                               SEQUENCE LISTING

<110> ALETA BIOTHERAPEUTICS INC.
 
<120> COMPOSITIONS AND METHODS FOR TUMOR TRANSDUCTION

<130> 2012106-0008

<140> PCT/US2016/059578
<141> 2016-10-28

<150> 62/249,183
<151> 2015-10-30

<160> 8     

<170> PatentIn version 3.5

<210> 1
<211> 553
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1
Met Pro Pro Pro Arg Leu Leu Phe Phe Leu Leu Phe Leu Thr Pro Met 
1               5                   10                  15      


Glu Val Arg Pro Glu Glu Pro Leu Val Val Lys Val Glu Glu Gly Asp 
            20                  25                  30          


Asn Ala Val Leu Gln Cys Leu Lys Gly Thr Ser Asp Gly Pro Thr Gln 
        35                  40                  45              


Gln Leu Thr Trp Ser Arg Glu Ser Pro Leu Lys Pro Phe Leu Lys Leu 
    50                  55                  60                  


Ser Leu Gly Leu Pro Gly Leu Gly Ile His Met Arg Pro Leu Ala Ile 
65                  70                  75                  80  


Trp Leu Phe Ile Phe Asn Val Ser Gln Gln Met Gly Gly Phe Tyr Leu 
                85                  90                  95      


Cys Gln Pro Gly Pro Pro Ser Glu Lys Ala Trp Gln Pro Gly Trp Thr 
            100                 105                 110         


Val Asn Val Glu Gly Ser Gly Glu Leu Phe Arg Trp Asn Val Ser Asp 
        115                 120                 125             


Leu Gly Gly Leu Gly Cys Gly Leu Lys Asn Arg Ser Ser Glu Gly Pro 
    130                 135                 140                 


Ser Ser Pro Ser Gly Lys Leu Met Ser Pro Lys Leu Tyr Val Trp Ala 
145                 150                 155                 160 


Lys Asp Arg Pro Glu Ile Trp Glu Gly Glu Pro Pro Cys Leu Pro Pro 
                165                 170                 175     


Arg Asp Ser Leu Asn Gln Ser Leu Ser Gln Asp Leu Thr Met Ala Pro 
            180                 185                 190         


Gly Ser Thr Leu Trp Leu Ser Cys Gly Val Pro Pro Asp Ser Val Ser 
        195                 200                 205             


Arg Gly Pro Leu Ser Trp Thr His Val His Pro Lys Gly Pro Lys Ser 
    210                 215                 220                 


Leu Leu Ser Leu Glu Leu Lys Asp Asp Arg Pro Ala Arg Asp Met Trp 
225                 230                 235                 240 


Val Met Glu Thr Gly Leu Leu Leu Pro Arg Ala Thr Ala Gln Asp Ala 
                245                 250                 255     


Gly Lys Tyr Tyr Cys His Arg Gly Asn Leu Thr Met Ser Phe His Leu 
            260                 265                 270         


Glu Ile Thr Ala Arg Pro Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        275                 280                 285             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu 
    290                 295                 300                 


Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
305                 310                 315                 320 


Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr Tyr Ile His Trp Val Arg 
                325                 330                 335     


Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Tyr Pro Thr 
            340                 345                 350         


Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
        355                 360                 365             


Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu 
    370                 375                 380                 


Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ser Arg Trp Gly Gly Asp 
385                 390                 395                 400 


Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
                405                 410                 415     


Ser Ser Ala Ser Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
            420                 425                 430         


Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
        435                 440                 445             


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp 
    450                 455                 460                 


Val Asn Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
465                 470                 475                 480 


Lys Leu Leu Ile Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser 
                485                 490                 495     


Arg Phe Ser Gly Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
            500                 505                 510         


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr 
        515                 520                 525             


Thr Thr Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
    530                 535                 540                 


