                         SEQUENCE LISTING

<110>  Galaxy Biotech, LLC
       Kim, Kyung Jin
       Park, Hangil
       Wang, Lihong
       Ding, Yi
       Zhang, April
       Vasquez, Maximiliano
 
<120>  HIGHLY POTENT ANTIBODIES BINDING TO DEATH RECEPTOR 4 AND DEATH 
       RECEPTOR 5

<130>  057763-482739

<140>  PCT/US2016/059517
<141>  2016-10-28

<150>  62/248,789
<151>  2015-10-30

<150>  62/248,782
<151>  2015-10-30

<160>  40    

<170>  PatentIn version 3.5

<210>  1
<211>  127
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<223>  Mature heavy chain variable region of 4H6 mAb

<400>  1

Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Tyr 
            20                  25                  30          


Gly Val His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Ala Val Gly Ser Thr Asn Tyr Asn Ser Ala Leu Met 
    50                  55                  60                  


Ser Arg Leu Ser Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Met Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Glu Gly Glu Phe Asp Tyr Tyr Gly Ser Ser Leu Leu Ser Tyr His 
            100                 105                 110         


Ser Met Asn Phe Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120                 125         


<210>  2
<211>  107
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<223>  Mature light chain variable region of 4H6 mAb

<400>  2

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Arg Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Phe 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  3
<211>  122
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<223>  Mature heavy chain variable region of 3H3 mAb

<400>  3

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Val Met His Trp Val Lys Gln Lys Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Ile Pro Tyr Asn Asp Gly Thr Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ser Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Ile Asn Tyr Asp Tyr Leu Tyr Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
        115                 120         


<210>  4
<211>  112
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<223>  Mature light chain variable region of 3H3 mAb

<400>  4

Asp Val Val Met Thr Gln Ile Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser 
                85                  90                  95      


Thr His Val Pro His Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  5
<211>  107
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<223>  mature light chain variable region mouse D114

<400>  5

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Ser Ala Ser Gln Asp Ile Thr Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Ile Lys Leu Leu Val 
        35                  40                  45              


Tyr Tyr Thr Ser Ser Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys His Gln Tyr Ser Lys Leu Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Ser Leu Glu Ile Lys 
            100                 105         


<210>  6
<211>  107
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized


<220>
<221>  MISC_FEATURE
<223>  Mature variable region of HuD114-L1 light chain

<400>  6

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Gln Asp Ile Thr Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Val 
        35                  40                  45              


Tyr Tyr Thr Ser Ser Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys His Gln Tyr Ser Lys Leu Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  7
<211>  107
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  human acceptor AIT38746  VK sequence

<400>  7

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Asn Leu Thr Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  8
<211>  117
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<223>  mature heavy chain variable region mouse D114

<400>  8

Gln Ile Gln Leu Gln Gln Ser Gly Pro Glu Leu Met Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Tyr Ile Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Trp Ile Tyr Pro Gly Ile Gly Asp Ile Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Arg Ala Thr Leu Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Asn Arg Leu Thr Ser Asp Asp Thr Gly Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Ser Gly Trp Ala Trp Phe Val Asp Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Ser Val Ser Ser 
        115         


<210>  9
<211>  117
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized


<220>
<221>  MISC_FEATURE
<223>  Mature variable region of HuD114-H1 heavy chain

<400>  9

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Tyr Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Trp Ile Tyr Pro Gly Ile Gly Asp Ile Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Thr Ala Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Gly Trp Ala Trp Phe Val Asp Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  10
<211>  117
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized


<220>
<221>  MISC_FEATURE
<223>  Mature variable region of HuD114-H2 heavy chain

<400>  10

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Tyr Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Trp Ile Tyr Pro Gly Ile Gly Asp Ile Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Arg Ala Thr Leu Thr Ala Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Gly Trp Ala Trp Phe Val Asp Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  11
<211>  118
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  human acceptor AAC18293 VH sequence

<400>  11

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Pro Asn Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Thr Ala Gly Ala Ala Tyr Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  12
<211>  111
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<223>  mature light chain variable region mouse G4.2

<400>  12

Asn Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Met Ser Cys Arg Ala Ser Glu Ser Val Asp Ile Tyr 
            20                  25                  30          


