                         SEQUENCE LISTING

<110>  The United States of America, as represented by the
       Secretary, Department of Health and Human Services
 
<120>  METHODS OF PRODUCING T CELL POPULATIONS USING PROLYL HYDROXYLASE 
       DOMAIN-CONTAINING PROTEIN INHIBITORS

<130>  726756

<150>  62/249,645
<151>  2015-11-02

<160>  14    

<170>  PatentIn version 3.5

<210>  1
<211>  2264
<212>  DNA
<213>  Homo sapiens

<400>  1
tgggtgccgg ccgttgtggg ggttggggtg ggggcgggga gcgcgcgccg ggcggaggcc       60

gagtggaggg ggaggggagg gggtccgagc ggcccttagg ccctgcccct gtcgcctact      120

gcgctcagaa ggggcctcag ggcctgcccc gggttggggg cgttggggtg ccctggatgg      180

gggcaccttt atctctcgtc ctgtctccgg ccaccctgaa gggtcccttc ccaagccctt      240

agggaccgca gaggacttgg ggaccagcaa gcaaccccca gggcacgaga agagctcttg      300

ctgtctgccc tgcctcaccc tgccccacgc caggcccggt ggcccccagc tgcatcaagt      360

ggaggcggag gaggaggcgg aggagggtgg caccatgggc ccgggcggtg ccctccatgc      420

ccgggggatg aagacactgc tgccatggac agcccgtgcc agccgcagcc cctaagtcag      480

gctctccctc agttaccagg gtcttcgtca gagcccttgg agcctgagcc tggccgggcc      540

aggatgggag tggagagtta cctgccctgt cccctgctcc cctcctacca ctgtccagga      600

gtgcctagtg aggcctcggc agggagtggg acccccagag ccacagccac ctctaccact      660

gccagccctc ttcgggacgg ttttggcggg caggatggtg gtgagctgcg gccgctgcag      720

agtgaaggcg ctgcagcgct ggtcaccaag gggtgccagc gattggcagc ccagggcgca      780

cggcctgagg cccccaaacg gaaatgggcc gaggatggtg gggatgcccc ttcacccagc      840

aaacggccct gggccaggca agagaaccag gaggcagagc gggagggtgg catgagctgc      900

agctgcagca gtggcagtgg tgaggccagt gctgggctga tggaggaggc gctgccctct      960

gcgcccgagc gcctggccct ggactatatc gtgccctgca tgcggtacta cggcatctgc     1020

gtcaaggaca gcttcctggg ggcagcactg ggcggtcgcg tgctggccga ggtggaggcc     1080

ctcaaacggg gtgggcgcct gcgagacggg cagctagtga gccagagggc gatcccgccg     1140

cgcagcatcc gtggggacca gattgcctgg gtggaaggcc atgaaccagg ctgtcgaagc     1200

attggtgccc tcatggccca tgtggacgcc gtcatccgcc actgcgcagg gcggctgggc     1260

agctatgtca tcaacgggcg caccaaggcc atggtggcgt gttacccagg caacgggctc     1320

gggtacgtaa ggcacgttga caatccccac ggcgatgggc gctgcatcac ctgtatctat     1380

tacctgaatc agaactggga cgttaaggtg catggcggcc tgctgcagat cttccctgag     1440

ggccggcccg tggtagccaa catcgagcca ctctttgacc ggttgctcat tttctggtct     1500

gaccggcgga acccccacga ggtgaagcca gcctatgcca ccaggtacgc catcactgtc     1560

tggtattttg atgccaagga gcgggcagca gccaaagaca agtatcagct agcatcagga     1620

cagaaaggtg tccaagtacc tgtatcacag ccgcctacgc ccacctagtg gccagtccca     1680

gagccgcatg gcagacagct taaatgactt caggagagcc ctgggcctgt gctggctgct     1740

ccttccctgc caccgctgct gcttctgact ttgcctctgt cctgcctggt gtggagggct     1800

ctgtctgttg ctgaggacca aggaggagaa gagacctttg ctgccccatc atgggggctg     1860

gggttgtcac ctggacaggg ggcagccgtg gaggccaccg ttaccaactg aagctggggg     1920

cctgggtcct accctgtctg gtcatgaccc cattaggtat ggagagctgg gaggaggcat     1980

tgtcacttcc caccaggatg caggacttgg ggttgaggtg agtcatggcc tcttgctggc     2040

aatggggtgg gaggagtacc cccaagtcct ctcactcctc cagcctggaa tgtgaagtga     2100

ctccccaacc cctttggcca tggcaggcac cttttggact gggctgccac tgcttgggca     2160

gagtaaaagg tgccaggagg agcatgggtg tggaagtcct gtcagccaag aaataaaagt     2220

ttacctcaga gctgcacaca tctgaaaaaa aaaaaaaaaa aaaa                      2264


<210>  2
<211>  2174
<212>  DNA
<213>  Homo sapiens

<400>  2
acgtgcccac cgggcgaggc ggggcggggc gtcgcgcgcg gtgggggcgg ggtatggcgc       60

gctgtgcggc gcagggcggc tggcacaaac ggcggcgccg gggccggagg aaaaagctcg      120

ccaccctgaa gggtcccttc ccaagccctt agggaccgca gaggacttgg ggaccagcaa      180

gcaaccccca gggcacgaga agagctcttg ctgtctgccc tgcctcaccc tgccccacgc      240

caggcccggt ggcccccagc tgcatcaagt ggaggcggag gaggaggcgg aggagggtgg      300

caccatgggc ccgggcggtg ccctccatgc ccgggggatg aagacactgc tgccatggac      360

agcccgtgcc agccgcagcc cctaagtcag gctctccctc agttaccagg gtcttcgtca      420

gagcccttgg agcctgagcc tggccgggcc aggatgggag tggagagtta cctgccctgt      480

cccctgctcc cctcctacca ctgtccagga gtgcctagtg aggcctcggc agggagtggg      540

acccccagag ccacagccac ctctaccact gccagccctc ttcgggacgg ttttggcggg      600

caggatggtg gtgagctgcg gccgctgcag agtgaaggcg ctgcagcgct ggtcaccaag      660

gggtgccagc gattggcagc ccagggcgca cggcctgagg cccccaaacg gaaatgggcc      720

gaggatggtg gggatgcccc ttcacccagc aaacggccct gggccaggca agagaaccag      780

gaggcagagc gggagggtgg catgagctgc agctgcagca gtggcagtgg tgaggccagt      840

gctgggctga tggaggaggc gctgccctct gcgcccgagc gcctggccct ggactatatc      900

gtgccctgca tgcggtacta cggcatctgc gtcaaggaca gcttcctggg ggcagcactg      960

ggcggtcgcg tgctggccga ggtggaggcc ctcaaacggg gtgggcgcct gcgagacggg     1020

cagctagtga gccagagggc gatcccgccg cgcagcatcc gtggggacca gattgcctgg     1080

gtggaaggcc atgaaccagg ctgtcgaagc attggtgccc tcatggccca tgtggacgcc     1140

gtcatccgcc actgcgcagg gcggctgggc agctatgtca tcaacgggcg caccaaggcc     1200

atggtggcgt gttacccagg caacgggctc gggtacgtaa ggcacgttga caatccccac     1260

ggcgatgggc gctgcatcac ctgtatctat tacctgaatc agaactggga cgttaaggtg     1320

catggcggcc tgctgcagat cttccctgag ggccggcccg tggtagccaa catcgagcca     1380

ctctttgacc ggttgctcat tttctggtct gaccggcgga acccccacga ggtgaagcca     1440

gcctatgcca ccaggtacgc catcactgtc tggtattttg atgccaagga gcgggcagca     1500

gccaaagaca agtatcagct agcatcagga cagaaaggtg tccaagtacc tgtatcacag     1560

ccgcctacgc ccacctagtg gccagtccca gagccgcatg gcagacagct taaatgactt     1620

caggagagcc ctgggcctgt gctggctgct ccttccctgc caccgctgct gcttctgact     1680

ttgcctctgt cctgcctggt gtggagggct ctgtctgttg ctgaggacca aggaggagaa     1740

gagacctttg ctgccccatc atgggggctg gggttgtcac ctggacaggg ggcagccgtg     1800

gaggccaccg ttaccaactg aagctggggg cctgggtcct accctgtctg gtcatgaccc     1860

cattaggtat ggagagctgg gaggaggcat tgtcacttcc caccaggatg caggacttgg     1920

ggttgaggtg agtcatggcc tcttgctggc aatggggtgg gaggagtacc cccaagtcct     1980

ctcactcctc cagcctggaa tgtgaagtga ctccccaacc cctttggcca tggcaggcac     2040

cttttggact gggctgccac tgcttgggca gagtaaaagg tgccaggagg agcatgggtg     2100

tggaagtcct gtcagccaag aaataaaagt ttacctcaga gctgcacaca tctgaaaaaa     2160

aaaaaaaaaa aaaa                                                       2174


<210>  3
<211>  407
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Asp Ser Pro Cys Gln Pro Gln Pro Leu Ser Gln Ala Leu Pro Gln 
1               5                   10                  15      


