                         SEQUENCE LISTING

<110>  Ultragenyx Pharmaceutical Inc.
       Kakkis, Emil D.
       Vellard, Michel Claude
       Swistowski, Andrzej
 
<120>  METHODS AND COMPOSITIONS FOR THE TREATMENT OF AMYLOIDOSIS

<130>  ULPI-034/01US

<150>  US 62/248,713
<151>  2015-10-30

<160>  72    

<170>  PatentIn version 3.5

<210>  1
<211>  2254
<212>  DNA
<213>  Homo sapiens

<400>  1
agagtgcacc cgaatccacg ggctcggagg cagcagccat ctctcggcca tagggcaggc       60

cagctggcgc cgggggctat tttgggcggc gggcaatgat ggtgaccgca aggcgacctt      120

gtaaggcatt tcccccctga ctcccttccc cgagcctctg cccgggggtc ctagcgccgc      180

tttctcagcc atcccgccta caacttagcc gtccacaaca ggatcatctg atcgcgtgcg      240

cccgggctac gatctgcgag gcccgcggac cttgacccgg cattgaccgc caccgccccc      300

caggtccgta gggaccaaag aaggggcggg aggaagactg tcacgtggcg ccggagttca      360

cgtgactcgt acacatgact tccagtcccc gggcgcctcc tggagagcaa ggacgcgggg      420

gagcagagat gatccgagcc gcgccgccgc cgctgttcct gctgctgctg ctgctgctgc      480

tgctagtgtc ctgggcgtcc cgaggcgagg cagcccccga ccaggacgag atccagcgcc      540

tccccgggct ggccaagcag ccgtctttcc gccagtactc cggctacctc aaaggctccg      600

gctccaagca cctccactac tggtttgtgg agtcccagaa ggatcccgag aacagccctg      660

tggtgctttg gctcaatggg ggtcccggct gcagctcact agatgggctc ctcacagagc      720

atggcccctt cctggtccag ccagatggtg tcaccctgga gtacaacccc tattcttgga      780

atctgattgc caatgtgtta tacctggagt ccccagctgg ggtgggcttc tcctactccg      840

atgacaagtt ttatgcaact aatgacactg aggtcgccca gagcaatttt gaggcccttc      900

aagatttctt ccgcctcttt ccggagtaca agaacaacaa acttttcctg accggggaga      960

gctatgctgg catctacatc cccaccctgg ccgtgctggt catgcaggat cccagcatga     1020

accttcaggg gctggctgtg ggcaatggac tctcctccta tgagcagaat gacaactccc     1080

tggtctactt tgcctactac catggccttc tggggaacag gctttggtct tctctccaga     1140

cccactgctg ctctcaaaac aagtgtaact tctatgacaa caaagacctg gaatgcgtga     1200

ccaatcttca ggaagtggcc cgcatcgtgg gcaactctgg cctcaacatc tacaatctct     1260

atgccccgtg tgctggaggg gtgcccagcc attttaggta tgagaaggac actgttgtgg     1320

tccaggattt gggcaacatc ttcactcgcc tgccactcaa gcggatgtgg catcaggcac     1380

tgctgcgctc aggggataaa gtgcgcatgg accccccctg caccaacaca acagctgctt     1440

ccacctacct caacaacccg tacgtgcgga aggccctcaa catcccggag cagctgccac     1500

aatgggacat gtgcaacttt ctggtaaact tacagtaccg ccgtctctac cgaagcatga     1560

actcccagta tctgaagctg cttagctcac agaaatacca gatcctatta tataatggag     1620

atgtagacat ggcctgcaat ttcatggggg atgagtggtt tgtggattcc ctcaaccaga     1680

agatggaggt gcagcgccgg ccctggttag tgaagtacgg ggacagcggg gagcagattg     1740

ccggcttcgt gaaggagttc tcccacatcg cctttctcac gatcaagggc gccggccaca     1800

tggttcccac cgacaagccc ctcgctgcct tcaccatgtt ctcccgcttc ctgaacaagc     1860

agccatactg atgaccacag caaccagctc cacggcctga tgcagcccct cccagcctct     1920

cccgctagga gagtcctctt ctaagcaaag tgcccctgca ggccgggttc tgccgccagg     1980

actgccccct tcccagagcc ctgtacatcc cagactgggc ccagggtctc ccatagacag     2040

cctgggggca agttagcact ttattcccgc agcagttcct gaatggggtg gcctggcccc     2100

ttctctgctt aaagaatgcc ctttatgatg cactgattcc atcccaggaa cccaacagag     2160

ctcaggacag cccacaggga ggtggtggac ggactgtaat tgatagattg attatggaat     2220

taaattgggt acagcttcaa aaaaaaaaaa aaaa                                 2254


<210>  2
<211>  498
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Thr Ser Ser Pro Arg Ala Pro Pro Gly Glu Gln Gly Arg Gly Gly 
1               5                   10                  15      


Ala Glu Met Ile Arg Ala Ala Pro Pro Pro Leu Phe Leu Leu Leu Leu 
            20                  25                  30          


Leu Leu Leu Leu Leu Val Ser Trp Ala Ser Arg Gly Glu Ala Ala Pro 
        35                  40                  45              


Asp Gln Asp Glu Ile Gln Arg Leu Pro Gly Leu Ala Lys Gln Pro Ser 
    50                  55                  60                  


Phe Arg Gln Tyr Ser Gly Tyr Leu Lys Gly Ser Gly Ser Lys His Leu 
65                  70                  75                  80  


His Tyr Trp Phe Val Glu Ser Gln Lys Asp Pro Glu Asn Ser Pro Val 
                85                  90                  95      


Val Leu Trp Leu Asn Gly Gly Pro Gly Cys Ser Ser Leu Asp Gly Leu 
            100                 105                 110         


Leu Thr Glu His Gly Pro Phe Leu Val Gln Pro Asp Gly Val Thr Leu 
        115                 120                 125             


Glu Tyr Asn Pro Tyr Ser Trp Asn Leu Ile Ala Asn Val Leu Tyr Leu 
    130                 135                 140                 


Glu Ser Pro Ala Gly Val Gly Phe Ser Tyr Ser Asp Asp Lys Phe Tyr 
145                 150                 155                 160 


Ala Thr Asn Asp Thr Glu Val Ala Gln Ser Asn Phe Glu Ala Leu Gln 
                165                 170                 175     


Asp Phe Phe Arg Leu Phe Pro Glu Tyr Lys Asn Asn Lys Leu Phe Leu 
            180                 185                 190         


Thr Gly Glu Ser Tyr Ala Gly Ile Tyr Ile Pro Thr Leu Ala Val Leu 
        195                 200                 205             


Val Met Gln Asp Pro Ser Met Asn Leu Gln Gly Leu Ala Val Gly Asn 
    210                 215                 220                 


Gly Leu Ser Ser Tyr Glu Gln Asn Asp Asn Ser Leu Val Tyr Phe Ala 
225                 230                 235                 240 


Tyr Tyr His Gly Leu Leu Gly Asn Arg Leu Trp Ser Ser Leu Gln Thr 
                245                 250                 255     


His Cys Cys Ser Gln Asn Lys Cys Asn Phe Tyr Asp Asn Lys Asp Leu 
            260                 265                 270         


Glu Cys Val Thr Asn Leu Gln Glu Val Ala Arg Ile Val Gly Asn Ser 
        275                 280                 285             


Gly Leu Asn Ile Tyr Asn Leu Tyr Ala Pro Cys Ala Gly Gly Val Pro 
    290                 295                 300                 


Ser His Phe Arg Tyr Glu Lys Asp Thr Val Val Val Gln Asp Leu Gly 
305                 310                 315                 320 


Asn Ile Phe Thr Arg Leu Pro Leu Lys Arg Met Trp His Gln Ala Leu 
                325                 330                 335     


Leu Arg Ser Gly Asp Lys Val Arg Met Asp Pro Pro Cys Thr Asn Thr 
            340                 345                 350         


Thr Ala Ala Ser Thr Tyr Leu Asn Asn Pro Tyr Val Arg Lys Ala Leu 
        355                 360                 365             


Asn Ile Pro Glu Gln Leu Pro Gln Trp Asp Met Cys Asn Phe Leu Val 
    370                 375                 380                 


Asn Leu Gln Tyr Arg Arg Leu Tyr Arg Ser Met Asn Ser Gln Tyr Leu 
385                 390                 395                 400 


Lys Leu Leu Ser Ser Gln Lys Tyr Gln Ile Leu Leu Tyr Asn Gly Asp 
                405                 410                 415     


Val Asp Met Ala Cys Asn Phe Met Gly Asp Glu Trp Phe Val Asp Ser 
            420                 425                 430         


Leu Asn Gln Lys Met Glu Val Gln Arg Arg Pro Trp Leu Val Lys Tyr 
        435                 440                 445             


Gly Asp Ser Gly Glu Gln Ile Ala Gly Phe Val Lys Glu Phe Ser His 
    450                 455                 460                 


Ile Ala Phe Leu Thr Ile Lys Gly Ala Gly His Met Val Pro Thr Asp 
465                 470                 475                 480 


Lys Pro Leu Ala Ala Phe Thr Met Phe Ser Arg Phe Leu Asn Lys Gln 
                485                 490                 495     


Pro Tyr 
        


<210>  3
<211>  2088
<212>  DNA
<213>  Homo sapiens

<400>  3
gagctacttg aagaccaatt agagtccggg aagcgcggcg gggcctccag accggggcgg       60

gcttaagggt gacatctgcg ctttaaaggg tccgggtcag ctgactcccg actctgtgga      120

gtctagctgc cagggtcgcg gcagctgcgg ggagagatga ctggggagcg acccagcacg      180

gcgctcccgg acagacgctg ggggccgcgg attctgggct tctggggagg ctgtagggtt      240

tgggtgtttg ccgcgatctt cctgctgctg tctctggcag cctcctggtc caaggctgag      300

aacgacttcg gtctggtgca gccgctggtg accatggagc aactgctgtg ggtgagcggg      360

agacagatcg gctcagtgga caccttccgc atcccgctca tcacagccac tccgcggggc      420

actcttctcg cctttgctga ggcgaggaaa atgtcctcat ccgatgaggg ggccaagttc      480

atcgccctgc ggaggtccat ggaccagggc agcacatggt ctcctacagc gttcattgtc      540

aatgatgggg atgtccccga tgggctgaac cttggggcag tagtgagcga tgttgagaca      600

ggagtagtat ttcttttcta ctccctttgt gctcacaagg ccggctgcca ggtggcctct      660

accatgttgg tatggagcaa ggatgatggt gtttcctgga gcacaccccg gaatctctcc      720

ctggatattg gcactgaagt gtttgcccct ggaccgggct ctggtattca gaaacagcgg      780

gagccacgga agggccgcct catcgtgtgt ggccatggga cgctggagcg ggacggagtc      840

ttctgtctcc tcagcgatga tcatggtgcc tcctggcgct acggaagtgg ggtcagcggc      900

atcccctacg gtcagcccaa gcaggaaaat gatttcaatc ctgatgaatg ccagccctat      960

gagctcccag atggctcagt cgtcatcaat gcccgaaacc agaacaacta ccactgccac     1020

tgccgaattg tcctccgcag ctatgatgcc tgtgatacac taaggccccg tgatgtgacc     1080

ttcgaccctg agctcgtgga ccctgtggta gctgcaggag ctgtagtcac cagctccggc     1140

attgtcttct tctccaaccc agcacatcca gagttccgag tgaacctgac cctgcgatgg     1200

agcttcagca atggtacctc atggcggaaa gagacagtcc agctatggcc aggccccagt     1260

ggctattcat ccctggcaac cctggagggc agcatggatg gagaggagca ggccccccag     1320

ctctacgtcc tgtatgagaa aggccggaac cactacacag agagcatctc cgtggccaaa     1380

atcagtgtct atgggacact ctgagctgtg ccactgccac aggggtattc tgccttcagg     1440

actctgcctt caggaacacg ggtctgtaga gggtctgctg gagacgcctg aaagacagtt     1500

ccatcttcct ttagactcca gccttggcaa aatcaccttc cctttaccag ggaaatcact     1560

tcctttagga ctgaaagcta ggcgtcctct cccacaaaaa agtcctgccc tcatctgaga     1620

atactgtctt tccatatggc taagtgtggc cccaccaccc tctctgccct cccgggacat     1680

tgattggtcc tgtcttgggc aggtctagtg agctgtagaa ttgaatcaat gtgaactcag     1740

ggaactgggg aaggctgagc ctcctctttg gtgttgcggt aagataaccg acagggctgg     1800

tgaaagtccc cagatggcag gatatttggt ttcagagtaa ggactaggtg caccaccatg     1860

actgactatc aatcaaaatg tttgtaactt aaaattttta atgaaggata atgaatattt     1920

gtagagtctc tatggttctg tcaatgcaca tcttcgtgtc tgttttcctc atgtatcctt     1980

gtgagcctgg gtgagttctg gggagagacc tgatgtgcgt actgcctgtg aaaatctgac     2040

tttggcaaat caaatcctct tttccttttg aaaaaaaaaa aaaaaaaa                  2088


<210>  4
<211>  415
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Thr Gly Glu Arg Pro Ser Thr Ala Leu Pro Asp Arg Arg Trp Gly 
1               5                   10                  15      


Pro Arg Ile Leu Gly Phe Trp Gly Gly Cys Arg Val Trp Val Phe Ala 
            20                  25                  30          


Ala Ile Phe Leu Leu Leu Ser Leu Ala Ala Ser Trp Ser Lys Ala Glu 
        35                  40                  45              


Asn Asp Phe Gly Leu Val Gln Pro Leu Val Thr Met Glu Gln Leu Leu 
    50                  55                  60                  


Trp Val Ser Gly Arg Gln Ile Gly Ser Val Asp Thr Phe Arg Ile Pro 
65                  70                  75                  80  


Leu Ile Thr Ala Thr Pro Arg Gly Thr Leu Leu Ala Phe Ala Glu Ala 
                85                  90                  95      


Arg Lys Met Ser Ser Ser Asp Glu Gly Ala Lys Phe Ile Ala Leu Arg 
            100                 105                 110         


Arg Ser Met Asp Gln Gly Ser Thr Trp Ser Pro Thr Ala Phe Ile Val 
        115                 120                 125             


Asn Asp Gly Asp Val Pro Asp Gly Leu Asn Leu Gly Ala Val Val Ser 
    130                 135                 140                 


Asp Val Glu Thr Gly Val Val Phe Leu Phe Tyr Ser Leu Cys Ala His 
145                 150                 155                 160 


Lys Ala Gly Cys Gln Val Ala Ser Thr Met Leu Val Trp Ser Lys Asp 
                165                 170                 175     


Asp Gly Val Ser Trp Ser Thr Pro Arg Asn Leu Ser Leu Asp Ile Gly 
            180                 185                 190         


Thr Glu Val Phe Ala Pro Gly Pro Gly Ser Gly Ile Gln Lys Gln Arg 
        195                 200                 205             


Glu Pro Arg Lys Gly Arg Leu Ile Val Cys Gly His Gly Thr Leu Glu 
    210                 215                 220                 


Arg Asp Gly Val Phe Cys Leu Leu Ser Asp Asp His Gly Ala Ser Trp 
225                 230                 235                 240 


Arg Tyr Gly Ser Gly Val Ser Gly Ile Pro Tyr Gly Gln Pro Lys Gln 
                245                 250                 255     


Glu Asn Asp Phe Asn Pro Asp Glu Cys Gln Pro Tyr Glu Leu Pro Asp 
            260                 265                 270         


Gly Ser Val Val Ile Asn Ala Arg Asn Gln Asn Asn Tyr His Cys His 
        275                 280                 285             


Cys Arg Ile Val Leu Arg Ser Tyr Asp Ala Cys Asp Thr Leu Arg Pro 
    290                 295                 300                 


Arg Asp Val Thr Phe Asp Pro Glu Leu Val Asp Pro Val Val Ala Ala 
305                 310                 315                 320 


Gly Ala Val Val Thr Ser Ser Gly Ile Val Phe Phe Ser Asn Pro Ala 
                325                 330                 335     


His Pro Glu Phe Arg Val Asn Leu Thr Leu Arg Trp Ser Phe Ser Asn 
            340                 345                 350         


Gly Thr Ser Trp Arg Lys Glu Thr Val Gln Leu Trp Pro Gly Pro Ser 
        355                 360                 365             


Gly Tyr Ser Ser Leu Ala Thr Leu Glu Gly Ser Met Asp Gly Glu Glu 
    370                 375                 380                 


Gln Ala Pro Gln Leu Tyr Val Leu Tyr Glu Lys Gly Arg Asn His Tyr 
385                 390                 395                 400 


Thr Glu Ser Ile Ser Val Ala Lys Ile Ser Val Tyr Gly Thr Leu 
                405                 410                 415 


<210>  5
<211>  3540
<212>  DNA
<213>  Homo sapiens

<400>  5
ggtggtggaa tatagagctc atgtgatccg tcacatgaca gcagatccgc ggaagggcag       60

aatgggactc caagcctgcc tcctagggct ctttgccctc atcctctctg gcaaatgcag      120

ttacagcccg gagcccgacc agcggaggac gctgccccca ggctgggtgt ccctgggccg      180

tgcggaccct gaggaagagc tgagtctcac ctttgccctg agacagcaga atgtggaaag      240

actctcggag ctggtgcagg ctgtgtcgga tcccagctct cctcaatacg gaaaatacct      300

gaccctagag aatgtggctg atctggtgag gccatcccca ctgaccctcc acacggtgca      360

aaaatggctc ttggcagccg gagcccagaa gtgccattct gtgatcacac aggactttct      420

gacttgctgg ctgagcatcc gacaagcaga gctgctgctc cctggggctg agtttcatca      480

ctatgtggga ggacctacgg aaacccatgt tgtaaggtcc ccacatccct accagcttcc      540

acaggccttg gccccccatg tggactttgt ggggggactg caccgttttc ccccaacatc      600

atccctgagg caacgtcctg agccgcaggt gacagggact gtaggcctgc atctgggggt      660

aaccccctct gtgatccgta agcgatacaa cttgacctca caagacgtgg gctctggcac      720

cagcaataac agccaagcct gtgcccagtt cctggagcag tatttccatg actcagacct      780

ggctcagttc atgcgcctct tcggtggcaa ctttgcacat caggcatcag tagcccgtgt      840

ggttggacaa cagggccggg gccgggccgg gattgaggcc agtctagatg tgcagtacct      900

gatgagtgct ggtgccaaca tctccacctg ggtctacagt agccctggcc ggcatgaggg      960

acaggagccc ttcctgcagt ggctcatgct gctcagtaat gagtcagccc tgccacatgt     1020

gcatactgtg agctatggag atgatgagga ctccctcagc agcgcctaca tccagcgggt     1080

caacactgag ctcatgaagg ctgccgctcg gggtctcacc ctgctcttcg cctcaggtga     1140

cagtggggcc gggtgttggt ctgtctctgg aagacaccag ttccgcccta ccttccctgc     1200

ctccagcccc tatgtcacca cagtgggagg cacatccttc caggaacctt tcctcatcac     1260

aaatgaaatt gttgactata tcagtggtgg tggcttcagc aatgtgttcc cacggccttc     1320

ataccaggag gaagctgtaa cgaagttcct gagctctagc ccccacctgc caccatccag     1380

ttacttcaat gccagtggcc gtgcctaccc agatgtggct gcactttctg atggctactg     1440

ggtggtcagc aacagagtgc ccattccatg ggtgtccgga acctcggcct ctactccagt     1500

gtttgggggg atcctatcct tgatcaatga gcacaggatc cttagtggcc gcccccctct     1560

tggctttctc aacccaaggc tctaccagca gcatggggca ggactctttg atgtaacccg     1620

tggctgccat gagtcctgtc tggatgaaga ggtagagggc cagggtttct gctctggtcc     1680

tggctgggat cctgtaacag gctggggaac acccaacttc ccagctttgc tgaagactct     1740

actcaacccc tgaccctttc ctatcaggag agatggcttg tcccctgccc tgaagctggc     1800

agttcagtcc cttattctgc cctgttggaa gccctgctga accctcaact attgactgct     1860

gcagacagct tatctcccta accctgaaat gctgtgagct tgacttgact cccaacccta     1920

ccatgctcca tcatactcag gtctccctac tcctgcctta gattcctcaa taagatgctg     1980

taactagcat tttttgaatg cctctccctc cgcatctcat ctttctcttt tcaatcaggc     2040

ttttccaaag ggttgtatac agactctgtg cactatttca cttgatattc attccccaat     2100

tcactgcaag gagacctcta ctgtcaccgt ttactctttc ctaccctgac atccagaaac     2160

aatggcctcc agtgcatact tctcaatctt tgctttatgg cctttccatc atagttgccc     2220

actccctctc cttacttagc ttccaggtct taacttctct gactactctt gtcttcctct     2280

ctcatcaatt tctgcttctt catggaatgc tgaccttcat tgctccattt gtagattttt     2340

gctcttctca gtttactcat tgtcccctgg aacaaatcac tgacatctac aaccattacc     2400

atctcactaa ataagacttt ctatccaata atgattgata cctcaaatgt aagatgcgtg     2460

atactcaaca tttcatcgtc caccttccca accccaaaca attccatctc gtttcttctt     2520

ggtaaatgat gctatgcttt ttccaaccaa gccagaaacc tgtgtcatct tttcacccca     2580

ccttcaatca acaagtcctc aatcaacaag tcctactgac tgcacatctt aaatatatct     2640

ttatcagtcc acaagtcctt ccaattatat ttcccaagta tatctagaac ttatccactt     2700

atatccccac tgctactacc ttagtttagg gctatattct cttgaaaaaa agtgtcctta     2760

cttcctgcca atccccaagt catcttccag agtaaaatgc aaatcccatc aggccacttg     2820

gatgaaaacc cttcaaggat tactggatag aattcaggct ttcccctcca gcccccaatc     2880

atagctcaca aaccttcctt gctatttgtt cttaagtaaa aaatcatttt tcctcctccc     2940

tccccaaacc ccaaggaact ctcactcttg ctcaagctgt tccgtcccct taccacccct     3000

gatacaactg ccaggttaat ttccagaatt cttgcaagac tcagttcaga agtcaccttc     3060

tttcgtgaat gttttgattc cctgaggcta ctttattttg gtatggctga aaaatcctag     3120

attttctaaa caaaacctgt ttgaatcttg gttctgatat ggactaggag agagactggg     3180

tcaagtaagc ttatctccct gaggctgttt cctcgtctgt taagtgtgaa tatcaatacc     3240

tgcctttcat aatcaccagg gaataaagtg gaataatgtt gataacagtg cttggcacct     3300

ggaagtaggt ggcagatgtt aacgcccttc ctcccttgca ctgcgccccc tgtgcctacc     3360

tctagcattg taacgaccac gtagtattga aatggccagt ttacttgtct gccttccttt     3420

ccaagaccgt tggtgcctag aggactagaa tcgtgtccta tttaactttg tgttcccagg     3480

tcctagctca ggagttggca aataagaatt aaatgtctgc tacaccgaaa accaaaaaaa     3540


<210>  6
<211>  563
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Gly Leu Gln Ala Cys Leu Leu Gly Leu Phe Ala Leu Ile Leu Ser 
1               5                   10                  15      


