                               SEQUENCE LISTING

<110> SHAH, KARTIK KIRAN
      MUNSHI, AMIT DILIP
 
<120> METHODS OF TREATING NEURODEGENERATIVE CONDITIONS

<130> 107653-1460

<140>
<141>

<150> 62/247,680
<151> 2015-10-28

<160> 41    

<170> PatentIn version 3.5

<210> 1
<211> 28
<212> PRT
<213> Homo sapiens

<400> 1
Gly Ser Ser Phe Leu Ser Pro Glu His Gln Arg Val Gln Gln Arg Lys 
1               5                   10                  15      


Glu Ser Lys Lys Pro Pro Ala Lys Leu Gln Pro Arg 
            20                  25              


<210> 2
<211> 23
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 2
Gly Ser Ser Phe Leu Ser Pro Glu His Gln Arg Val Gln Val Arg Pro 
1               5                   10                  15      


Pro Lys Ala Pro His Val Val 
            20              


<210> 3
<211> 24
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (3)..(3)
<223> 2,3-diaminopropionic acid; optionally octanoylated 

<400> 3
Gly Ser Xaa Phe Leu Ser Pro Glu His Gln Arg Val Gln Val Arg Pro 
1               5                   10                  15      


Pro His Lys Ala Pro His Val Val 
            20                  


<210> 4
<211> 24
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (2)..(2)
<223> 2,3-diaminopropionic acid 

<220>
<221> MOD_RES
<222> (3)..(3)
<223> 2,3-diaminopropionic acid; optionally octanoylated 

<400> 4
Gly Xaa Xaa Phe Leu Ser Pro Glu His Gln Arg Val Gln Val Arg Pro 
1               5                   10                  15      


Pro His Lys Ala Pro His Val Val 
            20                  


<210> 5
<211> 28
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 5
Gly Ser Ser Phe Leu Ser Pro Glu His Gln Arg Val Gln Val Arg Pro 
1               5                   10                  15      


Pro His Lys Ala Pro His Val Val Pro Ala Leu Pro 
            20                  25              


<210> 6
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (1)..(1) 
<223> Isonipecotic acid-D-2Nal

<220>
<221> MOD_RES
<222> (2)..(2) 
<223> D-Trp

<220>
<221> source
<223> /note="C-term NH2"

<400> 6
Xaa Trp Thr Lys 
1               


<210> 7
<211> 144
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 7
Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu 
1               5                   10                  15      


Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly 
            20                  25                  30          


Ser Glu Thr Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu 
        35                  40                  45              


Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Glu Pro 
    50                  55                  60                  


Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Glu Pro Ala Thr Ser Gly 
65                  70                  75                  80  


Ser Glu Thr Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro 
                85                  90                  95      


Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu 
            100                 105                 110         


Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly 
        115                 120                 125             


Ser Glu Thr Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 
    130                 135                 140                 


<210> 8
<211> 84
<212> DNA
<213> Homo sapiens

<400> 8
ggctccagct tcctgagccc tgaacaccag agagtccagc agagaaagga gtcgaagaag       60

ccaccagcca agctgcagcc ccga                                              84


<210> 9
<211> 29
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 9
Gly Ser Ser Phe Leu Ser Pro Glu His Gln Arg Val Gln Val Arg Pro 
1               5                   10                  15      


Pro His Lys Ala Pro His Val Val Pro Ala Leu Pro Leu 
            20                  25                  


<210> 10
<211> 94
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 10
Gly Ser Ser Phe Leu Ser Pro Glu His Gln Arg Val Gln Val Arg Pro 
1               5                   10                  15      


Pro His Lys Ala Pro His Val Val Pro Ala Leu Pro Leu Ser Asn Gln 
            20                  25                  30          


Leu Cys Asp Leu Glu Gln Gln Arg His Leu Trp Ala Ser Val Phe Ser 
        35                  40                  45              


Gln Ser Thr Lys Asp Ser Gly Ser Asp Leu Thr Val Ser Gly Arg Thr 
    50                  55                  60                  