Leu Pro Gly Ser Ser Ser Glu Pro Leu Glu Pro Glu Pro Gly Arg Ala 
            20                  25                  30          


Arg Met Gly Val Glu Ser Tyr Leu Pro Cys Pro Leu Leu Pro Ser Tyr 
        35                  40                  45              


His Cys Pro Gly Val Pro Ser Glu Ala Ser Ala Gly Ser Gly Thr Pro 
    50                  55                  60                  


Arg Ala Thr Ala Thr Ser Thr Thr Ala Ser Pro Leu Arg Asp Gly Phe 
65                  70                  75                  80  


Gly Gly Gln Asp Gly Gly Glu Leu Arg Pro Leu Gln Ser Glu Gly Ala 
                85                  90                  95      


Ala Ala Leu Val Thr Lys Gly Cys Gln Arg Leu Ala Ala Gln Gly Ala 
            100                 105                 110         


Arg Pro Glu Ala Pro Lys Arg Lys Trp Ala Glu Asp Gly Gly Asp Ala 
        115                 120                 125             


Pro Ser Pro Ser Lys Arg Pro Trp Ala Arg Gln Glu Asn Gln Glu Ala 
    130                 135                 140                 


Glu Arg Glu Gly Gly Met Ser Cys Ser Cys Ser Ser Gly Ser Gly Glu 
145                 150                 155                 160 


Ala Ser Ala Gly Leu Met Glu Glu Ala Leu Pro Ser Ala Pro Glu Arg 
                165                 170                 175     


Leu Ala Leu Asp Tyr Ile Val Pro Cys Met Arg Tyr Tyr Gly Ile Cys 
            180                 185                 190         


Val Lys Asp Ser Phe Leu Gly Ala Ala Leu Gly Gly Arg Val Leu Ala 
        195                 200                 205             


Glu Val Glu Ala Leu Lys Arg Gly Gly Arg Leu Arg Asp Gly Gln Leu 
    210                 215                 220                 


Val Ser Gln Arg Ala Ile Pro Pro Arg Ser Ile Arg Gly Asp Gln Ile 
225                 230                 235                 240 


Ala Trp Val Glu Gly His Glu Pro Gly Cys Arg Ser Ile Gly Ala Leu 
                245                 250                 255     


Met Ala His Val Asp Ala Val Ile Arg His Cys Ala Gly Arg Leu Gly 
            260                 265                 270         


Ser Tyr Val Ile Asn Gly Arg Thr Lys Ala Met Val Ala Cys Tyr Pro 
        275                 280                 285             


Gly Asn Gly Leu Gly Tyr Val Arg His Val Asp Asn Pro His Gly Asp 
    290                 295                 300                 


Gly Arg Cys Ile Thr Cys Ile Tyr Tyr Leu Asn Gln Asn Trp Asp Val 
305                 310                 315                 320 


Lys Val His Gly Gly Leu Leu Gln Ile Phe Pro Glu Gly Arg Pro Val 
                325                 330                 335     


Val Ala Asn Ile Glu Pro Leu Phe Asp Arg Leu Leu Ile Phe Trp Ser 
            340                 345                 350         


Asp Arg Arg Asn Pro His Glu Val Lys Pro Ala Tyr Ala Thr Arg Tyr 
        355                 360                 365             


Ala Ile Thr Val Trp Tyr Phe Asp Ala Lys Glu Arg Ala Ala Ala Lys 
    370                 375                 380                 


Asp Lys Tyr Gln Leu Ala Ser Gly Gln Lys Gly Val Gln Val Pro Val 
385                 390                 395                 400 


Ser Gln Pro Pro Thr Pro Thr 
                405         


<210>  4
<211>  407
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Asp Ser Pro Cys Gln Pro Gln Pro Leu Ser Gln Ala Leu Pro Gln 
1               5                   10                  15      


Leu Pro Gly Ser Ser Ser Glu Pro Leu Glu Pro Glu Pro Gly Arg Ala 
            20                  25                  30          


Arg Met Gly Val Glu Ser Tyr Leu Pro Cys Pro Leu Leu Pro Ser Tyr 
        35                  40                  45              


His Cys Pro Gly Val Pro Ser Glu Ala Ser Ala Gly Ser Gly Thr Pro 
    50                  55                  60                  


Arg Ala Thr Ala Thr Ser Thr Thr Ala Ser Pro Leu Arg Asp Gly Phe 
65                  70                  75                  80  


Gly Gly Gln Asp Gly Gly Glu Leu Arg Pro Leu Gln Ser Glu Gly Ala 
                85                  90                  95      


Ala Ala Leu Val Thr Lys Gly Cys Gln Arg Leu Ala Ala Gln Gly Ala 
            100                 105                 110         


Arg Pro Glu Ala Pro Lys Arg Lys Trp Ala Glu Asp Gly Gly Asp Ala 
        115                 120                 125             


Pro Ser Pro Ser Lys Arg Pro Trp Ala Arg Gln Glu Asn Gln Glu Ala 
    130                 135                 140                 


Glu Arg Glu Gly Gly Met Ser Cys Ser Cys Ser Ser Gly Ser Gly Glu 
145                 150                 155                 160 


Ala Ser Ala Gly Leu Met Glu Glu Ala Leu Pro Ser Ala Pro Glu Arg 
                165                 170                 175     


Leu Ala Leu Asp Tyr Ile Val Pro Cys Met Arg Tyr Tyr Gly Ile Cys 
            180                 185                 190         


Val Lys Asp Ser Phe Leu Gly Ala Ala Leu Gly Gly Arg Val Leu Ala 
        195                 200                 205             


Glu Val Glu Ala Leu Lys Arg Gly Gly Arg Leu Arg Asp Gly Gln Leu 
    210                 215                 220                 


Val Ser Gln Arg Ala Ile Pro Pro Arg Ser Ile Arg Gly Asp Gln Ile 
225                 230                 235                 240 


Ala Trp Val Glu Gly His Glu Pro Gly Cys Arg Ser Ile Gly Ala Leu 
                245                 250                 255     


Met Ala His Val Asp Ala Val Ile Arg His Cys Ala Gly Arg Leu Gly 
            260                 265                 270         


Ser Tyr Val Ile Asn Gly Arg Thr Lys Ala Met Val Ala Cys Tyr Pro 
        275                 280                 285             


Gly Asn Gly Leu Gly Tyr Val Arg His Val Asp Asn Pro His Gly Asp 
    290                 295                 300                 


Gly Arg Cys Ile Thr Cys Ile Tyr Tyr Leu Asn Gln Asn Trp Asp Val 
305                 310                 315                 320 


Lys Val His Gly Gly Leu Leu Gln Ile Phe Pro Glu Gly Arg Pro Val 
                325                 330                 335     


Val Ala Asn Ile Glu Pro Leu Phe Asp Arg Leu Leu Ile Phe Trp Ser 
            340                 345                 350         


Asp Arg Arg Asn Pro His Glu Val Lys Pro Ala Tyr Ala Thr Arg Tyr 
        355                 360                 365             


Ala Ile Thr Val Trp Tyr Phe Asp Ala Lys Glu Arg Ala Ala Ala Lys 
    370                 375                 380                 


Asp Lys Tyr Gln Leu Ala Ser Gly Gln Lys Gly Val Gln Val Pro Val 
385                 390                 395                 400 


