                         SEQUENCE LISTING

<110>  The Government of the United States of America as 
       Represented by the Secretary, Department of Health and Human 
       Services
       The Trustees of Columbia University in the City of New York
 
<120>  NEUTRALIZING ANTIBODIES TO HIV-1 GP41 AND THEIR USE

<130>  4239-94645-02

<150>  US 62/250360
<151>  2015-11-03

<160>  86    

<170>  PatentIn version 3.5

<210>  1
<211>  131
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant Antibody Sequence

<400>  1

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Phe Asp Phe Asp Asn Ala 
            20                  25                  30          


Trp Met Thr Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Thr Gly Pro Gly Glu Gly Trp Ser Val Asp Tyr Ala Ala 
    50                  55                  60                  


Pro Val Glu Gly Arg Phe Thr Ile Ser Arg Leu Asn Ser Ile Asn Phe 
65                  70                  75                  80  


Leu Tyr Leu Glu Met Asn Asn Leu Arg Met Glu Asp Ser Gly Leu Tyr 
                85                  90                  95      


Phe Cys Ala Arg Thr Gly Lys Tyr Tyr Asp Phe Trp Ser Gly Tyr Pro 
            100                 105                 110         


Pro Gly Glu Glu Tyr Phe Gln Asp Trp Gly Arg Gly Thr Leu Val Thr 
        115                 120                 125             


Val Ser Ser 
    130     


<210>  2
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant Antibody Sequence

<400>  2

Ser Tyr Glu Leu Thr Gln Glu Thr Gly Val Ser Val Ala Leu Gly Arg 
1               5                   10                  15      


Thr Val Thr Ile Thr Cys Arg Gly Asp Ser Leu Arg Ser His Tyr Ala 
            20                  25                  30          


Ser Trp Tyr Gln Lys Lys Pro Gly Gln Ala Pro Ile Leu Leu Phe Tyr 
        35                  40                  45              


Gly Lys Asn Asn Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  


Ala Ser Gly Asn Arg Ala Ser Leu Thr Ile Ser Gly Ala Gln Ala Glu 
65                  70                  75                  80  


Asp Asp Ala Glu Tyr Tyr Cys Ser Ser Arg Asp Lys Ser Gly Ser Arg 
                85                  90                  95      


Leu Ser Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  3
<211>  131
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant Antibody Sequence

<400>  3

Glu Val Arg Leu Ala Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Phe Asp Phe Asp Asn Ala 
            20                  25                  30          


Trp Met Thr Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Thr Gly Pro Gly Glu Gly Trp Ser Val Asp Tyr Ala Ala 
    50                  55                  60                  


Pro Val Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Tyr Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Glu Met Asn Asn Leu Arg Thr Glu Asp Ser Gly Leu Tyr 
                85                  90                  95      


Phe Cys Ala Arg Thr Gly Lys Tyr Tyr Asp Phe Trp Ser Gly Tyr Pro 
            100                 105                 110         


Pro Gly Glu Glu Tyr Phe Gln Asp Trp Gly Arg Gly Thr Leu Val Ile 
        115                 120                 125             


Val Ser Ser 
    130     


<210>  4
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant Antibody Sequence

<400>  4

Ser Tyr Glu Leu Thr Gln Asp Thr Gly Val Ser Val Ala Leu Gly Arg 
1               5                   10                  15      


Thr Val Thr Ile Thr Cys Arg Gly Asp Ser Leu Arg Ser His Tyr Ala 
            20                  25                  30          


Ser Trp Tyr Gln Lys Lys Pro Gly Gln Ala Pro Val Leu Leu Phe Tyr 
        35                  40                  45              


Gly Lys Asn Asn Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  


Ala Ser Gly Asn Arg Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Arg Asp Lys Ser Gly Ser Arg 
                85                  90                  95      


Leu Ser Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  5
<211>  131
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant Antibody Sequence

<400>  5

Glu Val Arg Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Phe Asp Phe Asp Asn Ala 
            20                  25                  30          


Trp Met Thr Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Thr Gly Pro Gly Glu Gly Trp Ser Val Asp Tyr Ala Glu 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Thr Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Glu Met Asn Asn Val Arg Thr Glu Asp Thr Gly Tyr Tyr 
                85                  90                  95      


Phe Cys Ala Arg Thr Gly Lys Tyr Tyr Asp Phe Trp Ser Gly Tyr Pro 
            100                 105                 110         


Pro Gly Glu Glu Tyr Phe Gln Asp Trp Gly Gln Gly Thr Leu Val Ile 
        115                 120                 125             


Val Ser Ser 
    130     


<210>  6
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant Antibody Sequence

<400>  6

Ala Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Lys Gln 
1               5                   10                  15      


Thr Val Thr Ile Thr Cys Arg Gly Asp Ser Leu Arg Ser His Tyr Ala 
            20                  25                  30          


Ser Trp Tyr Gln Lys Lys Pro Gly Gln Ala Pro Val Leu Leu Phe Tyr 
        35                  40                  45              


Gly Lys Asn Asn Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  


Ala Ser Gly Asn Arg Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Arg Asp Lys Ser Gly Ser Arg 
                85                  90                  95      


Leu Ser Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  7
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant Antibody Sequence

<400>  7

Gly Phe Asp Phe Asp Asn Ala Trp 
1               5               


<210>  8
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant Antibody Sequence

<400>  8

Ile Thr Gly Pro Gly Glu Gly Trp Ser Val 
1               5                   10  


<210>  9
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant Antibody Sequence

<400>  9

Ala Arg Thr Gly Lys Tyr Tyr Asp Phe Trp Ser Gly Tyr Pro Pro Gly 
1               5                   10                  15      


Glu Glu Tyr Phe Gln Asp 
            20          


<210>  10
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant Antibody Sequence

<400>  10

Ser Leu Arg Ser His Tyr 
1               5       


<210>  11
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant Antibody Sequence

<400>  11

Gly Lys Asn 
1           


<210>  12
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant Antibody Sequence

<400>  12

Ser Ser Arg Asp Lys Ser Gly Ser Arg Leu Ser Val 
1               5                   10          


<210>  13
<211>  131
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant Antibody Sequence

<400>  13

Glu Val Arg Leu Ala Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Phe Asp Phe Asp Asn Ala 
            20                  25                  30          


Trp Met Thr Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Thr Gly Pro Gly Glu Gly Trp Ser Val Asp Tyr Ala Ala 
    50                  55                  60                  


Pro Val Glu Gly Arg Phe Thr Ile Ser Arg Leu Asn Tyr Ile Asn Phe 
65                  70                  75                  80  


Leu Tyr Leu Glu Met Asn Asn Leu Arg Met Glu Asp Ser Gly Leu Tyr 
                85                  90                  95      


Phe Cys Ala Arg Thr Gly Lys Tyr Tyr Asp Phe Trp Ser Gly Tyr Pro 
            100                 105                 110         


Pro Gly Glu Glu Tyr Phe Gln Asp Trp Gly Arg Gly Thr Leu Val Ile 
        115                 120                 125             


Val Ser Ser 
    130     


<210>  14
<211>  131
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant Antibody Sequence

<400>  14

Glu Val Arg Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Phe Asn Phe Asp Asp Ala 
            20                  25                  30          


Trp Met Thr Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Ser Gly Pro Gly Glu Gly Trp Ser Val Asp Tyr Ala Glu 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Leu Asn Ser Ile Asn Phe 
65                  70                  75                  80  


Leu Tyr Leu Glu Met Asn Asn Val Arg Thr Glu Asp Thr Gly Tyr Tyr 
                85                  90                  95      


Phe Cys Ala Arg Thr Gly Lys His Tyr Asp Phe Trp Ser Gly Tyr Pro 
            100                 105                 110         


Pro Gly Glu Glu Tyr Phe Gln Asp Trp Gly Gln Gly Thr Leu Val Ile 
        115                 120                 125             


Val Ser Ser 
    130     


<210>  15
<211>  131
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant Antibody Sequence

<400>  15

Glu Val Arg Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Phe Asn Phe Asp Asp Ala 
            20                  25                  30          


Trp Met Thr Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Ser Gly Pro Gly Glu Gly Trp Ser Val Asp Tyr Ala Glu 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Thr Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Glu Met Asn Asn Val Arg Thr Glu Asp Thr Gly Tyr Tyr 
                85                  90                  95      


Phe Cys Ala Arg Thr Gly Lys His Tyr Asp Phe Trp Ser Gly Tyr Pro 
            100                 105                 110         


Pro Gly Glu Glu Tyr Phe Gln Asp Trp Gly Gln Gly Thr Leu Val Ile 
        115                 120                 125             


Val Ser Ser 
    130     


<210>  16
<211>  131
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant Antibody Sequence

<400>  16

Glu Val Arg Leu Val Glu Ser Gly Gly Arg Leu Val Arg Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Phe Asn Phe Asp Asn Ala 
            20                  25                  30          


Trp Met Thr Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Thr Gly Pro Gly Glu Gly Trp Ser Val Asp Tyr Ala Ala 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Met Asn Ser Ile Asn Phe 
65                  70                  75                  80  


Phe Tyr Leu Glu Met Asn Asn Leu Lys Ile Glu Asp Thr Gly Leu Tyr 
                85                  90                  95      


Phe Cys Ala Arg Thr Gly Lys His Tyr Ala Phe Trp Gly Gly Tyr Pro 
            100                 105                 110         


Pro Gly Glu Glu Tyr Leu Glu Asp Trp Gly Gln Gly Thr Leu Val Ile 
        115                 120                 125             


Val Ser Ser 
    130     


<210>  17
<211>  131
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant Antibody Sequence

<400>  17

Glu Val Arg Leu Val Glu Ser Gly Gly Arg Leu Val Arg Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Phe Asn Phe Asp Asn Ala 
            20                  25                  30          


Trp Met Thr Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Thr Gly Pro Gly Glu Gly Trp Ser Val Asp Tyr Ala Ala 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Tyr Lys Asn Thr 
65                  70                  75                  80  


Phe Tyr Leu Glu Met Asn Asn Leu Lys Thr Glu Asp Thr Gly Leu Tyr 
                85                  90                  95      


Phe Cys Ala Arg Thr Gly Lys His Tyr Ala Phe Trp Gly Gly Tyr Pro 
            100                 105                 110         


Pro Gly Glu Glu Tyr Leu Glu Asp Trp Gly Gln Gly Thr Leu Val Ile 
        115                 120                 125             


Val Ser Ser 
    130     


<210>  18
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant Antibody Sequence

<400>  18

Ala Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Lys Gln 
1               5                   10                  15      


Thr Val Thr Ile Thr Cys Arg Gly Asp Ser Leu Arg Ser His Tyr Val 
            20                  25                  30          


Ser Trp Tyr Gln Lys Lys Pro Gly Gln Ala Pro Val Leu Val Phe Tyr 
        35                  40                  45              


Gly Lys Asn Asn Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  


Ser Ser Gly Asn Thr Ala Ser Leu Thr Ile Ala Gly Ala Gln Ala Glu 
65                  70                  75                  80  


Asp Asp Ala Asp Tyr Tyr Cys Ser Ser Arg Asp Lys Ser Gly Ser Arg 
                85                  90                  95      


Leu Ser Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  19
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant Antibody Sequence

<400>  19

Ala Ser Glu Leu Thr Gln Asp Pro Thr Val Ser Val Ala Leu Gly Gln 
1               5                   10                  15      


Thr Val Thr Ile Thr Cys Arg Gly Asp Ser Leu Arg Asn Tyr Tyr Thr 
            20                  25                  30          


Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Leu Ile Tyr 
        35                  40                  45              


Pro Lys His Asn Arg Pro Pro Gly Ile Ser Asp Arg Phe Ser Ala Ser 
    50                  55                  60                  


Ser Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Thr Glu 
65                  70                  75                  80  


Asp Glu Gly Asp Tyr Tyr Cys Ser Ser Arg Asp Lys Ser Gly Ser Arg 
                85                  90                  95      


Leu Val Thr Phe Gly Arg Gly Thr Lys Leu Thr Val Val 
            100                 105                 


<210>  20
<211>  1443
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant Antibody Sequence

<400>  20
atgggatggt catgtatcat cctttttcta gtagcaactg caaccggtgt acattctgaa       60

gtgcggctgg ctgagagcgg cggggggctg gtcaaacctg gcgggtcact gcggctgtcc      120

tgttctgcct ccggcttcga ttttgataac gcatggatga catgggtgcg acagccacct      180

ggaaaggggc tggagtgggt cggcagaatc actggacctg gcgaagggtg gtctgtggac      240

tacgcagctc cagtcgaggg acgattcacc attagtagag ataactacaa gaatacactg      300

tatctggaga tgaacaatct gaggactgaa gacagcggcc tgtatttctg cgcccgcacc      360

gggaaatact atgatttttg gtctgggtac ccacccggag aggaatattt tcaggactgg      420

ggacggggca ccctggtgat cgtcagctcc gcgtcgacca agggcccatc ggtcttcccc      480

ctggcaccct cctccaagag cacctctggg ggcacagcgg ccctgggctg cctggtcaag      540

gactacttcc ccgaaccggt gacggtgtcg tggaactcag gcgccctgac cagcggcgtg      600

cacaccttcc cggctgtcct acagtcctca ggactctact ccctcagcag cgtggtgacc      660

gtgccctcca gcagcttggg cacccagacc tacatctgca acgtgaatca caagcccagc      720

aacaccaagg tggacaagaa agttgagccc aaatcttgtg acaaaactca cacatgccca      780

ccgtgcccag cacctgaact cctgggggga ccgtcagtct tcctcttccc cccaaaaccc      840

aaggacaccc tcatgatctc ccggacccct gaggtcacat gcgtggtggt ggacgtgagc      900

cacgaagacc ctgaggtcaa gttcaactgg tacgtggacg gcgtggaggt gcataatgcc      960

aagacaaagc cgcgggagga gcagtacaac agcacgtacc gtgtggtcag cgtcctcacc     1020

gtcctgcacc aggactggct gaatggcaag gagtacaagt gcaaggtctc caacaaagcc     1080

ctcccagccc ccatcgagaa aaccatctcc aaagccaaag ggcagccccg agaaccacag     1140

gtgtacaccc tgcccccatc ccgggatgag ctgaccaaga accaggtcag cctgacctgc     1200

ctggtcaaag gcttctatcc cagcgacatc gccgtggagt gggagagcaa tgggcagccg     1260

gagaacaact acaagaccac gcctcccgtg ctggactccg acggctcctt cttcctctac     1320

agcaagctca ccgtggacaa gagcaggtgg cagcagggga acgtcttctc atgctccgtg     1380

atgcatgagg ctctgcacaa ccactacacg cagaagagcc tctccctgtc tccgggtaaa     1440

tga                                                                   1443


<210>  21
<211>  1440
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant Antibody Sequence

<400>  21
atgggatggt catgtatcat cctttttcta gtagcaactg caaccggtgt acattctgag       60

gttagactgg tggagtcagg aggggggctt gtgaagcccg gtgggtctct ccgcctgagc      120

tgttctgcct ccggctttga tttcgataac gcctggatga cctgggtcag gcagcctcca      180

ggtaagggac tggagtgggt gggaagaatc acaggtccag gcgagggctg gtccgtggac      240

tacgcggaat ctgttaaagg gcggtttaca atctcaaggg acaataccaa gaataccttg      300

tatttggaga tgaacaacgt gagaactgaa gacaccggat attacttctg tgccagaaca      360

ggcaaatact acgacttctg gtccggctat ccccctggcg aggaatattt tcaagactgg      420

ggtcagggaa cccttgttat cgtgtcctcc gcgtcgacca agggcccatc ggtcttcccc      480

ctggcaccct cctccaagag cacctctggg ggcacagcgg ccctgggctg cctggtcaag      540

gactacttcc ccgaaccggt gacggtgtcg tggaactcag gcgccctgac cagcggcgtg      600

cacaccttcc cggctgtcct acagtcctca ggactctact ccctcagcag cgtggtgacc      660

gtgccctcca gcagcttggg cacccagacc tacatctgca acgtgaatca caagcccagc      720

aacaccaagg tggacaagaa agttgagccc aaatcttgtg acaaaactca cacatgccca      780

ccgtgcccag cacctgaact cctgggggga ccgtcagtct tcctcttccc cccaaaaccc      840

aaggacaccc tcatgatctc ccggacccct gaggtcacat gcgtggtggt ggacgtgagc      900

cacgaagacc ctgaggtcaa gttcaactgg tacgtggacg gcgtggaggt gcataatgcc      960

aagacaaagc cgcgggagga gcagtacaac agcacgtacc gtgtggtcag cgtcctcacc     1020

gtcctgcacc aggactggct gaatggcaag gagtacaagt gcaaggtctc caacaaagcc     1080

ctcccagccc ccatcgagaa aaccatctcc aaagccaaag ggcagccccg agaaccacag     1140

gtgtacaccc tgcccccatc ccgggatgag ctgaccaaga accaggtcag cctgacctgc     1200

ctggtcaaag gcttctatcc cagcgacatc gccgtggagt gggagagcaa tgggcagccg     1260

gagaacaact acaagaccac gcctcccgtg ctggactccg acggctcctt cttcctctac     1320

agcaagctca ccgtggacaa gagcaggtgg cagcagggga acgtcttctc atgctccgtg     1380

atgcatgagg ctctgcacaa ccactacacg cagaagagcc tctccctgtc tccgggtaaa     1440


<210>  22
<211>  461
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant Antibody Sequence

<400>  22

Glu Val Arg Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Phe Asp Phe Asp Asn Ala 
            20                  25                  30          


Trp Met Thr Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Thr Gly Pro Gly Glu Gly Trp Ser Val Asp Tyr Ala Glu 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Thr Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Glu Met Asn Asn Val Arg Thr Glu Asp Thr Gly Tyr Tyr 
                85                  90                  95      


Phe Cys Ala Arg Thr Gly Lys Tyr Tyr Asp Phe Trp Ser Gly Tyr Pro 
            100                 105                 110         


Pro Gly Glu Glu Tyr Phe Gln Asp Trp Gly Gln Gly Thr Leu Val Ile 
        115                 120                 125             


Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
    130                 135                 140                 


Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val 
145                 150                 155                 160 


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
                165                 170                 175     


Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
            180                 185                 190         


Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 
        195                 200                 205             


Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys 
    210                 215                 220                 


Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys 
225                 230                 235                 240 


Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 
                245                 250                 255     


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
            260                 265                 270         


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
        275                 280                 285             


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
    290                 295                 300                 


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
305                 310                 315                 320 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
                325                 330                 335     


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
            340                 345                 350         


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
        355                 360                 365             


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
    370                 375                 380                 


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
385                 390                 395                 400 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
                405                 410                 415     


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
            420                 425                 430         


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
        435                 440                 445             


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455                 460     


<210>  23
<211>  461
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant Antibody Sequence

<400>  23

Glu Val Arg Leu Ala Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Phe Asp Phe Asp Asn Ala 
            20                  25                  30          


Trp Met Thr Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Thr Gly Pro Gly Glu Gly Trp Ser Val Asp Tyr Ala Ala 
    50                  55                  60                  


Pro Val Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Tyr Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Glu Met Asn Asn Leu Arg Thr Glu Asp Ser Gly Leu Tyr 
                85                  90                  95      


Phe Cys Ala Arg Thr Gly Lys Tyr Tyr Asp Phe Trp Ser Gly Tyr Pro 
            100                 105                 110         


Pro Gly Glu Glu Tyr Phe Gln Asp Trp Gly Arg Gly Thr Leu Val Ile 
        115                 120                 125             


Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
    130                 135                 140                 


Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val 
145                 150                 155                 160 


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
                165                 170                 175     


Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
            180                 185                 190         


Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 
        195                 200                 205             


Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys 
    210                 215                 220                 


Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys 
225                 230                 235                 240 


Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 
                245                 250                 255     


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
            260                 265                 270         


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
        275                 280                 285             


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
    290                 295                 300                 


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
305                 310                 315                 320 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
                325                 330                 335     


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
            340                 345                 350         


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
        355                 360                 365             


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
    370                 375                 380                 


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
385                 390                 395                 400 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
                405                 410                 415     


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
            420                 425                 430         


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
        435                 440                 445             


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455                 460     


<210>  24
<211>  648
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant Antibody Sequence

<400>  24

Thr Cys Ala Thr Ala Cys Gly Ala Ala Cys Thr Gly Ala Cys Thr Cys 
1               5                   10                  15      


Ala Gly Gly Ala Cys Ala Cys Thr Gly Gly Cys Gly Thr Cys Thr Cys 
            20                  25                  30          


Thr Gly Thr Gly Gly Cys Ala Cys Thr Gly Gly Gly Gly Ala Gly Gly 
        35                  40                  45              


Ala Cys Thr Gly Thr Gly Ala Cys Thr Ala Thr Thr Ala Cys Thr Thr 
    50                  55                  60                  


Gly Cys Cys Gly Ala Gly Gly Cys Gly Ala Cys Thr Cys Ala Cys Thr 
65                  70                  75                  80  


Gly Cys Gly Gly Ala Gly Cys Cys Ala Cys Thr Ala Cys Gly Cys Thr 
                85                  90                  95      


Thr Cys Cys Thr Gly Gly Thr Ala Thr Cys Ala Gly Ala Ala Gly Ala 
            100                 105                 110         


Ala Ala Cys Cys Cys Gly Gly Cys Cys Ala Gly Gly Cys Ala Cys Cys 
        115                 120                 125             


Thr Gly Thr Gly Cys Thr Gly Cys Thr Gly Thr Thr Cys Thr Ala Cys 
    130                 135                 140                 


Gly Gly Ala Ala Ala Gly Ala Ala Cys Ala Ala Thr Ala Gly Gly Cys 
145                 150                 155                 160 


Cys Ala Thr Cys Thr Gly Gly Cys Ala Thr Cys Cys Cys Cys Gly Ala 
                165                 170                 175     


Cys Cys Gly Cys Thr Thr Thr Thr Cys Thr Gly Gly Cys Ala Gly Thr 
            180                 185                 190         


Gly Cys Ala Thr Cys Ala Gly Gly Gly Ala Ala Cys Cys Gly Ala Gly 
        195                 200                 205             


Cys Cys Ala Gly Thr Cys Thr Gly Ala Cys Cys Ala Thr Thr Ala Cys 
    210                 215                 220                 


