                         SEQUENCE LISTING

<110>  Dana-Farber Cancer Institute, Inc.
 
<120>  Methods For Identification, Assessment, Prevention, And Treatment
       Of Metabolic Disorders Using PM20D1 And N-Lipidated Amino Acids

<130>  DFS-163.25

<140>  PCT/US2016/059289
<141>  2016-10-28

<150>  US 62/355,120
<151>  2016-06-27

<150>  US 62/248,365
<151>  2015-10-30

<150>  US 62/248,007
<151>  2015-10-29

<160>  39    

<170>  PatentIn version 3.5

<210>  1
<211>  1509
<212>  DNA
<213>  Homo sapiens

<400>  1
atggctcagc ggtgcgtttg cgtgctggcc ctggtggcta tgctgctcct agttttccct       60

accgtctcca gatcgatggg cccgaggagc ggggagcatc aaagggcgtc gcgaatccct      120

tctcagttca gcaaagagga acgcgtcgcg atgaaagagg cgctgaaagg tgccatccag      180

attccaacag tgacttttag ctctgagaag tccaatacta cagccctggc tgagttcgga      240

aaatacattc ataaagtctt tcctacagtg gtcagcacca gctttatcca gcatgaagtc      300

gtggaagagt atagccacct gttcactatc caaggctcgg accccagctt gcagccctac      360

ctgctgatgg ctcactttga tgtggtgcct gcccctgaag aaggctggga ggtgccccca      420

ttctctgggt tggagcgtga tggcatcatc tatggtcggg gcacactgga cgacaagaac      480

tctgtgatgg cattactgca ggccttggag ctcctgctga tcaggaagta catcccccga      540

agatctttct tcatttctct gggccatgat gaggagtcat cagggacagg ggctcagagg      600

atctcagccc tgctacagtc aaggggcgtc cagctagcct tcattgtgga cgaggggggc      660

ttcatcttgg atgatttcat tcctaacttc aagaagccca tcgccttgat tgcagtctca      720

gagaagggtt ccatgaacct catgctgcaa gtaaacatga cttcaggcca ctcttcagct      780

cctccaaagg agacaagcat tggcatcctt gcagctgctg tcagccgatt ggagcagaca      840

ccaatgccta tcatatttgg aagcgggaca gtggtgactg tattgcagca actggcaaat      900

gagtttccct tccctgtcaa tataatcctg agcaacccat ggctatttga accacttata      960

agcaggttta tggagagaaa tcccttaacc aatgcaataa tcaggaccac cacggcactc     1020

accatattca aagcaggggt caagttcaat gtcatccccc cagtggccca ggccacagtc     1080

aacttccgga ttcaccctgg acagacagtc caagaggtcc tagaactcac gaagaacatt     1140

gtggctgata acagagtcca gttccatgtg ttgagtgcct ttgaccccct ccccgtcagc     1200

ccttctgatg acaaggcctt gggctaccag ctgctccgcc agaccgtaca gtccgtcttc     1260

ccggaagtca atattactgc cccagttact tctattggca acacagacag ccgattcttt     1320

acaaacctca ccactggcat ctacaggttc taccccatct acatacagcc tgaagacttc     1380

aaacgcatcc atggagtcaa cgagaaaatc tcagtccaag cctatgagac ccaagtgaaa     1440

ttcatctttg agttgattca gaatgctgac acagaccagg agccagtttc tcacctgcac     1500

aaactgtga                                                             1509


<210>  2
<211>  502
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ala Gln Arg Cys Val Cys Val Leu Ala Leu Val Ala Met Leu Leu 
1               5                   10                  15      


Leu Val Phe Pro Thr Val Ser Arg Ser Met Gly Pro Arg Ser Gly Glu 
            20                  25                  30          


His Gln Arg Ala Ser Arg Ile Pro Ser Gln Phe Ser Lys Glu Glu Arg 
        35                  40                  45              


Val Ala Met Lys Glu Ala Leu Lys Gly Ala Ile Gln Ile Pro Thr Val 
    50                  55                  60                  


