Glu Tyr Ala Met Asp 
            20                  25                  30          


Val Leu Lys Ala Asn Pro Gln Lys Pro Ile Asp Pro Lys Ala Asn Leu 
        35                  40                  45              


Asp Ser Glu Val Val Lys Leu Gln Ile Lys Ile Asn Glu Lys Ser Asn 
    50                  55                  60                  


Glu Leu Asp Asn Ala Ala Ser Gln Val Lys Thr Leu Ile Ile Ile Met 
65                  70                  75                  80  


Lys Ser Phe Tyr Asp Ile Ile Ile Ser Glu Lys Ala Ser Met Asp Glu 
                85                  90                  95      


Met Glu Lys Lys Glu Leu Ser Leu Asn Asn Tyr Ile Glu Lys Thr Asp 
            100                 105                 110         


Tyr 
    


<210>  87
<211>  449
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MIAs with modified CH3 regions for Fc-heterodimerization

<400>  87

Lys Lys Tyr Glu Thr Tyr Val Asp Met Lys Thr Ile Glu Ser Lys Tyr 
1               5                   10                  15      


Thr Thr Val Met Thr Leu Ser Glu His Leu Leu Glu Tyr Ala Met Asp 
            20                  25                  30          


Val Leu Lys Ala Asn Pro Gln Lys Pro Ile Asp Pro Lys Ala Asn Leu 
        35                  40                  45              


Asp Ser Glu Val Val Lys Leu Gln Ile Lys Ile Asn Glu Lys Ser Asn 
    50                  55                  60                  


Glu Leu Asp Asn Ala Ala Ser Gln Val Lys Thr Leu Ile Ile Ile Met 
65                  70                  75                  80  


Lys Ser Phe Tyr Asp Ile Ile Ile Ser Glu Lys Ala Ser Met Asp Glu 
                85                  90                  95      


Met Glu Lys Lys Glu Leu Ser Leu Asn Asn Tyr Ile Glu Lys Thr Asp 
            100                 105                 110         


Tyr Ala Ala Ala Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser 
        115                 120                 125             


Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
    130                 135                 140                 


Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
145                 150                 155                 160 


Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
                165                 170                 175     


Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln 
            180                 185                 190         


Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp 
        195                 200                 205             


Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
    210                 215                 220                 


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
225                 230                 235                 240 


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
                245                 250                 255     


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
            260                 265                 270         


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
        275                 280                 285             


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
    290                 295                 300                 


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
305                 310                 315                 320 


Asn Lys Ala Phe Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
                325                 330                 335     


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
            340                 345                 350         


Lys Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
        355                 360                 365             


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
    370                 375                 380                 


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Lys Ser Asp Gly Ser Phe 
385                 390                 395                 400 


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
                405                 410                 415     


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
            420                 425                 430         


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Ser Glu Lys Asp Glu 
        435                 440                 445             


Leu 
    


<210>  88
<211>  449
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MIAs with modified CH3 regions for Fc-heterodimerization

<400>  88

Lys Lys Tyr Glu Thr Tyr Val Asp Met Lys Thr Ile Glu Ser Lys Tyr 
1               5                   10                  15      


Thr Thr Val Met Thr Leu Ser Glu His Leu Leu Glu Tyr Ala Met Asp 
            20                  25                  30          


Val Leu Lys Ala Asn Pro Gln Lys Pro Ile Asp Pro Lys Ala Asn Leu 
        35                  40                  45              


Asp Ser Glu Val Val Lys Leu Gln Ile Lys Ile Asn Glu Lys Ser Asn 
    50                  55                  60                  


Glu Leu Asp Asn Ala Ala Ser Gln Val Lys Thr Leu Ile Ile Ile Met 
65                  70                  75                  80  


Lys Ser Phe Tyr Asp Ile Ile Ile Ser Glu Lys Ala Ser Met Asp Glu 
                85                  90                  95      


Met Glu Lys Lys Glu Leu Ser Leu Asn Asn Tyr Ile Glu Lys Thr Asp 
            100                 105                 110         


Tyr Ala Ala Ala Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser 
        115                 120                 125             


Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
    130                 135                 140                 


Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
145                 150                 155                 160 


Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
                165                 170                 175     


Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln 
            180                 185                 190         


Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp 
        195                 200                 205             


Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
    210                 215                 220                 


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
225                 230                 235                 240 


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
                245                 250                 255     


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
            260                 265                 270         


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
        275                 280                 285             


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
    290                 295                 300                 


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
305                 310                 315                 320 


Asn Lys Ala Phe Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
                325                 330                 335     


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
            340                 345                 350         


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
        355                 360                 365             


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
    370                 375                 380                 


Asn Asn Tyr Asp Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
385                 390                 395                 400 


Phe Leu Tyr Ser Asp Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
                405                 410                 415     


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
            420                 425                 430         


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Ser Glu Lys Asp Glu 
        435                 440                 445             


Leu 
    


<210>  89
<211>  653
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MIAs with modified CH3 regions for Fc-heterodimerization

<400>  89

Asp Ser Arg His Val Phe Ile Arg Thr Glu Leu Ser Phe Ile Lys Asn 
1               5                   10                  15      


Asn Val Pro Cys Ile Arg Asp Met Phe Phe Ile Tyr Lys Arg Glu Leu 
            20                  25                  30          


Tyr Asn Ile Cys Leu Asp Asp Leu Lys Gly Glu Glu Asp Glu Thr His 
        35                  40                  45              


Ile Tyr Val Gln Lys Lys Val Lys Asp Ser Trp Ile Thr Leu Asn Asp 
    50                  55                  60                  


Leu Phe Lys Glu Thr Asp Leu Thr Gly Arg Pro His Ile Phe Ala Tyr 
65                  70                  75                  80  


Val Asp Val Glu Glu Ile Ile Ile Leu Leu Cys Glu Asp Glu Glu Phe 
                85                  90                  95      


Ser Asn Arg Lys Lys Asp Met Thr Cys His Arg Phe Tyr Ser Asn Asp 
            100                 105                 110         


Gly Lys Glu Tyr Asn Asn Ser Glu Ile Thr Ile Ser Asp Tyr Ile Leu 
        115                 120                 125             


Lys Asp Lys Leu Leu Ser Ser Tyr Val Ser Leu Pro Leu Lys Ile Glu 
    130                 135                 140                 


Asn Arg Glu Tyr Phe Leu Ile Cys Gly Val Ser Pro Tyr Lys Phe Lys 
145                 150                 155                 160 


Asp Asp Asn Lys Lys Asp Asp Ile Leu Cys Met Ala Ser His Asp Lys 
                165                 170                 175     


Gly Glu Thr Trp Gly Thr Lys Ile Val Ile Lys Tyr Asp Asn Tyr Lys 
            180                 185                 190         


Leu Gly Val Gln Tyr Phe Phe Leu Arg Pro Tyr Ile Ser Lys Asn Asp 
        195                 200                 205             


Leu Ser Phe His Phe Tyr Val Gly Asp Asn Ile Asn Asn Val Lys Asn 
    210                 215                 220                 


Val Asn Phe Ile Glu Cys Thr His Glu Lys Asp Leu Glu Phe Val Cys 
225                 230                 235                 240 


Ser Asn Arg Asp Phe Leu Lys Asp Asn Lys Val Leu Gln Asp Val Ser 
                245                 250                 255     


Thr Leu Asn Asp Glu Tyr Ile Val Ser Tyr Gly Asn Asp Asn Asn Phe 
            260                 265                 270         


Ala Glu Cys Tyr Ile Phe Phe Asn Asn Glu Asn Ser Ile Leu Ile Lys 
        275                 280                 285             


Pro Glu Lys Tyr Gly Asn Thr Thr Ala Gly Cys Tyr Gly Gly Thr Phe 
    290                 295                 300                 


Val Lys Ile Asp Glu Asn Arg Thr Leu Phe Ile Tyr Ser Ala Ala Ala 
305                 310                 315                 320 


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
                325                 330                 335     


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
            340                 345                 350         


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
        355                 360                 365             


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
    370                 375                 380                 


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
385                 390                 395                 400 


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu 
                405                 410                 415     


Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
            420                 425                 430         


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        435                 440                 445             


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    450                 455                 460                 


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
465                 470                 475                 480 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
                485                 490                 495     


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            500                 505                 510         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Phe 
        515                 520                 525             


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    530                 535                 540                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Lys Leu Thr Lys 
545                 550                 555                 560 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                565                 570                 575     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            580                 585                 590         


Thr Thr Pro Pro Val Leu Lys Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        595                 600                 605             


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
    610                 615                 620                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
625                 630                 635                 640 


Leu Ser Leu Ser Pro Gly Lys Ser Glu Lys Asp Glu Leu 
                645                 650             


<210>  90
<211>  653
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MIAs with modified CH3 regions for Fc-heterodimerization

<400>  90

Asp Ser Arg His Val Phe Ile Arg Thr Glu Leu Ser Phe Ile Lys Asn 
1               5                   10                  15      


Asn Val Pro Cys Ile Arg Asp Met Phe Phe Ile Tyr Lys Arg Glu Leu 
            20                  25                  30          


Tyr Asn Ile Cys Leu Asp Asp Leu Lys Gly Glu Glu Asp Glu Thr His 
        35                  40                  45              


Ile Tyr Val Gln Lys Lys Val Lys Asp Ser Trp Ile Thr Leu Asn Asp 
    50                  55                  60                  


Leu Phe Lys Glu Thr Asp Leu Thr Gly Arg Pro His Ile Phe Ala Tyr 
65                  70                  75                  80  


Val Asp Val Glu Glu Ile Ile Ile Leu Leu Cys Glu Asp Glu Glu Phe 
                85                  90                  95      


Ser Asn Arg Lys Lys Asp Met Thr Cys His Arg Phe Tyr Ser Asn Asp 
            100                 105                 110         


Gly Lys Glu Tyr Asn Asn Ser Glu Ile Thr Ile Ser Asp Tyr Ile Leu 
        115                 120                 125             


Lys Asp Lys Leu Leu Ser Ser Tyr Val Ser Leu Pro Leu Lys Ile Glu 
    130                 135                 140                 


Asn Arg Glu Tyr Phe Leu Ile Cys Gly Val Ser Pro Tyr Lys Phe Lys 
145                 150                 155                 160 