Ser Gln Pro Pro Thr Pro Thr 
                405         


<210>  5
<211>  7102
<212>  DNA
<213>  Homo sapiens

<400>  5
ttaggggcag aaaaacattt gtaataatta atggctttga gagacacaag gctttgtttg       60

ccccagagta ttagttaacc cacctagtgc tcctaatcat acaatattaa ggattgggag      120

ggacattcat tgcctcactc tctatttgtt tcaccttctg taaaattggt agaataatag      180

tacccacttc atagcattgt atgatgatta aattggttaa tatttttaaa atgcttagaa      240

cacagattgg gcacataaca gcaagcacca catgtgttta taagataaat tcctttgtgt      300

tgccttccgt taaagtttaa ataagtaaat aaataaataa atacttgcat gacattttga      360

agtctctcta taacatctga gtaagtggcg gctgcgacaa tgctactgga gttccagaat      420

cgtgttggtg acaagattgt tcaccagcat atggtgtggt gaaaactcac taatttggaa      480

ttagttcaga ttattaagcc tgaataggtg aaaatcctga aatcaaggat ctttggaact      540

atttgaaatc agtattttat attttcctgt tgtattcatt aaagtgttgc aagtgttcta      600

tttgatggat taagtatatt taggatatac atgttcaatt tgtgattttg tatacttaat      660

tggaacaaga aagctaataa aggttttgat atggacatct attcttttaa gtaaacttca      720

atgaaaatat atgagtagag catatagaga tgtaaataat ttgtggacac accacagact      780

gaaatagcaa atttaaaaga aattgttgga agaatcaagt gtttgtggaa tgagtcctcc      840

tagtaaagtt cctgctcttg tgaataatta agcctcatgt ataattacta tagcaaaagg      900

aagcctaaga agtattagac tctacttgta tttaaattac attttacata atttatgtgt      960

atgaaaaatg ttttaaatgc ttattttcgt aagccatgag atagctcctt tatattttaa     1020

gaatttctga attaatttgc ttggatttta ttagtgcaaa tggcagagct agcaattcct     1080

ttttctgtgt tcccattcca tcctattcat ccctctttta ggaaactctg aactctggat     1140

tgtccttgtt tacatacctg cctcctgcat tggactatgt gtctctgagt gtagtatgac     1200

taattcattt gtttgtcaag gactctcaat gcatttgttg aacagcctaa ttagtaatgt     1260

ctgcaacaat gacattttac tgtatttaat aaagctctgg gaaagtagga tacacataag     1320

acaggtctag gtctaaattc tttacagaaa cttggatttt tagttcggtt tgaaatttga     1380

agatgtgagt atatttatct cagtttccca aaggacaagc taattggaat tatcatcctc     1440

tttcacttga ttggatcccc agaatgccat ttacgcatgc agcaggattt tataacagtt     1500

ttaaattctg tatatttgat gaagaggttt tatatttttg gattcaagcc tctttttaaa     1560

cttctacaat atggtttaca ataattcctt atatcctgct tttgaaatac atattacaac     1620

tttttaagtt tggaaggcta tatttcaagg actgaagtta cagtatactc aagtgataca     1680

caagcctagc accccacttt ccacatagtg ttcgataaag attgataaac tcgaaatcac     1740

agacctttta attcttaaga caaatagcag cagaaagaaa catctttggc ttatttctgg     1800

taaggttttt atgctctgta aaacaaagaa ttgtattcat ccgcgcagca cagattctat     1860

taaaaataaa tgtgagagtc gttaatgtag tactgctcat ttaccatcaa aattcacttt     1920

tcaggaataa tcccatcagt ttaaattgga tattggaatg agcattgatt acatttaact     1980

tggtagccca aaatttcttc atggggtttt gaactcggcg ggatttcaaa ggttttaaaa     2040

atgagttttt gatttttttt aaaaccctca aatttcatta cctttaaact aggtcgaaac     2100

ggggcgcaag agattggatt aacaccatag taatacttat tttgttctta accatttcag     2160

ggcttcttga aatagaggct gtatggtgta atggaaaaaa cagccttgga atctgggagc     2220

ctgattcctg gattcagtcc cagttttgcg tgaccttggg caagttactt tacttctctg     2280

aatttccgtt tcctcctctg caaaatgagg atcgcaatag ccaccttgca accttgactg     2340

gagcgagcct cgcacacccc gcgccggcct ggaggaagag cagccatgat tacgccgcct     2400

tcgctccgct acccgcttgc ggctggcgcc ctcctccagc aggtgtaggc gctgccgcgc     2460

tgccccacgc ctttccgccg ctcgcgggcc tgcgcctcgg cgtccccgag gaggccgctg     2520

cgggctgagg tagcgcaccg gcctctcggc gtcccagtcc ggtcccgggc ggagggaaag     2580

cgggcgaccc acctccgagg cagaagccga ggcccggccc cgccgagtgc ggaggagcgc     2640

aggcagcccc cgcccctcgg ccctcccccc ggccctcccg gccctccctc cgccccctcc     2700

gccctcgcgc gccgcccgcc cgggtcgccg cggggccgtg gtgtacgtgc agagcgcgca     2760

gagcgagtgg cgcccgtatg ccctgcgctc ctccacagcc tgggccgggc cgcccgggac     2820

gctgaggcgg cggcggcggc cgagggggcc ggtcttgcgc tccccaggcc cgcgcgcctg     2880

agcccaggtt gccattcgcc gcacaggccc tattctctca gccctcggcg gcgatgaggc     2940

gctgaggcgg ctgccggcgc tgcgccggag cttaggactc ggaagcggcc gggccgaggg     3000

cgtggggtgc cggcctccct gaggcgaggg tagcgggtgc atggcgcagt aacggcccct     3060

atctctctcc ccgctcccca gcctcgggcg aggccgtccg gccgctaccc ctcctgctcg     3120

gccgccgcag tcgccgtcgc cgccgccgcc gccgccatgg ccaatgacag cggcgggccc     3180

ggcgggccga gcccgagcga gcgagaccgg cagtactgcg agctgtgcgg gaagatggag     3240

aacctgctgc gctgcagccg ctgccgcagc tccttctact gctgcaagga gcaccagcgt     3300

caggactgga agaagcacaa gctcgtgtgc cagggcagcg agggcgccct cggccacgga     3360

gtgggcccac accagcattc cggccccgcg ccgccggctg cagtgccgcc gcccagggcc     3420

ggggcccggg agcccaggaa ggcagcggcg cgccgggaca acgcctccgg ggacgcggcc     3480

aagggaaaag taaaggccaa gcccccggcc gacccagcgg cggccgcgtc gccgtgtcgt     3540

gcggccgccg gcggccaggg ctcggcggtg gctgccgaag ccgagcccgg caaggaggag     3600

ccgccggccc gctcatcgct gttccaggag aaggcgaacc tgtacccccc aagcaacacg     3660

cccggggatg cgctgagccc cggcggcggc ctgcggccca acgggcagac gaagcccctg     3720

ccggcgctga agctggcgct cgagtacatc gtgccgtgca tgaacaagca cggcatctgt     3780

gtggtggacg acttcctcgg caaggagacc ggacagcaga tcggcgacga ggtgcgcgcc     3840

ctgcacgaca ccgggaagtt cacggacggg cagctggtca gccagaagag tgactcgtcc     3900

aaggacatcc gaggcgataa gatcacctgg atcgagggca aggagcccgg ctgcgaaacc     3960

attgggctgc tcatgagcag catggacgac ctgatacgcc actgtaacgg gaagctgggc     4020

agctacaaaa tcaatggccg gacgaaagcc atggttgctt gttatccggg caatggaacg     4080

ggttatgtac gtcatgttga taatccaaat ggagatggaa gatgtgtgac atgtatatat     4140

tatcttaata aagactggga tgccaaggta agtggaggta tacttcgaat ttttccagaa     4200

ggcaaagccc agtttgctga cattgaaccc aaatttgata gactgctgtt tttctggtct     4260

gaccgtcgca accctcatga agtacaacca gcatatgcta caaggtacgc aataactgtt     4320

tggtattttg atgcagatga gagagcacga gctaaagtaa aatatctaac aggtgaaaaa     4380

ggtgtgaggg ttgaactcaa taaaccttca gattcggtcg gtaaagacgt cttctagagc     4440

ctttgatcca gcaatacccc acttcaccta caatattgtt aactatttgt taacttgtga     4500

atacgaataa atgggataaa gaaaaataga caaccagttc gcattttaat aaggaaacag     4560

aaacaacttt ttgtgttgca tcaaacagaa gattttgact gctgtgactt tgtactgcat     4620

gatcaacttc aaatctgtga ttgcttacag gaggaagata agctactaat tgaaaatggt     4680

ttttacatct ggatatgaaa taagtgccct gtgtagaatt tttttcattc ttatattttg     4740

ccagatctgt tatctagctg agttcatttc atctctccct tttttatatc aagtttgaat     4800

ttgggataat ttttctatat taggtacaat ttatctaaac tgaattgaga aaaaattaca     4860

gtattattcc tcaaaataac atcaatctat ttttgtaaac ctgttcatac tattaaattt     4920

tgccctaaaa gacctcttaa taatgattgt tgccagtgac tgatgattaa ttttatttta     4980

cttaaaataa gaaaaggagc actttaatta caactgaaaa atcagattgt tttgtagtcc     5040

ttccttacac taatttgaac tgttaaagat tgctgctttt tttttgacat tgtcaataac     5100

gaaacctaat tgtaaaacag tcaccattta ctaccaataa cttttagtta atgttttaca     5160

aggaaaaaga cacaagaaga gtttaaattt ttttgttttg ttttgttttt ttgagacagt     5220

cttgctctgt tacccaggct ggaggggagt ggtgcattct tggctcactg caacctccgc     5280

ctcccaggtt caagcaatcc tcccacctca gcctcccaac tagctgggac tgcaggcaca     5340

caccaccatg cctgactaat ttttgtatgt ttagtagaga cggggttttg ccatgttgcc     5400

taggctgggg tttaagttaa attttttaaa aaactaaagt gactggcact aagtgaactt     5460

gagattatcc tcagcttcaa gttcctaaga taagggcttt cttaagcttt caggtgtatg     5520

tatcctctag atgtagacaa taatgtccca tttctaagtc ttttcctttt gcttctcctt     5580

aaattgattg tacttccaaa tttgctgtta tgtttttttc ctaatactgt gatctatctg     5640

atctgcagac aagaaccttg tctctgttga agagcatcaa ggggagatta tgtacacatt     5700

gaaactgaag tgtggtgtta ctgacggaat gtgcagtaac tcctcagata tctgttaagg     5760

catttcccag atgtgatgcc agccttctta cctgtactga aagatgctta gcttagaaaa     5820

aaacaaaaca gatgcaaaat cagataattt tattttgttt catgggtttt cttatttact     5880

ttttaaacaa ggaaggaata ttagaaaatc acacaaggcc tcacatacat gttatttaaa     5940

gaatgaattg ggacggatgt cttagacttc actttcctag gctttttagc aaaacctaaa     6000

gggtggtatc catattttgc gtgaattatg ggtgtaagac cttgcccact taggttttct     6060

atctctgtcc ttgatcttct ttgccaaaat gtgagtatac agaaattttc tgtatatttc     6120

aacttaagac atttttagca tctgtatagt ttgtattcaa tttgagacct tttctatggg     6180

aagctcagta atttttatta aaagattgcc attgctattc atgtaaaaca tggaaaaaaa     6240

ttgtgtagtg aagccaacag tggacttagg atgggattga atgttcagta tagtgatctc     6300

acttaggaga atttgcagga gaaagtgata gtttattgtt ttttcctcgc ccatattcag     6360

ttttgttcta cttcctcccc ttccttccag atgataacat cacatctcta cagtaagtgc     6420

ctctgccagc ccaacccagg agcgcaagtt gtctttgcca tctggtctat agtacagtgc     6480

gcggcgttag gccacaactc aaaagcatta tcttttttag ggttagtaga aattgtttta     6540

tgttgatggg aggtttgttt gattgtcaaa atgtacagcc acagcctttt aatttgggag     6600

cccctgttgt cattcaaatg tgtacctcta cagttgtaaa aagtattaga ttctactatc     6660

tgtgggttgt gcttgccaga caggtcttaa attgtatatt ttttggaaaa gtttatatac     6720

tctcttagga atcattgtga aaagatcaag aaatcaggat ggccatttat ttaatatcca     6780

ttcatttcat gttagtggga ctattaactt gtcaccaagc aggactctat ttcaaacaaa     6840

atttaaaact gtttgtggcc tatatgtgtt taatcctggt taaagataaa gcttcataat     6900

gctgttttta ttcaacacat taaccagctg taaaacacag acctttatca agagtaggca     6960

aagattttca ggattcatat acagatagac tataaagtca tgtaatttga aaagcagtgt     7020

ttcattatga aagagctctc aagttgcttg taaagctaat ctaattaaaa agatgtataa     7080

atgttgttga aacattaaaa aa                                              7102


<210>  6
<211>  4232
<212>  DNA
<213>  Homo sapiens

<400>  6
cgcggggccg tggtgtacgt gcagagcgcg cagagcgagt ggcgcccgta tgccctgcgc       60

