                         SEQUENCE LISTING

<110>  Universit de Nice et al.
 
<120>  Cell differentiation or reprogramming using FEZF2 and LMO4.

<130>  B2133PC00

<160>  13    

<170>  PatentIn version 3.5

<210>  1
<211>  2095
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (296)..(1675)

<400>  1
cttttaaagt ttgaggggcg gtggtggcgg cggccggcag gcgcggggga acacaggggc       60

cgctacggga gccgcgccgc cgcccatgtc attccacttc aagtgacttc atgtgatgtc      120

agctgaatgt aaaagacagt gatctcacgc ggaggggaag atgtttgcca tcaaaatgtg      180

acagaagaga cacgctgcat ggctcggaac gcatctcctt ggtggtgggg gaaagagact      240

tagaggagag aggctgcgcc ctggcccagc ctggctcggc tcagctccgc gcgcc atg       298
                                                             Met          
                                                             1            

gca agc tcg gct tcc ctg gag acc atg gtg ccc ccg gcc tgc ccg cgc        346
Ala Ser Ser Ala Ser Leu Glu Thr Met Val Pro Pro Ala Cys Pro Arg           
            5                   10                  15                    

gcc gga gcg tcg ccg gcc act tcc aag aca ctg gcc ttt tcc atc gag        394
Ala Gly Ala Ser Pro Ala Thr Ser Lys Thr Leu Ala Phe Ser Ile Glu           
        20                  25                  30                        

cgc atc atg gcc aag acg tcg gag ccc cgt gcg ccc ttt gag ccc cgg        442
Arg Ile Met Ala Lys Thr Ser Glu Pro Arg Ala Pro Phe Glu Pro Arg           
    35                  40                  45                            

cct gga gcg cta gag gcg gac ggc agc cag ggc aag aaa ctg ctc aac        490
Pro Gly Ala Leu Glu Ala Asp Gly Ser Gln Gly Lys Lys Leu Leu Asn           
50                  55                  60                  65            

ctc tgc tcg ccg ctg ccc tgt atg atc ccc ctc cag ccc cta ggc tac        538
Leu Cys Ser Pro Leu Pro Cys Met Ile Pro Leu Gln Pro Leu Gly Tyr           
                70                  75                  80                

gag gtg ccg tca aag aca ctg ctc agt tac tcg gag ctc tgg aaa agc        586
Glu Val Pro Ser Lys Thr Leu Leu Ser Tyr Ser Glu Leu Trp Lys Ser           
            85                  90                  95                    

agc ctc cgg gcg ggc ggc ggc gga ggc ggc ggc ggc ggt ggc ggc ggc        634
Ser Leu Arg Ala Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly           
        100                 105                 110                       

ggc ggc ggg ggg gcc cca gtg tgc ggc gcc agc ggc ttg tgc aaa acc        682
Gly Gly Gly Gly Ala Pro Val Cys Gly Ala Ser Gly Leu Cys Lys Thr           
    115                 120                 125                           

aac tgt ggc gtg tgc tgc aag gcc gag ctg ggc ctg gcg ccg tcc gcg        730
Asn Cys Gly Val Cys Cys Lys Ala Glu Leu Gly Leu Ala Pro Ser Ala           
130                 135                 140                 145           

ctg ccc gcg ggc agg gtc atc aag ccg cag gtc atc aac cag gct gtg        778
Leu Pro Ala Gly Arg Val Ile Lys Pro Gln Val Ile Asn Gln Ala Val           
                150                 155                 160               

ggg ctg ccg gcc agc ggc tcg ctc tac tac ttc aac tac ctg gac tcg        826
Gly Leu Pro Ala Ser Gly Ser Leu Tyr Tyr Phe Asn Tyr Leu Asp Ser           
            165                 170                 175                   

acc gcg tac ccg ccg tct gag ctc ctc agc ggc cac ctc ttc ccg tct        874
Thr Ala Tyr Pro Pro Ser Glu Leu Leu Ser Gly His Leu Phe Pro Ser           
        180                 185                 190                       

ggc ctc ctc aat gcg cag gcc ccc gcc gcc ctg gct gct cac ccc aag        922
Gly Leu Leu Asn Ala Gln Ala Pro Ala Ala Leu Ala Ala His Pro Lys           
    195                 200                 205                           

ctc ttt ctg ctg gag aac gcc aag ctg gcc ggc ctg gct gcg gac aag        970
Leu Phe Leu Leu Glu Asn Ala Lys Leu Ala Gly Leu Ala Ala Asp Lys           
210                 215                 220                 225           

ttc ccc cac ccg gct ccc tat ccc cat aag gag cgc ttg ccg gcg ccg       1018
Phe Pro His Pro Ala Pro Tyr Pro His Lys Glu Arg Leu Pro Ala Pro           
                230                 235                 240               

ctg gag cag gta ctg aag gaa aac tcg gcc ctg act gcc gag cgc gga       1066
Leu Glu Gln Val Leu Lys Glu Asn Ser Ala Leu Thr Ala Glu Arg Gly           
            245                 250                 255                   

ggc gtc aag ggc cac agc aag ctg cca gga ggc tcc gca gat ggc aag       1114
Gly Val Lys Gly His Ser Lys Leu Pro Gly Gly Ser Ala Asp Gly Lys           
        260                 265                 270                       

ccc aaa aac ttc acc tgc gag gtg tgc ggc aag gtg ttt aac gct cac       1162
Pro Lys Asn Phe Thr Cys Glu Val Cys Gly Lys Val Phe Asn Ala His           
    275                 280                 285                           

tat aat ctc acc cgc cac atg ccg gtc cac acc gga gcc aga ccg ttc       1210
Tyr Asn Leu Thr Arg His Met Pro Val His Thr Gly Ala Arg Pro Phe           
290                 295                 300                 305           