Gly Lys Cys Ser Tyr Ser Pro Glu Pro Asp Gln Arg Arg Thr Leu Pro 
            20                  25                  30          


Pro Gly Trp Val Ser Leu Gly Arg Ala Asp Pro Glu Glu Glu Leu Ser 
        35                  40                  45              


Leu Thr Phe Ala Leu Arg Gln Gln Asn Val Glu Arg Leu Ser Glu Leu 
    50                  55                  60                  


Val Gln Ala Val Ser Asp Pro Ser Ser Pro Gln Tyr Gly Lys Tyr Leu 
65                  70                  75                  80  


Thr Leu Glu Asn Val Ala Asp Leu Val Arg Pro Ser Pro Leu Thr Leu 
                85                  90                  95      


His Thr Val Gln Lys Trp Leu Leu Ala Ala Gly Ala Gln Lys Cys His 
            100                 105                 110         


Ser Val Ile Thr Gln Asp Phe Leu Thr Cys Trp Leu Ser Ile Arg Gln 
        115                 120                 125             


Ala Glu Leu Leu Leu Pro Gly Ala Glu Phe His His Tyr Val Gly Gly 
    130                 135                 140                 


Pro Thr Glu Thr His Val Val Arg Ser Pro His Pro Tyr Gln Leu Pro 
145                 150                 155                 160 


Gln Ala Leu Ala Pro His Val Asp Phe Val Gly Gly Leu His Arg Phe 
                165                 170                 175     


Pro Pro Thr Ser Ser Leu Arg Gln Arg Pro Glu Pro Gln Val Thr Gly 
            180                 185                 190         


Thr Val Gly Leu His Leu Gly Val Thr Pro Ser Val Ile Arg Lys Arg 
        195                 200                 205             


Tyr Asn Leu Thr Ser Gln Asp Val Gly Ser Gly Thr Ser Asn Asn Ser 
    210                 215                 220                 


Gln Ala Cys Ala Gln Phe Leu Glu Gln Tyr Phe His Asp Ser Asp Leu 
225                 230                 235                 240 


Ala Gln Phe Met Arg Leu Phe Gly Gly Asn Phe Ala His Gln Ala Ser 
                245                 250                 255     


Val Ala Arg Val Val Gly Gln Gln Gly Arg Gly Arg Ala Gly Ile Glu 
            260                 265                 270         


Ala Ser Leu Asp Val Gln Tyr Leu Met Ser Ala Gly Ala Asn Ile Ser 
        275                 280                 285             


Thr Trp Val Tyr Ser Ser Pro Gly Arg His Glu Gly Gln Glu Pro Phe 
    290                 295                 300                 


Leu Gln Trp Leu Met Leu Leu Ser Asn Glu Ser Ala Leu Pro His Val 
305                 310                 315                 320 


His Thr Val Ser Tyr Gly Asp Asp Glu Asp Ser Leu Ser Ser Ala Tyr 
                325                 330                 335     


Ile Gln Arg Val Asn Thr Glu Leu Met Lys Ala Ala Ala Arg Gly Leu 
            340                 345                 350         


Thr Leu Leu Phe Ala Ser Gly Asp Ser Gly Ala Gly Cys Trp Ser Val 
        355                 360                 365             


Ser Gly Arg His Gln Phe Arg Pro Thr Phe Pro Ala Ser Ser Pro Tyr 
    370                 375                 380                 


Val Thr Thr Val Gly Gly Thr Ser Phe Gln Glu Pro Phe Leu Ile Thr 
385                 390                 395                 400 


Asn Glu Ile Val Asp Tyr Ile Ser Gly Gly Gly Phe Ser Asn Val Phe 
                405                 410                 415     


Pro Arg Pro Ser Tyr Gln Glu Glu Ala Val Thr Lys Phe Leu Ser Ser 
            420                 425                 430         


Ser Pro His Leu Pro Pro Ser Ser Tyr Phe Asn Ala Ser Gly Arg Ala 
        435                 440                 445             


Tyr Pro Asp Val Ala Ala Leu Ser Asp Gly Tyr Trp Val Val Ser Asn 
    450                 455                 460                 


Arg Val Pro Ile Pro Trp Val Ser Gly Thr Ser Ala Ser Thr Pro Val 
465                 470                 475                 480 


Phe Gly Gly Ile Leu Ser Leu Ile Asn Glu His Arg Ile Leu Ser Gly 
                485                 490                 495     


Arg Pro Pro Leu Gly Phe Leu Asn Pro Arg Leu Tyr Gln Gln His Gly 
            500                 505                 510         


Ala Gly Leu Phe Asp Val Thr Arg Gly Cys His Glu Ser Cys Leu Asp 
        515                 520                 525             


Glu Glu Val Glu Gly Gln Gly Phe Cys Ser Gly Pro Gly Trp Asp Pro 
    530                 535                 540                 


Val Thr Gly Trp Gly Thr Pro Asn Phe Pro Ala Leu Leu Lys Thr Leu 
545                 550                 555                 560 


Leu Asn Pro 
            


<210>  7
<211>  3783
<212>  DNA
<213>  Homo sapiens

<400>  7
ggggcggggc cgggagggta cttagggccg gggctggccc aggctacggc ggctgcaggg       60

ctccggcaac cgctccggca acgccaaccg ctccgctgcg cgcaggctgg gctgcaggct      120

ctcggctgca gcgctgggtg gatctaggat ccggcttcca acatgtggca gctctgggcc      180

tccctctgct gcctgctggt gttggccaat gcccggagca ggccctcttt ccatcccctg      240

tcggatgagc tggtcaacta tgtcaacaaa cggaatacca cgtggcaggc cgggcacaac      300

ttctacaacg tggacatgag ctacttgaag aggctatgtg gtaccttcct gggtgggccc      360

aagccacccc agagagttat gtttaccgag gacctgaagc tgcctgcaag cttcgatgca      420

cgggaacaat ggccacagtg tcccaccatc aaagagatca gagaccaggg ctcctgtggc      480

tcctgctggg ccttcggggc tgtggaagcc atctctgacc ggatctgcat ccacaccaat      540

gcgcacgtca gcgtggaggt gtcggcggag gacctgctca catgctgtgg cagcatgtgt      600

ggggacggct gtaatggtgg ctatcctgct gaagcttgga acttctggac aagaaaaggc      660

ctggtttctg gtggcctcta tgaatcccat gtagggtgca gaccgtactc catccctccc      720

tgtgagcacc acgtcaacgg ctcccggccc ccatgcacgg gggagggaga tacccccaag      780

tgtagcaaga tctgtgagcc tggctacagc ccgacctaca aacaggacaa gcactacgga      840

tacaattcct acagcgtctc caatagcgag aaggacatca tggccgagat ctacaaaaac      900

ggccccgtgg agggagcttt ctctgtgtat tcggacttcc tgctctacaa gtcaggagtg      960

taccaacacg tcaccggaga gatgatgggt ggccatgcca tccgcatcct gggctgggga     1020

gtggagaatg gcacacccta ctggctggtt gccaactcct ggaacactga ctggggtgac     1080

aatggcttct ttaaaatact cagaggacag gatcactgtg gaatcgaatc agaagtggtg     1140

gctggaattc cacgcaccga tcagtactgg gaaaagatct aatctgccgt gggcctgtcg     1200

tgccagtcct gggggcgaga tcggggtaga aatgcatttt attctttaag ttcacgtaag     1260

atacaagttt cagacagggt ctgaaggact ggattggcca aacatcagac ctgtcttcca     1320

aggagaccaa gtcctggcta catcccagcc tgtggttaca gtgcagacag gccatgtgag     1380

ccaccgctgc cagcacagag cgtccttccc cctgtagact agtgccgtag ggagtacctg     1440

ctgccccagc tgactgtggc cccctccgtg atccatccat ctccagggag caagacagag     1500

acgcaggaat ggaaagcgga gttcctaaca ggatgaaagt tcccccatca gttcccccag     1560

tacctccaag caagtagctt tccacatttg tcacagaaat cagaggagag acggtgttgg     1620

gagccctttg gagaacgcca gtctcccagg ccccctgcat ctatcgagtt tgcaatgtca     1680

caacctctct gatcttgtgc tcagcatgat tctttaatag aagttttatt ttttcgtgca     1740

ctctgctaat catgtgggtg agccagtgga acagcgggag acctgtgcta gttttacaga     1800

ttgcctcctt atgacgcggc tcaaaaggaa accaagtggt caggagttgt ttctgaccca     1860

ctgatctcta ctaccacaag gaaaatagtt taggagaaac cagcttttac tgtttttgaa     1920

aaattacagc ttcaccctgt caagttaaca aggaatgcct gtgccaataa aagttttctc     1980

caacttgaag tctactctga tgggatctca gatcctttgt cactgcctat agacttgtag     2040

ctgctgtctc tctttgtccc tgcagagaat cacgtcctgg aactgcatgt tcttgcgact     2100

cttgggactt catcttaact tctcgctgcc ccagccatgt tttcaaccat ggcatccctc     2160

ccccaattag ttccctgtca tcctcgtcaa ccttctctgt aagtgcctgg taagcttgcc     2220

cttgcttaag aactcaaaac atagctgtgc tctatttttt tgttgttgtt gtgactgaca     2280

gagtgagatt ccgtctccca ggctggagtg cagtggcgcc ttctcagctc actgcaacct     2340

gcagcctcct agattcaagc gattctcctg cttcagcctt ccgagtagct gggatgacag     2400

gcactcacca atatgcctgg gtaatttttg tatttttaag tacatacagg atttcaccat     2460

gttggccagg ctagtttcaa actcccggcc tcaggtggtc tgcctgcctc agcctcccaa     2520

agtgttggga ttacaggcgt gagccactgg gccctgcctg tattttttat cagccacaaa     2580

tccagcaaca agctgaggat tcagctcata aaacaggctt ggtgtcttgg tgatctcaca     2640

taaccaagat gctaccccgt ggggaaccac atccccctgg atgccctcca gccttggttt     2700

gggctggagt cagggcctgt atacagtatt ttgaatttgt atgccactgg tttgcattgc     2760

tggtcaggaa ctctagtgct ttgcatagcc ctggtttaga aacatgttat agcagttctt     2820

ggtatagagc aaactagaag aaccagcaat cattccactg tcctgccaag gtacacctca     2880

gtactcccct tcccaactga agtggtatga ggctagctct ttccaaaagc attcaagttt     2940

ggcttctgat gtgactcaga atttaggaac cagatgctag atcaaataag ctctgaaaat     3000

ctgaggaaca ttgtaggaaa ggtttgttaa gcatctctta agtgccatga tgagcataac     3060

agccggccgt cgtggctcac gcctgtaatc ccagcacttt gggaggccaa ggtgggagga     3120

tgacaaggtc aggagttcaa gaccagcctg gccaacatgc tgaaacctca cctctactaa     3180

aaatacaaaa attagctggg catggtggca catgcctgta atcccagcta cttgggaggc     3240

tgaggcagga gaatcgcttg aacccgggag gcggaggttg cagtgagcca agacagtgcc     3300

agtgcactcc agcctcggtg acagcgcaag gctccgtctc aataattaaa aaaaaaaaaa     3360

aaaaaaaaaa ggccgggcgc agtggctcaa gcctgtaatc ccagcacttt gggaggctga     3420

ggcgggcaga tcacctgagg tcaggagttt tgagatcagc cttggcaaca cggtgaaacc     3480

ccatctctac taaaaataca aaattagcca agcatgctgg cacatgcctg taatcccagc     3540

tactcgggag gctgaggtac gagaatcgct tgaacctggg aggcagagga tgcagtgagc     3600

cgagatcacg ccattgcact ccagcctggg ggacaagagt gaatctgtgt ctcaccaaaa     3660

aaaaaaagaa aaagaaagat gcttaacaaa ggttaccata agccacaaat tcataaccac     3720

ttatccttcc agtttcaagt agaatatatt cataacctca ataaagttct ccctgctccc     3780

aaa                                                                   3783


<210>  8
<211>  339
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Trp Gln Leu Trp Ala Ser Leu Cys Cys Leu Leu Val Leu Ala Asn 
1               5                   10                  15      


Ala Arg Ser Arg Pro Ser Phe His Pro Leu Ser Asp Glu Leu Val Asn 
            20                  25                  30          


Tyr Val Asn Lys Arg Asn Thr Thr Trp Gln Ala Gly His Asn Phe Tyr 
        35                  40                  45              


Asn Val Asp Met Ser Tyr Leu Lys Arg Leu Cys Gly Thr Phe Leu Gly 
    50                  55                  60                  


Gly Pro Lys Pro Pro Gln Arg Val Met Phe Thr Glu Asp Leu Lys Leu 
65                  70                  75                  80  


Pro Ala Ser Phe Asp Ala Arg Glu Gln Trp Pro Gln Cys Pro Thr Ile 
                85                  90                  95      


Lys Glu Ile Arg Asp Gln Gly Ser Cys Gly Ser Cys Trp Ala Phe Gly 
            100                 105                 110         


Ala Val Glu Ala Ile Ser Asp Arg Ile Cys Ile His Thr Asn Ala His 
        115                 120                 125             


Val Ser Val Glu Val Ser Ala Glu Asp Leu Leu Thr Cys Cys Gly Ser 
    130                 135                 140                 


Met Cys Gly Asp Gly Cys Asn Gly Gly Tyr Pro Ala Glu Ala Trp Asn 
145                 150                 155                 160 


Phe Trp Thr Arg Lys Gly Leu Val Ser Gly Gly Leu Tyr Glu Ser His 
                165                 170                 175     


Val Gly Cys Arg Pro Tyr Ser Ile Pro Pro Cys Glu His His Val Asn 
            180                 185                 190         


Gly Ser Arg Pro Pro Cys Thr Gly Glu Gly Asp Thr Pro Lys Cys Ser 
        195                 200                 205             


Lys Ile Cys Glu Pro Gly Tyr Ser Pro Thr Tyr Lys Gln Asp Lys His 
    210                 215                 220                 


Tyr Gly Tyr Asn Ser Tyr Ser Val Ser Asn Ser Glu Lys Asp Ile Met 
225                 230                 235                 240 


Ala Glu Ile Tyr Lys Asn Gly Pro Val Glu Gly Ala Phe Ser Val Tyr 
                245                 250                 255     


Ser Asp Phe Leu Leu Tyr Lys Ser Gly Val Tyr Gln His Val Thr Gly 
            260                 265                 270         


Glu Met Met Gly Gly His Ala Ile Arg Ile Leu Gly Trp Gly Val Glu 
        275                 280                 285             


Asn Gly Thr Pro Tyr Trp Leu Val Ala Asn Ser Trp Asn Thr Asp Trp 
    290                 295                 300                 


Gly Asp Asn Gly Phe Phe Lys Ile Leu Arg Gly Gln Asp His Cys Gly 
305                 310                 315                 320 


Ile Glu Ser Glu Val Val Ala Gly Ile Pro Arg Thr Asp Gln Tyr Trp 
                325                 330                 335     


Glu Lys Ile 
            


<210>  9
<211>  1825
<212>  DNA
<213>  Homo sapiens

<400>  9
acacatgctg catacacaca gaaacactgc aaatccactg cctccttccc tcctccctac       60

ccttccttct ctcagcattt ctatccccgc ctcctcctct tacccaaatt ttccagccga      120

tcactggagc tgacttccgc aatcccgatg gaataaatct agcacccctg atggtgtgcc      180

cacactttgc tgccgaaacg aagccagaca acagatttcc atcagcagga tgtgggggct      240

caaggttctg ctgctacctg tggtgagctt tgctctgtac cctgaggaga tactggacac      300

ccactgggag ctatggaaga agacccacag gaagcaatat aacaacaagg tggatgaaat      360

ctctcggcgt ttaatttggg aaaaaaacct gaagtatatt tccatccata accttgaggc      420

ttctcttggt gtccatacat atgaactggc tatgaaccac ctgggggaca tgaccagtga      480

agaggtggtt cagaagatga ctggactcaa agtacccctg tctcattccc gcagtaatga      540

caccctttat atcccagaat gggaaggtag agccccagac tctgtcgact atcgaaagaa      600

aggatatgtt actcctgtca aaaatcaggg tcagtgtggt tcctgttggg cttttagctc      660

tgtgggtgcc ctggagggcc aactcaagaa gaaaactggc aaactcttaa atctgagtcc      720

ccagaaccta gtggattgtg tgtctgagaa tgatggctgt ggagggggct acatgaccaa      780

tgccttccaa tatgtgcaga agaaccgggg tattgactct gaagatgcct acccatatgt      840

gggacaggaa gagagttgta tgtacaaccc aacaggcaag gcagctaaat gcagagggta      900

cagagagatc cccgagggga atgagaaagc cctgaagagg gcagtggccc gagtgggacc      960

tgtctctgtg gccattgatg caagcctgac ctccttccag ttttacagca aaggtgtgta     1020

ttatgatgaa agctgcaata gcgataatct gaaccatgcg gttttggcag tgggatatgg     1080

aatccagaag ggaaacaagc actggataat taaaaacagc tggggagaaa actggggaaa     1140

caaaggatat atcctcatgg ctcgaaataa gaacaacgcc tgtggcattg ccaacctggc     1200

cagcttcccc aagatgtgac tccagccagc caaatccatc ctgctcttcc atttcttcca     1260

cgatggtgca gtgtaacgat gcactttgga agggagttgg tgtgctattt ttgaagcaga     1320

tgtggtgata ctgagattgt ctgttcagtt tccccatttg tttgtgcttc aaatgatcct     1380

tcctactttg cttctctcca cccatgacct ttttcactgt ggccatcagg actttccctg     1440

acagctgtgt actcttaggc taagagatgt gactacagcc tgcccctgac tgtgttgtcc     1500

cagggctgat gctgtacagg tacaggctgg agattttcac ataggttaga ttctcattca     1560

cgggactagt tagctttaag caccctagag gactagggta atctgacttc tcacttccta     1620

agttcccttc tatatcctca aggtagaaat gtctatgttt tctactccaa ttcataaatc     1680

tattcataag tctttggtac aagtttacat gataaaaaga aatgtgattt gtcttccctt     1740

ctttgcactt ttgaaataaa gtatttatct cctgtctaca gtttaataaa tagcatctag     1800

tacacattca aaaaaaaaaa aaaaa                                           1825


<210>  10
<211>  329
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Trp Gly Leu Lys Val Leu Leu Leu Pro Val Val Ser Phe Ala Leu 
1               5                   10                  15      


Tyr Pro Glu Glu Ile Leu Asp Thr His Trp Glu Leu Trp Lys Lys Thr 
            20                  25                  30          


His Arg Lys Gln Tyr Asn Asn Lys Val Asp Glu Ile Ser Arg Arg Leu 
        35                  40                  45              


Ile Trp Glu Lys Asn Leu Lys Tyr Ile Ser Ile His Asn Leu Glu Ala 
    50                  55                  60                  


Ser Leu Gly Val His Thr Tyr Glu Leu Ala Met Asn His Leu Gly Asp 
65                  70                  75                  80  


Met Thr Ser Glu Glu Val Val Gln Lys Met Thr Gly Leu Lys Val Pro 
                85                  90                  95      


Leu Ser His Ser Arg Ser Asn Asp Thr Leu Tyr Ile Pro Glu Trp Glu 
            100                 105                 110         


Gly Arg Ala Pro Asp Ser Val Asp Tyr Arg Lys Lys Gly Tyr Val Thr 
        115                 120                 125             


Pro Val Lys Asn Gln Gly Gln Cys Gly Ser Cys Trp Ala Phe Ser Ser 
    130                 135                 140                 


Val Gly Ala Leu Glu Gly Gln Leu Lys Lys Lys Thr Gly Lys Leu Leu 
145                 150                 155                 160 


Asn Leu Ser Pro Gln Asn Leu Val Asp Cys Val Ser Glu Asn Asp Gly 
                165                 170                 175     


Cys Gly Gly Gly Tyr Met Thr Asn Ala Phe Gln Tyr Val Gln Lys Asn 
            180                 185                 190         


Arg Gly Ile Asp Ser Glu Asp Ala Tyr Pro Tyr Val Gly Gln Glu Glu 
        195                 200                 205             


Ser Cys Met Tyr Asn Pro Thr Gly Lys Ala Ala Lys Cys Arg Gly Tyr 
    210                 215                 220                 


Arg Glu Ile Pro Glu Gly Asn Glu Lys Ala Leu Lys Arg Ala Val Ala 
225                 230                 235                 240 


Arg Val Gly Pro Val Ser Val Ala Ile Asp Ala Ser Leu Thr Ser Phe 
                245                 250                 255     


Gln Phe Tyr Ser Lys Gly Val Tyr Tyr Asp Glu Ser Cys Asn Ser Asp 
            260                 265                 270         