tcctccacag cctgggccgg gccgcccggg acgctgaggc ggcggcggcg gccgaggggg      120

ccggtcttgc gctccccagg cccgcgcgcc tgagcccagg ttgccattcg ccgcacaggc      180

cctattctct cagccctcgg cggcgatgag gcgctgaggc ggctgccggc gctgcgccgg      240

agcttaggac tcggaagcgg ccgggccgag ggcgtggggt gccggcctcc ctgaggcgag      300

ggtagcgggt gcatggcgca gtaacggccc ctatctctct ccccgctccc cagcctcggg      360

cgaggccgtc cggccgctac ccctcctgct cggccgccgc agtcgccgtc gccgccgccg      420

ccgccgccat ggccaatgac agcggcgggc ccggcgggcc gagcccgagc gagcgagacc      480

ggcagtactg cgagctgtgc gggaagatgg agaacctgct gcgctgcagc cgctgccgca      540

gctccttcta ctgctgcaag gagcaccagc gtcaggactg gaagaagcac aagctcgtgt      600

gccagggcag cgagggcgcc ctcggccacg gagtgggccc acaccagcat tccggccccg      660

cgccgccggc tgcagtgccg ccgcccaggg ccggggcccg ggagcccagg aaggcagcgg      720

cgcgccggga caacgcctcc ggggacgcgg ccaagggaaa agtaaaggcc aagcccccgg      780

ccgacccagc ggcggccgcg tcgccgtgtc gtgcggccgc cggcggccag ggctcggcgg      840

tggctgccga agccgagccc ggcaaggagg agccgccggc ccgctcatcg ctgttccagg      900

agaaggcgaa cctgtacccc ccaagcaaca cgcccgggga tgcgctgagc cccggcggcg      960

gcctgcggcc caacgggcag acgaagcccc tgccggcgct gaagctggcg ctcgagtaca     1020

tcgtgccgtg catgaacaag cacggcatct gtgtggtgga cgacttcctc ggcaaggaga     1080

ccggacagca gatcggcgac gaggtgcgcg ccctgcacga caccgggaag ttcacggacg     1140

ggcagctggt cagccagaag agtgactcgt ccaaggacat ccgaggcgat aagatcacct     1200

ggatcgaggg caaggagccc ggctgcgaaa ccattgggct gctcatgagc agcatggacg     1260

acctgatacg ccactgtaac gggaagctgg gcagctacaa aatcaatggc cggacgaaag     1320

ccatggttgc ttgttatccg ggcaatggaa cgggttatgt acgtcatgtt gataatccaa     1380

atggagatgg aagatgtgtg acatgtatat attatcttaa taaagactgg gatgccaagg     1440

tacgcaataa ctgtttggta ttttgatgca gatgagagag cacgagctaa agtaaaatat     1500

ctaacaggtg aaaaaggtgt gagggttgaa ctcaataaac cttcagattc ggtcggtaaa     1560

gacgtcttct agagcctttg atccagcaat accccacttc acctacaata ttgttaacta     1620

tttgttaact tgtgaatacg aataaatggg ataaagaaaa atagacaacc agttcgcatt     1680

ttaataagga aacagaaaca actttttgtg ttgcatcaaa cagaagattt tgactgctgt     1740

gactttgtac tgcatgatca acttcaaatc tgtgattgct tacaggagga agataagcta     1800

ctaattgaaa atggttttta catctggata tgaaataagt gccctgtgta gaattttttt     1860

cattcttata ttttgccaga tctgttatct agctgagttc atttcatctc tccctttttt     1920

atatcaagtt tgaatttggg ataatttttc tatattaggt acaatttatc taaactgaat     1980

tgagaaaaaa ttacagtatt attcctcaaa ataacatcaa tctatttttg taaacctgtt     2040

catactatta aattttgccc taaaagacct cttaataatg attgttgcca gtgactgatg     2100

attaatttta ttttacttaa aataagaaaa ggagcacttt aattacaact gaaaaatcag     2160

attgttttgt agtccttcct tacactaatt tgaactgtta aagattgctg cttttttttt     2220

gacattgtca ataacgaaac ctaattgtaa aacagtcacc atttactacc aataactttt     2280

agttaatgtt ttacaaggaa aaagacacaa gaagagttta aatttttttg ttttgttttg     2340

tttttttgag acagtcttgc tctgttaccc aggctggagg ggagtggtgc attcttggct     2400

cactgcaacc tccgcctccc aggttcaagc aatcctccca cctcagcctc ccaactagct     2460

gggactgcag gcacacacca ccatgcctga ctaatttttg tatgtttagt agagacgggg     2520

ttttgccatg ttgcctaggc tggggtttaa gttaaatttt ttaaaaaact aaagtgactg     2580

gcactaagtg aacttgagat tatcctcagc ttcaagttcc taagataagg gctttcttaa     2640

gctttcaggt gtatgtatcc tctagatgta gacaataatg tcccatttct aagtcttttc     2700

cttttgcttc tccttaaatt gattgtactt ccaaatttgc tgttatgttt ttttcctaat     2760

actgtgatct atctgatctg cagacaagaa ccttgtctct gttgaagagc atcaagggga     2820

gattatgtac acattgaaac tgaagtgtgg tgttactgac ggaatgtgca gtaactcctc     2880

agatatctgt taaggcattt cccagatgtg atgccagcct tcttacctgt actgaaagat     2940

gcttagctta gaaaaaaaca aaacagatgc aaaatcagat aattttattt tgtttcatgg     3000

gttttcttat ttacttttta aacaaggaag gaatattaga aaatcacaca aggcctcaca     3060

tacatgttat ttaaagaatg aattgggacg gatgtcttag acttcacttt cctaggcttt     3120

ttagcaaaac ctaaagggtg gtatccatat tttgcgtgaa ttatgggtgt aagaccttgc     3180

ccacttaggt tttctatctc tgtccttgat cttctttgcc aaaatgtgag tatacagaaa     3240

ttttctgtat atttcaactt aagacatttt tagcatctgt atagtttgta ttcaatttga     3300

gaccttttct atgggaagct cagtaatttt tattaaaaga ttgccattgc tattcatgta     3360

aaacatggaa aaaaattgtg tagtgaagcc aacagtggac ttaggatggg attgaatgtt     3420

cagtatagtg atctcactta ggagaatttg caggagaaag tgatagttta ttgttttttc     3480

ctcgcccata ttcagttttg ttctacttcc tccccttcct tccagatgat aacatcacat     3540

ctctacagta agtgcctctg ccagcccaac ccaggagcgc aagttgtctt tgccatctgg     3600

tctatagtac agtgcgcggc gttaggccac aactcaaaag cattatcttt tttagggtta     3660

gtagaaattg ttttatgttg atgggaggtt tgtttgattg tcaaaatgta cagccacagc     3720

cttttaattt gggagcccct gttgtcattc aaatgtgtac ctctacagtt gtaaaaagta     3780

ttagattcta ctatctgtgg gttgtgcttg ccagacaggt cttaaattgt atattttttg     3840

gaaaagttta tatactctct taggaatcat tgtgaaaaga tcaagaaatc aggatggcca     3900

tttatttaat atccattcat ttcatgttag tgggactatt aacttgtcac caagcaggac     3960

tctatttcaa acaaaattta aaactgtttg tggcctatat gtgtttaatc ctggttaaag     4020

ataaagcttc ataatgctgt ttttattcaa cacattaacc agctgtaaaa cacagacctt     4080

tatcaagagt aggcaaagat tttcaggatt catatacaga tagactataa agtcatgtaa     4140

tttgaaaagc agtgtttcat tatgaaagag ctctcaagtt gcttgtaaag ctaatctaat     4200

taaaaagatg tataaatgtt gttgaaacat ta                                   4232


<210>  7
<211>  4301
<212>  DNA
<213>  Homo sapiens

<400>  7
cgcggggccg tggtgtacgt gcagagcgcg cagagcgagt ggcgcccgta tgccctgcgc       60