gtg tgc aaa gtc tgc ggc aaa ggc ttt cgc cag gcc agc acg ctc tgc       1258
Val Cys Lys Val Cys Gly Lys Gly Phe Arg Gln Ala Ser Thr Leu Cys           
                310                 315                 320               

agg cac aaa att atc cac acc cag gaa aag cca cat aaa tgc aac cag       1306
Arg His Lys Ile Ile His Thr Gln Glu Lys Pro His Lys Cys Asn Gln           
            325                 330                 335                   

tgc ggc aaa gcg ttc aac cgc agc tcc acg ctc aac acg cat atc cgc       1354
Cys Gly Lys Ala Phe Asn Arg Ser Ser Thr Leu Asn Thr His Ile Arg           
        340                 345                 350                       

atc cac gcg ggc tac aag ccc ttc gtc tgc gaa ttt tgc ggc aaa ggc       1402
Ile His Ala Gly Tyr Lys Pro Phe Val Cys Glu Phe Cys Gly Lys Gly           
    355                 360                 365                           

ttt cac caa aaa ggg aac tac aag aac cac aag ctg acc cac agc ggc       1450
Phe His Gln Lys Gly Asn Tyr Lys Asn His Lys Leu Thr His Ser Gly           
370                 375                 380                 385           

gag aag cag tac aaa tgt acc atc tgc aac aag gcc ttc cac cag gtc       1498
Glu Lys Gln Tyr Lys Cys Thr Ile Cys Asn Lys Ala Phe His Gln Val           
                390                 395                 400               

tac aac cta acc ttc cat atg cac acc cac aac gac aag aag cct ttc       1546
Tyr Asn Leu Thr Phe His Met His Thr His Asn Asp Lys Lys Pro Phe           
            405                 410                 415                   

acg tgc gcc act tgc ggc aaa ggg ttt tgc aga aac ttt gac tta aag       1594
Thr Cys Ala Thr Cys Gly Lys Gly Phe Cys Arg Asn Phe Asp Leu Lys           
        420                 425                 430                       

aaa cat gtg cgc aaa ctc cac gac agc gtg ggc cct gct gcc ccc tcc       1642
Lys His Val Arg Lys Leu His Asp Ser Val Gly Pro Ala Ala Pro Ser           
    435                 440                 445                           

gca aag gac ctg act agg aca gtg cag agc tga gagctactgc cttgcccttc     1695
Ala Lys Asp Leu Thr Arg Thr Val Gln Ser                                   
450                 455                                                   

cttccctccc tgtaccacct gaaaacagat cacacatata aacttatttc taaaattaaa     1755

agaaaaaaaa actatagcag agaggctaaa atctatttat cgaaaccagc atatttttgg     1815

aaagctaaat gtttcctcga tgactggcag caaactcgtg gcccccacct ttgtatattc     1875

aggaaactta tttaaatcca gtgcgccgaa acgtatttaa ttccaggcct ccgcttctcc     1935

tggggcagcc agttttaacc ccagcctgtc accgtgagcg ccccagaaga gcgcggcgcc     1995

cctagccatc tttatacagc catgtaaatc ctcctgtaca agcgaacacg gaatatatac     2055

atatataact caataaacag aatcattagt gaaaaaaaaa                           2095


<210>  2
<211>  459
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ala Ser Ser Ala Ser Leu Glu Thr Met Val Pro Pro Ala Cys Pro 
1               5                   10                  15      


Arg Ala Gly Ala Ser Pro Ala Thr Ser Lys Thr Leu Ala Phe Ser Ile 
            20                  25                  30          


Glu Arg Ile Met Ala Lys Thr Ser Glu Pro Arg Ala Pro Phe Glu Pro 
        35                  40                  45              


Arg Pro Gly Ala Leu Glu Ala Asp Gly Ser Gln Gly Lys Lys Leu Leu 
    50                  55                  60                  


Asn Leu Cys Ser Pro Leu Pro Cys Met Ile Pro Leu Gln Pro Leu Gly 
65                  70                  75                  80  


Tyr Glu Val Pro Ser Lys Thr Leu Leu Ser Tyr Ser Glu Leu Trp Lys 
                85                  90                  95      


Ser Ser Leu Arg Ala Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly 
            100                 105                 110         


Gly Gly Gly Gly Gly Ala Pro Val Cys Gly Ala Ser Gly Leu Cys Lys 
        115                 120                 125             


Thr Asn Cys Gly Val Cys Cys Lys Ala Glu Leu Gly Leu Ala Pro Ser 
    130                 135                 140                 


Ala Leu Pro Ala Gly Arg Val Ile Lys Pro Gln Val Ile Asn Gln Ala 
145                 150                 155                 160 


Val Gly Leu Pro Ala Ser Gly Ser Leu Tyr Tyr Phe Asn Tyr Leu Asp 
                165                 170                 175     


Ser Thr Ala Tyr Pro Pro Ser Glu Leu Leu Ser Gly His Leu Phe Pro 
            180                 185                 190         


Ser Gly Leu Leu Asn Ala Gln Ala Pro Ala Ala Leu Ala Ala His Pro 
        195                 200                 205             


Lys Leu Phe Leu Leu Glu Asn Ala Lys Leu Ala Gly Leu Ala Ala Asp 
    210                 215                 220                 


Lys Phe Pro His Pro Ala Pro Tyr Pro His Lys Glu Arg Leu Pro Ala 
225                 230                 235                 240 


Pro Leu Glu Gln Val Leu Lys Glu Asn Ser Ala Leu Thr Ala Glu Arg 
                245                 250                 255     


Gly Gly Val Lys Gly His Ser Lys Leu Pro Gly Gly Ser Ala Asp Gly 
            260                 265                 270         


Lys Pro Lys Asn Phe Thr Cys Glu Val Cys Gly Lys Val Phe Asn Ala 
        275                 280                 285             


