                         SEQUENCE LISTING

<110>  INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION
       ASHKAR, TAREK M
       MICANOVIC, RADMILA
 
<120>  MODIFIED TAMM-HORSFALL PROTEIN AND RELATED COMPOSITIONS AND 
       METHODS

<130>  IURTC-2016-026-02-WO-E

<150>  US 62/248,809
<151>  2015-10-30

<160>  7     

<170>  PatentIn version 3.5

<210>  1
<211>  640
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Gly Gln Pro Ser Leu Thr Trp Met Leu Met Val Val Val Ala Ser 
1               5                   10                  15      


Trp Phe Ile Thr Thr Ala Ala Thr Asp Thr Ser Glu Ala Arg Trp Cys 
            20                  25                  30          


Ser Glu Cys His Ser Asn Ala Thr Cys Thr Glu Asp Glu Ala Val Thr 
        35                  40                  45              


Thr Cys Thr Cys Gln Glu Gly Phe Thr Gly Asp Gly Leu Thr Cys Val 
    50                  55                  60                  


Asp Leu Asp Glu Cys Ala Ile Pro Gly Ala His Asn Cys Ser Ala Asn 
65                  70                  75                  80  


Ser Ser Cys Val Asn Thr Pro Gly Ser Phe Ser Cys Val Cys Pro Glu 
                85                  90                  95      


Gly Phe Arg Leu Ser Pro Gly Leu Gly Cys Thr Asp Val Asp Glu Cys 
            100                 105                 110         


Ala Glu Pro Gly Leu Ser His Cys His Ala Leu Ala Thr Cys Val Asn 
        115                 120                 125             


Val Val Gly Ser Tyr Leu Cys Val Cys Pro Ala Gly Tyr Arg Gly Asp 
    130                 135                 140                 


Gly Trp His Cys Glu Cys Ser Pro Gly Ser Cys Gly Pro Gly Leu Asp 
145                 150                 155                 160 


Cys Val Pro Glu Gly Asp Ala Leu Val Cys Ala Asp Pro Cys Gln Ala 
                165                 170                 175     


His Arg Thr Leu Asp Glu Tyr Trp Arg Ser Thr Glu Tyr Gly Glu Gly 
            180                 185                 190         


Tyr Ala Cys Asp Thr Asp Leu Arg Gly Trp Tyr Arg Phe Val Gly Gln 
        195                 200                 205             


Gly Gly Ala Arg Met Ala Glu Thr Cys Val Pro Val Leu Arg Cys Asn 
    210                 215                 220                 


Thr Ala Ala Pro Met Trp Leu Asn Gly Thr His Pro Ser Ser Asp Glu 
225                 230                 235                 240 


Gly Ile Val Ser Arg Lys Ala Cys Ala His Trp Ser Gly His Cys Cys 
                245                 250                 255     


Leu Trp Asp Ala Ser Val Gln Val Lys Ala Cys Ala Gly Gly Tyr Tyr 
            260                 265                 270         


Val Tyr Asn Leu Thr Ala Pro Pro Glu Cys His Leu Ala Tyr Cys Thr 
        275                 280                 285             


Asp Pro Ser Ser Val Glu Gly Thr Cys Glu Glu Cys Ser Ile Asp Glu 
    290                 295                 300                 


Asp Cys Lys Ser Asn Asn Gly Arg Trp His Cys Gln Cys Lys Gln Asp 
305                 310                 315                 320 


Phe Asn Ile Thr Asp Ile Ser Leu Leu Glu His Arg Leu Glu Cys Gly 
                325                 330                 335     


Ala Asn Asp Met Lys Val Ser Leu Gly Lys Cys Gln Leu Lys Ser Leu 
            340                 345                 350         


Gly Phe Asp Lys Val Phe Met Tyr Leu Ser Asp Ser Arg Cys Ser Gly 
        355                 360                 365             


Phe Asn Asp Arg Asp Asn Arg Asp Trp Val Ser Val Val Thr Pro Ala 
    370                 375                 380                 