tcctccacag cctgggccgg gccgcccggg acgctgaggc ggcggcggcg gccgaggggg      120

ccggtcttgc gctccccagg cccgcgcgcc tgagcccagg ttgccattcg ccgcacaggc      180

cctattctct cagccctcgg cggcgatgag gcgctgaggc ggctgccggc gctgcgccgg      240

agcttaggac tcggaagcgg ccgggccgag ggcgtggggt gccggcctcc ctgaggcgag      300

ggtagcgggt gcatggcgca gtaacggccc ctatctctct ccccgctccc cagcctcggg      360

cgaggccgtc cggccgctac ccctcctgct cggccgccgc agtcgccgtc gccgccgccg      420

ccgccgccat ggccaatgac agcggcgggc ccggcgggcc gagcccgagc gagcgagacc      480

ggcagtactg cgagctgtgc gggaagatgg agaacctgct gcgctgcagc cgctgccgca      540

gctccttcta ctgctgcaag gagcaccagc gtcaggactg gaagaagcac aagctcgtgt      600

gccagggcag cgagggcgcc ctcggccacg gagtgggccc acaccagcat tccggccccg      660

cgccgccggc tgcagtgccg ccgcccaggg ccggggcccg ggagcccagg aaggcagcgg      720

cgcgccggga caacgcctcc ggggacgcgg ccaagggaaa agtaaaggcc aagcccccgg      780

ccgacccagc ggcggccgcg tcgccgtgtc gtgcggccgc cggcggccag ggctcggcgg      840

tggctgccga agccgagccc ggcaaggagg agccgccggc ccgctcatcg ctgttccagg      900

agaaggcgaa cctgtacccc ccaagcaaca cgcccgggga tgcgctgagc cccggcggcg      960

gcctgcggcc caacgggcag acgaagcccc tgccggcgct gaagctggcg ctcgagtaca     1020

tcgtgccgtg catgaacaag cacggcatct gtgtggtgga cgacttcctc ggcaaggaga     1080

ccggacagca gatcggcgac gaggtgcgcg ccctgcacga caccgggaag ttcacggacg     1140

ggcagctggt cagccagaag agtgactcgt ccaaggacat ccgaggcgat aagatcacct     1200

ggatcgaggg caaggagccc ggctgcgaaa ccattgggct gctcatgagc agcatggacg     1260

acctgatacg ccactgtaac gggaagctgg gcagctacaa aatcaatggc cggacgaaag     1320

ccatggttgc ttgttatccg ggcaatggaa cgggttatgt acgtcatgtt gataatccaa     1380

atggagatgg aagatgtgtg acatgtatat attatcttaa taaagactgg gatgccaagg     1440

taagtggagg tatacttcga atttttccag aaggcaaagc ccagtttgct gacattgaac     1500

ccaaatttga tagactgctg tttttctggt ctgaccgtcg caaccctcat gaagtacaac     1560

cagcatatgc tacaaggtga aaaaggtgtg agggttgaac tcaataaacc ttcagattcg     1620

gtcggtaaag acgtcttcta gagcctttga tccagcaata ccccacttca cctacaatat     1680

tgttaactat ttgttaactt gtgaatacga ataaatggga taaagaaaaa tagacaacca     1740

gttcgcattt taataaggaa acagaaacaa ctttttgtgt tgcatcaaac agaagatttt     1800

gactgctgtg actttgtact gcatgatcaa cttcaaatct gtgattgctt acaggaggaa     1860

gataagctac taattgaaaa tggtttttac atctggatat gaaataagtg ccctgtgtag     1920

aatttttttc attcttatat tttgccagat ctgttatcta gctgagttca tttcatctct     1980

ccctttttta tatcaagttt gaatttggga taatttttct atattaggta caatttatct     2040

aaactgaatt gagaaaaaat tacagtatta ttcctcaaaa taacatcaat ctatttttgt     2100

aaacctgttc atactattaa attttgccct aaaagacctc ttaataatga ttgttgccag     2160

tgactgatga ttaattttat tttacttaaa ataagaaaag gagcacttta attacaactg     2220

aaaaatcaga ttgttttgta gtccttcctt acactaattt gaactgttaa agattgctgc     2280

tttttttttg acattgtcaa taacgaaacc taattgtaaa acagtcacca tttactacca     2340

ataactttta gttaatgttt tacaaggaaa aagacacaag aagagtttaa atttttttgt     2400

tttgttttgt ttttttgaga cagtcttgct ctgttaccca ggctggaggg gagtggtgca     2460

ttcttggctc actgcaacct ccgcctccca ggttcaagca atcctcccac ctcagcctcc     2520

caactagctg ggactgcagg cacacaccac catgcctgac taatttttgt atgtttagta     2580

gagacggggt tttgccatgt tgcctaggct ggggtttaag ttaaattttt taaaaaacta     2640

aagtgactgg cactaagtga acttgagatt atcctcagct tcaagttcct aagataaggg     2700

ctttcttaag ctttcaggtg tatgtatcct ctagatgtag acaataatgt cccatttcta     2760

agtcttttcc ttttgcttct ccttaaattg attgtacttc caaatttgct gttatgtttt     2820

tttcctaata ctgtgatcta tctgatctgc agacaagaac cttgtctctg ttgaagagca     2880

tcaaggggag attatgtaca cattgaaact gaagtgtggt gttactgacg gaatgtgcag     2940

taactcctca gatatctgtt aaggcatttc ccagatgtga tgccagcctt cttacctgta     3000

ctgaaagatg cttagcttag aaaaaaacaa aacagatgca aaatcagata attttatttt     3060

gtttcatggg ttttcttatt tactttttaa acaaggaagg aatattagaa aatcacacaa     3120

ggcctcacat acatgttatt taaagaatga attgggacgg atgtcttaga cttcactttc     3180

ctaggctttt tagcaaaacc taaagggtgg tatccatatt ttgcgtgaat tatgggtgta     3240

agaccttgcc cacttaggtt ttctatctct gtccttgatc ttctttgcca aaatgtgagt     3300

atacagaaat tttctgtata tttcaactta agacattttt agcatctgta tagtttgtat     3360

tcaatttgag accttttcta tgggaagctc agtaattttt attaaaagat tgccattgct     3420

attcatgtaa aacatggaaa aaaattgtgt agtgaagcca acagtggact taggatggga     3480

ttgaatgttc agtatagtga tctcacttag gagaatttgc aggagaaagt gatagtttat     3540

tgttttttcc tcgcccatat tcagttttgt tctacttcct ccccttcctt ccagatgata     3600

acatcacatc tctacagtaa gtgcctctgc cagcccaacc caggagcgca agttgtcttt     3660

gccatctggt ctatagtaca gtgcgcggcg ttaggccaca actcaaaagc attatctttt     3720

ttagggttag tagaaattgt tttatgttga tgggaggttt gtttgattgt caaaatgtac     3780

agccacagcc ttttaatttg ggagcccctg ttgtcattca aatgtgtacc tctacagttg     3840

taaaaagtat tagattctac tatctgtggg ttgtgcttgc cagacaggtc ttaaattgta     3900

tattttttgg aaaagtttat atactctctt aggaatcatt gtgaaaagat caagaaatca     3960

ggatggccat ttatttaata tccattcatt tcatgttagt gggactatta acttgtcacc     4020

aagcaggact ctatttcaaa caaaatttaa aactgtttgt ggcctatatg tgtttaatcc     4080

tggttaaaga taaagcttca taatgctgtt tttattcaac acattaacca gctgtaaaac     4140

acagaccttt atcaagagta ggcaaagatt ttcaggattc atatacagat agactataaa     4200

gtcatgtaat ttgaaaagca gtgtttcatt atgaaagagc tctcaagttg cttgtaaagc     4260

taatctaatt aaaaagatgt ataaatgttg ttgaaacatt a                         4301


<210>  8
<211>  426
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Ala Asn Asp Ser Gly Gly Pro Gly Gly Pro Ser Pro Ser Glu Arg 