Trp Gly Leu Arg Val Leu Asn Gln Leu Phe Pro Pro Ser Ser Arg Glu 
65                  70                  75                  80  


Arg Ser Arg Arg Ser His Gln Pro Ser Cys Ser Pro Glu Leu 
                85                  90                  


<210> 11
<211> 4
<212> PRT
<213> Homo sapiens

<400> 11
Gly Ser Ser Phe 
1               


<210> 12
<211> 5
<212> PRT
<213> Homo sapiens

<400> 12
Gly Ser Ser Phe Leu 
1               5   


<210> 13
<211> 6
<212> PRT
<213> Homo sapiens

<400> 13
Gly Ser Ser Phe Leu Ser 
1               5       


<210> 14
<211> 7
<212> PRT
<213> Homo sapiens

<400> 14
Gly Ser Ser Phe Leu Ser Pro 
1               5           


<210> 15
<211> 8
<212> PRT
<213> Homo sapiens

<400> 15
Gly Ser Ser Phe Leu Ser Pro Glu 
1               5               


<210> 16
<211> 9
<212> PRT
<213> Homo sapiens

<400> 16
Gly Ser Ser Phe Leu Ser Pro Glu His 
1               5                   


<210> 17
<211> 10
<212> PRT
<213> Homo sapiens

<400> 17
Gly Ser Ser Phe Leu Ser Pro Glu His Gln 
1               5                   10  


<210> 18
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 18
Gly Ser Ser Phe Leu Ser Pro Ser Gln Lys Pro Gln Asn Lys Val Lys 
1               5                   10                  15      


Ser Ser Arg Ile 
            20  


<210> 19
<211> 28
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 19
Gly Ser Ser Phe Leu Ser Pro Glu His Gln Lys Ala Gln Gln Arg Lys 
1               5                   10                  15      


Glu Ser Lys Lys Pro Pro Ala Lys Leu Gln Pro Arg 
            20                  25              


<210> 20
<211> 28
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 20
Gly Ser Ser Phe Leu Ser Pro Glu His Gln Lys Val Gln Gln Arg Lys 
1               5                   10                  15      


Glu Ser Lys Lys Pro Ala Ala Lys Leu Lys Pro Arg 
            20                  25              


<210> 21
<211> 28
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 21
Gly Ser Ser Phe Leu Ser Pro Glu His Gln Arg Ala Gln Gln Arg Lys 
1               5                   10                  15      


Glu Ser Lys Lys Pro Pro Ala Lys Leu Gln Pro Arg 
            20                  25              


<210> 22
<211> 26
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 22
Gly Ser Ser Phe Leu Ser Pro Thr Tyr Lys Asn Ile Gln Gln Gln Lys 
1               5                   10                  15      


Asp Thr Arg Lys Pro Thr Ala Arg Leu His 
            20                  25      


<210> 23
<211> 28
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 23
Gly Ser Ser Phe Leu Ser Pro Glu His Gln Lys Leu Gln Gln Arg Lys 
1               5                   10                  15      


Glu Ser Lys Lys Pro Pro Ala Lys Leu Gln Pro Arg 
            20                  25              


<210> 24
<211> 28
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (3)..(3) 
<223> Ser(O-n-octanoyl)

<400> 24
Gly Ser Ser Phe Leu Ser Pro Glu His Gln Arg Val Gln Gln Arg Lys 
1               5                   10                  15      


Glu Ser Lys Lys Pro Pro Ala Lys Leu Gln Pro Arg 
            20                  25              


<210> 25
<211> 29
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Fluorescein-Ahx 

<220>
<221> MOD_RES
<222> (4)..(4) 
<223> Ser(O-n-octanoyl)

<400> 25
Xaa Gly Ser Ser Phe Leu Ser Pro Glu His Gln Arg Val Gln Gln Arg 
1               5                   10                  15      


Lys Glu Ser Lys Lys Pro Pro Ala Lys Leu Gln Pro Arg 
            20                  25                  


<210> 26
<211> 28
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (3)..(3) 
<223> Ser(O-n-octanoyl)

<400> 26
Gly Ser Ser Tyr Leu Ser Pro Glu His Gln Arg Val Gln Gln Arg Lys 
1               5                   10                  15      


Glu Ser Lys Lys Pro Pro Ala Lys Leu Gln Pro Arg 
            20                  25              


<210> 27
<211> 107
<212> PRT
<213> Rattus sp.