Asp Asp Asn Lys Lys Asp Asp Ile Leu Cys Met Ala Ser His Asp Lys 
                165                 170                 175     


Gly Glu Thr Trp Gly Thr Lys Ile Val Ile Lys Tyr Asp Asn Tyr Lys 
            180                 185                 190         


Leu Gly Val Gln Tyr Phe Phe Leu Arg Pro Tyr Ile Ser Lys Asn Asp 
        195                 200                 205             


Leu Ser Phe His Phe Tyr Val Gly Asp Asn Ile Asn Asn Val Lys Asn 
    210                 215                 220                 


Val Asn Phe Ile Glu Cys Thr His Glu Lys Asp Leu Glu Phe Val Cys 
225                 230                 235                 240 


Ser Asn Arg Asp Phe Leu Lys Asp Asn Lys Val Leu Gln Asp Val Ser 
                245                 250                 255     


Thr Leu Asn Asp Glu Tyr Ile Val Ser Tyr Gly Asn Asp Asn Asn Phe 
            260                 265                 270         


Ala Glu Cys Tyr Ile Phe Phe Asn Asn Glu Asn Ser Ile Leu Ile Lys 
        275                 280                 285             


Pro Glu Lys Tyr Gly Asn Thr Thr Ala Gly Cys Tyr Gly Gly Thr Phe 
    290                 295                 300                 


Val Lys Ile Asp Glu Asn Arg Thr Leu Phe Ile Tyr Ser Ala Ala Ala 
305                 310                 315                 320 


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
                325                 330                 335     


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
            340                 345                 350         


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
        355                 360                 365             


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
    370                 375                 380                 


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
385                 390                 395                 400 


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu 
                405                 410                 415     


Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
            420                 425                 430         


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        435                 440                 445             


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    450                 455                 460                 


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
465                 470                 475                 480 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
                485                 490                 495     


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            500                 505                 510         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Phe 
        515                 520                 525             


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    530                 535                 540                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
545                 550                 555                 560 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                565                 570                 575     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Asp 
            580                 585                 590         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        595                 600                 605             


Asp Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
    610                 615                 620                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
625                 630                 635                 640 


Leu Ser Leu Ser Pro Gly Lys Ser Glu Lys Asp Glu Leu 
                645                 650             


<210>  91
<211>  609
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MIAs with modified CH3 regions for Fc-heterodimerization

<400>  91

Asn Glu Asp Arg Gly Ile Tyr Asp Glu Leu Leu Glu Asn Asp Met Cys 
1               5                   10                  15      


Asp Leu Tyr Asn Leu Lys Met His Asp Leu His Asn Leu Lys Ser Tyr 
            20                  25                  30          


Asp Phe Gly Leu Ser Lys Asp Leu Leu Lys Lys Asp Ile Phe Ile Tyr 
        35                  40                  45              


Ser Asn Asn Leu Lys Asn Asp Asp Met Asp Asp Asp Asp Asn Asn Asn 
    50                  55                  60                  


Met Asn Asp Ile Ala Ile Gly Glu Asn Val Ile Tyr Glu Asn Asp Ile 
65                  70                  75                  80  


His Glu Asn Asn Ile Asp Asp Asn Asp Met Tyr Asn Asn Tyr Val Asn 
                85                  90                  95      


Gly Asn Asp Leu Tyr Ile Asn Asn Met Gln Asp Asp Ala Met Asp Asp 
            100                 105                 110         


Ile Val Tyr Asp Glu Glu Glu Ile Lys Ser Phe Leu Asp Lys Leu Lys 
        115                 120                 125             


Ser Asp Ile Ser Asn Gln Met Asn Val Lys Asn Gly Asn Val Glu Val 
    130                 135                 140                 


Thr Gly Asn Gly Gly Asn Glu Glu Met Ser Tyr Ile Asn Asn Asp Glu 
145                 150                 155                 160 


Asn Leu Gln Ala Phe Asp Leu Leu Asp Asn Phe His Met Asp Asp Tyr 
                165                 170                 175     


Gly Asn Asn Tyr Asn Asp Asn Glu Glu Asp Gly Asp Gly Asp Gly Asp 
            180                 185                 190         


Asp Asp Glu Gln Lys Lys Arg Lys Gln Lys Glu Leu His Asn Val Asn 
        195                 200                 205             


Gly Lys Leu Asp Leu Ser Asp Leu Asn Glu Leu Asn Val Asp Asp Ile 
    210                 215                 220                 


Asn Asn Asn Phe Tyr Met Ser Thr Pro Arg Lys Ser Ile Asp Glu Arg 
225                 230                 235                 240 


Lys Asp Thr Glu Cys Gln Thr Asp Phe Pro Leu Leu Asp Val Ser Arg 
                245                 250                 255     


Asn Thr Asp Arg Thr Pro Arg Arg Lys Ser Val Glu Val Ile Leu Val 
            260                 265                 270         


Glu Ala Ala Ala Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser 
        275                 280                 285             


Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
    290                 295                 300                 


Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
305                 310                 315                 320 


Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
                325                 330                 335     


Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln 
            340                 345                 350         


Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp 
        355                 360                 365             


Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
    370                 375                 380                 


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
385                 390                 395                 400 


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
                405                 410                 415     


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
            420                 425                 430         


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
        435                 440                 445             


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
    450                 455                 460                 


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
465                 470                 475                 480 


Asn Lys Ala Phe Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
                485                 490                 495     


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
            500                 505                 510         


Lys Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
        515                 520                 525             


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
    530                 535                 540                 


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Lys Ser Asp Gly Ser Phe 
545                 550                 555                 560 


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
                565                 570                 575     


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
            580                 585                 590         


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Ser Glu Lys Asp Glu 
        595                 600                 605             


Leu 
    


<210>  92
<211>  609
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MIAs with modified CH3 regions for Fc-heterodimerization

<400>  92

Asn Glu Asp Arg Gly Ile Tyr Asp Glu Leu Leu Glu Asn Asp Met Cys 
1               5                   10                  15      


Asp Leu Tyr Asn Leu Lys Met His Asp Leu His Asn Leu Lys Ser Tyr 
            20                  25                  30          


Asp Phe Gly Leu Ser Lys Asp Leu Leu Lys Lys Asp Ile Phe Ile Tyr 
        35                  40                  45              


Ser Asn Asn Leu Lys Asn Asp Asp Met Asp Asp Asp Asp Asn Asn Asn 
    50                  55                  60                  


Met Asn Asp Ile Ala Ile Gly Glu Asn Val Ile Tyr Glu Asn Asp Ile 
65                  70                  75                  80  


His Glu Asn Asn Ile Asp Asp Asn Asp Met Tyr Asn Asn Tyr Val Asn 
                85                  90                  95      


Gly Asn Asp Leu Tyr Ile Asn Asn Met Gln Asp Asp Ala Met Asp Asp 
            100                 105                 110         


Ile Val Tyr Asp Glu Glu Glu Ile Lys Ser Phe Leu Asp Lys Leu Lys 
        115                 120                 125             


Ser Asp Ile Ser Asn Gln Met Asn Val Lys Asn Gly Asn Val Glu Val 
    130                 135                 140                 


Thr Gly Asn Gly Gly Asn Glu Glu Met Ser Tyr Ile Asn Asn Asp Glu 
145                 150                 155                 160 


Asn Leu Gln Ala Phe Asp Leu Leu Asp Asn Phe His Met Asp Asp Tyr 
                165                 170                 175     


Gly Asn Asn Tyr Asn Asp Asn Glu Glu Asp Gly Asp Gly Asp Gly Asp 
            180                 185                 190         


Asp Asp Glu Gln Lys Lys Arg Lys Gln Lys Glu Leu His Asn Val Asn 
        195                 200                 205             


Gly Lys Leu Asp Leu Ser Asp Leu Asn Glu Leu Asn Val Asp Asp Ile 
    210                 215                 220                 


Asn Asn Asn Phe Tyr Met Ser Thr Pro Arg Lys Ser Ile Asp Glu Arg 
225                 230                 235                 240 


Lys Asp Thr Glu Cys Gln Thr Asp Phe Pro Leu Leu Asp Val Ser Arg 
                245                 250                 255     


Asn Thr Asp Arg Thr Pro Arg Arg Lys Ser Val Glu Val Ile Leu Val 
            260                 265                 270         


Glu Ala Ala Ala Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser 
        275                 280                 285             


Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
    290                 295                 300                 


Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
305                 310                 315                 320 


Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
                325                 330                 335     


Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln 
            340                 345                 350         


Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp 
        355                 360                 365             


Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
    370                 375                 380                 


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
385                 390                 395                 400 


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
                405                 410                 415     


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
            420                 425                 430         


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
        435                 440                 445             


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
    450                 455                 460                 


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
465                 470                 475                 480 


Asn Lys Ala Phe Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
                485                 490                 495     


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
            500                 505                 510         


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
        515                 520                 525             


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
    530                 535                 540                 


Asn Asn Tyr Asp Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
545                 550                 555                 560 


Phe Leu Tyr Ser Asp Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
                565                 570                 575     


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
            580                 585                 590         


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Ser Glu Lys Asp Glu 
        595                 600                 605             


Leu 
    


<210>  93
<211>  820
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MIA-C fusion polypeptides

<400>  93

Ile Ser Gln His Gln Cys Val Lys Lys Gln Cys Pro Glu Asn Ser Gly 
1               5                   10                  15      


Cys Phe Arg His Leu Asp Glu Arg Glu Glu Cys Lys Cys Leu Leu Asn 
            20                  25                  30          


Tyr Lys Gln Glu Gly Asp Lys Cys Val Glu Asn Pro Asn Pro Thr Cys 
        35                  40                  45              


Asn Glu Asn Asn Gly Gly Cys Asp Ala Asp Ala Thr Cys Thr Glu Glu 
    50                  55                  60                  


Asp Ser Gly Ser Ser Arg Lys Lys Ile Thr Cys Glu Cys Thr Lys Pro 
65                  70                  75                  80  


Asp Ser Tyr Pro Leu Phe Asp Gly Ile Phe Cys Ser Ser Ser Asn Ala 
                85                  90                  95      


Ala Val Ala Met Ala Ile Ser Gln His Gln Cys Val Lys Lys Gln Cys 
            100                 105                 110         