Asn Leu Asn His Ala Val Leu Ala Val Gly Tyr Gly Ile Gln Lys Gly 
        275                 280                 285             


Asn Lys His Trp Ile Ile Lys Asn Ser Trp Gly Glu Asn Trp Gly Asn 
    290                 295                 300                 


Lys Gly Tyr Ile Leu Met Ala Arg Asn Lys Asn Asn Ala Cys Gly Ile 
305                 310                 315                 320 


Ala Asn Leu Ala Ser Phe Pro Lys Met 
                325                 


<210>  11
<211>  1730
<212>  DNA
<213>  Homo sapiens

<400>  11
ggcggtgccg gccgaaccca gacccgaggt tttagaagca gagtcaggcg aagctgggcc       60

agaaccgcga cctccgcaac cttgagcggc atccgtggag tgcgcctgcg cagctacgac      120

cgcagcagga aagcgccgcc ggccaggccc agctgtggcc ggacagggac tggaagagag      180

gacgcggtcg agtaggtgtg caccagccct ggcaacgaga gcgtctaccc cgaactctgc      240

tggccttgag gtggggaagc cggggagggc agttgaggac cccgcggagg cgcgtgactg      300

gttgagcggg caggccagcc tccgagccgg gtggacacag gttttaaaac atgaatccta      360

cactcatcct tgctgccttt tgcctgggaa ttgcctcagc tactctaaca tttgatcaca      420

gtttagaggc acagtggacc aagtggaagg cgatgcacaa cagattatac ggcatgaatg      480

aagaaggatg gaggagagca gtgtgggaga agaacatgaa gatgattgaa ctgcacaatc      540

aggaatacag ggaagggaaa cacagcttca caatggccat gaacgccttt ggagacatga      600

ccagtgaaga attcaggcag gtgatgaatg gctttcaaaa ccgtaagccc aggaagggga      660

aagtgttcca ggaacctctg ttttatgagg cccccagatc tgtggattgg agagagaaag      720

gctacgtgac tcctgtgaag aatcagggtc agtgtggttc ttgttgggct tttagtgcta      780

ctggtgctct tgaaggacag atgttccgga aaactgggag gcttatctca ctgagtgagc      840

agaatctggt agactgctct gggcctcaag gcaatgaagg ctgcaatggt ggcctaatgg      900

attatgcttt ccagtatgtt caggataatg gaggcctgga ctctgaggaa tcctatccat      960

atgaggcaac agaagaatcc tgtaagtaca atcccaagta ttctgttgct aatgacaccg     1020

gctttgtgga catccctaag caggagaagg ccctgatgaa ggcagttgca actgtggggc     1080

ccatttctgt tgctattgat gcaggtcatg agtccttcct gttctataaa gaaggcattt     1140

attttgagcc agactgtagc agtgaagaca tggatcatgg tgtgctggtg gttggctacg     1200

gatttgaaag cacagaatca gataacaata aatattggct ggtgaagaac agctggggtg     1260

aagaatgggg catgggtggc tacgtaaaga tggccaaaga ccggagaaac cattgtggaa     1320

ttgcctcagc agccagctac cccactgtgt gagctggtgg acggtgatga ggaaggactt     1380

gactggggat ggcgcatgca tgggaggaat tcatcttcag tctaccagcc cccgctgtgt     1440

cggatacaca ctcgaatcat tgaagatccg agtgtgattt gaattctgtg atattttcac     1500

actggtaaat gttacctcta ttttaattac tgctataaat aggtttatat tattgattca     1560

cttactgact ttgcattttc gtttttaaaa ggatgtataa atttttacct gtttaaataa     1620

aatttaattt caaatgtagt ggtggggctt ctttctattt ttgatgcact gaatttttgt     1680

gtaataaaga acataattgg gctctaagcc ataaaaaaaa aaaaaaaaaa                1730


<210>  12
<211>  333
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Asn Pro Thr Leu Ile Leu Ala Ala Phe Cys Leu Gly Ile Ala Ser 
1               5                   10                  15      


Ala Thr Leu Thr Phe Asp His Ser Leu Glu Ala Gln Trp Thr Lys Trp 
            20                  25                  30          


Lys Ala Met His Asn Arg Leu Tyr Gly Met Asn Glu Glu Gly Trp Arg 
        35                  40                  45              


Arg Ala Val Trp Glu Lys Asn Met Lys Met Ile Glu Leu His Asn Gln 
    50                  55                  60                  


Glu Tyr Arg Glu Gly Lys His Ser Phe Thr Met Ala Met Asn Ala Phe 
65                  70                  75                  80  


Gly Asp Met Thr Ser Glu Glu Phe Arg Gln Val Met Asn Gly Phe Gln 
                85                  90                  95      


Asn Arg Lys Pro Arg Lys Gly Lys Val Phe Gln Glu Pro Leu Phe Tyr 
            100                 105                 110         


Glu Ala Pro Arg Ser Val Asp Trp Arg Glu Lys Gly Tyr Val Thr Pro 
        115                 120                 125             


Val Lys Asn Gln Gly Gln Cys Gly Ser Cys Trp Ala Phe Ser Ala Thr 
    130                 135                 140                 


Gly Ala Leu Glu Gly Gln Met Phe Arg Lys Thr Gly Arg Leu Ile Ser 
145                 150                 155                 160 


Leu Ser Glu Gln Asn Leu Val Asp Cys Ser Gly Pro Gln Gly Asn Glu 
                165                 170                 175     


Gly Cys Asn Gly Gly Leu Met Asp Tyr Ala Phe Gln Tyr Val Gln Asp 
            180                 185                 190         


Asn Gly Gly Leu Asp Ser Glu Glu Ser Tyr Pro Tyr Glu Ala Thr Glu 
        195                 200                 205             


Glu Ser Cys Lys Tyr Asn Pro Lys Tyr Ser Val Ala Asn Asp Thr Gly 
    210                 215                 220                 


Phe Val Asp Ile Pro Lys Gln Glu Lys Ala Leu Met Lys Ala Val Ala 
225                 230                 235                 240 


Thr Val Gly Pro Ile Ser Val Ala Ile Asp Ala Gly His Glu Ser Phe 
                245                 250                 255     


Leu Phe Tyr Lys Glu Gly Ile Tyr Phe Glu Pro Asp Cys Ser Ser Glu 
            260                 265                 270         


Asp Met Asp His Gly Val Leu Val Val Gly Tyr Gly Phe Glu Ser Thr 
        275                 280                 285             


Glu Ser Asp Asn Asn Lys Tyr Trp Leu Val Lys Asn Ser Trp Gly Glu 
    290                 295                 300                 


Glu Trp Gly Met Gly Gly Tyr Val Lys Met Ala Lys Asp Arg Arg Asn 
305                 310                 315                 320 


His Cys Gly Ile Ala Ser Ala Ala Ser Tyr Pro Thr Val 
                325                 330             


<210>  13
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  signal peptide


<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  Xaa can be any naturally occurring amino acid

<400>  13

Asp Xaa Xaa Leu Leu 
1               5   


<210>  14
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  signal peptide


<220>
<221>  misc_feature
<222>  (3)..(5)
<223>  Xaa can be any naturally occurring amino acid

<400>  14

Asp Glu Xaa Xaa Xaa Leu Leu Ile 
1               5               


<210>  15
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  signal peptide


<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa may be an amino acid with a bulky hydrophobic side chain, 
       such as Ile, Phe, Leu, Val, and Met

<400>  15

Tyr Xaa Xaa Xaa 
1               


<210>  16
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  signal peptide

<400>  16

Ser Phe His Asp Asp Ser Asp Glu Asp Leu Leu 
1               5                   10      


<210>  17
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  signal peptide

<400>  17

Glu Glu Ser Glu Glu Arg Asp Asp His Leu Leu 
1               5                   10      


<210>  18
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  signal peptide

<400>  18

Gly Tyr His Asp Asp Ser Asp Glu Asp Leu Leu 
1               5                   10      


<210>  19
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  signal peptide

<400>  19

Ile Thr Gly Phe Ser Asp Asp Val Pro Met Val 
1               5                   10      


<210>  20
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  signal peptide

<400>  20

Ala Ser Val Ser Leu Leu Asp Asp Glu Leu Met 
1               5                   10      


<210>  21
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  signal peptide

<400>  21

Ala Ser Ser Gly Leu Asp Asp Leu Asp Leu Leu 
1               5                   10      


<210>  22
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  signal peptide

<400>  22

Val Gln Asn Pro Ser Ala Asp Arg Asn Leu Leu 
1               5                   10      


<210>  23
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  signal peptide

<400>  23

Asn Ala Leu Ser Trp Leu Asp Glu Glu Leu Leu 
1               5                   10      


<210>  24
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  signal peptide

<400>  24

Asp Glu Arg Ala Pro Leu Ile 
1               5           


<210>  25
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  signal peptide

<400>  25

Thr Glu Arg Glu Arg Leu Leu 
1               5           


<210>  26
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  signal peptide

<400>  26

Ser Glu Thr Glu Arg Leu Leu 
1               5           


<210>  27
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  signal peptide

<400>  27

Thr Asp Arg Thr Pro Leu Leu 
1               5           


<210>  28
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  signal peptide

<400>  28

Glu Glu Thr Gln Pro Leu Leu 
1               5           


<210>  29
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  signal peptide

<400>  29

Asp Asp Gln Arg Asp Leu Ile 
1               5           


<210>  30
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  signal peptide

<400>  30

Asn Glu Gln Leu Pro Met Leu 
1               5           


<210>  31
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  signal peptide

<400>  31

Gly Tyr Gln Thr Ile 
1               5   


<210>  32
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  signal peptide

<400>  32

Gly Tyr Glu Gln Phe 
1               5   


<210>  33
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  signal peptide

<400>  33

Gly Tyr Gln Thr Leu 
1               5   


<210>  34
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  signal peptide

<400>  34

Gly Tyr Gln Ser Val 
1               5   


<210>  35
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  signal peptide

<400>  35

Gly Tyr Glu Val Met 
1               5   


<210>  36
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  signal peptide

<400>  36

Ala Tyr Gln Ala Leu 
1               5   


<210>  37
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  signal peptide

<400>  37

Asn Tyr His Thr Leu 
1               5   


<210>  38
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  signal peptide

<400>  38

Gly Tyr Gln Arg Ile 
1               5   


<210>  39
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  signal peptide

<400>  39

Gly Tyr Asp Gln Leu 
1               5   


<210>  40
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  signal peptide

<400>  40

Gly Tyr Lys Glu Ile 
1               5   


<210>  41
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  signal peptide

<400>  41

Gly Tyr Arg His Val 
1               5   


<210>  42
<211>  2300
<212>  DNA
<213>  Homo sapiens

<400>  42
agagtgcacc cgaatccacg ggctcggagg cagcagccat ctctcggcca tagggcaggc       60

cagctggcgc cgggggctat tttgggcggc gggcaatgat ggtgaccgca aggcgacctt      120

gtaaggcatt tcccccctga ctcccttccc cgagcctctg cccgggggtc ctagcgccgc      180

tttctcagcc atcccgccta caacttagcc gtccacaaca ggatcatctg atcgcgtgcg      240

cccgggctac gatctgcgag gcccgcggac cttgacccgg cattgaccgc caccgccccc      300

caggtccgta gggaccaaag aaggggcggg aggaagactg tcacgtggcg ccggagttca      360

cgtgactcgt acacatgact tccagtcccc gggcgcctcc tggagagcaa ggacgcgggg      420

gagcagaggt gagctggcac cggaggctgg aggggatccc cgagcccggg atcgatgatc      480

cgagccgcgc cgccgccgct gttcctgctg ctgctgctgc tgctgctgct agtgtcctgg      540

gcgtcccgag gcgaggcagc ccccgaccag gacgagatcc agcgcctccc cgggctggcc      600

aagcagccgt ctttccgcca gtactccggc tacctcaaag gctccggctc caagcacctc      660

cactactggt ttgtggagtc ccagaaggat cccgagaaca gccctgtggt gctttggctc      720

aatgggggtc ccggctgcag ctcactagat gggctcctca cagagcatgg ccccttcctg      780

gtccagccag atggtgtcac cctggagtac aacccctatt cttggaatct gattgccaat      840

gtgttatacc tggagtcccc agctggggtg ggcttctcct actccgatga caagttttat      900

gcaactaatg acactgaggt cgcccagagc aattttgagg cccttcaaga tttcttccgc      960

ctctttccgg agtacaagaa caacaaactt ttcctgaccg gggagagcta tgctggcatc     1020

tacatcccca ccctggccgt gctggtcatg caggatccca gcatgaacct tcaggggctg     1080

gctgtgggca atggactctc ctcctatgag cagaatgaca actccctggt ctactttgcc     1140

tactaccatg gccttctggg gaacaggctt tggtcttctc tccagaccca ctgctgctct     1200

caaaacaagt gtaacttcta tgacaacaaa gacctggaat gcgtgaccaa tcttcaggaa     1260

gtggcccgca tcgtgggcaa ctctggcctc aacatctaca atctctatgc cccgtgtgct     1320

ggaggggtgc ccagccattt taggtatgag aaggacactg ttgtggtcca ggatttgggc     1380

aacatcttca ctcgcctgcc actcaagcgg atgtggcatc aggcactgct gcgctcaggg     1440

gataaagtgc gcatggaccc cccctgcacc aacacaacag ctgcttccac ctacctcaac     1500

aacccgtacg tgcggaaggc cctcaacatc ccggagcagc tgccacaatg ggacatgtgc     1560

aactttctgg taaacttaca gtaccgccgt ctctaccgaa gcatgaactc ccagtatctg     1620

aagctgctta gctcacagaa ataccagatc ctattatata atggagatgt agacatggcc     1680

tgcaatttca tgggggatga gtggtttgtg gattccctca accagaagat ggaggtgcag     1740

cgccggccct ggttagtgaa gtacggggac agcggggagc agattgccgg cttcgtgaag     1800

gagttctccc acatcgcctt tctcacgatc aagggcgccg gccacatggt tcccaccgac     1860

aagcccctcg ctgccttcac catgttctcc cgcttcctga acaagcagcc atactgatga     1920

ccacagcaac cagctccacg gcctgatgca gcccctccca gcctctcccg ctaggagagt     1980

cctcttctaa gcaaagtgcc cctgcaggcc gggttctgcc gccaggactg cccccttccc     2040

agagccctgt acatcccaga ctgggcccag ggtctcccat agacagcctg ggggcaagtt     2100

agcactttat tcccgcagca gttcctgaat ggggtggcct ggccccttct ctgcttaaag     2160

aatgcccttt atgatgcact gattccatcc caggaaccca acagagctca ggacagccca     2220

cagggaggtg gtggacggac tgtaattgat agattgatta tggaattaaa ttgggtacag     2280

cttcaaaaaa aaaaaaaaaa                                                 2300


<210>  43
<211>  480
<212>  PRT
<213>  Homo sapiens

<400>  43

Met Ile Arg Ala Ala Pro Pro Pro Leu Phe Leu Leu Leu Leu Leu Leu 
1               5                   10                  15      


Leu Leu Leu Val Ser Trp Ala Ser Arg Gly Glu Ala Ala Pro Asp Gln 
            20                  25                  30          


Asp Glu Ile Gln Arg Leu Pro Gly Leu Ala Lys Gln Pro Ser Phe Arg 
        35                  40                  45              


Gln Tyr Ser Gly Tyr Leu Lys Gly Ser Gly Ser Lys His Leu His Tyr 
    50                  55                  60                  


Trp Phe Val Glu Ser Gln Lys Asp Pro Glu Asn Ser Pro Val Val Leu 
65                  70                  75                  80  


Trp Leu Asn Gly Gly Pro Gly Cys Ser Ser Leu Asp Gly Leu Leu Thr 
                85                  90                  95      


Glu His Gly Pro Phe Leu Val Gln Pro Asp Gly Val Thr Leu Glu Tyr 
            100                 105                 110         


Asn Pro Tyr Ser Trp Asn Leu Ile Ala Asn Val Leu Tyr Leu Glu Ser 
        115                 120                 125             


Pro Ala Gly Val Gly Phe Ser Tyr Ser Asp Asp Lys Phe Tyr Ala Thr 
    130                 135                 140                 


Asn Asp Thr Glu Val Ala Gln Ser Asn Phe Glu Ala Leu Gln Asp Phe 
145                 150                 155                 160 


Phe Arg Leu Phe Pro Glu Tyr Lys Asn Asn Lys Leu Phe Leu Thr Gly 
                165                 170                 175     


Glu Ser Tyr Ala Gly Ile Tyr Ile Pro Thr Leu Ala Val Leu Val Met 
            180                 185                 190         


Gln Asp Pro Ser Met Asn Leu Gln Gly Leu Ala Val Gly Asn Gly Leu 
        195                 200                 205             


Ser Ser Tyr Glu Gln Asn Asp Asn Ser Leu Val Tyr Phe Ala Tyr Tyr 
    210                 215                 220                 


His Gly Leu Leu Gly Asn Arg Leu Trp Ser Ser Leu Gln Thr His Cys 
225                 230                 235                 240 


Cys Ser Gln Asn Lys Cys Asn Phe Tyr Asp Asn Lys Asp Leu Glu Cys 
                245                 250                 255     


Val Thr Asn Leu Gln Glu Val Ala Arg Ile Val Gly Asn Ser Gly Leu 
            260                 265                 270         


Asn Ile Tyr Asn Leu Tyr Ala Pro Cys Ala Gly Gly Val Pro Ser His 
        275                 280                 285             


Phe Arg Tyr Glu Lys Asp Thr Val Val Val Gln Asp Leu Gly Asn Ile 
    290                 295                 300                 


Phe Thr Arg Leu Pro Leu Lys Arg Met Trp His Gln Ala Leu Leu Arg 
305                 310                 315                 320 


Ser Gly Asp Lys Val Arg Met Asp Pro Pro Cys Thr Asn Thr Thr Ala 
                325                 330                 335     


Ala Ser Thr Tyr Leu Asn Asn Pro Tyr Val Arg Lys Ala Leu Asn Ile 
            340                 345                 350         


Pro Glu Gln Leu Pro Gln Trp Asp Met Cys Asn Phe Leu Val Asn Leu 
        355                 360                 365             


Gln Tyr Arg Arg Leu Tyr Arg Ser Met Asn Ser Gln Tyr Leu Lys Leu 
    370                 375                 380                 


Leu Ser Ser Gln Lys Tyr Gln Ile Leu Leu Tyr Asn Gly Asp Val Asp 
385                 390                 395                 400 


Met Ala Cys Asn Phe Met Gly Asp Glu Trp Phe Val Asp Ser Leu Asn 
                405                 410                 415     


Gln Lys Met Glu Val Gln Arg Arg Pro Trp Leu Val Lys Tyr Gly Asp 
            420                 425                 430         


Ser Gly Glu Gln Ile Ala Gly Phe Val Lys Glu Phe Ser His Ile Ala 
        435                 440                 445             


Phe Leu Thr Ile Lys Gly Ala Gly His Met Val Pro Thr Asp Lys Pro 
    450                 455                 460                 


Leu Ala Ala Phe Thr Met Phe Ser Arg Phe Leu Asn Lys Gln Pro Tyr 
465                 470                 475                 480 


<210>  44
<211>  2208
<212>  DNA
<213>  Homo sapiens

<400>  44
agagtgcacc cgaatccacg ggctcggagg cagcagccat ctctcggcca tagggcaggc       60

cagctggcgc cgggggctat tttgggcggc gggcaatgat ggtgaccgca aggcgacctt      120

gtaaggcatt tcccccctga ctcccttccc cgagcctctg cccgggggtc ctagcgccgc      180

tttctcagcc atcccgccta caacttagcc gtccacaaca ggatcatctg atcgcgtgcg      240

cccgggctac gatctgcgag gcccgcggac cttgacccgg cattgaccgc caccgccccc      300

caggtccgta gggaccaaag aaggggcggg aggaagactg tcacgtggcg ccggagttca      360

cgtgactcgt acacatgact tccagtcccc gggcgcctcc tggagagcaa ggacgcgggg      420

gagcagagat gatccgagcc gcgccgccgc cgctgttcct gctgctgctg ctgctgctgc      480

tgctagtgtc ctgggcgtcc cgaggcgagg cagcccccga ccaggacgag atccagcgcc      540

tccccgggct ggccaagcag ccgtctttcc gccagtactc cggctacctc aaaggctccg      600

gctccaagca cctccactac tggtttgtgg agtcccagaa ggatcccgag aacagccctg      660

tggtgctttg gctcaatggg ggtcccggct gcagctcact agatgggctc ctcacagagc      720

atggcccctt cctgattgcc aatgtgttat acctggagtc cccagctggg gtgggcttct      780

cctactccga tgacaagttt tatgcaacta atgacactga ggtcgcccag agcaattttg      840

aggcccttca agatttcttc cgcctctttc cggagtacaa gaacaacaaa cttttcctga      900

ccggggagag ctatgctggc atctacatcc ccaccctggc cgtgctggtc atgcaggatc      960

ccagcatgaa ccttcagggg ctggctgtgg gcaatggact ctcctcctat gagcagaatg     1020

acaactccct ggtctacttt gcctactacc atggccttct ggggaacagg ctttggtctt     1080

ctctccagac ccactgctgc tctcaaaaca agtgtaactt ctatgacaac aaagacctgg     1140

aatgcgtgac caatcttcag gaagtggccc gcatcgtggg caactctggc ctcaacatct     1200

acaatctcta tgccccgtgt gctggagggg tgcccagcca ttttaggtat gagaaggaca     1260

ctgttgtggt ccaggatttg ggcaacatct tcactcgcct gccactcaag cggatgtggc     1320

atcaggcact gctgcgctca ggggataaag tgcgcatgga ccccccctgc accaacacaa     1380

cagctgcttc cacctacctc aacaacccgt acgtgcggaa ggccctcaac atcccggagc     1440

agctgccaca atgggacatg tgcaactttc tggtaaactt acagtaccgc cgtctctacc     1500

gaagcatgaa ctcccagtat ctgaagctgc ttagctcaca gaaataccag atcctattat     1560

ataatggaga tgtagacatg gcctgcaatt tcatggggga tgagtggttt gtggattccc     1620

tcaaccagaa gatggaggtg cagcgccggc cctggttagt gaagtacggg gacagcgggg     1680

agcagattgc cggcttcgtg aaggagttct cccacatcgc ctttctcacg atcaagggcg     1740

ccggccacat ggttcccacc gacaagcccc tcgctgcctt caccatgttc tcccgcttcc     1800

tgaacaagca gccatactga tgaccacagc aaccagctcc acggcctgat gcagcccctc     1860

ccagcctctc ccgctaggag agtcctcttc taagcaaagt gcccctgcag gccgggttct     1920

gccgccagga ctgccccctt cccagagccc tgtacatccc agactgggcc cagggtctcc     1980

catagacagc ctgggggcaa gttagcactt tattcccgca gcagttcctg aatggggtgg     2040

cctggcccct tctctgctta aagaatgccc tttatgatgc actgattcca tcccaggaac     2100

ccaacagagc tcaggacagc ccacagggag gtggtggacg gactgtaatt gatagattga     2160

ttatggaatt aaattgggta cagcttcaaa aaaaaaaaaa aaaaaaaa                  2208


<210>  45
<211>  481
<212>  PRT
<213>  Homo sapiens

<400>  45

Met Thr Ser Ser Pro Arg Ala Pro Pro Gly Glu Gln Gly Arg Gly Gly 
1               5                   10                  15      


