                         SEQUENCE LISTING

<110>  Carmel-Haifa University Economic Corporation Ltd.
 
<120>  APOPTOSIS RELATED PROTEIN IN THE TGF-BETA SIGNALING PATHWAY 
       (ARTS) MIMETIC COMPOUNDS, COMPOSITIONS, METHODS AND USES THEREOF 
       IN INDUCTION OF DIFFERENTIATION AND/OR APOPTOSIS  OF PREMALIGNANT AND MALIGNANT 
       CELLS, THEREBY RESTORING THEIR NORMAL-LIKE PHENOTYPE

<130>  2448042

<150>  US 62/249/446
<151>  2015-11-02

<160>  27    

<170>  PatentIn version 3.5

<210>  1
<211>  274
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ile Lys Arg Phe Leu Glu Asp Thr Thr Asp Asp Gly Glu Leu Ser 
1               5                   10                  15      


Lys Phe Val Lys Asp Phe Ser Gly Asn Ala Ser Cys His Pro Pro Glu 
            20                  25                  30          


Ala Lys Thr Trp Ala Ser Arg Pro Gln Val Pro Glu Pro Arg Pro Gln 
        35                  40                  45              


Ala Pro Asp Leu Tyr Asp Asp Asp Leu Glu Phe Arg Pro Pro Ser Arg 
    50                  55                  60                  


Pro Gln Ser Ser Asp Asn Gln Gln Tyr Phe Cys Ala Pro Ala Pro Leu 
65                  70                  75                  80  


Ser Pro Ser Ala Arg Pro Arg Ser Pro Trp Gly Lys Leu Asp Pro Tyr 
                85                  90                  95      


Asp Ser Ser Glu Asp Asp Lys Glu Tyr Val Gly Phe Ala Thr Leu Pro 
            100                 105                 110         


Asn Gln Val His Arg Lys Ser Val Lys Lys Gly Phe Asp Phe Thr Leu 
        115                 120                 125             


Met Val Ala Gly Glu Ser Gly Leu Gly Lys Ser Thr Leu Val Asn Ser 
    130                 135                 140                 


Leu Phe Leu Thr Asp Leu Tyr Arg Asp Arg Lys Leu Leu Gly Ala Glu 
145                 150                 155                 160 


Glu Arg Ile Met Gln Thr Val Glu Ile Thr Lys His Ala Val Asp Ile 
                165                 170                 175     


Glu Glu Lys Gly Val Arg Leu Arg Leu Thr Ile Val Asp Thr Pro Gly 
            180                 185                 190         


Phe Gly Asp Ala Val Asn Asn Thr Glu Cys Trp Lys Pro Val Ala Glu 
        195                 200                 205             


Tyr Ile Asp Gln Gln Phe Glu Gln Tyr Phe Arg Asp Glu Ser Gly Leu 
    210                 215                 220                 


Asn Arg Lys Asn Ile Gln Asp Asn Arg Val His Cys Cys Leu Tyr Phe 
225                 230                 235                 240 


Ile Ser Pro Phe Gly His Gly Tyr Gly Pro Ser Leu Arg Leu Leu Ala 
                245                 250                 255     


Pro Pro Gly Ala Val Lys Gly Thr Gly Gln Glu His Gln Gly Gln Gly 
            260                 265                 270         


Cys His 
        


<210>  2
<211>  1911
<212>  DNA
<213>  Homo sapiens

<400>  2
cggcggtgct gcgaggtcgg cgcgcacgtc cgccgcgggt cgctcgggcg ctgtccaggc       60

ggagccggcc ccgcccgggc tgcagccatg atcaagcgtt tcctggagga caccacggat      120

gatggagaac tgagcaagtt cgtgaaggat ttctcaggaa atgcgagctg ccacccacca      180

gaggctaaga cctgggcatc caggccccaa gtcccggagc caaggcccca ggccccggac      240

ctctatgatg atgacctgga gttcagaccc ccctcgcggc cccagtcctc tgacaaccag      300

cagtacttct gtgccccagc ccctctcagc ccatctgcca ggccccgcag cccatggggc      360

aagcttgatc cctatgattc ctctgaggat gacaaggagt atgtgggctt tgcaaccctc      420

cccaaccaag tccaccgaaa gtccgtgaag aaaggctttg actttaccct catggtggca      480

ggagagtctg gcctgggcaa atccacactt gtcaatagcc tcttcctcac tgatctgtac      540

cgggaccgga aacttcttgg tgctgaagag aggatcatgc aaactgtgga gatcactaag      600

catgcagtgg acatagaaga gaagggtgtg aggctgcggc tcaccattgt ggacacacca      660

ggttttgggg atgcagtcaa caacacagag tgctggaagc ctgtggcaga atacattgat      720

cagcagtttg agcagtattt ccgagacgag agtggcctga accgaaagaa catccaagac      780

aacagggtgc actgctgcct gtacttcatc tcacccttcg gccatgggta tggtccaagc      840

ctgaggctcc tggcaccacc gggtgctgtc aagggaacag gccaagagca ccaggggcag      900

ggctgccact agcaggtggt cacaggttcc tgttccccag gctccggcca ttggatgttg      960

aattcatgaa ggccctgcat cagcgggtca acatcgtgcc tatcctggct aaggcagaca     1020

cactgacacc tcccgaagtg gaccacaaga aacgcaaaat ccgggaggag attgagcatt     1080

ttggaatcaa gatctatcaa ttcccagact gtgactctga tgaggatgag gacttcaaat     1140

tgcaggacca agccctaaag gaaagcatcc catttgcagt aattggcagc aacactgtag     1200

tagaggccag agggcggcga gttcggggtc gactctaccc ctggggcatc gtggaagtgg     1260

aaaacccagg gcactgcgac tttgtgaagc tgaggacaat gctggtacgt acccacatgc     1320

aggacctgaa ggatgtgaca cgggagacac attatgagaa ctaccgggca cagtgcatcc     1380

agagcatgac ccgcctggtg gtgaaggaac ggaatcgcaa gtatgaccag aagccaggac     1440

aaagctggca gggggagatc ccaagcctag ccttgggtga gaccaagccc tacttttgtt     1500

cttctatagg ccctgggctc aatctaagcg ggtgctgggg tcctcctcgc cttatcaacc     1560

cttttctccc tttagcaaac tgactcggga aagtggtacc gacttcccca tccctgctgt     1620

cccaccaggg acagatccag aaactgagaa gcttatccga gagaaagatg aggagctgcg     1680

gcggatgcag gagatgctac acaaaataca aaaacagatg aaggagaact attaactggc     1740

tttcagccct ggatatttaa atctcctcct cttcttcctg tccatgccgg cccctcccag     1800

caccagctct gctcaggccc cttcagctac tgccacttcg ccttacatcc ctgctgactg     1860

cccagagact cagaggaaat aaagtttaat aaatctgtag gtggctaaaa a              1911


<210>  3
<211>  239
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Ala His Ala Gly Arg Thr Gly Tyr Asp Asn Arg Glu Ile Val Met 
1               5                   10                  15      