Thr Ser Arg His His His His His His 
545                 550             


<210> 2
<211> 1659
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 2
atgccacctc ctcgcctcct cttcttcctc ctcttcctca cccccatgga agtcaggccc       60

gaggaacctc tagtggtgaa ggtggaagag ggagataacg ctgtgctgca gtgcctcaag      120

gggacctcag atggccccac tcagcagctg acctggtctc gggagtcccc gcttaaaccc      180

ttcttaaaac tcagcctggg gctgccaggc ctgggaatcc acatgaggcc cctggccatc      240

tggcttttca tcttcaacgt ctctcaacag atggggggct tctacctgtg ccagccgggg      300

cccccctctg agaaggcctg gcagcctggc tggacagtca atgtggaggg cagcggggag      360

ctgttccggt ggaatgtttc ggacctaggt ggcctgggct gtggcctgaa gaacaggtcc      420

tcagagggcc ccagctcccc ttccgggaag ctcatgagcc ccaagctgta tgtgtgggcc      480

aaagaccgcc ctgagatctg ggagggagag cctccgtgtc tcccaccgag ggacagcctg      540

aaccagagcc tcagccagga cctcaccatg gcccctggct ccacactctg gctgtcctgt      600

ggggtacccc ctgactctgt gtccaggggc cccctctcct ggacccatgt gcaccccaag      660

gggcctaagt cattgctgag cctagagctg aaggacgatc gcccggccag agatatgtgg      720

gtaatggaga cgggtctgtt gttgccccgg gccacagctc aagacgctgg aaagtattat      780

tgtcaccgtg gcaacctgac catgtcattc cacctggaga tcactgctcg gccaggggga      840

ggtgggtctg gaggtggagg atctggtgga ggtgggtctg gtggaggtgg gtctgaggtg      900

cagctggtgg agtctggtgg tggtcttgtt caacctggtg gttctcttcg tctttcttgt      960

gctgcttctg gttttaatat taaagatact tatattcatt gggttcgtca agctcctggt     1020

aaaggtcttg aatgggttgc tcgtatttat cctactaatg gttatactcg ttatgctgat     1080

tctgttaaag gtcgttttac tatttctgct gatacttcta aaaatactgc ttatcttcaa     1140

atgaactctc ttcgtgctga agatactgct gtttattatt gttctcgttg gggtggtgat     1200

ggtttttatg ctatggatta ttggggtcaa ggtactcttg tcaccgtctc ctcagctagc     1260

accgggggag gtgggtctgg aggtggagga tctggtggag gtgggtctga catccagatg     1320

acccagtctc cttcttctct ttctgcttct gttggtgatc gtgttactat tacttgtcgt     1380

gcttctcaag atgttaatac tgctgttgct tggtatcaac aaaaacctgg taaagctcct     1440

aaacttctta tttattctgc ttcttttctt tattctggtg ttccttctcg tttttctggt     1500

tctcgttctg gtactgattt tactcttact atttcttctc ttcaacctga agattttgct     1560

acttattatt gtcaacaaca ttatactact cctcctactt ttggtcaagg taccaaggtg     1620

gagatcaaac gtacgtctag acatcatcac catcaccat                            1659


<210> 3
<211> 557
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3
Met Pro Pro Pro Arg Leu Leu Phe Phe Leu Leu Phe Leu Thr Pro Met 
1               5                   10                  15      


Glu Val Arg Pro Glu Glu Pro Leu Val Val Lys Val Glu Glu Gly Asp 
            20                  25                  30          


Asn Ala Val Leu Gln Cys Leu Lys Gly Thr Ser Asp Gly Pro Thr Gln 
        35                  40                  45              


Gln Leu Thr Trp Ser Arg Glu Ser Pro Leu Lys Pro Phe Leu Lys Leu 
    50                  55                  60                  


Ser Leu Gly Leu Pro Gly Leu Gly Ile His Met Arg Pro Leu Ala Ile 
65                  70                  75                  80  


Trp Leu Phe Ile Phe Asn Val Ser Gln Gln Met Gly Gly Phe Tyr Leu 
                85                  90                  95      


Cys Gln Pro Gly Pro Pro Ser Glu Lys Ala Trp Gln Pro Gly Trp Thr 
            100                 105                 110         


Val Asn Val Glu Gly Ser Gly Glu Leu Phe Arg Trp Asn Val Ser Asp 
        115                 120                 125             


Leu Gly Gly Leu Gly Cys Gly Leu Lys Asn Arg Ser Ser Glu Gly Pro 
    130                 135                 140                 