<400> 27
Met Glu Glu Lys Val Glu Asp Asp Phe Leu Asp Leu Asp Ala Val Pro 
1               5                   10                  15      


Glu Thr Pro Val Phe Asp Cys Val Met Asp Ile Lys Pro Glu Thr Asp 
            20                  25                  30          


Pro Ala Ser Leu Thr Val Lys Ser Met Gly Leu Gln Glu Arg Arg Gly 
        35                  40                  45              


Ser Asn Val Ser Leu Thr Leu Asp Met Cys Thr Pro Gly Cys Asn Glu 
    50                  55                  60                  


Glu Gly Phe Gly Tyr Leu Val Ser Pro Arg Glu Glu Ser Ala His Glu 
65                  70                  75                  80  


Tyr Leu Leu Ser Ala Ser Arg Val Leu Arg Ala Glu Glu Leu His Glu 
                85                  90                  95      


Lys Ala Leu Asp Pro Phe Leu Leu Gln Ala Glu 
            100                 105         


<210> 28
<211> 107
<212> PRT
<213> Homo sapiens

<400> 28
Met Glu Glu Lys Ile Glu Asp Asp Phe Leu Asp Leu Asp Pro Val Pro 
1               5                   10                  15      


Glu Thr Pro Val Phe Asp Cys Val Met Asp Ile Lys Pro Glu Ala Asp 
            20                  25                  30          


Pro Thr Ser Leu Thr Val Lys Ser Met Gly Leu Gln Glu Arg Arg Gly 
        35                  40                  45              


Ser Asn Val Ser Leu Thr Leu Asp Met Cys Thr Pro Gly Cys Asn Glu 
    50                  55                  60                  


Glu Gly Phe Gly Tyr Leu Met Ser Pro Arg Glu Glu Ser Ala Arg Glu 
65                  70                  75                  80  


Tyr Leu Leu Ser Ala Ser Arg Val Leu Gln Ala Glu Glu Leu His Glu 
                85                  90                  95      


Lys Ala Leu Asp Pro Phe Leu Leu Gln Ala Glu 
            100                 105         


<210> 29
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 29
Met Glu Glu Lys Ile Glu Asp Asp Phe Leu Asp Leu Asp Pro Val Pro 
1               5                   10                  15      


Glu Thr Pro Val Phe Asp Cys Val Met Asp Ile Lys Pro Glu Ala Asp 
            20                  25                  30          


Pro Thr Ser Leu Thr Val Lys Ser Met Gly Leu Gln Glu Arg Arg Gly 
        35                  40                  45              


Ala Asn Val Ser Leu Thr Leu Asp Met Cys Thr Pro Gly Cys Asn Glu 
    50                  55                  60                  


Glu Gly Phe Gly Tyr Leu Met Ser Pro Arg Glu Glu Ser Ala Arg Glu 
65                  70                  75                  80  


Tyr Leu Leu Ser Ala Ser Arg Val Leu Gln Ala Glu Glu Leu His Glu 
                85                  90                  95      


Lys Ala Leu Asp Pro Phe Leu Leu Gln Ala Glu 
            100                 105         


<210> 30
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 30
Met Glu Glu Lys Ile Glu Asp Asp Phe Leu Asp Leu Asp Pro Val Pro 
1               5                   10                  15      


Glu Thr Pro Val Phe Asp Cys Val Met Asp Ile Lys Pro Glu Ala Asp 
            20                  25                  30          