Cys Gly Gly Cys Gly Cys Cys Cys Ala Gly Gly Cys Thr Gly Ala Gly 
225                 230                 235                 240 


Gly Ala Cys Gly Ala Ala Gly Cys Cys Gly Ala Thr Thr Ala Cys Thr 
                245                 250                 255     


Ala Thr Thr Gly Cys Ala Gly Cys Thr Cys Cys Cys Gly Gly Gly Ala 
            260                 265                 270         


Thr Ala Ala Gly Ala Gly Cys Gly Gly Cys Thr Cys Cys Ala Gly Ala 
        275                 280                 285             


Cys Thr Gly Ala Gly Cys Gly Thr Gly Thr Thr Cys Gly Gly Ala Gly 
    290                 295                 300                 


Gly Ala Gly Gly Ala Ala Cys Thr Ala Ala Ala Cys Thr Gly Ala Cys 
305                 310                 315                 320 


Cys Gly Thr Cys Cys Thr Cys Ala Gly Thr Cys Ala Gly Cys Cys Cys 
                325                 330                 335     


Ala Ala Gly Gly Cys Thr Gly Cys Cys Cys Cys Cys Thr Cys Gly Gly 
            340                 345                 350         


Thr Cys Ala Cys Thr Cys Thr Gly Thr Thr Cys Cys Cys Gly Cys Cys 
        355                 360                 365             


Cys Thr Cys Gly Ala Gly Thr Gly Ala Gly Gly Ala Gly Cys Thr Thr 
    370                 375                 380                 


Cys Ala Ala Gly Cys Cys Ala Ala Cys Ala Ala Gly Gly Cys Cys Ala 
385                 390                 395                 400 


Cys Ala Cys Thr Gly Gly Thr Gly Thr Gly Thr Cys Thr Cys Ala Thr 
                405                 410                 415     


Ala Ala Gly Thr Gly Ala Cys Thr Thr Cys Thr Ala Cys Cys Cys Gly 
            420                 425                 430         


Gly Gly Ala Gly Cys Cys Gly Thr Gly Ala Cys Ala Gly Thr Gly Gly 
        435                 440                 445             


Cys Cys Thr Gly Gly Ala Ala Gly Gly Cys Ala Gly Ala Thr Ala Gly 
    450                 455                 460                 


Cys Ala Gly Cys Cys Cys Cys Gly Thr Cys Ala Ala Gly Gly Cys Gly 
465                 470                 475                 480 


Gly Gly Ala Gly Thr Gly Gly Ala Gly Ala Cys Cys Ala Cys Cys Ala 
                485                 490                 495     


Cys Ala Cys Cys Cys Thr Cys Cys Ala Ala Ala Cys Ala Ala Ala Gly 
            500                 505                 510         


Cys Ala Ala Cys Ala Ala Cys Ala Ala Gly Thr Ala Cys Gly Cys Gly 
        515                 520                 525             


Gly Cys Cys Ala Gly Cys Ala Gly Cys Thr Ala Cys Cys Thr Gly Ala 
    530                 535                 540                 


Gly Cys Cys Thr Gly Ala Cys Gly Cys Cys Thr Gly Ala Gly Cys Ala 
545                 550                 555                 560 


Gly Thr Gly Gly Ala Ala Gly Thr Cys Cys Cys Ala Cys Ala Gly Ala 
                565                 570                 575     


Ala Gly Cys Thr Ala Cys Ala Gly Cys Thr Gly Cys Cys Ala Gly Gly 
            580                 585                 590         


Thr Cys Ala Cys Gly Cys Ala Thr Gly Ala Ala Gly Gly Gly Ala Gly 
        595                 600                 605             


Cys Ala Cys Cys Gly Thr Gly Gly Ala Gly Ala Ala Gly Ala Cys Ala 
    610                 615                 620                 


Gly Thr Gly Gly Cys Cys Cys Cys Thr Ala Cys Ala Gly Ala Ala Thr 
625                 630                 635                 640 


Gly Thr Thr Cys Ala Thr Ala Gly 
                645             


<210>  25
<211>  678
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant Antibody Sequence

<400>  25

Ala Cys Cys Ala Cys Cys Ala Thr Gly Gly Gly Ala Thr Gly Gly Thr 
1               5                   10                  15      


Cys Ala Thr Gly Thr Ala Thr Cys Ala Thr Cys Cys Thr Thr Thr Thr 
            20                  25                  30          


Thr Cys Thr Ala Gly Thr Ala Gly Cys Ala Ala Cys Thr Gly Cys Ala 
        35                  40                  45              


Ala Cys Cys Gly Gly Thr Thr Cys Thr Gly Thr Gly Ala Cys Cys Gly 
    50                  55                  60                  


Cys Ala Thr Cys Cys Gly Ala Ala Cys Thr Gly Ala Cys Thr Cys Ala 
65                  70                  75                  80  


Gly Gly Ala Cys Cys Cys Thr Gly Cys Cys Gly Thr Cys Thr Cys Thr 
                85                  90                  95      


Gly Thr Gly Gly Cys Ala Cys Thr Gly Ala Ala Gly Cys Ala Gly Ala 
            100                 105                 110         


Cys Thr Gly Thr Gly Ala Cys Thr Ala Thr Thr Ala Cys Thr Thr Gly 
        115                 120                 125             


Cys Cys Gly Ala Gly Gly Cys Gly Ala Cys Thr Cys Ala Cys Thr Gly 
    130                 135                 140                 


Cys Gly Gly Ala Gly Cys Cys Ala Cys Thr Ala Cys Gly Cys Thr Thr 
145                 150                 155                 160 


Cys Cys Thr Gly Gly Thr Ala Thr Cys Ala Gly Ala Ala Gly Ala Ala 
                165                 170                 175     


Ala Cys Cys Cys Gly Gly Cys Cys Ala Gly Gly Cys Ala Cys Cys Thr 
            180                 185                 190         


Gly Thr Gly Cys Thr Gly Cys Thr Gly Thr Thr Cys Thr Ala Cys Gly 
        195                 200                 205             


Gly Ala Ala Ala Gly Ala Ala Cys Ala Ala Thr Ala Gly Gly Cys Cys 
    210                 215                 220                 


Ala Thr Cys Thr Gly Gly Cys Ala Thr Cys Cys Cys Cys Gly Ala Cys 
225                 230                 235                 240 


Cys Gly Cys Thr Thr Thr Thr Cys Thr Gly Gly Cys Ala Gly Thr Gly 
                245                 250                 255     


Cys Ala Thr Cys Ala Gly Gly Gly Ala Ala Cys Cys Gly Ala Gly Cys 
            260                 265                 270         


Cys Ala Gly Thr Cys Thr Gly Ala Cys Cys Ala Thr Thr Ala Cys Cys 
        275                 280                 285             


Gly Gly Cys Gly Cys Cys Cys Ala Gly Gly Cys Thr Gly Ala Gly Gly 
    290                 295                 300                 


Ala Cys Gly Ala Ala Gly Cys Cys Gly Ala Thr Thr Ala Cys Thr Ala 
305                 310                 315                 320 


Thr Thr Gly Cys Ala Gly Cys Thr Cys Cys Cys Gly Gly Gly Ala Thr 
                325                 330                 335     


Ala Ala Gly Ala Gly Cys Gly Gly Cys Thr Cys Cys Ala Gly Ala Cys 
            340                 345                 350         


Thr Gly Ala Gly Cys Gly Thr Gly Thr Thr Cys Gly Gly Ala Gly Gly 
        355                 360                 365             


Ala Gly Gly Ala Ala Cys Thr Ala Ala Ala Cys Thr Gly Ala Cys Cys 
    370                 375                 380                 


Gly Thr Cys Cys Thr Cys Ala Gly Thr Cys Ala Gly Cys Cys Cys Ala 
385                 390                 395                 400 


Ala Gly Gly Cys Thr Gly Cys Cys Cys Cys Cys Thr Cys Gly Gly Thr 
                405                 410                 415     


Cys Ala Cys Thr Cys Thr Gly Thr Thr Cys Cys Cys Gly Cys Cys Cys 
            420                 425                 430         


Thr Cys Gly Ala Gly Thr Gly Ala Gly Gly Ala Gly Cys Thr Thr Cys 
        435                 440                 445             


Ala Ala Gly Cys Cys Ala Ala Cys Ala Ala Gly Gly Cys Cys Ala Cys 
    450                 455                 460                 


Ala Cys Thr Gly Gly Thr Gly Thr Gly Thr Cys Thr Cys Ala Thr Ala 
465                 470                 475                 480 


Ala Gly Thr Gly Ala Cys Thr Thr Cys Thr Ala Cys Cys Cys Gly Gly 
                485                 490                 495     


Gly Ala Gly Cys Cys Gly Thr Gly Ala Cys Ala Gly Thr Gly Gly Cys 
            500                 505                 510         


Cys Thr Gly Gly Ala Ala Gly Gly Cys Ala Gly Ala Thr Ala Gly Cys 
        515                 520                 525             


Ala Gly Cys Cys Cys Cys Gly Thr Cys Ala Ala Gly Gly Cys Gly Gly 
    530                 535                 540                 


Gly Ala Gly Thr Gly Gly Ala Gly Ala Cys Cys Ala Cys Cys Ala Cys 
545                 550                 555                 560 


Ala Cys Cys Cys Thr Cys Cys Ala Ala Ala Cys Ala Ala Ala Gly Cys 
                565                 570                 575     


Ala Ala Cys Ala Ala Cys Ala Ala Gly Thr Ala Cys Gly Cys Gly Gly 
            580                 585                 590         


Cys Cys Ala Gly Cys Ala Gly Cys Thr Ala Cys Cys Thr Gly Ala Gly 
        595                 600                 605             


Cys Cys Thr Gly Ala Cys Gly Cys Cys Thr Gly Ala Asn Cys Ala Gly 
    610                 615                 620                 


Thr Gly Gly Ala Ala Asn Gly Thr Cys Cys Cys Ala Cys Ala Gly Ala 
625                 630                 635                 640 


Ala Gly Cys Thr Ala Cys Ala Gly Cys Thr Gly Cys Cys Ala Gly Gly 
                645                 650                 655     


Thr Cys Ala Cys Gly Cys Ala Thr Gly Ala Ala Gly Gly Gly Ala Gly 
            660                 665                 670         


Cys Ala Cys Cys Gly Thr 
        675             


<210>  26
<211>  856
<212>  PRT
<213>  Human immunodeficiency virus type 1

<400>  26

Met Arg Val Lys Glu Lys Tyr Gln His Leu Trp Arg Trp Gly Trp Arg 
1               5                   10                  15      


Trp Gly Thr Met Leu Leu Gly Met Leu Met Ile Cys Ser Ala Thr Glu 
            20                  25                  30          


Lys Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Lys Glu Ala 
        35                  40                  45              


Thr Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala Tyr Asp Thr Glu 
    50                  55                  60                  


Val His Asn Val Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Asn 
65                  70                  75                  80  


Pro Gln Glu Val Val Leu Val Asn Val Thr Glu Asn Phe Asn Met Trp 
                85                  90                  95      


Lys Asn Asp Met Val Glu Gln Met His Glu Asp Ile Ile Ser Leu Trp 
            100                 105                 110         


Asp Gln Ser Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val Ser 
        115                 120                 125             


Leu Lys Cys Thr Asp Leu Lys Asn Asp Thr Asn Thr Asn Ser Ser Ser 
    130                 135                 140                 


Gly Arg Met Ile Met Glu Lys Gly Glu Ile Lys Asn Cys Ser Phe Asn 
145                 150                 155                 160 


Ile Ser Thr Ser Ile Arg Gly Lys Val Gln Lys Glu Tyr Ala Phe Phe 
                165                 170                 175     


Tyr Lys Leu Asp Ile Ile Pro Ile Asp Asn Asp Thr Thr Ser Tyr Lys 
            180                 185                 190         


Leu Thr Ser Cys Asn Thr Ser Val Ile Thr Gln Ala Cys Pro Lys Val 
        195                 200                 205             


Ser Phe Glu Pro Ile Pro Ile His Tyr Cys Ala Pro Ala Gly Phe Ala 
    210                 215                 220                 


Ile Leu Lys Cys Asn Asn Lys Thr Phe Asn Gly Thr Gly Pro Cys Thr 
225                 230                 235                 240 


Asn Val Ser Thr Val Gln Cys Thr His Gly Ile Arg Pro Val Val Ser 
                245                 250                 255     


Thr Gln Leu Leu Leu Asn Gly Ser Leu Ala Glu Glu Glu Val Val Ile 
            260                 265                 270         


Arg Ser Val Asn Phe Thr Asp Asn Ala Lys Thr Ile Ile Val Gln Leu 
        275                 280                 285             


Asn Thr Ser Val Glu Ile Asn Cys Thr Arg Pro Asn Asn Asn Thr Arg 
    290                 295                 300                 


Lys Arg Ile Arg Ile Gln Arg Gly Pro Gly Arg Ala Phe Val Thr Ile 
305                 310                 315                 320 


Gly Lys Ile Gly Asn Met Arg Gln Ala His Cys Asn Ile Ser Arg Ala 
                325                 330                 335     


Lys Trp Asn Asn Thr Leu Lys Gln Ile Ala Ser Lys Leu Arg Glu Gln 
            340                 345                 350         


Phe Gly Asn Asn Lys Thr Ile Ile Phe Lys Gln Ser Ser Gly Gly Asp 
        355                 360                 365             


Pro Glu Ile Val Thr His Ser Phe Asn Cys Gly Gly Glu Phe Phe Tyr 
    370                 375                 380                 


Cys Asn Ser Thr Gln Leu Phe Asn Ser Thr Trp Phe Asn Ser Thr Trp 
385                 390                 395                 400 


Ser Thr Glu Gly Ser Asn Asn Thr Glu Gly Ser Asp Thr Ile Thr Leu 
                405                 410                 415     


Pro Cys Arg Ile Lys Gln Ile Ile Asn Met Trp Gln Lys Val Gly Lys 
            420                 425                 430         


Ala Met Tyr Ala Pro Pro Ile Ser Gly Gln Ile Arg Cys Ser Ser Asn 
        435                 440                 445             


Ile Thr Gly Leu Leu Leu Thr Arg Asp Gly Gly Asn Ser Asn Asn Glu 
    450                 455                 460                 


Ser Glu Ile Phe Arg Pro Gly Gly Gly Asp Met Arg Asp Asn Trp Arg 
465                 470                 475                 480 


Ser Glu Leu Tyr Lys Tyr Lys Val Val Lys Ile Glu Pro Leu Gly Val 
                485                 490                 495     


Ala Pro Thr Lys Ala Lys Arg Arg Val Val Gln Arg Glu Lys Arg Ala 
            500                 505                 510         


Val Gly Ile Gly Ala Leu Phe Leu Gly Phe Leu Gly Ala Ala Gly Ser 
        515                 520                 525             


Thr Met Gly Ala Ala Ser Met Thr Leu Thr Val Gln Ala Arg Gln Leu 
    530                 535                 540                 


Leu Ser Gly Ile Val Gln Gln Gln Asn Asn Leu Leu Arg Ala Ile Glu 
545                 550                 555                 560 


Ala Gln Gln His Leu Leu Gln Leu Thr Val Trp Gly Ile Lys Gln Leu 
                565                 570                 575     


Gln Ala Arg Ile Leu Ala Val Glu Arg Tyr Leu Lys Asp Gln Gln Leu 
            580                 585                 590         


Leu Gly Ile Trp Gly Cys Ser Gly Lys Leu Ile Cys Thr Thr Ala Val 
        595                 600                 605             


Pro Trp Asn Ala Ser Trp Ser Asn Lys Ser Leu Glu Gln Ile Trp Asn 
    610                 615                 620                 


His Thr Thr Trp Met Glu Trp Asp Arg Glu Ile Asn Asn Tyr Thr Ser 
625                 630                 635                 640 


Leu Ile His Ser Leu Ile Glu Glu Ser Gln Asn Gln Gln Glu Lys Asn 
                645                 650                 655     


Glu Gln Glu Leu Leu Glu Leu Asp Lys Trp Ala Ser Leu Trp Asn Trp 
            660                 665                 670         


Phe Asn Ile Thr Asn Trp Leu Trp Tyr Ile Lys Leu Phe Ile Met Ile 
        675                 680                 685             


Val Gly Gly Leu Val Gly Leu Arg Ile Val Phe Ala Val Leu Ser Ile 
    690                 695                 700                 


Val Asn Arg Val Arg Gln Gly Tyr Ser Pro Leu Ser Phe Gln Thr His 
705                 710                 715                 720 


Leu Pro Thr Pro Arg Gly Pro Asp Arg Pro Glu Gly Ile Glu Glu Glu 
                725                 730                 735     


Gly Gly Glu Arg Asp Arg Asp Arg Ser Ile Arg Leu Val Asn Gly Ser 
            740                 745                 750         


Leu Ala Leu Ile Trp Asp Asp Leu Arg Ser Leu Cys Leu Phe Ser Tyr 
        755                 760                 765             


His Arg Leu Arg Asp Leu Leu Leu Ile Val Thr Arg Ile Val Glu Leu 
    770                 775                 780                 


Leu Gly Arg Arg Gly Trp Glu Ala Leu Lys Tyr Trp Trp Asn Leu Leu 
785                 790                 795                 800 


Gln Tyr Trp Ser Gln Glu Leu Lys Asn Ser Ala Val Ser Leu Leu Asn 
                805                 810                 815     


Ala Thr Ala Ile Ala Val Ala Glu Gly Thr Asp Arg Val Ile Glu Val 
            820                 825                 830         


Val Gln Gly Ala Cys Arg Ala Ile Arg His Ile Pro Arg Arg Ile Arg 
        835                 840                 845             


Gln Gly Leu Glu Arg Ile Leu Leu 
    850                 855     


<210>  27
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant Antibody Sequence

<400>  27

Gln Val Gln Leu Val Gln Ser Gly Gly Gln Met Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Met Arg Ile Ser Cys Arg Ala Ser Gly Tyr Glu Phe Ile Asp Cys 
            20                  25                  30          


Thr Leu Asn Trp Ile Arg Leu Ala Pro Gly Lys Arg Pro Glu Trp Met 
        35                  40                  45              


Gly Trp Leu Lys Pro Arg Gly Gly Ala Val Asn Tyr Ala Arg Pro Leu 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Val Tyr Ser Asp Thr Ala Phe 
65                  70                  75                  80  


Leu Glu Leu Arg Ser Leu Thr Val Asp Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Thr Arg Gly Lys Asn Cys Asp Tyr Asn Trp Asp Phe Glu His Trp Gly 
            100                 105                 110         


Arg Gly Thr Pro Val Ile Val Ser Ser 
        115                 120     


<210>  28
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant Antibody Sequence

<400>  28

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Thr Ala Ile Ile Ser Cys Arg Thr Ser Gln Tyr Gly Ser Leu Ala 
            20                  25                  30          


Trp Tyr Gln Gln Arg Pro Gly Gln Ala Pro Arg Leu Val Ile Tyr Ser 
        35                  40                  45              


Gly Ser Thr Arg Ala Ala Gly Ile Pro Asp Arg Phe Ser Gly Ser Arg 
    50                  55                  60                  


Trp Gly Pro Asp Tyr Asn Leu Thr Ile Ser Asn Leu Glu Ser Gly Asp 
65                  70                  75                  80  


Phe Gly Val Tyr Tyr Cys Gln Gln Tyr Glu Phe Phe Gly Gln Gly Thr 
                85                  90                  95      


Lys Val Gln Val Asp Ile Lys 
            100             


<210>  29
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant Antibody Sequence

<400>  29

Gln Val Arg Leu Ser Gln Ser Gly Gly Gln Met Lys Lys Pro Gly Asp 
1               5                   10                  15      


Ser Met Arg Ile Ser Cys Arg Ala Ser Gly Tyr Glu Phe Ile Asn Cys 
            20                  25                  30          


Pro Ile Asn Trp Ile Arg Leu Ala Pro Gly Lys Arg Pro Glu Trp Met 
        35                  40                  45              


Gly Trp Met Lys Pro Arg Gly Gly Ala Val Ser Tyr Ala Arg Gln Leu 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Met Tyr Ser Glu Thr Ala Phe 
65                  70                  75                  80  


Leu Glu Leu Arg Ser Leu Thr Ser Asp Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Thr Arg Gly Lys Tyr Cys Thr Ala Arg Asp Tyr Tyr Asn Trp Asp Phe 
            100                 105                 110         


Glu His Trp Gly Gln Gly Thr Pro Val Thr Val Ser Ser 
        115                 120                 125 


<210>  30
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant Antibody Sequence

<400>  30

Gln Val Arg Leu Ser Gln Ser Gly Gly Gln Met Lys Lys Pro Gly Asp 
1               5                   10                  15      


Ser Met Arg Ile Ser Cys Arg Ala Ser Gly Tyr Glu Phe Ile Asn Cys 
            20                  25                  30          


Pro Ile Asn Trp Ile Arg Leu Ala Pro Gly Lys Arg Pro Glu Trp Met 
        35                  40                  45              


Gly Trp Met Lys Pro Arg His Gly Ala Val Ser Tyr Ala Arg Gln Leu 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Met Tyr Ser Glu Thr Ala Phe 
65                  70                  75                  80  


Leu Glu Leu Arg Ser Leu Thr Ser Asp Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Thr Arg Gly Lys Tyr Cys Thr Ala Arg Asp Tyr Tyr Asn Trp Asp Phe 
            100                 105                 110         


Glu His Trp Gly Gln Gly Thr Pro Val Thr Val Ser Ser 
        115                 120                 125 


<210>  31
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant Antibody Sequence

<400>  31

Ser Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly Glu Thr 
1               5                   10                  15      


Ala Ile Ile Ser Cys Arg Thr Ser Gln Tyr Gly Ser Leu Ala Trp Tyr 
            20                  25                  30          


Gln Gln Arg Pro Gly Gln Ala Pro Arg Leu Val Ile Tyr Ser Gly Ser 
        35                  40                  45              


Thr Arg Ala Ala Gly Ile Pro Asp Arg Phe Ser Gly Ser Arg Trp Gly 
    50                  55                  60                  


Pro Asp Tyr Asn Leu Thr Ile Ser Asn Leu Glu Ser Gly Asp Phe Gly 
65                  70                  75                  80  