Pro Glu Asn Ser Gly Cys Phe Arg His Leu Asp Glu Arg Glu Glu Cys 
        115                 120                 125             


Lys Cys Leu Leu Asn Tyr Lys Gln Glu Gly Asp Lys Cys Val Glu Asn 
    130                 135                 140                 


Pro Asn Pro Thr Cys Asn Glu Asn Asn Gly Gly Cys Asp Ala Asp Ala 
145                 150                 155                 160 


Lys Cys Thr Glu Glu Asp Ser Gly Ser Asn Gly Lys Lys Ile Thr Cys 
                165                 170                 175     


Glu Cys Thr Lys Pro Asp Ser Tyr Pro Leu Phe Asp Gly Ile Phe Cys 
            180                 185                 190         


Ser Ser Ser Asn Ala Ala Val Ala Met Ala Ile Ser Gln His Gln Cys 
        195                 200                 205             


Val Lys Lys Gln Cys Pro Gln Asn Ser Gly Cys Phe Arg His Leu Asp 
    210                 215                 220                 


Glu Arg Glu Glu Cys Lys Cys Leu Leu Asn Tyr Lys Gln Glu Gly Asp 
225                 230                 235                 240 


Lys Cys Val Glu Asn Pro Asn Pro Thr Cys Asn Glu Asn Asn Gly Gly 
                245                 250                 255     


Cys Asp Ala Asp Ala Lys Cys Thr Glu Glu Asp Ser Gly Ser Asn Gly 
            260                 265                 270         


Lys Lys Ile Thr Cys Glu Cys Thr Lys Pro Asp Ser Tyr Pro Leu Phe 
        275                 280                 285             


Asp Gly Ile Phe Cys Ser Ser Ser Asn Ala Ala Val Ala Met Ala Ile 
    290                 295                 300                 


Ser Gln His Gln Cys Val Lys Lys Gln Cys Pro Gln Asn Ser Gly Cys 
305                 310                 315                 320 


Phe Arg His Leu Asp Glu Arg Glu Glu Cys Lys Cys Leu Leu Asn Tyr 
                325                 330                 335     


Lys Gln Glu Gly Asp Lys Cys Val Glu Asn Pro Asn Pro Thr Cys Asn 
            340                 345                 350         


Glu Asn Asn Gly Gly Cys Asp Ala Asp Ala Lys Cys Thr Glu Glu Asp 
        355                 360                 365             


Ser Gly Ser Asn Gly Lys Lys Ile Thr Cys Glu Cys Thr Lys Pro Asp 
    370                 375                 380                 


Ser Tyr Pro Phe Phe Asp Gly Ile Phe Cys Ser Ser Ser Asn Ala Ala 
385                 390                 395                 400 


Ala Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 
                405                 410                 415     


Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
            420                 425                 430         


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
        435                 440                 445             


His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
    450                 455                 460                 


Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 
465                 470                 475                 480 


Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val 
                485                 490                 495     


Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
            500                 505                 510         


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
        515                 520                 525             


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
    530                 535                 540                 


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
545                 550                 555                 560 


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
                565                 570                 575     


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
            580                 585                 590         


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
        595                 600                 605             


Phe Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
    610                 615                 620                 


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Lys Leu Thr 
625                 630                 635                 640 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
                645                 650                 655     


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
            660                 665                 670         


Lys Thr Thr Pro Pro Val Leu Lys Ser Asp Gly Ser Phe Phe Leu Tyr 
        675                 680                 685             


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
    690                 695                 700                 


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
705                 710                 715                 720 


Ser Leu Ser Leu Ser Pro Gly Lys His Met Ala Pro Ser Asp Lys His 
                725                 730                 735     


Ile Glu Gln Tyr Leu Lys Lys Ile Gln Asn Ser Leu Ser Thr Glu Trp 
            740                 745                 750         


Ser Pro Cys Ser Val Thr Cys Gly Asn Gly Ile Gln Val Arg Ile Lys 
        755                 760                 765             


Pro Gly Ser Ala Asn Lys Pro Lys Asp Glu Leu Asp Tyr Glu Asn Asp 
    770                 775                 780                 


Ile Glu Lys Lys Ile Cys Lys Met Glu Lys Cys Ser Ser Val Phe Asn 
785                 790                 795                 800 


Val Val Asn Ser Ser Ala Ala Ala His His His His His His Ser Glu 
                805                 810                 815     


Lys Asp Glu Leu 
            820 


<210>  94
<211>  820
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MIA-C fusion polypeptides

<400>  94

Ile Ser Gln His Gln Cys Val Lys Lys Gln Cys Pro Glu Asn Ser Gly 
1               5                   10                  15      


Cys Phe Arg His Leu Asp Glu Arg Glu Glu Cys Lys Cys Leu Leu Asn 
            20                  25                  30          


Tyr Lys Gln Glu Gly Asp Lys Cys Val Glu Asn Pro Asn Pro Thr Cys 
        35                  40                  45              


Asn Glu Asn Asn Gly Gly Cys Asp Ala Asp Ala Thr Cys Thr Glu Glu 
    50                  55                  60                  


Asp Ser Gly Ser Ser Arg Lys Lys Ile Thr Cys Glu Cys Thr Lys Pro 
65                  70                  75                  80  


Asp Ser Tyr Pro Leu Phe Asp Gly Ile Phe Cys Ser Ser Ser Asn Ala 
                85                  90                  95      


Ala Val Ala Met Ala Ile Ser Gln His Gln Cys Val Lys Lys Gln Cys 
            100                 105                 110         


Pro Glu Asn Ser Gly Cys Phe Arg His Leu Asp Glu Arg Glu Glu Cys 
        115                 120                 125             


Lys Cys Leu Leu Asn Tyr Lys Gln Glu Gly Asp Lys Cys Val Glu Asn 
    130                 135                 140                 


Pro Asn Pro Thr Cys Asn Glu Asn Asn Gly Gly Cys Asp Ala Asp Ala 
145                 150                 155                 160 


Lys Cys Thr Glu Glu Asp Ser Gly Ser Asn Gly Lys Lys Ile Thr Cys 
                165                 170                 175     


Glu Cys Thr Lys Pro Asp Ser Tyr Pro Leu Phe Asp Gly Ile Phe Cys 
            180                 185                 190         


Ser Ser Ser Asn Ala Ala Val Ala Met Ala Ile Ser Gln His Gln Cys 
        195                 200                 205             


Val Lys Lys Gln Cys Pro Gln Asn Ser Gly Cys Phe Arg His Leu Asp 
    210                 215                 220                 


Glu Arg Glu Glu Cys Lys Cys Leu Leu Asn Tyr Lys Gln Glu Gly Asp 
225                 230                 235                 240 


Lys Cys Val Glu Asn Pro Asn Pro Thr Cys Asn Glu Asn Asn Gly Gly 
                245                 250                 255     


Cys Asp Ala Asp Ala Lys Cys Thr Glu Glu Asp Ser Gly Ser Asn Gly 
            260                 265                 270         


Lys Lys Ile Thr Cys Glu Cys Thr Lys Pro Asp Ser Tyr Pro Leu Phe 
        275                 280                 285             


Asp Gly Ile Phe Cys Ser Ser Ser Asn Ala Ala Val Ala Met Ala Ile 
    290                 295                 300                 


Ser Gln His Gln Cys Val Lys Lys Gln Cys Pro Gln Asn Ser Gly Cys 
305                 310                 315                 320 


Phe Arg His Leu Asp Glu Arg Glu Glu Cys Lys Cys Leu Leu Asn Tyr 
                325                 330                 335     


Lys Gln Glu Gly Asp Lys Cys Val Glu Asn Pro Asn Pro Thr Cys Asn 
            340                 345                 350         


Glu Asn Asn Gly Gly Cys Asp Ala Asp Ala Lys Cys Thr Glu Glu Asp 
        355                 360                 365             


Ser Gly Ser Asn Gly Lys Lys Ile Thr Cys Glu Cys Thr Lys Pro Asp 
    370                 375                 380                 


Ser Tyr Pro Phe Phe Asp Gly Ile Phe Cys Ser Ser Ser Asn Ala Ala 
385                 390                 395                 400 


Ala Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 
                405                 410                 415     


Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
            420                 425                 430         


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
        435                 440                 445             


His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
    450                 455                 460                 


Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 
465                 470                 475                 480 


Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val 
                485                 490                 495     


Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
            500                 505                 510         


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
        515                 520                 525             


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
    530                 535                 540                 


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
545                 550                 555                 560 


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
                565                 570                 575     


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
            580                 585                 590         


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
        595                 600                 605             


Phe Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
    610                 615                 620                 


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
625                 630                 635                 640 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
                645                 650                 655     


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
            660                 665                 670         


Asp Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
        675                 680                 685             


Ser Asp Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
    690                 695                 700                 


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
705                 710                 715                 720 


Ser Leu Ser Leu Ser Pro Gly Lys His Met Ala Pro Ser Asp Lys His 
                725                 730                 735     


Ile Glu Gln Tyr Leu Lys Lys Ile Gln Asn Ser Leu Ser Thr Glu Trp 
            740                 745                 750         


Ser Pro Cys Ser Val Thr Cys Gly Asn Gly Ile Gln Val Arg Ile Lys 
        755                 760                 765             


Pro Gly Ser Ala Asn Lys Pro Lys Asp Glu Leu Asp Tyr Glu Asn Asp 
    770                 775                 780                 


Ile Glu Lys Lys Ile Cys Lys Met Glu Lys Cys Ser Ser Val Phe Asn 
785                 790                 795                 800 


Val Val Asn Ser Ser Ala Ala Ala His His His His His His Ser Glu 
                805                 810                 815     


Lys Asp Glu Leu 
            820 


<210>  95
<211>  792
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MIA-C fusion polypeptides

<400>  95

Ile Ser Gln His Gln Cys Val Lys Lys Gln Cys Pro Glu Asn Ser Gly 
1               5                   10                  15      


Cys Phe Arg His Leu Asp Glu Arg Glu Glu Cys Lys Cys Leu Leu Asn 
            20                  25                  30          


Tyr Lys Gln Glu Gly Asp Lys Cys Val Glu Asn Pro Asn Pro Thr Cys 
        35                  40                  45              


Asn Glu Asn Asn Gly Gly Cys Asp Ala Asp Ala Thr Cys Thr Glu Glu 
    50                  55                  60                  