His Tyr Asn Leu Thr Arg His Met Pro Val His Thr Gly Ala Arg Pro 
    290                 295                 300                 


Phe Val Cys Lys Val Cys Gly Lys Gly Phe Arg Gln Ala Ser Thr Leu 
305                 310                 315                 320 


Cys Arg His Lys Ile Ile His Thr Gln Glu Lys Pro His Lys Cys Asn 
                325                 330                 335     


Gln Cys Gly Lys Ala Phe Asn Arg Ser Ser Thr Leu Asn Thr His Ile 
            340                 345                 350         


Arg Ile His Ala Gly Tyr Lys Pro Phe Val Cys Glu Phe Cys Gly Lys 
        355                 360                 365             


Gly Phe His Gln Lys Gly Asn Tyr Lys Asn His Lys Leu Thr His Ser 
    370                 375                 380                 


Gly Glu Lys Gln Tyr Lys Cys Thr Ile Cys Asn Lys Ala Phe His Gln 
385                 390                 395                 400 


Val Tyr Asn Leu Thr Phe His Met His Thr His Asn Asp Lys Lys Pro 
                405                 410                 415     


Phe Thr Cys Ala Thr Cys Gly Lys Gly Phe Cys Arg Asn Phe Asp Leu 
            420                 425                 430         


Lys Lys His Val Arg Lys Leu His Asp Ser Val Gly Pro Ala Ala Pro 
        435                 440                 445             


Ser Ala Lys Asp Leu Thr Arg Thr Val Gln Ser 
    450                 455                 


<210>  3
<211>  5415
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (781)..(1278)

<400>  3
gctctgtcag taacacatgt gtaagagccg cggagggagc gagcgagccg gctagaggcc       60

agcgccgccg ccgccgccgc ctccgagccg ggcagcaaca gccccggcag cggcgcaggc      120

tccagcgcgc cgggcccggc cggccgcagc ccccgacgcc tgggtgcgcc tgcctgccgg      180

cctccgcacc gtccgccgcc gctcccgggg ctgttgtgtc tgcgactgct cccggccgga      240

ggtgcaggga gctcagccga gccgccgctg ccatcccgga gcgagcaagc gagcgagcgc      300

gcgggaggga ggaaggcggc ggcggaggag gaggaggagc gggaggagcg cgggcggggg      360

cgggggcccc cgggcggggg aatatacaaa gtgaagccac attgccaaac ttgcagcagc      420

gattgcagca gttgctgccg ctgcgccgcg cctgaagccg cgccgcgcgg gccgagggct      480

cctgcagctg ctcgcgcgca gtcggaggcg gagaaggacg aagactgaga ctgacacttc      540

tgctcccggc cgcccggcac ttacgcgggg gccccccaac ccgccccaga gcaacgcgat      600

ttaaaaaaaa aaaaaaagcc gcccttagcc ccctcctccc ctttcctgct tctgcgagaa      660

ctccctccct ccctccagct ccgccagccc aggcgcccct tccctggaag ccgagcggct      720

tcgctcgcat ttcaccgccg ccgcctctcg caatattgca atatagggga aaagcagacc      780

atg gtg aat ccg ggc agc agc tcg cag ccg ccc ccg gtg acg gcc ggc        828
Met Val Asn Pro Gly Ser Ser Ser Gln Pro Pro Pro Val Thr Ala Gly           
1               5                   10                  15                

tcc ctc tcc tgg aag cgg tgc gca ggc tgc ggg ggc aag att gcg gac        876
Ser Leu Ser Trp Lys Arg Cys Ala Gly Cys Gly Gly Lys Ile Ala Asp           
            20                  25                  30                    

cgc ttt ctg ctc tat gcc atg gac agc tat tgg cac agc cgg tgc ctc        924
Arg Phe Leu Leu Tyr Ala Met Asp Ser Tyr Trp His Ser Arg Cys Leu           
        35                  40                  45                        

aag tgc tcc tgc tgc cag gcg cag ctg ggc gac atc ggc acg tcc tgt        972
Lys Cys Ser Cys Cys Gln Ala Gln Leu Gly Asp Ile Gly Thr Ser Cys           
    50                  55                  60                            

tac acc aaa agt ggc atg atc ctt tgc aga aat gac tac att agg tta       1020
Tyr Thr Lys Ser Gly Met Ile Leu Cys Arg Asn Asp Tyr Ile Arg Leu           
65                  70                  75                  80            

ttt gga aat agc ggt gct tgc agc gct tgc gga cag tcg att cct gcg       1068
Phe Gly Asn Ser Gly Ala Cys Ser Ala Cys Gly Gln Ser Ile Pro Ala           
                85                  90                  95                

agt gaa ctc gtc atg agg gcg caa ggc aat gtg tat cat ctt aag tgt       1116
Ser Glu Leu Val Met Arg Ala Gln Gly Asn Val Tyr His Leu Lys Cys           
            100                 105                 110                   

ttt aca tgc tct acc tgc cgg aat cgc ctg gtc ccg gga gat cgg ttt       1164
Phe Thr Cys Ser Thr Cys Arg Asn Arg Leu Val Pro Gly Asp Arg Phe           
        115                 120                 125                       

cac tac atc aat ggc agt tta ttt tgt gaa cat gat aga cct aca gct       1212
His Tyr Ile Asn Gly Ser Leu Phe Cys Glu His Asp Arg Pro Thr Ala           
    130                 135                 140                           

ctc atc aat ggc cat ttg aat tca ctt cag agc aat cca cta ctg cca       1260
Leu Ile Asn Gly His Leu Asn Ser Leu Gln Ser Asn Pro Leu Leu Pro           
145                 150                 155                 160           