Val Tyr Tyr Cys Gln Gln Tyr Glu Phe Phe Gly Gln Gly Thr Lys Val 
                85                  90                  95      


Gln Val Asp Ile Lys 
            100     


<210>  32
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant Antibody Sequence

<400>  32

Gln Val Arg Leu Ser Gln Ser Gly Gly Gln Met Lys Lys Pro Gly Asp 
1               5                   10                  15      


Ser Met Arg Ile Ser Cys Arg Ala Ser Gly Tyr Glu Phe Ile Asn Cys 
            20                  25                  30          


Pro Ile Asn Trp Val Arg Leu Ala Pro Gly Lys Arg Pro Glu Trp Met 
        35                  40                  45              


Gly Trp Met Lys Pro Arg His Gly Ala Val Ser Tyr Ala Arg Gln Leu 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Met Tyr Ser Glu Thr Ala Phe 
65                  70                  75                  80  


Leu Glu Leu Arg Ser Leu Thr Ser Asp Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gly Lys Tyr Cys Thr Ala Arg Asp Tyr Tyr Asn Trp Asp Phe 
            100                 105                 110         


Glu His Trp Gly Gln Gly Thr Pro Val Thr Val Ser Ser 
        115                 120                 125 


<210>  33
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant Antibody Sequence

<400>  33

Ser Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly Glu Thr 
1               5                   10                  15      


Ala Ile Ile Ser Cys Arg Thr Ser Gln Tyr Gly Ser Leu Ala Trp Tyr 
            20                  25                  30          


Gln Gln Arg Pro Gly Gln Ala Pro Arg Leu Val Ile Tyr Ser Gly Ser 
        35                  40                  45              


Thr Arg Ala Ala Gly Ile Pro Asp Arg Phe Ser Gly Ser Arg Trp Gly 
    50                  55                  60                  


Pro Asp Tyr Asn Leu Thr Ile Ser Asn Leu Glu Ser Gly Asp Phe Gly 
65                  70                  75                  80  


Val Tyr Tyr Cys Gln Gln Tyr Glu Phe Phe Gly Gln Gly Thr Lys Val 
                85                  90                  95      


Gln Val Asp Ile Lys 
            100     


<210>  34
<211>  28
<212>  PRT
<213>  Human immunodeficiency virus type 1

<400>  34

Asn Glu Gln Glu Leu Leu Glu Leu Asp Lys Trp Ala Ser Leu Trp Asn 
1               5                   10                  15      


Trp Phe Asp Ile Thr Asn Trp Leu Trp Tyr Ile Arg 
            20                  25              


<210>  35
<211>  131
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant Antibody Sequence

<400>  35

Glu Val Arg Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Phe Asp Phe Asp Asn Ala 
            20                  25                  30          


Trp Met Thr Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Thr Gly Pro Gly Glu Gly Trp Ser Val Asp Tyr Ala Glu 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Thr Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Glu Met Asn Asn Val Arg Thr Glu Asp Thr Gly Tyr Tyr 
                85                  90                  95      


Phe Cys Ala Arg Thr Gly Lys Tyr Tyr Asp Phe Trp Trp Gly Tyr Pro 
            100                 105                 110         


Pro Gly Glu Glu Tyr Phe Gln Asp Trp Gly Gln Gly Thr Leu Val Ile 
        115                 120                 125             


Val Ser Ser 
    130     


<210>  36
<211>  131
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant Antibody Sequence

<400>  36

Glu Val Arg Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Phe Asp Phe Asp Asn Ala 
            20                  25                  30          


Trp Met Thr Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Thr Gly Pro Gly Glu Gly Trp Ser Val Asp Tyr Ala Glu 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Thr Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Glu Met Asn Asn Val Arg Thr Glu Asp Thr Gly Tyr Tyr 
                85                  90                  95      


Phe Cys Ala Arg Thr Gly Lys Tyr Tyr Asp Phe Trp Ser Gly Cys Pro 
            100                 105                 110         


Pro Gly Glu Glu Tyr Phe Gln Asp Trp Gly Gln Gly Thr Leu Val Ile 
        115                 120                 125             


Val Ser Ser 
    130     


<210>  37
<211>  131
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant Antibody Sequence

<400>  37

Glu Val Arg Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Phe Asp Phe Asp Asn Ala 
            20                  25                  30          


Trp Met Thr Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Thr Gly Pro Gly Glu Gly Trp Ser Val Asp Tyr Ala Glu 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Thr Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Glu Met Asn Asn Val Arg Thr Glu Asp Thr Gly Tyr Tyr 
                85                  90                  95      


Phe Cys Ala Arg Thr Gly Lys Tyr Tyr Asp Phe Trp Trp Gly Cys Pro 
            100                 105                 110         


Pro Gly Glu Glu Tyr Phe Gln Asp Trp Gly Gln Gly Thr Leu Val Ile 
        115                 120                 125             


Val Ser Ser 
    130     


<210>  38
<211>  131
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant Antibody Sequence

<400>  38

Glu Val Arg Leu Ala Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Phe Asp Phe Asp Asn Ala 
            20                  25                  30          


Trp Met Thr Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Thr Gly Pro Gly Glu Gly Trp Ser Val Asp Tyr Ala Ala 
    50                  55                  60                  


Pro Val Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Tyr Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Glu Met Asn Asn Leu Arg Thr Glu Asp Ser Gly Leu Tyr 
                85                  90                  95      


Phe Cys Ala Arg Thr Gly Lys Tyr Tyr Asp Phe Trp Trp Gly Tyr Pro 
            100                 105                 110         


Pro Gly Glu Glu Tyr Phe Gln Asp Trp Gly Arg Gly Thr Leu Val Ile 
        115                 120                 125             


Val Ser Ser 
    130     


<210>  39
<211>  131
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant Antibody Sequence

<400>  39

Glu Val Arg Leu Ala Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Phe Asp Phe Asp Asn Ala 
            20                  25                  30          


Trp Met Thr Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Thr Gly Pro Gly Glu Gly Trp Ser Val Asp Tyr Ala Ala 
    50                  55                  60                  


Pro Val Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Tyr Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Glu Met Asn Asn Leu Arg Thr Glu Asp Ser Gly Leu Tyr 
                85                  90                  95      


Phe Cys Ala Arg Thr Gly Lys Tyr Tyr Asp Phe Trp Ser Gly Cys Pro 
            100                 105                 110         


Pro Gly Glu Glu Tyr Phe Gln Asp Trp Gly Arg Gly Thr Leu Val Ile 
        115                 120                 125             


Val Ser Ser 
    130     


<210>  40
<211>  131
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant Antibody Sequence

<400>  40

Glu Val Arg Leu Ala Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Phe Asp Phe Asp Asn Ala 
            20                  25                  30          


Trp Met Thr Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Thr Gly Pro Gly Glu Gly Trp Ser Val Asp Tyr Ala Ala 
    50                  55                  60                  


Pro Val Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Tyr Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Glu Met Asn Asn Leu Arg Thr Glu Asp Ser Gly Leu Tyr 
                85                  90                  95      


Phe Cys Ala Arg Thr Gly Lys Tyr Tyr Asp Phe Trp Trp Gly Cys Pro 
            100                 105                 110         


Pro Gly Glu Glu Tyr Phe Gln Asp Trp Gly Arg Gly Thr Leu Val Ile 
        115                 120                 125             


Val Ser Ser 
    130     


<210>  41
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant Antibody Sequence

<400>  41

Ala Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Lys Gln 
1               5                   10                  15      


Thr Val Thr Ile Thr Cys Arg Gly Asp Ser Leu Arg Cys His Tyr Ala 
            20                  25                  30          


Ser Trp Tyr Gln Lys Lys Pro Gly Gln Ala Pro Val Leu Leu Phe Tyr 
        35                  40                  45              


Gly Lys Asn Asn Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  


Ala Ser Gly Asn Arg Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Arg Asp Lys Ser Gly Ser Arg 
                85                  90                  95      


Leu Ser Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  42
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant Antibody Sequence

<400>  42

Ala Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Lys Gln 
1               5                   10                  15      


Thr Val Thr Ile Thr Cys Arg Gly Asp Ser Leu Arg Ser His Trp Ala 
            20                  25                  30          


Ser Trp Tyr Gln Lys Lys Pro Gly Gln Ala Pro Val Leu Leu Phe Tyr 
        35                  40                  45              


Gly Lys Asn Asn Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  


Ala Ser Gly Asn Arg Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Arg Asp Lys Ser Gly Ser Arg 
                85                  90                  95      


Leu Ser Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  43
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant Antibody Sequence

<400>  43

Ala Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Lys Gln 
1               5                   10                  15      


Thr Val Thr Ile Thr Cys Arg Gly Asp Ser Leu Arg Ser His Phe Ala 
            20                  25                  30          


Ser Trp Tyr Gln Lys Lys Pro Gly Gln Ala Pro Val Leu Leu Phe Tyr 
        35                  40                  45              


Gly Lys Asn Asn Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  


Ala Ser Gly Asn Arg Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Arg Asp Lys Ser Gly Ser Arg 
                85                  90                  95      


Leu Ser Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  44
<211>  393
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant Antibody Sequence

<400>  44
gaagtgcggc tggctgagag cggcgggggg ctggtcaaac ctggcgggtc actgcggctg       60

tcctgttctg cctccggctt cgattttgat aacgcatgga tgacatgggt gcgacagcca      120

cctggaaagg ggctggagtg ggtcggcaga atcactggac ctggcgaagg gtggtctgtg      180

gactacgcag ctccagtcga gggacgattc accattagta gagataacta caagaataca      240

ctgtatctgg agatgaacaa tctgaggact gaagacagcg gcctgtattt ctgcgcccgc      300

accgggaaat actatgattt ttggtctggg tacccacccg gagaggaata ttttcaggac      360

tggggacggg gcaccctggt gatcgtcagc tcc                                   393


<210>  45
<211>  393
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant Antibody Sequence

<400>  45
gaggttagac tggtggagtc aggagggggg cttgtgaagc ccggtgggtc tctccgcctg       60

agctgttctg cctccggctt tgatttcgat aacgcctgga tgacctgggt caggcagcct      120

ccaggtaagg gactggagtg ggtgggaaga atcacaggtc caggcgaggg ctggtccgtg      180

gactacgcgg aatctgttaa agggcggttt acaatctcaa gggacaatac caagaatacc      240

ttgtatttgg agatgaacaa cgtgagaact gaagacaccg gatattactt ctgtgccaga      300

acaggcaaat actacgactt ctggtccggc tatccccctg gcgaggaata ttttcaagac      360

tggggtcagg gaacccttgt tatcgtgtcc tcc                                   393


<210>  46
<211>  327
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant Antibody Sequence

<400>  46
tcatacgaac tgactcagga cactggcgtc tctgtggcac tggggaggac tgtgactatt       60

acttgccgag gcgactcact gcggagccac tacgcttcct ggtatcagaa gaaacccggc      120

caggcacctg tgctgctgtt ctacggaaag aacaataggc catctggcat ccccgaccgc      180

ttttctggca gtgcatcagg gaaccgagcc agtctgacca ttaccggcgc ccaggctgag      240

gacgaagccg attactattg cagctcccgg gataagagcg gctccagact gagcgtgttc      300

ggaggaggaa ctaaactgac cgtcctc                                          327


<210>  47
<211>  390
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant Antibody Sequence

<400>  47
accaccatgg gatggtcatg tatcatcctt tttctagtag caactgcaac cggttctgtg       60

accgcatccg aactgactca ggaccctgcc gtctctgtgg cactgaagca gactgtgact      120

attacttgcc gaggcgactc actgcggagc cactacgctt cctggtatca gaagaaaccc      180

ggccaggcac ctgtgctgct gttctacgga aagaacaata ggccatctgg catccccgac      240

cgcttttctg gcagtgcatc agggaaccga gccagtctga ccattaccgg cgcccaggct      300

gaggacgaag ccgattacta ttgcagctcc cgggataaga gcggctccag actgagcgtg      360

ttcggaggag gaactaaact gaccgtcctc                                       390


<210>  48
<211>  5856
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant Antibody Sequence

<400>  48
tcgcgcgttt cggtgatgac ggtgaaaacc tctgacacat gcagctcccg gagacggtca       60

cagcttgtct gtaagcggat gccgggagca gacaagcccg tcagggcgcg tcagcgggtg      120

ttggcgggtg tcggggctgg cttaactatg cggcatcaga gcagattgta ctgagagtgc      180

accatatgcg gtgtgaaata ccgcacagat gcgtaaggag aaaataccgc atcagattgg      240

ctattggcca ttgcatacgt tgtatccata tcataatatg tacatttata ttggctcatg      300

tccaacatta ccgccatgtt gacattgatt attgactagt tattaatagt aatcaattac      360

ggggtcatta gttcatagcc catatatgga gttccgcgtt acataactta cggtaaatgg      420

cccgcctggc tgaccgccca acgacccccg cccattgacg tcaataatga cgtatgttcc      480

catagtaacg ccaataggga ctttccattg acgtcaatgg gtggagtatt tacggtaaac      540

tgcccacttg gcagtacatc aagtgtatca tatgccaagt acgcccccta ttgacgtcaa      600

tgacggtaaa tggcccgcct ggcattatgc ccagtacatg accttatggg actttcctac      660

ttggcagtac atctacgtat tagtcatcgc tattaccatg gtgatgcggt tttggcagta      720

catcaatggg cgtggatagc ggtttgactc acggggattt ccaagtctcc accccattga      780

cgtcaatggg agtttgtttt ggcaccaaaa tcaacgggac tttccaaaat gtcgtaacaa      840

ctccgcccca ttgacgcaaa tgggcggtag gcgtgtacgg tgggaggtct atataagcag      900

agctcgttta gtgaaccgtc agatcgcctg gagacgccat ccacgctgtt ttgacctcca      960

tagaagacac cgggaccgat ccagcctcca tcggctcgca tctctccttc acgcgcccgc     1020

cgccctacct gaggccgcca tccacgccgg ttgagtcgcg ttctgccgcc tcccgcctgt     1080

ggtgcctcct gaactgcgtc cgccgtctag gtaagtttaa agctcaggtc gagaccgggc     1140

ctttgtccgg cgctcccttg gagcctacct agactcagcc ggctctccac gctttgcctg     1200

accctgcttg ctcaactcta gttaacggtg gagggcagtg tagtctgagc agtactcgtt     1260

gctgccgcgc gcgccaccag acataatagc tgacagacta acagactgtt cctttccatg     1320

ggtcttttct gcagtcaccg tcgtcgacac gtgtgatcag atatcgcggc cgctctagac     1380

caccatggga tggtcatgta tcatcctttt tctagtagca actgcaaccg gtgtacattc     1440

tgaagtgcgg ctggctgaga gcggcggggg gctggtcaaa cctggcgggt cactgcggct     1500

gtcctgttct gcctccggct tcgattttga taacgcatgg atgacatggg tgcgacagcc     1560

acctggaaag gggctggagt gggtcggcag aatcactgga cctggcgaag ggtggtctgt     1620

ggactacgca gctccagtcg agggacgatt caccattagt agagataact acaagaatac     1680

actgtatctg gagatgaaca atctgaggac tgaagacagc ggcctgtatt tctgcgcccg     1740

caccgggaaa tactatgatt tttggtctgg gtacccaccc ggagaggaat attttcagga     1800

ctggggacgg ggcaccctgg tgatcgtcag ctccgcgtcg accaagggcc catcggtctt     1860

ccccctggca ccctcctcca agagcacctc tgggggcaca gcggccctgg gctgcctggt     1920

caaggactac ttccccgaac cggtgacggt gtcgtggaac tcaggcgccc tgaccagcgg     1980

cgtgcacacc ttcccggctg tcctacagtc ctcaggactc tactccctca gcagcgtggt     2040

gaccgtgccc tccagcagct tgggcaccca gacctacatc tgcaacgtga atcacaagcc     2100

cagcaacacc aaggtggaca agaaagttga gcccaaatct tgtgacaaaa ctcacacatg     2160

cccaccgtgc ccagcacctg aactcctggg gggaccgtca gtcttcctct tccccccaaa     2220

acccaaggac accctcatga tctcccggac ccctgaggtc acatgcgtgg tggtggacgt     2280

gagccacgaa gaccctgagg tcaagttcaa ctggtacgtg gacggcgtgg aggtgcataa     2340

tgccaagaca aagccgcggg aggagcagta caacagcacg taccgtgtgg tcagcgtcct     2400

caccgtcctg caccaggact ggctgaatgg caaggagtac aagtgcaagg tctccaacaa     2460

agccctccca gcccccatcg agaaaaccat ctccaaagcc aaagggcagc cccgagaacc     2520

acaggtgtac accctgcccc catcccggga tgagctgacc aagaaccagg tcagcctgac     2580

ctgcctggtc aaaggcttct atcccagcga catcgccgtg gagtgggaga gcaatgggca     2640

gccggagaac aactacaaga ccacgcctcc cgtgctggac tccgacggct ccttcttcct     2700

ctacagcaag ctcaccgtgg acaagagcag gtggcagcag gggaacgtct tctcatgctc     2760

cgtgatgcat gaggctctgc acaaccacta cacgcagaag agcctctccc tgtctccggg     2820

taaatgatga ggatccagat ctgctgtgcc ttctagttgc cagccatctg ttgtttgccc     2880

ctcccccgtg ccttccttga ccctggaagg tgccactccc actgtccttt cctaataaaa     2940

tgaggaaatt gcatcgcatt gtctgagtag gtgtcattct attctggggg gtggggtggg     3000

gcaggacagc aagggggagg attgggaaga caatagcagg catgctgggg atgcggtggg     3060

ctctatgggt acccaggtgc tgaagaattg acccggttcc tcctgggcca gaaagaagca     3120

ggcacatccc cttctctgtg acacaccctg tccacgcccc tggttcttag ttccagcccc     3180

actcatagga cactcatagc tcaggagggc tccgccttca atcccacccg ctaaagtact     3240

tggagcggtc tctccctccc tcatcagccc accaaaccaa acctagcctc caagagtggg     3300

aagaaattaa agcaagatag gctattaagt gcagagggag agaaaatgcc tccaacatgt     3360

gaggaagtaa tgagagaaat catagaattt taaggccatg atttaaggcc atcatggcct     3420

taatcttccg cttcctcgct cactgactcg ctgcgctcgg tcgttcggct gcggcgagcg     3480

gtatcagctc actcaaaggc ggtaatacgg ttatccacag aatcagggga taacgcagga     3540

aagaacatgt gagcaaaagg ccagcaaaag gccaggaacc gtaaaaaggc cgcgttgctg     3600

gcgtttttcc ataggctccg cccccctgac gagcatcaca aaaatcgacg ctcaagtcag     3660

aggtggcgaa acccgacagg actataaaga taccaggcgt ttccccctgg aagctccctc     3720

gtgcgctctc ctgttccgac cctgccgctt accggatacc tgtccgcctt tctcccttcg     3780

ggaagcgtgg cgctttctca tagctcacgc tgtaggtatc tcagttcggt gtaggtcgtt     3840

cgctccaagc tgggctgtgt gcacgaaccc cccgttcagc ccgaccgctg cgccttatcc     3900

ggtaactatc gtcttgagtc caacccggta agacacgact tatcgccact ggcagcagcc     3960

actggtaaca ggattagcag agcgaggtat gtaggcggtg ctacagagtt cttgaagtgg     4020

tggcctaact acggctacac tagaagaaca gtatttggta tctgcgctct gctgaagcca     4080

gttaccttcg gaaaaagagt tggtagctct tgatccggca aacaaaccac cgctggtagc     4140

ggtggttttt ttgtttgcaa gcagcagatt acgcgcagaa aaaaaggatc tcaagaagat     4200

cctttgatct tttctacggg gtctgacgct cagtggaacg aaaactcacg ttaagggatt     4260

ttggtcatga gattatcaaa aaggatcttc acctagatcc ttttaaatta aaaatgaagt     4320

tttaaatcaa tctaaagtat atatgagtaa acttggtctg acagttacca atgcttaatc     4380

agtgaggcac ctatctcagc gatctgtcta tttcgttcat ccatagttgc ctgactcggg     4440

gggggggggc gctgaggtct gcctcgtgaa gaaggtgttg ctgactcata ccaggcctga     4500

atcgccccat catccagcca gaaagtgagg gagccacggt tgatgagagc tttgttgtag     4560

gtggaccagt tggtgatttt gaacttttgc tttgccacgg aacggtctgc gttgtcggga     4620

agatgcgtga tctgatcctt caactcagca aaagttcgat ttattcaaca aagccgccgt     4680

cccgtcaagt cagcgtaatg ctctgccagt gttacaacca attaaccaat tctgattaga     4740

aaaactcatc gagcatcaaa tgaaactgca atttattcat atcaggatta tcaataccat     4800

atttttgaaa aagccgtttc tgtaatgaag gagaaaactc accgaggcag ttccatagga     4860

tggcaagatc ctggtatcgg tctgcgattc cgactcgtcc aacatcaata caacctatta     4920

atttcccctc gtcaaaaata aggttatcaa gtgagaaatc accatgagtg acgactgaat     4980

ccggtgagaa tggcaaaagc ttatgcattt ctttccagac ttgttcaaca ggccagccat     5040

tacgctcgtc atcaaaatca ctcgcatcaa ccaaaccgtt attcattcgt gattgcgcct     5100

gagcgagacg aaatacgcga tcgctgttaa aaggacaatt acaaacagga atcgaatgca     5160

accggcgcag gaacactgcc agcgcatcaa caatattttc acctgaatca ggatattctt     5220

ctaatacctg gaatgctgtt ttcccgggga tcgcagtggt gagtaaccat gcatcatcag     5280

gagtacggat aaaatgcttg atggtcggaa gaggcataaa ttccgtcagc cagtttagtc     5340

tgaccatctc atctgtaaca tcattggcaa cgctaccttt gccatgtttc agaaacaact     5400

ctggcgcatc gggcttccca tacaatcgat agattgtcgc acctgattgc ccgacattat     5460

cgcgagccca tttataccca tataaatcag catccatgtt ggaatttaat cgcggcctcg     5520

agcaagacgt ttcccgttga atatggctca taacacccct tgtattactg tttatgtaag     5580

cagacagttt tattgttcat gatgatatat ttttatcttg tgcaatgtaa catcagagat     5640

tttgagacac aacgtggctt tccccccccc cccattattg aagcatttat cagggttatt     5700

gtctcatgag cggatacata tttgaatgta tttagaaaaa taaacaaata ggggttccgc     5760

gcacatttcc ccgaaaagtg ccacctgacg tctaagaaac cattattatc atgacattaa     5820

cctataaaaa taggcgtatc acgaggccct ttcgtc                               5856


<210>  49
<211>  5856
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant Antibody Sequence