Ala Glu Met Ile Arg Ala Ala Pro Pro Pro Leu Phe Leu Leu Leu Leu 
            20                  25                  30          


Leu Leu Leu Leu Leu Val Ser Trp Ala Ser Arg Gly Glu Ala Ala Pro 
        35                  40                  45              


Asp Gln Asp Glu Ile Gln Arg Leu Pro Gly Leu Ala Lys Gln Pro Ser 
    50                  55                  60                  


Phe Arg Gln Tyr Ser Gly Tyr Leu Lys Gly Ser Gly Ser Lys His Leu 
65                  70                  75                  80  


His Tyr Trp Phe Val Glu Ser Gln Lys Asp Pro Glu Asn Ser Pro Val 
                85                  90                  95      


Val Leu Trp Leu Asn Gly Gly Pro Gly Cys Ser Ser Leu Asp Gly Leu 
            100                 105                 110         


Leu Thr Glu His Gly Pro Phe Leu Ile Ala Asn Val Leu Tyr Leu Glu 
        115                 120                 125             


Ser Pro Ala Gly Val Gly Phe Ser Tyr Ser Asp Asp Lys Phe Tyr Ala 
    130                 135                 140                 


Thr Asn Asp Thr Glu Val Ala Gln Ser Asn Phe Glu Ala Leu Gln Asp 
145                 150                 155                 160 


Phe Phe Arg Leu Phe Pro Glu Tyr Lys Asn Asn Lys Leu Phe Leu Thr 
                165                 170                 175     


Gly Glu Ser Tyr Ala Gly Ile Tyr Ile Pro Thr Leu Ala Val Leu Val 
            180                 185                 190         


Met Gln Asp Pro Ser Met Asn Leu Gln Gly Leu Ala Val Gly Asn Gly 
        195                 200                 205             


Leu Ser Ser Tyr Glu Gln Asn Asp Asn Ser Leu Val Tyr Phe Ala Tyr 
    210                 215                 220                 


Tyr His Gly Leu Leu Gly Asn Arg Leu Trp Ser Ser Leu Gln Thr His 
225                 230                 235                 240 


Cys Cys Ser Gln Asn Lys Cys Asn Phe Tyr Asp Asn Lys Asp Leu Glu 
                245                 250                 255     


Cys Val Thr Asn Leu Gln Glu Val Ala Arg Ile Val Gly Asn Ser Gly 
            260                 265                 270         


Leu Asn Ile Tyr Asn Leu Tyr Ala Pro Cys Ala Gly Gly Val Pro Ser 
        275                 280                 285             


His Phe Arg Tyr Glu Lys Asp Thr Val Val Val Gln Asp Leu Gly Asn 
    290                 295                 300                 


Ile Phe Thr Arg Leu Pro Leu Lys Arg Met Trp His Gln Ala Leu Leu 
305                 310                 315                 320 


Arg Ser Gly Asp Lys Val Arg Met Asp Pro Pro Cys Thr Asn Thr Thr 
                325                 330                 335     


Ala Ala Ser Thr Tyr Leu Asn Asn Pro Tyr Val Arg Lys Ala Leu Asn 
            340                 345                 350         


Ile Pro Glu Gln Leu Pro Gln Trp Asp Met Cys Asn Phe Leu Val Asn 
        355                 360                 365             


Leu Gln Tyr Arg Arg Leu Tyr Arg Ser Met Asn Ser Gln Tyr Leu Lys 
    370                 375                 380                 


Leu Leu Ser Ser Gln Lys Tyr Gln Ile Leu Leu Tyr Asn Gly Asp Val 
385                 390                 395                 400 


Asp Met Ala Cys Asn Phe Met Gly Asp Glu Trp Phe Val Asp Ser Leu 
                405                 410                 415     


Asn Gln Lys Met Glu Val Gln Arg Arg Pro Trp Leu Val Lys Tyr Gly 
            420                 425                 430         


Asp Ser Gly Glu Gln Ile Ala Gly Phe Val Lys Glu Phe Ser His Ile 
        435                 440                 445             


Ala Phe Leu Thr Ile Lys Gly Ala Gly His Met Val Pro Thr Asp Lys 
    450                 455                 460                 


Pro Leu Ala Ala Phe Thr Met Phe Ser Arg Phe Leu Asn Lys Gln Pro 
465                 470                 475                 480 


Tyr 
    


<210>  46
<211>  3945
<212>  DNA
<213>  Homo sapiens

<400>  46
ggggcggggc cgggagggta cttagggccg gggctggccc aggctacggc ggctgcaggg       60

ctccggcaac cgctccggca acgccaaccg ctccgctgcg cgcaggctgg gctgcaggct      120

ctcggctgca gcgctgggct ggtgtgcagt ggtgcgacca cggctcacgg cagcctcagc      180

cacccagatg taagcgatct ggttcccacc tcagcctccc gagtagtgtc ttcaggccta      240

tggagagcag cttgcgtggg ctgggcctgc agtacctggt ttgcatagat gattggcagg      300

tggatctagg atccggcttc caacatgtgg cagctctggg cctccctctg ctgcctgctg      360

gtgttggcca atgcccggag caggccctct ttccatcccc tgtcggatga gctggtcaac      420

tatgtcaaca aacggaatac cacgtggcag gccgggcaca acttctacaa cgtggacatg      480

agctacttga agaggctatg tggtaccttc ctgggtgggc ccaagccacc ccagagagtt      540

atgtttaccg aggacctgaa gctgcctgca agcttcgatg cacgggaaca atggccacag      600

tgtcccacca tcaaagagat cagagaccag ggctcctgtg gctcctgctg ggccttcggg      660

gctgtggaag ccatctctga ccggatctgc atccacacca atgcgcacgt cagcgtggag      720

gtgtcggcgg aggacctgct cacatgctgt ggcagcatgt gtggggacgg ctgtaatggt      780

ggctatcctg ctgaagcttg gaacttctgg acaagaaaag gcctggtttc tggtggcctc      840

tatgaatccc atgtagggtg cagaccgtac tccatccctc cctgtgagca ccacgtcaac      900

ggctcccggc ccccatgcac gggggaggga gataccccca agtgtagcaa gatctgtgag      960

cctggctaca gcccgaccta caaacaggac aagcactacg gatacaattc ctacagcgtc     1020

tccaatagcg agaaggacat catggccgag atctacaaaa acggccccgt ggagggagct     1080

ttctctgtgt attcggactt cctgctctac aagtcaggag tgtaccaaca cgtcaccgga     1140

gagatgatgg gtggccatgc catccgcatc ctgggctggg gagtggagaa tggcacaccc     1200

tactggctgg ttgccaactc ctggaacact gactggggtg acaatggctt ctttaaaata     1260

ctcagaggac aggatcactg tggaatcgaa tcagaagtgg tggctggaat tccacgcacc     1320

gatcagtact gggaaaagat ctaatctgcc gtgggcctgt cgtgccagtc ctgggggcga     1380

gatcggggta gaaatgcatt ttattcttta agttcacgta agatacaagt ttcagacagg     1440

gtctgaagga ctggattggc caaacatcag acctgtcttc caaggagacc aagtcctggc     1500

tacatcccag cctgtggtta cagtgcagac aggccatgtg agccaccgct gccagcacag     1560

agcgtccttc cccctgtaga ctagtgccgt agggagtacc tgctgcccca gctgactgtg     1620

gccccctccg tgatccatcc atctccaggg agcaagacag agacgcagga atggaaagcg     1680

gagttcctaa caggatgaaa gttcccccat cagttccccc agtacctcca agcaagtagc     1740

tttccacatt tgtcacagaa atcagaggag agacggtgtt gggagccctt tggagaacgc     1800

cagtctccca ggccccctgc atctatcgag tttgcaatgt cacaacctct ctgatcttgt     1860

gctcagcatg attctttaat agaagtttta ttttttcgtg cactctgcta atcatgtggg     1920

tgagccagtg gaacagcggg agacctgtgc tagttttaca gattgcctcc ttatgacgcg     1980

gctcaaaagg aaaccaagtg gtcaggagtt gtttctgacc cactgatctc tactaccaca     2040

aggaaaatag tttaggagaa accagctttt actgtttttg aaaaattaca gcttcaccct     2100

gtcaagttaa caaggaatgc ctgtgccaat aaaagttttc tccaacttga agtctactct     2160

gatgggatct cagatccttt gtcactgcct atagacttgt agctgctgtc tctctttgtc     2220

cctgcagaga atcacgtcct ggaactgcat gttcttgcga ctcttgggac ttcatcttaa     2280

cttctcgctg ccccagccat gttttcaacc atggcatccc tcccccaatt agttccctgt     2340

catcctcgtc aaccttctct gtaagtgcct ggtaagcttg cccttgctta agaactcaaa     2400

acatagctgt gctctatttt tttgttgttg ttgtgactga cagagtgaga ttccgtctcc     2460

caggctggag tgcagtggcg ccttctcagc tcactgcaac ctgcagcctc ctagattcaa     2520

gcgattctcc tgcttcagcc ttccgagtag ctgggatgac aggcactcac caatatgcct     2580

gggtaatttt tgtattttta agtacataca ggatttcacc atgttggcca ggctagtttc     2640

aaactcccgg cctcaggtgg tctgcctgcc tcagcctccc aaagtgttgg gattacaggc     2700

gtgagccact gggccctgcc tgtatttttt atcagccaca aatccagcaa caagctgagg     2760

attcagctca taaaacaggc ttggtgtctt ggtgatctca cataaccaag atgctacccc     2820

gtggggaacc acatccccct ggatgccctc cagccttggt ttgggctgga gtcagggcct     2880

gtatacagta ttttgaattt gtatgccact ggtttgcatt gctggtcagg aactctagtg     2940

ctttgcatag ccctggttta gaaacatgtt atagcagttc ttggtataga gcaaactaga     3000

agaaccagca atcattccac tgtcctgcca aggtacacct cagtactccc cttcccaact     3060

gaagtggtat gaggctagct ctttccaaaa gcattcaagt ttggcttctg atgtgactca     3120

gaatttagga accagatgct agatcaaata agctctgaaa atctgaggaa cattgtagga     3180

aaggtttgtt aagcatctct taagtgccat gatgagcata acagccggcc gtcgtggctc     3240

acgcctgtaa tcccagcact ttgggaggcc aaggtgggag gatgacaagg tcaggagttc     3300

aagaccagcc tggccaacat gctgaaacct cacctctact aaaaatacaa aaattagctg     3360

ggcatggtgg cacatgcctg taatcccagc tacttgggag gctgaggcag gagaatcgct     3420

tgaacccggg aggcggaggt tgcagtgagc caagacagtg ccagtgcact ccagcctcgg     3480

tgacagcgca aggctccgtc tcaataatta aaaaaaaaaa aaaaaaaaaa aaggccgggc     3540

gcagtggctc aagcctgtaa tcccagcact ttgggaggct gaggcgggca gatcacctga     3600

ggtcaggagt tttgagatca gccttggcaa cacggtgaaa ccccatctct actaaaaata     3660

caaaattagc caagcatgct ggcacatgcc tgtaatccca gctactcggg aggctgaggt     3720

acgagaatcg cttgaacctg ggaggcagag gatgcagtga gccgagatca cgccattgca     3780

ctccagcctg ggggacaaga gtgaatctgt gtctcaccaa aaaaaaaaag aaaaagaaag     3840

atgcttaaca aaggttacca taagccacaa attcataacc acttatcctt ccagtttcaa     3900

gtagaatata ttcataacct caataaagtt ctccctgctc ccaaa                     3945


<210>  47
<211>  339
<212>  PRT
<213>  Homo sapiens

<400>  47

Met Trp Gln Leu Trp Ala Ser Leu Cys Cys Leu Leu Val Leu Ala Asn 
1               5                   10                  15      


Ala Arg Ser Arg Pro Ser Phe His Pro Leu Ser Asp Glu Leu Val Asn 
            20                  25                  30          


Tyr Val Asn Lys Arg Asn Thr Thr Trp Gln Ala Gly His Asn Phe Tyr 
        35                  40                  45              


Asn Val Asp Met Ser Tyr Leu Lys Arg Leu Cys Gly Thr Phe Leu Gly 
    50                  55                  60                  


Gly Pro Lys Pro Pro Gln Arg Val Met Phe Thr Glu Asp Leu Lys Leu 
65                  70                  75                  80  


Pro Ala Ser Phe Asp Ala Arg Glu Gln Trp Pro Gln Cys Pro Thr Ile 
                85                  90                  95      


Lys Glu Ile Arg Asp Gln Gly Ser Cys Gly Ser Cys Trp Ala Phe Gly 
            100                 105                 110         


Ala Val Glu Ala Ile Ser Asp Arg Ile Cys Ile His Thr Asn Ala His 
        115                 120                 125             


Val Ser Val Glu Val Ser Ala Glu Asp Leu Leu Thr Cys Cys Gly Ser 
    130                 135                 140                 


Met Cys Gly Asp Gly Cys Asn Gly Gly Tyr Pro Ala Glu Ala Trp Asn 
145                 150                 155                 160 


Phe Trp Thr Arg Lys Gly Leu Val Ser Gly Gly Leu Tyr Glu Ser His 
                165                 170                 175     


Val Gly Cys Arg Pro Tyr Ser Ile Pro Pro Cys Glu His His Val Asn 
            180                 185                 190         


Gly Ser Arg Pro Pro Cys Thr Gly Glu Gly Asp Thr Pro Lys Cys Ser 
        195                 200                 205             


Lys Ile Cys Glu Pro Gly Tyr Ser Pro Thr Tyr Lys Gln Asp Lys His 
    210                 215                 220                 


Tyr Gly Tyr Asn Ser Tyr Ser Val Ser Asn Ser Glu Lys Asp Ile Met 
225                 230                 235                 240 


Ala Glu Ile Tyr Lys Asn Gly Pro Val Glu Gly Ala Phe Ser Val Tyr 
                245                 250                 255     


Ser Asp Phe Leu Leu Tyr Lys Ser Gly Val Tyr Gln His Val Thr Gly 
            260                 265                 270         


Glu Met Met Gly Gly His Ala Ile Arg Ile Leu Gly Trp Gly Val Glu 
        275                 280                 285             


Asn Gly Thr Pro Tyr Trp Leu Val Ala Asn Ser Trp Asn Thr Asp Trp 
    290                 295                 300                 


Gly Asp Asn Gly Phe Phe Lys Ile Leu Arg Gly Gln Asp His Cys Gly 
305                 310                 315                 320 


Ile Glu Ser Glu Val Val Ala Gly Ile Pro Arg Thr Asp Gln Tyr Trp 
                325                 330                 335     


Glu Lys Ile 
            


<210>  48
<211>  3902
<212>  DNA
<213>  Homo sapiens

<400>  48
ggggcggggc cgggagggta cttagggccg gggctggccc aggctacggc ggctgcaggg       60

ctccggcaac cgctccggca acgccaaccg ctccgctgcg cgcaggctgg gctgcaggct      120

ctcggctgca gcgctgggtg tcttcaggcc tatggagagc agcttgcgtg ggctgggcct      180

gcagtacctg gtttgcatag atgattggca ggtgggcagc acggggaagg acctgtgagt      240

ggccaacctg gttcaggtgg atctaggatc cggcttccaa catgtggcag ctctgggcct      300

ccctctgctg cctgctggtg ttggccaatg cccggagcag gccctctttc catcccctgt      360

cggatgagct ggtcaactat gtcaacaaac ggaataccac gtggcaggcc gggcacaact      420

tctacaacgt ggacatgagc tacttgaaga ggctatgtgg taccttcctg ggtgggccca      480

agccacccca gagagttatg tttaccgagg acctgaagct gcctgcaagc ttcgatgcac      540

gggaacaatg gccacagtgt cccaccatca aagagatcag agaccagggc tcctgtggct      600

cctgctgggc cttcggggct gtggaagcca tctctgaccg gatctgcatc cacaccaatg      660

cgcacgtcag cgtggaggtg tcggcggagg acctgctcac atgctgtggc agcatgtgtg      720

gggacggctg taatggtggc tatcctgctg aagcttggaa cttctggaca agaaaaggcc      780

tggtttctgg tggcctctat gaatcccatg tagggtgcag accgtactcc atccctccct      840

gtgagcacca cgtcaacggc tcccggcccc catgcacggg ggagggagat acccccaagt      900

gtagcaagat ctgtgagcct ggctacagcc cgacctacaa acaggacaag cactacggat      960

acaattccta cagcgtctcc aatagcgaga aggacatcat ggccgagatc tacaaaaacg     1020

gccccgtgga gggagctttc tctgtgtatt cggacttcct gctctacaag tcaggagtgt     1080

accaacacgt caccggagag atgatgggtg gccatgccat ccgcatcctg ggctggggag     1140

tggagaatgg cacaccctac tggctggttg ccaactcctg gaacactgac tggggtgaca     1200

atggcttctt taaaatactc agaggacagg atcactgtgg aatcgaatca gaagtggtgg     1260

ctggaattcc acgcaccgat cagtactggg aaaagatcta atctgccgtg ggcctgtcgt     1320

gccagtcctg ggggcgagat cggggtagaa atgcatttta ttctttaagt tcacgtaaga     1380

tacaagtttc agacagggtc tgaaggactg gattggccaa acatcagacc tgtcttccaa     1440

ggagaccaag tcctggctac atcccagcct gtggttacag tgcagacagg ccatgtgagc     1500

caccgctgcc agcacagagc gtccttcccc ctgtagacta gtgccgtagg gagtacctgc     1560

tgccccagct gactgtggcc ccctccgtga tccatccatc tccagggagc aagacagaga     1620

cgcaggaatg gaaagcggag ttcctaacag gatgaaagtt cccccatcag ttcccccagt     1680

acctccaagc aagtagcttt ccacatttgt cacagaaatc agaggagaga cggtgttggg     1740

agccctttgg agaacgccag tctcccaggc cccctgcatc tatcgagttt gcaatgtcac     1800

aacctctctg atcttgtgct cagcatgatt ctttaataga agttttattt tttcgtgcac     1860

tctgctaatc atgtgggtga gccagtggaa cagcgggaga cctgtgctag ttttacagat     1920

tgcctcctta tgacgcggct caaaaggaaa ccaagtggtc aggagttgtt tctgacccac     1980

tgatctctac taccacaagg aaaatagttt aggagaaacc agcttttact gtttttgaaa     2040

aattacagct tcaccctgtc aagttaacaa ggaatgcctg tgccaataaa agttttctcc     2100

aacttgaagt ctactctgat gggatctcag atcctttgtc actgcctata gacttgtagc     2160

tgctgtctct ctttgtccct gcagagaatc acgtcctgga actgcatgtt cttgcgactc     2220

ttgggacttc atcttaactt ctcgctgccc cagccatgtt ttcaaccatg gcatccctcc     2280

cccaattagt tccctgtcat cctcgtcaac cttctctgta agtgcctggt aagcttgccc     2340

ttgcttaaga actcaaaaca tagctgtgct ctattttttt gttgttgttg tgactgacag     2400

agtgagattc cgtctcccag gctggagtgc agtggcgcct tctcagctca ctgcaacctg     2460

cagcctccta gattcaagcg attctcctgc ttcagccttc cgagtagctg ggatgacagg     2520

cactcaccaa tatgcctggg taatttttgt atttttaagt acatacagga tttcaccatg     2580

ttggccaggc tagtttcaaa ctcccggcct caggtggtct gcctgcctca gcctcccaaa     2640

gtgttgggat tacaggcgtg agccactggg ccctgcctgt attttttatc agccacaaat     2700

ccagcaacaa gctgaggatt cagctcataa aacaggcttg gtgtcttggt gatctcacat     2760

aaccaagatg ctaccccgtg gggaaccaca tccccctgga tgccctccag ccttggtttg     2820

ggctggagtc agggcctgta tacagtattt tgaatttgta tgccactggt ttgcattgct     2880

ggtcaggaac tctagtgctt tgcatagccc tggtttagaa acatgttata gcagttcttg     2940

gtatagagca aactagaaga accagcaatc attccactgt cctgccaagg tacacctcag     3000

tactcccctt cccaactgaa gtggtatgag gctagctctt tccaaaagca ttcaagtttg     3060

gcttctgatg tgactcagaa tttaggaacc agatgctaga tcaaataagc tctgaaaatc     3120

tgaggaacat tgtaggaaag gtttgttaag catctcttaa gtgccatgat gagcataaca     3180

gccggccgtc gtggctcacg cctgtaatcc cagcactttg ggaggccaag gtgggaggat     3240

gacaaggtca ggagttcaag accagcctgg ccaacatgct gaaacctcac ctctactaaa     3300

aatacaaaaa ttagctgggc atggtggcac atgcctgtaa tcccagctac ttgggaggct     3360

gaggcaggag aatcgcttga acccgggagg cggaggttgc agtgagccaa gacagtgcca     3420

gtgcactcca gcctcggtga cagcgcaagg ctccgtctca ataattaaaa aaaaaaaaaa     3480

aaaaaaaaag gccgggcgca gtggctcaag cctgtaatcc cagcactttg ggaggctgag     3540

gcgggcagat cacctgaggt caggagtttt gagatcagcc ttggcaacac ggtgaaaccc     3600

catctctact aaaaatacaa aattagccaa gcatgctggc acatgcctgt aatcccagct     3660

actcgggagg ctgaggtacg agaatcgctt gaacctggga ggcagaggat gcagtgagcc     3720

gagatcacgc cattgcactc cagcctgggg gacaagagtg aatctgtgtc tcaccaaaaa     3780

aaaaaagaaa aagaaagatg cttaacaaag gttaccataa gccacaaatt cataaccact     3840

tatccttcca gtttcaagta gaatatattc ataacctcaa taaagttctc cctgctccca     3900

aa                                                                    3902


<210>  49
<211>  339
<212>  PRT
<213>  Homo sapiens

<400>  49

Met Trp Gln Leu Trp Ala Ser Leu Cys Cys Leu Leu Val Leu Ala Asn 
1               5                   10                  15      