gac cag aag gtc tgc taa aaggtcagag taatgcagaa tgcgtgcctt              1308
Asp Gln Lys Val Cys                                                       
                165                                                       

catctcagat ttgttcatca caggtggatc ccatgtgtct tcagtagaca agtcaccttt     1368

gtagctagca ccagtgccag ctccatgcca ttgcaccttc tttagtcttg attgcccttc     1428

ccgcatttat tggtgtatta aaatgactga atatgaacat taaggactcc atgaacctgg     1488

gctaatggga gactgtagag aaaatgaaaa aagatccacc agaggacatc ttggggaggg     1548

ggagggagct gggggggagg gaaatgacta atgaagctaa ttaaaagaag cattcaaatc     1608

tgctttctac cctcattaac aattagcagg gcactggcca gagtttgtac cctgtgtttt     1668

accttaacaa cattctattt gctctttgta tatttaagtg ttgtaaggaa acgtgtttca     1728

atcaaaactg accatgagat aaaggaaaga gatgtggctt ttgtgatatt ctatcacaaa     1788

cacttattgt atctctgtaa aatacaatgt atgtatgcat gtaagtgttt ttgtcctaat     1848

gttgctactc ccatggcaaa gaaaaaaaaa agaatgaaaa aaagaaaaaa atttggaaaa     1908

aaaaatcagg ctcatagcag ctactgtgta gaaaattccc cctacttcta atttgctgaa     1968

tgaagaaaaa aaaaaatctt ttatttgtga tattttcaga gacatttgct ctagtatggt     2028

gtatttaaat aataaaaact taaaagaaaa aatatttaat ggtgtttggg tttaaacact     2088

gctttttctc ttctgtattt tgaagaaatt tagtttttat tgttgttgaa taacaagctc     2148

actttaaatt tgaaggagtt gagggaggtg gagtgtatat ttatttagct ctgggccagt     2208

aaggtattct tcaaattact taaccacgcc attattggca ggggtacaaa gtagtttcta     2268

acagggtcct ttctataagt caagaatatt ctgttaacag catttcgtta cacttctata     2328

tcacagtaag tcttttgtgt ttataaatac ttgagtgtcc actattttgt ttattctttt     2388

tctcaatagc aaacaaagcc ttgggtattg atgaaaagta tgtataaaaa aaaatacggc     2448

acaaccatcc tgttctctta ttgagtttat agcttttgaa ggaagtcaca atttctaagt     2508

catacctgta catattttga agctcactta gttgtaggga cccagagctc tttttttatg     2568

gtgatctttg attggtgaag tagccatttc ctggtgaccc ttaggctcgt gtggttggct     2628

gtaaggtgtt tattttgttt tgctcctaca cttctttact gactgcgttt ccgtatgtat     2688

tttgggggaa gattctgact tcatttagtc ttagtcttga gatactgagt tgctggttgc     2748

aggcagcaga gtgtccacca cagtgcctgc actgcccgca gagctgccct ccggaaagca     2808

tgcagtataa cagctagtgc tggaaggagg aaaaccaaat aggcctggag gctgaggttg     2868

tactgccagc ttccttagat gtgagcaaat ttcaactaca acttccatca caggctaata     2928

aaaccaggtg tgtgaacgct actattttaa attttctttt ttaagatggc attttatttt     2988

gttccagaaa agcgcctgat gtagaccctc cctctgagaa tagccgtgga gccatgtaga     3048

gaggtgtagc tcagcacatc tcaactacca gtcagcttcc ctttgagaac ttctgtgctc     3108

acttcctgtt ttcagagatt ccagggcagg ggaaaaaaaa aatcagttga acttcaaacc     3168

tcctagagga gattgtaaag gcatagagtt gaggtgaata gttttgttag aaccttataa     3228

aaataaaatg caagaaaata atatgaagaa atcacatata tatgtttgaa ttagatgtct     3288

gtttgaatta gatccttggg gaatttcttc aaactagttc tggttcttat atttgttttt     3348

tttcctttaa ggaactttct gaaggaagtt agactgcgat ggtaaagggg gaaatgggtt     3408

aatgagattg caggcatttt ctatattctt tttggcataa gcacttatgt ccctgatatg     3468

tacaaattca aaggaggtgg ttaataactt tagtaaataa tatattgtcg catttaatga     3528

tgtggagggc taaggtcatt acggacttta aataaactat tatatggctg gttcctcaag     3588

cactgctgcg tatttaataa tgagcttcta aaagcatttc ttaagttgca gacctataag     3648

attacaaatg tcactcatgt tagtataatc cacatgcaag tgatgaagcc ttctctttga     3708

tgtgctaaat tggagaagga ctaatggagc tatgaatata caatagaaca tatttaagta     3768

gtagtcttgc tttaggtaaa acactttctt gaaaccagag gcatttcaaa caataaaacc     3828

cggctctaat ggggatgctc tgtgtggata gaaagctact aaaaacactc aggtttattc     3888

tgatgtgagc agcgattgtg tgcagttcct cccccaatct caacattgct taggaaaaaa     3948

aaaaatctat gagtttattc cacctttcat ccattgcatt tgtgatgtta ttagttagca     4008

agatggacac tgttctttag aaaggactta tttaatatta accacgtcat agagcaagat     4068

ggcccccagt ccctacaagc aagtgcaatt aaaaataaaa gcaaatgtta ctgagccctg     4128

ctgaactcct gataaaaaaa attatgttta tggtacatat aaatgtctca atcatgcaaa     4188

ttgtcactct tgttaatgaa acaattttgt aaaaagatag tcctctaaaa gggtttaatg     4248

ttttttacct atctaactgt ctaattagat ttacacatcc cgcaaggcag gggagcctga     4308

agcttttcca aaccaaatcg tttgccacta gaaactattt tcagctcttc atgatttatt     4368

aggaaatagt ttaacccgga ctgtagtgtc ttataaaata caaaacgaga aaactgacac     4428

accaaaatga agtctgtgaa attgtcatcc tcttaatatt acctgtattt aaattctttc     4488

ttttgccctt attaacactg atatttgaaa caactaatca tctaaaagga agctcttaaa     4548

gggctttaaa tgtcaatata gtaagattct aatgtgcact actatttata taaaatattt     4608

cttagggccc ataaatcata taataaacag tgaacccaag agctacatat ggagtctagt     4668