Ser Ser Pro Ser Gly Lys Leu Met Ser Pro Lys Leu Tyr Val Trp Ala 
145                 150                 155                 160 


Lys Asp Arg Pro Glu Ile Trp Glu Gly Glu Pro Pro Cys Leu Pro Pro 
                165                 170                 175     


Arg Asp Ser Leu Asn Gln Ser Leu Ser Gln Asp Leu Thr Met Ala Pro 
            180                 185                 190         


Gly Ser Thr Leu Trp Leu Ser Cys Gly Val Pro Pro Asp Ser Val Ser 
        195                 200                 205             


Arg Gly Pro Leu Ser Trp Thr His Val His Pro Lys Gly Pro Lys Ser 
    210                 215                 220                 


Leu Leu Ser Leu Glu Leu Lys Asp Asp Arg Pro Ala Arg Asp Met Trp 
225                 230                 235                 240 


Val Met Glu Thr Gly Leu Leu Leu Pro Arg Ala Thr Ala Gln Asp Ala 
                245                 250                 255     


Gly Lys Tyr Tyr Cys His Arg Gly Asn Leu Thr Met Ser Phe His Leu 
            260                 265                 270         


Glu Ile Thr Ala Arg Pro Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        275                 280                 285             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Val Gln 
    290                 295                 300                 


Ser Gly Ala Glu Asp Lys Lys Pro Gly Glu Ser Val Lys Ile Ser Cys 
305                 310                 315                 320 


Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr Gly Met Asn Trp Val Arg 
                325                 330                 335     


Gln Ala Pro Gly Gln Gly Leu Lys Trp Met Gly Trp Ile Asn Thr Tyr 
            340                 345                 350         


Thr Gly Glu Ser Thr Tyr Ala Asp Asp Phe Lys Gly Arg Phe Ala Phe 
        355                 360                 365             


Ser Leu Asp Thr Ser Ala Ser Thr Ala Tyr Leu Gln Leu Ser Ser Leu 
    370                 375                 380                 


Arg Gly Glu Asp Thr Ala Val Tyr Phe Cys Ala Arg Phe Ala Ile Lys 
385                 390                 395                 400 


Gly Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser 
                405                 410                 415     


Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            420                 425                 430         


Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu 
        435                 440                 445             


Glu Val Ser Pro Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser Thr Lys 
    450                 455                 460                 


Ser Leu Leu His Ser Asp Gly Ile Thr Tyr Leu Tyr Trp Tyr Leu Gln 
465                 470                 475                 480 


Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Gln Leu Ser Asn Leu 
                485                 490                 495     


Ala Ser Gly Val Pro Asp Arg Phe Ser Ser Ser Gly Ser Gly Thr Asp 
            500                 505                 510         


Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Glu Gly Thr Tyr 
        515                 520                 525             


Tyr Cys Ala Gln Asn Leu Glu Ile Pro Arg Thr Phe Gly Gln Gly Thr 
    530                 535                 540                 


Lys Leu Glu Ile Lys Arg Thr His His His His His His 
545                 550                 555         


<210> 4
<211> 1671
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 4
atgccacctc ctcgcctcct cttcttcctc ctcttcctca cccccatgga agtcaggccc       60