Thr Phe Ser Ser Glu Lys Ser Asn Thr Thr Ala Leu Ala Glu Phe Gly 
65                  70                  75                  80  


Lys Tyr Ile His Lys Val Phe Pro Thr Val Val Ser Thr Ser Phe Ile 
                85                  90                  95      


Gln His Glu Val Val Glu Glu Tyr Ser His Leu Phe Thr Ile Gln Gly 
            100                 105                 110         


Ser Asp Pro Ser Leu Gln Pro Tyr Leu Leu Met Ala His Phe Asp Val 
        115                 120                 125             


Val Pro Ala Pro Glu Glu Gly Trp Glu Val Pro Pro Phe Ser Gly Leu 
    130                 135                 140                 


Glu Arg Asp Gly Ile Ile Tyr Gly Arg Gly Thr Leu Asp Asp Lys Asn 
145                 150                 155                 160 


Ser Val Met Ala Leu Leu Gln Ala Leu Glu Leu Leu Leu Ile Arg Lys 
                165                 170                 175     


Tyr Ile Pro Arg Arg Ser Phe Phe Ile Ser Leu Gly His Asp Glu Glu 
            180                 185                 190         


Ser Ser Gly Thr Gly Ala Gln Arg Ile Ser Ala Leu Leu Gln Ser Arg 
        195                 200                 205             


Gly Val Gln Leu Ala Phe Ile Val Asp Glu Gly Gly Phe Ile Leu Asp 
    210                 215                 220                 


Asp Phe Ile Pro Asn Phe Lys Lys Pro Ile Ala Leu Ile Ala Val Ser 
225                 230                 235                 240 


Glu Lys Gly Ser Met Asn Leu Met Leu Gln Val Asn Met Thr Ser Gly 
                245                 250                 255     


His Ser Ser Ala Pro Pro Lys Glu Thr Ser Ile Gly Ile Leu Ala Ala 
            260                 265                 270         


Ala Val Ser Arg Leu Glu Gln Thr Pro Met Pro Ile Ile Phe Gly Ser 
        275                 280                 285             


Gly Thr Val Val Thr Val Leu Gln Gln Leu Ala Asn Glu Phe Pro Phe 
    290                 295                 300                 


Pro Val Asn Ile Ile Leu Ser Asn Pro Trp Leu Phe Glu Pro Leu Ile 
305                 310                 315                 320 


Ser Arg Phe Met Glu Arg Asn Pro Leu Thr Asn Ala Ile Ile Arg Thr 
                325                 330                 335     


Thr Thr Ala Leu Thr Ile Phe Lys Ala Gly Val Lys Phe Asn Val Ile 
            340                 345                 350         


Pro Pro Val Ala Gln Ala Thr Val Asn Phe Arg Ile His Pro Gly Gln 
        355                 360                 365             


Thr Val Gln Glu Val Leu Glu Leu Thr Lys Asn Ile Val Ala Asp Asn 
    370                 375                 380                 


Arg Val Gln Phe His Val Leu Ser Ala Phe Asp Pro Leu Pro Val Ser 
385                 390                 395                 400 


Pro Ser Asp Asp Lys Ala Leu Gly Tyr Gln Leu Leu Arg Gln Thr Val 
                405                 410                 415     


Gln Ser Val Phe Pro Glu Val Asn Ile Thr Ala Pro Val Thr Ser Ile 
            420                 425                 430         


Gly Asn Thr Asp Ser Arg Phe Phe Thr Asn Leu Thr Thr Gly Ile Tyr 
        435                 440                 445             


Arg Phe Tyr Pro Ile Tyr Ile Gln Pro Glu Asp Phe Lys Arg Ile His 
    450                 455                 460                 


Gly Val Asn Glu Lys Ile Ser Val Gln Ala Tyr Glu Thr Gln Val Lys 
465                 470                 475                 480 


Phe Ile Phe Glu Leu Ile Gln Asn Ala Asp Thr Asp Gln Glu Pro Val 
                485                 490                 495     


