                         SEQUENCE LISTING

<110>  The United States of America, as represented by the 
       Secretary, Department of Health and Human Services
       Aleta Biotherapeutics, Inc.
 
<120>  TARGETED CANCER THERAPY

<130>  A0915.70014WO00

<140>  Not Yet Assigned
<141>  2016-10-28

<150>  US 62/249,033
<151>  2015-10-30

<160>  21    

<170>  PatentIn version 3.5

<210>  1
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  1

Asp Tyr Lys Asp Asp Asp Asp Lys 
1               5               


<210>  2
<211>  242
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  2

Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly Asp Ser Val Ser Ser Asn 
            20                  25                  30          


Ser Ala Ala Trp Asn Trp Ile Arg Gln Ser Pro Ser Arg Gly Leu Glu 
        35                  40                  45              


Trp Leu Gly Arg Thr Tyr Tyr Arg Ser Lys Trp Tyr Asn Asp Tyr Ala 
    50                  55                  60                  


Val Ser Val Lys Ser Arg Ile Thr Ile Asp Pro Asp Thr Ser Lys Asn 
65                  70                  75                  80  


Gln Phe Ser Leu Gln Leu Asn Ser Val Thr Pro Glu Asp Thr Ala Met 
                85                  90                  95      


Tyr Tyr Cys Ala Arg Glu Gly Asp Asp Ala Phe Asp Ile Trp Gly Gln 
            100                 105                 110         


Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Ser Gly 
        115                 120                 125             


Ala Ser Ser Gly Gly Gly Ser Ser Tyr Val Leu Thr Gln Leu Pro Ser 
    130                 135                 140                 


Val Ser Val Ser Pro Gly Gln Thr Ala Arg Ile Thr Cys Gly Gly Asn 
145                 150                 155                 160 


Asn Ile Gly Ser Lys Ser Val His Trp Tyr Gln Gln Lys Pro Gly Gln 
                165                 170                 175     


Ala Pro Val Leu Val Val Tyr Asp Asp Ser Asp Arg Pro Ser Gly Ile 
            180                 185                 190         


Pro Glu Arg Phe Ser Gly Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr 
        195                 200                 205             


Ile Ser Gly Thr Gln Ala Met Asp Glu Ala Asp Tyr Tyr Cys Gln Ala 
    210                 215                 220                 


Trp Asp Ser Gly Thr Ala Val Phe Gly Gly Gly Thr Lys Val Thr Val 
225                 230                 235                 240 


Leu Gly 
        


<210>  3
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  3

Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly Asp Ser Val Ser Ser Asn 
            20                  25                  30          


Ser Ala Ala Trp Asn Trp Ile Arg Gln Ser Pro Ser Arg Gly Leu Glu 
        35                  40                  45              


Trp Leu Gly Arg Thr Tyr Tyr Arg Ser Lys Trp Tyr Asn Asp Tyr Ala 
    50                  55                  60                  


Val Ser Val Lys Ser Arg Ile Thr Ile Asp Pro Asp Thr Ser Lys Asn 
65                  70                  75                  80  


Gln Phe Ser Leu Gln Leu Asn Ser Val Thr Pro Glu Asp Thr Ala Met 
                85                  90                  95      


Tyr Tyr Cys Ala Arg Glu Gly Asp Asp Ala Phe Asp Ile Trp Gly Gln 
            100                 105                 110         


Gly Thr Met Val Thr Val Ser Ser 
        115                 120 


<210>  4
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  4

Gly Asp Ser Val Ser Ser Asn Ser Ala Ala 
1               5                   10  


<210>  5
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  5

Thr Tyr Tyr Arg Ser Lys Trp Tyr Asn 
1               5                   


<210>  6
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  6

Ala Arg Glu Gly Asp Asp Ala Phe Asp 
1               5                   


<210>  7
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  7

Ser Tyr Val Leu Thr Gln Leu Pro Ser Val Ser Val Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly Ser Lys Ser Val 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Val Tyr 
        35                  40                  45              


Asp Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Met 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Ala Trp Asp Ser Gly Thr Ala Val 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Thr Val Leu Gly 
            100                 105         


<210>  8
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  8

Asn Ile Gly Ser Lys Ser 
1               5       


<210>  9
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  9

Asp Asp Ser 
1           


<210>  10
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  10

Gln Ala Trp Asp Ser Gly Thr Ala Val 
1               5                   


<210>  11
<211>  726
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  11
caggtacagc tgcagcagtc aggtccagga ctggtgaagc cctcgcagac cctctcactc       60

acctgtgcca tctccgggga cagtgtctct agcaacagtg ctgcttggaa ctggatcagg      120

cagtccccat cgagaggcct tgagtggctg ggaaggacat actacaggtc caagtggtat      180

aatgattatg cagtatctgt gaaaagtcga ataaccatcg acccagacac atccaagaac      240

cagttctccc tgcagctgaa ctctgtgact cccgaggata cggctatgta ttactgtgca      300

agagagggag atgatgcttt tgatatctgg ggccaaggga caatggtcac cgtctcctca      360

ggaggtggcg ggtctggtag tggcgctagc agtggtggcg gatcctccta tgtgctgact      420

cagctaccct cggtgtcagt gtccccagga cagacggcca ggattacctg tgggggaaac      480

aacattggaa gtaaaagtgt gcactggtac cagcagaagc caggccaggc ccctgtgctg      540

gtcgtctatg atgatagcga ccggccctca gggatccctg agcgattctc tggctccaac      600

tctgggaaca cagccactct gaccatcagc gggacccagg ctatggatga ggctgactat      660

tactgtcagg cgtgggacag cggcactgcg gtattcggcg gagggaccaa ggtcaccgtc      720

ctaggt                                                                 726


<210>  12
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  12

Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly Asp Ser Val Ser Ser Tyr 
            20                  25                  30          