gaggaacctc tagtggtgaa ggtggaagag ggagataacg ctgtgctgca gtgcctcaag      120

gggacctcag atggccccac tcagcagctg acctggtctc gggagtcccc gcttaaaccc      180

ttcttaaaac tcagcctggg gctgccaggc ctgggaatcc acatgaggcc cctggccatc      240

tggcttttca tcttcaacgt ctctcaacag atggggggct tctacctgtg ccagccgggg      300

cccccctctg agaaggcctg gcagcctggc tggacagtca atgtggaggg cagcggggag      360

ctgttccggt ggaatgtttc ggacctaggt ggcctgggct gtggcctgaa gaacaggtcc      420

tcagagggcc ccagctcccc ttccgggaag ctcatgagcc ccaagctgta tgtgtgggcc      480

aaagaccgcc ctgagatctg ggagggagag cctccgtgtc tcccaccgag ggacagcctg      540

aaccagagcc tcagccagga cctcaccatg gcccctggct ccacactctg gctgtcctgt      600

ggggtacccc ctgactctgt gtccaggggc cccctctcct ggacccatgt gcaccccaag      660

gggcctaagt cattgctgag cctagagctg aaggacgatc gcccggccag agatatgtgg      720

gtaatggaga cgggtctgtt gttgccccgg gccacagctc aagacgctgg aaagtattat      780

tgtcaccgtg gcaacctgac catgtcattc cacctggaga tcactgctcg gccaggagga      840

ggtgggtctg gaggtggagg atctggtgga ggtgggtctg gaggaggtgg gtctcaggtg      900

cagctggtgc agagcggcgc cgaggacaag aagcccggcg agagcgtgaa gatcagctgc      960

aaggccagcg gctacacctt caccaactac ggcatgaact gggtgaggca ggcccccggc     1020

cagggcctga agtggatggg ctggatcaac acctacaccg gcgagagcac ctacgccgac     1080

gacttcaagg gcaggttcgc cttcagcctg gacaccagcg ccagcaccgc ctacctgcag     1140

ctgagcagcc tgaggggcga ggacaccgcc gtgtacttct gcgccaggtt cgccatcaag     1200

ggcgactact ggggccaggg caccaccgtg accgtgagca gcgccagcac cggcggcggc     1260

ggcagcggcg gcggcggcag cggcggcggc ggcagcggcg gcggcggcag cgacatcgtg     1320

atgacccaga gccccctgag cctggaggtg agccccggcg agcccgccag catcagctgc     1380

aggagcacca agagcctgct gcacagcgac ggcatcacct acctgtactg gtacctgcag     1440

aagcccggcc agagccccca gctgctgatc taccagctga gcaacctggc cagcggcgtg     1500

cccgacaggt tcagcagcag cggcagcggc accgacttca ccctgaagat cagcagggtg     1560

gaggccgagg acgagggcac ctactactgc gcccagaacc tggagatccc caggaccttc     1620

ggccagggca ccaagctgga gatcaagagg acccatcatc accatcacca t              1671


<210> 5
<211> 552
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 5
Met Pro Pro Pro Arg Leu Leu Phe Phe Leu Leu Phe Leu Thr Pro Met 
1               5                   10                  15      


Glu Val Arg Pro Glu Glu Pro Leu Val Val Lys Val Glu Glu Gly Asp 
            20                  25                  30          


Asn Ala Val Leu Gln Cys Leu Lys Gly Thr Ser Asp Gly Pro Thr Gln 
        35                  40                  45              


Gln Leu Thr Trp Ser Arg Glu Ser Pro Leu Lys Pro Phe Leu Lys Leu 
    50                  55                  60                  


Ser Leu Gly Leu Pro Gly Leu Gly Ile His Met Arg Pro Leu Ala Ile 
65                  70                  75                  80  


Trp Leu Phe Ile Phe Asn Val Ser Gln Gln Met Gly Gly Phe Tyr Leu 
                85                  90                  95      


Cys Gln Pro Gly Pro Pro Ser Glu Lys Ala Trp Gln Pro Gly Trp Thr 
            100                 105                 110         


Val Asn Val Glu Gly Ser Gly Glu Leu Phe Arg Trp Asn Val Ser Asp 
        115                 120                 125             


Leu Gly Gly Leu Gly Cys Gly Leu Lys Asn Arg Ser Ser Glu Gly Pro 
    130                 135                 140                 


Ser Ser Pro Ser Gly Lys Leu Met Ser Pro Lys Leu Tyr Val Trp Ala 
145                 150                 155                 160 


Lys Asp Arg Pro Glu Ile Trp Glu Gly Glu Pro Pro Cys Leu Pro Pro 
                165                 170                 175     


Arg Asp Ser Leu Asn Gln Ser Leu Ser Gln Asp Leu Thr Met Ala Pro 
            180                 185                 190         


Gly Ser Thr Leu Trp Leu Ser Cys Gly Val Pro Pro Asp Ser Val Ser 
        195                 200                 205             


Arg Gly Pro Leu Ser Trp Thr His Val His Pro Lys Gly Pro Lys Ser 
    210                 215                 220                 