Ser His Leu His Lys Leu 
            500         


<210>  3
<211>  1512
<212>  DNA
<213>  Mus musculus

<400>  3
atggctgagc tacttgctag cttgcccgcc tgggcagctg tgctccttct ctttttcgct       60

acggtctccg gatccactgg ccctagaagc agggaaaatc ggggggcgtc ccggatccct      120

tcccagttca gcgaggagga gcgtgtcgct ataaaagagg cgctgaaagg tgccatccag      180

attcccacag tgtctttcag ccacgaggaa tccaacacca cagcccttgc tgagtttgga      240

gaatatatcc gcaaagcctt ccctacagtg ttccacagca gccttgtcca acatgaagtc      300

gtggcaaagt atagccacct gttcaccatc caaggctcag accccagttt gcagccctac      360

atgctgatgg ctcacattga tgtggttcct gccccggaag aaggatggga ggtgcccccg      420

ttctcaggcc tggaacgcaa tggcttcatc tatggccggg gtgcgctgga caacaaaaac      480

tctgtgatgg cgatcctgca tgctttggag ctcctgttga tcagaaacta cagccccaaa      540

agatctttct tcattgcttt gggccatgat gaggaggtgt ccggggaaaa gggggctcag      600

aagatctcag cactcttaca ggcaaggggt gtccagctag ccttccttgt ggatgaaggg      660

agctttatct tggaaggctt cattccaaac ctcgagaagc cagttgccat gatttcagtc      720

actgagaagg gtgcccttga cctcatgctg caagtaaaca tgactccagg ccactcttca      780

gctcccccaa aggagacaag cattggcatt ctttctgccg ctgtcagccg actggagcag      840

acaccaatgc cgaatatgtt tggaggaggg ccattgaaga agacaatgaa gctactggca      900

aatgagtttt ccttccctat caatatagtc ttgagaaacc tgtggctatt tcatcccatt      960

gtgagcagga taatggagag gaaccccata acaaatgcgc tggtccgaac taccacagcc     1020

ctcaccatgt tcaatgcagg aatcaaggtg aatgtcatcc ctccattggc tcaggctaca     1080

atcaactgcc gaattcaccc ttcgcagaca gtacatgagg tcctagaact tgtcaagaac     1140

accgtggctg atgacagagt ccagctgcat gtgttgagat cctttgaacc cctgcccatc     1200

agcccctctg atgaccaggc catgggctac cagctgcttc aagagaccat acgatctgtc     1260

ttcccggaag tcgacatcgt cgtccccggt atttgtattg ccaatacgga cacccgacac     1320

tatgccaaca tcaccaatgg catgtaccgg ttcaaccccc ttcccctgaa ccctcaggac     1380

ttcagtggtg tccatggaat caatgagaaa gtttccgttc agaactacca gaaccaggtg     1440

aagttcatct ttgagttcat ccaaaatgcc gacacttaca aagagccagt tcctcatctg     1500

catgaactat ga                                                         1512


<210>  4
<211>  503
<212>  PRT
<213>  Mus musculus

<400>  4

Met Ala Glu Leu Leu Ala Ser Leu Pro Ala Trp Ala Ala Val Leu Leu 
1               5                   10                  15      


Leu Phe Phe Ala Thr Val Ser Gly Ser Thr Gly Pro Arg Ser Arg Glu 
            20                  25                  30          


Asn Arg Gly Ala Ser Arg Ile Pro Ser Gln Phe Ser Glu Glu Glu Arg 
        35                  40                  45              


Val Ala Ile Lys Glu Ala Leu Lys Gly Ala Ile Gln Ile Pro Thr Val 
    50                  55                  60                  


Ser Phe Ser His Glu Glu Ser Asn Thr Thr Ala Leu Ala Glu Phe Gly 
65                  70                  75                  80  


Glu Tyr Ile Arg Lys Ala Phe Pro Thr Val Phe His Ser Ser Leu Val 
                85                  90                  95      