gaagagttcc catgtagcct aactaattgt atttaaattg aggagatcca aaaaccccat     4728

cacccttcac cccaaagacc ccttcaccct tcaccaggga attctatcct gggtgctgtc     4788

ccacctatga ccccttcaag aggccattgg aaaaaggcca tttacaagtt aatgttactt     4848

atagctttgt tactaagact cacctattgt tagtgcagcc aagtcacaga agtgcttatt     4908

gcagttaaat agcaatttgt ttccatgaaa ctgcaattaa agtattactg agcagccatt     4968

ttagattggc agtgctctga acgcatgtta aacagccagc tactcccact tgcagagtct     5028

gagatctgac tagcagcaaa gtgtagcaca ttcgccgatg ctgggtacct agttaaagag     5088

gcatttgtag ccctctgctc ccatcgtgaa catgctgaga gcaatgacaa gtcagggctg     5148

atttttggaa ggtgaacttg caacttacct caagtgaata ctgttttcag ttgtgcaaga     5208

agtgctttat gctagtagat atgtgcatgt ttcctagagg gaatgttttc aagttcagat     5268

tgattctgct gagaatggac ggcaactcgg aggcctcaag ccaataatgt actacaggcc     5328

ctgacatgtt acagctgtgt aaacagggcc attctatttc ctaaatcaca actaataaag     5388

cagaggatga aaatcaaaaa aaaaaaa                                         5415


<210>  4
<211>  165
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Val Asn Pro Gly Ser Ser Ser Gln Pro Pro Pro Val Thr Ala Gly 
1               5                   10                  15      


Ser Leu Ser Trp Lys Arg Cys Ala Gly Cys Gly Gly Lys Ile Ala Asp 
            20                  25                  30          


Arg Phe Leu Leu Tyr Ala Met Asp Ser Tyr Trp His Ser Arg Cys Leu 
        35                  40                  45              


Lys Cys Ser Cys Cys Gln Ala Gln Leu Gly Asp Ile Gly Thr Ser Cys 
    50                  55                  60                  


Tyr Thr Lys Ser Gly Met Ile Leu Cys Arg Asn Asp Tyr Ile Arg Leu 
65                  70                  75                  80  


Phe Gly Asn Ser Gly Ala Cys Ser Ala Cys Gly Gln Ser Ile Pro Ala 
                85                  90                  95      


Ser Glu Leu Val Met Arg Ala Gln Gly Asn Val Tyr His Leu Lys Cys 
            100                 105                 110         


Phe Thr Cys Ser Thr Cys Arg Asn Arg Leu Val Pro Gly Asp Arg Phe 
        115                 120                 125             


His Tyr Ile Asn Gly Ser Leu Phe Cys Glu His Asp Arg Pro Thr Ala 
    130                 135                 140                 


Leu Ile Asn Gly His Leu Asn Ser Leu Gln Ser Asn Pro Leu Leu Pro 
145                 150                 155                 160 


Asp Gln Lys Val Cys 
                165 


<210>  5
<211>  2370
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (328)..(1146)

<400>  5
cgcagccact gaaccacaag cagcttcgcg ttaactggag tgcctgggag tcgcgtgcca       60

ggagccgcac ggccagggac tgactgacag acagacacgc accaccacca caacacacga      120

gacccgggcg ggccgccgcc gccgccgccg gggctcttgg caaactcgcc ggtcgcagag      180

gtcccccgcg gagctgcgcc acagtagcgc cgggcttgca gctttcacgc cgggcgaagg      240

acccggcgct gcgctcgcag ctgcgcggag attcccggca caggccaaag tcacagcaac      300

gctgaggcac agttagagcc aactaag atg ttc gtc aaa tcc gag acc ttg gag      354
                              Met Phe Val Lys Ser Glu Thr Leu Glu         
                              1               5                           

ttg aag gag gaa gag gac gtg tta gtg ctg ctc gga tcg gcc tcc ccc        402
Leu Lys Glu Glu Glu Asp Val Leu Val Leu Leu Gly Ser Ala Ser Pro           
10                  15                  20                  25            

gcc ttg gcg gcc ctg acc ccg ctg tca tcc agc gcc gac gaa gaa gag        450
Ala Leu Ala Ala Leu Thr Pro Leu Ser Ser Ser Ala Asp Glu Glu Glu           
                30                  35                  40                

gag gag gag ccg ggc gcg tca ggc ggg gcg cgt cgg cag cgc ggg gct        498
Glu Glu Glu Pro Gly Ala Ser Gly Gly Ala Arg Arg Gln Arg Gly Ala           
            45                  50                  55                    

gag gcc ggg cag ggg gcg cgg ggc ggc gtg gct gcg ggt gcg gag ggc        546
Glu Ala Gly Gln Gly Ala Arg Gly Gly Val Ala Ala Gly Ala Glu Gly           
        60                  65                  70                        

tgc cgg ccc gca cgg ctg ctg ggt ctg gta cac gat tgc aaa cgg cgc        594
Cys Arg Pro Ala Arg Leu Leu Gly Leu Val His Asp Cys Lys Arg Arg           
    75                  80                  85                            

cct tcc cgg gcg cgg gcc gtc tcc cga ggc gcc aag acg gcc gag acg        642
Pro Ser Arg Ala Arg Ala Val Ser Arg Gly Ala Lys Thr Ala Glu Thr           
90                  95                  100                 105           