<400>  49
tcgcgcgttt cggtgatgac ggtgaaaacc tctgacacat gcagctcccg gagacggtca       60

cagcttgtct gtaagcggat gccgggagca gacaagcccg tcagggcgcg tcagcgggtg      120

ttggcgggtg tcggggctgg cttaactatg cggcatcaga gcagattgta ctgagagtgc      180

accatatgcg gtgtgaaata ccgcacagat gcgtaaggag aaaataccgc atcagattgg      240

ctattggcca ttgcatacgt tgtatccata tcataatatg tacatttata ttggctcatg      300

tccaacatta ccgccatgtt gacattgatt attgactagt tattaatagt aatcaattac      360

ggggtcatta gttcatagcc catatatgga gttccgcgtt acataactta cggtaaatgg      420

cccgcctggc tgaccgccca acgacccccg cccattgacg tcaataatga cgtatgttcc      480

catagtaacg ccaataggga ctttccattg acgtcaatgg gtggagtatt tacggtaaac      540

tgcccacttg gcagtacatc aagtgtatca tatgccaagt acgcccccta ttgacgtcaa      600

tgacggtaaa tggcccgcct ggcattatgc ccagtacatg accttatggg actttcctac      660

ttggcagtac atctacgtat tagtcatcgc tattaccatg gtgatgcggt tttggcagta      720

catcaatggg cgtggatagc ggtttgactc acggggattt ccaagtctcc accccattga      780

cgtcaatggg agtttgtttt ggcaccaaaa tcaacgggac tttccaaaat gtcgtaacaa      840

ctccgcccca ttgacgcaaa tgggcggtag gcgtgtacgg tgggaggtct atataagcag      900

agctcgttta gtgaaccgtc agatcgcctg gagacgccat ccacgctgtt ttgacctcca      960

tagaagacac cgggaccgat ccagcctcca tcggctcgca tctctccttc acgcgcccgc     1020

cgccctacct gaggccgcca tccacgccgg ttgagtcgcg ttctgccgcc tcccgcctgt     1080

ggtgcctcct gaactgcgtc cgccgtctag gtaagtttaa agctcaggtc gagaccgggc     1140

ctttgtccgg cgctcccttg gagcctacct agactcagcc ggctctccac gctttgcctg     1200

accctgcttg ctcaactcta gttaacggtg gagggcagtg tagtctgagc agtactcgtt     1260

gctgccgcgc gcgccaccag acataatagc tgacagacta acagactgtt cctttccatg     1320

ggtcttttct gcagtcaccg tcgtcgacac gtgtgatcag atatcgcggc cgctctagac     1380

caccatggga tggtcatgta tcatcctttt tctagtagca actgcaaccg gtgtacattc     1440

tgaggttaga ctggtggagt caggaggggg gcttgtgaag cccggtgggt ctctccgcct     1500

gagctgttct gcctccggct ttgatttcga taacgcctgg atgacctggg tcaggcagcc     1560

tccaggtaag ggactggagt gggtgggaag aatcacaggt ccaggcgagg gctggtccgt     1620

ggactacgcg gaatctgtta aagggcggtt tacaatctca agggacaata ccaagaatac     1680

cttgtatttg gagatgaaca acgtgagaac tgaagacacc ggatattact tctgtgccag     1740

aacaggcaaa tactacgact tctggtccgg ctatccccct ggcgaggaat attttcaaga     1800

ctggggtcag ggaacccttg ttatcgtgtc ctccgcgtcg accaagggcc catcggtctt     1860

ccccctggca ccctcctcca agagcacctc tgggggcaca gcggccctgg gctgcctggt     1920

caaggactac ttccccgaac cggtgacggt gtcgtggaac tcaggcgccc tgaccagcgg     1980

cgtgcacacc ttcccggctg tcctacagtc ctcaggactc tactccctca gcagcgtggt     2040

gaccgtgccc tccagcagct tgggcaccca gacctacatc tgcaacgtga atcacaagcc     2100

cagcaacacc aaggtggaca agaaagttga gcccaaatct tgtgacaaaa ctcacacatg     2160

cccaccgtgc ccagcacctg aactcctggg gggaccgtca gtcttcctct tccccccaaa     2220

acccaaggac accctcatga tctcccggac ccctgaggtc acatgcgtgg tggtggacgt     2280

gagccacgaa gaccctgagg tcaagttcaa ctggtacgtg gacggcgtgg aggtgcataa     2340

tgccaagaca aagccgcggg aggagcagta caacagcacg taccgtgtgg tcagcgtcct     2400

caccgtcctg caccaggact ggctgaatgg caaggagtac aagtgcaagg tctccaacaa     2460

agccctccca gcccccatcg agaaaaccat ctccaaagcc aaagggcagc cccgagaacc     2520

acaggtgtac accctgcccc catcccggga tgagctgacc aagaaccagg tcagcctgac     2580

ctgcctggtc aaaggcttct atcccagcga catcgccgtg gagtgggaga gcaatgggca     2640

gccggagaac aactacaaga ccacgcctcc cgtgctggac tccgacggct ccttcttcct     2700

ctacagcaag ctcaccgtgg acaagagcag gtggcagcag gggaacgtct tctcatgctc     2760

cgtgatgcat gaggctctgc acaaccacta cacgcagaag agcctctccc tgtctccggg     2820

taaatgatga ggatccagat ctgctgtgcc ttctagttgc cagccatctg ttgtttgccc     2880

ctcccccgtg ccttccttga ccctggaagg tgccactccc actgtccttt cctaataaaa     2940

tgaggaaatt gcatcgcatt gtctgagtag gtgtcattct attctggggg gtggggtggg     3000

gcaggacagc aagggggagg attgggaaga caatagcagg catgctgggg atgcggtggg     3060

ctctatgggt acccaggtgc tgaagaattg acccggttcc tcctgggcca gaaagaagca     3120

ggcacatccc cttctctgtg acacaccctg tccacgcccc tggttcttag ttccagcccc     3180

actcatagga cactcatagc tcaggagggc tccgccttca atcccacccg ctaaagtact     3240

tggagcggtc tctccctccc tcatcagccc accaaaccaa acctagcctc caagagtggg     3300

aagaaattaa agcaagatag gctattaagt gcagagggag agaaaatgcc tccaacatgt     3360

gaggaagtaa tgagagaaat catagaattt taaggccatg atttaaggcc atcatggcct     3420

taatcttccg cttcctcgct cactgactcg ctgcgctcgg tcgttcggct gcggcgagcg     3480

gtatcagctc actcaaaggc ggtaatacgg ttatccacag aatcagggga taacgcagga     3540

aagaacatgt gagcaaaagg ccagcaaaag gccaggaacc gtaaaaaggc cgcgttgctg     3600

gcgtttttcc ataggctccg cccccctgac gagcatcaca aaaatcgacg ctcaagtcag     3660

aggtggcgaa acccgacagg actataaaga taccaggcgt ttccccctgg aagctccctc     3720

gtgcgctctc ctgttccgac cctgccgctt accggatacc tgtccgcctt tctcccttcg     3780

ggaagcgtgg cgctttctca tagctcacgc tgtaggtatc tcagttcggt gtaggtcgtt     3840

cgctccaagc tgggctgtgt gcacgaaccc cccgttcagc ccgaccgctg cgccttatcc     3900

ggtaactatc gtcttgagtc caacccggta agacacgact tatcgccact ggcagcagcc     3960

actggtaaca ggattagcag agcgaggtat gtaggcggtg ctacagagtt cttgaagtgg     4020

tggcctaact acggctacac tagaagaaca gtatttggta tctgcgctct gctgaagcca     4080

gttaccttcg gaaaaagagt tggtagctct tgatccggca aacaaaccac cgctggtagc     4140

ggtggttttt ttgtttgcaa gcagcagatt acgcgcagaa aaaaaggatc tcaagaagat     4200

cctttgatct tttctacggg gtctgacgct cagtggaacg aaaactcacg ttaagggatt     4260

ttggtcatga gattatcaaa aaggatcttc acctagatcc ttttaaatta aaaatgaagt     4320

tttaaatcaa tctaaagtat atatgagtaa acttggtctg acagttacca atgcttaatc     4380

agtgaggcac ctatctcagc gatctgtcta tttcgttcat ccatagttgc ctgactcggg     4440

gggggggggc gctgaggtct gcctcgtgaa gaaggtgttg ctgactcata ccaggcctga     4500

atcgccccat catccagcca gaaagtgagg gagccacggt tgatgagagc tttgttgtag     4560

gtggaccagt tggtgatttt gaacttttgc tttgccacgg aacggtctgc gttgtcggga     4620

agatgcgtga tctgatcctt caactcagca aaagttcgat ttattcaaca aagccgccgt     4680

cccgtcaagt cagcgtaatg ctctgccagt gttacaacca attaaccaat tctgattaga     4740

aaaactcatc gagcatcaaa tgaaactgca atttattcat atcaggatta tcaataccat     4800

atttttgaaa aagccgtttc tgtaatgaag gagaaaactc accgaggcag ttccatagga     4860

tggcaagatc ctggtatcgg tctgcgattc cgactcgtcc aacatcaata caacctatta     4920

atttcccctc gtcaaaaata aggttatcaa gtgagaaatc accatgagtg acgactgaat     4980

ccggtgagaa tggcaaaagc ttatgcattt ctttccagac ttgttcaaca ggccagccat     5040

tacgctcgtc atcaaaatca ctcgcatcaa ccaaaccgtt attcattcgt gattgcgcct     5100

gagcgagacg aaatacgcga tcgctgttaa aaggacaatt acaaacagga atcgaatgca     5160

accggcgcag gaacactgcc agcgcatcaa caatattttc acctgaatca ggatattctt     5220

ctaatacctg gaatgctgtt ttcccgggga tcgcagtggt gagtaaccat gcatcatcag     5280

gagtacggat aaaatgcttg atggtcggaa gaggcataaa ttccgtcagc cagtttagtc     5340

tgaccatctc atctgtaaca tcattggcaa cgctaccttt gccatgtttc agaaacaact     5400

ctggcgcatc gggcttccca tacaatcgat agattgtcgc acctgattgc ccgacattat     5460

cgcgagccca tttataccca tataaatcag catccatgtt ggaatttaat cgcggcctcg     5520

agcaagacgt ttcccgttga atatggctca taacacccct tgtattactg tttatgtaag     5580

cagacagttt tattgttcat gatgatatat ttttatcttg tgcaatgtaa catcagagat     5640

tttgagacac aacgtggctt tccccccccc cccattattg aagcatttat cagggttatt     5700

gtctcatgag cggatacata tttgaatgta tttagaaaaa taaacaaata ggggttccgc     5760

gcacatttcc ccgaaaagtg ccacctgacg tctaagaaac cattattatc atgacattaa     5820

cctataaaaa taggcgtatc acgaggccct ttcgtc                               5856


<210>  50
<211>  5119
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant Antibody Sequence

<400>  50
tcgcgcgttt cggtgatgac ggtgaaaacc tctgacacat gcagctcccg gagacggtca       60

cagcttgtct gtaagcggat gccgggagca gacaagcccg tcagggcgcg tcagcgggtg      120

ttggcgggtg tcggggctgg cttaactatg cggcatcaga gcagattgta ctgagagtgc      180

accatatgcg gtgtgaaata ccgcacagat gcgtaaggag aaaataccgc atcagattgg      240

ctattggcca ttgcatacgt tgtatccata tcataatatg tacatttata ttggctcatg      300

tccaacatta ccgccatgtt gacattgatt attgactagt tattaatagt aatcaattac      360

ggggtcatta gttcatagcc catatatgga gttccgcgtt acataactta cggtaaatgg      420

cccgcctggc tgaccgccca acgacccccg cccattgacg tcaataatga cgtatgttcc      480

catagtaacg ccaataggga ctttccattg acgtcaatgg gtggagtatt tacggtaaac      540

tgcccacttg gcagtacatc aagtgtatca tatgccaagt acgcccccta ttgacgtcaa      600

tgacggtaaa tggcccgcct ggcattatgc ccagtacatg accttatggg actttcctac      660

ttggcagtac atctacgtat tagtcatcgc tattaccatg gtgatgcggt tttggcagta      720

catcaatggg cgtggatagc ggtttgactc acggggattt ccaagtctcc accccattga      780

cgtcaatggg agtttgtttt ggcaccaaaa tcaacgggac tttccaaaat gtcgtaacaa      840

ctccgcccca ttgacgcaaa tgggcggtag gcgtgtacgg tgggaggtct atataagcag      900

agctcgttta gtgaaccgtc agatcgcctg gagacgccat ccacgctgtt ttgacctcca      960

tagaagacac cgggaccgat ccagcctcca tcggctcgca tctctccttc acgcgcccgc     1020

cgccctacct gaggccgcca tccacgccgg ttgagtcgcg ttctgccgcc tcccgcctgt     1080

ggtgcctcct gaactgcgtc cgccgtctag gtaagtttaa agctcaggtc gagaccgggc     1140

ctttgtccgg cgctcccttg gagcctacct agactcagcc ggctctccac gctttgcctg     1200

accctgcttg ctcaactcta gttaacggtg gagggcagtg tagtctgagc agtactcgtt     1260

gctgccgcgc gcgccaccag acataatagc tgacagacta acagactgtt cctttccatg     1320

ggtcttttct gcagtcaccg tcgtcgacac gtgtgatcag atatcgcggc cgctctagac     1380

caccatggga tggtcatgta tcatcctttt tctagtagca actgcaaccg gttctgtgac     1440

ctcatacgaa ctgactcagg acactggcgt ctctgtggca ctggggagga ctgtgactat     1500

tacttgccga ggcgactcac tgcggagcca ctacgcttcc tggtatcaga agaaacccgg     1560

ccaggcacct gtgctgctgt tctacggaaa gaacaatagg ccatctggca tccccgaccg     1620

cttttctggc agtgcatcag ggaaccgagc cagtctgacc attaccggcg cccaggctga     1680

ggacgaagcc gattactatt gcagctcccg ggataagagc ggctccagac tgagcgtgtt     1740

cggaggagga actaaactga ccgtcctcag tcagcccaag gctgccccct cggtcactct     1800

gttcccgccc tcgagtgagg agcttcaagc caacaaggcc acactggtgt gtctcataag     1860

tgacttctac ccgggagccg tgacagtggc ctggaaggca gatagcagcc ccgtcaaggc     1920

gggagtggag accaccacac cctccaaaca aagcaacaac aagtacgcgg ccagcagcta     1980

cctgagcctg acgcctgagc agtggaagtc ccacagaagc tacagctgcc aggtcacgca     2040

tgaagggagc accgtggaga agacagtggc ccctacagaa tgttcataga agctgatcca     2100

gatctgctgt gccttctagt tgccagccat ctgttgtttg cccctccccc gtgccttcct     2160

tgaccctgga aggtgccact cccactgtcc tttcctaata aaatgaggaa attgcatcgc     2220

attgtctgag taggtgtcat tctattctgg ggggtggggt ggggcaggac agcaaggggg     2280

aggattggga agacaatagc aggcatgctg gggatgcggt gggctctatg ggtacccagg     2340

tgctgaagaa ttgacccggt tcctcctggg ccagaaagaa gcaggcacat ccccttctct     2400

gtgacacacc ctgtccacgc ccctggttct tagttccagc cccactcata ggacactcat     2460

agctcaggag ggctccgcct tcaatcccac ccgctaaagt acttggagcg gtctctccct     2520

ccctcatcag cccaccaaac caaacctagc ctccaagagt gggaagaaat taaagcaaga     2580

taggctatta agtgcagagg gagagaaaat gcctccaaca tgtgaggaag taatgagaga     2640

aatcatagaa ttttaaggcc atgatttaag gccatcatgg ccttaatctt ccgcttcctc     2700

gctcactgac tcgctgcgct cggtcgttcg gctgcggcga gcggtatcag ctcactcaaa     2760

ggcggtaata cggttatcca cagaatcagg ggataacgca ggaaagaaca tgtgagcaaa     2820

aggccagcaa aaggccagga accgtaaaaa ggccgcgttg ctggcgtttt tccataggct     2880

ccgcccccct gacgagcatc acaaaaatcg acgctcaagt cagaggtggc gaaacccgac     2940

aggactataa agataccagg cgtttccccc tggaagctcc ctcgtgcgct ctcctgttcc     3000

gaccctgccg cttaccggat acctgtccgc ctttctccct tcgggaagcg tggcgctttc     3060

tcatagctca cgctgtaggt atctcagttc ggtgtaggtc gttcgctcca agctgggctg     3120

tgtgcacgaa ccccccgttc agcccgaccg ctgcgcctta tccggtaact atcgtcttga     3180

gtccaacccg gtaagacacg acttatcgcc actggcagca gccactggta acaggattag     3240

cagagcgagg tatgtaggcg gtgctacaga gttcttgaag tggtggccta actacggcta     3300

cactagaaga acagtatttg gtatctgcgc tctgctgaag ccagttacct tcggaaaaag     3360

agttggtagc tcttgatccg gcaaacaaac caccgctggt agcggtggtt tttttgtttg     3420

caagcagcag attacgcgca gaaaaaaagg atctcaagaa gatcctttga tcttttctac     3480

ggggtctgac gctcagtgga acgaaaactc acgttaaggg attttggtca tgagattatc     3540

aaaaaggatc ttcacctaga tccttttaaa ttaaaaatga agttttaaat caatctaaag     3600

tatatatgag taaacttggt ctgacagtta ccaatgctta atcagtgagg cacctatctc     3660

agcgatctgt ctatttcgtt catccatagt tgcctgactc gggggggggg ggcgctgagg     3720

tctgcctcgt gaagaaggtg ttgctgactc ataccaggcc tgaatcgccc catcatccag     3780

ccagaaagtg agggagccac ggttgatgag agctttgttg taggtggacc agttggtgat     3840

tttgaacttt tgctttgcca cggaacggtc tgcgttgtcg ggaagatgcg tgatctgatc     3900

cttcaactca gcaaaagttc gatttattca acaaagccgc cgtcccgtca agtcagcgta     3960

atgctctgcc agtgttacaa ccaattaacc aattctgatt agaaaaactc atcgagcatc     4020

aaatgaaact gcaatttatt catatcagga ttatcaatac catatttttg aaaaagccgt     4080

ttctgtaatg aaggagaaaa ctcaccgagg cagttccata ggatggcaag atcctggtat     4140

cggtctgcga ttccgactcg tccaacatca atacaaccta ttaatttccc ctcgtcaaaa     4200

ataaggttat caagtgagaa atcaccatga gtgacgactg aatccggtga gaatggcaaa     4260

agcttatgca tttctttcca gacttgttca acaggccagc cattacgctc gtcatcaaaa     4320

tcactcgcat caaccaaacc gttattcatt cgtgattgcg cctgagcgag acgaaatacg     4380

cgatcgctgt taaaaggaca attacaaaca ggaatcgaat gcaaccggcg caggaacact     4440

gccagcgcat caacaatatt ttcacctgaa tcaggatatt cttctaatac ctggaatgct     4500

gttttcccgg ggatcgcagt ggtgagtaac catgcatcat caggagtacg gataaaatgc     4560

ttgatggtcg gaagaggcat aaattccgtc agccagttta gtctgaccat ctcatctgta     4620

acatcattgg caacgctacc tttgccatgt ttcagaaaca actctggcgc atcgggcttc     4680

ccatacaatc gatagattgt cgcacctgat tgcccgacat tatcgcgagc ccatttatac     4740

ccatataaat cagcatccat gttggaattt aatcgcggcc tcgagcaaga cgtttcccgt     4800

tgaatatggc tcataacacc ccttgtatta ctgtttatgt aagcagacag ttttattgtt     4860

catgatgata tatttttatc ttgtgcaatg taacatcaga gattttgaga cacaacgtgg     4920

ctttcccccc ccccccatta ttgaagcatt tatcagggtt attgtctcat gagcggatac     4980

atatttgaat gtatttagaa aaataaacaa ataggggttc cgcgcacatt tccccgaaaa     5040

gtgccacctg acgtctaaga aaccattatt atcatgacat taacctataa aaataggcgt     5100

atcacgaggc cctttcgtc                                                  5119


<210>  51
<211>  5119
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant Antibody Sequence