Gln His Glu Val Val Ala Lys Tyr Ser His Leu Phe Thr Ile Gln Gly 
            100                 105                 110         


Ser Asp Pro Ser Leu Gln Pro Tyr Met Leu Met Ala His Ile Asp Val 
        115                 120                 125             


Val Pro Ala Pro Glu Glu Gly Trp Glu Val Pro Pro Phe Ser Gly Leu 
    130                 135                 140                 


Glu Arg Asn Gly Phe Ile Tyr Gly Arg Gly Ala Leu Asp Asn Lys Asn 
145                 150                 155                 160 


Ser Val Met Ala Ile Leu His Ala Leu Glu Leu Leu Leu Ile Arg Asn 
                165                 170                 175     


Tyr Ser Pro Lys Arg Ser Phe Phe Ile Ala Leu Gly His Asp Glu Glu 
            180                 185                 190         


Val Ser Gly Glu Lys Gly Ala Gln Lys Ile Ser Ala Leu Leu Gln Ala 
        195                 200                 205             


Arg Gly Val Gln Leu Ala Phe Leu Val Asp Glu Gly Ser Phe Ile Leu 
    210                 215                 220                 


Glu Gly Phe Ile Pro Asn Leu Glu Lys Pro Val Ala Met Ile Ser Val 
225                 230                 235                 240 


Thr Glu Lys Gly Ala Leu Asp Leu Met Leu Gln Val Asn Met Thr Pro 
                245                 250                 255     


Gly His Ser Ser Ala Pro Pro Lys Glu Thr Ser Ile Gly Ile Leu Ser 
            260                 265                 270         


Ala Ala Val Ser Arg Leu Glu Gln Thr Pro Met Pro Asn Met Phe Gly 
        275                 280                 285             


Gly Gly Pro Leu Lys Lys Thr Met Lys Leu Leu Ala Asn Glu Phe Ser 
    290                 295                 300                 


Phe Pro Ile Asn Ile Val Leu Arg Asn Leu Trp Leu Phe His Pro Ile 
305                 310                 315                 320 


Val Ser Arg Ile Met Glu Arg Asn Pro Ile Thr Asn Ala Leu Val Arg 
                325                 330                 335     


Thr Thr Thr Ala Leu Thr Met Phe Asn Ala Gly Ile Lys Val Asn Val 
            340                 345                 350         


Ile Pro Pro Leu Ala Gln Ala Thr Ile Asn Cys Arg Ile His Pro Ser 
        355                 360                 365             


Gln Thr Val His Glu Val Leu Glu Leu Val Lys Asn Thr Val Ala Asp 
    370                 375                 380                 


Asp Arg Val Gln Leu His Val Leu Arg Ser Phe Glu Pro Leu Pro Ile 
385                 390                 395                 400 


Ser Pro Ser Asp Asp Gln Ala Met Gly Tyr Gln Leu Leu Gln Glu Thr 
                405                 410                 415     


Ile Arg Ser Val Phe Pro Glu Val Asp Ile Val Val Pro Gly Ile Cys 
            420                 425                 430         


Ile Ala Asn Thr Asp Thr Arg His Tyr Ala Asn Ile Thr Asn Gly Met 
        435                 440                 445             


Tyr Arg Phe Asn Pro Leu Pro Leu Asn Pro Gln Asp Phe Ser Gly Val 
    450                 455                 460                 


His Gly Ile Asn Glu Lys Val Ser Val Gln Asn Tyr Gln Asn Gln Val 
465                 470                 475                 480 


Lys Phe Ile Phe Glu Phe Ile Gln Asn Ala Asp Thr Tyr Lys Glu Pro 
                485                 490                 495     