Asp Ser Gly Ser Ser Arg Lys Lys Ile Thr Cys Glu Cys Thr Lys Pro 
65                  70                  75                  80  


Asp Ser Tyr Pro Leu Phe Asp Gly Ile Phe Cys Ser Ser Ser Asn Ala 
                85                  90                  95      


Ala Val Ala Met Ala Ile Ser Gln His Gln Cys Val Lys Lys Gln Cys 
            100                 105                 110         


Pro Glu Asn Ser Gly Cys Phe Arg His Leu Asp Glu Arg Glu Glu Cys 
        115                 120                 125             


Lys Cys Leu Leu Asn Tyr Lys Gln Glu Gly Asp Lys Cys Val Glu Asn 
    130                 135                 140                 


Pro Asn Pro Thr Cys Asn Glu Asn Asn Gly Gly Cys Asp Ala Asp Ala 
145                 150                 155                 160 


Lys Cys Thr Glu Glu Asp Ser Gly Ser Asn Gly Lys Lys Ile Thr Cys 
                165                 170                 175     


Glu Cys Thr Lys Pro Asp Ser Tyr Pro Leu Phe Asp Gly Ile Phe Cys 
            180                 185                 190         


Ser Ser Ser Asn Ala Ala Val Ala Met Ala Ile Ser Gln His Gln Cys 
        195                 200                 205             


Val Lys Lys Gln Cys Pro Gln Asn Ser Gly Cys Phe Arg His Leu Asp 
    210                 215                 220                 


Glu Arg Glu Glu Cys Lys Cys Leu Leu Asn Tyr Lys Gln Glu Gly Asp 
225                 230                 235                 240 


Lys Cys Val Glu Asn Pro Asn Pro Thr Cys Asn Glu Asn Asn Gly Gly 
                245                 250                 255     


Cys Asp Ala Asp Ala Lys Cys Thr Glu Glu Asp Ser Gly Ser Asn Gly 
            260                 265                 270         


Lys Lys Ile Thr Cys Glu Cys Thr Lys Pro Asp Ser Tyr Pro Leu Phe 
        275                 280                 285             


Asp Gly Ile Phe Cys Ser Ser Ser Asn Ala Ala Val Ala Met Ala Ile 
    290                 295                 300                 


Ser Gln His Gln Cys Val Lys Lys Gln Cys Pro Gln Asn Ser Gly Cys 
305                 310                 315                 320 


Phe Arg His Leu Asp Glu Arg Glu Glu Cys Lys Cys Leu Leu Asn Tyr 
                325                 330                 335     


Lys Gln Glu Gly Asp Lys Cys Val Glu Asn Pro Asn Pro Thr Cys Asn 
            340                 345                 350         


Glu Asn Asn Gly Gly Cys Asp Ala Asp Ala Lys Cys Thr Glu Glu Asp 
        355                 360                 365             


Ser Gly Ser Asn Gly Lys Lys Ile Thr Cys Glu Cys Thr Lys Pro Asp 
    370                 375                 380                 


Ser Tyr Pro Phe Phe Asp Gly Ile Phe Cys Ser Ser Ser Asn Ala Ala 
385                 390                 395                 400 


Ala Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 
                405                 410                 415     


Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
            420                 425                 430         


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
        435                 440                 445             


His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
    450                 455                 460                 


Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 
465                 470                 475                 480 


Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val 
                485                 490                 495     


Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
            500                 505                 510         


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
        515                 520                 525             


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
    530                 535                 540                 


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
545                 550                 555                 560 


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
                565                 570                 575     


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
            580                 585                 590         


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
        595                 600                 605             


Phe Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
    610                 615                 620                 


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Lys Leu Thr 
625                 630                 635                 640 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
                645                 650                 655     


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
            660                 665                 670         


Lys Thr Thr Pro Pro Val Leu Lys Ser Asp Gly Ser Phe Phe Leu Tyr 
        675                 680                 685             


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
    690                 695                 700                 


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
705                 710                 715                 720 


Ser Leu Ser Leu Ser Pro Gly Lys His Met Asp Ile Thr Gln Gln Ala 
                725                 730                 735     


Lys Asp Ile Gly Ala Gly Pro Val Ala Ser Cys Phe Thr Thr Arg Met 
            740                 745                 750         


Ser Pro Pro Gln Gln Ile Cys Leu Asn Ser Val Val Asn Thr Ala Leu 
        755                 760                 765             


Ser Thr Ser Thr Gln Ser Ala Met Lys Ala Ala Ala His His His His 
    770                 775                 780                 


His His Ser Glu Lys Asp Glu Leu 
785                 790         


<210>  96
<211>  792
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MIA-C fusion polypeptides

<400>  96

Ile Ser Gln His Gln Cys Val Lys Lys Gln Cys Pro Glu Asn Ser Gly 
1               5                   10                  15      


Cys Phe Arg His Leu Asp Glu Arg Glu Glu Cys Lys Cys Leu Leu Asn 
            20                  25                  30          


Tyr Lys Gln Glu Gly Asp Lys Cys Val Glu Asn Pro Asn Pro Thr Cys 
        35                  40                  45              


Asn Glu Asn Asn Gly Gly Cys Asp Ala Asp Ala Thr Cys Thr Glu Glu 
    50                  55                  60                  


Asp Ser Gly Ser Ser Arg Lys Lys Ile Thr Cys Glu Cys Thr Lys Pro 
65                  70                  75                  80  


Asp Ser Tyr Pro Leu Phe Asp Gly Ile Phe Cys Ser Ser Ser Asn Ala 
                85                  90                  95      


Ala Val Ala Met Ala Ile Ser Gln His Gln Cys Val Lys Lys Gln Cys 
            100                 105                 110         


Pro Glu Asn Ser Gly Cys Phe Arg His Leu Asp Glu Arg Glu Glu Cys 
        115                 120                 125             


Lys Cys Leu Leu Asn Tyr Lys Gln Glu Gly Asp Lys Cys Val Glu Asn 
    130                 135                 140                 


Pro Asn Pro Thr Cys Asn Glu Asn Asn Gly Gly Cys Asp Ala Asp Ala 
145                 150                 155                 160 


Lys Cys Thr Glu Glu Asp Ser Gly Ser Asn Gly Lys Lys Ile Thr Cys 
                165                 170                 175     


Glu Cys Thr Lys Pro Asp Ser Tyr Pro Leu Phe Asp Gly Ile Phe Cys 
            180                 185                 190         


Ser Ser Ser Asn Ala Ala Val Ala Met Ala Ile Ser Gln His Gln Cys 
        195                 200                 205             


Val Lys Lys Gln Cys Pro Gln Asn Ser Gly Cys Phe Arg His Leu Asp 
    210                 215                 220                 


Glu Arg Glu Glu Cys Lys Cys Leu Leu Asn Tyr Lys Gln Glu Gly Asp 
225                 230                 235                 240 


Lys Cys Val Glu Asn Pro Asn Pro Thr Cys Asn Glu Asn Asn Gly Gly 
                245                 250                 255     


Cys Asp Ala Asp Ala Lys Cys Thr Glu Glu Asp Ser Gly Ser Asn Gly 
            260                 265                 270         


Lys Lys Ile Thr Cys Glu Cys Thr Lys Pro Asp Ser Tyr Pro Leu Phe 
        275                 280                 285             


Asp Gly Ile Phe Cys Ser Ser Ser Asn Ala Ala Val Ala Met Ala Ile 
    290                 295                 300                 


Ser Gln His Gln Cys Val Lys Lys Gln Cys Pro Gln Asn Ser Gly Cys 
305                 310                 315                 320 


Phe Arg His Leu Asp Glu Arg Glu Glu Cys Lys Cys Leu Leu Asn Tyr 
                325                 330                 335     


Lys Gln Glu Gly Asp Lys Cys Val Glu Asn Pro Asn Pro Thr Cys Asn 
            340                 345                 350         


Glu Asn Asn Gly Gly Cys Asp Ala Asp Ala Lys Cys Thr Glu Glu Asp 
        355                 360                 365             


Ser Gly Ser Asn Gly Lys Lys Ile Thr Cys Glu Cys Thr Lys Pro Asp 
    370                 375                 380                 


Ser Tyr Pro Phe Phe Asp Gly Ile Phe Cys Ser Ser Ser Asn Ala Ala 
385                 390                 395                 400 


Ala Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 
                405                 410                 415     


Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
            420                 425                 430         


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
        435                 440                 445             


His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
    450                 455                 460                 


Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 
465                 470                 475                 480 


Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val 
                485                 490                 495     


Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
            500                 505                 510         


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
        515                 520                 525             


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
    530                 535                 540                 


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
545                 550                 555                 560 


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
                565                 570                 575     


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
            580                 585                 590         


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
        595                 600                 605             


Phe Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
    610                 615                 620                 


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
625                 630                 635                 640 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
                645                 650                 655     


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
            660                 665                 670         


Asp Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
        675                 680                 685             


Ser Asp Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
    690                 695                 700                 


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
705                 710                 715                 720 


Ser Leu Ser Leu Ser Pro Gly Lys His Met Asp Ile Thr Gln Gln Ala 
                725                 730                 735     


Lys Asp Ile Gly Ala Gly Pro Val Ala Ser Cys Phe Thr Thr Arg Met 
            740                 745                 750         


Ser Pro Pro Gln Gln Ile Cys Leu Asn Ser Val Val Asn Thr Ala Leu 
        755                 760                 765             


Ser Thr Ser Thr Gln Ser Ala Met Lys Ala Ala Ala His His His His 
    770                 775                 780                 


His His Ser Glu Lys Asp Glu Leu 
785                 790         


<210>  97
<211>  872
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MIA-C fusion polypeptides

<400>  97

Ile Glu Ile Val Glu Arg Ser Asn Tyr Met Gly Asn Pro Trp Thr Glu 
1               5                   10                  15      


Tyr Met Ala Lys Tyr Asp Ile Glu Glu Val His Gly Ser Gly Ile Arg 
            20                  25                  30          


Val Asp Leu Gly Glu Asp Ala Glu Val Ala Gly Thr Gln Tyr Arg Leu 
        35                  40                  45              


Pro Ser Gly Lys Cys Pro Val Phe Gly Lys Gly Ile Ile Ile Glu Asn 
    50                  55                  60                  