Lys Tyr Ile His Tyr Lys Leu Ser Gln Arg Gly Tyr Glu Trp Asp Ala 
            20                  25                  30          


Gly Asp Val Gly Ala Ala Pro Pro Gly Ala Ala Pro Ala Pro Gly Ile 
        35                  40                  45              


Phe Ser Ser Gln Pro Gly His Thr Pro His Pro Ala Ala Ser Arg Asp 
    50                  55                  60                  


Pro Val Ala Arg Thr Ser Pro Leu Gln Thr Pro Ala Ala Pro Gly Ala 
65                  70                  75                  80  


Ala Ala Gly Pro Ala Leu Ser Pro Val Pro Pro Val Val His Leu Thr 
                85                  90                  95      


Leu Arg Gln Ala Gly Asp Asp Phe Ser Arg Arg Tyr Arg Arg Asp Phe 
            100                 105                 110         


Ala Glu Met Ser Ser Gln Leu His Leu Thr Pro Phe Thr Ala Arg Gly 
        115                 120                 125             


Arg Phe Ala Thr Val Val Glu Glu Leu Phe Arg Asp Gly Val Asn Trp 
    130                 135                 140                 


Gly Arg Ile Val Ala Phe Phe Glu Phe Gly Gly Val Met Cys Val Glu 
145                 150                 155                 160 


Ser Val Asn Arg Glu Met Ser Pro Leu Val Asp Asn Ile Ala Leu Trp 
                165                 170                 175     


Met Thr Glu Tyr Leu Asn Arg His Leu His Thr Trp Ile Gln Asp Asn 
            180                 185                 190         


Gly Gly Trp Asp Ala Phe Val Glu Leu Tyr Gly Pro Ser Met Arg Pro 
        195                 200                 205             


Leu Phe Asp Phe Ser Trp Leu Ser Leu Lys Thr Leu Leu Ser Leu Ala 
    210                 215                 220                 


Leu Val Gly Ala Cys Ile Thr Leu Gly Ala Tyr Leu Gly His Lys 
225                 230                 235                 


<210>  4
<211>  205
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Ala His Ala Gly Arg Thr Gly Tyr Asp Asn Arg Glu Ile Val Met 
1               5                   10                  15      


Lys Tyr Ile His Tyr Lys Leu Ser Gln Arg Gly Tyr Glu Trp Asp Ala 
            20                  25                  30          


Gly Asp Val Gly Ala Ala Pro Pro Gly Ala Ala Pro Ala Pro Gly Ile 
        35                  40                  45              


Phe Ser Ser Gln Pro Gly His Thr Pro His Pro Ala Ala Ser Arg Asp 
    50                  55                  60                  


Pro Val Ala Arg Thr Ser Pro Leu Gln Thr Pro Ala Ala Pro Gly Ala 
65                  70                  75                  80  


Ala Ala Gly Pro Ala Leu Ser Pro Val Pro Pro Val Val His Leu Thr 
                85                  90                  95      


Leu Arg Gln Ala Gly Asp Asp Phe Ser Arg Arg Tyr Arg Arg Asp Phe 
            100                 105                 110         


Ala Glu Met Ser Ser Gln Leu His Leu Thr Pro Phe Thr Ala Arg Gly 
        115                 120                 125             


Arg Phe Ala Thr Val Val Glu Glu Leu Phe Arg Asp Gly Val Asn Trp 
    130                 135                 140                 


Gly Arg Ile Val Ala Phe Phe Glu Phe Gly Gly Val Met Cys Val Glu 
145                 150                 155                 160 


Ser Val Asn Arg Glu Met Ser Pro Leu Val Asp Asn Ile Ala Leu Trp 
                165                 170                 175     


Met Thr Glu Tyr Leu Asn Arg His Leu His Thr Trp Ile Gln Asp Asn 
            180                 185                 190         


Gly Gly Trp Val Gly Ala Leu Gly Asp Val Ser Leu Gly 
        195                 200                 205 


<210>  5
<211>  6492
<212>  DNA
<213>  Homo sapiens

<400>  5
tttctgtgaa gcagaagtct gggaatcgat ctggaaatcc tcctaatttt tactccctct       60