Val Pro His Leu His Glu Leu 
            500             


<210>  5
<211>  1509
<212>  DNA
<213>  Pan troglodytes

<400>  5
atggctcagc ggtgcgtttg cgtgctggcc ctggtggcta tgctgctcct agttttcccc       60

accgtctcca gatcgatggg cctgaggagc ggggagcatc aaagggcgtc gcgaatccct      120

tctcagttca gcaaagagga acgcgtcgcg atgaaagagg cgctgaaagg tgccatccag      180

attccaacag tgacttttag ctctgagaag tccaatacca cagccctggc tgagttcgga      240

aaatacattc ataaagtctt tcctacagtg gtcagcacca gctttatcca gcatgaagtt      300

gtggaagagt atagccacct gttcactatc caaggctcgg accccagctt gcagccctac      360

ttgctgatgg ctcactttga tgtggtgcct gcccctgaag aaggctggga ggtgccccca      420

ttctctgggt tggagcgtga tggcgtcatc tatggtcggg gcacactaga cgacaagaac      480

tctgtgatgg cattactgca ggccttggag ctcctgctga tcaggaagta catcccccaa      540

agatctttct tcatttctct gggccatgat gaggagtcgt cagggacagg ggctcagagg      600

atctcagccc tgctacagtc aaggggcgtc cagctagcct tcattgtgga cgaggggggc      660

ttcatcttgg atgatttcat tcctaacttc aagaagccca tcgccttgat tgcagtctca      720

gagaagggtt ccatgaacct catgctgcaa gtaaacatga cttcaggcca ctcttcagct      780

cctccaaagg agacgagcat tggcatcctt gcagctgctg tcagccgatt ggagcagaca      840

ccaatgccta tcatatttgg aagcgggaca ttggtgacgg tattgcagca actggcaaat      900

gagtttccct tccctgtcaa tataatcctg agcaacccat ggctatttga accacttata      960

agcaggttta tggagagaaa tcccttaacc aatgcaataa tcaggaccac cacggcactc     1020

accatattca aagcaggggt caagttcaat gtcatccccc cggtggccca ggccacagtc     1080

aacttccgga ttcaccctgg acagacagtc caagaggtcc tagaactcac gaagaacatt     1140

gtggctgata acagagtcca gttccatgtg ttgagtgcct ttgaccccct ccccgtcagc     1200

ccttctgatg acaaggcctt gggctaccag ctgctccgcc agaccgtaca gtccgtcttc     1260

ccggaagtca atattactgc cccagttact tctattggca acacagacag ccgattcttt     1320

acaaacctca ccactggcat ctacaggttc taccccatct acatacagcc tgaagacttc     1380

aaacgcatcc atggagtcaa cgagaaaatc tcagtccaag cctatgagac ccaagtgaaa     1440

ttcatctttg agttgattca gaatgctgac acagaccagg agccagtttc tcacctgcac     1500

aaactgtga                                                             1509


<210>  6
<211>  502
<212>  PRT
<213>  Pan troglodytes

<400>  6

Met Ala Gln Arg Cys Val Cys Val Leu Ala Leu Val Ala Met Leu Leu 
1               5                   10                  15      


Leu Val Phe Pro Thr Val Ser Arg Ser Met Gly Leu Arg Ser Gly Glu 
            20                  25                  30          


His Gln Arg Ala Ser Arg Ile Pro Ser Gln Phe Ser Lys Glu Glu Arg 
        35                  40                  45              


Val Ala Met Lys Glu Ala Leu Lys Gly Ala Ile Gln Ile Pro Thr Val 
    50                  55                  60                  


Thr Phe Ser Ser Glu Lys Ser Asn Thr Thr Ala Leu Ala Glu Phe Gly 
65                  70                  75                  80  


Lys Tyr Ile His Lys Val Phe Pro Thr Val Val Ser Thr Ser Phe Ile 
                85                  90                  95      


Gln His Glu Val Val Glu Glu Tyr Ser His Leu Phe Thr Ile Gln Gly 
            100                 105                 110         


Ser Asp Pro Ser Leu Gln Pro Tyr Leu Leu Met Ala His Phe Asp Val 
        115                 120                 125             


Val Pro Ala Pro Glu Glu Gly Trp Glu Val Pro Pro Phe Ser Gly Leu 
    130                 135                 140                 