Ser Asn Thr Ala Phe Leu Thr Pro Val Ala Thr Gly Asn Gln Tyr Leu 
65                  70                  75                  80  


Lys Asp Gly Gly Phe Ala Phe Pro Pro Thr Glu Pro Leu Met Ser Pro 
                85                  90                  95      


Met Thr Leu Asp Glu Met Arg His Phe Tyr Lys Asp Asn Lys Tyr Val 
            100                 105                 110         


Lys Asn Leu Asp Glu Leu Thr Leu Cys Ser Arg His Ala Gly Asn Met 
        115                 120                 125             


Ile Pro Asp Asn Asp Lys Asn Ser Asn Tyr Lys Tyr Pro Ala Val Tyr 
    130                 135                 140                 


Asp Asp Lys Asp Lys Lys Cys His Ile Leu Tyr Ile Ala Ala Gln Glu 
145                 150                 155                 160 


Asn Asn Gly Pro Arg Tyr Cys Asn Lys Asp Glu Ser Lys Arg Asn Ser 
                165                 170                 175     


Met Phe Cys Phe Arg Pro Ala Lys Asp Ile Ser Phe Gln Asn Tyr Ala 
            180                 185                 190         


Tyr Leu Ser Lys Asn Val Val Asp Asn Trp Glu Lys Val Cys Pro Arg 
        195                 200                 205             


Lys Asn Leu Gln Asn Ala Lys Phe Gly Leu Trp Val Asp Gly Asn Cys 
    210                 215                 220                 


Glu Asp Ile Pro His Val Asn Glu Phe Pro Ala Ile Asp Leu Phe Glu 
225                 230                 235                 240 


Cys Asn Lys Leu Val Phe Glu Leu Ser Ala Ser Asp Gln Pro Lys Gln 
                245                 250                 255     


Tyr Glu Gln His Leu Thr Asp Tyr Glu Lys Ile Lys Glu Gly Phe Lys 
            260                 265                 270         


Asn Lys Asn Ala Ala Met Ile Lys Ser Ala Phe Leu Pro Thr Gly Ala 
        275                 280                 285             


Phe Lys Ala Asp Arg Tyr Lys Ser His Gly Lys Gly Tyr Asn Trp Gly 
    290                 295                 300                 


Asn Tyr Asn Thr Glu Thr Gln Lys Cys Glu Ile Phe Asn Val Lys Pro 
305                 310                 315                 320 


Thr Cys Leu Ile Asn Asn Ala Ala Tyr Ile Ala Thr Thr Ala Leu Ser 
                325                 330                 335     


His Pro Ile Glu Val Glu Asn Asn Phe Pro Cys Ser Leu Tyr Lys Asp 
            340                 345                 350         


Glu Ile Met Lys Glu Ile Glu Arg Glu Ser Lys Arg Ile Lys Leu Asn 
        355                 360                 365             


Asp Asn Asp Asp Glu Gly Asn Lys Lys Ile Ile Ala Pro Arg Ile Phe 
    370                 375                 380                 


Ile Ser Asp Asp Lys Asp Ser Leu Lys Cys Pro Cys Asp Pro Glu Met 
385                 390                 395                 400 


Val Ser Asn Ser Ala Cys Arg Phe Phe Val Cys Lys Cys Val Glu Arg 
                405                 410                 415     


Arg Ala Glu Val Thr Ser Asn Asn Glu Val Val Val Lys Glu Glu Tyr 
            420                 425                 430         


Lys Asp Glu Tyr Ala Asp Ile Pro Glu His Lys Pro Thr Tyr Asp Lys 
        435                 440                 445             


Met Lys Ala Ala Ala Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser 
    450                 455                 460                 


Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys 
465                 470                 475                 480 


Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
                485                 490                 495     


Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
            500                 505                 510         


Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr 
        515                 520                 525             


Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val 
    530                 535                 540                 


Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro 
545                 550                 555                 560 


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
                565                 570                 575     


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
            580                 585                 590         


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
        595                 600                 605             


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
    610                 615                 620                 


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
625                 630                 635                 640 


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
                645                 650                 655     


Ser Asn Lys Ala Phe Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
            660                 665                 670         


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
        675                 680                 685             


Asp Lys Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
    690                 695                 700                 


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
705                 710                 715                 720 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Lys Ser Asp Gly Ser 
                725                 730                 735     


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
            740                 745                 750         


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
        755                 760                 765             


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys His Met Ala Pro 
    770                 775                 780                 


Ser Asp Lys His Ile Glu Gln Tyr Leu Lys Lys Ile Gln Asn Ser Leu 
785                 790                 795                 800 


Ser Thr Glu Trp Ser Pro Cys Ser Val Thr Cys Gly Asn Gly Ile Gln 
                805                 810                 815     


Val Arg Ile Lys Pro Gly Ser Ala Asn Lys Pro Lys Asp Glu Leu Asp 
            820                 825                 830         


Tyr Glu Asn Asp Ile Glu Lys Lys Ile Cys Lys Met Glu Lys Cys Ser 
        835                 840                 845             


Ser Val Phe Asn Val Val Asn Ser Ser Ala Ala Ala His His His His 
    850                 855                 860                 


His His Ser Glu Lys Asp Glu Leu 
865                 870         


<210>  98
<211>  872
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MIA-C fusion polypeptides

<400>  98

Ile Glu Ile Val Glu Arg Ser Asn Tyr Met Gly Asn Pro Trp Thr Glu 
1               5                   10                  15      


Tyr Met Ala Lys Tyr Asp Ile Glu Glu Val His Gly Ser Gly Ile Arg 
            20                  25                  30          


Val Asp Leu Gly Glu Asp Ala Glu Val Ala Gly Thr Gln Tyr Arg Leu 
        35                  40                  45              


Pro Ser Gly Lys Cys Pro Val Phe Gly Lys Gly Ile Ile Ile Glu Asn 
    50                  55                  60                  


Ser Asn Thr Ala Phe Leu Thr Pro Val Ala Thr Gly Asn Gln Tyr Leu 
65                  70                  75                  80  


Lys Asp Gly Gly Phe Ala Phe Pro Pro Thr Glu Pro Leu Met Ser Pro 
                85                  90                  95      


Met Thr Leu Asp Glu Met Arg His Phe Tyr Lys Asp Asn Lys Tyr Val 
            100                 105                 110         


Lys Asn Leu Asp Glu Leu Thr Leu Cys Ser Arg His Ala Gly Asn Met 
        115                 120                 125             


Ile Pro Asp Asn Asp Lys Asn Ser Asn Tyr Lys Tyr Pro Ala Val Tyr 
    130                 135                 140                 


Asp Asp Lys Asp Lys Lys Cys His Ile Leu Tyr Ile Ala Ala Gln Glu 
145                 150                 155                 160 


Asn Asn Gly Pro Arg Tyr Cys Asn Lys Asp Glu Ser Lys Arg Asn Ser 
                165                 170                 175     


Met Phe Cys Phe Arg Pro Ala Lys Asp Ile Ser Phe Gln Asn Tyr Ala 
            180                 185                 190         


Tyr Leu Ser Lys Asn Val Val Asp Asn Trp Glu Lys Val Cys Pro Arg 
        195                 200                 205             


Lys Asn Leu Gln Asn Ala Lys Phe Gly Leu Trp Val Asp Gly Asn Cys 
    210                 215                 220                 


Glu Asp Ile Pro His Val Asn Glu Phe Pro Ala Ile Asp Leu Phe Glu 
225                 230                 235                 240 


Cys Asn Lys Leu Val Phe Glu Leu Ser Ala Ser Asp Gln Pro Lys Gln 
                245                 250                 255     


Tyr Glu Gln His Leu Thr Asp Tyr Glu Lys Ile Lys Glu Gly Phe Lys 
            260                 265                 270         


Asn Lys Asn Ala Ala Met Ile Lys Ser Ala Phe Leu Pro Thr Gly Ala 
        275                 280                 285             


Phe Lys Ala Asp Arg Tyr Lys Ser His Gly Lys Gly Tyr Asn Trp Gly 
    290                 295                 300                 


Asn Tyr Asn Thr Glu Thr Gln Lys Cys Glu Ile Phe Asn Val Lys Pro 
305                 310                 315                 320 


Thr Cys Leu Ile Asn Asn Ala Ala Tyr Ile Ala Thr Thr Ala Leu Ser 
                325                 330                 335     


His Pro Ile Glu Val Glu Asn Asn Phe Pro Cys Ser Leu Tyr Lys Asp 
            340                 345                 350         


Glu Ile Met Lys Glu Ile Glu Arg Glu Ser Lys Arg Ile Lys Leu Asn 
        355                 360                 365             


Asp Asn Asp Asp Glu Gly Asn Lys Lys Ile Ile Ala Pro Arg Ile Phe 
    370                 375                 380                 


Ile Ser Asp Asp Lys Asp Ser Leu Lys Cys Pro Cys Asp Pro Glu Met 
385                 390                 395                 400 


Val Ser Asn Ser Ala Cys Arg Phe Phe Val Cys Lys Cys Val Glu Arg 
                405                 410                 415     


Arg Ala Glu Val Thr Ser Asn Asn Glu Val Val Val Lys Glu Glu Tyr 
            420                 425                 430         


Lys Asp Glu Tyr Ala Asp Ile Pro Glu His Lys Pro Thr Tyr Asp Lys 
        435                 440                 445             


Met Lys Ala Ala Ala Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser 
    450                 455                 460                 


Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys 
465                 470                 475                 480 


Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
                485                 490                 495     


Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
            500                 505                 510         


Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr 
        515                 520                 525             


Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val 
    530                 535                 540                 


Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro 
545                 550                 555                 560 


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
                565                 570                 575     


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
            580                 585                 590         


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
        595                 600                 605             


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
    610                 615                 620                 


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
625                 630                 635                 640 


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
                645                 650                 655     


Ser Asn Lys Ala Phe Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
            660                 665                 670         


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
        675                 680                 685             


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
    690                 695                 700                 


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
705                 710                 715                 720 


Glu Asn Asn Tyr Asp Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
                725                 730                 735     


Phe Phe Leu Tyr Ser Asp Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
            740                 745                 750         


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
        755                 760                 765             


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys His Met Ala Pro 
    770                 775                 780                 