Leu Leu Ser Leu Glu Leu Lys Asp Asp Arg Pro Ala Arg Asp Met Trp 
225                 230                 235                 240 


Val Met Glu Thr Gly Leu Leu Leu Pro Arg Ala Thr Ala Gln Asp Ala 
                245                 250                 255     


Gly Lys Tyr Tyr Cys His Arg Gly Asn Leu Thr Met Ser Phe His Leu 
            260                 265                 270         


Glu Ile Thr Ala Arg Pro Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        275                 280                 285             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Val Gln 
    290                 295                 300                 


Ser Gly Ala Glu Asp Val Lys Pro Asp Ala Ser Val Lys Leu Ser Cys 
305                 310                 315                 320 


Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr Tyr Met His Trp Val Arg 
                325                 330                 335     


Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Arg Val Asn Pro Asn 
            340                 345                 350         


Arg Arg Gly Thr Thr Tyr Asn Gln Lys Phe Glu Gly Arg Val Thr Met 
        355                 360                 365             


Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu 
    370                 375                 380                 


Arg Gly Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ala Asn Trp Leu 
385                 390                 395                 400 


Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr 
                405                 410                 415     


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
            420                 425                 430         


Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Glu 
        435                 440                 445             


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Ser Val Ser Ser Ser 
    450                 455                 460                 


Val Ser Ser Ile Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Lys Ser 
465                 470                 475                 480 


Pro Lys Leu Leu Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val Pro 
                485                 490                 495     


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
            500                 505                 510         


Ser Ser Leu Gln Ala Glu Asp Glu Gly Thr Tyr Tyr Cys Gln Val Tyr 
        515                 520                 525             


Ser Gly Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
    530                 535                 540                 


Arg Thr His His His His His His 
545                 550         


<210> 6
<211> 1656
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 6
atgccacctc ctcgcctcct cttcttcctc ctcttcctca cccccatgga agtcaggccc       60