1               5                   10                  15      


Asp Arg Gln Tyr Cys Glu Leu Cys Gly Lys Met Glu Asn Leu Leu Arg 
            20                  25                  30          


Cys Ser Arg Cys Arg Ser Ser Phe Tyr Cys Cys Lys Glu His Gln Arg 
        35                  40                  45              


Gln Asp Trp Lys Lys His Lys Leu Val Cys Gln Gly Ser Glu Gly Ala 
    50                  55                  60                  


Leu Gly His Gly Val Gly Pro His Gln His Ser Gly Pro Ala Pro Pro 
65                  70                  75                  80  


Ala Ala Val Pro Pro Pro Arg Ala Gly Ala Arg Glu Pro Arg Lys Ala 
                85                  90                  95      


Ala Ala Arg Arg Asp Asn Ala Ser Gly Asp Ala Ala Lys Gly Lys Val 
            100                 105                 110         


Lys Ala Lys Pro Pro Ala Asp Pro Ala Ala Ala Ala Ser Pro Cys Arg 
        115                 120                 125             


Ala Ala Ala Gly Gly Gln Gly Ser Ala Val Ala Ala Glu Ala Glu Pro 
    130                 135                 140                 


Gly Lys Glu Glu Pro Pro Ala Arg Ser Ser Leu Phe Gln Glu Lys Ala 
145                 150                 155                 160 


Asn Leu Tyr Pro Pro Ser Asn Thr Pro Gly Asp Ala Leu Ser Pro Gly 
                165                 170                 175     


Gly Gly Leu Arg Pro Asn Gly Gln Thr Lys Pro Leu Pro Ala Leu Lys 
            180                 185                 190         


Leu Ala Leu Glu Tyr Ile Val Pro Cys Met Asn Lys His Gly Ile Cys 
        195                 200                 205             


Val Val Asp Asp Phe Leu Gly Lys Glu Thr Gly Gln Gln Ile Gly Asp 
    210                 215                 220                 


Glu Val Arg Ala Leu His Asp Thr Gly Lys Phe Thr Asp Gly Gln Leu 
225                 230                 235                 240 


Val Ser Gln Lys Ser Asp Ser Ser Lys Asp Ile Arg Gly Asp Lys Ile 
                245                 250                 255     


Thr Trp Ile Glu Gly Lys Glu Pro Gly Cys Glu Thr Ile Gly Leu Leu 
            260                 265                 270         


Met Ser Ser Met Asp Asp Leu Ile Arg His Cys Asn Gly Lys Leu Gly 
        275                 280                 285             


Ser Tyr Lys Ile Asn Gly Arg Thr Lys Ala Met Val Ala Cys Tyr Pro 
    290                 295                 300                 


Gly Asn Gly Thr Gly Tyr Val Arg His Val Asp Asn Pro Asn Gly Asp 
305                 310                 315                 320 


Gly Arg Cys Val Thr Cys Ile Tyr Tyr Leu Asn Lys Asp Trp Asp Ala 
                325                 330                 335     


Lys Val Ser Gly Gly Ile Leu Arg Ile Phe Pro Glu Gly Lys Ala Gln 
            340                 345                 350         


Phe Ala Asp Ile Glu Pro Lys Phe Asp Arg Leu Leu Phe Phe Trp Ser 
        355                 360                 365             


Asp Arg Arg Asn Pro His Glu Val Gln Pro Ala Tyr Ala Thr Arg Tyr 
    370                 375                 380                 


Ala Ile Thr Val Trp Tyr Phe Asp Ala Asp Glu Arg Ala Arg Ala Lys 
385                 390                 395                 400 


Val Lys Tyr Leu Thr Gly Glu Lys Gly Val Arg Val Glu Leu Asn Lys 
                405                 410                 415     


Pro Ser Asp Ser Val Gly Lys Asp Val Phe 
            420                 425     


<210>  9
<211>  345
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Ala Asn Asp Ser Gly Gly Pro Gly Gly Pro Ser Pro Ser Glu Arg 
1               5                   10                  15      


Asp Arg Gln Tyr Cys Glu Leu Cys Gly Lys Met Glu Asn Leu Leu Arg 
            20                  25                  30          


Cys Ser Arg Cys Arg Ser Ser Phe Tyr Cys Cys Lys Glu His Gln Arg 
        35                  40                  45              


Gln Asp Trp Lys Lys His Lys Leu Val Cys Gln Gly Ser Glu Gly Ala 
    50                  55                  60                  


Leu Gly His Gly Val Gly Pro His Gln His Ser Gly Pro Ala Pro Pro 
65                  70                  75                  80  


Ala Ala Val Pro Pro Pro Arg Ala Gly Ala Arg Glu Pro Arg Lys Ala 
                85                  90                  95      


Ala Ala Arg Arg Asp Asn Ala Ser Gly Asp Ala Ala Lys Gly Lys Val 
            100                 105                 110         


Lys Ala Lys Pro Pro Ala Asp Pro Ala Ala Ala Ala Ser Pro Cys Arg 
        115                 120                 125             


Ala Ala Ala Gly Gly Gln Gly Ser Ala Val Ala Ala Glu Ala Glu Pro 
    130                 135                 140                 


Gly Lys Glu Glu Pro Pro Ala Arg Ser Ser Leu Phe Gln Glu Lys Ala 
145                 150                 155                 160 


Asn Leu Tyr Pro Pro Ser Asn Thr Pro Gly Asp Ala Leu Ser Pro Gly 
                165                 170                 175     


Gly Gly Leu Arg Pro Asn Gly Gln Thr Lys Pro Leu Pro Ala Leu Lys 
            180                 185                 190         


Leu Ala Leu Glu Tyr Ile Val Pro Cys Met Asn Lys His Gly Ile Cys 
        195                 200                 205             


Val Val Asp Asp Phe Leu Gly Lys Glu Thr Gly Gln Gln Ile Gly Asp 
    210                 215                 220                 


Glu Val Arg Ala Leu His Asp Thr Gly Lys Phe Thr Asp Gly Gln Leu 
225                 230                 235                 240 