Pro Thr Ser Leu Thr Val Lys Ser Met Gly Leu Gln Glu Arg Arg Gly 
        35                  40                  45              


Ala Asn Val Ser Leu Thr Leu Asp Met Cys Glu Pro Gly Cys Asn Glu 
    50                  55                  60                  


Glu Gly Phe Gly Tyr Leu Met Glu Pro Arg Glu Glu Ser Ala Arg Glu 
65                  70                  75                  80  


Tyr Leu Leu Ser Ala Ser Arg Val Leu Gln Ala Glu Glu Leu His Glu 
                85                  90                  95      


Lys Ala Leu Asp Pro Phe Leu Leu Gln Ala Glu 
            100                 105         


<210> 31
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 31
Met Glu Glu Lys Ile Glu Asp Asp Phe Leu Asp Leu Asp Pro Val Pro 
1               5                   10                  15      


Glu Thr Pro Val Phe Asp Ala Val Met Asp Ile Lys Pro Glu Ala Asp 
            20                  25                  30          


Pro Thr Ser Leu Thr Val Lys Ser Met Gly Leu Gln Glu Arg Arg Gly 
        35                  40                  45              


Ser Asn Val Ser Leu Thr Leu Asp Met Cys Thr Pro Gly Cys Asn Glu 
    50                  55                  60                  


Glu Gly Phe Gly Tyr Leu Met Ser Pro Arg Glu Glu Ser Ala Arg Glu 
65                  70                  75                  80  


Tyr Leu Leu Ser Ala Ser Arg Val Leu Gln Ala Glu Glu Leu His Glu 
                85                  90                  95      


Lys Ala Leu Asp Pro Phe Leu Leu Gln Ala Glu 
            100                 105         


<210> 32
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 32
Met Glu Glu Lys Ile Glu Asp Asp Phe Leu Asp Leu Asp Pro Val Pro 
1               5                   10                  15      


Glu Glu Pro Val Phe Asp Cys Val Met Asp Ile Lys Pro Glu Ala Asp 
            20                  25                  30          


Pro Thr Ser Leu Thr Val Lys Ser Met Gly Leu Gln Glu Arg Arg Gly 
        35                  40                  45              


Ser Asn Val Ser Leu Thr Leu Asp Met Cys Thr Pro Gly Cys Asn Glu 
    50                  55                  60                  


Glu Gly Phe Gly Tyr Leu Met Ser Pro Arg Glu Glu Ser Ala Arg Glu 
65                  70                  75                  80  


Tyr Leu Leu Ser Ala Ser Arg Val Leu Gln Ala Glu Glu Leu His Glu 
                85                  90                  95      


Lys Ala Leu Asp Pro Phe Leu Leu Gln Ala Glu 
            100                 105         


<210> 33
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 33
Met Glu Glu Lys Ile Glu Asp Asp Phe Leu Asp Leu Asp Pro Val Pro 
1               5                   10                  15      


Glu Ala Pro Val Phe Asp Cys Val Met Asp Ile Lys Pro Glu Ala Asp 
            20                  25                  30          


Pro Thr Ser Leu Thr Val Lys Ser Met Gly Leu Gln Glu Arg Arg Gly 
        35                  40                  45              


Ser Asn Val Ser Leu Thr Leu Asp Met Cys Thr Pro Gly Cys Asn Glu 
    50                  55                  60                  


Glu Gly Phe Gly Tyr Leu Met Ser Pro Arg Glu Glu Ser Ala Arg Glu 
65                  70                  75                  80  


Tyr Leu Leu Ser Ala Ser Arg Val Leu Gln Ala Glu Glu Leu His Glu 
                85                  90                  95      


Lys Ala Leu Asp Pro Phe Leu Leu Gln Ala Glu 
            100                 105         


<210> 34
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 34
Met Glu Glu Lys Ile Glu Asp Asp Phe Leu Asp Leu Asp Pro Val Pro 
1               5                   10                  15      