Ser Asp Lys His Ile Glu Gln Tyr Leu Lys Lys Ile Gln Asn Ser Leu 
785                 790                 795                 800 


Ser Thr Glu Trp Ser Pro Cys Ser Val Thr Cys Gly Asn Gly Ile Gln 
                805                 810                 815     


Val Arg Ile Lys Pro Gly Ser Ala Asn Lys Pro Lys Asp Glu Leu Asp 
            820                 825                 830         


Tyr Glu Asn Asp Ile Glu Lys Lys Ile Cys Lys Met Glu Lys Cys Ser 
        835                 840                 845             


Ser Val Phe Asn Val Val Asn Ser Ser Ala Ala Ala His His His His 
    850                 855                 860                 


His His Ser Glu Lys Asp Glu Leu 
865                 870         


<210>  99
<211>  564
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MIA-C fusion polypeptides

<400>  99

Lys Lys Tyr Glu Thr Tyr Val Asp Met Lys Thr Ile Glu Ser Lys Tyr 
1               5                   10                  15      


Thr Thr Val Met Thr Leu Ser Glu His Leu Leu Glu Tyr Ala Met Asp 
            20                  25                  30          


Val Leu Lys Ala Asn Pro Gln Lys Pro Ile Asp Pro Lys Ala Asn Leu 
        35                  40                  45              


Asp Ser Glu Val Val Lys Leu Gln Ile Lys Ile Asn Glu Lys Ser Asn 
    50                  55                  60                  


Glu Leu Asp Asn Ala Ala Ser Gln Val Lys Thr Leu Ile Ile Ile Met 
65                  70                  75                  80  


Lys Ser Phe Tyr Asp Ile Ile Ile Ser Glu Lys Ala Ser Met Asp Glu 
                85                  90                  95      


Met Glu Lys Lys Glu Leu Ser Leu Asn Asn Tyr Ile Glu Lys Thr Asp 
            100                 105                 110         


Tyr Ala Ala Ala Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser 
        115                 120                 125             


Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
    130                 135                 140                 


Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
145                 150                 155                 160 


Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
                165                 170                 175     


Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln 
            180                 185                 190         


Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp 
        195                 200                 205             


Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
    210                 215                 220                 


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
225                 230                 235                 240 


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
                245                 250                 255     


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
            260                 265                 270         


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
        275                 280                 285             


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
    290                 295                 300                 


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
305                 310                 315                 320 


Asn Lys Ala Phe Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
                325                 330                 335     


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
            340                 345                 350         


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
        355                 360                 365             


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
    370                 375                 380                 


Asn Asn Tyr Asp Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
385                 390                 395                 400 


Phe Leu Tyr Ser Asp Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
                405                 410                 415     


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
            420                 425                 430         


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys His Met Ala Glu Lys 
        435                 440                 445             


Thr Asn Lys Gly Thr Gly Ser Gly Val Ser Ser Lys Lys Lys Asn Lys 
    450                 455                 460                 


Lys Gly Ser Gly Glu Pro Leu Ile Asp Val His Asp Leu Ile Ser Asp 
465                 470                 475                 480 


Met Ile Lys Lys Glu Glu Glu Leu Val Glu Val Asn Lys Arg Lys Ser 
                485                 490                 495     


Lys Tyr Lys Leu Ala Thr Ser Asn Thr Glu Lys Gly Arg His Pro Phe 
            500                 505                 510         


Lys Ile Gly Ser Ser Asp Pro Ala Asp Asn Ala Asn Pro Asp Ala Asp 
        515                 520                 525             


Ser Glu Ser Asn Gly Glu Pro Asn Ala Asp Pro Gln Val Thr Ala Gln 
    530                 535                 540                 


Asp Val Thr Pro Glu Gln Pro Gln Gly Asp Asp Asn Asn Leu Val Ser 
545                 550                 555                 560 


Gly Pro Glu His 
                


<210>  100
<211>  507
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MIA-C fusion polypeptides

<400>  100

Lys Lys Tyr Glu Thr Tyr Val Asp Met Lys Thr Ile Glu Ser Lys Tyr 
1               5                   10                  15      


Thr Thr Val Met Thr Leu Ser Glu His Leu Leu Glu Tyr Ala Met Asp 
            20                  25                  30          


Val Leu Lys Ala Asn Pro Gln Lys Pro Ile Asp Pro Lys Ala Asn Leu 
        35                  40                  45              


Asp Ser Glu Val Val Lys Leu Gln Ile Lys Ile Asn Glu Lys Ser Asn 
    50                  55                  60                  


Glu Leu Asp Asn Ala Ala Ser Gln Val Lys Thr Leu Ile Ile Ile Met 
65                  70                  75                  80  


Lys Ser Phe Tyr Asp Ile Ile Ile Ser Glu Lys Ala Ser Met Asp Glu 
                85                  90                  95      


Met Glu Lys Lys Glu Leu Ser Leu Asn Asn Tyr Ile Glu Lys Thr Asp 
            100                 105                 110         


Tyr Ala Ala Ala Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser 
        115                 120                 125             


Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
    130                 135                 140                 


Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
145                 150                 155                 160 


Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
                165                 170                 175     


Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln 
            180                 185                 190         


Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp 
        195                 200                 205             


Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
    210                 215                 220                 


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
225                 230                 235                 240 


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
                245                 250                 255     


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
            260                 265                 270         


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
        275                 280                 285             


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
    290                 295                 300                 


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
305                 310                 315                 320 


Asn Lys Ala Phe Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
                325                 330                 335     


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
            340                 345                 350         


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
        355                 360                 365             


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
    370                 375                 380                 


Asn Asn Tyr Asp Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
385                 390                 395                 400 


Phe Leu Tyr Ser Asp Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
                405                 410                 415     


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
            420                 425                 430         


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys His Met Asp Ile Thr 
        435                 440                 445             


Gln Gln Ala Lys Asp Ile Gly Ala Gly Pro Val Ala Ser Cys Phe Thr 
    450                 455                 460                 


Thr Arg Met Ser Pro Pro Gln Gln Ile Cys Leu Asn Ser Val Val Asn 
465                 470                 475                 480 


Thr Ala Leu Ser Thr Ser Thr Gln Ser Ala Met Lys Ala Ala Ala His 
                485                 490                 495     


His His His His His Ser Glu Lys Asp Glu Leu 
            500                 505         


<210>  101
<211>  739
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MIA-C fusion polypeptides

<400>  101

Asp Ser Arg His Val Phe Ile Arg Thr Glu Leu Ser Phe Ile Lys Asn 
1               5                   10                  15      


Asn Val Pro Cys Ile Arg Asp Met Phe Phe Ile Tyr Lys Arg Glu Leu 
            20                  25                  30          


Tyr Asn Ile Cys Leu Asp Asp Leu Lys Gly Glu Glu Asp Glu Thr His 
        35                  40                  45              


Ile Tyr Val Gln Lys Lys Val Lys Asp Ser Trp Ile Thr Leu Asn Asp 
    50                  55                  60                  


Leu Phe Lys Glu Thr Asp Leu Thr Gly Arg Pro His Ile Phe Ala Tyr 
65                  70                  75                  80  


Val Asp Val Glu Glu Ile Ile Ile Leu Leu Cys Glu Asp Glu Glu Phe 
                85                  90                  95      


Ser Asn Arg Lys Lys Asp Met Thr Cys His Arg Phe Tyr Ser Asn Asp 
            100                 105                 110         


Gly Lys Glu Tyr Asn Asn Ser Glu Ile Thr Ile Ser Asp Tyr Ile Leu 
        115                 120                 125             


Lys Asp Lys Leu Leu Ser Ser Tyr Val Ser Leu Pro Leu Lys Ile Glu 
    130                 135                 140                 


Asn Arg Glu Tyr Phe Leu Ile Cys Gly Val Ser Pro Tyr Lys Phe Lys 
145                 150                 155                 160 


Asp Asp Asn Lys Lys Asp Asp Ile Leu Cys Met Ala Ser His Asp Lys 
                165                 170                 175     


Gly Glu Thr Trp Gly Thr Lys Ile Val Ile Lys Tyr Asp Asn Tyr Lys 
            180                 185                 190         


Leu Gly Val Gln Tyr Phe Phe Leu Arg Pro Tyr Ile Ser Lys Asn Asp 
        195                 200                 205             


Leu Ser Phe His Phe Tyr Val Gly Asp Asn Ile Asn Asn Val Lys Asn 
    210                 215                 220                 


Val Asn Phe Ile Glu Cys Thr His Glu Lys Asp Leu Glu Phe Val Cys 
225                 230                 235                 240 


Ser Asn Arg Asp Phe Leu Lys Asp Asn Lys Val Leu Gln Asp Val Ser 
                245                 250                 255     


Thr Leu Asn Asp Glu Tyr Ile Val Ser Tyr Gly Asn Asp Asn Asn Phe 
            260                 265                 270         


Ala Glu Cys Tyr Ile Phe Phe Asn Asn Glu Asn Ser Ile Leu Ile Lys 
        275                 280                 285             


Pro Glu Lys Tyr Gly Asn Thr Thr Ala Gly Cys Tyr Gly Gly Thr Phe 
    290                 295                 300                 


Val Lys Ile Asp Glu Asn Arg Thr Leu Phe Ile Tyr Ser Ala Ala Ala 
305                 310                 315                 320 


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
                325                 330                 335     


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
            340                 345                 350         


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
        355                 360                 365             


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
    370                 375                 380                 


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
385                 390                 395                 400 


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu 
                405                 410                 415     


Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
            420                 425                 430         


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        435                 440                 445             


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    450                 455                 460                 


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
465                 470                 475                 480 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
                485                 490                 495     


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            500                 505                 510         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Phe 
        515                 520                 525             


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    530                 535                 540                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Lys Leu Thr Lys 
545                 550                 555                 560 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                565                 570                 575     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            580                 585                 590         


Thr Thr Pro Pro Val Leu Lys Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        595                 600                 605             


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
    610                 615                 620                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
625                 630                 635                 640 


Leu Ser Leu Ser Pro Gly Lys His Met Ala Pro Ser Asp Lys His Ile 
                645                 650                 655     


Glu Gln Tyr Leu Lys Lys Ile Gln Asn Ser Leu Ser Thr Glu Trp Ser 
            660                 665                 670         