Asn Ala Ala Trp Thr Trp Ile Arg Gln Ser Pro Ser Arg Gly Leu Glu 
        35                  40                  45              


Trp Leu Gly Arg Thr Tyr Tyr Gly Ser Lys Trp Tyr Thr Asp Tyr Ala 
    50                  55                  60                  


Val Ser Val Lys Ser Arg Ile Thr Ile Asn Pro Asp Thr Ser Lys Asn 
65                  70                  75                  80  


Gln Phe Ser Leu Gln Leu Asn Ser Val Thr Pro Glu Asp Thr Ala Val 
                85                  90                  95      


Tyr Tyr Cys Ala Arg Glu Ser Glu Leu Arg Ala Asp Ala Phe Asp Ile 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Ser Gly Ala Ser Gly Gly Gly Gly Ser Ser Ser Glu Leu Thr Gln 
    130                 135                 140                 


Asp Pro Ala Val Ser Val Ala Leu Gly Gln Thr Val Arg Ile Thr Cys 
145                 150                 155                 160 


Gln Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Gln Ala Pro Val Leu Val Ile Tyr Gly Lys Asn Asn Arg Pro 
            180                 185                 190         


Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Thr Thr Ala 
        195                 200                 205             


Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu Asp Glu Ala Asp Tyr Tyr 
    210                 215                 220                 


Cys Asn Ser Arg Asp Ser Ser Gly Asn His Leu Val Phe Gly Gly Gly 
225                 230                 235                 240 


Thr Lys Val Thr Val Leu Gly 
                245         


<210>  13
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  13

Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly Asp Ser Val Ser Ser Tyr 
            20                  25                  30          


Asn Ala Ala Trp Thr Trp Ile Arg Gln Ser Pro Ser Arg Gly Leu Glu 
        35                  40                  45              


Trp Leu Gly Arg Thr Tyr Tyr Gly Ser Lys Trp Tyr Thr Asp Tyr Ala 
    50                  55                  60                  


Val Ser Val Lys Ser Arg Ile Thr Ile Asn Pro Asp Thr Ser Lys Asn 
65                  70                  75                  80  


Gln Phe Ser Leu Gln Leu Asn Ser Val Thr Pro Glu Asp Thr Ala Val 
                85                  90                  95      


Tyr Tyr Cys Ala Arg Glu Ser Glu Leu Arg Ala Asp Ala Phe Asp Ile 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  14
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  14

Gly Asp Ser Val Ser Ser Tyr Asn Ala Ala 
1               5                   10  


<210>  15
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  15

Thr Tyr Tyr Gly Ser Lys Trp Tyr Thr 
1               5                   


<210>  16
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  16

Ala Arg Glu Ser Glu Leu Arg Ala Asp Ala Phe Asp Ile 
1               5                   10              


<210>  17
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  17

Ser Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln 
1               5                   10                  15      


Thr Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg Ser Tyr Tyr Ala 
            20                  25                  30          


Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Gly Lys Asn Asn Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  


Ser Ser Gly Thr Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His 
                85                  90                  95      


Leu Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu Gly 
            100                 105                 


<210>  18
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  18

Ser Leu Arg Ser Tyr Tyr 
1               5       


<210>  19
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  19

Gly Lys Asn 
1           


<210>  20
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  20

Asn Ser Arg Asp Ser Ser Gly Asn His Leu Val 
1               5                   10      


<210>  21
<211>  741
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  21
caggtacagc tgcagcagtc aggtccagga ctggtgaagc cctcgcagac cctctcactc       60

acctgtgcca tctccgggga cagtgtctct agctacaatg ctgcttggac ctggatcagg      120

cagtccccat cgagaggcct tgagtggctg ggaaggacat actacgggtc caagtggtat      180

actgattatg cagtatctgt gaaaagtcga ataaccatca acccagacac atccaagaac      240

cagttctccc tgcagctgaa ctctgtgact cccgaggaca cggctgtgta ttactgtgca      300

agagaatcag agctacgggc tgatgctttt gatatctggg gccaagggac cacggtcacc      360

gtctcctcag gaggtggcgg gtctggtagt ggcgctagcg gtggtggcgg atcctcttct      420

gagctgactc aggaccctgc tgtgtctgtg gccttgggac agacagtcag gatcacatgc      480

caaggagaca gcctcagaag ctattatgca agctggtacc agcagaagcc aggacaggcc      540

cctgtacttg tcatctatgg taaaaacaac cggccctcag ggatcccaga ccgattctct      600

ggctccagct caggaaccac agcttccttg accatcactg gggctcaggc ggaagatgag      660

gctgactatt actgtaactc ccgggacagc agtggtaacc atctggtatt cggcggaggg      720

accaaggtca ccgtcctagg t                                                741