gaggaacctc tagtggtgaa ggtggaagag ggagataacg ctgtgctgca gtgcctcaag      120

gggacctcag atggccccac tcagcagctg acctggtctc gggagtcccc gcttaaaccc      180

ttcttaaaac tcagcctggg gctgccaggc ctgggaatcc acatgaggcc cctggccatc      240

tggcttttca tcttcaacgt ctctcaacag atggggggct tctacctgtg ccagccgggg      300

cccccctctg agaaggcctg gcagcctggc tggacagtca atgtggaggg cagcggggag      360

ctgttccggt ggaatgtttc ggacctaggt ggcctgggct gtggcctgaa gaacaggtcc      420

tcagagggcc ccagctcccc ttccgggaag ctcatgagcc ccaagctgta tgtgtgggcc      480

aaagaccgcc ctgagatctg ggagggagag cctccgtgtc tcccaccgag ggacagcctg      540

aaccagagcc tcagccagga cctcaccatg gcccctggct ccacactctg gctgtcctgt      600

ggggtacccc ctgactctgt gtccaggggc cccctctcct ggacccatgt gcaccccaag      660

gggcctaagt cattgctgag cctagagctg aaggacgatc gcccggccag agatatgtgg      720

gtaatggaga cgggtctgtt gttgccccgg gccacagctc aagacgctgg aaagtattat      780

tgtcaccgtg gcaacctgac catgtcattc cacctggaga tcactgctcg gccaggagga      840

ggtgggtctg gaggtggagg atctggtgga ggtgggtctg gaggaggtgg gtctcaggtt      900

cagctggtgc agtctggtgc tgaggatgtg aagcctgatg cctcagtgaa gctctcctgc      960

aaggcttctg gttacacatt cactgactac tacatgcact gggtgcgtca ggcccctggt     1020

caaggtcttg agtggatggg tcgtgttaat cctaaccgga ggggtactac ctacaaccag     1080

aaattcgagg gccgtgtcac catgaccaca gacacatcca cgagcacagc ctacatgcag     1140

ctgagtagcc tgcgtggtga agacacggcc gtgtattact gtgcgcgtgc gaactggctt     1200

gactactggg gccagggcac caccgtcacc gtctcctccg cctccaccgg gggaggtggg     1260

tctggaggtg gaggatctgg tggaggtggg tctggtggag gtgggtctga catccagatg     1320

acccagtctc catcctccct ggaggcatct gtaggagaca gagtcaccat cacttgcagt     1380

gtcagctcaa gtgtatcctc catttacttg cactggtatc agcagaaacc agggaaaagc     1440

cctaagctcc tgatctatag cacatccaac ttggcttctg gagtcccaga taggttcagt     1500

ggcagtggat ctgggacaga tttcactctc accatcagca gtctgcaagc cgaagatgag     1560

ggcacttact actgtcaagt ctacagtggt tacccgctca cgttcggcgg agggaccaag     1620

ctggagatca aacgaactca tcatcaccat caccat                               1656


<210> 7
<211> 555
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 7
Met Pro Pro Pro Arg Leu Leu Phe Phe Leu Leu Phe Leu Thr Pro Met 
1               5                   10                  15      


Glu Val Arg Pro Glu Glu Pro Leu Val Val Lys Val Glu Glu Gly Asp 
            20                  25                  30          


Asn Ala Val Leu Gln Cys Leu Lys Gly Thr Ser Asp Gly Pro Thr Gln 
        35                  40                  45              


Gln Leu Thr Trp Ser Arg Glu Ser Pro Leu Lys Pro Phe Leu Lys Leu 
    50                  55                  60                  


Ser Leu Gly Leu Pro Gly Leu Gly Ile His Met Arg Pro Leu Ala Ile 
65                  70                  75                  80  


Trp Leu Phe Ile Phe Asn Val Ser Gln Gln Met Gly Gly Phe Tyr Leu 
                85                  90                  95      


Cys Gln Pro Gly Pro Pro Ser Glu Lys Ala Trp Gln Pro Gly Trp Thr 
            100                 105                 110         


Val Asn Val Glu Gly Ser Gly Glu Leu Phe Arg Trp Asn Val Ser Asp 
        115                 120                 125             


Leu Gly Gly Leu Gly Cys Gly Leu Lys Asn Arg Ser Ser Glu Gly Pro 
    130                 135                 140                 


Ser Ser Pro Ser Gly Lys Leu Met Ser Pro Lys Leu Tyr Val Trp Ala 
145                 150                 155                 160 


Lys Asp Arg Pro Glu Ile Trp Glu Gly Glu Pro Pro Cys Leu Pro Pro 
                165                 170                 175     


Arg Asp Ser Leu Asn Gln Ser Leu Ser Gln Asp Leu Thr Met Ala Pro 
            180                 185                 190         


Gly Ser Thr Leu Trp Leu Ser Cys Gly Val Pro Pro Asp Ser Val Ser 
        195                 200                 205             


Arg Gly Pro Leu Ser Trp Thr His Val His Pro Lys Gly Pro Lys Ser 
    210                 215                 220                 


Leu Leu Ser Leu Glu Leu Lys Asp Asp Arg Pro Ala Arg Asp Met Trp 
225                 230                 235                 240 


Val Met Glu Thr Gly Leu Leu Leu Pro Arg Ala Thr Ala Gln Asp Ala 
                245                 250                 255     


Gly Lys Tyr Tyr Cys His Arg Gly Asn Leu Thr Met Ser Phe His Leu 
            260                 265                 270         


Glu Ile Thr Ala Arg Pro Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        275                 280                 285             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Glu 
    290                 295                 300                 


Ser Gly Pro Gly Asp Val Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys 
305                 310                 315                 320 


Thr Val Ser Gly Gly Ser Val Ser Ser Gly Asp Tyr Tyr Trp Thr Trp 
                325                 330                 335     


Ile Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Ile Gly His Ile Tyr 
            340                 345                 350         


Tyr Ser Gly Asn Thr Asn Tyr Asn Pro Ser Leu Lys Ser Arg Leu Thr 
        355                 360                 365             


Ile Ser Ile Asp Thr Ser Lys Thr Thr Phe Ser Leu Gln Leu Ser Ser 
    370                 375                 380                 