gtg cag cgc atc aag aag acc cgt aga ctg aag gcc aac aac cgc gag        690
Val Gln Arg Ile Lys Lys Thr Arg Arg Leu Lys Ala Asn Asn Arg Glu           
                110                 115                 120               

cga aac cgc atg cac aac ctc aac gcg gca ctg gac gcg ctg cgc gag        738
Arg Asn Arg Met His Asn Leu Asn Ala Ala Leu Asp Ala Leu Arg Glu           
            125                 130                 135                   

gtg ctc ccc acg ttc ccc gag gac gcc aag ctc acc aag atc gag acc        786
Val Leu Pro Thr Phe Pro Glu Asp Ala Lys Leu Thr Lys Ile Glu Thr           
        140                 145                 150                       

ctg cgc ttc gcc cac aac tac atc tgg gca ctc acc gag acc ctg cgc        834
Leu Arg Phe Ala His Asn Tyr Ile Trp Ala Leu Thr Glu Thr Leu Arg           
    155                 160                 165                           

ctg gcg gat cac tgc ggg ggc ggc ggc ggg ggc ctg ccg ggg gcg ctc        882
Leu Ala Asp His Cys Gly Gly Gly Gly Gly Gly Leu Pro Gly Ala Leu           
170                 175                 180                 185           

ttc tcc gag gca gtg ttg ctg agc ccg gga gga gcc agc gcc gcc ctg        930
Phe Ser Glu Ala Val Leu Leu Ser Pro Gly Gly Ala Ser Ala Ala Leu           
                190                 195                 200               

agc agc agc gga gac agc ccc tcg ccc gcc tcc acg tgg agt tgc acc        978
Ser Ser Ser Gly Asp Ser Pro Ser Pro Ala Ser Thr Trp Ser Cys Thr           
            205                 210                 215                   

aac agc ccc gcg ccg tcc tcc tcc gtg tcc tcc aat tcc acc tcc ccc       1026
Asn Ser Pro Ala Pro Ser Ser Ser Val Ser Ser Asn Ser Thr Ser Pro           
        220                 225                 230                       

tac agc tgc act tta tcg ccc gcc agc ccg gcc ggg tca gac atg gac       1074
Tyr Ser Cys Thr Leu Ser Pro Ala Ser Pro Ala Gly Ser Asp Met Asp           
    235                 240                 245                           

tat tgg cag ccc cca cct ccc gac aag cac cgc tat gca cct cac ctc       1122
Tyr Trp Gln Pro Pro Pro Pro Asp Lys His Arg Tyr Ala Pro His Leu           
250                 255                 260                 265           

ccc ata gcc agg gat tgt atc tag agctgccatt tctgctaccc acgccaggcc      1176
Pro Ile Ala Arg Asp Cys Ile                                               
                270                                                       

ttagtgggtt ccctttcctg tccccagtcg agccctcctc ccttcccctg cccctccttt     1236

ccacgccctg gaaaccatct cacttcacag ggcaggtgta gcctttctga ttcctcggtt     1296

gtttcttgca tttcttggct ttgggtatcc ttcattcaga cgggctctga tttactgaag     1356

gtgtgatgga gcttattgtc aaagccaagg gtggcgtttt gggggcgctt cttgagacga     1416

aaaagaccct gggaagagat gatggtggca tatctaaaga gtttgcagag cggactgacg     1476

ctcctcccct ttctctttaa cgccgaagga cttggtgcag ttcgtgtgaa tctcacaggg     1536

ggaatgcaac tggttcctgt gatctcttca cctttgcttc tacatagaga tgttaatgtc     1596

gagtagaaag aaatgtatct tagcatctga atgattttgc tggtaataat attatccaca     1656

gatttgcaat ggctggcatc tgctttattc ccattgctgt ctgcaggctg tgggaatttc     1716

acctgtcaaa ccaaacttcc ctctctgatg tgcactttgt tctgtttccc agattcgtca     1776

caatgcctat tgtcctgtcc ttctctttcc tttttcttcc ccattttgcc atctgtctct     1836

tatgatttat aaggggaaaa aaacttgttt tgttagaggg gcaggttaga agtcattgta     1896

taatttgtag gctttgtaat gattgaatgc aagcgtggaa atttaggctg aactctctat     1956

caaaaggaaa aatgtggagg aaaagggaaa aatcaggagg gaggattgcc tcatgtatta     2016

tttatttcga ccttttaggg gagaaggaac tcccccattc tttcaagaga ttaaaaataa     2076

atcaacagtc tgaaaaccta agcagacacg gagcattatc cggatcagcc acacacgtgt     2136

tcccttctat ttattataaa gaaatttttc atgggaaaat atgtattttt tgtatattct     2196

acagagttta ttctagtatg tatttacatc ttgaagaaca agaaagttgt tcttgtgatt     2256

aaactataaa taaactatct aattttcata aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     2316

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaa           2370


<210>  6
<211>  272
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Phe Val Lys Ser Glu Thr Leu Glu Leu Lys Glu Glu Glu Asp Val 
1               5                   10                  15      


Leu Val Leu Leu Gly Ser Ala Ser Pro Ala Leu Ala Ala Leu Thr Pro 
            20                  25                  30          


Leu Ser Ser Ser Ala Asp Glu Glu Glu Glu Glu Glu Pro Gly Ala Ser 
        35                  40                  45              


Gly Gly Ala Arg Arg Gln Arg Gly Ala Glu Ala Gly Gln Gly Ala Arg 
    50                  55                  60                  


Gly Gly Val Ala Ala Gly Ala Glu Gly Cys Arg Pro Ala Arg Leu Leu 
65                  70                  75                  80  


Gly Leu Val His Asp Cys Lys Arg Arg Pro Ser Arg Ala Arg Ala Val 
                85                  90                  95      