<400>  51
tcgcgcgttt cggtgatgac ggtgaaaacc tctgacacat gcagctcccg gagacggtca       60

cagcttgtct gtaagcggat gccgggagca gacaagcccg tcagggcgcg tcagcgggtg      120

ttggcgggtg tcggggctgg cttaactatg cggcatcaga gcagattgta ctgagagtgc      180

accatatgcg gtgtgaaata ccgcacagat gcgtaaggag aaaataccgc atcagattgg      240

ctattggcca ttgcatacgt tgtatccata tcataatatg tacatttata ttggctcatg      300

tccaacatta ccgccatgtt gacattgatt attgactagt tattaatagt aatcaattac      360

ggggtcatta gttcatagcc catatatgga gttccgcgtt acataactta cggtaaatgg      420

cccgcctggc tgaccgccca acgacccccg cccattgacg tcaataatga cgtatgttcc      480

catagtaacg ccaataggga ctttccattg acgtcaatgg gtggagtatt tacggtaaac      540

tgcccacttg gcagtacatc aagtgtatca tatgccaagt acgcccccta ttgacgtcaa      600

tgacggtaaa tggcccgcct ggcattatgc ccagtacatg accttatggg actttcctac      660

ttggcagtac atctacgtat tagtcatcgc tattaccatg gtgatgcggt tttggcagta      720

catcaatggg cgtggatagc ggtttgactc acggggattt ccaagtctcc accccattga      780

cgtcaatggg agtttgtttt ggcaccaaaa tcaacgggac tttccaaaat gtcgtaacaa      840

ctccgcccca ttgacgcaaa tgggcggtag gcgtgtacgg tgggaggtct atataagcag      900

agctcgttta gtgaaccgtc agatcgcctg gagacgccat ccacgctgtt ttgacctcca      960

tagaagacac cgggaccgat ccagcctcca tcggctcgca tctctccttc acgcgcccgc     1020

cgccctacct gaggccgcca tccacgccgg ttgagtcgcg ttctgccgcc tcccgcctgt     1080

ggtgcctcct gaactgcgtc cgccgtctag gtaagtttaa agctcaggtc gagaccgggc     1140

ctttgtccgg cgctcccttg gagcctacct agactcagcc ggctctccac gctttgcctg     1200

accctgcttg ctcaactcta gttaacggtg gagggcagtg tagtctgagc agtactcgtt     1260

gctgccgcgc gcgccaccag acataatagc tgacagacta acagactgtt cctttccatg     1320

ggtcttttct gcagtcaccg tcgtcgacac gtgtgatcag atatcgcggc cgctctagac     1380

caccatggga tggtcatgta tcatcctttt tctagtagca actgcaaccg gttctgtgac     1440

cgcatccgaa ctgactcagg accctgccgt ctctgtggca ctgaagcaga ctgtgactat     1500

tacttgccga ggcgactcac tgcggagcca ctacgcttcc tggtatcaga agaaacccgg     1560

ccaggcacct gtgctgctgt tctacggaaa gaacaatagg ccatctggca tccccgaccg     1620

cttttctggc agtgcatcag ggaaccgagc cagtctgacc attaccggcg cccaggctga     1680

ggacgaagcc gattactatt gcagctcccg ggataagagc ggctccagac tgagcgtgtt     1740

cggaggagga actaaactga ccgtcctcag tcagcccaag gctgccccct cggtcactct     1800

gttcccgccc tcgagtgagg agcttcaagc caacaaggcc acactggtgt gtctcataag     1860

tgacttctac ccgggagccg tgacagtggc ctggaaggca gatagcagcc ccgtcaaggc     1920

gggagtggag accaccacac cctccaaaca aagcaacaac aagtacgcgg ccagcagcta     1980

cctgagcctg acgcctgagc agtggaagtc ccacagaagc tacagctgcc aggtcacgca     2040

tgaagggagc accgtggaga agacagtggc ccctacagaa tgttcataga agctgatcca     2100

gatctgctgt gccttctagt tgccagccat ctgttgtttg cccctccccc gtgccttcct     2160

tgaccctgga aggtgccact cccactgtcc tttcctaata aaatgaggaa attgcatcgc     2220

attgtctgag taggtgtcat tctattctgg ggggtggggt ggggcaggac agcaaggggg     2280

aggattggga agacaatagc aggcatgctg gggatgcggt gggctctatg ggtacccagg     2340

tgctgaagaa ttgacccggt tcctcctggg ccagaaagaa gcaggcacat ccccttctct     2400

gtgacacacc ctgtccacgc ccctggttct tagttccagc cccactcata ggacactcat     2460

agctcaggag ggctccgcct tcaatcccac ccgctaaagt acttggagcg gtctctccct     2520

ccctcatcag cccaccaaac caaacctagc ctccaagagt gggaagaaat taaagcaaga     2580

taggctatta agtgcagagg gagagaaaat gcctccaaca tgtgaggaag taatgagaga     2640

aatcatagaa ttttaaggcc atgatttaag gccatcatgg ccttaatctt ccgcttcctc     2700

gctcactgac tcgctgcgct cggtcgttcg gctgcggcga gcggtatcag ctcactcaaa     2760

ggcggtaata cggttatcca cagaatcagg ggataacgca ggaaagaaca tgtgagcaaa     2820

aggccagcaa aaggccagga accgtaaaaa ggccgcgttg ctggcgtttt tccataggct     2880

ccgcccccct gacgagcatc acaaaaatcg acgctcaagt cagaggtggc gaaacccgac     2940

aggactataa agataccagg cgtttccccc tggaagctcc ctcgtgcgct ctcctgttcc     3000

gaccctgccg cttaccggat acctgtccgc ctttctccct tcgggaagcg tggcgctttc     3060

tcatagctca cgctgtaggt atctcagttc ggtgtaggtc gttcgctcca agctgggctg     3120

tgtgcacgaa ccccccgttc agcccgaccg ctgcgcctta tccggtaact atcgtcttga     3180

gtccaacccg gtaagacacg acttatcgcc actggcagca gccactggta acaggattag     3240

cagagcgagg tatgtaggcg gtgctacaga gttcttgaag tggtggccta actacggcta     3300

cactagaaga acagtatttg gtatctgcgc tctgctgaag ccagttacct tcggaaaaag     3360

agttggtagc tcttgatccg gcaaacaaac caccgctggt agcggtggtt tttttgtttg     3420

caagcagcag attacgcgca gaaaaaaagg atctcaagaa gatcctttga tcttttctac     3480

ggggtctgac gctcagtgga acgaaaactc acgttaaggg attttggtca tgagattatc     3540

aaaaaggatc ttcacctaga tccttttaaa ttaaaaatga agttttaaat caatctaaag     3600

tatatatgag taaacttggt ctgacagtta ccaatgctta atcagtgagg cacctatctc     3660

agcgatctgt ctatttcgtt catccatagt tgcctgactc gggggggggg ggcgctgagg     3720

tctgcctcgt gaagaaggtg ttgctgactc ataccaggcc tgaatcgccc catcatccag     3780

ccagaaagtg agggagccac ggttgatgag agctttgttg taggtggacc agttggtgat     3840

tttgaacttt tgctttgcca cggaacggtc tgcgttgtcg ggaagatgcg tgatctgatc     3900

cttcaactca gcaaaagttc gatttattca acaaagccgc cgtcccgtca agtcagcgta     3960

atgctctgcc agtgttacaa ccaattaacc aattctgatt agaaaaactc atcgagcatc     4020

aaatgaaact gcaatttatt catatcagga ttatcaatac catatttttg aaaaagccgt     4080

ttctgtaatg aaggagaaaa ctcaccgagg cagttccata ggatggcaag atcctggtat     4140

cggtctgcga ttccgactcg tccaacatca atacaaccta ttaatttccc ctcgtcaaaa     4200

ataaggttat caagtgagaa atcaccatga gtgacgactg aatccggtga gaatggcaaa     4260

agcttatgca tttctttcca gacttgttca acaggccagc cattacgctc gtcatcaaaa     4320

tcactcgcat caaccaaacc gttattcatt cgtgattgcg cctgagcgag acgaaatacg     4380

cgatcgctgt taaaaggaca attacaaaca ggaatcgaat gcaaccggcg caggaacact     4440

gccagcgcat caacaatatt ttcacctgaa tcaggatatt cttctaatac ctggaatgct     4500

gttttcccgg ggatcgcagt ggtgagtaac catgcatcat caggagtacg gataaaatgc     4560

ttgatggtcg gaagaggcat aaattccgtc agccagttta gtctgaccat ctcatctgta     4620

acatcattgg caacgctacc tttgccatgt ttcagaaaca actctggcgc atcgggcttc     4680

ccatacaatc gatagattgt cgcacctgat tgcccgacat tatcgcgagc ccatttatac     4740

ccatataaat cagcatccat gttggaattt aatcgcggcc tcgagcaaga cgtttcccgt     4800

tgaatatggc tcataacacc ccttgtatta ctgtttatgt aagcagacag ttttattgtt     4860

catgatgata tatttttatc ttgtgcaatg taacatcaga gattttgaga cacaacgtgg     4920

ctttcccccc ccccccatta ttgaagcatt tatcagggtt attgtctcat gagcggatac     4980

atatttgaat gtatttagaa aaataaacaa ataggggttc cgcgcacatt tccccgaaaa     5040

gtgccacctg acgtctaaga aaccattatt atcatgacat taacctataa aaataggcgt     5100

atcacgaggc cctttcgtc                                                  5119


<210>  52
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant Antibody Sequence

<400>  52

Ala Arg Thr Gly Lys Tyr Tyr Asp Phe Trp Trp Gly Tyr Pro Pro Gly 
1               5                   10                  15      


Glu Glu Tyr Phe Gln Asp 
            20          


<210>  53
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant Antibody Sequence

<400>  53

Ala Arg Thr Gly Lys Tyr Tyr Asp Phe Trp Ser Gly Cys Pro Pro Gly 
1               5                   10                  15      


Glu Glu Tyr Phe Gln Asp 
            20          


<210>  54
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant Antibody Sequence

<400>  54

Ala Arg Thr Gly Lys Tyr Tyr Asp Phe Trp Trp Gly Cys Pro Pro Gly 
1               5                   10                  15      


Glu Glu Tyr Phe Gln Asp 
            20          


<210>  55
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant Antibody Sequence

<400>  55

Ser Leu Arg Cys His Tyr 
1               5       


<210>  56
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant Antibody Sequence

<400>  56

Ser Leu Arg Ser His Trp 
1               5       


<210>  57
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant Antibody Sequence

<400>  57

Ser Leu Arg Ser His Phe 
1               5       


<210>  58
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant Antibody Sequence

<400>  58

Ala Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Lys Gln 
1               5                   10                  15      


Thr Val Thr Ile Thr Cys Arg Gly Asp Ser Leu Arg Cys His Trp Ala 
            20                  25                  30          


Ser Trp Tyr Gln Lys Lys Pro Gly Gln Ala Pro Val Leu Leu Phe Tyr 
        35                  40                  45              


Gly Lys Asn Asn Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  


Ala Ser Gly Asn Arg Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Arg Asp Lys Ser Gly Ser Arg 
                85                  90                  95      


Leu Ser Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  59
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant Antibody Sequence

<400>  59

Ala Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Lys Gln 
1               5                   10                  15      


Thr Val Thr Ile Thr Cys Arg Gly Asp Ser Leu Arg Cys His Phe Ala 
            20                  25                  30          


Ser Trp Tyr Gln Lys Lys Pro Gly Gln Ala Pro Val Leu Leu Phe Tyr 
        35                  40                  45              


Gly Lys Asn Asn Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  


Ala Ser Gly Asn Arg Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Arg Asp Lys Ser Gly Ser Arg 
                85                  90                  95      


Leu Ser Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  60
<211>  5856
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant Antibody Sequence

<400>  60
tcgcgcgttt cggtgatgac ggtgaaaacc tctgacacat gcagctcccg gagacggtca       60

cagcttgtct gtaagcggat gccgggagca gacaagcccg tcagggcgcg tcagcgggtg      120

ttggcgggtg tcggggctgg cttaactatg cggcatcaga gcagattgta ctgagagtgc      180

accatatgcg gtgtgaaata ccgcacagat gcgtaaggag aaaataccgc atcagattgg      240

ctattggcca ttgcatacgt tgtatccata tcataatatg tacatttata ttggctcatg      300

tccaacatta ccgccatgtt gacattgatt attgactagt tattaatagt aatcaattac      360

ggggtcatta gttcatagcc catatatgga gttccgcgtt acataactta cggtaaatgg      420

cccgcctggc tgaccgccca acgacccccg cccattgacg tcaataatga cgtatgttcc      480

catagtaacg ccaataggga ctttccattg acgtcaatgg gtggagtatt tacggtaaac      540

tgcccacttg gcagtacatc aagtgtatca tatgccaagt acgcccccta ttgacgtcaa      600

tgacggtaaa tggcccgcct ggcattatgc ccagtacatg accttatggg actttcctac      660

ttggcagtac atctacgtat tagtcatcgc tattaccatg gtgatgcggt tttggcagta      720

catcaatggg cgtggatagc ggtttgactc acggggattt ccaagtctcc accccattga      780

cgtcaatggg agtttgtttt ggcaccaaaa tcaacgggac tttccaaaat gtcgtaacaa      840

ctccgcccca ttgacgcaaa tgggcggtag gcgtgtacgg tgggaggtct atataagcag      900

agctcgttta gtgaaccgtc agatcgcctg gagacgccat ccacgctgtt ttgacctcca      960

tagaagacac cgggaccgat ccagcctcca tcggctcgca tctctccttc acgcgcccgc     1020

cgccctacct gaggccgcca tccacgccgg ttgagtcgcg ttctgccgcc tcccgcctgt     1080

ggtgcctcct gaactgcgtc cgccgtctag gtaagtttaa agctcaggtc gagaccgggc     1140

ctttgtccgg cgctcccttg gagcctacct agactcagcc ggctctccac gctttgcctg     1200

accctgcttg ctcaactcta gttaacggtg gagggcagtg tagtctgagc agtactcgtt     1260

gctgccgcgc gcgccaccag acataatagc tgacagacta acagactgtt cctttccatg     1320

ggtcttttct gcagtcaccg tcgtcgacac gtgtgatcag atatcgcggc cgctctagac     1380

caccatggga tggtcatgta tcatcctttt tctagtagca actgcaaccg gtgtacattc     1440

tgaggttaga ctggtggagt caggaggggg gcttgtgaag cccggtgggt ctctccgcct     1500

gagctgttct gcctccggct ttgatttcga taacgcctgg atgacctggg tcaggcagcc     1560

tccaggtaag ggactggagt gggtgggaag aatcacaggt ccaggcgagg gctggtccgt     1620

ggactacgcg gaatctgtta aagggcggtt tacaatctca agggacaata ccaagaatac     1680

cttgtatttg gagatgaaca acgtgagaac tgaagacacc ggatattact tctgtgccag     1740

aacaggcaaa tactacgact tctggtccgg ctgcccccct ggcgaggaat attttcaaga     1800

ctggggtcag ggaacccttg ttatcgtgtc ctccgcgtcg accaagggcc catcggtctt     1860

ccccctggca ccctcctcca agagcacctc tgggggcaca gcggccctgg gctgcctggt     1920

caaggactac ttccccgaac cggtgacggt gtcgtggaac tcaggcgccc tgaccagcgg     1980

cgtgcacacc ttcccggctg tcctacagtc ctcaggactc tactccctca gcagcgtggt     2040

gaccgtgccc tccagcagct tgggcaccca gacctacatc tgcaacgtga atcacaagcc     2100

cagcaacacc aaggtggaca agaaagttga gcccaaatct tgtgacaaaa ctcacacatg     2160

cccaccgtgc ccagcacctg aactcctggg gggaccgtca gtcttcctct tccccccaaa     2220

acccaaggac accctcatga tctcccggac ccctgaggtc acatgcgtgg tggtggacgt     2280

gagccacgaa gaccctgagg tcaagttcaa ctggtacgtg gacggcgtgg aggtgcataa     2340

tgccaagaca aagccgcggg aggagcagta caacagcacg taccgtgtgg tcagcgtcct     2400

caccgtcctg caccaggact ggctgaatgg caaggagtac aagtgcaagg tctccaacaa     2460

agccctccca gcccccatcg agaaaaccat ctccaaagcc aaagggcagc cccgagaacc     2520

acaggtgtac accctgcccc catcccggga tgagctgacc aagaaccagg tcagcctgac     2580

ctgcctggtc aaaggcttct atcccagcga catcgccgtg gagtgggaga gcaatgggca     2640

gccggagaac aactacaaga ccacgcctcc cgtgctggac tccgacggct ccttcttcct     2700

ctacagcaag ctcaccgtgg acaagagcag gtggcagcag gggaacgtct tctcatgctc     2760

cgtgatgcat gaggctctgc acaaccacta cacgcagaag agcctctccc tgtctccggg     2820

taaatgatga ggatccagat ctgctgtgcc ttctagttgc cagccatctg ttgtttgccc     2880

ctcccccgtg ccttccttga ccctggaagg tgccactccc actgtccttt cctaataaaa     2940

tgaggaaatt gcatcgcatt gtctgagtag gtgtcattct attctggggg gtggggtggg     3000

gcaggacagc aagggggagg attgggaaga caatagcagg catgctgggg atgcggtggg     3060

ctctatgggt acccaggtgc tgaagaattg acccggttcc tcctgggcca gaaagaagca     3120

ggcacatccc cttctctgtg acacaccctg tccacgcccc tggttcttag ttccagcccc     3180

actcatagga cactcatagc tcaggagggc tccgccttca atcccacccg ctaaagtact     3240

tggagcggtc tctccctccc tcatcagccc accaaaccaa acctagcctc caagagtggg     3300

aagaaattaa agcaagatag gctattaagt gcagagggag agaaaatgcc tccaacatgt     3360

gaggaagtaa tgagagaaat catagaattt taaggccatg atttaaggcc atcatggcct     3420

taatcttccg cttcctcgct cactgactcg ctgcgctcgg tcgttcggct gcggcgagcg     3480

gtatcagctc actcaaaggc ggtaatacgg ttatccacag aatcagggga taacgcagga     3540

aagaacatgt gagcaaaagg ccagcaaaag gccaggaacc gtaaaaaggc cgcgttgctg     3600

gcgtttttcc ataggctccg cccccctgac gagcatcaca aaaatcgacg ctcaagtcag     3660

aggtggcgaa acccgacagg actataaaga taccaggcgt ttccccctgg aagctccctc     3720

gtgcgctctc ctgttccgac cctgccgctt accggatacc tgtccgcctt tctcccttcg     3780

ggaagcgtgg cgctttctca tagctcacgc tgtaggtatc tcagttcggt gtaggtcgtt     3840

cgctccaagc tgggctgtgt gcacgaaccc cccgttcagc ccgaccgctg cgccttatcc     3900

ggtaactatc gtcttgagtc caacccggta agacacgact tatcgccact ggcagcagcc     3960

actggtaaca ggattagcag agcgaggtat gtaggcggtg ctacagagtt cttgaagtgg     4020

tggcctaact acggctacac tagaagaaca gtatttggta tctgcgctct gctgaagcca     4080

gttaccttcg gaaaaagagt tggtagctct tgatccggca aacaaaccac cgctggtagc     4140

ggtggttttt ttgtttgcaa gcagcagatt acgcgcagaa aaaaaggatc tcaagaagat     4200

cctttgatct tttctacggg gtctgacgct cagtggaacg aaaactcacg ttaagggatt     4260

ttggtcatga gattatcaaa aaggatcttc acctagatcc ttttaaatta aaaatgaagt     4320

tttaaatcaa tctaaagtat atatgagtaa acttggtctg acagttacca atgcttaatc     4380

agtgaggcac ctatctcagc gatctgtcta tttcgttcat ccatagttgc ctgactcggg     4440

gggggggggc gctgaggtct gcctcgtgaa gaaggtgttg ctgactcata ccaggcctga     4500

atcgccccat catccagcca gaaagtgagg gagccacggt tgatgagagc tttgttgtag     4560

gtggaccagt tggtgatttt gaacttttgc tttgccacgg aacggtctgc gttgtcggga     4620

agatgcgtga tctgatcctt caactcagca aaagttcgat ttattcaaca aagccgccgt     4680

cccgtcaagt cagcgtaatg ctctgccagt gttacaacca attaaccaat tctgattaga     4740

aaaactcatc gagcatcaaa tgaaactgca atttattcat atcaggatta tcaataccat     4800

atttttgaaa aagccgtttc tgtaatgaag gagaaaactc accgaggcag ttccatagga     4860

tggcaagatc ctggtatcgg tctgcgattc cgactcgtcc aacatcaata caacctatta     4920

atttcccctc gtcaaaaata aggttatcaa gtgagaaatc accatgagtg acgactgaat     4980

ccggtgagaa tggcaaaagc ttatgcattt ctttccagac ttgttcaaca ggccagccat     5040

tacgctcgtc atcaaaatca ctcgcatcaa ccaaaccgtt attcattcgt gattgcgcct     5100

gagcgagacg aaatacgcga tcgctgttaa aaggacaatt acaaacagga atcgaatgca     5160

accggcgcag gaacactgcc agcgcatcaa caatattttc acctgaatca ggatattctt     5220

ctaatacctg gaatgctgtt ttcccgggga tcgcagtggt gagtaaccat gcatcatcag     5280

gagtacggat aaaatgcttg atggtcggaa gaggcataaa ttccgtcagc cagtttagtc     5340

tgaccatctc atctgtaaca tcattggcaa cgctaccttt gccatgtttc agaaacaact     5400

ctggcgcatc gggcttccca tacaatcgat agattgtcgc acctgattgc ccgacattat     5460

cgcgagccca tttataccca tataaatcag catccatgtt ggaatttaat cgcggcctcg     5520

agcaagacgt ttcccgttga atatggctca taacacccct tgtattactg tttatgtaag     5580

cagacagttt tattgttcat gatgatatat ttttatcttg tgcaatgtaa catcagagat     5640

tttgagacac aacgtggctt tccccccccc cccattattg aagcatttat cagggttatt     5700

gtctcatgag cggatacata tttgaatgta tttagaaaaa taaacaaata ggggttccgc     5760

gcacatttcc ccgaaaagtg ccacctgacg tctaagaaac cattattatc atgacattaa     5820

cctataaaaa taggcgtatc acgaggccct ttcgtc                               5856


<210>  61
<211>  5119
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant Antibody Sequence