ccccgcgact cctgattcat tgggaagttt caaatcagct ataactggag agtgctgaag      120

attgatggga tcgttgcctt atgcatttgt tttggtttta caaaaaggaa acttgacaga      180

ggatcatgct gtacttaaaa aatacaacat cacagaggaa gtagactgat attaacaata      240

cttactaata ataacgtgcc tcatgaaata aagatccgaa aggaattgga ataaaaattt      300

cctgcatctc atgccaaggg ggaaacacca gaatcaagtg ttccgcgtga ttgaagacac      360

cccctcgtcc aagaatgcaa agcacatcca ataaaatagc tggattataa ctcctcttct      420

ttctctgggg gccgtggggt gggagctggg gcgagaggtg ccgttggccc ccgttgcttt      480

tcctctggga aggatggcgc acgctgggag aacagggtac gataaccggg agatagtgat      540

gaagtacatc cattataagc tgtcgcagag gggctacgag tgggatgcgg gagatgtggg      600

cgccgcgccc ccgggggccg cccccgcacc gggcatcttc tcctcccagc ccgggcacac      660

gccccatcca gccgcatccc gggacccggt cgccaggacc tcgccgctgc agaccccggc      720

tgcccccggc gccgccgcgg ggcctgcgct cagcccggtg ccacctgtgg tccacctgac      780

cctccgccag gccggcgacg acttctcccg ccgctaccgc cgcgacttcg ccgagatgtc      840

cagccagctg cacctgacgc ccttcaccgc gcggggacgc tttgccacgg tggtggagga      900

gctcttcagg gacggggtga actgggggag gattgtggcc ttctttgagt tcggtggggt      960

catgtgtgtg gagagcgtca accgggagat gtcgcccctg gtggacaaca tcgccctgtg     1020

gatgactgag tacctgaacc ggcacctgca cacctggatc caggataacg gaggctggga     1080

tgcctttgtg gaactgtacg gccccagcat gcggcctctg tttgatttct cctggctgtc     1140

tctgaagact ctgctcagtt tggccctggt gggagcttgc atcaccctgg gtgcctatct     1200

gggccacaag tgaagtcaac atgcctgccc caaacaaata tgcaaaaggt tcactaaagc     1260

agtagaaata atatgcattg tcagtgatgt accatgaaac aaagctgcag gctgtttaag     1320

aaaaaataac acacatataa acatcacaca cacagacaga cacacacaca cacaacaatt     1380

aacagtcttc aggcaaaacg tcgaatcagc tatttactgc caaagggaaa tatcatttat     1440

tttttacatt attaagaaaa aaagatttat ttatttaaga cagtcccatc aaaactcctg     1500

tctttggaaa tccgaccact aattgccaag caccgcttcg tgtggctcca cctggatgtt     1560

ctgtgcctgt aaacatagat tcgctttcca tgttgttggc cggatcacca tctgaagagc     1620

agacggatgg aaaaaggacc tgatcattgg ggaagctggc tttctggctg ctggaggctg     1680

gggagaaggt gttcattcac ttgcatttct ttgccctggg ggctgtgata ttaacagagg     1740

gagggttcct gtggggggaa gtccatgcct ccctggcctg aagaagagac tctttgcata     1800

tgactcacat gatgcatacc tggtgggagg aaaagagttg ggaacttcag atggacctag     1860

tacccactga gatttccacg ccgaaggaca gcgatgggaa aaatgccctt aaatcatagg     1920

aaagtatttt tttaagctac caattgtgcc gagaaaagca ttttagcaat ttatacaata     1980

tcatccagta ccttaagccc tgattgtgta tattcatata ttttggatac gcacccccca     2040

actcccaata ctggctctgt ctgagtaaga aacagaatcc tctggaactt gaggaagtga     2100

acatttcggt gacttccgca tcaggaaggc tagagttacc cagagcatca ggccgccaca     2160

agtgcctgct tttaggagac cgaagtccgc agaacctgcc tgtgtcccag cttggaggcc     2220

tggtcctgga actgagccgg ggccctcact ggcctcctcc agggatgatc aacagggcag     2280

tgtggtctcc gaatgtctgg aagctgatgg agctcagaat tccactgtca agaaagagca     2340

gtagaggggt gtggctgggc ctgtcaccct ggggccctcc aggtaggccc gttttcacgt     2400

ggagcatggg agccacgacc cttcttaaga catgtatcac tgtagaggga aggaacagag     2460

gccctgggcc cttcctatca gaaggacatg gtgaaggctg ggaacgtgag gagaggcaat     2520

ggccacggcc cattttggct gtagcacatg gcacgttggc tgtgtggcct tggcccacct     2580

gtgagtttaa agcaaggctt taaatgactt tggagagggt cacaaatcct aaaagaagca     2640

ttgaagtgag gtgtcatgga ttaattgacc cctgtctatg gaattacatg taaaacatta     2700

tcttgtcact gtagtttggt tttatttgaa aacctgacaa aaaaaaagtt ccaggtgtgg     2760

aatatggggg ttatctgtac atcctggggc attaaaaaaa aaatcaatgg tggggaacta     2820

taaagaagta acaaaagaag tgacatcttc agcaaataaa ctaggaaatt tttttttctt     2880

ccagtttaga atcagccttg aaacattgat ggaataactc tgtggcatta ttgcattata     2940

taccatttat ctgtattaac tttggaatgt actctgttca atgtttaatg ctgtggttga     3000

tatttcgaaa gctgctttaa aaaaatacat gcatctcagc gtttttttgt ttttaattgt     3060

atttagttat ggcctataca ctatttgtga gcaaaggtga tcgttttctg tttgagattt     3120

ttatctcttg attcttcaaa agcattctga gaaggtgaga taagccctga gtctcagcta     3180

cctaagaaaa acctggatgt cactggccac tgaggagctt tgtttcaacc aagtcatgtg     3240

catttccacg tcaacagaat tgtttattgt gacagttata tctgttgtcc ctttgacctt     3300

gtttcttgaa ggtttcctcg tccctgggca attccgcatt taattcatgg tattcaggat     3360

tacatgcatg tttggttaaa cccatgagat tcattcagtt aaaaatccag atggcaaatg     3420

accagcagat tcaaatctat ggtggtttga cctttagaga gttgctttac gtggcctgtt     3480

tcaacacaga cccacccaga gccctcctgc cctccttccg cgggggcttt ctcatggctg     3540

tccttcaggg tcttcctgaa atgcagtggt gcttacgctc caccaagaaa gcaggaaacc     3600

tgtggtatga agccagacct ccccggcggg cctcagggaa cagaatgatc agacctttga     3660

atgattctaa tttttaagca aaatattatt ttatgaaagg tttacattgt caaagtgatg     3720

aatatggaat atccaatcct gtgctgctat cctgccaaaa tcattttaat ggagtcagtt     3780

tgcagtatgc tccacgtggt aagatcctcc aagctgcttt agaagtaaca atgaagaacg     3840

tggacgtttt taatataaag cctgttttgt cttttgttgt tgttcaaacg ggattcacag     3900

agtatttgaa aaatgtatat atattaagag gtcacggggg ctaattgctg gctggctgcc     3960

ttttgctgtg gggttttgtt acctggtttt aataacagta aatgtgccca gcctcttggc     4020

cccagaactg tacagtattg tggctgcact tgctctaaga gtagttgatg ttgcattttc     4080

cttattgtta aaaacatgtt agaagcaatg aatgtatata aaagcctcaa ctagtcattt     4140

ttttctcctc ttcttttttt tcattatatc taattatttt gcagttgggc aacagagaac     4200

catccctatt ttgtattgaa gagggattca catctgcatc ttaactgctc tttatgaatg     4260

aaaaaacagt cctctgtatg tactcctctt tacactggcc agggtcagag ttaaatagag     4320

tatatgcact ttccaaattg gggacaaggg ctctaaaaaa agccccaaaa ggagaagaac     4380

atctgagaac ctcctcggcc ctcccagtcc ctcgctgcac aaatactccg caagagaggc     4440

cagaatgaca gctgacaggg tctatggcca tcgggtcgtc tccgaagatt tggcaggggc     4500

agaaaactct ggcaggctta agatttggaa taaagtcaca gaattaagga agcacctcaa     4560

tttagttcaa acaagacgcc aacattctct ccacagctca cttacctctc tgtgttcaga     4620

tgtggccttc catttatatg tgatctttgt tttattagta aatgcttatc atctaaagat     4680

gtagctctgg cccagtggga aaaattagga agtgattata aatcgagagg agttataata     4740