Ser Arg Gly Ala Lys Thr Ala Glu Thr Val Gln Arg Ile Lys Lys Thr 
            100                 105                 110         


Arg Arg Leu Lys Ala Asn Asn Arg Glu Arg Asn Arg Met His Asn Leu 
        115                 120                 125             


Asn Ala Ala Leu Asp Ala Leu Arg Glu Val Leu Pro Thr Phe Pro Glu 
    130                 135                 140                 


Asp Ala Lys Leu Thr Lys Ile Glu Thr Leu Arg Phe Ala His Asn Tyr 
145                 150                 155                 160 


Ile Trp Ala Leu Thr Glu Thr Leu Arg Leu Ala Asp His Cys Gly Gly 
                165                 170                 175     


Gly Gly Gly Gly Leu Pro Gly Ala Leu Phe Ser Glu Ala Val Leu Leu 
            180                 185                 190         


Ser Pro Gly Gly Ala Ser Ala Ala Leu Ser Ser Ser Gly Asp Ser Pro 
        195                 200                 205             


Ser Pro Ala Ser Thr Trp Ser Cys Thr Asn Ser Pro Ala Pro Ser Ser 
    210                 215                 220                 


Ser Val Ser Ser Asn Ser Thr Ser Pro Tyr Ser Cys Thr Leu Ser Pro 
225                 230                 235                 240 


Ala Ser Pro Ala Gly Ser Asp Met Asp Tyr Trp Gln Pro Pro Pro Pro 
                245                 250                 255     


Asp Lys His Arg Tyr Ala Pro His Leu Pro Ile Ala Arg Asp Cys Ile 
            260                 265                 270         


<210>  7
<211>  2490
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (572)..(1282)

<400>  7
agcactctct cacttctggc cagggaacgt ggaaggcgca ccgacaggga tccggccagg       60

gagggcgagt gaaagaagga aatcagaaag gaagggagtt aacaaaataa taaaaacagc      120

ctgagccacg gctggagaga ccgagacccg gcgcaagaga gcgcagcctt agtaggagag      180

gaacgcgaga cgcggcagag cgcgttcagc actgactttt gctgctgctt ctgctttttt      240

ttttcttaga aacaagaagg cgccagcggc agcctcacac gcgagcgcca cgcgaggctc      300

ccgaagccaa cccgcgaagg gaggagggga gggaggagga ggcggcgtgc agggaggaga      360

aaaagcattt tcactttttt tgctcccact ctaagaagtc tcccggggat tttgtatata      420

ttttttaact tccgtcaggg ctcccgcttc atatttcctt ttctttccct ctctgttcct      480

gcacccaagt tctctctgtg tccccctcgc gggccccgca cctcgcgtcc cggatcgctc      540

tgattccgcg actccttggc cgccgctgcg c atg gaa agc tct gcc aag atg         592
                                   Met Glu Ser Ser Ala Lys Met            
                                   1               5                      

gag agc ggc ggc gcc ggc cag cag ccc cag ccg cag ccc cag cag ccc        640
Glu Ser Gly Gly Ala Gly Gln Gln Pro Gln Pro Gln Pro Gln Gln Pro           
        10                  15                  20                        

ttc ctg ccg ccc gca gcc tgt ttc ttt gcc acg gcc gca gcc gcg gcg        688
Phe Leu Pro Pro Ala Ala Cys Phe Phe Ala Thr Ala Ala Ala Ala Ala           
    25                  30                  35                            

gcc gca gcc gcc gca gcg gca gcg cag agc gcg cag cag cag cag cag        736
Ala Ala Ala Ala Ala Ala Ala Ala Gln Ser Ala Gln Gln Gln Gln Gln           
40                  45                  50                  55            

cag cag cag cag cag cag cag gcg ccg cag ctg aga ccg gcg gcc gac        784
Gln Gln Gln Gln Gln Gln Gln Ala Pro Gln Leu Arg Pro Ala Ala Asp           
                60                  65                  70                

ggc cag ccc tca ggg ggc ggt cac aag tca gcg ccc aag caa gtc aag        832
Gly Gln Pro Ser Gly Gly Gly His Lys Ser Ala Pro Lys Gln Val Lys           
            75                  80                  85                    

cga cag cgc tcg tct tcg ccc gaa ctg atg cgc tgc aaa cgc cgg ctc        880
Arg Gln Arg Ser Ser Ser Pro Glu Leu Met Arg Cys Lys Arg Arg Leu           
        90                  95                  100                       

aac ttc agc ggc ttt ggc tac agc ctg ccg cag cag cag ccg gcc gcc        928
Asn Phe Ser Gly Phe Gly Tyr Ser Leu Pro Gln Gln Gln Pro Ala Ala           
    105                 110                 115                           

gtg gcg cgc cgc aac gag cgc gag cgc aac cgc gtc aag ttg gtc aac        976
Val Ala Arg Arg Asn Glu Arg Glu Arg Asn Arg Val Lys Leu Val Asn           
120                 125                 130                 135           

ctg ggc ttt gcc acc ctt cgg gag cac gtc ccc aac ggc gcg gcc aac       1024
Leu Gly Phe Ala Thr Leu Arg Glu His Val Pro Asn Gly Ala Ala Asn           
                140                 145                 150               

aag aag atg agt aag gtg gag aca ctg cgc tcg gcg gtc gag tac atc       1072
Lys Lys Met Ser Lys Val Glu Thr Leu Arg Ser Ala Val Glu Tyr Ile           
            155                 160                 165                   

cgc gcg ctg cag cag ctg ctg gac gag cat gac gcg gtg agc gcc gcc       1120
Arg Ala Leu Gln Gln Leu Leu Asp Glu His Asp Ala Val Ser Ala Ala           
        170                 175                 180                       