Ala Arg Ser Arg Pro Ser Phe His Pro Leu Ser Asp Glu Leu Val Asn 
            20                  25                  30          


Tyr Val Asn Lys Arg Asn Thr Thr Trp Gln Ala Gly His Asn Phe Tyr 
        35                  40                  45              


Asn Val Asp Met Ser Tyr Leu Lys Arg Leu Cys Gly Thr Phe Leu Gly 
    50                  55                  60                  


Gly Pro Lys Pro Pro Gln Arg Val Met Phe Thr Glu Asp Leu Lys Leu 
65                  70                  75                  80  


Pro Ala Ser Phe Asp Ala Arg Glu Gln Trp Pro Gln Cys Pro Thr Ile 
                85                  90                  95      


Lys Glu Ile Arg Asp Gln Gly Ser Cys Gly Ser Cys Trp Ala Phe Gly 
            100                 105                 110         


Ala Val Glu Ala Ile Ser Asp Arg Ile Cys Ile His Thr Asn Ala His 
        115                 120                 125             


Val Ser Val Glu Val Ser Ala Glu Asp Leu Leu Thr Cys Cys Gly Ser 
    130                 135                 140                 


Met Cys Gly Asp Gly Cys Asn Gly Gly Tyr Pro Ala Glu Ala Trp Asn 
145                 150                 155                 160 


Phe Trp Thr Arg Lys Gly Leu Val Ser Gly Gly Leu Tyr Glu Ser His 
                165                 170                 175     


Val Gly Cys Arg Pro Tyr Ser Ile Pro Pro Cys Glu His His Val Asn 
            180                 185                 190         


Gly Ser Arg Pro Pro Cys Thr Gly Glu Gly Asp Thr Pro Lys Cys Ser 
        195                 200                 205             


Lys Ile Cys Glu Pro Gly Tyr Ser Pro Thr Tyr Lys Gln Asp Lys His 
    210                 215                 220                 


Tyr Gly Tyr Asn Ser Tyr Ser Val Ser Asn Ser Glu Lys Asp Ile Met 
225                 230                 235                 240 


Ala Glu Ile Tyr Lys Asn Gly Pro Val Glu Gly Ala Phe Ser Val Tyr 
                245                 250                 255     


Ser Asp Phe Leu Leu Tyr Lys Ser Gly Val Tyr Gln His Val Thr Gly 
            260                 265                 270         


Glu Met Met Gly Gly His Ala Ile Arg Ile Leu Gly Trp Gly Val Glu 
        275                 280                 285             


Asn Gly Thr Pro Tyr Trp Leu Val Ala Asn Ser Trp Asn Thr Asp Trp 
    290                 295                 300                 


Gly Asp Asn Gly Phe Phe Lys Ile Leu Arg Gly Gln Asp His Cys Gly 
305                 310                 315                 320 


Ile Glu Ser Glu Val Val Ala Gly Ile Pro Arg Thr Asp Gln Tyr Trp 
                325                 330                 335     


Glu Lys Ile 
            


<210>  50
<211>  3871
<212>  DNA
<213>  Homo sapiens

<400>  50
ggggcggggc cgggagggta cttagggccg gggctggccc aggctacggc ggctgcaggg       60

ctccggcaac cgctccggca acgccaaccg ctccgctgcg cgcaggctgg gctgcaggct      120

ctcggctgca gcgctgggct ggtgtgcagt ggtgcgacca cggctcacgg cagcctcagc      180

cacccagatg taagcgatct ggttcccacc tcagcctccc gagtagtgga tctaggatcc      240

ggcttccaac atgtggcagc tctgggcctc cctctgctgc ctgctggtgt tggccaatgc      300

ccggagcagg ccctctttcc atcccctgtc ggatgagctg gtcaactatg tcaacaaacg      360

gaataccacg tggcaggccg ggcacaactt ctacaacgtg gacatgagct acttgaagag      420

gctatgtggt accttcctgg gtgggcccaa gccaccccag agagttatgt ttaccgagga      480

cctgaagctg cctgcaagct tcgatgcacg ggaacaatgg ccacagtgtc ccaccatcaa      540

agagatcaga gaccagggct cctgtggctc ctgctgggcc ttcggggctg tggaagccat      600

ctctgaccgg atctgcatcc acaccaatgc gcacgtcagc gtggaggtgt cggcggagga      660

cctgctcaca tgctgtggca gcatgtgtgg ggacggctgt aatggtggct atcctgctga      720

agcttggaac ttctggacaa gaaaaggcct ggtttctggt ggcctctatg aatcccatgt      780

agggtgcaga ccgtactcca tccctccctg tgagcaccac gtcaacggct cccggccccc      840

atgcacgggg gagggagata cccccaagtg tagcaagatc tgtgagcctg gctacagccc      900

gacctacaaa caggacaagc actacggata caattcctac agcgtctcca atagcgagaa      960

ggacatcatg gccgagatct acaaaaacgg ccccgtggag ggagctttct ctgtgtattc     1020

ggacttcctg ctctacaagt caggagtgta ccaacacgtc accggagaga tgatgggtgg     1080

ccatgccatc cgcatcctgg gctggggagt ggagaatggc acaccctact ggctggttgc     1140

caactcctgg aacactgact ggggtgacaa tggcttcttt aaaatactca gaggacagga     1200

tcactgtgga atcgaatcag aagtggtggc tggaattcca cgcaccgatc agtactggga     1260

aaagatctaa tctgccgtgg gcctgtcgtg ccagtcctgg gggcgagatc ggggtagaaa     1320

tgcattttat tctttaagtt cacgtaagat acaagtttca gacagggtct gaaggactgg     1380

attggccaaa catcagacct gtcttccaag gagaccaagt cctggctaca tcccagcctg     1440

tggttacagt gcagacaggc catgtgagcc accgctgcca gcacagagcg tccttccccc     1500

tgtagactag tgccgtaggg agtacctgct gccccagctg actgtggccc cctccgtgat     1560

ccatccatct ccagggagca agacagagac gcaggaatgg aaagcggagt tcctaacagg     1620

atgaaagttc ccccatcagt tcccccagta cctccaagca agtagctttc cacatttgtc     1680

acagaaatca gaggagagac ggtgttggga gccctttgga gaacgccagt ctcccaggcc     1740

ccctgcatct atcgagtttg caatgtcaca acctctctga tcttgtgctc agcatgattc     1800

tttaatagaa gttttatttt ttcgtgcact ctgctaatca tgtgggtgag ccagtggaac     1860

agcgggagac ctgtgctagt tttacagatt gcctccttat gacgcggctc aaaaggaaac     1920

caagtggtca ggagttgttt ctgacccact gatctctact accacaagga aaatagttta     1980

ggagaaacca gcttttactg tttttgaaaa attacagctt caccctgtca agttaacaag     2040

gaatgcctgt gccaataaaa gttttctcca acttgaagtc tactctgatg ggatctcaga     2100

tcctttgtca ctgcctatag acttgtagct gctgtctctc tttgtccctg cagagaatca     2160

cgtcctggaa ctgcatgttc ttgcgactct tgggacttca tcttaacttc tcgctgcccc     2220

agccatgttt tcaaccatgg catccctccc ccaattagtt ccctgtcatc ctcgtcaacc     2280

ttctctgtaa gtgcctggta agcttgccct tgcttaagaa ctcaaaacat agctgtgctc     2340

tatttttttg ttgttgttgt gactgacaga gtgagattcc gtctcccagg ctggagtgca     2400

gtggcgcctt ctcagctcac tgcaacctgc agcctcctag attcaagcga ttctcctgct     2460

tcagccttcc gagtagctgg gatgacaggc actcaccaat atgcctgggt aatttttgta     2520

tttttaagta catacaggat ttcaccatgt tggccaggct agtttcaaac tcccggcctc     2580

aggtggtctg cctgcctcag cctcccaaag tgttgggatt acaggcgtga gccactgggc     2640

cctgcctgta ttttttatca gccacaaatc cagcaacaag ctgaggattc agctcataaa     2700

acaggcttgg tgtcttggtg atctcacata accaagatgc taccccgtgg ggaaccacat     2760

ccccctggat gccctccagc cttggtttgg gctggagtca gggcctgtat acagtatttt     2820

gaatttgtat gccactggtt tgcattgctg gtcaggaact ctagtgcttt gcatagccct     2880

ggtttagaaa catgttatag cagttcttgg tatagagcaa actagaagaa ccagcaatca     2940

ttccactgtc ctgccaaggt acacctcagt actccccttc ccaactgaag tggtatgagg     3000

ctagctcttt ccaaaagcat tcaagtttgg cttctgatgt gactcagaat ttaggaacca     3060

gatgctagat caaataagct ctgaaaatct gaggaacatt gtaggaaagg tttgttaagc     3120

atctcttaag tgccatgatg agcataacag ccggccgtcg tggctcacgc ctgtaatccc     3180

agcactttgg gaggccaagg tgggaggatg acaaggtcag gagttcaaga ccagcctggc     3240

caacatgctg aaacctcacc tctactaaaa atacaaaaat tagctgggca tggtggcaca     3300

tgcctgtaat cccagctact tgggaggctg aggcaggaga atcgcttgaa cccgggaggc     3360

ggaggttgca gtgagccaag acagtgccag tgcactccag cctcggtgac agcgcaaggc     3420

tccgtctcaa taattaaaaa aaaaaaaaaa aaaaaaaagg ccgggcgcag tggctcaagc     3480

ctgtaatccc agcactttgg gaggctgagg cgggcagatc acctgaggtc aggagttttg     3540

agatcagcct tggcaacacg gtgaaacccc atctctacta aaaatacaaa attagccaag     3600

catgctggca catgcctgta atcccagcta ctcgggaggc tgaggtacga gaatcgcttg     3660

aacctgggag gcagaggatg cagtgagccg agatcacgcc attgcactcc agcctggggg     3720

acaagagtga atctgtgtct caccaaaaaa aaaaagaaaa agaaagatgc ttaacaaagg     3780

ttaccataag ccacaaattc ataaccactt atccttccag tttcaagtag aatatattca     3840

taacctcaat aaagttctcc ctgctcccaa a                                    3871


<210>  51
<211>  339
<212>  PRT
<213>  Homo sapiens

<400>  51

Met Trp Gln Leu Trp Ala Ser Leu Cys Cys Leu Leu Val Leu Ala Asn 
1               5                   10                  15      


Ala Arg Ser Arg Pro Ser Phe His Pro Leu Ser Asp Glu Leu Val Asn 
            20                  25                  30          


Tyr Val Asn Lys Arg Asn Thr Thr Trp Gln Ala Gly His Asn Phe Tyr 
        35                  40                  45              


Asn Val Asp Met Ser Tyr Leu Lys Arg Leu Cys Gly Thr Phe Leu Gly 
    50                  55                  60                  


Gly Pro Lys Pro Pro Gln Arg Val Met Phe Thr Glu Asp Leu Lys Leu 
65                  70                  75                  80  


Pro Ala Ser Phe Asp Ala Arg Glu Gln Trp Pro Gln Cys Pro Thr Ile 
                85                  90                  95      


Lys Glu Ile Arg Asp Gln Gly Ser Cys Gly Ser Cys Trp Ala Phe Gly 
            100                 105                 110         


Ala Val Glu Ala Ile Ser Asp Arg Ile Cys Ile His Thr Asn Ala His 
        115                 120                 125             


Val Ser Val Glu Val Ser Ala Glu Asp Leu Leu Thr Cys Cys Gly Ser 
    130                 135                 140                 


Met Cys Gly Asp Gly Cys Asn Gly Gly Tyr Pro Ala Glu Ala Trp Asn 
145                 150                 155                 160 


Phe Trp Thr Arg Lys Gly Leu Val Ser Gly Gly Leu Tyr Glu Ser His 
                165                 170                 175     


Val Gly Cys Arg Pro Tyr Ser Ile Pro Pro Cys Glu His His Val Asn 
            180                 185                 190         


Gly Ser Arg Pro Pro Cys Thr Gly Glu Gly Asp Thr Pro Lys Cys Ser 
        195                 200                 205             


Lys Ile Cys Glu Pro Gly Tyr Ser Pro Thr Tyr Lys Gln Asp Lys His 
    210                 215                 220                 


Tyr Gly Tyr Asn Ser Tyr Ser Val Ser Asn Ser Glu Lys Asp Ile Met 
225                 230                 235                 240 


Ala Glu Ile Tyr Lys Asn Gly Pro Val Glu Gly Ala Phe Ser Val Tyr 
                245                 250                 255     


Ser Asp Phe Leu Leu Tyr Lys Ser Gly Val Tyr Gln His Val Thr Gly 
            260                 265                 270         


Glu Met Met Gly Gly His Ala Ile Arg Ile Leu Gly Trp Gly Val Glu 
        275                 280                 285             


Asn Gly Thr Pro Tyr Trp Leu Val Ala Asn Ser Trp Asn Thr Asp Trp 
    290                 295                 300                 


Gly Asp Asn Gly Phe Phe Lys Ile Leu Arg Gly Gln Asp His Cys Gly 
305                 310                 315                 320 


Ile Glu Ser Glu Val Val Ala Gly Ile Pro Arg Thr Asp Gln Tyr Trp 
                325                 330                 335     


Glu Lys Ile 
            


<210>  52
<211>  3857
<212>  DNA
<213>  Homo sapiens

<400>  52
ggggcggggc cgggagggta cttagggccg gggctggccc aggctacggc ggctgcaggg       60

ctccggcaac cgctccggca acgccaaccg ctccgctgcg cgcaggctgg gctgcaggct      120

ctcggctgca gcgctgggtg tcttcaggcc tatggagagc agcttgcgtg ggctgggcct      180

gcagtacctg gtttgcatag atgattggca ggtggatcta ggatccggct tccaacatgt      240

ggcagctctg ggcctccctc tgctgcctgc tggtgttggc caatgcccgg agcaggccct      300

ctttccatcc cctgtcggat gagctggtca actatgtcaa caaacggaat accacgtggc      360

aggccgggca caacttctac aacgtggaca tgagctactt gaagaggcta tgtggtacct      420

tcctgggtgg gcccaagcca ccccagagag ttatgtttac cgaggacctg aagctgcctg      480

caagcttcga tgcacgggaa caatggccac agtgtcccac catcaaagag atcagagacc      540

agggctcctg tggctcctgc tgggccttcg gggctgtgga agccatctct gaccggatct      600

gcatccacac caatgcgcac gtcagcgtgg aggtgtcggc ggaggacctg ctcacatgct      660

gtggcagcat gtgtggggac ggctgtaatg gtggctatcc tgctgaagct tggaacttct      720

ggacaagaaa aggcctggtt tctggtggcc tctatgaatc ccatgtaggg tgcagaccgt      780

actccatccc tccctgtgag caccacgtca acggctcccg gcccccatgc acgggggagg      840

gagatacccc caagtgtagc aagatctgtg agcctggcta cagcccgacc tacaaacagg      900

acaagcacta cggatacaat tcctacagcg tctccaatag cgagaaggac atcatggccg      960

agatctacaa aaacggcccc gtggagggag ctttctctgt gtattcggac ttcctgctct     1020

acaagtcagg agtgtaccaa cacgtcaccg gagagatgat gggtggccat gccatccgca     1080

tcctgggctg gggagtggag aatggcacac cctactggct ggttgccaac tcctggaaca     1140

ctgactgggg tgacaatggc ttctttaaaa tactcagagg acaggatcac tgtggaatcg     1200

aatcagaagt ggtggctgga attccacgca ccgatcagta ctgggaaaag atctaatctg     1260

ccgtgggcct gtcgtgccag tcctgggggc gagatcgggg tagaaatgca ttttattctt     1320

taagttcacg taagatacaa gtttcagaca gggtctgaag gactggattg gccaaacatc     1380

agacctgtct tccaaggaga ccaagtcctg gctacatccc agcctgtggt tacagtgcag     1440

acaggccatg tgagccaccg ctgccagcac agagcgtcct tccccctgta gactagtgcc     1500

gtagggagta cctgctgccc cagctgactg tggccccctc cgtgatccat ccatctccag     1560

ggagcaagac agagacgcag gaatggaaag cggagttcct aacaggatga aagttccccc     1620

atcagttccc ccagtacctc caagcaagta gctttccaca tttgtcacag aaatcagagg     1680

agagacggtg ttgggagccc tttggagaac gccagtctcc caggccccct gcatctatcg     1740

agtttgcaat gtcacaacct ctctgatctt gtgctcagca tgattcttta atagaagttt     1800

tattttttcg tgcactctgc taatcatgtg ggtgagccag tggaacagcg ggagacctgt     1860

gctagtttta cagattgcct ccttatgacg cggctcaaaa ggaaaccaag tggtcaggag     1920

ttgtttctga cccactgatc tctactacca caaggaaaat agtttaggag aaaccagctt     1980

ttactgtttt tgaaaaatta cagcttcacc ctgtcaagtt aacaaggaat gcctgtgcca     2040

ataaaagttt tctccaactt gaagtctact ctgatgggat ctcagatcct ttgtcactgc     2100

ctatagactt gtagctgctg tctctctttg tccctgcaga gaatcacgtc ctggaactgc     2160

atgttcttgc gactcttggg acttcatctt aacttctcgc tgccccagcc atgttttcaa     2220

ccatggcatc cctcccccaa ttagttccct gtcatcctcg tcaaccttct ctgtaagtgc     2280

ctggtaagct tgcccttgct taagaactca aaacatagct gtgctctatt tttttgttgt     2340

tgttgtgact gacagagtga gattccgtct cccaggctgg agtgcagtgg cgccttctca     2400

gctcactgca acctgcagcc tcctagattc aagcgattct cctgcttcag ccttccgagt     2460

agctgggatg acaggcactc accaatatgc ctgggtaatt tttgtatttt taagtacata     2520

caggatttca ccatgttggc caggctagtt tcaaactccc ggcctcaggt ggtctgcctg     2580

cctcagcctc ccaaagtgtt gggattacag gcgtgagcca ctgggccctg cctgtatttt     2640

ttatcagcca caaatccagc aacaagctga ggattcagct cataaaacag gcttggtgtc     2700

ttggtgatct cacataacca agatgctacc ccgtggggaa ccacatcccc ctggatgccc     2760

tccagccttg gtttgggctg gagtcagggc ctgtatacag tattttgaat ttgtatgcca     2820

ctggtttgca ttgctggtca ggaactctag tgctttgcat agccctggtt tagaaacatg     2880

ttatagcagt tcttggtata gagcaaacta gaagaaccag caatcattcc actgtcctgc     2940

caaggtacac ctcagtactc cccttcccaa ctgaagtggt atgaggctag ctctttccaa     3000

aagcattcaa gtttggcttc tgatgtgact cagaatttag gaaccagatg ctagatcaaa     3060

taagctctga aaatctgagg aacattgtag gaaaggtttg ttaagcatct cttaagtgcc     3120

atgatgagca taacagccgg ccgtcgtggc tcacgcctgt aatcccagca ctttgggagg     3180

ccaaggtggg aggatgacaa ggtcaggagt tcaagaccag cctggccaac atgctgaaac     3240

ctcacctcta ctaaaaatac aaaaattagc tgggcatggt ggcacatgcc tgtaatccca     3300

gctacttggg aggctgaggc aggagaatcg cttgaacccg ggaggcggag gttgcagtga     3360

gccaagacag tgccagtgca ctccagcctc ggtgacagcg caaggctccg tctcaataat     3420

taaaaaaaaa aaaaaaaaaa aaaaggccgg gcgcagtggc tcaagcctgt aatcccagca     3480

ctttgggagg ctgaggcggg cagatcacct gaggtcagga gttttgagat cagccttggc     3540

aacacggtga aaccccatct ctactaaaaa tacaaaatta gccaagcatg ctggcacatg     3600

cctgtaatcc cagctactcg ggaggctgag gtacgagaat cgcttgaacc tgggaggcag     3660

aggatgcagt gagccgagat cacgccattg cactccagcc tgggggacaa gagtgaatct     3720

gtgtctcacc aaaaaaaaaa agaaaaagaa agatgcttaa caaaggttac cataagccac     3780

aaattcataa ccacttatcc ttccagtttc aagtagaata tattcataac ctcaataaag     3840

ttctccctgc tcccaaa                                                    3857


<210>  53
<211>  339
<212>  PRT
<213>  Homo sapiens

<400>  53

Met Trp Gln Leu Trp Ala Ser Leu Cys Cys Leu Leu Val Leu Ala Asn 
1               5                   10                  15      