atcaagatta aatgtaaata atcagggcaa tcccaacaca tgtctagctt tcacctccag     4800

gatctattga gtgaacagaa ttgcaaatag tctctatttg taattgaact tatcctaaaa     4860

caaatagttt ataaatgtga acttaaactc taattaattc caactgtact tttaaggcag     4920

tggctgtttt tagactttct tatcacttat agttagtaat gtacacctac tctatcagag     4980

aaaaacagga aaggctcgaa atacaagcca ttctaaggaa attagggagt cagttgaaat     5040

tctattctga tcttattctg tggtgtcttt tgcagcccag acaaatgtgg ttacacactt     5100

tttaagaaat acaattctac attgtcaagc ttatgaaggt tccaatcaga tctttattgt     5160

tattcaattt ggatctttca gggatttttt ttttaaatta ttatgggaca aaggacattt     5220

gttggagggg tgggagggag gaagaatttt taaatgtaaa acattcccaa gtttggatca     5280

gggagttgga agttttcaga ataaccagaa ctaagggtat gaaggacctg tattggggtc     5340

gatgtgatgc ctctgcgaag aaccttgtgt gacaaatgag aaacattttg aagtttgtgg     5400

tacgaccttt agattccaga gacatcagca tggctcaaag tgcagctccg tttggcagtg     5460

caatggtata aatttcaagc tggatatgtc taatgggtat ttaaacaata aatgtgcagt     5520

tttaactaac aggatattta atgacaacct tctggttggt agggacatct gtttctaaat     5580

gtttattatg tacaatacag aaaaaaattt tataaaatta agcaatgtga aactgaattg     5640

gagagtgata atacaagtcc tttagtctta cccagtgaat cattctgttc catgtctttg     5700

gacaaccatg accttggaca atcatgaaat atgcatctca ctggatgcaa agaaaatcag     5760

atggagcatg aatggtactg taccggttca tctggactgc cccagaaaaa taacttcaag     5820

caaacatcct atcaacaaca aggttgttct gcataccaag ctgagcacag aagatgggaa     5880

cactggtgga ggatggaaag gctcgctcaa tcaagaaaat tctgagacta ttaataaata     5940

agactgtagt gtagatactg agtaaatcca tgcacctaaa ccttttggaa aatctgccgt     6000

gggccctcca gatagctcat ttcattaagt ttttccctcc aaggtagaat ttgcaagagt     6060

gacagtggat tgcatttctt ttggggaagc tttcttttgg tggttttgtt tattatacct     6120

tcttaagttt tcaaccaagg tttgcttttg ttttgagtta ctggggttat ttttgtttta     6180

aataaaaata agtgtacaat aagtgttttt gtattgaaag cttttgttat caagattttc     6240

atacttttac cttccatggc tctttttaag attgatactt ttaagaggtg gctgatattc     6300

tgcaacactg tacacataaa aaatacggta aggatacttt acatggttaa ggtaaagtaa     6360

gtctccagtt ggccaccatt agctataatg gcactttgtt tgtgttgttg gaaaaagtca     6420

cattgccatt aaactttcct tgtctgtcta gttaatattg tgaagaaaaa taaagtacag     6480

tgtgagatac tg                                                         6492


<210>  6
<211>  1207
<212>  DNA
<213>  Homo sapiens

<400>  6
tttctgtgaa gcagaagtct gggaatcgat ctggaaatcc tcctaatttt tactccctct       60

ccccgcgact cctgattcat tgggaagttt caaatcagct ataactggag agtgctgaag      120

attgatggga tcgttgcctt atgcatttgt tttggtttta caaaaaggaa acttgacaga      180

ggatcatgct gtacttaaaa aatacaacat cacagaggaa gtagactgat attaacaata      240

cttactaata ataacgtgcc tcatgaaata aagatccgaa aggaattgga ataaaaattt      300

cctgcatctc atgccaaggg ggaaacacca gaatcaagtg ttccgcgtga ttgaagacac      360

cccctcgtcc aagaatgcaa agcacatcca ataaaatagc tggattataa ctcctcttct      420

ttctctgggg gccgtggggt gggagctggg gcgagaggtg ccgttggccc ccgttgcttt      480

tcctctggga aggatggcgc acgctgggag aacagggtac gataaccggg agatagtgat      540

gaagtacatc cattataagc tgtcgcagag gggctacgag tgggatgcgg gagatgtggg      600

cgccgcgccc ccgggggccg cccccgcacc gggcatcttc tcctcccagc ccgggcacac      660

gccccatcca gccgcatccc gggacccggt cgccaggacc tcgccgctgc agaccccggc      720

tgcccccggc gccgccgcgg ggcctgcgct cagcccggtg ccacctgtgg tccacctgac      780

cctccgccag gccggcgacg acttctcccg ccgctaccgc cgcgacttcg ccgagatgtc      840

cagccagctg cacctgacgc ccttcaccgc gcggggacgc tttgccacgg tggtggagga      900

gctcttcagg gacggggtga actgggggag gattgtggcc ttctttgagt tcggtggggt      960

catgtgtgtg gagagcgtca accgggagat gtcgcccctg gtggacaaca tcgccctgtg     1020

gatgactgag tacctgaacc ggcacctgca cacctggatc caggataacg gaggctgggt     1080

aggtgcactt ggtgatgtga gtctgggctg aggccacagg tccgagatgc gggggttgga     1140

gtgcgggtgg gctcctgggg caatgggagg ctgtggagcc ggcgaaataa aatcagagtt     1200

gttgcta                                                               1207


<210>  7
<211>  233
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Ser Gln Ser Asn Arg Glu Leu Val Val Asp Phe Leu Ser Tyr Lys 
1               5                   10                  15      


Leu Ser Gln Lys Gly Tyr Ser Trp Ser Gln Phe Ser Asp Val Glu Glu 
            20                  25                  30          


Asn Arg Thr Glu Ala Pro Glu Gly Thr Glu Ser Glu Met Glu Thr Pro 
        35                  40                  45              


Ser Ala Ile Asn Gly Asn Pro Ser Trp His Leu Ala Asp Ser Pro Ala 
    50                  55                  60                  


Val Asn Gly Ala Thr Ala His Ser Ser Ser Leu Asp Ala Arg Glu Val 
65                  70                  75                  80  


Ile Pro Met Ala Ala Val Lys Gln Ala Leu Arg Glu Ala Gly Asp Glu 
                85                  90                  95      


Phe Glu Leu Arg Tyr Arg Arg Ala Phe Ser Asp Leu Thr Ser Gln Leu 
            100                 105                 110         


His Ile Thr Pro Gly Thr Ala Tyr Gln Ser Phe Glu Gln Val Val Asn 
        115                 120                 125             


Glu Leu Phe Arg Asp Gly Val Asn Trp Gly Arg Ile Val Ala Phe Phe 
    130                 135                 140                 


Ser Phe Gly Gly Ala Leu Cys Val Glu Ser Val Asp Lys Glu Met Gln 
145                 150                 155                 160 


Val Leu Val Ser Arg Ile Ala Ala Trp Met Ala Thr Tyr Leu Asn Asp 
                165                 170                 175     


His Leu Glu Pro Trp Ile Gln Glu Asn Gly Gly Trp Asp Thr Phe Val 
            180                 185                 190         


Glu Leu Tyr Gly Asn Asn Ala Ala Ala Glu Ser Arg Lys Gly Gln Glu 
        195                 200                 205             


Arg Phe Asn Arg Trp Phe Leu Thr Gly Met Thr Val Ala Gly Val Val 
    210                 215                 220                 