ttc cag gca ggc gtc ctg tcg ccc acc atc tcc ccc aac tac tcc aac       1168
Phe Gln Ala Gly Val Leu Ser Pro Thr Ile Ser Pro Asn Tyr Ser Asn           
    185                 190                 195                           

gac ttg aac tcc atg gcc ggc tcg ccg gtc tca tcc tac tcg tcg gac       1216
Asp Leu Asn Ser Met Ala Gly Ser Pro Val Ser Ser Tyr Ser Ser Asp           
200                 205                 210                 215           

gag ggc tct tac gac ccg ctc agc ccc gag gag cag gag ctt ctc gac       1264
Glu Gly Ser Tyr Asp Pro Leu Ser Pro Glu Glu Gln Glu Leu Leu Asp           
                220                 225                 230               

ttc acc aac tgg ttc tga ggggctcggc ctggtcaggc cctggtgcga              1312
Phe Thr Asn Trp Phe                                                       
            235                                                           

atggactttg gaagcagggt gatcgcacaa cctgcatctt tagtgctttc ttgtcagtgg     1372

cgttgggagg gggagaaaag gaaaagaaaa aaaaaagaag aagaagaaga aaagagaaga     1432

agaaaaaaac gaaaacagtc aaccaacccc atcgccaact aagcgaggca tgcctgagag     1492

acatggcttt cagaaaacgg gaagcgctca gaacagtatc tttgcactcc aatcattcac     1552

ggagatatga agagcaactg ggacctgagt caatgcgcaa aatgcagctt gtgtgcaaaa     1612

gcagtgggct cctggcagaa gggagcagca cacgcgttat agtaactccc atcacctcta     1672

acacgcacag ctgaaagttc ttgctcgggt cccttcacct cctcgccctt tcttaaagtg     1732

cagttcttag ccctctagaa acgagttggt gtctttcgtc tcagtagccc ccaccccaat     1792

aagctgtaga cattggttta cagtgaaact atgctattct cagccctttg aaactctgct     1852

tctcctccag ggcccgattc ccaaacccca tggcttccct cacactgtct tttctaccat     1912

tttcattata gaatgcttcc aatcttttgt gaatttttta ttataaaaaa tctatttgta     1972

tctatcctaa ccagttcggg gatatattaa gatatttttg tacataagag agaaagagag     2032

agaaaaattt atagaagttt tgtacaaatg gtttaaaatg tgtatatctt gatactttaa     2092

catgtaatgc tattacctct gcatatttta gatgtgtagt tcaccttaca actgcaattt     2152

tccctatgtg gttttgtaaa gaactctcct cataggtgag atcaagaggc caccagttgt     2212

acttcagcac caatgtgtct tactttatag aaatgttgtt aatgtattaa tgatgttatt     2272

aaatactgtt caagaagaac aaagtttatg cagctactgt ccaaactcaa agtggcagcc     2332

agttggtttt gataggttgc cttttggaga tttctattac tgcctttttt tttcttactg     2392

ttttattaca aacttacaaa aatatgtata accctgtttt atacaaacta gtttcgtaat     2452

aaaacttttt ccttttttta aaatgaaaat aaaaaaaa                             2490


<210>  8
<211>  236
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Glu Ser Ser Ala Lys Met Glu Ser Gly Gly Ala Gly Gln Gln Pro 
1               5                   10                  15      


Gln Pro Gln Pro Gln Gln Pro Phe Leu Pro Pro Ala Ala Cys Phe Phe 
            20                  25                  30          


Ala Thr Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Gln 
        35                  40                  45              


Ser Ala Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Ala Pro 
    50                  55                  60                  


Gln Leu Arg Pro Ala Ala Asp Gly Gln Pro Ser Gly Gly Gly His Lys 
65                  70                  75                  80  


Ser Ala Pro Lys Gln Val Lys Arg Gln Arg Ser Ser Ser Pro Glu Leu 
                85                  90                  95      


Met Arg Cys Lys Arg Arg Leu Asn Phe Ser Gly Phe Gly Tyr Ser Leu 
            100                 105                 110         


Pro Gln Gln Gln Pro Ala Ala Val Ala Arg Arg Asn Glu Arg Glu Arg 
        115                 120                 125             


Asn Arg Val Lys Leu Val Asn Leu Gly Phe Ala Thr Leu Arg Glu His 
    130                 135                 140                 


Val Pro Asn Gly Ala Ala Asn Lys Lys Met Ser Lys Val Glu Thr Leu 
145                 150                 155                 160 


Arg Ser Ala Val Glu Tyr Ile Arg Ala Leu Gln Gln Leu Leu Asp Glu 
                165                 170                 175     


His Asp Ala Val Ser Ala Ala Phe Gln Ala Gly Val Leu Ser Pro Thr 
            180                 185                 190         


Ile Ser Pro Asn Tyr Ser Asn Asp Leu Asn Ser Met Ala Gly Ser Pro 
        195                 200                 205             


Val Ser Ser Tyr Ser Ser Asp Glu Gly Ser Tyr Asp Pro Leu Ser Pro 
    210                 215                 220                 


Glu Glu Gln Glu Leu Leu Asp Phe Thr Asn Trp Phe 
225                 230                 235     


<210>  9
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MluI-Lmo4.fw primer

<400>  9
ggacgcgttg agagcagctc                                                   20


<210>  10
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MluI-Lmo4.rev primer

<400>  10
ggacgcgttt ctgcattact c                                                 21


<210>  11
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pCDK5C.fw primer

<400>  11
aggactaaac gcgtcgtgtc c                                                 21


<210>  12
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ctip2MAR.fw primer

<400>  12
gcttggactc agtgtacctc                                                   20


<210>  13
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ctip2MAR.rev primer

<400>  13
caagaaagca cacaccgaga                                                   20