Glu Arg Asp Gly Val Ile Tyr Gly Arg Gly Thr Leu Asp Asp Lys Asn 
145                 150                 155                 160 


Ser Val Met Ala Leu Leu Gln Ala Leu Glu Leu Leu Leu Ile Arg Lys 
                165                 170                 175     


Tyr Ile Pro Gln Arg Ser Phe Phe Ile Ser Leu Gly His Asp Glu Glu 
            180                 185                 190         


Ser Ser Gly Thr Gly Ala Gln Arg Ile Ser Ala Leu Leu Gln Ser Arg 
        195                 200                 205             


Gly Val Gln Leu Ala Phe Ile Val Asp Glu Gly Gly Phe Ile Leu Asp 
    210                 215                 220                 


Asp Phe Ile Pro Asn Phe Lys Lys Pro Ile Ala Leu Ile Ala Val Ser 
225                 230                 235                 240 


Glu Lys Gly Ser Met Asn Leu Met Leu Gln Val Asn Met Thr Ser Gly 
                245                 250                 255     


His Ser Ser Ala Pro Pro Lys Glu Thr Ser Ile Gly Ile Leu Ala Ala 
            260                 265                 270         


Ala Val Ser Arg Leu Glu Gln Thr Pro Met Pro Ile Ile Phe Gly Ser 
        275                 280                 285             


Gly Thr Leu Val Thr Val Leu Gln Gln Leu Ala Asn Glu Phe Pro Phe 
    290                 295                 300                 


Pro Val Asn Ile Ile Leu Ser Asn Pro Trp Leu Phe Glu Pro Leu Ile 
305                 310                 315                 320 


Ser Arg Phe Met Glu Arg Asn Pro Leu Thr Asn Ala Ile Ile Arg Thr 
                325                 330                 335     


Thr Thr Ala Leu Thr Ile Phe Lys Ala Gly Val Lys Phe Asn Val Ile 
            340                 345                 350         


Pro Pro Val Ala Gln Ala Thr Val Asn Phe Arg Ile His Pro Gly Gln 
        355                 360                 365             


Thr Val Gln Glu Val Leu Glu Leu Thr Lys Asn Ile Val Ala Asp Asn 
    370                 375                 380                 


Arg Val Gln Phe His Val Leu Ser Ala Phe Asp Pro Leu Pro Val Ser 
385                 390                 395                 400 


Pro Ser Asp Asp Lys Ala Leu Gly Tyr Gln Leu Leu Arg Gln Thr Val 
                405                 410                 415     


Gln Ser Val Phe Pro Glu Val Asn Ile Thr Ala Pro Val Thr Ser Ile 
            420                 425                 430         


Gly Asn Thr Asp Ser Arg Phe Phe Thr Asn Leu Thr Thr Gly Ile Tyr 
        435                 440                 445             


Arg Phe Tyr Pro Ile Tyr Ile Gln Pro Glu Asp Phe Lys Arg Ile His 
    450                 455                 460                 


Gly Val Asn Glu Lys Ile Ser Val Gln Ala Tyr Glu Thr Gln Val Lys 
465                 470                 475                 480 


Phe Ile Phe Glu Leu Ile Gln Asn Ala Asp Thr Asp Gln Glu Pro Val 
                485                 490                 495     


Ser His Leu His Lys Leu 
            500         


<210>  7
<211>  1512
<212>  DNA
<213>  Bos taurus

<400>  7
atggctcggc cgtccgtctg cctgctggcc tcgctgtctg cgctgctcct aggtatcgcc       60