Ala Arg Ser Arg Pro Ser Phe His Pro Leu Ser Asp Glu Leu Val Asn 
            20                  25                  30          


Tyr Val Asn Lys Arg Asn Thr Thr Trp Gln Ala Gly His Asn Phe Tyr 
        35                  40                  45              


Asn Val Asp Met Ser Tyr Leu Lys Arg Leu Cys Gly Thr Phe Leu Gly 
    50                  55                  60                  


Gly Pro Lys Pro Pro Gln Arg Val Met Phe Thr Glu Asp Leu Lys Leu 
65                  70                  75                  80  


Pro Ala Ser Phe Asp Ala Arg Glu Gln Trp Pro Gln Cys Pro Thr Ile 
                85                  90                  95      


Lys Glu Ile Arg Asp Gln Gly Ser Cys Gly Ser Cys Trp Ala Phe Gly 
            100                 105                 110         


Ala Val Glu Ala Ile Ser Asp Arg Ile Cys Ile His Thr Asn Ala His 
        115                 120                 125             


Val Ser Val Glu Val Ser Ala Glu Asp Leu Leu Thr Cys Cys Gly Ser 
    130                 135                 140                 


Met Cys Gly Asp Gly Cys Asn Gly Gly Tyr Pro Ala Glu Ala Trp Asn 
145                 150                 155                 160 


Phe Trp Thr Arg Lys Gly Leu Val Ser Gly Gly Leu Tyr Glu Ser His 
                165                 170                 175     


Val Gly Cys Arg Pro Tyr Ser Ile Pro Pro Cys Glu His His Val Asn 
            180                 185                 190         


Gly Ser Arg Pro Pro Cys Thr Gly Glu Gly Asp Thr Pro Lys Cys Ser 
        195                 200                 205             


Lys Ile Cys Glu Pro Gly Tyr Ser Pro Thr Tyr Lys Gln Asp Lys His 
    210                 215                 220                 


Tyr Gly Tyr Asn Ser Tyr Ser Val Ser Asn Ser Glu Lys Asp Ile Met 
225                 230                 235                 240 


Ala Glu Ile Tyr Lys Asn Gly Pro Val Glu Gly Ala Phe Ser Val Tyr 
                245                 250                 255     


Ser Asp Phe Leu Leu Tyr Lys Ser Gly Val Tyr Gln His Val Thr Gly 
            260                 265                 270         


Glu Met Met Gly Gly His Ala Ile Arg Ile Leu Gly Trp Gly Val Glu 
        275                 280                 285             


Asn Gly Thr Pro Tyr Trp Leu Val Ala Asn Ser Trp Asn Thr Asp Trp 
    290                 295                 300                 


Gly Asp Asn Gly Phe Phe Lys Ile Leu Arg Gly Gln Asp His Cys Gly 
305                 310                 315                 320 


Ile Glu Ser Glu Val Val Ala Gly Ile Pro Arg Thr Asp Gln Tyr Trp 
                325                 330                 335     


Glu Lys Ile 
            


<210>  54
<211>  3982
<212>  DNA
<213>  Homo sapiens

<400>  54
agggccgggg ctggcccagg ctacggcggc tgcagggctc cggcaaccgc tccggcaacg       60

ccaaccgctc cgctgcgcgc aggctgggct gcaggctctc ggctgcagcg ctgggctggt      120

gtgcagtggt gcgaccacgg ctcacggcag cctcagccac ccagatgtaa gcgatctggt      180

tcccacctca gcctcccgag tagatacttc tgaaaataga aatgatgact ctgggatgca      240

aacgttggct gtcctatgta taaggagatg gcttttcacg ctcccagtga ctgaggaagt      300

ttctcccaga tggcgctgct ctgagcctgg tgcagggtgg atctaggatc cggcttccaa      360

catgtggcag ctctgggcct ccctctgctg cctgctggtg ttggccaatg cccggagcag      420

gccctctttc catcccctgt cggatgagct ggtcaactat gtcaacaaac ggaataccac      480

gtggcaggcc gggcacaact tctacaacgt ggacatgagc tacttgaaga ggctatgtgg      540

taccttcctg ggtgggccca agccacccca gagagttatg tttaccgagg acctgaagct      600

gcctgcaagc ttcgatgcac gggaacaatg gccacagtgt cccaccatca aagagatcag      660

agaccagggc tcctgtggct cctgctgggc cttcggggct gtggaagcca tctctgaccg      720

gatctgcatc cacaccaatg cgcacgtcag cgtggaggtg tcggcggagg acctgctcac      780

atgctgtggc agcatgtgtg gggacggctg taatggtggc tatcctgctg aagcttggaa      840

cttctggaca agaaaaggcc tggtttctgg tggcctctat gaatcccatg tagggtgcag      900

accgtactcc atccctccct gtgagcacca cgtcaacggc tcccggcccc catgcacggg      960

ggagggagat acccccaagt gtagcaagat ctgtgagcct ggctacagcc cgacctacaa     1020

acaggacaag cactacggat acaattccta cagcgtctcc aatagcgaga aggacatcat     1080

ggccgagatc tacaaaaacg gccccgtgga gggagctttc tctgtgtatt cggacttcct     1140

gctctacaag tcaggagtgt accaacacgt caccggagag atgatgggtg gccatgccat     1200

ccgcatcctg ggctggggag tggagaatgg cacaccctac tggctggttg ccaactcctg     1260

gaacactgac tggggtgaca atggcttctt taaaatactc agaggacagg atcactgtgg     1320

aatcgaatca gaagtggtgg ctggaattcc acgcaccgat cagtactggg aaaagatcta     1380

atctgccgtg ggcctgtcgt gccagtcctg ggggcgagat cggggtagaa atgcatttta     1440

ttctttaagt tcacgtaaga tacaagtttc agacagggtc tgaaggactg gattggccaa     1500

acatcagacc tgtcttccaa ggagaccaag tcctggctac atcccagcct gtggttacag     1560

tgcagacagg ccatgtgagc caccgctgcc agcacagagc gtccttcccc ctgtagacta     1620

gtgccgtagg gagtacctgc tgccccagct gactgtggcc ccctccgtga tccatccatc     1680

tccagggagc aagacagaga cgcaggaatg gaaagcggag ttcctaacag gatgaaagtt     1740

cccccatcag ttcccccagt acctccaagc aagtagcttt ccacatttgt cacagaaatc     1800

agaggagaga cggtgttggg agccctttgg agaacgccag tctcccaggc cccctgcatc     1860

tatcgagttt gcaatgtcac aacctctctg atcttgtgct cagcatgatt ctttaataga     1920

agttttattt tttcgtgcac tctgctaatc atgtgggtga gccagtggaa cagcgggaga     1980

cctgtgctag ttttacagat tgcctcctta tgacgcggct caaaaggaaa ccaagtggtc     2040

aggagttgtt tctgacccac tgatctctac taccacaagg aaaatagttt aggagaaacc     2100

agcttttact gtttttgaaa aattacagct tcaccctgtc aagttaacaa ggaatgcctg     2160

tgccaataaa agttttctcc aacttgaagt ctactctgat gggatctcag atcctttgtc     2220

actgcctata gacttgtagc tgctgtctct ctttgtccct gcagagaatc acgtcctgga     2280

actgcatgtt cttgcgactc ttgggacttc atcttaactt ctcgctgccc cagccatgtt     2340

ttcaaccatg gcatccctcc cccaattagt tccctgtcat cctcgtcaac cttctctgta     2400

agtgcctggt aagcttgccc ttgcttaaga actcaaaaca tagctgtgct ctattttttt     2460

gttgttgttg tgactgacag agtgagattc cgtctcccag gctggagtgc agtggcgcct     2520

tctcagctca ctgcaacctg cagcctccta gattcaagcg attctcctgc ttcagccttc     2580

cgagtagctg ggatgacagg cactcaccaa tatgcctggg taatttttgt atttttaagt     2640

acatacagga tttcaccatg ttggccaggc tagtttcaaa ctcccggcct caggtggtct     2700

gcctgcctca gcctcccaaa gtgttgggat tacaggcgtg agccactggg ccctgcctgt     2760

attttttatc agccacaaat ccagcaacaa gctgaggatt cagctcataa aacaggcttg     2820

gtgtcttggt gatctcacat aaccaagatg ctaccccgtg gggaaccaca tccccctgga     2880

tgccctccag ccttggtttg ggctggagtc agggcctgta tacagtattt tgaatttgta     2940

tgccactggt ttgcattgct ggtcaggaac tctagtgctt tgcatagccc tggtttagaa     3000

acatgttata gcagttcttg gtatagagca aactagaaga accagcaatc attccactgt     3060

cctgccaagg tacacctcag tactcccctt cccaactgaa gtggtatgag gctagctctt     3120

tccaaaagca ttcaagtttg gcttctgatg tgactcagaa tttaggaacc agatgctaga     3180

tcaaataagc tctgaaaatc tgaggaacat tgtaggaaag gtttgttaag catctcttaa     3240

gtgccatgat gagcataaca gccggccgtc gtggctcacg cctgtaatcc cagcactttg     3300

ggaggccaag gtgggaggat gacaaggtca ggagttcaag accagcctgg ccaacatgct     3360

gaaacctcac ctctactaaa aatacaaaaa ttagctgggc atggtggcac atgcctgtaa     3420

tcccagctac ttgggaggct gaggcaggag aatcgcttga acccgggagg cggaggttgc     3480

agtgagccaa gacagtgcca gtgcactcca gcctcggtga cagcgcaagg ctccgtctca     3540

ataattaaaa aaaaaaaaaa aaaaaaaaag gccgggcgca gtggctcaag cctgtaatcc     3600

cagcactttg ggaggctgag gcgggcagat cacctgaggt caggagtttt gagatcagcc     3660

ttggcaacac ggtgaaaccc catctctact aaaaatacaa aattagccaa gcatgctggc     3720

acatgcctgt aatcccagct actcgggagg ctgaggtacg agaatcgctt gaacctggga     3780

ggcagaggat gcagtgagcc gagatcacgc cattgcactc cagcctgggg gacaagagtg     3840

aatctgtgtc tcaccaaaaa aaaaaagaaa aagaaagatg cttaacaaag gttaccataa     3900

gccacaaatt cataaccact tatccttcca gtttcaagta gaatatattc ataacctcaa     3960

taaagttctc cctgctccca aa                                              3982


<210>  55
<211>  339
<212>  PRT
<213>  Homo sapiens

<400>  55

Met Trp Gln Leu Trp Ala Ser Leu Cys Cys Leu Leu Val Leu Ala Asn 
1               5                   10                  15      


Ala Arg Ser Arg Pro Ser Phe His Pro Leu Ser Asp Glu Leu Val Asn 
            20                  25                  30          


Tyr Val Asn Lys Arg Asn Thr Thr Trp Gln Ala Gly His Asn Phe Tyr 
        35                  40                  45              


Asn Val Asp Met Ser Tyr Leu Lys Arg Leu Cys Gly Thr Phe Leu Gly 
    50                  55                  60                  


Gly Pro Lys Pro Pro Gln Arg Val Met Phe Thr Glu Asp Leu Lys Leu 
65                  70                  75                  80  


Pro Ala Ser Phe Asp Ala Arg Glu Gln Trp Pro Gln Cys Pro Thr Ile 
                85                  90                  95      


Lys Glu Ile Arg Asp Gln Gly Ser Cys Gly Ser Cys Trp Ala Phe Gly 
            100                 105                 110         


Ala Val Glu Ala Ile Ser Asp Arg Ile Cys Ile His Thr Asn Ala His 
        115                 120                 125             


Val Ser Val Glu Val Ser Ala Glu Asp Leu Leu Thr Cys Cys Gly Ser 
    130                 135                 140                 


Met Cys Gly Asp Gly Cys Asn Gly Gly Tyr Pro Ala Glu Ala Trp Asn 
145                 150                 155                 160 


Phe Trp Thr Arg Lys Gly Leu Val Ser Gly Gly Leu Tyr Glu Ser His 
                165                 170                 175     


Val Gly Cys Arg Pro Tyr Ser Ile Pro Pro Cys Glu His His Val Asn 
            180                 185                 190         


Gly Ser Arg Pro Pro Cys Thr Gly Glu Gly Asp Thr Pro Lys Cys Ser 
        195                 200                 205             


Lys Ile Cys Glu Pro Gly Tyr Ser Pro Thr Tyr Lys Gln Asp Lys His 
    210                 215                 220                 


Tyr Gly Tyr Asn Ser Tyr Ser Val Ser Asn Ser Glu Lys Asp Ile Met 
225                 230                 235                 240 


Ala Glu Ile Tyr Lys Asn Gly Pro Val Glu Gly Ala Phe Ser Val Tyr 
                245                 250                 255     


Ser Asp Phe Leu Leu Tyr Lys Ser Gly Val Tyr Gln His Val Thr Gly 
            260                 265                 270         


Glu Met Met Gly Gly His Ala Ile Arg Ile Leu Gly Trp Gly Val Glu 
        275                 280                 285             


Asn Gly Thr Pro Tyr Trp Leu Val Ala Asn Ser Trp Asn Thr Asp Trp 
    290                 295                 300                 


Gly Asp Asn Gly Phe Phe Lys Ile Leu Arg Gly Gln Asp His Cys Gly 
305                 310                 315                 320 


Ile Glu Ser Glu Val Val Ala Gly Ile Pro Arg Thr Asp Gln Tyr Trp 
                325                 330                 335     


Glu Lys Ile 
            


<210>  56
<211>  4086
<212>  DNA
<213>  Homo sapiens

<400>  56
caggaccgcc gagggaggcg cctgcgagga agagctcggc cgggtccgga gactgctgcc       60

tgggaccgcg ctcccagcgc ctgggcctcg gtgtctccgg gccaaactgc cgacataatc      120

gcatctgccg gcatctattt tcggtttatt tccccctcat tgcgaaggat ttgcctggcc      180

aactttctgc gcaagatccc acgcaattcc tgggacccca gaagacaggt cctgttgaag      240

aacaggaatc tggcactggg tgggctgggg aggaagccgc acggtgttaa atccataaac      300

aggaagagaa accagacagc gaaaccaaga ggcgaatggg cgattggatg ccggtgggga      360

gaaggccggg ggcgcaccct gctcctggac tccagtaaag ggaggccggg cagagtccct      420

ggggcgccac ctccccctcg gtggatctag gatccggctt ccaacatgtg gcagctctgg      480

gcctccctct gctgcctgct ggtgttggcc aatgcccgga gcaggccctc tttccatccc      540

ctgtcggatg agctggtcaa ctatgtcaac aaacggaata ccacgtggca ggccgggcac      600

aacttctaca acgtggacat gagctacttg aagaggctat gtggtacctt cctgggtggg      660

cccaagccac cccagagagt tatgtttacc gaggacctga agctgcctgc aagcttcgat      720

gcacgggaac aatggccaca gtgtcccacc atcaaagaga tcagagacca gggctcctgt      780

ggctcctgct gggccttcgg ggctgtggaa gccatctctg accggatctg catccacacc      840

aatgcgcacg tcagcgtgga ggtgtcggcg gaggacctgc tcacatgctg tggcagcatg      900

tgtggggacg gctgtaatgg tggctatcct gctgaagctt ggaacttctg gacaagaaaa      960

ggcctggttt ctggtggcct ctatgaatcc catgtagggt gcagaccgta ctccatccct     1020

ccctgtgagc accacgtcaa cggctcccgg cccccatgca cgggggaggg agataccccc     1080

aagtgtagca agatctgtga gcctggctac agcccgacct acaaacagga caagcactac     1140

ggatacaatt cctacagcgt ctccaatagc gagaaggaca tcatggccga gatctacaaa     1200

aacggccccg tggagggagc tttctctgtg tattcggact tcctgctcta caagtcagga     1260

gtgtaccaac acgtcaccgg agagatgatg ggtggccatg ccatccgcat cctgggctgg     1320

ggagtggaga atggcacacc ctactggctg gttgccaact cctggaacac tgactggggt     1380

gacaatggct tctttaaaat actcagagga caggatcact gtggaatcga atcagaagtg     1440

gtggctggaa ttccacgcac cgatcagtac tgggaaaaga tctaatctgc cgtgggcctg     1500

tcgtgccagt cctgggggcg agatcggggt agaaatgcat tttattcttt aagttcacgt     1560

aagatacaag tttcagacag ggtctgaagg actggattgg ccaaacatca gacctgtctt     1620

ccaaggagac caagtcctgg ctacatccca gcctgtggtt acagtgcaga caggccatgt     1680

gagccaccgc tgccagcaca gagcgtcctt ccccctgtag actagtgccg tagggagtac     1740

ctgctgcccc agctgactgt ggccccctcc gtgatccatc catctccagg gagcaagaca     1800

gagacgcagg aatggaaagc ggagttccta acaggatgaa agttccccca tcagttcccc     1860

cagtacctcc aagcaagtag ctttccacat ttgtcacaga aatcagagga gagacggtgt     1920

tgggagccct ttggagaacg ccagtctccc aggccccctg catctatcga gtttgcaatg     1980

tcacaacctc tctgatcttg tgctcagcat gattctttaa tagaagtttt attttttcgt     2040

gcactctgct aatcatgtgg gtgagccagt ggaacagcgg gagacctgtg ctagttttac     2100

agattgcctc cttatgacgc ggctcaaaag gaaaccaagt ggtcaggagt tgtttctgac     2160

ccactgatct ctactaccac aaggaaaata gtttaggaga aaccagcttt tactgttttt     2220

gaaaaattac agcttcaccc tgtcaagtta acaaggaatg cctgtgccaa taaaagtttt     2280

ctccaacttg aagtctactc tgatgggatc tcagatcctt tgtcactgcc tatagacttg     2340

tagctgctgt ctctctttgt ccctgcagag aatcacgtcc tggaactgca tgttcttgcg     2400

actcttggga cttcatctta acttctcgct gccccagcca tgttttcaac catggcatcc     2460

ctcccccaat tagttccctg tcatcctcgt caaccttctc tgtaagtgcc tggtaagctt     2520

gcccttgctt aagaactcaa aacatagctg tgctctattt ttttgttgtt gttgtgactg     2580

acagagtgag attccgtctc ccaggctgga gtgcagtggc gccttctcag ctcactgcaa     2640

cctgcagcct cctagattca agcgattctc ctgcttcagc cttccgagta gctgggatga     2700

caggcactca ccaatatgcc tgggtaattt ttgtattttt aagtacatac aggatttcac     2760

catgttggcc aggctagttt caaactcccg gcctcaggtg gtctgcctgc ctcagcctcc     2820

caaagtgttg ggattacagg cgtgagccac tgggccctgc ctgtattttt tatcagccac     2880

aaatccagca acaagctgag gattcagctc ataaaacagg cttggtgtct tggtgatctc     2940

acataaccaa gatgctaccc cgtggggaac cacatccccc tggatgccct ccagccttgg     3000

tttgggctgg agtcagggcc tgtatacagt attttgaatt tgtatgccac tggtttgcat     3060

tgctggtcag gaactctagt gctttgcata gccctggttt agaaacatgt tatagcagtt     3120

cttggtatag agcaaactag aagaaccagc aatcattcca ctgtcctgcc aaggtacacc     3180

tcagtactcc ccttcccaac tgaagtggta tgaggctagc tctttccaaa agcattcaag     3240

tttggcttct gatgtgactc agaatttagg aaccagatgc tagatcaaat aagctctgaa     3300

aatctgagga acattgtagg aaaggtttgt taagcatctc ttaagtgcca tgatgagcat     3360

aacagccggc cgtcgtggct cacgcctgta atcccagcac tttgggaggc caaggtggga     3420

ggatgacaag gtcaggagtt caagaccagc ctggccaaca tgctgaaacc tcacctctac     3480

taaaaataca aaaattagct gggcatggtg gcacatgcct gtaatcccag ctacttggga     3540

ggctgaggca ggagaatcgc ttgaacccgg gaggcggagg ttgcagtgag ccaagacagt     3600

gccagtgcac tccagcctcg gtgacagcgc aaggctccgt ctcaataatt aaaaaaaaaa     3660

aaaaaaaaaa aaaggccggg cgcagtggct caagcctgta atcccagcac tttgggaggc     3720

tgaggcgggc agatcacctg aggtcaggag ttttgagatc agccttggca acacggtgaa     3780

accccatctc tactaaaaat acaaaattag ccaagcatgc tggcacatgc ctgtaatccc     3840

agctactcgg gaggctgagg tacgagaatc gcttgaacct gggaggcaga ggatgcagtg     3900

agccgagatc acgccattgc actccagcct gggggacaag agtgaatctg tgtctcacca     3960

aaaaaaaaaa gaaaaagaaa gatgcttaac aaaggttacc ataagccaca aattcataac     4020

cacttatcct tccagtttca agtagaatat attcataacc tcaataaagt tctccctgct     4080

cccaaa                                                                4086


<210>  57
<211>  339
<212>  PRT
<213>  Homo sapiens

<400>  57

Met Trp Gln Leu Trp Ala Ser Leu Cys Cys Leu Leu Val Leu Ala Asn 
1               5                   10                  15      


Ala Arg Ser Arg Pro Ser Phe His Pro Leu Ser Asp Glu Leu Val Asn 
            20                  25                  30          


Tyr Val Asn Lys Arg Asn Thr Thr Trp Gln Ala Gly His Asn Phe Tyr 
        35                  40                  45              


Asn Val Asp Met Ser Tyr Leu Lys Arg Leu Cys Gly Thr Phe Leu Gly 
    50                  55                  60                  


Gly Pro Lys Pro Pro Gln Arg Val Met Phe Thr Glu Asp Leu Lys Leu 
65                  70                  75                  80  


Pro Ala Ser Phe Asp Ala Arg Glu Gln Trp Pro Gln Cys Pro Thr Ile 
                85                  90                  95      


Lys Glu Ile Arg Asp Gln Gly Ser Cys Gly Ser Cys Trp Ala Phe Gly 
            100                 105                 110         


Ala Val Glu Ala Ile Ser Asp Arg Ile Cys Ile His Thr Asn Ala His 
        115                 120                 125             