Arg Asp Gly Pro Cys Gly Thr Val Leu Thr Arg Asn Glu Thr His Ala 
385                 390                 395                 400 


Thr Tyr Ser Asn Thr Leu Tyr Leu Ala Asp Glu Ile Ile Ile Arg Asp 
                405                 410                 415     


Leu Asn Ile Lys Ile Asn Phe Ala Cys Ser Tyr Pro Leu Asp Met Lys 
            420                 425                 430         


Val Ser Leu Lys Thr Ala Leu Gln Pro Met Val Ser Ala Leu Asn Ile 
        435                 440                 445             


Arg Val Gly Gly Thr Gly Met Phe Thr Val Arg Met Ala Leu Phe Gln 
    450                 455                 460                 


Thr Pro Ser Tyr Thr Gln Pro Tyr Gln Gly Ser Ser Val Thr Leu Ser 
465                 470                 475                 480 


Thr Glu Ala Phe Leu Tyr Val Gly Thr Met Leu Asp Gly Gly Asp Leu 
                485                 490                 495     


Ser Arg Phe Ala Leu Leu Met Thr Asn Cys Tyr Ala Thr Pro Ser Ser 
            500                 505                 510         


Asn Ala Thr Asp Pro Leu Lys Tyr Phe Ile Ile Gln Asp Arg Cys Pro 
        515                 520                 525             


His Thr Arg Asp Ser Thr Ile Gln Val Val Glu Asn Gly Glu Ser Ser 
    530                 535                 540                 


Gln Gly Arg Phe Ser Val Gln Met Phe Arg Phe Ala Gly Asn Tyr Asp 
545                 550                 555                 560 


Leu Val Tyr Leu His Cys Glu Val Tyr Leu Cys Asp Thr Met Asn Glu 
                565                 570                 575     


Lys Cys Lys Pro Thr Cys Ser Gly Thr Arg Phe Arg Ser Gly Ser Val 
            580                 585                 590         


Ile Asp Gln Ser Arg Val Leu Asn Leu Gly Pro Ile Thr Arg Lys Gly 
        595                 600                 605             


Val Gln Ala Thr Val Ser Arg Ala Phe Ser Ser Leu Gly Leu Leu Lys 
    610                 615                 620                 


Val Trp Leu Pro Leu Leu Leu Ser Ala Thr Leu Thr Leu Thr Phe Gln 
625                 630                 635                 640 


<210>  2
<211>  313
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2

Asp Thr Ser Glu Ala Arg Trp Cys Ser Glu Cys His Ser Asn Ala Thr 
1               5                   10                  15      


Cys Thr Glu Asp Glu Ala Val Thr Thr Cys Thr Cys Gln Glu Gly Phe 
            20                  25                  30          


Thr Gly Asp Gly Leu Thr Cys Val Asp Leu Asp Glu Cys Ala Ile Pro 
        35                  40                  45              


Gly Ala His Asn Cys Ser Ala Asn Ser Ser Cys Val Asn Thr Pro Gly 
    50                  55                  60                  


Ser Phe Ser Cys Val Cys Pro Glu Gly Phe Arg Leu Ser Pro Gly Leu 
65                  70                  75                  80  


Gly Cys Thr Asp Val Asp Glu Cys Ala Glu Pro Gly Leu Ser His Cys 
                85                  90                  95      


His Ala Leu Ala Thr Cys Val Asn Val Val Gly Ser Tyr Leu Cys Val 
            100                 105                 110         


Cys Pro Ala Gly Tyr Arg Gly Asp Gly Trp His Cys Glu Cys Ser Pro 
        115                 120                 125             


Gly Ser Cys Gly Pro Gly Leu Asp Cys Val Pro Glu Gly Asp Ala Leu 
    130                 135                 140                 


Val Cys Ala Asp Pro Cys Gln Ala His Arg Thr Leu Asp Glu Tyr Trp 
145                 150                 155                 160 