Val Ser Gln Lys Ser Asp Ser Ser Lys Asp Ile Arg Gly Asp Lys Ile 
                245                 250                 255     


Thr Trp Ile Glu Gly Lys Glu Pro Gly Cys Glu Thr Ile Gly Leu Leu 
            260                 265                 270         


Met Ser Ser Met Asp Asp Leu Ile Arg His Cys Asn Gly Lys Leu Gly 
        275                 280                 285             


Ser Tyr Lys Ile Asn Gly Arg Thr Lys Ala Met Val Ala Cys Tyr Pro 
    290                 295                 300                 


Gly Asn Gly Thr Gly Tyr Val Arg His Val Asp Asn Pro Asn Gly Asp 
305                 310                 315                 320 


Gly Arg Cys Val Thr Cys Ile Tyr Tyr Leu Asn Lys Asp Trp Asp Ala 
                325                 330                 335     


Lys Val Arg Asn Asn Cys Leu Val Phe 
            340                 345 


<210>  10
<211>  383
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Ala Asn Asp Ser Gly Gly Pro Gly Gly Pro Ser Pro Ser Glu Arg 
1               5                   10                  15      


Asp Arg Gln Tyr Cys Glu Leu Cys Gly Lys Met Glu Asn Leu Leu Arg 
            20                  25                  30          


Cys Ser Arg Cys Arg Ser Ser Phe Tyr Cys Cys Lys Glu His Gln Arg 
        35                  40                  45              


Gln Asp Trp Lys Lys His Lys Leu Val Cys Gln Gly Ser Glu Gly Ala 
    50                  55                  60                  


Leu Gly His Gly Val Gly Pro His Gln His Ser Gly Pro Ala Pro Pro 
65                  70                  75                  80  


Ala Ala Val Pro Pro Pro Arg Ala Gly Ala Arg Glu Pro Arg Lys Ala 
                85                  90                  95      


Ala Ala Arg Arg Asp Asn Ala Ser Gly Asp Ala Ala Lys Gly Lys Val 
            100                 105                 110         


Lys Ala Lys Pro Pro Ala Asp Pro Ala Ala Ala Ala Ser Pro Cys Arg 
        115                 120                 125             


Ala Ala Ala Gly Gly Gln Gly Ser Ala Val Ala Ala Glu Ala Glu Pro 
    130                 135                 140                 


Gly Lys Glu Glu Pro Pro Ala Arg Ser Ser Leu Phe Gln Glu Lys Ala 
145                 150                 155                 160 


Asn Leu Tyr Pro Pro Ser Asn Thr Pro Gly Asp Ala Leu Ser Pro Gly 
                165                 170                 175     


Gly Gly Leu Arg Pro Asn Gly Gln Thr Lys Pro Leu Pro Ala Leu Lys 
            180                 185                 190         


Leu Ala Leu Glu Tyr Ile Val Pro Cys Met Asn Lys His Gly Ile Cys 
        195                 200                 205             


Val Val Asp Asp Phe Leu Gly Lys Glu Thr Gly Gln Gln Ile Gly Asp 
    210                 215                 220                 


Glu Val Arg Ala Leu His Asp Thr Gly Lys Phe Thr Asp Gly Gln Leu 
225                 230                 235                 240 


Val Ser Gln Lys Ser Asp Ser Ser Lys Asp Ile Arg Gly Asp Lys Ile 
                245                 250                 255     


Thr Trp Ile Glu Gly Lys Glu Pro Gly Cys Glu Thr Ile Gly Leu Leu 
            260                 265                 270         


Met Ser Ser Met Asp Asp Leu Ile Arg His Cys Asn Gly Lys Leu Gly 
        275                 280                 285             


Ser Tyr Lys Ile Asn Gly Arg Thr Lys Ala Met Val Ala Cys Tyr Pro 
    290                 295                 300                 


Gly Asn Gly Thr Gly Tyr Val Arg His Val Asp Asn Pro Asn Gly Asp 
305                 310                 315                 320 


Gly Arg Cys Val Thr Cys Ile Tyr Tyr Leu Asn Lys Asp Trp Asp Ala 
                325                 330                 335     


Lys Val Ser Gly Gly Ile Leu Arg Ile Phe Pro Glu Gly Lys Ala Gln 
            340                 345                 350         


Phe Ala Asp Ile Glu Pro Lys Phe Asp Arg Leu Leu Phe Phe Trp Ser 
        355                 360                 365             


Asp Arg Arg Asn Pro His Glu Val Gln Pro Ala Tyr Ala Thr Arg 
    370                 375                 380             


<210>  11
<211>  2199
<212>  DNA
<213>  Homo sapiens

<400>  11
ggcttcgcgc tcgtgtagat cgttccctct ctggttgcac gctggggatc ccggacctcg       60

attctgcggg cgagatgccc ctgggacaca tcatgaggct ggacctggag aaaattgccc      120

tggagtacat cgtgccctgt ctgcacgagg caatggtggc ttgctatccg ggaaatggaa      180

caggttatgt tcgccacgtg gacaacccca acggtgatgg tcgctgcatc acctgcatct      240

actatctgaa caagaattgg gatgccaagc tacatggtgg gatcctgcgg atatttccag      300

aggggaaatc attcatagca gatgtggagc ccatttttga cagactcctg ttcttctggt      360

cagatcgtag gaacccacac gaagtgcagc cctcttacgc aaccagatat gctatgactg      420

tctggtactt tgatgctgaa gaaagggcag aagccaaaaa gaaattcagg aatttaacta      480

ggaaaactga atctgccctc actgaagact gaccgtgctc tgaaatctgc tggccttgtt      540

cattttagta acggttcctg aattctctta aattctttga gatccaaaga tggcctcttc      600

agtgacaaca atctccctgc tacttcttgc atccttcaca tccctgtctt gtgtgtggta      660

cttcatgttt tcttgccaag actgtgttga tcttcagata ctctctttgc cagatgaagt      720

tacttgctaa ctccagaaat tcctgcagac atcctactcg gccagcggtt tacctgatag      780

attcggtaat actatcaaga gaagagccta ggagcacagc gagggaatga accttacttg      840

cactttatgt atacttcctg atttgaaagg aggaggtttg aaaagaaaaa aatggaggtg      900

gtagatgcca cagagaggca tcacggaagc cttaacagca ggaaacagag aaatttgtgt      960

catctgaaca atttccagat gttcttaatc cagggctgtt ggggtttctg gagaattatc     1020

acaacctaat gacattaata cctctagaaa gggctgctgt catagtgaac aatttataag     1080

tgtcccatgg ggcagacact ccttttttcc cagtcctgca acctggattt tctgcctcag     1140

ccccattttg ctgaaaataa tgactttctg aataaagatg gcaacacaat tttttctcca     1200

ttttcagttc ttacctggga acctaattcc ccagaagcta aaaaactaga cattagttgt     1260

tttggttgct ttgttggaat ggaatttaaa tttaaatgaa aggaaaaata tatccctggt     1320

agttttgtgt taaccactga taactgtgga aagagctagg tctactgata tacaataaac     1380

atgtgtgcat cttgaacaat ttgagagggg aggtggagtt ggaaatgtgg gtgttcctgt     1440

tttttttttt tttttttttt tagttttcct ttttaatgag ctcacccttt aacacaaaaa     1500

aagcaaggtg atgtatttta aaaaaggaag tggaaataaa aaaatctcaa agctatttga     1560

gttctcgtct gtccctagca gtctttcttc agctcacttg gctctctaga tccactgtgg     1620

ttggcagtat gaccagaatc atggaatttg ctagaactgt ggaagcttct actcctgcag     1680

taagcacaga tcgcactgcc tcaataactt ggtattgagc acgtattttg caaaagctac     1740

ttttcctagt tttcagtatt actttcatgt tttaaaaatc cctttaattt cttgcttgaa     1800

aatcccatga acattaaaga gccagaaata ttttcctttg ttatgtacgg atatatatat     1860

atatagtctt ccaagataga agtttacttt ttcctcttct ggttttggaa aatttccaga     1920

taagacatgt caccattaat tctcaacgac tgctctattt tgttgtacgg taatagttat     1980

caccttctaa attactatgt aatttattca cttattatgt ttattgtctt gtatcctttc     2040

tctggagtgt aagcacaatg aagacaggaa ttttgtatat ttttaaccaa tgcaacatac     2100

tctcagcacc taaaatagtg ccgggaacat agtaagggct cagtaaatac ttgttgaata     2160

aactcagtct cctacattag cattctaaaa aaaaaaaaa                            2199


<210>  12
<211>  2722
<212>  DNA
<213>  Homo sapiens

<400>  12
gagtctggcc gcagtcgcgg cagtggtggc ttcccatccc caaaaggcgc cctccgactc       60