Pro Cys Ser Val Thr Cys Gly Asn Gly Ile Gln Val Arg Ile Lys Pro 
        675                 680                 685             


Gly Ser Ala Asn Lys Pro Lys Asp Glu Leu Asp Tyr Glu Asn Asp Ile 
    690                 695                 700                 


Glu Lys Lys Ile Cys Lys Met Glu Lys Cys Ser Ser Val Phe Asn Val 
705                 710                 715                 720 


Val Asn Ser Ser Ala Ala Ala His His His His His His Ser Glu Lys 
                725                 730                 735     


Asp Glu Leu 
            


<210>  102
<211>  711
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MIA-C fusion polypeptides

<400>  102

Asp Ser Arg His Val Phe Ile Arg Thr Glu Leu Ser Phe Ile Lys Asn 
1               5                   10                  15      


Asn Val Pro Cys Ile Arg Asp Met Phe Phe Ile Tyr Lys Arg Glu Leu 
            20                  25                  30          


Tyr Asn Ile Cys Leu Asp Asp Leu Lys Gly Glu Glu Asp Glu Thr His 
        35                  40                  45              


Ile Tyr Val Gln Lys Lys Val Lys Asp Ser Trp Ile Thr Leu Asn Asp 
    50                  55                  60                  


Leu Phe Lys Glu Thr Asp Leu Thr Gly Arg Pro His Ile Phe Ala Tyr 
65                  70                  75                  80  


Val Asp Val Glu Glu Ile Ile Ile Leu Leu Cys Glu Asp Glu Glu Phe 
                85                  90                  95      


Ser Asn Arg Lys Lys Asp Met Thr Cys His Arg Phe Tyr Ser Asn Asp 
            100                 105                 110         


Gly Lys Glu Tyr Asn Asn Ser Glu Ile Thr Ile Ser Asp Tyr Ile Leu 
        115                 120                 125             


Lys Asp Lys Leu Leu Ser Ser Tyr Val Ser Leu Pro Leu Lys Ile Glu 
    130                 135                 140                 


Asn Arg Glu Tyr Phe Leu Ile Cys Gly Val Ser Pro Tyr Lys Phe Lys 
145                 150                 155                 160 


Asp Asp Asn Lys Lys Asp Asp Ile Leu Cys Met Ala Ser His Asp Lys 
                165                 170                 175     


Gly Glu Thr Trp Gly Thr Lys Ile Val Ile Lys Tyr Asp Asn Tyr Lys 
            180                 185                 190         


Leu Gly Val Gln Tyr Phe Phe Leu Arg Pro Tyr Ile Ser Lys Asn Asp 
        195                 200                 205             


Leu Ser Phe His Phe Tyr Val Gly Asp Asn Ile Asn Asn Val Lys Asn 
    210                 215                 220                 


Val Asn Phe Ile Glu Cys Thr His Glu Lys Asp Leu Glu Phe Val Cys 
225                 230                 235                 240 


Ser Asn Arg Asp Phe Leu Lys Asp Asn Lys Val Leu Gln Asp Val Ser 
                245                 250                 255     


Thr Leu Asn Asp Glu Tyr Ile Val Ser Tyr Gly Asn Asp Asn Asn Phe 
            260                 265                 270         


Ala Glu Cys Tyr Ile Phe Phe Asn Asn Glu Asn Ser Ile Leu Ile Lys 
        275                 280                 285             


Pro Glu Lys Tyr Gly Asn Thr Thr Ala Gly Cys Tyr Gly Gly Thr Phe 
    290                 295                 300                 


Val Lys Ile Asp Glu Asn Arg Thr Leu Phe Ile Tyr Ser Ala Ala Ala 
305                 310                 315                 320 


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
                325                 330                 335     


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
            340                 345                 350         


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
        355                 360                 365             


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
    370                 375                 380                 


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
385                 390                 395                 400 


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu 
                405                 410                 415     


Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
            420                 425                 430         


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        435                 440                 445             


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    450                 455                 460                 


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
465                 470                 475                 480 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
                485                 490                 495     


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            500                 505                 510         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Phe 
        515                 520                 525             


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    530                 535                 540                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
545                 550                 555                 560 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                565                 570                 575     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Asp 
            580                 585                 590         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        595                 600                 605             


Asp Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
    610                 615                 620                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
625                 630                 635                 640 


Leu Ser Leu Ser Pro Gly Lys His Met Asp Ile Thr Gln Gln Ala Lys 
                645                 650                 655     


Asp Ile Gly Ala Gly Pro Val Ala Ser Cys Phe Thr Thr Arg Met Ser 
            660                 665                 670         


Pro Pro Gln Gln Ile Cys Leu Asn Ser Val Val Asn Thr Ala Leu Ser 
        675                 680                 685             


Thr Ser Thr Gln Ser Ala Met Lys Ala Ala Ala His His His His His 
    690                 695                 700                 


His Ser Glu Lys Asp Glu Leu 
705                 710     


<210>  103
<211>  695
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MIA-C fusion polypeptides

<400>  103

Asn Glu Asp Arg Gly Ile Tyr Asp Glu Leu Leu Glu Asn Asp Met Cys 
1               5                   10                  15      


Asp Leu Tyr Asn Leu Lys Met His Asp Leu His Asn Leu Lys Ser Tyr 
            20                  25                  30          


Asp Phe Gly Leu Ser Lys Asp Leu Leu Lys Lys Asp Ile Phe Ile Tyr 
        35                  40                  45              


Ser Asn Asn Leu Lys Asn Asp Asp Met Asp Asp Asp Asp Asn Asn Asn 
    50                  55                  60                  


Met Asn Asp Ile Ala Ile Gly Glu Asn Val Ile Tyr Glu Asn Asp Ile 
65                  70                  75                  80  


His Glu Asn Asn Ile Asp Asp Asn Asp Met Tyr Asn Asn Tyr Val Asn 
                85                  90                  95      


Gly Asn Asp Leu Tyr Ile Asn Asn Met Gln Asp Asp Ala Met Asp Asp 
            100                 105                 110         


Ile Val Tyr Asp Glu Glu Glu Ile Lys Ser Phe Leu Asp Lys Leu Lys 
        115                 120                 125             


Ser Asp Ile Ser Asn Gln Met Asn Val Lys Asn Gly Asn Val Glu Val 
    130                 135                 140                 


Thr Gly Asn Gly Gly Asn Glu Glu Met Ser Tyr Ile Asn Asn Asp Glu 
145                 150                 155                 160 


Asn Leu Gln Ala Phe Asp Leu Leu Asp Asn Phe His Met Asp Asp Tyr 
                165                 170                 175     


Gly Asn Asn Tyr Asn Asp Asn Glu Glu Asp Gly Asp Gly Asp Gly Asp 
            180                 185                 190         


Asp Asp Glu Gln Lys Lys Arg Lys Gln Lys Glu Leu His Asn Val Asn 
        195                 200                 205             


Gly Lys Leu Asp Leu Ser Asp Leu Asn Glu Leu Asn Val Asp Asp Ile 
    210                 215                 220                 


Asn Asn Asn Phe Tyr Met Ser Thr Pro Arg Lys Ser Ile Asp Glu Arg 
225                 230                 235                 240 


Lys Asp Thr Glu Cys Gln Thr Asp Phe Pro Leu Leu Asp Val Ser Arg 
                245                 250                 255     


Asn Thr Asp Arg Thr Pro Arg Arg Lys Ser Val Glu Val Ile Leu Val 
            260                 265                 270         


Glu Ala Ala Ala Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser 
        275                 280                 285             


Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
    290                 295                 300                 


Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
305                 310                 315                 320 


Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
                325                 330                 335     


Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln 
            340                 345                 350         


Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp 
        355                 360                 365             


Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
    370                 375                 380                 


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
385                 390                 395                 400 


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
                405                 410                 415     


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
            420                 425                 430         


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
        435                 440                 445             


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
    450                 455                 460                 


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
465                 470                 475                 480 


Asn Lys Ala Phe Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
                485                 490                 495     


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
            500                 505                 510         


Lys Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
        515                 520                 525             


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
    530                 535                 540                 


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Lys Ser Asp Gly Ser Phe 
545                 550                 555                 560 


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
                565                 570                 575     


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
            580                 585                 590         


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys His Met Ala Pro Ser 
        595                 600                 605             


Asp Lys His Ile Glu Gln Tyr Leu Lys Lys Ile Gln Asn Ser Leu Ser 
    610                 615                 620                 


Thr Glu Trp Ser Pro Cys Ser Val Thr Cys Gly Asn Gly Ile Gln Val 
625                 630                 635                 640 


Arg Ile Lys Pro Gly Ser Ala Asn Lys Pro Lys Asp Glu Leu Asp Tyr 
                645                 650                 655     


Glu Asn Asp Ile Glu Lys Lys Ile Cys Lys Met Glu Lys Cys Ser Ser 
            660                 665                 670         


Val Phe Asn Val Val Asn Ser Ser Ala Ala Ala His His His His His 
        675                 680                 685             


His Ser Glu Lys Asp Glu Leu 
    690                 695 


<210>  104
<211>  667
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MIA-C fusion polypeptides

<400>  104

Asn Glu Asp Arg Gly Ile Tyr Asp Glu Leu Leu Glu Asn Asp Met Cys 
1               5                   10                  15      


Asp Leu Tyr Asn Leu Lys Met His Asp Leu His Asn Leu Lys Ser Tyr 
            20                  25                  30          


Asp Phe Gly Leu Ser Lys Asp Leu Leu Lys Lys Asp Ile Phe Ile Tyr 
        35                  40                  45              


Ser Asn Asn Leu Lys Asn Asp Asp Met Asp Asp Asp Asp Asn Asn Asn 
    50                  55                  60                  


Met Asn Asp Ile Ala Ile Gly Glu Asn Val Ile Tyr Glu Asn Asp Ile 
65                  70                  75                  80  


His Glu Asn Asn Ile Asp Asp Asn Asp Met Tyr Asn Asn Tyr Val Asn 
                85                  90                  95      


Gly Asn Asp Leu Tyr Ile Asn Asn Met Gln Asp Asp Ala Met Asp Asp 
            100                 105                 110         


Ile Val Tyr Asp Glu Glu Glu Ile Lys Ser Phe Leu Asp Lys Leu Lys 
        115                 120                 125             