Arg Ser Thr Glu Tyr Gly Glu Gly Tyr Ala Cys Asp Thr Asp Leu Arg 
                165                 170                 175     


Gly Trp Tyr Arg Phe Val Gly Gln Gly Gly Ala Arg Met Ala Glu Thr 
            180                 185                 190         


Cys Val Pro Val Leu Arg Cys Asn Thr Ala Ala Pro Met Trp Leu Asn 
        195                 200                 205             


Gly Thr His Pro Ser Ser Asp Glu Gly Ile Val Ser Arg Lys Ala Cys 
    210                 215                 220                 


Ala His Trp Ser Gly His Cys Cys Leu Trp Asp Ala Ser Val Gln Val 
225                 230                 235                 240 


Lys Ala Cys Ala Gly Gly Tyr Tyr Val Tyr Asn Leu Thr Ala Pro Pro 
                245                 250                 255     


Glu Cys His Leu Ala Tyr Cys Thr Asp Pro Ser Ser Val Glu Gly Thr 
            260                 265                 270         


Cys Glu Glu Cys Ser Ile Asp Glu Asp Cys Lys Ser Asn Asn Gly Arg 
        275                 280                 285             


Trp His Cys Gln Cys Lys Gln Asp Phe Asn Ile Thr Asp Ile Ser Leu 
    290                 295                 300                 


Leu Glu His Arg Leu Glu Cys Gly Ala 
305                 310             


<210>  3
<211>  265
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3

Asp Thr Ser Glu Ala Arg Trp Cys Ser Glu Cys His Ser Asn Ala Thr 
1               5                   10                  15      


Cys Thr Glu Asp Glu Ala Val Thr Thr Cys Thr Cys Gln Glu Gly Phe 
            20                  25                  30          


Thr Gly Asp Gly Leu Thr Cys Val Asp Leu Asp Glu Cys Ala Ile Pro 
        35                  40                  45              


Gly Ala His Asn Cys Ser Ala Asn Ser Ser Cys Val Asn Thr Pro Gly 
    50                  55                  60                  


Ser Phe Ser Cys Val Cys Pro Glu Gly Phe Arg Leu Ser Pro Gly Leu 
65                  70                  75                  80  


Gly Cys Thr Asp Val Asp Glu Cys Ala Glu Pro Gly Leu Ser His Cys 
                85                  90                  95      


His Ala Leu Ala Thr Cys Val Asn Val Val Gly Ser Tyr Leu Cys Val 
            100                 105                 110         


Cys Pro Ala Gly Tyr Arg Gly Asp Gly Trp His Cys Glu Cys Ser Pro 
        115                 120                 125             


Gly Ser Cys Gly Pro Gly Leu Asp Cys Val Pro Glu Gly Asp Ala Leu 
    130                 135                 140                 


Val Cys Ala Asp Pro Cys Gln Ala His Arg Thr Leu Asp Glu Tyr Trp 
145                 150                 155                 160 


Arg Ser Thr Glu Tyr Gly Glu Gly Tyr Ala Cys Asp Thr Asp Leu Arg 
                165                 170                 175     


Gly Trp Tyr Arg Phe Val Gly Gln Gly Gly Ala Arg Met Ala Glu Thr 
            180                 185                 190         


Cys Val Pro Val Leu Arg Cys Asn Thr Ala Ala Pro Met Trp Leu Asn 
        195                 200                 205             


Gly Thr His Pro Ser Ser Asp Glu Gly Ile Val Ser Arg Lys Ala Cys 
    210                 215                 220                 


Ala His Trp Ser Gly His Cys Cys Leu Trp Asp Ala Ser Val Gln Val 
225                 230                 235                 240 


Lys Ala Cys Ala Gly Gly Tyr Tyr Val Tyr Asn Leu Thr Ala Pro Pro 
                245                 250                 255     


Glu Cys His Leu Ala Tyr Cys Thr Asp 
            260                 265 


<210>  4
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  4

Asp Thr Ser Glu Ala Arg Trp Cys Ser Glu Cys His Ser Asn Ala Thr 
1               5                   10                  15      