Val Thr Gly Glu Asp Thr Ala Ile Tyr Tyr Cys Val Arg Asp Arg Val 
385                 390                 395                 400 


Thr Gly Ala Phe Asp Ile Trp Gly Gln Gly Thr Thr Val Thr Val Ser 
                405                 410                 415     


Ser Ala Ser Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            420                 425                 430         


Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 
        435                 440                 445             


Ser Ser Leu Glu Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln 
    450                 455                 460                 


Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro 
465                 470                 475                 480 


Gly Lys Ser Pro Lys Leu Leu Ile Tyr Asp Ala Ser Asn Leu Glu Thr 
                485                 490                 495     


Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
            500                 505                 510         


Phe Thr Ile Ser Ser Leu Gln Ala Glu Asp Glu Gly Thr Tyr Phe Cys 
        515                 520                 525             


Gln His Phe Asp His Leu Pro Leu Ala Phe Gly Gly Gly Thr Lys Leu 
    530                 535                 540                 


Glu Ile Lys Arg Thr His His His His His His 
545                 550                 555 


<210> 8
<211> 1665
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 8
atgccacctc ctcgcctcct cttcttcctc ctcttcctca cccccatgga agtcaggccc       60

gaggaacctc tagtggtgaa ggtggaagag ggagataacg ctgtgctgca gtgcctcaag      120

gggacctcag atggccccac tcagcagctg acctggtctc gggagtcccc gcttaaaccc      180

ttcttaaaac tcagcctggg gctgccaggc ctgggaatcc acatgaggcc cctggccatc      240

tggcttttca tcttcaacgt ctctcaacag atggggggct tctacctgtg ccagccgggg      300

cccccctctg agaaggcctg gcagcctggc tggacagtca atgtggaggg cagcggggag      360

ctgttccggt ggaatgtttc ggacctaggt ggcctgggct gtggcctgaa gaacaggtcc      420

tcagagggcc ccagctcccc ttccgggaag ctcatgagcc ccaagctgta tgtgtgggcc      480

aaagaccgcc ctgagatctg ggagggagag cctccgtgtc tcccaccgag ggacagcctg      540

aaccagagcc tcagccagga cctcaccatg gcccctggct ccacactctg gctgtcctgt      600

ggggtacccc ctgactctgt gtccaggggc cccctctcct ggacccatgt gcaccccaag      660

gggcctaagt cattgctgag cctagagctg aaggacgatc gcccggccag agatatgtgg      720

gtaatggaga cgggtctgtt gttgccccgg gccacagctc aagacgctgg aaagtattat      780

tgtcaccgtg gcaacctgac catgtcattc cacctggaga tcactgctcg gccaggagga      840

ggtgggtctg gaggtggagg atctggtgga ggtgggtctg gaggaggtgg gtctcaggtg      900

cagctgcagg agagcggccc cggcgacgtg aagcccagcg agaccctgag cctgacctgc      960

accgtgagcg gcggcagcgt gagcagcggc gactactact ggacctggat caggcagagc     1020

cccggcaagg gcctggagtg gatcggccac atctactaca gcggcaacac caactacaac     1080

cccagcctga agagcaggct gaccatcagc atcgacacca gcaagaccac cttcagcctg     1140

cagctgagca gcgtgaccgg cgaggacacc gccatctact actgcgtgag ggacagggtg     1200

accggcgcct tcgacatctg gggccagggc accaccgtga ccgtgagcag cgccagcacc     1260

ggcggcggcg gcagcggcgg cggcggcagc ggcggcggcg gcagcggcgg cggcggcagc     1320

gacatccaga tgacccagag ccccagcagc ctggaggcca gcgtgggcga cagggtgacc     1380

atcacctgcc aggccagcca ggacatcagc aactacctga actggtacca gcagaagccc     1440

ggcaagagcc ccaagctgct gatctacgac gccagcaacc tggagaccgg cgtgcccgac     1500

aggttcagcg gcagcggcag cggcaccgac ttcaccttca ccatcagcag cctgcaggcc     1560

gaggacgagg gcacctactt ctgccagcac ttcgaccacc tgcccctggc cttcggcggc     1620

ggcaccaagc tggagatcaa gaggacccat catcaccatc accat                     1665