gccgtctcca gatcgaaggg cctgcggggc acggagagtc aaagggagcc gcgaatccct      120

tctcagttca gccaagagca gcgcatcgcc atgaaggaag cgctcaaagg tgccatccag      180

attccaacag tgtctttcag ccccaaggag ctcaacacaa cagccctggc tgagtttgga      240

gaatacattc gtaaagtctt tcctactgtg ttccatacca gctttatccg gcatgaggtc      300

gtaggaaatt acagccacct gttcactatc aaaggctcag accccagcat gcagccctac      360

attctcctcg ctcacattga cgtggtgcct gccccggaca aaggctggga cgtgcccccc      420

ttctctgggt tggagcgtga tggcttcatc tatggtcgag gcacactgga caacaagaac      480

tatcttatgg caatcctgca ggccttggag cttctgctga tcagaaacta catcccccga      540

agatctttct tcattgctct gggccatgat gaggagatat cagggataaa cggggctcag      600

aagatctcag ccctgctaca ggcaaggggt gtccagctag ccttcgtggt ggatgagggg      660

agcttcatct tggacggttt cattccctac ctcaagaagc cctttgccat ggtttccgtt      720

tctgagaagg gtgcgattaa cctcatgctg caagtcaaca cgactacagg ccactcttca      780

gctcctccaa aagaaacaag cataggcatt ctcgcagccg cagtcagccg actggagcag      840

acaccaatgc cgaacatgtt tggaagtggg ccattgatga cggcagtgga gcaactggca      900

aatgagtttc ccttccctac caatatagtc ttgaacaacc tgtggctctt tcgacccctt      960

gtaagcaggt tgatggagag gaattacata accaattcgc tggtcaggac cacaacggcg     1020

ctcaccatgt tcaatgccgg ggtcaaggtg aatgtcatcc cccctgtggc cgaggccatc     1080

atcaacttcc gacttcaccc tgcacagact gttcaggagg ttctaaaatt agccaaggac     1140

attgtggctg atgaccgcat ccagttccat gtgttggatg cctttgaccc cctgcccatc     1200

agcccttctg atgatcaggc cttgggttac cagctgctcc gccagaccat acactctgtc     1260

ttcccggaag tcaacattgt tgccccaggt acttgtattg gcaacacaga cagcagacac     1320

tatctgaatc ttaccactgg catctaccgg ttcaacccca tctacctaca acctcaggac     1380

ttcagtagca tccacggaat caatgagaaa atctcggtcc aagcctacga gacccaggtg     1440

aaattcgtct tcgagtttat ccagaatggt gacacagacg aggagacagt tcctcacctg     1500

catgaactgt ga                                                         1512


<210>  8
<211>  503
<212>  PRT
<213>  Bos taurus

<400>  8

Met Ala Arg Pro Ser Val Cys Leu Leu Ala Ser Leu Ser Ala Leu Leu 
1               5                   10                  15      


Leu Gly Ile Ala Ala Val Ser Arg Ser Lys Gly Leu Arg Gly Thr Glu 
            20                  25                  30          


Ser Gln Arg Glu Pro Arg Ile Pro Ser Gln Phe Ser Gln Glu Gln Arg 
        35                  40                  45              


Ile Ala Met Lys Glu Ala Leu Lys Gly Ala Ile Gln Ile Pro Thr Val 
    50                  55                  60                  


Ser Phe Ser Pro Lys Glu Leu Asn Thr Thr Ala Leu Ala Glu Phe Gly 
65                  70                  75                  80  


Glu Tyr Ile Arg Lys Val Phe Pro Thr Val Phe His Thr Ser Phe Ile 
                85                  90                  95      


Arg His Glu Val Val Gly Asn Tyr Ser His Leu Phe Thr Ile Lys Gly 
            100                 105                 110         


Ser Asp Pro Ser Met Gln Pro Tyr Ile Leu Leu Ala His Ile Asp Val 
        115                 120                 125             


Val Pro Ala Pro Asp Lys Gly Trp Asp Val Pro Pro Phe Ser Gly Leu 
    130                 135                 140                 


Glu Arg Asp Gly Phe Ile Tyr Gly Arg Gly Thr Leu Asp Asn Lys Asn 
145                 150                 155                 160 


Tyr Leu Met Ala Ile Leu Gln Ala Leu Glu Leu Leu Leu Ile Arg Asn 
                165                 170                 175     


Tyr Ile Pro Arg Arg Ser Phe Phe Ile Ala Leu Gly His Asp Glu Glu 
            180                 185                 190         