Leu Leu Gly Ser Leu Phe Ser Arg Lys 
225                 230             


<210>  8
<211>  926
<212>  DNA
<213>  Homo sapiens

<400>  8
gaatctcttt ctctcccttc agaatcttat cttggctttg gatcttagaa gagaatcact       60

aaccagagac gagactcagt gagtgagcag gtgttttgga caatggactg gttgagccca      120

tccctattat aaaaatgtct cagagcaacc gggagctggt ggttgacttt ctctcctaca      180

agctttccca gaaaggatac agctggagtc agtttagtga tgtggaagag aacaggactg      240

aggccccaga agggactgaa tcggagatgg agacccccag tgccatcaat ggcaacccat      300

cctggcacct ggcagacagc cccgcggtga atggagccac tgcgcacagc agcagtttgg      360

atgcccggga ggtgatcccc atggcagcag taaagcaagc gctgagggag gcaggcgacg      420

agtttgaact gcggtaccgg cgggcattca gtgacctgac atcccagctc cacatcaccc      480

cagggacagc atatcagagc tttgaacagg tagtgaatga actcttccgg gatggggtaa      540

actggggtcg cattgtggcc tttttctcct tcggcggggc actgtgcgtg gaaagcgtag      600

acaaggagat gcaggtattg gtgagtcgga tcgcagcttg gatggccact tacctgaatg      660

accacctaga gccttggatc caggagaacg gcggctggga tacttttgtg gaactctatg      720

ggaacaatgc agcagccgag agccgaaagg gccaggaacg cttcaaccgc tggttcctga      780

cgggcatgac tgtggccggc gtggttctgc tgggctcact cttcagtcgg aaatgaccag      840

acactgacca tccactctac cctcccaccc ccttctctgc tccaccacat cctccgtcca      900

gccgccattg ccaccaggag aacccg                                           926


<210>  9
<211>  497
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Thr Phe Asn Ser Phe Glu Gly Ser Lys Thr Cys Val Pro Ala Asp 
1               5                   10                  15      


Ile Asn Lys Glu Glu Glu Phe Val Glu Glu Phe Asn Arg Leu Lys Thr 
            20                  25                  30          


Phe Ala Asn Phe Pro Ser Gly Ser Pro Val Ser Ala Ser Thr Leu Ala 
        35                  40                  45              


Arg Ala Gly Phe Leu Tyr Thr Gly Glu Gly Asp Thr Val Arg Cys Phe 
    50                  55                  60                  


Ser Cys His Ala Ala Val Asp Arg Trp Gln Tyr Gly Asp Ser Ala Val 
65                  70                  75                  80  


Gly Arg His Arg Lys Val Ser Pro Asn Cys Arg Phe Ile Asn Gly Phe 
                85                  90                  95      


Tyr Leu Glu Asn Ser Ala Thr Gln Ser Thr Asn Ser Gly Ile Gln Asn 
            100                 105                 110         


Gly Gln Tyr Lys Val Glu Asn Tyr Leu Gly Ser Arg Asp His Phe Ala 
        115                 120                 125             


Leu Asp Arg Pro Ser Glu Thr His Ala Asp Tyr Leu Leu Arg Thr Gly 
    130                 135                 140                 


Gln Val Val Asp Ile Ser Asp Thr Ile Tyr Pro Arg Asn Pro Ala Met 
145                 150                 155                 160 


Tyr Ser Glu Glu Ala Arg Leu Lys Ser Phe Gln Asn Trp Pro Asp Tyr 
                165                 170                 175     


Ala His Leu Thr Pro Arg Glu Leu Ala Ser Ala Gly Leu Tyr Tyr Thr 
            180                 185                 190         


Gly Ile Gly Asp Gln Val Gln Cys Phe Cys Cys Gly Gly Lys Leu Lys 
        195                 200                 205             


Asn Trp Glu Pro Cys Asp Arg Ala Trp Ser Glu His Arg Arg His Phe 
    210                 215                 220                 


Pro Asn Cys Phe Phe Val Leu Gly Arg Asn Leu Asn Ile Arg Ser Glu 
225                 230                 235                 240 


Ser Asp Ala Val Ser Ser Asp Arg Asn Phe Pro Asn Ser Thr Asn Leu 
                245                 250                 255     


Pro Arg Asn Pro Ser Met Ala Asp Tyr Glu Ala Arg Ile Phe Thr Phe 
            260                 265                 270         


Gly Thr Trp Ile Tyr Ser Val Asn Lys Glu Gln Leu Ala Arg Ala Gly 
        275                 280                 285             


Phe Tyr Ala Leu Gly Glu Gly Asp Lys Val Lys Cys Phe His Cys Gly 
    290                 295                 300                 


Gly Gly Leu Thr Asp Trp Lys Pro Ser Glu Asp Pro Trp Glu Gln His 
305                 310                 315                 320 


Ala Lys Trp Tyr Pro Gly Cys Lys Tyr Leu Leu Glu Gln Lys Gly Gln 
                325                 330                 335     


Glu Tyr Ile Asn Asn Ile His Leu Thr His Ser Leu Glu Glu Cys Leu 
            340                 345                 350         


Val Arg Thr Thr Glu Lys Thr Pro Ser Leu Thr Arg Arg Ile Asp Asp 
        355                 360                 365             


Thr Ile Phe Gln Asn Pro Met Val Gln Glu Ala Ile Arg Met Gly Phe 
    370                 375                 380                 


Ser Phe Lys Asp Ile Lys Lys Ile Met Glu Glu Lys Ile Gln Ile Ser 
385                 390                 395                 400 


Gly Ser Asn Tyr Lys Ser Leu Glu Val Leu Val Ala Asp Leu Val Asn 
                405                 410                 415     


Ala Gln Lys Asp Ser Met Gln Asp Glu Ser Ser Gln Thr Ser Leu Gln 
            420                 425                 430         


Lys Glu Ile Ser Thr Glu Glu Gln Leu Arg Arg Leu Gln Glu Glu Lys 
        435                 440                 445             


Leu Cys Lys Ile Cys Met Asp Arg Asn Ile Ala Ile Val Phe Val Pro 
    450                 455                 460                 


Cys Gly His Leu Val Thr Cys Lys Gln Cys Ala Glu Ala Val Asp Lys 
465                 470                 475                 480 


Cys Pro Met Cys Tyr Thr Val Ile Thr Phe Lys Gln Lys Ile Phe Met 
                485                 490                 495     