Cys Thr Glu Asp Glu Ala Val Thr Thr Cys Thr Cys Gln Glu Gly Phe 
            20                  25                  30          


Thr Gly Asp Gly Leu Thr Cys Val Asp Leu Asp Glu Cys Ala Ile Pro 
        35                  40                  45              


Gly Ala His Asn Cys Ser Ala Asn Ser Ser Cys Val Asn Thr Pro Gly 
    50                  55                  60                  


Ser Phe Ser Cys Val Cys Pro Glu Gly Phe Arg Leu Ser Pro Gly Leu 
65                  70                  75                  80  


Gly Cys Thr Asp Val Asp Glu Cys Ala Glu Pro Gly Leu Ser His Cys 
                85                  90                  95      


His Ala Leu Ala Thr Cys Val Asn Val Val Gly Ser Tyr Leu Cys Val 
            100                 105                 110         


Cys Pro Ala Gly Tyr Arg Gly Asp Gly Trp His Cys Glu 
        115                 120                 125 


<210>  5
<211>  590
<212>  PRT
<213>  Homo sapiens

<400>  5

Asp Thr Ser Glu Ala Arg Trp Cys Ser Glu Cys His Ser Asn Ala Thr 
1               5                   10                  15      


Cys Thr Glu Asp Glu Ala Val Thr Thr Cys Thr Cys Gln Glu Gly Phe 
            20                  25                  30          


Thr Gly Asp Gly Leu Thr Cys Val Asp Leu Asp Glu Cys Ala Ile Pro 
        35                  40                  45              


Gly Ala His Asn Cys Ser Ala Asn Ser Ser Cys Val Asn Thr Pro Gly 
    50                  55                  60                  


Ser Phe Ser Cys Val Cys Pro Glu Gly Phe Arg Leu Ser Pro Gly Leu 
65                  70                  75                  80  


Gly Cys Thr Asp Val Asp Glu Cys Ala Glu Pro Gly Leu Ser His Cys 
                85                  90                  95      


His Ala Leu Ala Thr Cys Val Asn Val Val Gly Ser Tyr Leu Cys Val 
            100                 105                 110         


Cys Pro Ala Gly Tyr Arg Gly Asp Gly Trp His Cys Glu Cys Ser Pro 
        115                 120                 125             


Gly Ser Cys Gly Pro Gly Leu Asp Cys Val Pro Glu Gly Asp Ala Leu 
    130                 135                 140                 


Val Cys Ala Asp Pro Cys Gln Ala His Arg Thr Leu Asp Glu Tyr Trp 
145                 150                 155                 160 


Arg Ser Thr Glu Tyr Gly Glu Gly Tyr Ala Cys Asp Thr Asp Leu Arg 
                165                 170                 175     


Gly Trp Tyr Arg Phe Val Gly Gln Gly Gly Ala Arg Met Ala Glu Thr 
            180                 185                 190         


Cys Val Pro Val Leu Arg Cys Asn Thr Ala Ala Pro Met Trp Leu Asn 
        195                 200                 205             


Gly Thr His Pro Ser Ser Asp Glu Gly Ile Val Ser Arg Lys Ala Cys 
    210                 215                 220                 


Ala His Trp Ser Gly His Cys Cys Leu Trp Asp Ala Ser Val Gln Val 
225                 230                 235                 240 


Lys Ala Cys Ala Gly Gly Tyr Tyr Val Tyr Asn Leu Thr Ala Pro Pro 
                245                 250                 255     


Glu Cys His Leu Ala Tyr Cys Thr Asp Pro Ser Ser Val Glu Gly Thr 
            260                 265                 270         


Cys Glu Glu Cys Ser Ile Asp Glu Asp Cys Lys Ser Asn Asn Gly Arg 
        275                 280                 285             


Trp His Cys Gln Cys Lys Gln Asp Phe Asn Ile Thr Asp Ile Ser Leu 
    290                 295                 300                 