Ser Asp Ile Ser Asn Gln Met Asn Val Lys Asn Gly Asn Val Glu Val 
    130                 135                 140                 


Thr Gly Asn Gly Gly Asn Glu Glu Met Ser Tyr Ile Asn Asn Asp Glu 
145                 150                 155                 160 


Asn Leu Gln Ala Phe Asp Leu Leu Asp Asn Phe His Met Asp Asp Tyr 
                165                 170                 175     


Gly Asn Asn Tyr Asn Asp Asn Glu Glu Asp Gly Asp Gly Asp Gly Asp 
            180                 185                 190         


Asp Asp Glu Gln Lys Lys Arg Lys Gln Lys Glu Leu His Asn Val Asn 
        195                 200                 205             


Gly Lys Leu Asp Leu Ser Asp Leu Asn Glu Leu Asn Val Asp Asp Ile 
    210                 215                 220                 


Asn Asn Asn Phe Tyr Met Ser Thr Pro Arg Lys Ser Ile Asp Glu Arg 
225                 230                 235                 240 


Lys Asp Thr Glu Cys Gln Thr Asp Phe Pro Leu Leu Asp Val Ser Arg 
                245                 250                 255     


Asn Thr Asp Arg Thr Pro Arg Arg Lys Ser Val Glu Val Ile Leu Val 
            260                 265                 270         


Glu Ala Ala Ala Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser 
        275                 280                 285             


Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
    290                 295                 300                 


Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
305                 310                 315                 320 


Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
                325                 330                 335     


Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln 
            340                 345                 350         


Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp 
        355                 360                 365             


Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
    370                 375                 380                 


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
385                 390                 395                 400 


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
                405                 410                 415     


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
            420                 425                 430         


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
        435                 440                 445             


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
    450                 455                 460                 


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
465                 470                 475                 480 


Asn Lys Ala Phe Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
                485                 490                 495     


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
            500                 505                 510         


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
        515                 520                 525             


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
    530                 535                 540                 


Asn Asn Tyr Asp Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
545                 550                 555                 560 


Phe Leu Tyr Ser Asp Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
                565                 570                 575     


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
            580                 585                 590         


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys His Met Asp Ile Thr 
        595                 600                 605             


Gln Gln Ala Lys Asp Ile Gly Ala Gly Pro Val Ala Ser Cys Phe Thr 
    610                 615                 620                 


Thr Arg Met Ser Pro Pro Gln Gln Ile Cys Leu Asn Ser Val Val Asn 
625                 630                 635                 640 


Thr Ala Leu Ser Thr Ser Thr Gln Ser Ala Met Lys Ala Ala Ala His 
                645                 650                 655     


His His His His His Ser Glu Lys Asp Glu Leu 
            660                 665         


<210>  105
<211>  541
<212>  PRT
<213>  Mycobacterium tuberculosis

<400>  105

Ala Pro Lys Thr Tyr Cys Gln Glu Leu Lys Gly Thr Asp Thr Gly Gln 
1               5                   10                  15      


Ala Cys Gln Ile Gln Met Ser Asp Pro Ala Tyr Asn Ile Asn Ile Ser 
            20                  25                  30          


Leu Pro Ser Tyr Tyr Pro Asp Gln Lys Ser Leu Glu Asn Tyr Ile Ala 
        35                  40                  45              


Gln Thr Arg Asp Lys Phe Leu Ser Ala Ala Thr Ser Ser Thr Pro Arg 
    50                  55                  60                  


Glu Ala Pro Tyr Glu Leu Asn Ile Thr Ser Ala Thr Tyr Gln Ser Ala 
65                  70                  75                  80  


Ile Pro Pro Arg Gly Thr Gln Ala Val Val Leu Lys Val Tyr Gln Asn 
                85                  90                  95      


Ala Gly Gly Thr His Pro Thr Thr Thr Tyr Lys Ala Phe Asp Trp Asp 
            100                 105                 110         


Gln Ala Tyr Arg Lys Pro Ile Thr Tyr Asp Thr Leu Trp Gln Ala Asp 
        115                 120                 125             


Thr Asp Pro Leu Pro Val Val Phe Pro Ile Val Gln Gly Glu Leu Ser 
    130                 135                 140                 


Lys Gln Thr Gly Gln Gln Val Ser Ile Ala Pro Asn Ala Gly Leu Asp 
145                 150                 155                 160 


Pro Val Asn Tyr Gln Asn Phe Ala Val Thr Asn Asp Gly Val Ile Phe 
                165                 170                 175     


Phe Phe Asn Pro Gly Glu Leu Leu Pro Glu Ala Ala Gly Pro Thr Gln 
            180                 185                 190         


Val Leu Val Pro Arg Ser Ala Ile Asp Ser Met Leu Ala Ala Ala Ala 
        195                 200                 205             


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
    210                 215                 220                 


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
225                 230                 235                 240 


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
                245                 250                 255     


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
            260                 265                 270         


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
        275                 280                 285             


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu 
    290                 295                 300                 


Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
305                 310                 315                 320 


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
                325                 330                 335     


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
            340                 345                 350         


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
        355                 360                 365             


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
    370                 375                 380                 


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
385                 390                 395                 400 


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Phe 
                405                 410                 415     


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
            420                 425                 430         


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Lys Leu Thr Lys 
        435                 440                 445             


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
    450                 455                 460                 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
465                 470                 475                 480 


Thr Thr Pro Pro Val Leu Lys Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
                485                 490                 495     


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
            500                 505                 510         


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
        515                 520                 525             


Leu Ser Leu Ser Pro Gly Lys Ser Glu Lys Asp Glu Leu 
    530                 535                 540     


<210>  106
<211>  363
<212>  PRT
<213>  Hepatitis C virus

<400>  106

Gln Thr Thr Val Val Gly Gly Ser Gln Ser His Thr Val Arg Gly Leu 
1               5                   10                  15      


Thr Ser Leu Phe Ser Pro Gly Ala Ser Gln Asn Ala Ala Ala Lys Gly 
            20                  25                  30          


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
        35                  40                  45              


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
    50                  55                  60                  


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
65                  70                  75                  80  


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
                85                  90                  95      


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
            100                 105                 110         


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys 
        115                 120                 125             


Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
    130                 135                 140                 


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
145                 150                 155                 160 


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
                165                 170                 175     


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
            180                 185                 190         


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
        195                 200                 205             


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
    210                 215                 220                 


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Phe Pro Ala 
225                 230                 235                 240 


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
                245                 250                 255     


Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
            260                 265                 270         


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
        275                 280                 285             


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Asp Thr Thr 
    290                 295                 300                 


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Asp Leu 
305                 310                 315                 320 


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
                325                 330                 335     


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
            340                 345                 350         


Leu Ser Pro Gly Lys Ser Glu Lys Asp Glu Leu 
        355                 360             


<210>  107
<211>  513
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  malaria (CLCT) and HIV (eldkwa)

<400>  107

Phe Arg Gly Asn Asn Gly His Asp Ser Ser Ser Ser Leu Tyr Gly Gly 
1               5                   10                  15      


Ser Gln Phe Ile Glu Gln Leu Asp Asn Ser Phe Thr Ser Ala Phe Leu 
            20                  25                  30          


Glu Ser Gln Ser Met Asn Lys Ile Gly Asp Asp Leu Ala Glu Thr Ile 
        35                  40                  45              


Ser Asn Glu Leu Val Ser Val Leu Gln Lys Asn Ser Pro Thr Phe Leu 
    50                  55                  60                  


Glu Ser Ser Phe Asp Ile Lys Ser Glu Val Lys Lys His Ala Lys Ser 
65                  70                  75                  80  


Met Leu Lys Glu Leu Ile Lys Val Gly Leu Pro Ser Phe Glu Asn Leu 
                85                  90                  95      


Val Ala Glu Asn Val Lys Pro Pro Lys Val Asp Pro Ala Thr Tyr Gly 
            100                 105                 110         


Ile Ile Val Pro Val Leu Thr Ser Leu Phe Asn Lys Val Glu Thr Ala 
        115                 120                 125             


Val Gly Ala Lys Val Ser Asp Glu Ile Trp Asn Tyr Asn Ser Pro Asp 
    130                 135                 140                 


Val Ser Glu Ser Glu Glu Ser Leu Ser Asp Asp Phe Phe Asp Ala Ala 
145                 150                 155                 160 


Gly Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala 
                165                 170                 175     


Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala 
            180                 185                 190         


Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala 
        195                 200                 205             


Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala 
    210                 215                 220                 


Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn Lys Asn Asn Gln Gly 
225                 230                 235                 240 


Asn Gly Gln Gly His Asn Met Pro Asn Asp Pro Asn Arg Asn Val Asp 
                245                 250                 255     


Glu Asn Ala Asn Ala Asn Ser Ala Val Lys Asn Asn Asn Asn Glu Glu 
            260                 265                 270         


Pro Ser Asp Lys His Ile Glu Gln Tyr Leu Lys Lys Ile Gln Asn Ser 
        275                 280                 285             


Leu Ser Thr Glu Trp Ser Pro Cys Ser Val Thr Cys Gly Asn Gly Ile 
    290                 295                 300                 


Gln Val Arg Ile Lys Pro Gly Ser Ala Asn Lys Pro Lys Asp Glu Leu 
305                 310                 315                 320 


Asp Tyr Glu Asn Asp Ile Glu Lys Lys Ile Cys Lys Met Glu Lys Cys 
                325                 330                 335     


Ser Ser Val Phe Asn Val Val Asn Ser Ala Ala Val Ala Met Ala Glu 
            340                 345                 350         


Lys Thr Ala Ser Cys Gly Val Trp Asp Glu Trp Ser Pro Cys Ser Val 
        355                 360                 365             


Thr Cys Gly Lys Gly Thr Arg Ser Arg Lys Arg Glu Ile Leu His Glu 
    370                 375                 380                 


Gly Cys Thr Ser Glu Leu Gln Glu Gln Cys Glu Glu Glu Arg Cys Leu 
385                 390                 395                 400 


Pro Lys Ala Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
                405                 410                 415     


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            420                 425                 430         


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        435                 440                 445             


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    450                 455                 460                 


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
465                 470                 475                 480 


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                485                 490                 495     


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Glu Leu Asp Lys Trp 
            500                 505                 510         


Ala 
    