Ser 
    


<210>  10
<211>  8460
<212>  DNA
<213>  Homo sapiens

<400>  10
gctggggcca agccgcagag cggagttggc atttccagat tggggctcgg gccgcgcctc       60

ctccgggacc ctccccttgg accgagccga tcgccgcggg gcagttcggg ccggctgtcc      120

tggcgcgaaa aggtggacaa gtcctatttt caagagaaga tgacttttaa cagttttgaa      180

ggatctaaaa cttgtgtacc tgcagacatc aataaggaag aagaatttgt agaagagttt      240

aatagattaa aaacttttgc taattttcca agtggtagtc ctgtttcagc atcaacactg      300

gcacgagcag ggtttcttta tactggtgaa ggagataccg tgcggtgctt tagttgtcat      360

gcagctgtag atagatggca atatggagac tcagcagttg gaagacacag gaaagtatcc      420

ccaaattgca gatttatcaa cggcttttat cttgaaaata gtgccacgca gtctacaaat      480

tctggtatcc agaatggtca gtacaaagtt gaaaactatc tgggaagcag agatcatttt      540

gccttagaca ggccatctga gacacatgca gactatcttt tgagaactgg gcaggttgta      600

gatatatcag acaccatata cccgaggaac cctgccatgt atagtgaaga agctagatta      660

aagtcctttc agaactggcc agactatgct cacctaaccc caagagagtt agcaagtgct      720

ggactctact acacaggtat tggtgaccaa gtgcagtgct tttgttgtgg tggaaaactg      780

aaaaattggg aaccttgtga tcgtgcctgg tcagaacaca ggcgacactt tcctaattgc      840

ttctttgttt tgggccggaa tcttaatatt cgaagtgaat ctgatgctgt gagttctgat      900

aggaatttcc caaattcaac aaatcttcca agaaatccat ccatggcaga ttatgaagca      960

cggatcttta cttttgggac atggatatac tcagttaaca aggagcagct tgcaagagct     1020

ggattttatg ctttaggtga aggtgataaa gtaaagtgct ttcactgtgg aggagggcta     1080

actgattgga agcccagtga agacccttgg gaacaacatg ctaaatggta tccagggtgc     1140

aaatatctgt tagaacagaa gggacaagaa tatataaaca atattcattt aactcattca     1200

cttgaggagt gtctggtaag aactactgag aaaacaccat cactaactag aagaattgat     1260

gataccatct tccaaaatcc tatggtacaa gaagctatac gaatggggtt cagtttcaag     1320

gacattaaga aaataatgga ggaaaaaatt cagatatctg ggagcaacta taaatcactt     1380

gaggttctgg ttgcagatct agtgaatgct cagaaagaca gtatgcaaga tgagtcaagt     1440

cagacttcat tacagaaaga gattagtact gaagagcagc taaggcgcct gcaagaggag     1500

aagctttgca aaatctgtat ggatagaaat attgctatcg tttttgttcc ttgtggacat     1560

ctagtcactt gtaaacaatg tgctgaagca gttgacaagt gtcccatgtg ctacacagtc     1620

attactttca agcaaaaaat ttttatgtct taatctaact ctatagtagg catgttatgt     1680

tgttcttatt accctgattg aatgtgtgat gtgaactgac tttaagtaat caggattgaa     1740

ttccattagc atttgctacc aagtaggaaa aaaaatgtac atggcagtgt tttagttggc     1800

aatataatct ttgaatttct tgatttttca gggtattagc tgtattatcc atttttttta     1860

ctgttattta attgaaacca tagactaaga ataagaagca tcatactata actgaacaca     1920

atgtgtattc atagtatact gatttaattt ctaagtgtaa gtgaattaat catctggatt     1980

ttttattctt ttcagatagg cttaacaaat ggagctttct gtatataaat gtggagatta     2040

gagttaatct ccccaatcac ataatttgtt ttgtgtgaaa aaggaataaa ttgttccatg     2100

ctggtggaaa gatagagatt gtttttagag gttggttgtt gtgttttagg attctgtcca     2160

ttttctttta aagttataaa cacgtacttg tgcgaattat ttttttaaag tgatttgcca     2220

tttttgaaag cgtatttaat gatagaatac tatcgagcca acatgtactg acatggaaag     2280

atgtcaaaga tatgttaagt gtaaaatgca agtggcaaaa cactatgtat agtctgagcc     2340

agatcaaagt atgtatgttt ttaatatgca tagaacaaaa gatttggaaa gatatacacc     2400

aaactgttaa atgtggtttc tcttcgggga gggggggatt gggggagggg ccccagaggg     2460

gttttatagg ggccttttca ctttctactt ttttcatttt gttctgttcg aattttttat     2520

aagtatgtat tacttttgta atcagaattt ttagaaagta ttttgctgat ttaaaggctt     2580

aggcatgttc aaacgcctgc aaaactactt atcactcagc tttagttttt ctaatccaag     2640

aaggcagggc agttaacctt tttggtgcca atgtgaaatg taaatgattt tatgtttttc     2700

ctgctttgtg gatgaaaaat atttctgagt ggtagttttt tgacaggtag accatgtctt     2760

atcttgtttc aaaataagta tttctgattt tgtaaaatga aatataaaat atgtctcaga     2820

tcttccaatt aattagtaag gattcatcct taatccttgc tagtttaagc ctgcctaagt     2880

cactttacta aaagatcttt gttaactcag tattttaaac atctgtcagc ttatgtaggt     2940

aaaagtagaa gcatgtttgt acactgcttg tagttatagt gacagctttc catgttgaga     3000

ttctcatatc atcttgtatc ttaaagtttc atgtgagttt ttaccgttag gatgattaag     3060

atgtatatag gacaaaatgt taagtctttc ctctacctac atttgttttc ttggctagta     3120

atagtagtag atacttctga aataaatgtt ctctcaagat ccttaaaacc tcttggaaat     3180

tataaaaata ttggcaagaa aagaagaata gttgtttaaa tattttttaa aaaacacttg     3240

aataagaatc agtagggtat aaactagaag tttaaaaatg cttcatagaa cgtccagggt     3300

ttacattaca agattctcac aacaaaccta ttgtagaggt gagtaaggca tgttactaca     3360

gaggaaagtt tgagagtaaa actgtaaaaa attatatttt tgttgtactt tctaagagaa     3420

agagtattgt tatgttctcc taacttctgt tgattactac tttaagtgat attcatttaa     3480

aacattgcaa atttatttta tttatttaat tttctttttg agatggagtc ttgcttgtca     3540

cccaggctgg agtgcagtgg agtgatctct gctcactgca acctccgcct tctgggttca     3600

agcgattctc gtgcctcagc ttcctgagta gctggaatta caggcaggtg ccaccatgcc     3660

cgactaattt ttttttattt ttagtagaga cggggtttca ccatgttggc caggctggta     3720

tcaaactcct gacctcaaga gatccactcg ccttgccctc ccaaagtgct gggattacag     3780

gcttgagcca ccacgcccgg ctaaaacatt gcaaatttaa atgagagttt taaaaattaa     3840

ataatgactg ccctgtttct gttttagtat gtaaatcctc agttcttcac ctttgcactg     3900

tctgccactt agtttggtta tatagtcatt aacttgaatt tggtctgtat agtctagact     3960

ttaaatttaa agttttctac aaggggagaa aagtgttaaa atttttaaaa tatgttttcc     4020

aggacacttc acttccaagt caggtaggta gttcaatcta gttgttagcc aaggactcaa     4080

ggactgaatt gttttaacat aaggcttttc ctgttctggg agccgcactt cattaaaatt     4140

cttctaaaac ttgtatgttt agagttaagc aagacttttt ttcttcctct ccatgagttg     4200

tgaaatttaa tgcacaacgc tgatgtggct aacaagttta ttttaagaat tgtttagaaa     4260