cttgcgccgc actgctcgcc gggccagtcc ggaaacgggt cgtggagctc cgcaccactc      120

ccgctggttc ccgaaggcag atcccttctc ccgagagttg cgagaaactt tcccttgtcc      180

ccgacgctgc agcggctcgg gtaccgtggc agccgcaggt ttctgaaccc cgggccacgc      240

tccccgcgcc tcggcttcgc gctcgtgtag atcgttccct ctctggttgc acgctgggga      300

tcccggacct cgattctgcg ggcgagatgc ccctgggaca catcatgagg ctggacctgg      360

agaaaattgc cctggagtac atcgtgccct gtctgcacga ggtgggcttc tgctacctgg      420

acaacttcct gggcgaggtg gtgggcgact gcgtcctgga gcgcgtcaag cagctgcact      480

gcaccggggc cctgcgggac ggccagctgg cggggccgcg cgccggcgtc tccaagcgac      540

acctgcgggg cgaccagatc acgtggatcg ggggcaacga ggagggctgc gaggccatca      600

gcttcctcct gtccctcatc gacaggctgg tcctctactg cgggagccgg ctgggcaaat      660

actacgtcaa ggagaggtct aaggcaatgg tggcttgcta tccgggaaat ggaacaggtt      720

atgttcgcca cgtggacaac cccaacggtg atggtcgctg catcacctgc atctactatc      780

tgaacaagaa ttgggatgcc aagctacatg gtgggatcct gcggatattt ccagagggga      840

aatcattcat agcagatgtg gagcccattt ttgacagact cctgttcttc tggtcagatc      900

gtaggaaccc acacgaagtg cagccctctt acgcaaccag atatgctatg actgtctggt      960

actttgatgc tgaagaaagg gcagaagcca aaaagaaatt caggaattta actaggaaaa     1020

ctgaatctgc cctcactgaa gactgaccgt gctctgaaat ctgctggcct tgttcatttt     1080

agtaacggtt cctgaattct cttaaattct ttgagatcca aagatggcct cttcagtgac     1140

aacaatctcc ctgctacttc ttgcatcctt cacatccctg tcttgtgtgt ggtacttcat     1200

gttttcttgc caagactgtg ttgatcttca gatactctct ttgccagatg aagttacttg     1260

ctaactccag aaattcctgc agacatccta ctcggccagc ggtttacctg atagattcgg     1320

taatactatc aagagaagag cctaggagca cagcgaggga atgaacctta cttgcacttt     1380

atgtatactt cctgatttga aaggaggagg tttgaaaaga aaaaaatgga ggtggtagat     1440

gccacagaga ggcatcacgg aagccttaac agcaggaaac agagaaattt gtgtcatctg     1500

aacaatttcc agatgttctt aatccagggc tgttggggtt tctggagaat tatcacaacc     1560

taatgacatt aatacctcta gaaagggctg ctgtcatagt gaacaattta taagtgtccc     1620

atggggcaga cactcctttt ttcccagtcc tgcaacctgg attttctgcc tcagccccat     1680

tttgctgaaa ataatgactt tctgaataaa gatggcaaca caattttttc tccattttca     1740

gttcttacct gggaacctaa ttccccagaa gctaaaaaac tagacattag ttgttttggt     1800

tgctttgttg gaatggaatt taaatttaaa tgaaaggaaa aatatatccc tggtagtttt     1860

gtgttaacca ctgataactg tggaaagagc taggtctact gatatacaat aaacatgtgt     1920

gcatcttgaa caatttgaga ggggaggtgg agttggaaat gtgggtgttc ctgttttttt     1980

tttttttttt tttttagttt tcctttttaa tgagctcacc ctttaacaca aaaaaagcaa     2040

ggtgatgtat tttaaaaaag gaagtggaaa taaaaaaatc tcaaagctat ttgagttctc     2100

gtctgtccct agcagtcttt cttcagctca cttggctctc tagatccact gtggttggca     2160

gtatgaccag aatcatggaa tttgctagaa ctgtggaagc ttctactcct gcagtaagca     2220

cagatcgcac tgcctcaata acttggtatt gagcacgtat tttgcaaaag ctacttttcc     2280

tagttttcag tattactttc atgttttaaa aatcccttta atttcttgct tgaaaatccc     2340

atgaacatta aagagccaga aatattttcc tttgttatgt acggatatat atatatatag     2400

tcttccaaga tagaagttta ctttttcctc ttctggtttt ggaaaatttc cagataagac     2460

atgtcaccat taattctcaa cgactgctct attttgttgt acggtaatag ttatcacctt     2520

ctaaattact atgtaattta ttcacttatt atgtttattg tcttgtatcc tttctctgga     2580

gtgtaagcac aatgaagaca ggaattttgt atatttttaa ccaatgcaac atactctcag     2640

cacctaaaat agtgccggga acatagtaag ggctcagtaa atacttgttg aataaactca     2700

gtctcctaca ttagcattct aa                                              2722


<210>  13
<211>  145
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Pro Leu Gly His Ile Met Arg Leu Asp Leu Glu Lys Ile Ala Leu 
1               5                   10                  15      


Glu Tyr Ile Val Pro Cys Leu His Glu Ala Met Val Ala Cys Tyr Pro 
            20                  25                  30          


Gly Asn Gly Thr Gly Tyr Val Arg His Val Asp Asn Pro Asn Gly Asp 
        35                  40                  45              


Gly Arg Cys Ile Thr Cys Ile Tyr Tyr Leu Asn Lys Asn Trp Asp Ala 
    50                  55                  60                  


Lys Leu His Gly Gly Ile Leu Arg Ile Phe Pro Glu Gly Lys Ser Phe 
65                  70                  75                  80  


Ile Ala Asp Val Glu Pro Ile Phe Asp Arg Leu Leu Phe Phe Trp Ser 
                85                  90                  95      


Asp Arg Arg Asn Pro His Glu Val Gln Pro Ser Tyr Ala Thr Arg Tyr 
            100                 105                 110         


Ala Met Thr Val Trp Tyr Phe Asp Ala Glu Glu Arg Ala Glu Ala Lys 
        115                 120                 125             


Lys Lys Phe Arg Asn Leu Thr Arg Lys Thr Glu Ser Ala Leu Thr Glu 
    130                 135                 140                 


Asp 
145 


<210>  14
<211>  239
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Pro Leu Gly His Ile Met Arg Leu Asp Leu Glu Lys Ile Ala Leu 
1               5                   10                  15      


Glu Tyr Ile Val Pro Cys Leu His Glu Val Gly Phe Cys Tyr Leu Asp 
            20                  25                  30          


Asn Phe Leu Gly Glu Val Val Gly Asp Cys Val Leu Glu Arg Val Lys 
        35                  40                  45              


Gln Leu His Cys Thr Gly Ala Leu Arg Asp Gly Gln Leu Ala Gly Pro 
    50                  55                  60                  


Arg Ala Gly Val Ser Lys Arg His Leu Arg Gly Asp Gln Ile Thr Trp 
65                  70                  75                  80  


Ile Gly Gly Asn Glu Glu Gly Cys Glu Ala Ile Ser Phe Leu Leu Ser 
                85                  90                  95      


Leu Ile Asp Arg Leu Val Leu Tyr Cys Gly Ser Arg Leu Gly Lys Tyr 
            100                 105                 110         


Tyr Val Lys Glu Arg Ser Lys Ala Met Val Ala Cys Tyr Pro Gly Asn 
        115                 120                 125             


Gly Thr Gly Tyr Val Arg His Val Asp Asn Pro Asn Gly Asp Gly Arg 
    130                 135                 140                 


Cys Ile Thr Cys Ile Tyr Tyr Leu Asn Lys Asn Trp Asp Ala Lys Leu 
145                 150                 155                 160 


His Gly Gly Ile Leu Arg Ile Phe Pro Glu Gly Lys Ser Phe Ile Ala 
                165                 170                 175     


Asp Val Glu Pro Ile Phe Asp Arg Leu Leu Phe Phe Trp Ser Asp Arg 
            180                 185                 190         


Arg Asn Pro His Glu Val Gln Pro Ser Tyr Ala Thr Arg Tyr Ala Met 
        195                 200                 205             


Thr Val Trp Tyr Phe Asp Ala Glu Glu Arg Ala Glu Ala Lys Lys Lys 
    210                 215                 220                 


Phe Arg Asn Leu Thr Arg Lys Thr Glu Ser Ala Leu Thr Glu Asp 
225                 230                 235                 