<400>  61
tcgcgcgttt cggtgatgac ggtgaaaacc tctgacacat gcagctcccg gagacggtca       60

cagcttgtct gtaagcggat gccgggagca gacaagcccg tcagggcgcg tcagcgggtg      120

ttggcgggtg tcggggctgg cttaactatg cggcatcaga gcagattgta ctgagagtgc      180

accatatgcg gtgtgaaata ccgcacagat gcgtaaggag aaaataccgc atcagattgg      240

ctattggcca ttgcatacgt tgtatccata tcataatatg tacatttata ttggctcatg      300

tccaacatta ccgccatgtt gacattgatt attgactagt tattaatagt aatcaattac      360

ggggtcatta gttcatagcc catatatgga gttccgcgtt acataactta cggtaaatgg      420

cccgcctggc tgaccgccca acgacccccg cccattgacg tcaataatga cgtatgttcc      480

catagtaacg ccaataggga ctttccattg acgtcaatgg gtggagtatt tacggtaaac      540

tgcccacttg gcagtacatc aagtgtatca tatgccaagt acgcccccta ttgacgtcaa      600

tgacggtaaa tggcccgcct ggcattatgc ccagtacatg accttatggg actttcctac      660

ttggcagtac atctacgtat tagtcatcgc tattaccatg gtgatgcggt tttggcagta      720

catcaatggg cgtggatagc ggtttgactc acggggattt ccaagtctcc accccattga      780

cgtcaatggg agtttgtttt ggcaccaaaa tcaacgggac tttccaaaat gtcgtaacaa      840

ctccgcccca ttgacgcaaa tgggcggtag gcgtgtacgg tgggaggtct atataagcag      900

agctcgttta gtgaaccgtc agatcgcctg gagacgccat ccacgctgtt ttgacctcca      960

tagaagacac cgggaccgat ccagcctcca tcggctcgca tctctccttc acgcgcccgc     1020

cgccctacct gaggccgcca tccacgccgg ttgagtcgcg ttctgccgcc tcccgcctgt     1080

ggtgcctcct gaactgcgtc cgccgtctag gtaagtttaa agctcaggtc gagaccgggc     1140

ctttgtccgg cgctcccttg gagcctacct agactcagcc ggctctccac gctttgcctg     1200

accctgcttg ctcaactcta gttaacggtg gagggcagtg tagtctgagc agtactcgtt     1260

gctgccgcgc gcgccaccag acataatagc tgacagacta acagactgtt cctttccatg     1320

ggtcttttct gcagtcaccg tcgtcgacac gtgtgatcag atatcgcggc cgctctagac     1380

caccatggga tggtcatgta tcatcctttt tctagtagca actgcaaccg gttctgtgac     1440

cgcatccgaa ctgactcagg accctgccgt ctctgtggca ctgaagcaga ctgtgactat     1500

tacttgccga ggcgactcac tgcggtgcca ctacgcttcc tggtatcaga agaaacccgg     1560

ccaggcacct gtgctgctgt tctacggaaa gaacaatagg ccatctggca tccccgaccg     1620

cttttctggc agtgcatcag ggaaccgagc cagtctgacc attaccggcg cccaggctga     1680

ggacgaagcc gattactatt gcagctcccg ggataagagc ggctccagac tgagcgtgtt     1740

cggaggagga actaaactga ccgtcctcag tcagcccaag gctgccccct cggtcactct     1800

gttcccgccc tcgagtgagg agcttcaagc caacaaggcc acactggtgt gtctcataag     1860

tgacttctac ccgggagccg tgacagtggc ctggaaggca gatagcagcc ccgtcaaggc     1920

gggagtggag accaccacac cctccaaaca aagcaacaac aagtacgcgg ccagcagcta     1980

cctgagcctg acgcctgagc agtggaagtc ccacagaagc tacagctgcc aggtcacgca     2040

tgaagggagc accgtggaga agacagtggc ccctacagaa tgttcataga agctgatcca     2100

gatctgctgt gccttctagt tgccagccat ctgttgtttg cccctccccc gtgccttcct     2160

tgaccctgga aggtgccact cccactgtcc tttcctaata aaatgaggaa attgcatcgc     2220

attgtctgag taggtgtcat tctattctgg ggggtggggt ggggcaggac agcaaggggg     2280

aggattggga agacaatagc aggcatgctg gggatgcggt gggctctatg ggtacccagg     2340

tgctgaagaa ttgacccggt tcctcctggg ccagaaagaa gcaggcacat ccccttctct     2400

gtgacacacc ctgtccacgc ccctggttct tagttccagc cccactcata ggacactcat     2460

agctcaggag ggctccgcct tcaatcccac ccgctaaagt acttggagcg gtctctccct     2520

ccctcatcag cccaccaaac caaacctagc ctccaagagt gggaagaaat taaagcaaga     2580

taggctatta agtgcagagg gagagaaaat gcctccaaca tgtgaggaag taatgagaga     2640

aatcatagaa ttttaaggcc atgatttaag gccatcatgg ccttaatctt ccgcttcctc     2700

gctcactgac tcgctgcgct cggtcgttcg gctgcggcga gcggtatcag ctcactcaaa     2760

ggcggtaata cggttatcca cagaatcagg ggataacgca ggaaagaaca tgtgagcaaa     2820

aggccagcaa aaggccagga accgtaaaaa ggccgcgttg ctggcgtttt tccataggct     2880

ccgcccccct gacgagcatc acaaaaatcg acgctcaagt cagaggtggc gaaacccgac     2940

aggactataa agataccagg cgtttccccc tggaagctcc ctcgtgcgct ctcctgttcc     3000

gaccctgccg cttaccggat acctgtccgc ctttctccct tcgggaagcg tggcgctttc     3060

tcatagctca cgctgtaggt atctcagttc ggtgtaggtc gttcgctcca agctgggctg     3120

tgtgcacgaa ccccccgttc agcccgaccg ctgcgcctta tccggtaact atcgtcttga     3180

gtccaacccg gtaagacacg acttatcgcc actggcagca gccactggta acaggattag     3240

cagagcgagg tatgtaggcg gtgctacaga gttcttgaag tggtggccta actacggcta     3300

cactagaaga acagtatttg gtatctgcgc tctgctgaag ccagttacct tcggaaaaag     3360

agttggtagc tcttgatccg gcaaacaaac caccgctggt agcggtggtt tttttgtttg     3420

caagcagcag attacgcgca gaaaaaaagg atctcaagaa gatcctttga tcttttctac     3480

ggggtctgac gctcagtgga acgaaaactc acgttaaggg attttggtca tgagattatc     3540

aaaaaggatc ttcacctaga tccttttaaa ttaaaaatga agttttaaat caatctaaag     3600

tatatatgag taaacttggt ctgacagtta ccaatgctta atcagtgagg cacctatctc     3660

agcgatctgt ctatttcgtt catccatagt tgcctgactc gggggggggg ggcgctgagg     3720

tctgcctcgt gaagaaggtg ttgctgactc ataccaggcc tgaatcgccc catcatccag     3780

ccagaaagtg agggagccac ggttgatgag agctttgttg taggtggacc agttggtgat     3840

tttgaacttt tgctttgcca cggaacggtc tgcgttgtcg ggaagatgcg tgatctgatc     3900

cttcaactca gcaaaagttc gatttattca acaaagccgc cgtcccgtca agtcagcgta     3960

atgctctgcc agtgttacaa ccaattaacc aattctgatt agaaaaactc atcgagcatc     4020

aaatgaaact gcaatttatt catatcagga ttatcaatac catatttttg aaaaagccgt     4080

ttctgtaatg aaggagaaaa ctcaccgagg cagttccata ggatggcaag atcctggtat     4140

cggtctgcga ttccgactcg tccaacatca atacaaccta ttaatttccc ctcgtcaaaa     4200

ataaggttat caagtgagaa atcaccatga gtgacgactg aatccggtga gaatggcaaa     4260

agcttatgca tttctttcca gacttgttca acaggccagc cattacgctc gtcatcaaaa     4320

tcactcgcat caaccaaacc gttattcatt cgtgattgcg cctgagcgag acgaaatacg     4380

cgatcgctgt taaaaggaca attacaaaca ggaatcgaat gcaaccggcg caggaacact     4440

gccagcgcat caacaatatt ttcacctgaa tcaggatatt cttctaatac ctggaatgct     4500

gttttcccgg ggatcgcagt ggtgagtaac catgcatcat caggagtacg gataaaatgc     4560

ttgatggtcg gaagaggcat aaattccgtc agccagttta gtctgaccat ctcatctgta     4620

acatcattgg caacgctacc tttgccatgt ttcagaaaca actctggcgc atcgggcttc     4680

ccatacaatc gatagattgt cgcacctgat tgcccgacat tatcgcgagc ccatttatac     4740

ccatataaat cagcatccat gttggaattt aatcgcggcc tcgagcaaga cgtttcccgt     4800

tgaatatggc tcataacacc ccttgtatta ctgtttatgt aagcagacag ttttattgtt     4860

catgatgata tatttttatc ttgtgcaatg taacatcaga gattttgaga cacaacgtgg     4920

ctttcccccc ccccccatta ttgaagcatt tatcagggtt attgtctcat gagcggatac     4980

atatttgaat gtatttagaa aaataaacaa ataggggttc cgcgcacatt tccccgaaaa     5040

gtgccacctg acgtctaaga aaccattatt atcatgacat taacctataa aaataggcgt     5100

atcacgaggc cctttcgtc                                                  5119


<210>  62
<211>  5856
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant Antibody Sequence

<400>  62
tcgcgcgttt cggtgatgac ggtgaaaacc tctgacacat gcagctcccg gagacggtca       60

cagcttgtct gtaagcggat gccgggagca gacaagcccg tcagggcgcg tcagcgggtg      120

ttggcgggtg tcggggctgg cttaactatg cggcatcaga gcagattgta ctgagagtgc      180

accatatgcg gtgtgaaata ccgcacagat gcgtaaggag aaaataccgc atcagattgg      240

ctattggcca ttgcatacgt tgtatccata tcataatatg tacatttata ttggctcatg      300

tccaacatta ccgccatgtt gacattgatt attgactagt tattaatagt aatcaattac      360

ggggtcatta gttcatagcc catatatgga gttccgcgtt acataactta cggtaaatgg      420

cccgcctggc tgaccgccca acgacccccg cccattgacg tcaataatga cgtatgttcc      480

catagtaacg ccaataggga ctttccattg acgtcaatgg gtggagtatt tacggtaaac      540

tgcccacttg gcagtacatc aagtgtatca tatgccaagt acgcccccta ttgacgtcaa      600

tgacggtaaa tggcccgcct ggcattatgc ccagtacatg accttatggg actttcctac      660

ttggcagtac atctacgtat tagtcatcgc tattaccatg gtgatgcggt tttggcagta      720

catcaatggg cgtggatagc ggtttgactc acggggattt ccaagtctcc accccattga      780

cgtcaatggg agtttgtttt ggcaccaaaa tcaacgggac tttccaaaat gtcgtaacaa      840

ctccgcccca ttgacgcaaa tgggcggtag gcgtgtacgg tgggaggtct atataagcag      900

agctcgttta gtgaaccgtc agatcgcctg gagacgccat ccacgctgtt ttgacctcca      960

tagaagacac cgggaccgat ccagcctcca tcggctcgca tctctccttc acgcgcccgc     1020

cgccctacct gaggccgcca tccacgccgg ttgagtcgcg ttctgccgcc tcccgcctgt     1080

ggtgcctcct gaactgcgtc cgccgtctag gtaagtttaa agctcaggtc gagaccgggc     1140

ctttgtccgg cgctcccttg gagcctacct agactcagcc ggctctccac gctttgcctg     1200

accctgcttg ctcaactcta gttaacggtg gagggcagtg tagtctgagc agtactcgtt     1260

gctgccgcgc gcgccaccag acataatagc tgacagacta acagactgtt cctttccatg     1320

ggtcttttct gcagtcaccg tcgtcgacac gtgtgatcag atatcgcggc cgctctagac     1380

caccatgggc tggtcctgta ttatcctgtt cctggtcgca actgctactg gcgtccattc     1440

agaagtgagg ctggtcgaga gcggcggcgg cctggtgaag ccaggaggaa gcctgcgact     1500

gagctgctcc gcctctggct tcgactttga taacgcttgg atgacatggg tgcgacagcc     1560

ccctggaaaa ggcctggagt gggtcggaag aatcaccggc cccggagagg gatggagtgt     1620

ggactacgca gaatcagtca agggccggtt caccattagc cgggataaca ccaaaaatac     1680

actgtatctg gagatgaaca atgtcaggac tgaagacacc gggtactatt tctgtgcccg     1740

caccggaaag tactatgatt tttggtgggg ctacccaccc ggagaagaat actttcagga     1800

ctggggacag ggaacactgg tcatcgtcag cagcgcctcg accaagggcc catcggtctt     1860

ccccctggca ccctcctcca agagcacctc tgggggcaca gcggccctgg gctgcctggt     1920

caaggactac ttccccgaac cggtgacggt gtcgtggaac tcaggcgccc tgaccagcgg     1980

cgtgcacacc ttcccggctg tcctacagtc ctcaggactc tactccctca gcagcgtggt     2040

gaccgtgccc tccagcagct tgggcaccca gacctacatc tgcaacgtga atcacaagcc     2100

cagcaacacc aaggtggaca agaaagttga gcccaaatct tgtgacaaaa ctcacacatg     2160

cccaccgtgc ccagcacctg aactcctggg gggaccgtca gtcttcctct tccccccaaa     2220

acccaaggac accctcatga tctcccggac ccctgaggtc acatgcgtgg tggtggacgt     2280

gagccacgaa gaccctgagg tcaagttcaa ctggtacgtg gacggcgtgg aggtgcataa     2340

tgccaagaca aagccgcggg aggagcagta caacagcacg taccgtgtgg tcagcgtcct     2400

caccgtcctg caccaggact ggctgaatgg caaggagtac aagtgcaagg tctccaacaa     2460

agccctccca gcccccatcg agaaaaccat ctccaaagcc aaagggcagc cccgagaacc     2520

acaggtgtac accctgcccc catcccggga tgagctgacc aagaaccagg tcagcctgac     2580

ctgcctggtc aaaggcttct atcccagcga catcgccgtg gagtgggaga gcaatgggca     2640

gccggagaac aactacaaga ccacgcctcc cgtgctggac tccgacggct ccttcttcct     2700

ctacagcaag ctcaccgtgg acaagagcag gtggcagcag gggaacgtct tctcatgctc     2760

cgtgatgcat gaggctctgc acaaccacta cacgcagaag agcctctccc tgtctccggg     2820

taaatgatga ggatccagat ctgctgtgcc ttctagttgc cagccatctg ttgtttgccc     2880

ctcccccgtg ccttccttga ccctggaagg tgccactccc actgtccttt cctaataaaa     2940

tgaggaaatt gcatcgcatt gtctgagtag gtgtcattct attctggggg gtggggtggg     3000

gcaggacagc aagggggagg attgggaaga caatagcagg catgctgggg atgcggtggg     3060

ctctatgggt acccaggtgc tgaagaattg acccggttcc tcctgggcca gaaagaagca     3120

ggcacatccc cttctctgtg acacaccctg tccacgcccc tggttcttag ttccagcccc     3180

actcatagga cactcatagc tcaggagggc tccgccttca atcccacccg ctaaagtact     3240

tggagcggtc tctccctccc tcatcagccc accaaaccaa acctagcctc caagagtggg     3300

aagaaattaa agcaagatag gctattaagt gcagagggag agaaaatgcc tccaacatgt     3360

gaggaagtaa tgagagaaat catagaattt taaggccatg atttaaggcc atcatggcct     3420

taatcttccg cttcctcgct cactgactcg ctgcgctcgg tcgttcggct gcggcgagcg     3480

gtatcagctc actcaaaggc ggtaatacgg ttatccacag aatcagggga taacgcagga     3540

aagaacatgt gagcaaaagg ccagcaaaag gccaggaacc gtaaaaaggc cgcgttgctg     3600

gcgtttttcc ataggctccg cccccctgac gagcatcaca aaaatcgacg ctcaagtcag     3660

aggtggcgaa acccgacagg actataaaga taccaggcgt ttccccctgg aagctccctc     3720

gtgcgctctc ctgttccgac cctgccgctt accggatacc tgtccgcctt tctcccttcg     3780

ggaagcgtgg cgctttctca tagctcacgc tgtaggtatc tcagttcggt gtaggtcgtt     3840

cgctccaagc tgggctgtgt gcacgaaccc cccgttcagc ccgaccgctg cgccttatcc     3900

ggtaactatc gtcttgagtc caacccggta agacacgact tatcgccact ggcagcagcc     3960

actggtaaca ggattagcag agcgaggtat gtaggcggtg ctacagagtt cttgaagtgg     4020

tggcctaact acggctacac tagaagaaca gtatttggta tctgcgctct gctgaagcca     4080

gttaccttcg gaaaaagagt tggtagctct tgatccggca aacaaaccac cgctggtagc     4140

ggtggttttt ttgtttgcaa gcagcagatt acgcgcagaa aaaaaggatc tcaagaagat     4200

cctttgatct tttctacggg gtctgacgct cagtggaacg aaaactcacg ttaagggatt     4260

ttggtcatga gattatcaaa aaggatcttc acctagatcc ttttaaatta aaaatgaagt     4320

tttaaatcaa tctaaagtat atatgagtaa acttggtctg acagttacca atgcttaatc     4380

agtgaggcac ctatctcagc gatctgtcta tttcgttcat ccatagttgc ctgactcggg     4440

gggggggggc gctgaggtct gcctcgtgaa gaaggtgttg ctgactcata ccaggcctga     4500

atcgccccat catccagcca gaaagtgagg gagccacggt tgatgagagc tttgttgtag     4560

gtggaccagt tggtgatttt gaacttttgc tttgccacgg aacggtctgc gttgtcggga     4620

agatgcgtga tctgatcctt caactcagca aaagttcgat ttattcaaca aagccgccgt     4680

cccgtcaagt cagcgtaatg ctctgccagt gttacaacca attaaccaat tctgattaga     4740

aaaactcatc gagcatcaaa tgaaactgca atttattcat atcaggatta tcaataccat     4800

atttttgaaa aagccgtttc tgtaatgaag gagaaaactc accgaggcag ttccatagga     4860

tggcaagatc ctggtatcgg tctgcgattc cgactcgtcc aacatcaata caacctatta     4920

atttcccctc gtcaaaaata aggttatcaa gtgagaaatc accatgagtg acgactgaat     4980

ccggtgagaa tggcaaaagc ttatgcattt ctttccagac ttgttcaaca ggccagccat     5040

tacgctcgtc atcaaaatca ctcgcatcaa ccaaaccgtt attcattcgt gattgcgcct     5100

gagcgagacg aaatacgcga tcgctgttaa aaggacaatt acaaacagga atcgaatgca     5160

accggcgcag gaacactgcc agcgcatcaa caatattttc acctgaatca ggatattctt     5220

ctaatacctg gaatgctgtt ttcccgggga tcgcagtggt gagtaaccat gcatcatcag     5280

gagtacggat aaaatgcttg atggtcggaa gaggcataaa ttccgtcagc cagtttagtc     5340

tgaccatctc atctgtaaca tcattggcaa cgctaccttt gccatgtttc agaaacaact     5400

ctggcgcatc gggcttccca tacaatcgat agattgtcgc acctgattgc ccgacattat     5460

cgcgagccca tttataccca tataaatcag catccatgtt ggaatttaat cgcggcctcg     5520

agcaagacgt ttcccgttga atatggctca taacacccct tgtattactg tttatgtaag     5580

cagacagttt tattgttcat gatgatatat ttttatcttg tgcaatgtaa catcagagat     5640

tttgagacac aacgtggctt tccccccccc cccattattg aagcatttat cagggttatt     5700

gtctcatgag cggatacata tttgaatgta tttagaaaaa taaacaaata ggggttccgc     5760

gcacatttcc ccgaaaagtg ccacctgacg tctaagaaac cattattatc atgacattaa     5820

cctataaaaa taggcgtatc acgaggccct ttcgtc                               5856


<210>  63
<211>  5856
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant Antibody Sequence

<400>  63
tcgcgcgttt cggtgatgac ggtgaaaacc tctgacacat gcagctcccg gagacggtca       60