Gly Asn Ser Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Leu Ser Ser Asn Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Asp 
65                  70                  75                  80  


Pro Val Glu Ala Asp Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr 
                85                  90                  95      


Glu Asp Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Asp Leu Lys 
            100                 105                 110     


<210>  13
<211>  111
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized


<220>
<221>  MISC_FEATURE
<223>  mature variable region of HuG4.2-L1 light chain

<400>  13

Asp Ile Val Leu Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Arg Ala Ser Glu Ser Val Asp Ile Tyr 
            20                  25                  30          


Gly Asn Ser Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Leu Ser Ser Asn Leu Glu Ser Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln Ser Tyr 
                85                  90                  95      


Glu Asp Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110     


<210>  14
<211>  111
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized


<220>
<221>  MISC_FEATURE
<223>  mature variable region of HuG4.2-L2 light chain

<400>  14

Asn Ile Val Leu Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Arg Ala Ser Glu Ser Val Asp Ile Tyr 
            20                  25                  30          


Gly Asn Ser Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Leu Ser Ser Asn Leu Glu Ser Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln Ser Tyr 
                85                  90                  95      


Glu Asp Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110     


<210>  15
<211>  113
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  human acceptor AAQ02698 VK sequence

<400>  15

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Tyr Ser 
            20                  25                  30          


Ser Asn Asn Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Ser Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys 
    


<210>  16
<211>  121
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<223>  mature heavy chain variable region mouse G4.2

<400>  16

Asp Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Lys Leu Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Leu Pro Phe Asn Ser Tyr 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Leu Val 
        35                  40                  45              


Ala Ala Ile Asn Ser Asn Gly Gly Arg Ile His Tyr Pro Asp Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Lys Ser Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Leu Thr Tyr Tyr Gly Asn Pro Ala Trp Phe Ala Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ala 
        115                 120     


<210>  17
<211>  121
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized


<220>
<221>  MISC_FEATURE
<223>  mature variable region of HuG4.2-H1 heavy chain

<400>  17

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Pro Phe Asn Ser Tyr 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ala Ile Asn Ser Asn Gly Gly Arg Ile His Tyr Pro Asp Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Leu Thr Tyr Tyr Gly Asn Pro Ala Trp Phe Ala Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  18
<211>  121
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized


<220>
<221>  MISC_FEATURE
<223>  mature variable region of HuG4.2-H2 heavy chain

<400>  18

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Pro Phe Asn Ser Tyr 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Leu Val 
        35                  40                  45              


Ala Ala Ile Asn Ser Asn Gly Gly Arg Ile His Tyr Pro Asp Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Leu Thr Tyr Tyr Gly Asn Pro Ala Trp Phe Ala Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  19
<211>  116
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  human acceptor AAC50998 VH sequence

<400>  19

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asn Ile Lys Gln Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ser Ser Asp Met Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  20
<211>  11
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<223>  CDR-L1 of D114

<400>  20

Ser Ala Ser Gln Asp Ile Thr Asn Tyr Leu Asn 
1               5                   10      


<210>  21
<211>  7
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<223>  CDR-L2 of D114

<400>  21

Tyr Thr Ser Ser Leu His Ser 
1               5           


<210>  22
<211>  9
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<223>  CDR-L3 of D114

<400>  22

His Gln Tyr Ser Lys Leu Pro Trp Thr 
1               5                   


<210>  23
<211>  5
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<223>  CDR-H1 of D114

<400>  23

Asn Tyr Tyr Ile Asn 
1               5   


<210>  24
<211>  17
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<223>  CDR-H2 of D114

<400>  24

Trp Ile Tyr Pro Gly Ile Gly Asp Ile Lys Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  25
<211>  8
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<223>  CDR-H3 of D114

<400>  25

Ser Gly Trp Ala Trp Phe Val Asp 
1               5               


<210>  26
<211>  15
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<223>  CDR-L1 of G4.2

<400>  26

Arg Ala Ser Glu Ser Val Asp Ile Tyr Gly Asn Ser Phe Met His 
1               5                   10                  15  


<210>  27
<211>  7
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<223>  CDR-L2 of G4.2

<400>  27

Leu Ser Ser Asn Leu Glu Ser 
1               5           


<210>  28
<211>  9
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<223>  CDR-L3 of G4.2