Val Ser Val Glu Val Ser Ala Glu Asp Leu Leu Thr Cys Cys Gly Ser 
    130                 135                 140                 


Met Cys Gly Asp Gly Cys Asn Gly Gly Tyr Pro Ala Glu Ala Trp Asn 
145                 150                 155                 160 


Phe Trp Thr Arg Lys Gly Leu Val Ser Gly Gly Leu Tyr Glu Ser His 
                165                 170                 175     


Val Gly Cys Arg Pro Tyr Ser Ile Pro Pro Cys Glu His His Val Asn 
            180                 185                 190         


Gly Ser Arg Pro Pro Cys Thr Gly Glu Gly Asp Thr Pro Lys Cys Ser 
        195                 200                 205             


Lys Ile Cys Glu Pro Gly Tyr Ser Pro Thr Tyr Lys Gln Asp Lys His 
    210                 215                 220                 


Tyr Gly Tyr Asn Ser Tyr Ser Val Ser Asn Ser Glu Lys Asp Ile Met 
225                 230                 235                 240 


Ala Glu Ile Tyr Lys Asn Gly Pro Val Glu Gly Ala Phe Ser Val Tyr 
                245                 250                 255     


Ser Asp Phe Leu Leu Tyr Lys Ser Gly Val Tyr Gln His Val Thr Gly 
            260                 265                 270         


Glu Met Met Gly Gly His Ala Ile Arg Ile Leu Gly Trp Gly Val Glu 
        275                 280                 285             


Asn Gly Thr Pro Tyr Trp Leu Val Ala Asn Ser Trp Asn Thr Asp Trp 
    290                 295                 300                 


Gly Asp Asn Gly Phe Phe Lys Ile Leu Arg Gly Gln Asp His Cys Gly 
305                 310                 315                 320 


Ile Glu Ser Glu Val Val Ala Gly Ile Pro Arg Thr Asp Gln Tyr Trp 
                325                 330                 335     


Glu Lys Ile 
            


<210>  58
<211>  1587
<212>  DNA
<213>  Homo sapiens

<400>  58
ggcggtgccg gccgaaccca gacccgaggt tttagaagca gagtcaggcg aagctgggcc       60

agaaccgcga cctccgcaac cttgagcggc atccgtggag tgcgcctgcg cagctacgac      120

cgcagcagga aagcgccgcc ggccaggccc agctgtggcc ggacagggac tggaagagag      180

gacgcggtcg agtaggtttt aaaacatgaa tcctacactc atccttgctg ccttttgcct      240

gggaattgcc tcagctactc taacatttga tcacagttta gaggcacagt ggaccaagtg      300

gaaggcgatg cacaacagat tatacggcat gaatgaagaa ggatggagga gagcagtgtg      360

ggagaagaac atgaagatga ttgaactgca caatcaggaa tacagggaag ggaaacacag      420

cttcacaatg gccatgaacg cctttggaga catgaccagt gaagaattca ggcaggtgat      480

gaatggcttt caaaaccgta agcccaggaa ggggaaagtg ttccaggaac ctctgtttta      540

tgaggccccc agatctgtgg attggagaga gaaaggctac gtgactcctg tgaagaatca      600

gggtcagtgt ggttcttgtt gggcttttag tgctactggt gctcttgaag gacagatgtt      660

ccggaaaact gggaggctta tctcactgag tgagcagaat ctggtagact gctctgggcc      720

tcaaggcaat gaaggctgca atggtggcct aatggattat gctttccagt atgttcagga      780

taatggaggc ctggactctg aggaatccta tccatatgag gcaacagaag aatcctgtaa      840

gtacaatccc aagtattctg ttgctaatga caccggcttt gtggacatcc ctaagcagga      900

gaaggccctg atgaaggcag ttgcaactgt ggggcccatt tctgttgcta ttgatgcagg      960

tcatgagtcc ttcctgttct ataaagaagg catttatttt gagccagact gtagcagtga     1020

agacatggat catggtgtgc tggtggttgg ctacggattt gaaagcacag aatcagataa     1080

caataaatat tggctggtga agaacagctg gggtgaagaa tggggcatgg gtggctacgt     1140

aaagatggcc aaagaccgga gaaaccattg tggaattgcc tcagcagcca gctaccccac     1200

tgtgtgagct ggtggacggt gatgaggaag gacttgactg gggatggcgc atgcatggga     1260

ggaattcatc ttcagtctac cagcccccgc tgtgtcggat acacactcga atcattgaag     1320

atccgagtgt gatttgaatt ctgtgatatt ttcacactgg taaatgttac ctctatttta     1380

attactgcta taaataggtt tatattattg attcacttac tgactttgca ttttcgtttt     1440

taaaaggatg tataaatttt tacctgttta aataaaattt aatttcaaat gtagtggtgg     1500

ggcttctttc tatttttgat gcactgaatt tttgtgtaat aaagaacata attgggctct     1560

aagccataaa aaaaaaaaaa aaaaaaa                                         1587


<210>  59
<211>  333
<212>  PRT
<213>  Homo sapiens

<400>  59

Met Asn Pro Thr Leu Ile Leu Ala Ala Phe Cys Leu Gly Ile Ala Ser 
1               5                   10                  15      


Ala Thr Leu Thr Phe Asp His Ser Leu Glu Ala Gln Trp Thr Lys Trp 
            20                  25                  30          


Lys Ala Met His Asn Arg Leu Tyr Gly Met Asn Glu Glu Gly Trp Arg 
        35                  40                  45              


Arg Ala Val Trp Glu Lys Asn Met Lys Met Ile Glu Leu His Asn Gln 
    50                  55                  60                  


Glu Tyr Arg Glu Gly Lys His Ser Phe Thr Met Ala Met Asn Ala Phe 
65                  70                  75                  80  


Gly Asp Met Thr Ser Glu Glu Phe Arg Gln Val Met Asn Gly Phe Gln 
                85                  90                  95      


Asn Arg Lys Pro Arg Lys Gly Lys Val Phe Gln Glu Pro Leu Phe Tyr 
            100                 105                 110         


Glu Ala Pro Arg Ser Val Asp Trp Arg Glu Lys Gly Tyr Val Thr Pro 
        115                 120                 125             


Val Lys Asn Gln Gly Gln Cys Gly Ser Cys Trp Ala Phe Ser Ala Thr 
    130                 135                 140                 


Gly Ala Leu Glu Gly Gln Met Phe Arg Lys Thr Gly Arg Leu Ile Ser 
145                 150                 155                 160 


Leu Ser Glu Gln Asn Leu Val Asp Cys Ser Gly Pro Gln Gly Asn Glu 
                165                 170                 175     


Gly Cys Asn Gly Gly Leu Met Asp Tyr Ala Phe Gln Tyr Val Gln Asp 
            180                 185                 190         


Asn Gly Gly Leu Asp Ser Glu Glu Ser Tyr Pro Tyr Glu Ala Thr Glu 
        195                 200                 205             


Glu Ser Cys Lys Tyr Asn Pro Lys Tyr Ser Val Ala Asn Asp Thr Gly 
    210                 215                 220                 


Phe Val Asp Ile Pro Lys Gln Glu Lys Ala Leu Met Lys Ala Val Ala 
225                 230                 235                 240 


Thr Val Gly Pro Ile Ser Val Ala Ile Asp Ala Gly His Glu Ser Phe 
                245                 250                 255     


Leu Phe Tyr Lys Glu Gly Ile Tyr Phe Glu Pro Asp Cys Ser Ser Glu 
            260                 265                 270         


Asp Met Asp His Gly Val Leu Val Val Gly Tyr Gly Phe Glu Ser Thr 
        275                 280                 285             


Glu Ser Asp Asn Asn Lys Tyr Trp Leu Val Lys Asn Ser Trp Gly Glu 
    290                 295                 300                 


Glu Trp Gly Met Gly Gly Tyr Val Lys Met Ala Lys Asp Arg Arg Asn 
305                 310                 315                 320 


His Cys Gly Ile Ala Ser Ala Ala Ser Tyr Pro Thr Val 
                325                 330             


<210>  60
<211>  1626
<212>  DNA
<213>  Homo sapiens

<400>  60
ggcggtgccg gccgaaccca gacccgaggt tttagaagca gagtcaggcg aagctgggcc       60

agaaccgcga cctccgcaac cttgagcggc atccgtggag tgcgcctgcg cagctacgac      120

cgcagcagga aagcgccgcc ggccaggccc agctgtggcc ggacagggac tggaagagag      180

gacgcggtcg agtaggtgtg caccagccct ggcaacgaga gcgtctaccc cgaactctgc      240

tggccttgag gttttaaaac atgaatccta cactcatcct tgctgccttt tgcctgggaa      300

ttgcctcagc tactctaaca tttgatcaca gtttagaggc acagtggacc aagtggaagg      360

cgatgcacaa cagattatac ggcatgaatg aagaaggatg gaggagagca gtgtgggaga      420

agaacatgaa gatgattgaa ctgcacaatc aggaatacag ggaagggaaa cacagcttca      480

caatggccat gaacgccttt ggagacatga ccagtgaaga attcaggcag gtgatgaatg      540

gctttcaaaa ccgtaagccc aggaagggga aagtgttcca ggaacctctg ttttatgagg      600

cccccagatc tgtggattgg agagagaaag gctacgtgac tcctgtgaag aatcagggtc      660

agtgtggttc ttgttgggct tttagtgcta ctggtgctct tgaaggacag atgttccgga      720

aaactgggag gcttatctca ctgagtgagc agaatctggt agactgctct gggcctcaag      780

gcaatgaagg ctgcaatggt ggcctaatgg attatgcttt ccagtatgtt caggataatg      840

gaggcctgga ctctgaggaa tcctatccat atgaggcaac agaagaatcc tgtaagtaca      900

atcccaagta ttctgttgct aatgacaccg gctttgtgga catccctaag caggagaagg      960

ccctgatgaa ggcagttgca actgtggggc ccatttctgt tgctattgat gcaggtcatg     1020

agtccttcct gttctataaa gaaggcattt attttgagcc agactgtagc agtgaagaca     1080

tggatcatgg tgtgctggtg gttggctacg gatttgaaag cacagaatca gataacaata     1140

aatattggct ggtgaagaac agctggggtg aagaatgggg catgggtggc tacgtaaaga     1200

tggccaaaga ccggagaaac cattgtggaa ttgcctcagc agccagctac cccactgtgt     1260

gagctggtgg acggtgatga ggaaggactt gactggggat ggcgcatgca tgggaggaat     1320

tcatcttcag tctaccagcc cccgctgtgt cggatacaca ctcgaatcat tgaagatccg     1380

agtgtgattt gaattctgtg atattttcac actggtaaat gttacctcta ttttaattac     1440

tgctataaat aggtttatat tattgattca cttactgact ttgcattttc gtttttaaaa     1500

ggatgtataa atttttacct gtttaaataa aatttaattt caaatgtagt ggtggggctt     1560

ctttctattt ttgatgcact gaatttttgt gtaataaaga acataattgg gctctaagcc     1620

ataaaa                                                                1626


<210>  61
<211>  333
<212>  PRT
<213>  Homo sapiens

<400>  61

Met Asn Pro Thr Leu Ile Leu Ala Ala Phe Cys Leu Gly Ile Ala Ser 
1               5                   10                  15      


Ala Thr Leu Thr Phe Asp His Ser Leu Glu Ala Gln Trp Thr Lys Trp 
            20                  25                  30          


Lys Ala Met His Asn Arg Leu Tyr Gly Met Asn Glu Glu Gly Trp Arg 
        35                  40                  45              


Arg Ala Val Trp Glu Lys Asn Met Lys Met Ile Glu Leu His Asn Gln 
    50                  55                  60                  


Glu Tyr Arg Glu Gly Lys His Ser Phe Thr Met Ala Met Asn Ala Phe 
65                  70                  75                  80  


Gly Asp Met Thr Ser Glu Glu Phe Arg Gln Val Met Asn Gly Phe Gln 
                85                  90                  95      


Asn Arg Lys Pro Arg Lys Gly Lys Val Phe Gln Glu Pro Leu Phe Tyr 
            100                 105                 110         


Glu Ala Pro Arg Ser Val Asp Trp Arg Glu Lys Gly Tyr Val Thr Pro 
        115                 120                 125             


Val Lys Asn Gln Gly Gln Cys Gly Ser Cys Trp Ala Phe Ser Ala Thr 
    130                 135                 140                 


Gly Ala Leu Glu Gly Gln Met Phe Arg Lys Thr Gly Arg Leu Ile Ser 
145                 150                 155                 160 


Leu Ser Glu Gln Asn Leu Val Asp Cys Ser Gly Pro Gln Gly Asn Glu 
                165                 170                 175     


Gly Cys Asn Gly Gly Leu Met Asp Tyr Ala Phe Gln Tyr Val Gln Asp 
            180                 185                 190         


Asn Gly Gly Leu Asp Ser Glu Glu Ser Tyr Pro Tyr Glu Ala Thr Glu 
        195                 200                 205             


Glu Ser Cys Lys Tyr Asn Pro Lys Tyr Ser Val Ala Asn Asp Thr Gly 
    210                 215                 220                 


Phe Val Asp Ile Pro Lys Gln Glu Lys Ala Leu Met Lys Ala Val Ala 
225                 230                 235                 240 


Thr Val Gly Pro Ile Ser Val Ala Ile Asp Ala Gly His Glu Ser Phe 
                245                 250                 255     


Leu Phe Tyr Lys Glu Gly Ile Tyr Phe Glu Pro Asp Cys Ser Ser Glu 
            260                 265                 270         


Asp Met Asp His Gly Val Leu Val Val Gly Tyr Gly Phe Glu Ser Thr 
        275                 280                 285             


Glu Ser Asp Asn Asn Lys Tyr Trp Leu Val Lys Asn Ser Trp Gly Glu 
    290                 295                 300                 


Glu Trp Gly Met Gly Gly Tyr Val Lys Met Ala Lys Asp Arg Arg Asn 
305                 310                 315                 320 


His Cys Gly Ile Ala Ser Ala Ala Ser Tyr Pro Thr Val 
                325                 330             


<210>  62
<211>  1567
<212>  DNA
<213>  Homo sapiens

<400>  62
ggcggtgccg gccgaaccca gacccgaggt tttagaagca gagtcaggcg aagctgggcc       60

agaaccgcga cctccgcaac cttgagcggc atccgtggag tgcgcctgcg cagctacgac      120

cgcagcagga aagcgccgcc ggccaggccc agctgtggcc ggacagggac tggaagagag      180

gacgcggtcg agttttaaaa catgaatcct acactcatcc ttgctgcctt ttgcctggga      240

attgcctcag ctactctaac atttgatcac agtttagagg cacagtggac caagtggaag      300

gcgatgcaca acagattata cggcatgaat gaagaaggat ggaggagagc agtgtgggag      360

aagaacatga agatgattga actgcacaat caggaataca gggaagggaa acacagcttc      420

acaatggcca tgaacgcctt tggagacatg accagtgaag aattcaggca ggtgatgaat      480

ggctttcaaa accgtaagcc caggaagggg aaagtgttcc aggaacctct gttttatgag      540

gcccccagat ctgtggattg gagagagaaa ggctacgtga ctcctgtgaa gaatcagggt      600

cagtgtggtt cttgttgggc ttttagtgct actggtgctc ttgaaggaca gatgttccgg      660

aaaactggga ggcttatctc actgagtgag cagaatctgg tagactgctc tgggcctcaa      720

ggcaatgaag gctgcaatgg tggcctaatg gattatgctt tccagtatgt tcaggataat      780

ggaggcctgg actctgagga atcctatcca tatgaggcaa cagaagaatc ctgtaagtac      840

aatcccaagt attctgttgc taatgacacc ggctttgtgg acatccctaa gcaggagaag      900

gccctgatga aggcagttgc aactgtgggg cccatttctg ttgctattga tgcaggtcat      960

gagtccttcc tgttctataa agaaggcatt tattttgagc cagactgtag cagtgaagac     1020

atggatcatg gtgtgctggt ggttggctac ggatttgaaa gcacagaatc agataacaat     1080

aaatattggc tggtgaagaa cagctggggt gaagaatggg gcatgggtgg ctacgtaaag     1140

atggccaaag accggagaaa ccattgtgga attgcctcag cagccagcta ccccactgtg     1200

tgagctggtg gacggtgatg aggaaggact tgactgggga tggcgcatgc atgggaggaa     1260

ttcatcttca gtctaccagc ccccgctgtg tcggatacac actcgaatca ttgaagatcc     1320

gagtgtgatt tgaattctgt gatattttca cactggtaaa tgttacctct attttaatta     1380

ctgctataaa taggtttata ttattgattc acttactgac tttgcatttt cgtttttaaa     1440

aggatgtata aatttttacc tgtttaaata aaatttaatt tcaaatgtag tggtggggct     1500

tctttctatt tttgatgcac tgaatttttg tgtaataaag aacataattg ggctctaagc     1560

cataaaa                                                               1567


<210>  63
<211>  333
<212>  PRT
<213>  Homo sapiens

<400>  63

Met Asn Pro Thr Leu Ile Leu Ala Ala Phe Cys Leu Gly Ile Ala Ser 
1               5                   10                  15      


Ala Thr Leu Thr Phe Asp His Ser Leu Glu Ala Gln Trp Thr Lys Trp 
            20                  25                  30          


Lys Ala Met His Asn Arg Leu Tyr Gly Met Asn Glu Glu Gly Trp Arg 
        35                  40                  45              


Arg Ala Val Trp Glu Lys Asn Met Lys Met Ile Glu Leu His Asn Gln 
    50                  55                  60                  


Glu Tyr Arg Glu Gly Lys His Ser Phe Thr Met Ala Met Asn Ala Phe 
65                  70                  75                  80  


Gly Asp Met Thr Ser Glu Glu Phe Arg Gln Val Met Asn Gly Phe Gln 
                85                  90                  95      


Asn Arg Lys Pro Arg Lys Gly Lys Val Phe Gln Glu Pro Leu Phe Tyr 
            100                 105                 110         


Glu Ala Pro Arg Ser Val Asp Trp Arg Glu Lys Gly Tyr Val Thr Pro 
        115                 120                 125             


Val Lys Asn Gln Gly Gln Cys Gly Ser Cys Trp Ala Phe Ser Ala Thr 
    130                 135                 140                 


Gly Ala Leu Glu Gly Gln Met Phe Arg Lys Thr Gly Arg Leu Ile Ser 
145                 150                 155                 160 


Leu Ser Glu Gln Asn Leu Val Asp Cys Ser Gly Pro Gln Gly Asn Glu 
                165                 170                 175     


Gly Cys Asn Gly Gly Leu Met Asp Tyr Ala Phe Gln Tyr Val Gln Asp 
            180                 185                 190         


Asn Gly Gly Leu Asp Ser Glu Glu Ser Tyr Pro Tyr Glu Ala Thr Glu 
        195                 200                 205             


Glu Ser Cys Lys Tyr Asn Pro Lys Tyr Ser Val Ala Asn Asp Thr Gly 
    210                 215                 220                 


Phe Val Asp Ile Pro Lys Gln Glu Lys Ala Leu Met Lys Ala Val Ala 
225                 230                 235                 240 


Thr Val Gly Pro Ile Ser Val Ala Ile Asp Ala Gly His Glu Ser Phe 
                245                 250                 255     


Leu Phe Tyr Lys Glu Gly Ile Tyr Phe Glu Pro Asp Cys Ser Ser Glu 
            260                 265                 270         


Asp Met Asp His Gly Val Leu Val Val Gly Tyr Gly Phe Glu Ser Thr 
        275                 280                 285             


Glu Ser Asp Asn Asn Lys Tyr Trp Leu Val Lys Asn Ser Trp Gly Glu 
    290                 295                 300                 


Glu Trp Gly Met Gly Gly Tyr Val Lys Met Ala Lys Asp Arg Arg Asn 
305                 310                 315                 320 


His Cys Gly Ile Ala Ser Ala Ala Ser Tyr Pro Thr Val 
                325                 330             


<210>  64
<211>  1141
<212>  DNA
<213>  Homo sapiens

<400>  64
ggcggtgccg gccgaaccca gacccgaggt tttagaagca gagtcaggcg aagctgggcc       60

agaaccgcga cctccgcaac cttgagcggc atccgtggag tgcgcctgcg cagctacgac      120

cgcagcagga aagcgccgcc ggccaggccc agctgtggcc ggacagggac tggaagagag      180

gacgcggtcg agtaggtttt aaaacatgaa tcctacactc atccttgctg ccttttgcct      240

gggaattgcc tcagctactc taacatttga tcacagttta gaggcacagt ggaccaagtg      300

gaaggctgca atggtggcct aatggattat gctttccagt atgttcagga taatggaggc      360

ctggactctg aggaatccta tccatatgag gcaacagaag aatcctgtaa gtacaatccc      420

aagtattctg ttgctaatga caccggcttt gtggacatcc ctaagcagga gaaggccctg      480

atgaaggcag ttgcaactgt ggggcccatt tctgttgcta ttgatgcagg tcatgagtcc      540

ttcctgttct ataaagaagg catttatttt gagccagact gtagcagtga agacatggat      600

catggtgtgc tggtggttgg ctacggattt gaaagcacag aatcagataa caataaatat      660

tggctggtga agaacagctg gggtgaagaa tggggcatgg gtggctacgt aaagatggcc      720

aaagaccgga gaaaccattg tggaattgcc tcagcagcca gctaccccac tgtgtgagct      780

ggtggacggt gatgaggaag gacttgactg gggatggcgc atgcatggga ggaattcatc      840

ttcagtctac cagcccccgc tgtgtcggat acacactcga atcattgaag atccgagtgt      900

gatttgaatt ctgtgatatt ttcacactgg taaatgttac ctctatttta attactgcta      960

taaataggtt tatattattg attcacttac tgactttgca ttttcgtttt taaaaggatg     1020

tataaatttt tacctgttta aataaaattt aatttcaaat gtagtggtgg ggcttctttc     1080

tatttttgat gcactgaatt tttgtgtaat aaagaacata attgggctct aagccataaa     1140

a                                                                     1141


<210>  65
<211>  151
<212>  PRT
<213>  Homo sapiens

<400>  65

Met Asp Tyr Ala Phe Gln Tyr Val Gln Asp Asn Gly Gly Leu Asp Ser 
1               5                   10                  15      