cagcttgtct gtaagcggat gccgggagca gacaagcccg tcagggcgcg tcagcgggtg      120

ttggcgggtg tcggggctgg cttaactatg cggcatcaga gcagattgta ctgagagtgc      180

accatatgcg gtgtgaaata ccgcacagat gcgtaaggag aaaataccgc atcagattgg      240

ctattggcca ttgcatacgt tgtatccata tcataatatg tacatttata ttggctcatg      300

tccaacatta ccgccatgtt gacattgatt attgactagt tattaatagt aatcaattac      360

ggggtcatta gttcatagcc catatatgga gttccgcgtt acataactta cggtaaatgg      420

cccgcctggc tgaccgccca acgacccccg cccattgacg tcaataatga cgtatgttcc      480

catagtaacg ccaataggga ctttccattg acgtcaatgg gtggagtatt tacggtaaac      540

tgcccacttg gcagtacatc aagtgtatca tatgccaagt acgcccccta ttgacgtcaa      600

tgacggtaaa tggcccgcct ggcattatgc ccagtacatg accttatggg actttcctac      660

ttggcagtac atctacgtat tagtcatcgc tattaccatg gtgatgcggt tttggcagta      720

catcaatggg cgtggatagc ggtttgactc acggggattt ccaagtctcc accccattga      780

cgtcaatggg agtttgtttt ggcaccaaaa tcaacgggac tttccaaaat gtcgtaacaa      840

ctccgcccca ttgacgcaaa tgggcggtag gcgtgtacgg tgggaggtct atataagcag      900

agctcgttta gtgaaccgtc agatcgcctg gagacgccat ccacgctgtt ttgacctcca      960

tagaagacac cgggaccgat ccagcctcca tcggctcgca tctctccttc acgcgcccgc     1020

cgccctacct gaggccgcca tccacgccgg ttgagtcgcg ttctgccgcc tcccgcctgt     1080

ggtgcctcct gaactgcgtc cgccgtctag gtaagtttaa agctcaggtc gagaccgggc     1140

ctttgtccgg cgctcccttg gagcctacct agactcagcc ggctctccac gctttgcctg     1200

accctgcttg ctcaactcta gttaacggtg gagggcagtg tagtctgagc agtactcgtt     1260

gctgccgcgc gcgccaccag acataatagc tgacagacta acagactgtt cctttccatg     1320

ggtcttttct gcagtcaccg tcgtcgacac gtgtgatcag atatcgcggc cgctctagac     1380

caccatggga tggtcatgta tcatcctttt tctagtagca actgcaaccg gtgtacattc     1440

tgaggttaga ctggtggagt caggaggggg gcttgtgaag cccggtgggt ctctccgcct     1500

gagctgttct gcctccggct ttgatttcga taacgcctgg atgacctggg tcaggcagcc     1560

tccaggtaag ggactggagt gggtgggaag aatcacaggt ccaggcgagg gctggtccgt     1620

ggactacgcg gaatctgtta aagggcggtt tacaatctca agggacaata ccaagaatac     1680

cttgtatttg gagatgaaca acgtgagaac tgaagacacc ggatattact tctgtgccag     1740

aacaggcaaa tactacgact tctggtgggg ctgcccccct ggcgaggaat attttcaaga     1800

ctggggtcag ggaacccttg ttatcgtgtc ctccgcgtcg accaagggcc catcggtctt     1860

ccccctggca ccctcctcca agagcacctc tgggggcaca gcggccctgg gctgcctggt     1920

caaggactac ttccccgaac cggtgacggt gtcgtggaac tcaggcgccc tgaccagcgg     1980

cgtgcacacc ttcccggctg tcctacagtc ctcaggactc tactccctca gcagcgtggt     2040

gaccgtgccc tccagcagct tgggcaccca gacctacatc tgcaacgtga atcacaagcc     2100

cagcaacacc aaggtggaca agaaagttga gcccaaatct tgtgacaaaa ctcacacatg     2160

cccaccgtgc ccagcacctg aactcctggg gggaccgtca gtcttcctct tccccccaaa     2220

acccaaggac accctcatga tctcccggac ccctgaggtc acatgcgtgg tggtggacgt     2280

gagccacgaa gaccctgagg tcaagttcaa ctggtacgtg gacggcgtgg aggtgcataa     2340

tgccaagaca aagccgcggg aggagcagta caacagcacg taccgtgtgg tcagcgtcct     2400

caccgtcctg caccaggact ggctgaatgg caaggagtac aagtgcaagg tctccaacaa     2460

agccctccca gcccccatcg agaaaaccat ctccaaagcc aaagggcagc cccgagaacc     2520

acaggtgtac accctgcccc catcccggga tgagctgacc aagaaccagg tcagcctgac     2580

ctgcctggtc aaaggcttct atcccagcga catcgccgtg gagtgggaga gcaatgggca     2640

gccggagaac aactacaaga ccacgcctcc cgtgctggac tccgacggct ccttcttcct     2700

ctacagcaag ctcaccgtgg acaagagcag gtggcagcag gggaacgtct tctcatgctc     2760

cgtgatgcat gaggctctgc acaaccacta cacgcagaag agcctctccc tgtctccggg     2820

taaatgatga ggatccagat ctgctgtgcc ttctagttgc cagccatctg ttgtttgccc     2880

ctcccccgtg ccttccttga ccctggaagg tgccactccc actgtccttt cctaataaaa     2940

tgaggaaatt gcatcgcatt gtctgagtag gtgtcattct attctggggg gtggggtggg     3000

gcaggacagc aagggggagg attgggaaga caatagcagg catgctgggg atgcggtggg     3060

ctctatgggt acccaggtgc tgaagaattg acccggttcc tcctgggcca gaaagaagca     3120

ggcacatccc cttctctgtg acacaccctg tccacgcccc tggttcttag ttccagcccc     3180

actcatagga cactcatagc tcaggagggc tccgccttca atcccacccg ctaaagtact     3240

tggagcggtc tctccctccc tcatcagccc accaaaccaa acctagcctc caagagtggg     3300

aagaaattaa agcaagatag gctattaagt gcagagggag agaaaatgcc tccaacatgt     3360

gaggaagtaa tgagagaaat catagaattt taaggccatg atttaaggcc atcatggcct     3420

taatcttccg cttcctcgct cactgactcg ctgcgctcgg tcgttcggct gcggcgagcg     3480

gtatcagctc actcaaaggc ggtaatacgg ttatccacag aatcagggga taacgcagga     3540

aagaacatgt gagcaaaagg ccagcaaaag gccaggaacc gtaaaaaggc cgcgttgctg     3600

gcgtttttcc ataggctccg cccccctgac gagcatcaca aaaatcgacg ctcaagtcag     3660

aggtggcgaa acccgacagg actataaaga taccaggcgt ttccccctgg aagctccctc     3720

gtgcgctctc ctgttccgac cctgccgctt accggatacc tgtccgcctt tctcccttcg     3780

ggaagcgtgg cgctttctca tagctcacgc tgtaggtatc tcagttcggt gtaggtcgtt     3840

cgctccaagc tgggctgtgt gcacgaaccc cccgttcagc ccgaccgctg cgccttatcc     3900

ggtaactatc gtcttgagtc caacccggta agacacgact tatcgccact ggcagcagcc     3960

actggtaaca ggattagcag agcgaggtat gtaggcggtg ctacagagtt cttgaagtgg     4020

tggcctaact acggctacac tagaagaaca gtatttggta tctgcgctct gctgaagcca     4080

gttaccttcg gaaaaagagt tggtagctct tgatccggca aacaaaccac cgctggtagc     4140

ggtggttttt ttgtttgcaa gcagcagatt acgcgcagaa aaaaaggatc tcaagaagat     4200

cctttgatct tttctacggg gtctgacgct cagtggaacg aaaactcacg ttaagggatt     4260

ttggtcatga gattatcaaa aaggatcttc acctagatcc ttttaaatta aaaatgaagt     4320

tttaaatcaa tctaaagtat atatgagtaa acttggtctg acagttacca atgcttaatc     4380

agtgaggcac ctatctcagc gatctgtcta tttcgttcat ccatagttgc ctgactcggg     4440

gggggggggc gctgaggtct gcctcgtgaa gaaggtgttg ctgactcata ccaggcctga     4500

atcgccccat catccagcca gaaagtgagg gagccacggt tgatgagagc tttgttgtag     4560

gtggaccagt tggtgatttt gaacttttgc tttgccacgg aacggtctgc gttgtcggga     4620

agatgcgtga tctgatcctt caactcagca aaagttcgat ttattcaaca aagccgccgt     4680

cccgtcaagt cagcgtaatg ctctgccagt gttacaacca attaaccaat tctgattaga     4740

aaaactcatc gagcatcaaa tgaaactgca atttattcat atcaggatta tcaataccat     4800

atttttgaaa aagccgtttc tgtaatgaag gagaaaactc accgaggcag ttccatagga     4860

tggcaagatc ctggtatcgg tctgcgattc cgactcgtcc aacatcaata caacctatta     4920

atttcccctc gtcaaaaata aggttatcaa gtgagaaatc accatgagtg acgactgaat     4980

ccggtgagaa tggcaaaagc ttatgcattt ctttccagac ttgttcaaca ggccagccat     5040

tacgctcgtc atcaaaatca ctcgcatcaa ccaaaccgtt attcattcgt gattgcgcct     5100

gagcgagacg aaatacgcga tcgctgttaa aaggacaatt acaaacagga atcgaatgca     5160

accggcgcag gaacactgcc agcgcatcaa caatattttc acctgaatca ggatattctt     5220

ctaatacctg gaatgctgtt ttcccgggga tcgcagtggt gagtaaccat gcatcatcag     5280

gagtacggat aaaatgcttg atggtcggaa gaggcataaa ttccgtcagc cagtttagtc     5340

tgaccatctc atctgtaaca tcattggcaa cgctaccttt gccatgtttc agaaacaact     5400

ctggcgcatc gggcttccca tacaatcgat agattgtcgc acctgattgc ccgacattat     5460

cgcgagccca tttataccca tataaatcag catccatgtt ggaatttaat cgcggcctcg     5520

agcaagacgt ttcccgttga atatggctca taacacccct tgtattactg tttatgtaag     5580

cagacagttt tattgttcat gatgatatat ttttatcttg tgcaatgtaa catcagagat     5640

tttgagacac aacgtggctt tccccccccc cccattattg aagcatttat cagggttatt     5700

gtctcatgag cggatacata tttgaatgta tttagaaaaa taaacaaata ggggttccgc     5760

gcacatttcc ccgaaaagtg ccacctgacg tctaagaaac cattattatc atgacattaa     5820

cctataaaaa taggcgtatc acgaggccct ttcgtc                               5856


<210>  64
<211>  450
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant Antibody Sequence

<400>  64
atgggctggt cctgtattat cctgttcctg gtcgcaactg ctactggcgt ccattcagaa       60

gtgaggctgg tcgagagcgg cggcggcctg gtgaagccag gaggaagcct gcgactgagc      120

tgctccgcct ctggcttcga ctttgataac gcttggatga catgggtgcg acagccccct      180

ggaaaaggcc tggagtgggt cggaagaatc accggccccg gagagggatg gagtgtggac      240

tacgcagaat cagtcaaggg ccggttcacc attagccggg ataacaccaa aaatacactg      300

tatctggaga tgaacaatgt caggactgaa gacaccgggt actatttctg tgcccgcacc      360

ggaaagtact atgatttttg gtggggctac ccacccggag aagaatactt tcaggactgg      420

ggacagggaa cactggtcat cgtcagcagc                                       450


<210>  65
<211>  450
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant Antibody Sequence

<400>  65
atgggatggt catgtatcat cctttttcta gtagcaactg caaccggtgt acattctgag       60

gttagactgg tggagtcagg aggggggctt gtgaagcccg gtgggtctct ccgcctgagc      120

tgttctgcct ccggctttga tttcgataac gcctggatga cctgggtcag gcagcctcca      180

ggtaagggac tggagtgggt gggaagaatc acaggtccag gcgagggctg gtccgtggac      240

tacgcggaat ctgttaaagg gcggtttaca atctcaaggg acaataccaa gaataccttg      300

tatttggaga tgaacaacgt gagaactgaa gacaccggat attacttctg tgccagaaca      360

ggcaaatact acgacttctg gtccggctgc ccccctggcg aggaatattt tcaagactgg      420

ggtcagggaa cccttgttat cgtgtcctcc                                       450


<210>  66
<211>  450
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant Antibody Sequence

<400>  66
atgggatggt catgtatcat cctttttcta gtagcaactg caaccggtgt acattctgag       60

gttagactgg tggagtcagg aggggggctt gtgaagcccg gtgggtctct ccgcctgagc      120

tgttctgcct ccggctttga tttcgataac gcctggatga cctgggtcag gcagcctcca      180

ggtaagggac tggagtgggt gggaagaatc acaggtccag gcgagggctg gtccgtggac      240

tacgcggaat ctgttaaagg gcggtttaca atctcaaggg acaataccaa gaataccttg      300

tatttggaga tgaacaacgt gagaactgaa gacaccggat attacttctg tgccagaaca      360

ggcaaatact acgacttctg gtggggctgc ccccctggcg aggaatattt tcaagactgg      420

ggtcagggaa cccttgttat cgtgtcctcc                                       450


<210>  67
<211>  393
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant Antibody Sequence

<400>  67
gaagtgcggc tggctgagag cggcgggggg ctggtcaaac ctggcgggtc actgcggctg       60

tcctgttctg cctccggctt cgattttgat aacgcatgga tgacatgggt gcgacagcca      120

cctggaaagg ggctggagtg ggtcggcaga atcactggac ctggcgaagg gtggtctgtg      180

gactacgcag ctccagtcga gggacgattc accattagta gagataacta caagaataca      240

ctgtatctgg agatgaacaa tctgaggact gaagacagcg gcctgtattt ctgcgcccgc      300

accgggaaat actatgattt ttggtggggg tacccacccg gagaggaata ttttcaggac      360

tggggacggg gcaccctggt gatcgtcagc tcc                                   393


<210>  68
<211>  393
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant Antibody Sequence

<400>  68
gaagtgcggc tggctgagag cggcgggggg ctggtcaaac ctggcgggtc actgcggctg       60

tcctgttctg cctccggctt cgattttgat aacgcatgga tgacatgggt gcgacagcca      120

cctggaaagg ggctggagtg ggtcggcaga atcactggac ctggcgaagg gtggtctgtg      180

gactacgcag ctccagtcga gggacgattc accattagta gagataacta caagaataca      240

ctgtatctgg agatgaacaa tctgaggact gaagacagcg gcctgtattt ctgcgcccgc      300

accgggaaat actatgattt ttggtctggg tgcccacccg gagaggaata ttttcaggac      360

tggggacggg gcaccctggt gatcgtcagc tcc                                   393


<210>  69
<211>  393
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant Antibody Sequence

<400>  69
gaagtgcggc tggctgagag cggcgggggg ctggtcaaac ctggcgggtc actgcggctg       60

tcctgttctg cctccggctt cgattttgat aacgcatgga tgacatgggt gcgacagcca      120

cctggaaagg ggctggagtg ggtcggcaga atcactggac ctggcgaagg gtggtctgtg      180

gactacgcag ctccagtcga gggacgattc accattagta gagataacta caagaataca      240

ctgtatctgg agatgaacaa tctgaggact gaagacagcg gcctgtattt ctgcgcccgc      300

accgggaaat actatgattt ttggtggggg tgcccacccg gagaggaata ttttcaggac      360

tggggacggg gcaccctggt gatcgtcagc tcc                                   393


<210>  70
<211>  384
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant Antibody Sequence

<400>  70
atgggatggt catgtatcat cctttttcta gtagcaactg caaccggttc tgtgaccgca       60

tccgaactga ctcaggaccc tgccgtctct gtggcactga agcagactgt gactattact      120

tgccgaggcg actcactgcg gtgccactac gcttcctggt atcagaagaa acccggccag      180

gcacctgtgc tgctgttcta cggaaagaac aataggccat ctggcatccc cgaccgcttt      240

tctggcagtg catcagggaa ccgagccagt ctgaccatta ccggcgccca ggctgaggac      300

gaagccgatt actattgcag ctcccgggat aagagcggct ccagactgag cgtgttcgga      360

ggaggaacta aactgaccgt cctc                                             384


<210>  71
<211>  384
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant Antibody Sequence

<400>  71
atgggatggt catgtatcat cctttttcta gtagcaactg caaccggttc tgtgaccgca       60

tccgaactga ctcaggaccc tgccgtctct gtggcactga agcagactgt gactattact      120

tgccgaggcg actcactgcg gagccactgg gcttcctggt atcagaagaa acccggccag      180

gcacctgtgc tgctgttcta cggaaagaac aataggccat ctggcatccc cgaccgcttt      240

tctggcagtg catcagggaa ccgagccagt ctgaccatta ccggcgccca ggctgaggac      300

gaagccgatt actattgcag ctcccgggat aagagcggct ccagactgag cgtgttcgga      360

ggaggaacta aactgaccgt cctc                                             384


<210>  72
<211>  384
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant Antibody Sequence

<400>  72
atgggatggt catgtatcat cctttttcta gtagcaactg caaccggttc tgtgaccgca       60

tccgaactga ctcaggaccc tgccgtctct gtggcactga agcagactgt gactattact      120

tgccgaggcg actcactgcg gagccacttt gcttcctggt atcagaagaa acccggccag      180

gcacctgtgc tgctgttcta cggaaagaac aataggccat ctggcatccc cgaccgcttt      240

tctggcagtg catcagggaa ccgagccagt ctgaccatta ccggcgccca ggctgaggac      300

gaagccgatt actattgcag ctcccgggat aagagcggct ccagactgag cgtgttcgga      360

ggaggaacta aactgaccgt cctc                                             384


<210>  73
<211>  384
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant Antibody Sequence

<400>  73
atgggatggt catgtatcat cctttttcta gtagcaactg caaccggttc tgtgaccgca       60

tccgaactga ctcaggaccc tgccgtctct gtggcactga agcagactgt gactattact      120

tgccgaggcg actcactgcg gagccactgg gcttcctggt atcagaagaa acccggccag      180

gcacctgtgc tgctgttcta cggaaagaac aataggccat ctggcatccc cgaccgcttt      240

tctggcagtg catcagggaa ccgagccagt ctgaccatta ccggcgccca ggctgaggac      300

gaagccgatt actattgcag ctcccgggat aagagcggct ccagactgag cgtgttcgga      360

ggaggaacta aactgaccgt cctc                                             384


<210>  74
<211>  384
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant Antibody Sequence

<400>  74
atgggatggt catgtatcat cctttttcta gtagcaactg caaccggttc tgtgaccgca       60

tccgaactga ctcaggaccc tgccgtctct gtggcactga agcagactgt gactattact      120

tgccgaggcg actcactgcg gagccacttt gcttcctggt atcagaagaa acccggccag      180

gcacctgtgc tgctgttcta cggaaagaac aataggccat ctggcatccc cgaccgcttt      240

tctggcagtg catcagggaa ccgagccagt ctgaccatta ccggcgccca ggctgaggac      300

gaagccgatt actattgcag ctcccgggat aagagcggct ccagactgag cgtgttcgga      360

ggaggaacta aactgaccgt cctc                                             384


<210>  75
<211>  131
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant Antibody Sequence

<400>  75

Glu Val Arg Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Phe Asp Phe Asp Asn Ala 
            20                  25                  30          


Trp Met Thr Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Thr Gly Pro Gly Glu Gly Trp Ser Val Asp Tyr Ala Glu 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Thr Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Glu Met Asn Asn Val Arg Thr Glu Asp Thr Gly Tyr Tyr 
                85                  90                  95      


Phe Cys Ala Arg Thr Gly Lys Tyr Tyr Asp Phe Trp Phe Gly Tyr Pro 
            100                 105                 110         


Pro Gly Glu Glu Tyr Phe Gln Asp Trp Gly Gln Gly Thr Leu Val Ile 
        115                 120                 125             


Val Ser Ser 
    130     


<210>  76
<211>  131
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant Antibody Sequence

<400>  76

Glu Val Arg Leu Arg Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Phe Asp Phe Asp Asn Ala 
            20                  25                  30          


Trp Met Thr Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Thr Gly Pro Gly Glu Gly Trp Ser Val Asp Tyr Ala Glu 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Thr Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Glu Met Asn Asn Val Arg Thr Glu Asp Thr Gly Tyr Tyr 
                85                  90                  95      


Phe Cys Ala Arg Thr Gly Lys Tyr Tyr Asp Phe Trp Phe Gly Tyr Pro 
            100                 105                 110         


Pro Gly Glu Glu Tyr Phe Gln Asp Trp Gly Gln Gly Thr Leu Val Ile 
        115                 120                 125             


Val Ser Ser 
    130     


<210>  77
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant Antibody Sequence

<400>  77

Ala Arg Thr Gly Lys Tyr Tyr Asp Phe Trp Phe Gly Tyr Pro Pro Gly 
1               5                   10                  15      


Glu Glu Tyr Phe Gln Asp 
            20          


<210>  78
<211>  393
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant Antibody Sequence

<400>  78
gaggttagac tggtggagtc aggagggggg cttgtgaagc ccggtgggtc tctccgcctg       60

agctgttctg cctccggctt tgatttcgat aacgcctgga tgacctgggt caggcagcct      120

ccaggtaagg gactggagtg ggtgggaaga atcacaggtc caggcgaggg ctggtccgtg      180

gactacgcgg aatctgttaa agggcggttt acaatctcaa gggacaatac caagaatacc      240

ttgtatttgg agatgaacaa cgtgagaact gaagacaccg gatattactt ctgtgccaga      300

acaggcaaat actacgactt ctggttcggc tatccccctg gcgaggaata ttttcaagac      360

tggggtcagg gaacccttgt tatcgtgtcc tcc                                   393


<210>  79
<211>  393
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant Antibody Sequence

<400>  79
gaggttagac tgcgggagtc aggagggggg cttgtgaagc ccggtgggtc tctccgcctg       60

agctgttctg cctccggctt tgatttcgat aacgcctgga tgacctgggt caggcagcct      120

ccaggtaagg gactggagtg ggtgggaaga atcacaggtc caggcgaggg ctggtccgtg      180

gactacgcgg aatctgttaa agggcggttt acaatctcaa gggacaatac caagaatacc      240

ttgtatttgg agatgaacaa cgtgagaact gaagacaccg gatattactt ctgtgccaga      300

acaggcaaat actacgactt ctggttcggc tatccccctg gcgaggaata ttttcaagac      360

tggggtcagg gaacccttgt tatcgtgtcc tcc                                   393


<210>  80
<211>  5856
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant Antibody Sequence