tgctgttgct tcaggttctt aaaatcactc agcactccaa cttctaatca aatttttgga     4320

gacttaacag catttgtctg tgtttgaact ataaaaagca ccggatcttt tccatctaat     4380

tccgcaaaaa ttgatcattt gcaaagtcaa aactatagcc atatccaaat cttttccccc     4440

tcccaagagt tctcagtgtc tacatgtaga ctattccttt tctgtataaa gttcactcta     4500

ggatttcaag tcaccactta ttttacattt tagtcatgca aagattcaag tagttttgca     4560

ataagtactt atctttattt gtaataattt agtctgctga tcaaaagcat tgtcttaatt     4620

tttgagaact ggttttagca tttacaaact aaattccagt taattaatta atagctttat     4680

attgcctttc ctgctacatt tggttttttc ccctgtccct ttgattacgg gctaaggtag     4740

ggtagagtgg gtgtagtgag tgtatataat gtgatttggc cctgtgtatt atgatatttt     4800

gttatttttg ttgttatatt atttacattt cagtagttgt tttttgtgtt tccattttag     4860

tggataaaat ttgtattttg aactatgaat ggagactacc gccccagcat tagtttcaca     4920

tgatataccc tttaaacccg aatcattgtt ttatttcctg attacacagg tgttgaatgg     4980

ggaaaggggc tagtatatca gtaggatata ctatgggatg tatatatatc attgctgtta     5040

gagaaatgaa ataaaatggg gctgggctca gtggctcacg cctgtaatcc cagcactttg     5100

ggaggctgag gcaggtggat cacgaggtca ggagatcgag accatcctgg ctaacacggt     5160

gaaaccccgt ctctactaaa aaacagaaaa ttagccgggc gtggtggcgg gcgcctgtag     5220

tcccagctac tcgggaggct gaggcaggag aatggtgtga acccgggagg cagagcttgc     5280

agtgagccga gatctcgcca ctgcactcca gcctgggcaa cagagcaaga ctctgtctca     5340

aaaaaaaaaa aaaaagaaat aagaaaatgg gaagcaatat ttgacatagt tctttttagt     5400

caaatctact tgttaaaaaa agggtagcag tttattcatc tgtgaaagga aaataatact     5460

tatcttacaa ggttgcaaga gctcaaggag accatgtatg taaagttcct gctgtaaata     5520

tgaactccca tcctaatacc cttttacctc tctgtgggtt tgtcttgacc tggaaatttg     5580

ggctaaaact tagaaaaaat tcttacatga taactcagtg atgcttactc atagtttttg     5640

gtgtttctca tagataagat ataaatcagc tgggcgcggt ggctcatgcc tgtaatccca     5700

gcactttggg aggccgaggc gggcagatca cctgaggtcg ggaggtcgag accagcctga     5760

ccaacatgga gaaaccccgt ctctactaaa aatacaaaat tagctgggcg tggtggctca     5820

tgcctgtaat cccagctact tgggaggctg aggcaggaga atcgcttgaa cccaggaggc     5880

ggaggttgtg gtgagcgaag atcgtgccat tgcactccag cctgggcaac aagagcaaaa     5940

ctctgtctca aaaaaaaaaa aagatataaa tcacaataaa taaataggtc aatacaaatg     6000

ttagccaggc gtggtggcac atgcccatag tcgcagctac tctggaggca gaggcaggag     6060

gatcacttga gcccatgaat ttgaggcagc agtgagctat gattgtgcca ctgtactcca     6120

gtctgggtga cagagtgaga ccccatctct aaataaatag gtcaaaccct taaaaatatt     6180

taaattctta aaaaattgaa aagattattc ttctcaaatt tagttgagct ttctaagaga     6240

agcaattggc tttttcccac ttcaataatc attttcagtt tgactcatac agttaacaca     6300

atgtgaattt cttcctcagc ataacagagt tatagaatga cagggctgga agtgacctta     6360

gagagtatcc agttctttca ttttacaggt gaggcaactg agactcaaag gtgatgtaat     6420

ttgtgcaaag attatagcta attagtagca gagccctgac tgggacatag tttgaaggtg     6480

aaaaacttca ccaagctacc tttcttgaaa ggtccaaatg tttatgtttt caactactct     6540

ttccactgta ccataacttt cactacatat taaatgacac tttataacta atataatagg     6600

acaatcatca atgcatatat agccagccct tcatatctgt gggttttgca tccatggatt     6660

caaccaagga ggaattgaaa acactgagaa aaaaaaaaaa gaccacacaa taaaaaaaaa     6720

aaatacaaaa taatacaaag aaaaagccaa aattgtcata ctgttgttaa gcaacagtat     6780

aacaactatt tacatagcat taaggttggt gcaaaaatgc aaaaaaaaaa aaagcaatta     6840

tttttaaacc aacctaatat attgtattag gtattaaagt catctggaca tgaattaaag     6900

tatatgatgc cagcctggac aaaaggcaaa accctgtctc tacaaaaaat acaaaaatta     6960

gctgggcatg gtggtgtgtg cctgtagtcc tggctactcc ggagcctgag gtgggaggat     7020

cgcttgagtc tgggaggcag aggctgcatt gagctatgat catggcactg cattccagcc     7080

tgggtgacag tgcaagacct tgtctcagaa taaataaagt atgtgatgaa gatgtgcata     7140

cattatatgc aaatactgtt tttttttttt ttaatttaaa cagtctcact gtgttgccca     7200

ggatggagtg caatggcaca atcttggctc atggcaaact ctgcctcgca agcagctggg     7260

actacaggca tgctccacgg tgcccagtta attttttttg tattcttagt agagacaggg     7320

tttcaccatg ttggccaggc tagtcttgaa tttctgacct caagtgattc atctcccaaa     7380

gtgctgggat tacaggcgtg agccaccacg gccggctaat ttttgtattt tttagtagtg     7440

actggtttcg cggtgttgac caggctggtc tcgaactcct gatctcaggt gatctgcctg     7500

cctcggcctc acaaagtgct gggattacag gtgtgaacca ctgctcccgg ccttgtgtga     7560

ttttatctaa gggacttaag cgtcctcagg tcctaggggg tcgtgaaacc aaaaccccag     7620

ggatagcaag ggacaattgt atcttcaaag tagacaaatg gcgccgggca cggtggctca     7680

cgcctgtaat cccagcagtt tccgaggctg aggcaggcgg ctcacctgag gtcaggagtt     7740

ggagaccagc ctggccaaca tgctgaaacc ctgtctgtac aaaaatacaa aaatagctgg     7800

gcatggtggc gcatgcctgt agtcccagct actagagcga ctgaggcagg agaattgctt     7860

gaacctggga ggcggaggtt gcagggagcc aagatggcgc caccgcactc cagcctaggt     7920

gatagagtga gactccctct caaaaacaaa acaaaacaaa aaaattagac aaatgctaca     7980

ttaatgtttg ggtggtcaga ttctactttg aatctgaagt ttgcagatat gcctatagat     8040

ttttggagtt taccactttc ttattctgta tcattaatgt aatattttaa attactatat     8100

atgttaccat ttttctggat ttagtaagaa atttgcagtt ttggtttgat gtaacaaggg     8160

ttttaatgta atttatgtta gattttgcat ttttttcatt actgttatat tttaacctga     8220

ctgactgatc taattgtatt agtattgtga ataatcatgt gaaatgtttt gagacagagt     8280

actatatttg tgaatataat tttatggttt ttttcactta gaacctttct gtgtggaaaa     8340

ctaagaaaat tgctttctgc tgtataatct ggcattcatt gtagattaaa gcttattttt     8400

ctgtgaataa aacgtattca ataaaatact attctttaaa attatatcat aaaaaaaaaa     8460


<210>  11
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward primer for human ARTS