Leu Glu His Arg Leu Glu Cys Gly Ala Asn Asp Met Lys Val Ser Leu 
305                 310                 315                 320 


Gly Lys Cys Gln Leu Lys Ser Leu Gly Phe Asp Lys Val Phe Met Tyr 
                325                 330                 335     


Leu Ser Asp Ser Arg Cys Ser Gly Phe Asn Asp Arg Asp Asn Arg Asp 
            340                 345                 350         


Trp Val Ser Val Val Thr Pro Ala Arg Asp Gly Pro Cys Gly Thr Val 
        355                 360                 365             


Leu Thr Arg Asn Glu Thr His Ala Thr Tyr Ser Asn Thr Leu Tyr Leu 
    370                 375                 380                 


Ala Asp Glu Ile Ile Ile Arg Asp Leu Asn Ile Lys Ile Asn Phe Ala 
385                 390                 395                 400 


Cys Ser Tyr Pro Leu Asp Met Lys Val Ser Leu Lys Thr Ala Leu Gln 
                405                 410                 415     


Pro Met Val Ser Ala Leu Asn Ile Arg Val Gly Gly Thr Gly Met Phe 
            420                 425                 430         


Thr Val Arg Met Ala Leu Phe Gln Thr Pro Ser Tyr Thr Gln Pro Tyr 
        435                 440                 445             


Gln Gly Ser Ser Val Thr Leu Ser Thr Glu Ala Phe Leu Tyr Val Gly 
    450                 455                 460                 


Thr Met Leu Asp Gly Gly Asp Leu Ser Arg Phe Ala Leu Leu Met Thr 
465                 470                 475                 480 


Asn Cys Tyr Ala Thr Pro Ser Ser Asn Ala Thr Asp Pro Leu Lys Tyr 
                485                 490                 495     


Phe Ile Ile Gln Asp Arg Cys Pro His Thr Arg Asp Ser Thr Ile Gln 
            500                 505                 510         


Val Val Glu Asn Gly Glu Ser Ser Gln Gly Arg Phe Ser Val Gln Met 
        515                 520                 525             


Phe Arg Phe Ala Gly Asn Tyr Asp Leu Val Tyr Leu His Cys Glu Val 
    530                 535                 540                 


Tyr Leu Cys Asp Thr Met Asn Glu Lys Cys Lys Pro Thr Cys Ser Gly 
545                 550                 555                 560 


Thr Arg Phe Arg Ser Gly Ser Val Ile Asp Gln Ser Arg Val Leu Asn 
                565                 570                 575     


Leu Gly Pro Ile Thr Arg Lys Gly Val Gln Ala Thr Val Ser 
            580                 585                 590 


<210>  6
<211>  563
<212>  PRT
<213>  Homo sapiens

<400>  6

Asp Thr Ser Glu Ala Arg Trp Cys Ser Glu Cys His Ser Asn Ala Thr 
1               5                   10                  15      


Cys Thr Glu Asp Glu Ala Val Thr Thr Cys Thr Cys Gln Glu Gly Phe 
            20                  25                  30          


Thr Gly Asp Gly Leu Thr Cys Val Asp Leu Asp Glu Cys Ala Ile Pro 
        35                  40                  45              


Gly Ala His Asn Cys Ser Ala Asn Ser Ser Cys Val Asn Thr Pro Gly 
    50                  55                  60                  


Ser Phe Ser Cys Val Cys Pro Glu Gly Phe Arg Leu Ser Pro Gly Leu 
65                  70                  75                  80  


Gly Cys Thr Asp Val Asp Glu Cys Ala Glu Pro Gly Leu Ser His Cys 
                85                  90                  95      


His Ala Leu Ala Thr Cys Val Asn Val Val Gly Ser Tyr Leu Cys Val 
            100                 105                 110         


Cys Pro Ala Gly Tyr Arg Gly Asp Gly Trp His Cys Glu Cys Ser Pro 
        115                 120                 125             