Glu Glu Ser Tyr Pro Tyr Glu Ala Thr Glu Glu Ser Cys Lys Tyr Asn 
            20                  25                  30          


Pro Lys Tyr Ser Val Ala Asn Asp Thr Gly Phe Val Asp Ile Pro Lys 
        35                  40                  45              


Gln Glu Lys Ala Leu Met Lys Ala Val Ala Thr Val Gly Pro Ile Ser 
    50                  55                  60                  


Val Ala Ile Asp Ala Gly His Glu Ser Phe Leu Phe Tyr Lys Glu Gly 
65                  70                  75                  80  


Ile Tyr Phe Glu Pro Asp Cys Ser Ser Glu Asp Met Asp His Gly Val 
                85                  90                  95      


Leu Val Val Gly Tyr Gly Phe Glu Ser Thr Glu Ser Asp Asn Asn Lys 
            100                 105                 110         


Tyr Trp Leu Val Lys Asn Ser Trp Gly Glu Glu Trp Gly Met Gly Gly 
        115                 120                 125             


Tyr Val Lys Met Ala Lys Asp Arg Arg Asn His Cys Gly Ile Ala Ser 
    130                 135                 140                 


Ala Ala Ser Tyr Pro Thr Val 
145                 150     


<210>  66
<211>  1401
<212>  DNA
<213>  Homo sapiens

<400>  66
acagctctgg acaggctgct tttcattttg gtgagtccat ccagtacctc cacgtgccct       60

gtttttctcc aggcacatcc ttggcctctt ccacagtcct tgggttttaa aacatgaatc      120

ctacactcat ccttgctgcc ttttgcctgg gaattgcctc agctactcta acatttgatc      180

acagtttaga ggcacagtgg accaagtgga aggcgatgca caacagatta tacggcatga      240

atgaagaagg atggaggaga gcagtgtggg agaagaacat gaagatgatt gaactgcaca      300

atcaggaata cagggaaggg aaacacagct tcacaatggc catgaacgcc tttggagaca      360

tgaccagtga agaattcagg caggtgatga atggctttca aaaccgtaag cccaggaagg      420

ggaaagtgtt ccaggaacct ctgttttatg aggcccccag atctgtggat tggagagaga      480

aaggctacgt gactcctgtg aagaatcagg gtcagtgtgg ttcttgttgg gcttttagtg      540

ctactggtgc tcttgaagga cagatgttcc ggaaaactgg gaggcttatc tcactgagtg      600

agcagaatct ggtagactgc tctgggcctc aaggcaatga aggctgcaat ggtggcctaa      660

tggattatgc tttccagtat gttcaggata atggaggcct ggactctgag gaatcctatc      720

catatgaggc aacagaagaa tcctgtaagt acaatcccaa gtattctgtt gctaatgaca      780

ccggctttgt ggacatccct aagcaggaga aggccctgat gaaggcagtt gcaactgtgg      840

ggcccatttc tgttgctatt gatgcaggtc atgagtcctt cctgttctat aaagaaggca      900

tttattttga gccagactgt agcagtgaag acatggatca tggtgtgctg gtggttggct      960

acggatttga aagcacagaa tcagataaca ataaatattg gctggtgaag aacagctggg     1020

gtgaagaatg gggcatgggt ggctacgtaa agatggccaa agaccggaga aaccattgtg     1080

gaattgcctc agcagccagc taccccactg tgtgagctgg tggacggtga tgaggaagga     1140

cttgactggg gatggcgcat gcatgggagg aattcatctt cagtctacca gcccccgctg     1200

tgtcggatac acactcgaat cattgaagat ccgagtgtga tttgaattct gtgatatttt     1260

cacactggta aatgttacct ctattttaat tactgctata aataggttta tattattgat     1320

tcacttactg actttgcatt ttcgttttta aaaggatgta taaattttta cctgtttaaa     1380

taaaatttaa tttcaaatgt a                                               1401


<210>  67
<211>  333
<212>  PRT
<213>  Homo sapiens

<400>  67

Met Asn Pro Thr Leu Ile Leu Ala Ala Phe Cys Leu Gly Ile Ala Ser 
1               5                   10                  15      


Ala Thr Leu Thr Phe Asp His Ser Leu Glu Ala Gln Trp Thr Lys Trp 
            20                  25                  30          


Lys Ala Met His Asn Arg Leu Tyr Gly Met Asn Glu Glu Gly Trp Arg 
        35                  40                  45              


Arg Ala Val Trp Glu Lys Asn Met Lys Met Ile Glu Leu His Asn Gln 
    50                  55                  60                  


Glu Tyr Arg Glu Gly Lys His Ser Phe Thr Met Ala Met Asn Ala Phe 
65                  70                  75                  80  


Gly Asp Met Thr Ser Glu Glu Phe Arg Gln Val Met Asn Gly Phe Gln 
                85                  90                  95      


Asn Arg Lys Pro Arg Lys Gly Lys Val Phe Gln Glu Pro Leu Phe Tyr 
            100                 105                 110         


Glu Ala Pro Arg Ser Val Asp Trp Arg Glu Lys Gly Tyr Val Thr Pro 
        115                 120                 125             


Val Lys Asn Gln Gly Gln Cys Gly Ser Cys Trp Ala Phe Ser Ala Thr 
    130                 135                 140                 


Gly Ala Leu Glu Gly Gln Met Phe Arg Lys Thr Gly Arg Leu Ile Ser 
145                 150                 155                 160 


Leu Ser Glu Gln Asn Leu Val Asp Cys Ser Gly Pro Gln Gly Asn Glu 
                165                 170                 175     


Gly Cys Asn Gly Gly Leu Met Asp Tyr Ala Phe Gln Tyr Val Gln Asp 
            180                 185                 190         


Asn Gly Gly Leu Asp Ser Glu Glu Ser Tyr Pro Tyr Glu Ala Thr Glu 
        195                 200                 205             


Glu Ser Cys Lys Tyr Asn Pro Lys Tyr Ser Val Ala Asn Asp Thr Gly 
    210                 215                 220                 


Phe Val Asp Ile Pro Lys Gln Glu Lys Ala Leu Met Lys Ala Val Ala 
225                 230                 235                 240 


Thr Val Gly Pro Ile Ser Val Ala Ile Asp Ala Gly His Glu Ser Phe 
                245                 250                 255     


Leu Phe Tyr Lys Glu Gly Ile Tyr Phe Glu Pro Asp Cys Ser Ser Glu 
            260                 265                 270         


Asp Met Asp His Gly Val Leu Val Val Gly Tyr Gly Phe Glu Ser Thr 
        275                 280                 285             


Glu Ser Asp Asn Asn Lys Tyr Trp Leu Val Lys Asn Ser Trp Gly Glu 
    290                 295                 300                 


Glu Trp Gly Met Gly Gly Tyr Val Lys Met Ala Lys Asp Arg Arg Asn 
305                 310                 315                 320 


His Cys Gly Ile Ala Ser Ala Ala Ser Tyr Pro Thr Val 
                325                 330             


<210>  68
<211>  412
<212>  PRT
<213>  Homo sapiens

<400>  68

Met Gln Pro Ser Ser Leu Leu Pro Leu Ala Leu Cys Leu Leu Ala Ala 
1               5                   10                  15      


Pro Ala Ser Ala Leu Val Arg Ile Pro Leu His Lys Phe Thr Ser Ile 
            20                  25                  30          


Arg Arg Thr Met Ser Glu Val Gly Gly Ser Val Glu Asp Leu Ile Ala 
        35                  40                  45              


Lys Gly Pro Val Ser Lys Tyr Ser Gln Ala Val Pro Ala Val Thr Glu 
    50                  55                  60                  


Gly Pro Ile Pro Glu Val Leu Lys Asn Tyr Met Asp Ala Gln Tyr Tyr 
65                  70                  75                  80  


Gly Glu Ile Gly Ile Gly Thr Pro Pro Gln Cys Phe Thr Val Val Phe 
                85                  90                  95      


Asp Thr Gly Ser Ser Asn Leu Trp Val Pro Ser Ile His Cys Lys Leu 
            100                 105                 110         


Leu Asp Ile Ala Cys Trp Ile His His Lys Tyr Asn Ser Asp Lys Ser 
        115                 120                 125             


Ser Thr Tyr Val Lys Asn Gly Thr Ser Phe Asp Ile His Tyr Gly Ser 
    130                 135                 140                 


Gly Ser Leu Ser Gly Tyr Leu Ser Gln Asp Thr Val Ser Val Pro Cys 
145                 150                 155                 160 


Gln Ser Ala Ser Ser Ala Ser Ala Leu Gly Gly Val Lys Val Glu Arg 
                165                 170                 175     


Gln Val Phe Gly Glu Ala Thr Lys Gln Pro Gly Ile Thr Phe Ile Ala 
            180                 185                 190         


Ala Lys Phe Asp Gly Ile Leu Gly Met Ala Tyr Pro Arg Ile Ser Val 
        195                 200                 205             


Asn Asn Val Leu Pro Val Phe Asp Asn Leu Met Gln Gln Lys Leu Val 
    210                 215                 220                 


Asp Gln Asn Ile Phe Ser Phe Tyr Leu Ser Arg Asp Pro Asp Ala Gln 
225                 230                 235                 240 


Pro Gly Gly Glu Leu Met Leu Gly Gly Thr Asp Ser Lys Tyr Tyr Lys 
                245                 250                 255     


Gly Ser Leu Ser Tyr Leu Asn Val Thr Arg Lys Ala Tyr Trp Gln Val 
            260                 265                 270         


His Leu Asp Gln Val Glu Val Ala Ser Gly Leu Thr Leu Cys Lys Glu 
        275                 280                 285             


Gly Cys Glu Ala Ile Val Asp Thr Gly Thr Ser Leu Met Val Gly Pro 
    290                 295                 300                 


Val Asp Glu Val Arg Glu Leu Gln Lys Ala Ile Gly Ala Val Pro Leu 
305                 310                 315                 320 


Ile Gln Gly Glu Tyr Met Ile Pro Cys Glu Lys Val Ser Thr Leu Pro 
                325                 330                 335     


Ala Ile Thr Leu Lys Leu Gly Gly Lys Gly Tyr Lys Leu Ser Pro Glu 
            340                 345                 350         


Asp Tyr Thr Leu Lys Val Ser Gln Ala Gly Lys Thr Leu Cys Leu Ser 
        355                 360                 365             


Gly Phe Met Gly Met Asp Ile Pro Pro Pro Ser Gly Pro Leu Trp Ile 
    370                 375                 380                 


Leu Gly Asp Val Phe Ile Gly Arg Tyr Tyr Thr Val Phe Asp Arg Asp 
385                 390                 395                 400 


Asn Asn Arg Val Gly Phe Ala Glu Ala Ala Arg Leu 
                405                 410         


<210>  69
<211>  401
<212>  PRT
<213>  Homo sapiens

<400>  69

Met Lys Thr Leu Leu Leu Leu Leu Leu Val Leu Leu Glu Leu Gly Glu 
1               5                   10                  15      


Ala Gln Gly Ser Leu His Arg Val Pro Leu Arg Arg His Pro Ser Leu 
            20                  25                  30          


Lys Lys Lys Leu Arg Ala Arg Ser Gln Leu Ser Glu Phe Trp Lys Ser 
        35                  40                  45              


His Asn Leu Asp Met Ile Gln Phe Thr Glu Ser Cys Ser Met Asp Gln 
    50                  55                  60                  


Ser Ala Lys Glu Pro Leu Ile Asn Tyr Leu Asp Met Glu Tyr Phe Gly 
65                  70                  75                  80  


Thr Ile Ser Ile Gly Ser Pro Pro Gln Asn Phe Thr Val Ile Phe Asp 
                85                  90                  95      


Thr Gly Ser Ser Asn Leu Trp Val Pro Ser Val Tyr Cys Thr Ser Pro 
            100                 105                 110         


Ala Cys Lys Thr His Ser Arg Phe Gln Pro Ser Gln Ser Ser Thr Tyr 
        115                 120                 125             


Ser Gln Pro Gly Gln Ser Phe Ser Ile Gln Tyr Gly Thr Gly Ser Leu 
    130                 135                 140                 


Ser Gly Ile Ile Gly Ala Asp Gln Val Ser Ala Phe Ala Thr Gln Val 
145                 150                 155                 160 


Glu Gly Leu Thr Val Val Gly Gln Gln Phe Gly Glu Ser Val Thr Glu 
                165                 170                 175     


Pro Gly Gln Thr Phe Val Asp Ala Glu Phe Asp Gly Ile Leu Gly Leu 
            180                 185                 190         


Gly Tyr Pro Ser Leu Ala Val Gly Gly Val Thr Pro Val Phe Asp Asn 
        195                 200                 205             


Met Met Ala Gln Asn Leu Val Asp Leu Pro Met Phe Ser Val Tyr Met 
    210                 215                 220                 


Ser Ser Asn Pro Glu Gly Gly Ala Gly Ser Glu Leu Ile Phe Gly Gly 
225                 230                 235                 240 


Tyr Asp His Ser His Phe Ser Gly Ser Leu Asn Trp Val Pro Val Thr 
                245                 250                 255     


Lys Gln Ala Tyr Trp Gln Ile Ala Leu Asp Asn Ile Gln Val Gly Gly 
            260                 265                 270         


Thr Val Met Phe Cys Ser Glu Gly Cys Gln Ala Ile Val Asp Thr Gly 
        275                 280                 285             


Thr Ser Leu Ile Thr Gly Pro Ser Asp Lys Ile Lys Gln Leu Gln Asn 
    290                 295                 300                 


Ala Ile Gly Ala Ala Pro Val Asp Gly Glu Tyr Ala Val Glu Cys Ala 
305                 310                 315                 320 


Asn Leu Asn Val Met Pro Asp Val Thr Phe Thr Ile Asn Gly Val Pro 
                325                 330                 335     


Tyr Thr Leu Ser Pro Thr Ala Tyr Thr Leu Leu Asp Phe Val Asp Gly 
            340                 345                 350         


Met Gln Phe Cys Ser Ser Gly Phe Gln Gly Leu Asp Ile His Pro Pro 
        355                 360                 365             


Ala Gly Pro Leu Trp Ile Leu Gly Asp Val Phe Ile Arg Gln Phe Tyr 
    370                 375                 380                 


Ser Val Phe Asp Arg Gly Asn Asn Arg Val Gly Leu Ala Pro Ala Val 
385                 390                 395                 400 


Pro 
    


<210>  70
<211>  396
<212>  PRT
<213>  Homo sapiens

<400>  70

Met Lys Thr Leu Leu Leu Leu Leu Leu Val Leu Leu Glu Leu Gly Glu 
1               5                   10                  15      


Ala Gln Gly Ser Leu His Arg Val Pro Leu Arg Arg His Pro Ser Leu 
            20                  25                  30          


Lys Lys Lys Leu Arg Ala Arg Ser Gln Leu Ser Glu Phe Trp Lys Ser 
        35                  40                  45              


His Asn Leu Asp Met Ile Gln Phe Thr Glu Ser Cys Ser Met Asp Gln 
    50                  55                  60                  


Ser Ala Lys Glu Pro Leu Ile Asn Tyr Leu Asp Met Glu Tyr Phe Gly 
65                  70                  75                  80  


Thr Ile Ser Ile Gly Ser Pro Pro Gln Asn Phe Thr Val Ile Phe Asp 
                85                  90                  95      


Thr Gly Ser Ser Asn Leu Trp Val Pro Ser Val Tyr Cys Thr Ser Pro 
            100                 105                 110         


Ala Cys Lys Thr His Ser Arg Phe Gln Pro Ser Gln Ser Ser Thr Tyr 
        115                 120                 125             


Ser Gln Pro Gly Gln Ser Phe Ser Ile Gln Tyr Gly Thr Gly Ser Leu 
    130                 135                 140                 


Ser Gly Ile Ile Gly Ala Asp Gln Val Ser Val Glu Gly Leu Thr Val 
145                 150                 155                 160 


Val Gly Gln Gln Phe Gly Glu Ser Val Thr Glu Pro Gly Gln Thr Phe 
                165                 170                 175     


Val Asp Ala Glu Phe Asp Gly Ile Leu Gly Leu Gly Tyr Pro Ser Leu 
            180                 185                 190         


Ala Val Gly Gly Val Thr Pro Val Phe Asp Asn Met Met Ala Gln Asn 
        195                 200                 205             


Leu Val Asp Leu Pro Met Phe Ser Val Tyr Met Ser Ser Asn Pro Glu 
    210                 215                 220                 


Gly Gly Ala Gly Ser Glu Leu Ile Phe Gly Gly Tyr Asp His Ser His 
225                 230                 235                 240 


Phe Ser Gly Ser Leu Asn Trp Val Pro Val Thr Lys Gln Ala Tyr Trp 
                245                 250                 255     


Gln Ile Ala Leu Asp Asn Ile Gln Val Gly Gly Thr Val Met Phe Cys 
            260                 265                 270         


Ser Glu Gly Cys Gln Ala Ile Val Asp Thr Gly Thr Ser Leu Ile Thr 
        275                 280                 285             


Gly Pro Ser Asp Lys Ile Lys Gln Leu Gln Asn Ala Ile Gly Ala Ala 
    290                 295                 300                 


Pro Val Asp Gly Glu Tyr Ala Val Glu Cys Ala Asn Leu Asn Val Met 
305                 310                 315                 320 


Pro Asp Val Thr Phe Thr Ile Asn Gly Val Pro Tyr Thr Leu Ser Pro 
                325                 330                 335     


Thr Ala Tyr Thr Leu Leu Asp Phe Val Asp Gly Met Gln Phe Cys Ser 
            340                 345                 350         


Ser Gly Phe Gln Gly Leu Asp Ile His Pro Pro Ala Gly Pro Leu Trp 
        355                 360                 365             


Ile Leu Gly Asp Val Phe Ile Arg Gln Phe Tyr Ser Val Phe Asp Arg 
    370                 375                 380                 


Gly Asn Asn Arg Val Gly Leu Ala Pro Ala Val Pro 
385                 390                 395     


<210>  71
<211>  363
<212>  PRT
<213>  Homo sapiens

<400>  71

Met Lys Thr Leu Leu Leu Leu Leu Leu Val Leu Leu Glu Leu Gly Glu 
1               5                   10                  15      


Ala Gln Gly Ser Leu His Arg Val Pro Leu Arg Arg His Pro Ser Leu 
            20                  25                  30          


Lys Lys Lys Leu Arg Ala Arg Ser Gln Leu Ser Glu Phe Trp Lys Ser 
        35                  40                  45              


His Asn Leu Asp Met Ile Gln Phe Thr Glu Ser Cys Ser Met Asp Gln 
    50                  55                  60                  


Ser Ala Lys Glu Pro Leu Ile Asn Tyr Leu Asp Met Glu Tyr Phe Gly 
65                  70                  75                  80  


Thr Ile Ser Ile Gly Ser Pro Pro Gln Asn Phe Thr Val Ile Phe Asp 
                85                  90                  95      


Thr Gly Ser Ser Asn Leu Trp Val Pro Ser Val Tyr Cys Thr Ser Pro 
            100                 105                 110         


Ala Cys Lys Thr His Ser Arg Phe Gln Pro Ser Gln Ser Ser Thr Tyr 
        115                 120                 125             


Ser Gln Pro Gly Gln Ser Phe Ser Ile Gln Tyr Gly Thr Gly Ser Leu 
    130                 135                 140                 


Ser Gly Ile Ile Gly Ala Asp Gln Val Ser Val Glu Gly Leu Thr Val 
145                 150                 155                 160 


Val Gly Gln Gln Phe Gly Glu Ser Val Thr Glu Pro Gly Gln Thr Phe 
                165                 170                 175     


Val Asp Ala Glu Phe Asp Gly Ile Leu Gly Leu Gly Tyr Pro Ser Leu 
            180                 185                 190         


Ala Val Gly Gly Val Thr Pro Val Phe Asp Asn Met Met Ala Gln Asn 
        195                 200                 205             


Leu Val Asp Leu Pro Met Phe Ser Val Tyr Met Ser Ser Asn Pro Glu 
    210                 215                 220                 


Gly Gly Ala Gly Ser Glu Leu Ile Phe Gly Gly Tyr Asp His Ser His 
225                 230                 235                 240 


Phe Ser Gly Ser Leu Asn Trp Val Pro Val Thr Lys Gln Ala Tyr Trp 
                245                 250                 255     


Gln Ile Ala Leu Asp Asn Met Leu Trp Ser Val Pro Thr Leu Thr Ser 
            260                 265                 270         


Cys Arg Met Ser Pro Ser Pro Leu Thr Glu Ser Pro Ile Pro Ser Ala 
        275                 280                 285             


Gln Leu Pro Thr Pro Tyr Trp Thr Ser Trp Met Glu Cys Ser Ser Ala 
    290                 295                 300                 


Ala Val Ala Phe Lys Asp Leu Thr Ser Thr Leu Gln Leu Gly Pro Ser 
305                 310                 315                 320 


Gly Ser Trp Gly Met Ser Ser Phe Asp Ser Phe Thr Gln Ser Leu Thr 
                325                 330                 335     


Val Gly Ile Thr Val Trp Asp Trp Pro Gln Gln Ser Pro Lys Glu Gly 
            340                 345                 350         


Pro Cys Val Cys Ala Cys Leu Ser Asp Arg Pro 
        355                 360             


<210>  72
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Substrate competitive inhibitor, L803-mts


<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  May be N-terminally myristoylated

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  May be a phosphorylated residue

<400>  72

Gly Lys Glu Ala Pro Pro Ala Pro Pro Gln Ser Pro 
1               5                   10          