<400>  80
tcgcgcgttt cggtgatgac ggtgaaaacc tctgacacat gcagctcccg gagacggtca       60

cagcttgtct gtaagcggat gccgggagca gacaagcccg tcagggcgcg tcagcgggtg      120

ttggcgggtg tcggggctgg cttaactatg cggcatcaga gcagattgta ctgagagtgc      180

accatatgcg gtgtgaaata ccgcacagat gcgtaaggag aaaataccgc atcagattgg      240

ctattggcca ttgcatacgt tgtatccata tcataatatg tacatttata ttggctcatg      300

tccaacatta ccgccatgtt gacattgatt attgactagt tattaatagt aatcaattac      360

ggggtcatta gttcatagcc catatatgga gttccgcgtt acataactta cggtaaatgg      420

cccgcctggc tgaccgccca acgacccccg cccattgacg tcaataatga cgtatgttcc      480

catagtaacg ccaataggga ctttccattg acgtcaatgg gtggagtatt tacggtaaac      540

tgcccacttg gcagtacatc aagtgtatca tatgccaagt acgcccccta ttgacgtcaa      600

tgacggtaaa tggcccgcct ggcattatgc ccagtacatg accttatggg actttcctac      660

ttggcagtac atctacgtat tagtcatcgc tattaccatg gtgatgcggt tttggcagta      720

catcaatggg cgtggatagc ggtttgactc acggggattt ccaagtctcc accccattga      780

cgtcaatggg agtttgtttt ggcaccaaaa tcaacgggac tttccaaaat gtcgtaacaa      840

ctccgcccca ttgacgcaaa tgggcggtag gcgtgtacgg tgggaggtct atataagcag      900

agctcgttta gtgaaccgtc agatcgcctg gagacgccat ccacgctgtt ttgacctcca      960

tagaagacac cgggaccgat ccagcctcca tcggctcgca tctctccttc acgcgcccgc     1020

cgccctacct gaggccgcca tccacgccgg ttgagtcgcg ttctgccgcc tcccgcctgt     1080

ggtgcctcct gaactgcgtc cgccgtctag gtaagtttaa agctcaggtc gagaccgggc     1140

ctttgtccgg cgctcccttg gagcctacct agactcagcc ggctctccac gctttgcctg     1200

accctgcttg ctcaactcta gttaacggtg gagggcagtg tagtctgagc agtactcgtt     1260

gctgccgcgc gcgccaccag acataatagc tgacagacta acagactgtt cctttccatg     1320

ggtcttttct gcagtcaccg tcgtcgacac gtgtgatcag atatcgcggc cgctctagac     1380

caccatggga tggtcatgta tcatcctttt tctagtagca actgcaaccg gtgtacattc     1440

tgaggttaga ctggtggagt caggaggggg gcttgtgaag cccggtgggt ctctccgcct     1500

gagctgttct gcctccggct ttgatttcga taacgcctgg atgacctggg tcaggcagcc     1560

tccaggtaag ggactggagt gggtgggaag aatcacaggt ccaggcgagg gctggtccgt     1620

ggactacgcg gaatctgtta aagggcggtt tacaatctca agggacaata ccaagaatac     1680

cttgtatttg gagatgaaca acgtgagaac tgaagacacc ggatattact tctgtgccag     1740

aacaggcaaa tactacgact tctggttcgg ctatccccct ggcgaggaat attttcaaga     1800

ctggggtcag ggaacccttg ttatcgtgtc ctccgcgtcg accaagggcc catcggtctt     1860

ccccctggca ccctcctcca agagcacctc tgggggcaca gcggccctgg gctgcctggt     1920

caaggactac ttccccgaac cggtgacggt gtcgtggaac tcaggcgccc tgaccagcgg     1980

cgtgcacacc ttcccggctg tcctacagtc ctcaggactc tactccctca gcagcgtggt     2040

gaccgtgccc tccagcagct tgggcaccca gacctacatc tgcaacgtga atcacaagcc     2100

cagcaacacc aaggtggaca agaaagttga gcccaaatct tgtgacaaaa ctcacacatg     2160

cccaccgtgc ccagcacctg aactcctggg gggaccgtca gtcttcctct tccccccaaa     2220

acccaaggac accctcatga tctcccggac ccctgaggtc acatgcgtgg tggtggacgt     2280

gagccacgaa gaccctgagg tcaagttcaa ctggtacgtg gacggcgtgg aggtgcataa     2340

tgccaagaca aagccgcggg aggagcagta caacagcacg taccgtgtgg tcagcgtcct     2400

caccgtcctg caccaggact ggctgaatgg caaggagtac aagtgcaagg tctccaacaa     2460

agccctccca gcccccatcg agaaaaccat ctccaaagcc aaagggcagc cccgagaacc     2520

acaggtgtac accctgcccc catcccggga tgagctgacc aagaaccagg tcagcctgac     2580

ctgcctggtc aaaggcttct atcccagcga catcgccgtg gagtgggaga gcaatgggca     2640

gccggagaac aactacaaga ccacgcctcc cgtgctggac tccgacggct ccttcttcct     2700

ctacagcaag ctcaccgtgg acaagagcag gtggcagcag gggaacgtct tctcatgctc     2760

cgtgatgcat gaggctctgc acaaccacta cacgcagaag agcctctccc tgtctccggg     2820

taaatgatga ggatccagat ctgctgtgcc ttctagttgc cagccatctg ttgtttgccc     2880

ctcccccgtg ccttccttga ccctggaagg tgccactccc actgtccttt cctaataaaa     2940

tgaggaaatt gcatcgcatt gtctgagtag gtgtcattct attctggggg gtggggtggg     3000

gcaggacagc aagggggagg attgggaaga caatagcagg catgctgggg atgcggtggg     3060

ctctatgggt acccaggtgc tgaagaattg acccggttcc tcctgggcca gaaagaagca     3120

ggcacatccc cttctctgtg acacaccctg tccacgcccc tggttcttag ttccagcccc     3180

actcatagga cactcatagc tcaggagggc tccgccttca atcccacccg ctaaagtact     3240

tggagcggtc tctccctccc tcatcagccc accaaaccaa acctagcctc caagagtggg     3300

aagaaattaa agcaagatag gctattaagt gcagagggag agaaaatgcc tccaacatgt     3360

gaggaagtaa tgagagaaat catagaattt taaggccatg atttaaggcc atcatggcct     3420

taatcttccg cttcctcgct cactgactcg ctgcgctcgg tcgttcggct gcggcgagcg     3480

gtatcagctc actcaaaggc ggtaatacgg ttatccacag aatcagggga taacgcagga     3540

aagaacatgt gagcaaaagg ccagcaaaag gccaggaacc gtaaaaaggc cgcgttgctg     3600

gcgtttttcc ataggctccg cccccctgac gagcatcaca aaaatcgacg ctcaagtcag     3660

aggtggcgaa acccgacagg actataaaga taccaggcgt ttccccctgg aagctccctc     3720

gtgcgctctc ctgttccgac cctgccgctt accggatacc tgtccgcctt tctcccttcg     3780

ggaagcgtgg cgctttctca tagctcacgc tgtaggtatc tcagttcggt gtaggtcgtt     3840

cgctccaagc tgggctgtgt gcacgaaccc cccgttcagc ccgaccgctg cgccttatcc     3900

ggtaactatc gtcttgagtc caacccggta agacacgact tatcgccact ggcagcagcc     3960

actggtaaca ggattagcag agcgaggtat gtaggcggtg ctacagagtt cttgaagtgg     4020

tggcctaact acggctacac tagaagaaca gtatttggta tctgcgctct gctgaagcca     4080

gttaccttcg gaaaaagagt tggtagctct tgatccggca aacaaaccac cgctggtagc     4140

ggtggttttt ttgtttgcaa gcagcagatt acgcgcagaa aaaaaggatc tcaagaagat     4200

cctttgatct tttctacggg gtctgacgct cagtggaacg aaaactcacg ttaagggatt     4260

ttggtcatga gattatcaaa aaggatcttc acctagatcc ttttaaatta aaaatgaagt     4320

tttaaatcaa tctaaagtat atatgagtaa acttggtctg acagttacca atgcttaatc     4380

agtgaggcac ctatctcagc gatctgtcta tttcgttcat ccatagttgc ctgactcggg     4440

gggggggggc gctgaggtct gcctcgtgaa gaaggtgttg ctgactcata ccaggcctga     4500

atcgccccat catccagcca gaaagtgagg gagccacggt tgatgagagc tttgttgtag     4560

gtggaccagt tggtgatttt gaacttttgc tttgccacgg aacggtctgc gttgtcggga     4620

agatgcgtga tctgatcctt caactcagca aaagttcgat ttattcaaca aagccgccgt     4680

cccgtcaagt cagcgtaatg ctctgccagt gttacaacca attaaccaat tctgattaga     4740

aaaactcatc gagcatcaaa tgaaactgca atttattcat atcaggatta tcaataccat     4800

atttttgaaa aagccgtttc tgtaatgaag gagaaaactc accgaggcag ttccatagga     4860

tggcaagatc ctggtatcgg tctgcgattc cgactcgtcc aacatcaata caacctatta     4920

atttcccctc gtcaaaaata aggttatcaa gtgagaaatc accatgagtg acgactgaat     4980

ccggtgagaa tggcaaaagc ttatgcattt ctttccagac ttgttcaaca ggccagccat     5040

tacgctcgtc atcaaaatca ctcgcatcaa ccaaaccgtt attcattcgt gattgcgcct     5100

gagcgagacg aaatacgcga tcgctgttaa aaggacaatt acaaacagga atcgaatgca     5160

accggcgcag gaacactgcc agcgcatcaa caatattttc acctgaatca ggatattctt     5220

ctaatacctg gaatgctgtt ttcccgggga tcgcagtggt gagtaaccat gcatcatcag     5280

gagtacggat aaaatgcttg atggtcggaa gaggcataaa ttccgtcagc cagtttagtc     5340

tgaccatctc atctgtaaca tcattggcaa cgctaccttt gccatgtttc agaaacaact     5400

ctggcgcatc gggcttccca tacaatcgat agattgtcgc acctgattgc ccgacattat     5460

cgcgagccca tttataccca tataaatcag catccatgtt ggaatttaat cgcggcctcg     5520

agcaagacgt ttcccgttga atatggctca taacacccct tgtattactg tttatgtaag     5580

cagacagttt tattgttcat gatgatatat ttttatcttg tgcaatgtaa catcagagat     5640

tttgagacac aacgtggctt tccccccccc cccattattg aagcatttat cagggttatt     5700

gtctcatgag cggatacata tttgaatgta tttagaaaaa taaacaaata ggggttccgc     5760

gcacatttcc ccgaaaagtg ccacctgacg tctaagaaac cattattatc atgacattaa     5820

cctataaaaa taggcgtatc acgaggccct ttcgtc                               5856


<210>  81
<211>  5856
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant Antibody Sequence

<400>  81
tcgcgcgttt cggtgatgac ggtgaaaacc tctgacacat gcagctcccg gagacggtca       60

cagcttgtct gtaagcggat gccgggagca gacaagcccg tcagggcgcg tcagcgggtg      120

ttggcgggtg tcggggctgg cttaactatg cggcatcaga gcagattgta ctgagagtgc      180

accatatgcg gtgtgaaata ccgcacagat gcgtaaggag aaaataccgc atcagattgg      240

ctattggcca ttgcatacgt tgtatccata tcataatatg tacatttata ttggctcatg      300

tccaacatta ccgccatgtt gacattgatt attgactagt tattaatagt aatcaattac      360

ggggtcatta gttcatagcc catatatgga gttccgcgtt acataactta cggtaaatgg      420

cccgcctggc tgaccgccca acgacccccg cccattgacg tcaataatga cgtatgttcc      480

catagtaacg ccaataggga ctttccattg acgtcaatgg gtggagtatt tacggtaaac      540

tgcccacttg gcagtacatc aagtgtatca tatgccaagt acgcccccta ttgacgtcaa      600

tgacggtaaa tggcccgcct ggcattatgc ccagtacatg accttatggg actttcctac      660

ttggcagtac atctacgtat tagtcatcgc tattaccatg gtgatgcggt tttggcagta      720

catcaatggg cgtggatagc ggtttgactc acggggattt ccaagtctcc accccattga      780

cgtcaatggg agtttgtttt ggcaccaaaa tcaacgggac tttccaaaat gtcgtaacaa      840

ctccgcccca ttgacgcaaa tgggcggtag gcgtgtacgg tgggaggtct atataagcag      900

agctcgttta gtgaaccgtc agatcgcctg gagacgccat ccacgctgtt ttgacctcca      960

tagaagacac cgggaccgat ccagcctcca tcggctcgca tctctccttc acgcgcccgc     1020

cgccctacct gaggccgcca tccacgccgg ttgagtcgcg ttctgccgcc tcccgcctgt     1080

ggtgcctcct gaactgcgtc cgccgtctag gtaagtttaa agctcaggtc gagaccgggc     1140

ctttgtccgg cgctcccttg gagcctacct agactcagcc ggctctccac gctttgcctg     1200

accctgcttg ctcaactcta gttaacggtg gagggcagtg tagtctgagc agtactcgtt     1260

gctgccgcgc gcgccaccag acataatagc tgacagacta acagactgtt cctttccatg     1320

ggtcttttct gcagtcaccg tcgtcgacac gtgtgatcag atatcgcggc cgctctagac     1380

caccatggga tggtcatgta tcatcctttt tctagtagca actgcaaccg gtgtacattc     1440

tgaggttaga ctgcgggagt caggaggggg gcttgtgaag cccggtgggt ctctccgcct     1500

gagctgttct gcctccggct ttgatttcga taacgcctgg atgacctggg tcaggcagcc     1560

tccaggtaag ggactggagt gggtgggaag aatcacaggt ccaggcgagg gctggtccgt     1620

ggactacgcg gaatctgtta aagggcggtt tacaatctca agggacaata ccaagaatac     1680

cttgtatttg gagatgaaca acgtgagaac tgaagacacc ggatattact tctgtgccag     1740

aacaggcaaa tactacgact tctggttcgg ctatccccct ggcgaggaat attttcaaga     1800

ctggggtcag ggaacccttg ttatcgtgtc ctccgcgtcg accaagggcc catcggtctt     1860

ccccctggca ccctcctcca agagcacctc tgggggcaca gcggccctgg gctgcctggt     1920

caaggactac ttccccgaac cggtgacggt gtcgtggaac tcaggcgccc tgaccagcgg     1980

cgtgcacacc ttcccggctg tcctacagtc ctcaggactc tactccctca gcagcgtggt     2040

gaccgtgccc tccagcagct tgggcaccca gacctacatc tgcaacgtga atcacaagcc     2100

cagcaacacc aaggtggaca agaaagttga gcccaaatct tgtgacaaaa ctcacacatg     2160

cccaccgtgc ccagcacctg aactcctggg gggaccgtca gtcttcctct tccccccaaa     2220

acccaaggac accctcatga tctcccggac ccctgaggtc acatgcgtgg tggtggacgt     2280

gagccacgaa gaccctgagg tcaagttcaa ctggtacgtg gacggcgtgg aggtgcataa     2340

tgccaagaca aagccgcggg aggagcagta caacagcacg taccgtgtgg tcagcgtcct     2400

caccgtcctg caccaggact ggctgaatgg caaggagtac aagtgcaagg tctccaacaa     2460

agccctccca gcccccatcg agaaaaccat ctccaaagcc aaagggcagc cccgagaacc     2520

acaggtgtac accctgcccc catcccggga tgagctgacc aagaaccagg tcagcctgac     2580

ctgcctggtc aaaggcttct atcccagcga catcgccgtg gagtgggaga gcaatgggca     2640

gccggagaac aactacaaga ccacgcctcc cgtgctggac tccgacggct ccttcttcct     2700

ctacagcaag ctcaccgtgg acaagagcag gtggcagcag gggaacgtct tctcatgctc     2760

cgtgatgcat gaggctctgc acaaccacta cacgcagaag agcctctccc tgtctccggg     2820

taaatgatga ggatccagat ctgctgtgcc ttctagttgc cagccatctg ttgtttgccc     2880

ctcccccgtg ccttccttga ccctggaagg tgccactccc actgtccttt cctaataaaa     2940

tgaggaaatt gcatcgcatt gtctgagtag gtgtcattct attctggggg gtggggtggg     3000

gcaggacagc aagggggagg attgggaaga caatagcagg catgctgggg atgcggtggg     3060

ctctatgggt acccaggtgc tgaagaattg acccggttcc tcctgggcca gaaagaagca     3120

ggcacatccc cttctctgtg acacaccctg tccacgcccc tggttcttag ttccagcccc     3180

actcatagga cactcatagc tcaggagggc tccgccttca atcccacccg ctaaagtact     3240

tggagcggtc tctccctccc tcatcagccc accaaaccaa acctagcctc caagagtggg     3300

aagaaattaa agcaagatag gctattaagt gcagagggag agaaaatgcc tccaacatgt     3360

gaggaagtaa tgagagaaat catagaattt taaggccatg atttaaggcc atcatggcct     3420

taatcttccg cttcctcgct cactgactcg ctgcgctcgg tcgttcggct gcggcgagcg     3480

gtatcagctc actcaaaggc ggtaatacgg ttatccacag aatcagggga taacgcagga     3540

aagaacatgt gagcaaaagg ccagcaaaag gccaggaacc gtaaaaaggc cgcgttgctg     3600

gcgtttttcc ataggctccg cccccctgac gagcatcaca aaaatcgacg ctcaagtcag     3660

aggtggcgaa acccgacagg actataaaga taccaggcgt ttccccctgg aagctccctc     3720

gtgcgctctc ctgttccgac cctgccgctt accggatacc tgtccgcctt tctcccttcg     3780

ggaagcgtgg cgctttctca tagctcacgc tgtaggtatc tcagttcggt gtaggtcgtt     3840

cgctccaagc tgggctgtgt gcacgaaccc cccgttcagc ccgaccgctg cgccttatcc     3900

ggtaactatc gtcttgagtc caacccggta agacacgact tatcgccact ggcagcagcc     3960

actggtaaca ggattagcag agcgaggtat gtaggcggtg ctacagagtt cttgaagtgg     4020

tggcctaact acggctacac tagaagaaca gtatttggta tctgcgctct gctgaagcca     4080

gttaccttcg gaaaaagagt tggtagctct tgatccggca aacaaaccac cgctggtagc     4140

ggtggttttt ttgtttgcaa gcagcagatt acgcgcagaa aaaaaggatc tcaagaagat     4200

cctttgatct tttctacggg gtctgacgct cagtggaacg aaaactcacg ttaagggatt     4260

ttggtcatga gattatcaaa aaggatcttc acctagatcc ttttaaatta aaaatgaagt     4320

tttaaatcaa tctaaagtat atatgagtaa acttggtctg acagttacca atgcttaatc     4380

agtgaggcac ctatctcagc gatctgtcta tttcgttcat ccatagttgc ctgactcggg     4440

gggggggggc gctgaggtct gcctcgtgaa gaaggtgttg ctgactcata ccaggcctga     4500

atcgccccat catccagcca gaaagtgagg gagccacggt tgatgagagc tttgttgtag     4560

gtggaccagt tggtgatttt gaacttttgc tttgccacgg aacggtctgc gttgtcggga     4620

agatgcgtga tctgatcctt caactcagca aaagttcgat ttattcaaca aagccgccgt     4680

cccgtcaagt cagcgtaatg ctctgccagt gttacaacca attaaccaat tctgattaga     4740

aaaactcatc gagcatcaaa tgaaactgca atttattcat atcaggatta tcaataccat     4800

atttttgaaa aagccgtttc tgtaatgaag gagaaaactc accgaggcag ttccatagga     4860

tggcaagatc ctggtatcgg tctgcgattc cgactcgtcc aacatcaata caacctatta     4920

atttcccctc gtcaaaaata aggttatcaa gtgagaaatc accatgagtg acgactgaat     4980

ccggtgagaa tggcaaaagc ttatgcattt ctttccagac ttgttcaaca ggccagccat     5040

tacgctcgtc atcaaaatca ctcgcatcaa ccaaaccgtt attcattcgt gattgcgcct     5100

gagcgagacg aaatacgcga tcgctgttaa aaggacaatt acaaacagga atcgaatgca     5160

accggcgcag gaacactgcc agcgcatcaa caatattttc acctgaatca ggatattctt     5220

ctaatacctg gaatgctgtt ttcccgggga tcgcagtggt gagtaaccat gcatcatcag     5280

gagtacggat aaaatgcttg atggtcggaa gaggcataaa ttccgtcagc cagtttagtc     5340

tgaccatctc atctgtaaca tcattggcaa cgctaccttt gccatgtttc agaaacaact     5400

ctggcgcatc gggcttccca tacaatcgat agattgtcgc acctgattgc ccgacattat     5460

cgcgagccca tttataccca tataaatcag catccatgtt ggaatttaat cgcggcctcg     5520

agcaagacgt ttcccgttga atatggctca taacacccct tgtattactg tttatgtaag     5580

cagacagttt tattgttcat gatgatatat ttttatcttg tgcaatgtaa catcagagat     5640

tttgagacac aacgtggctt tccccccccc cccattattg aagcatttat cagggttatt     5700

gtctcatgag cggatacata tttgaatgta tttagaaaaa taaacaaata ggggttccgc     5760

gcacatttcc ccgaaaagtg ccacctgacg tctaagaaac cattattatc atgacattaa     5820

cctataaaaa taggcgtatc acgaggccct ttcgtc                               5856


<210>  82
<211>  461
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant Antibody Sequence

<400>  82

Glu Val Arg Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Phe Asp Phe Asp Asn Ala 
            20                  25                  30          


Trp Met Thr Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Thr Gly Pro Gly Glu Gly Trp Ser Val Asp Tyr Ala Glu 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Thr Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Glu Met Asn Asn Val Arg Thr Glu Asp Thr Gly Tyr Tyr 
                85                  90                  95      


Phe Cys Ala Arg Thr Gly Lys Tyr Tyr Asp Phe Trp Phe Gly Tyr Pro 
            100                 105                 110         


Pro Gly Glu Glu Tyr Phe Gln Asp Trp Gly Gln Gly Thr Leu Val Ile 
        115                 120                 125             


Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
    130                 135                 140                 


Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val 
145                 150                 155                 160 


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
                165                 170                 175     


Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
            180                 185                 190         


Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 
        195                 200                 205             


Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys 
    210                 215                 220                 


Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys 
225                 230                 235                 240 


Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 
                245                 250                 255     


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
            260                 265                 270         


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
        275                 280                 285             


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
    290                 295                 300                 


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
305                 310                 315                 320 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
                325                 330                 335     


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
            340                 345                 350         


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
        355                 360                 365             


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
    370                 375                 380                 


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
385                 390                 395                 400 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
                405                 410                 415     


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
            420                 425                 430         


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
        435                 440                 445             


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455                 460     


<210>  83
<211>  461
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant Antibody Sequence

<400>  83

Glu Val Arg Leu Arg Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Phe Asp Phe Asp Asn Ala 
            20                  25                  30          


Trp Met Thr Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Thr Gly Pro Gly Glu Gly Trp Ser Val Asp Tyr Ala Glu 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Thr Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Glu Met Asn Asn Val Arg Thr Glu Asp Thr Gly Tyr Tyr 
                85                  90                  95      


Phe Cys Ala Arg Thr Gly Lys Tyr Tyr Asp Phe Trp Phe Gly Tyr Pro 
            100                 105                 110         


Pro Gly Glu Glu Tyr Phe Gln Asp Trp Gly Gln Gly Thr Leu Val Ile 
        115                 120                 125             


Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
    130                 135                 140                 


Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val 
145                 150                 155                 160 


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
                165                 170                 175     


Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
            180                 185                 190         


Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 
        195                 200                 205             


Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys 
    210                 215                 220                 


Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys 
225                 230                 235                 240 


Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 
                245                 250                 255     


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
            260                 265                 270         


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
        275                 280                 285             


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
    290                 295                 300                 


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
305                 310                 315                 320 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
                325                 330                 335     


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
            340                 345                 350         


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
        355                 360                 365             


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
    370                 375                 380                 


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
385                 390                 395                 400 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
                405                 410                 415     


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
            420                 425                 430         


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
        435                 440                 445             


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455                 460     


<210>  84
<211>  215
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant Antibody Sequence

<400>  84

Ala Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Lys Gln 
1               5                   10                  15      


Thr Val Thr Ile Thr Cys Arg Gly Asp Ser Leu Arg Ser His Tyr Ala 
            20                  25                  30          


Ser Trp Tyr Gln Lys Lys Pro Gly Gln Ala Pro Val Leu Leu Phe Tyr 
        35                  40                  45              


Gly Lys Asn Asn Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  


Ala Ser Gly Asn Arg Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Arg Asp Lys Ser Gly Ser Arg 
                85                  90                  95      


Leu Ser Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Ser Gln Pro 
            100                 105                 110         


Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu 
        115                 120                 125             


Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro 
    130                 135                 140                 


Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala 
145                 150                 155                 160 


Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala 
                165                 170                 175     


Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg 
            180                 185                 190         


Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr 
        195                 200                 205             


Val Ala Pro Thr Glu Cys Ser 
    210                 215 


<210>  85
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant Antibody Sequence

<400>  85

Ser Leu Arg Cys His Trp 
1               5       


<210>  86
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant Antibody Sequence

<400>  86

Ser Leu Arg Cys His Phe 
1               5       