Gly Ser Cys Gly Pro Gly Leu Asp Cys Val Pro Glu Gly Asp Ala Leu 
    130                 135                 140                 


Val Cys Ala Asp Pro Cys Gln Ala His Arg Thr Leu Asp Glu Tyr Trp 
145                 150                 155                 160 


Arg Ser Thr Glu Tyr Gly Glu Gly Tyr Ala Cys Asp Thr Asp Leu Arg 
                165                 170                 175     


Gly Trp Tyr Arg Phe Val Gly Gln Gly Gly Ala Arg Met Ala Glu Thr 
            180                 185                 190         


Cys Val Pro Val Leu Arg Cys Asn Thr Ala Ala Pro Met Trp Leu Asn 
        195                 200                 205             


Gly Thr His Pro Ser Ser Asp Glu Gly Ile Val Ser Arg Lys Ala Cys 
    210                 215                 220                 


Ala His Trp Ser Gly His Cys Cys Leu Trp Asp Ala Ser Val Gln Val 
225                 230                 235                 240 


Lys Ala Cys Ala Gly Gly Tyr Tyr Val Tyr Asn Leu Thr Ala Pro Pro 
                245                 250                 255     


Glu Cys His Leu Ala Tyr Cys Thr Asp Pro Ser Ser Val Glu Gly Thr 
            260                 265                 270         


Cys Glu Glu Cys Ser Ile Asp Glu Asp Cys Lys Ser Asn Asn Gly Arg 
        275                 280                 285             


Trp His Cys Gln Cys Lys Gln Asp Phe Asn Ile Thr Asp Ile Ser Leu 
    290                 295                 300                 


Leu Glu His Arg Leu Glu Cys Gly Ala Asn Asp Met Lys Val Ser Leu 
305                 310                 315                 320 


Gly Lys Cys Gln Leu Lys Ser Leu Gly Phe Asp Lys Val Phe Met Tyr 
                325                 330                 335     


Leu Ser Asp Ser Arg Cys Ser Gly Phe Asn Asp Arg Asp Asn Arg Asp 
            340                 345                 350         


Trp Val Ser Val Val Thr Pro Ala Arg Asp Gly Pro Cys Gly Thr Val 
        355                 360                 365             


Leu Thr Arg Asn Glu Thr His Ala Thr Tyr Ser Asn Thr Leu Tyr Leu 
    370                 375                 380                 


Ala Asp Glu Ile Ile Ile Arg Asp Leu Asn Ile Lys Ile Asn Phe Ala 
385                 390                 395                 400 


Cys Ser Tyr Pro Leu Asp Met Lys Val Ser Leu Lys Thr Ala Leu Gln 
                405                 410                 415     


Pro Met Val Ser Ala Leu Asn Ile Arg Val Gly Gly Thr Gly Met Phe 
            420                 425                 430         


Thr Val Arg Met Ala Leu Phe Gln Thr Pro Ser Tyr Thr Gln Pro Tyr 
        435                 440                 445             


Gln Gly Ser Ser Val Thr Leu Ser Thr Glu Ala Phe Leu Tyr Val Gly 
    450                 455                 460                 


Thr Met Leu Asp Gly Gly Asp Leu Ser Arg Phe Ala Leu Leu Met Thr 
465                 470                 475                 480 


Asn Cys Tyr Ala Thr Pro Ser Ser Asn Ala Thr Asp Pro Leu Lys Tyr 
                485                 490                 495     


Phe Ile Ile Gln Asp Arg Cys Pro His Thr Arg Asp Ser Thr Ile Gln 
            500                 505                 510         


Val Val Glu Asn Gly Glu Ser Ser Gln Gly Arg Phe Ser Val Gln Met 
        515                 520                 525             


Phe Arg Phe Ala Gly Asn Tyr Asp Leu Val Tyr Leu His Cys Glu Val 
    530                 535                 540                 


Tyr Leu Cys Asp Thr Met Asn Glu Lys Cys Lys Pro Thr Cys Ser Gly 
545                 550                 555                 560 