<400>  28

Gln Gln Ser Tyr Glu Asp Pro Leu Thr 
1               5                   


<210>  29
<211>  5
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<223>  CDR-H1 of G4.2

<400>  29

Ser Tyr Tyr Met Ser 
1               5   


<210>  30
<211>  17
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<223>  CDR-H2 of G4.2

<400>  30

Ala Ile Asn Ser Asn Gly Gly Arg Ile His Tyr Pro Asp Thr Val Lys 
1               5                   10                  15      


Gly 
    


<210>  31
<211>  12
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<223>  CDR-H3 of G4.2

<400>  31

Leu Thr Tyr Tyr Gly Asn Pro Ala Trp Phe Ala Tyr 
1               5                   10          


<210>  32
<211>  604
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized


<220>
<221>  MISC_FEATURE
<223>  complete heavy chain of B-4H6/3H3-hFc** bispecific antibody 
       including signal peptide

<400>  32

Met Glu Phe Gly Leu Ser Trp Val Phe Leu Val Ala Leu Leu Arg Gly 
1               5                   10                  15      


Val Gln Cys Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Ala 
            20                  25                  30          


Pro Ser Gln Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu 
        35                  40                  45              


Thr Ser Tyr Gly Val His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Leu Gly Val Ile Trp Ala Val Gly Ser Thr Asn Tyr Asn Ser 
65                  70                  75                  80  


Ala Leu Met Ser Arg Leu Ser Ile Ser Lys Asp Asn Ser Lys Ser Gln 
                85                  90                  95      


Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Met Tyr 
            100                 105                 110         


Tyr Cys Ala Arg Glu Gly Glu Phe Asp Tyr Tyr Gly Ser Ser Leu Leu 
        115                 120                 125             


Ser Tyr His Ser Met Asn Phe Trp Gly Gln Gly Thr Ser Val Thr Val 
    130                 135                 140                 


Ser Ser Ala Ser Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
145                 150                 155                 160 


Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu 
                165                 170                 175     


Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln 
            180                 185                 190         


Asp Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Arg Lys Pro Asp Gly Thr 
        195                 200                 205             


Val Lys Leu Leu Ile Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro 
    210                 215                 220                 


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile 
225                 230                 235                 240 


Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly 
                245                 250                 255     


Asn Thr Leu Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            260                 265                 270         


Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser 
        275                 280                 285             


Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys 
    290                 295                 300                 


Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
305                 310                 315                 320 


Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
                325                 330                 335     


Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr 
            340                 345                 350         


Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val 
        355                 360                 365             


Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro 
    370                 375                 380                 


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
385                 390                 395                 400 


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
                405                 410                 415     


Thr Cys Val Val Val Asp Val Glu His Glu Asp Pro Glu Val Lys Phe 
            420                 425                 430         


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
        435                 440                 445             


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
    450                 455                 460                 


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
465                 470                 475                 480 


Ser Asn Lys Ala Phe Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
                485                 490                 495     


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
            500                 505                 510         


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
        515                 520                 525             


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
    530                 535                 540                 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
545                 550                 555                 560 


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
                565                 570                 575     


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
            580                 585                 590         


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        595                 600                 


<210>  33
<211>  379
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized


<220>
<221>  MISC_FEATURE
<223>  complete light chain of B-4H6/3H3-hFc** bispecific antibody 
       including signal peptide

<400>  33

Met Glu Trp Ser Trp Ile Phe Leu Phe Leu Leu Ser Gly Thr Ala Gly 
1               5                   10                  15      


Val His Ser Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Ser Tyr Val Met His Trp Val Lys Gln Lys Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Tyr Ile Ile Pro Tyr Asn Asp Gly Thr Lys Tyr Asn 
65                  70                  75                  80  


Glu Lys Phe Lys Gly Lys Ala Thr Leu Thr Ser Asp Lys Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Ser Arg Leu Thr Ser Glu Asp Ser Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Gly Gly Ile Asn Tyr Asp Tyr Leu Tyr Tyr Phe 
        115                 120                 125             


Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Ala Ser Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
145                 150                 155                 160 


Asp Val Val Met Thr Gln Ile Pro Leu Ser Leu Pro Val Ser Leu Gly 
                165                 170                 175     


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            180                 185                 190         


Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        195                 200                 205             


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    210                 215                 220                 


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
225                 230                 235                 240 


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser 
                245                 250                 255     


Thr His Val Pro His Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            260                 265                 270         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        275                 280                 285             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    290                 295                 300                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
305                 310                 315                 320 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                325                 330                 335     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            340                 345                 350         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        355                 360                 365             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    370                 375                 


<210>  34
<211>  585
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized


<220>
<221>  MISC_FEATURE
<223>  mature heavy chain of B-4H6/3H3-hFc** bispecific antibody

<400>  34

Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Tyr 
            20                  25                  30          


Gly Val His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Ala Val Gly Ser Thr Asn Tyr Asn Ser Ala Leu Met 
    50                  55                  60                  


Ser Arg Leu Ser Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Met Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Glu Gly Glu Phe Asp Tyr Tyr Gly Ser Ser Leu Leu Ser Tyr His 
            100                 105                 110         


Ser Met Asn Phe Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Ala 
        115                 120                 125             


Ser Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser 
145                 150                 155                 160 


Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser 
                165                 170                 175     


Asn Tyr Leu Asn Trp Tyr Gln Arg Lys Pro Asp Gly Thr Val Lys Leu 
            180                 185                 190         


Leu Ile Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe 
        195                 200                 205             


Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu 
    210                 215                 220                 


Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu 
225                 230                 235                 240 


Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys Ser Ser Ala 
                245                 250                 255     


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
            260                 265                 270         


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
        275                 280                 285             


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
    290                 295                 300                 


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
305                 310                 315                 320 


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
                325                 330                 335     


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg 
            340                 345                 350         


Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
        355                 360                 365             


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
    370                 375                 380                 


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
385                 390                 395                 400 


Val Val Asp Val Glu His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
                405                 410                 415     


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
            420                 425                 430         


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
        435                 440                 445             


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
    450                 455                 460                 


Ala Phe Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
465                 470                 475                 480 


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
                485                 490                 495     


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
            500                 505                 510         


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
        515                 520                 525             


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
    530                 535                 540                 


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
545                 550                 555                 560 


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
                565                 570                 575     


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            580                 585 


<210>  35
<211>  360
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized


<220>
<221>  MISC_FEATURE
<223>  mature light chain of B-4H6/3H3-hFc** bispecific antibody

<400>  35

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Val Met His Trp Val Lys Gln Lys Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Ile Pro Tyr Asn Asp Gly Thr Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ser Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Ile Asn Tyr Asp Tyr Leu Tyr Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Ala Ser Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Val Val 
    130                 135                 140                 


Met Thr Gln Ile Pro Leu Ser Leu Pro Val Ser Leu Gly Asp Gln Ala 
145                 150                 155                 160 


Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser Asn Gly Asn 
                165                 170                 175     


Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Lys Leu 
            180                 185                 190         


Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro Asp Arg Phe 
        195                 200                 205             


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg Val 
    210                 215                 220                 


Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser Thr His Val 
225                 230                 235                 240 


Pro His Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val 
                245                 250                 255     


Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys 
            260                 265                 270         


Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg 
        275                 280                 285             


Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn 
    290                 295                 300                 


Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser 
305                 310                 315                 320 


Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys 
                325                 330                 335     


Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr 
            340                 345                 350         


Lys Ser Phe Asn Arg Gly Glu Cys 
        355                 360 


<210>  36
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized


<220>
<221>  MISC_FEATURE
<223>  linker

<400>  36

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Ser 
    


<210>  37
<211>  19
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized


<220>
<221>  MISC_FEATURE
<223>  linker

<400>  37

Ala Ser Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
1               5                   10                  15      


Gly Gly Ser 
            


<210>  38
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized


<220>
<221>  MISC_FEATURE
<223>  linker

<400>  38

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
1               5                   10              


<210>  39
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized


<220>
<221>  MISC_FEATURE
<223>  linker

<400>  39

Arg Thr Val Ala Ala Pro Ser Val Ile Phe Ile Pro Pro 
1               5                   10              


<210>  40
<211>  19
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized


<220>
<221>  MISC_FEATURE
<223>  linker

<400>  40

Ala Ser Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
1               5                   10                  15      


Gly Gly Ser 
            