Glu Glu Pro Val Phe Asp Ala Val Met Asp Ile Lys Pro Glu Ala Asp 
            20                  25                  30          


Pro Thr Ser Leu Thr Val Lys Ser Met Gly Leu Gln Glu Arg Arg Gly 
        35                  40                  45              


Ala Asn Val Ser Leu Thr Leu Asp Met Cys Glu Pro Gly Cys Asn Glu 
    50                  55                  60                  


Glu Gly Phe Gly Tyr Leu Met Glu Pro Arg Glu Glu Ser Ala Arg Glu 
65                  70                  75                  80  


Tyr Leu Leu Ser Ala Ser Arg Val Leu Gln Ala Glu Glu Leu His Glu 
                85                  90                  95      


Lys Ala Leu Asp Pro Phe Leu Leu Gln Ala Glu 
            100                 105         


<210> 35
<211> 121
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 35
Met Ala Leu Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Gly Glu 
1               5                   10                  15      


Glu Lys Ile Glu Asp Asp Phe Leu Asp Leu Asp Pro Val Pro Glu Thr 
            20                  25                  30          


Pro Val Phe Asp Cys Val Met Asp Ile Lys Pro Glu Ala Asp Pro Thr 
        35                  40                  45              


Ser Leu Thr Val Lys Ser Met Gly Leu Gln Glu Arg Arg Gly Ala Asn 
    50                  55                  60                  


Val Ser Leu Thr Leu Asp Met Cys Glu Pro Gly Cys Asn Glu Glu Gly 
65                  70                  75                  80  


Phe Gly Tyr Leu Met Glu Pro Arg Glu Glu Ser Ala Arg Glu Tyr Leu 
                85                  90                  95      


Leu Ser Ala Ser Arg Val Leu Gln Ala Glu Glu Leu His Glu Lys Ala 
            100                 105                 110         


Leu Asp Pro Phe Leu Leu Gln Ala Glu 
        115                 120     


<210> 36
<211> 121
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 36
Met Ala Leu Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Gly Glu 
1               5                   10                  15      


Glu Lys Val Glu Asp Asp Phe Leu Asp Leu Asp Ala Val Pro Glu Thr 
            20                  25                  30          


Pro Val Phe Asp Cys Val Met Asp Ile Lys Pro Glu Thr Asp Pro Ala 
        35                  40                  45              


Ser Leu Thr Val Lys Ser Met Gly Leu Gln Glu Arg Arg Gly Ala Asn 
    50                  55                  60                  


Val Ser Leu Thr Leu Asp Met Cys Glu Pro Gly Cys Asn Glu Glu Gly 
65                  70                  75                  80  


Phe Gly Tyr Leu Val Glu Pro Arg Glu Glu Ser Ala His Glu Tyr Leu 
                85                  90                  95      


Leu Ser Ala Ser Arg Val Leu Arg Ala Glu Glu Leu His Glu Lys Ala 
            100                 105                 110         


Leu Asp Pro Phe Leu Leu Gln Ala Glu 
        115                 120     


<210> 37
<211> 22
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> source
<223> /note="C-term NH2"

<400> 37
Gly Ile Gly Lys Phe Leu Lys Lys Ala Lys Lys Phe Gly Lys Ala Phe 
1               5                   10                  15      


Val Lys Ile Leu Lys Lys 
            20          


<210> 38
<211> 28
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (3)..(3) 
<223> Ser(O-(C=O)-(CH2)6-CH3)

<400> 38
Gly Ser Ser Phe Leu Ser Pro Glu His Gln Lys Ala Gln Gln Arg Lys 
1               5                   10                  15      


Glu Ser Lys Lys Pro Pro Ala Lys Leu Gln Pro Arg 
            20                  25              


<210> 39

<400> 39
000


<210> 40

<400> 40
000


<210> 41
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (3)..(3) 
<223> Ser(n-octanoyl)

<400> 41
Gly Ser Ser Phe 
1               