<400>  11
gagacgagag tggcctgaac cga                                               23


<210>  12
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse primer for human ARTS

<400>  12
aacaggaacc tgtgaccacc tgc                                               23


<210>  13
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward primer for human GAPDH

<400>  13
atggggaagg tgaaggtcg                                                    19


<210>  14
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse primer for human GAPDH

<400>  14
ggggtcattg atggcaacaa ta                                                22


<210>  15
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BH-3 mimetic compound (TW-37)

<400>  15
tctcccagcg tgcgccat                                                     18


<210>  16
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ARTS C' terminus

<400>  16

Tyr Gly Pro Ser Leu Arg Leu Leu Ala Pro Pro Gly Ala Val Lys Gly 
1               5                   10                  15      


Thr Gly Gln Glu His Gln Gly Gln Gly Cys His 
            20                  25          


<210>  17
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ARTS C' terminal fragment

<400>  17

Tyr Gly Pro Ser Leu Arg Leu Leu Ala 
1               5                   


<210>  18
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ARTS C' terminal fragment

<400>  18

Pro Pro Gly Ala Val Lys Gly Thr Gly 
1               5                   


<210>  19
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ARTS C' terminal fragment

<400>  19

Gln Glu His Gln Gly Gln Gly Cys His 
1               5                   


<210>  20
<211>  128
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ARTS N' terminal fragment residues 1-128

<400>  20

Met Ile Lys Arg Phe Leu Glu Asp Thr Thr Asp Asp Gly Glu Leu Ser 
1               5                   10                  15      


Lys Phe Val Lys Asp Phe Ser Gly Asn Ala Ser Cys His Pro Pro Glu 
            20                  25                  30          


Ala Lys Thr Trp Ala Ser Arg Pro Gln Val Pro Glu Pro Arg Pro Gln 
        35                  40                  45              


Ala Pro Asp Leu Tyr Asp Asp Asp Leu Glu Phe Arg Pro Pro Ser Arg 
    50                  55                  60                  


Pro Gln Ser Ser Asp Asn Gln Gln Tyr Phe Cys Ala Pro Ala Pro Leu 
65                  70                  75                  80  


Ser Pro Ser Ala Arg Pro Arg Ser Pro Trp Gly Lys Leu Asp Pro Tyr 
                85                  90                  95      


Asp Ser Ser Glu Asp Asp Lys Glu Tyr Val Gly Phe Ala Thr Leu Pro 
            100                 105                 110         


Asn Gln Val His Arg Lys Ser Val Lys Lys Gly Phe Asp Phe Thr Leu 
        115                 120                 125             


<210>  21
<211>  148
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ARTS N' terminal fragment residues 1-148

<400>  21

Met Ile Lys Arg Phe Leu Glu Asp Thr Thr Asp Asp Gly Glu Leu Ser 
1               5                   10                  15      


Lys Phe Val Lys Asp Phe Ser Gly Asn Ala Ser Cys His Pro Pro Glu 
            20                  25                  30          


Ala Lys Thr Trp Ala Ser Arg Pro Gln Val Pro Glu Pro Arg Pro Gln 
        35                  40                  45              


Ala Pro Asp Leu Tyr Asp Asp Asp Leu Glu Phe Arg Pro Pro Ser Arg 
    50                  55                  60                  


Pro Gln Ser Ser Asp Asn Gln Gln Tyr Phe Cys Ala Pro Ala Pro Leu 
65                  70                  75                  80  


Ser Pro Ser Ala Arg Pro Arg Ser Pro Trp Gly Lys Leu Asp Pro Tyr 
                85                  90                  95      


Asp Ser Ser Glu Asp Asp Lys Glu Tyr Val Gly Phe Ala Thr Leu Pro 
            100                 105                 110         


Asn Gln Val His Arg Lys Ser Val Lys Lys Gly Phe Asp Phe Thr Leu 
        115                 120                 125             


Met Val Ala Gly Glu Ser Gly Leu Gly Lys Ser Thr Leu Val Asn Ser 
    130                 135                 140                 


Leu Phe Leu Thr 
145             


<210>  22
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ARTS N' terminal fragment residues 106-148

<400>  22

Val Gly Phe Ala Thr Leu Pro Asn Gln Val His Arg Lys Ser Val Lys 
1               5                   10                  15      


Lys Gly Phe Asp Phe Thr Leu Met Val Ala Gly Glu Ser Gly Leu Gly 
            20                  25                  30          


Lys Ser Thr Leu Val Asn Ser Leu Phe Leu Thr 
        35                  40              


<210>  23
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ARTS N' terminal fragment residues 106-133

<400>  23

Val Gly Phe Ala Thr Leu Pro Asn Gln Val His Arg Lys Ser Val Lys 
1               5                   10                  15      


Lys Gly Phe Asp Phe Thr Leu Met Val Ala Gly Glu 
            20                  25              


<210>  24
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ARTS N' terminal fragment residues 106-128

<400>  24

Val Gly Phe Ala Thr Leu Pro Asn Gln Val His Arg Lys Ser Val Lys 
1               5                   10                  15      


Lys Gly Phe Asp Phe Thr Leu 
            20              


<210>  25
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ARTS N' terminal fragment residues 112-148

<400>  25

Pro Asn Gln Val His Arg Lys Ser Val Lys Lys Gly Phe Asp Phe Thr 
1               5                   10                  15      


Leu Met Val Ala Gly Glu Ser Gly Leu Gly Lys Ser Thr Leu Val Asn 
            20                  25                  30          


Ser Leu Phe Leu Thr 
        35          


<210>  26
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ARTS N' terminal fragment residues 112-133

<400>  26

Pro Asn Gln Val His Arg Lys Ser Val Lys Lys Gly Phe Asp Phe Thr 
1               5                   10                  15      


Leu Met Val Ala Gly Glu Ser Gly Leu Gly Lys Ser Thr Leu Val Asn 
            20                  25                  30          


Ser Leu Phe Leu Thr 
        35          


<210>  27
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ARTS N' terminal fragment 112-128

<400>  27

Pro Asn Gln Val His Arg Lys Ser Val Lys Lys Gly Phe Asp Phe Thr 
1               5                   10                  15      


Leu 
    