Thr Arg Phe 
            


<210>  7
<211>  410
<212>  PRT
<213>  Homo sapiens

<400>  7

Asp Thr Ser Glu Ala Arg Trp Cys Ser Glu Cys His Ser Asn Ala Thr 
1               5                   10                  15      


Cys Thr Glu Asp Glu Ala Val Thr Thr Cys Thr Cys Gln Glu Gly Phe 
            20                  25                  30          


Thr Gly Asp Gly Leu Thr Cys Val Asp Leu Asp Glu Cys Ala Ile Pro 
        35                  40                  45              


Gly Ala His Asn Cys Ser Ala Asn Ser Ser Cys Val Asn Thr Pro Gly 
    50                  55                  60                  


Ser Phe Ser Cys Val Cys Pro Glu Gly Phe Arg Leu Ser Pro Gly Leu 
65                  70                  75                  80  


Gly Cys Thr Asp Val Asp Glu Cys Ala Glu Pro Gly Leu Ser His Cys 
                85                  90                  95      


His Ala Leu Ala Thr Cys Val Asn Val Val Gly Ser Tyr Leu Cys Val 
            100                 105                 110         


Cys Pro Ala Gly Tyr Arg Gly Asp Gly Trp His Cys Glu Cys Ser Pro 
        115                 120                 125             


Gly Ser Cys Gly Pro Gly Leu Asp Cys Val Pro Glu Gly Asp Ala Leu 
    130                 135                 140                 


Val Cys Ala Asp Pro Cys Gln Ala His Arg Thr Leu Asp Glu Tyr Trp 
145                 150                 155                 160 


Arg Ser Thr Glu Tyr Gly Glu Gly Tyr Ala Cys Asp Thr Asp Leu Arg 
                165                 170                 175     


Gly Trp Tyr Arg Phe Val Gly Gln Gly Gly Ala Arg Met Ala Glu Thr 
            180                 185                 190         


Cys Val Pro Val Leu Arg Cys Asn Thr Ala Ala Pro Met Trp Leu Asn 
        195                 200                 205             


Gly Thr His Pro Ser Ser Asp Glu Gly Ile Val Ser Arg Lys Ala Cys 
    210                 215                 220                 


Ala His Trp Ser Gly His Cys Cys Leu Trp Asp Ala Ser Val Gln Val 
225                 230                 235                 240 


Lys Ala Cys Ala Gly Gly Tyr Tyr Val Tyr Asn Leu Thr Ala Pro Pro 
                245                 250                 255     


Glu Cys His Leu Ala Tyr Cys Thr Asp Pro Ser Ser Val Glu Gly Thr 
            260                 265                 270         


Cys Glu Glu Cys Ser Ile Asp Glu Asp Cys Lys Ser Asn Asn Gly Arg 
        275                 280                 285             


Trp His Cys Gln Cys Lys Gln Asp Phe Asn Ile Thr Asp Ile Ser Leu 
    290                 295                 300                 


Leu Glu His Arg Leu Glu Cys Gly Ala Asn Asp Met Lys Val Ser Leu 
305                 310                 315                 320 


Gly Lys Cys Gln Leu Lys Ser Leu Gly Phe Asp Lys Val Phe Met Tyr 
                325                 330                 335     


Leu Ser Asp Ser Arg Cys Ser Gly Phe Asn Asp Arg Asp Asn Arg Asp 
            340                 345                 350         


Trp Val Ser Val Val Thr Pro Ala Arg Asp Gly Pro Cys Gly Thr Val 
        355                 360                 365             


Leu Thr Arg Asn Glu Thr His Ala Thr Tyr Ser Asn Thr Leu Tyr Leu 
    370                 375                 380                 


Ala Asp Glu Ile Ile Ile Arg Asp Leu Asn Ile Lys Ile Asn Phe Ala 
385                 390                 395                 400 


Cys Ser Tyr Pro Leu Asp Met Lys Val Ser 
                405                 410 