Ile Ser Gly Ile Asn Gly Ala Gln Lys Ile Ser Ala Leu Leu Gln Ala 
        195                 200                 205             


Arg Gly Val Gln Leu Ala Phe Val Val Asp Glu Gly Ser Phe Ile Leu 
    210                 215                 220                 


Asp Gly Phe Ile Pro Tyr Leu Lys Lys Pro Phe Ala Met Val Ser Val 
225                 230                 235                 240 


Ser Glu Lys Gly Ala Ile Asn Leu Met Leu Gln Val Asn Thr Thr Thr 
                245                 250                 255     


Gly His Ser Ser Ala Pro Pro Lys Glu Thr Ser Ile Gly Ile Leu Ala 
            260                 265                 270         


Ala Ala Val Ser Arg Leu Glu Gln Thr Pro Met Pro Asn Met Phe Gly 
        275                 280                 285             


Ser Gly Pro Leu Met Thr Ala Val Glu Gln Leu Ala Asn Glu Phe Pro 
    290                 295                 300                 


Phe Pro Thr Asn Ile Val Leu Asn Asn Leu Trp Leu Phe Arg Pro Leu 
305                 310                 315                 320 


Val Ser Arg Leu Met Glu Arg Asn Tyr Ile Thr Asn Ser Leu Val Arg 
                325                 330                 335     


Thr Thr Thr Ala Leu Thr Met Phe Asn Ala Gly Val Lys Val Asn Val 
            340                 345                 350         


Ile Pro Pro Val Ala Glu Ala Ile Ile Asn Phe Arg Leu His Pro Ala 
        355                 360                 365             


Gln Thr Val Gln Glu Val Leu Lys Leu Ala Lys Asp Ile Val Ala Asp 
    370                 375                 380                 


Asp Arg Ile Gln Phe His Val Leu Asp Ala Phe Asp Pro Leu Pro Ile 
385                 390                 395                 400 


Ser Pro Ser Asp Asp Gln Ala Leu Gly Tyr Gln Leu Leu Arg Gln Thr 
                405                 410                 415     


Ile His Ser Val Phe Pro Glu Val Asn Ile Val Ala Pro Gly Thr Cys 
            420                 425                 430         


Ile Gly Asn Thr Asp Ser Arg His Tyr Leu Asn Leu Thr Thr Gly Ile 
        435                 440                 445             


Tyr Arg Phe Asn Pro Ile Tyr Leu Gln Pro Gln Asp Phe Ser Ser Ile 
    450                 455                 460                 


His Gly Ile Asn Glu Lys Ile Ser Val Gln Ala Tyr Glu Thr Gln Val 
465                 470                 475                 480 


Lys Phe Val Phe Glu Phe Ile Gln Asn Gly Asp Thr Asp Glu Glu Thr 
                485                 490                 495     


Val Pro His Leu His Glu Leu 
            500             


<210>  9
<211>  1512
<212>  DNA
<213>  Rattus norvegicus

<400>  9
atggctgagc tacttgttat cttgcccacc cgggcagctg tgctccttct ctttttcgct       60

accgtctcag gatccacggg ccctggcagc agggaaagtc gaggatcgtc gcggatccct      120

tcccagttca gcgaggagga gcgcgtcgct atgaaagagg cgctgaaagg tgccatccgg      180

attcccacag tgtctttcag ccacgaggaa tccaacacca cagcccttgc tgagtttgga      240

gaatatatcc gaaaagcctt tcctacagtg ttccacagca accttatcca acacgaagtc      300

gtggggaagt atagccacct gctcaccgtc cgaggctcgg accccagttt gcagccctac      360

atgctgatgg ctcacttcga cgtggttcct gcctctgaag aaggatggga ggtgcccccg      420

ttctcaggcc tggagcaaaa tggcttcatc catggccggg gtgcgctgga caacaaaaac      480

tctgtgatgg cagtcctgca ggctttggag ctcctgttga tcagaaaata cagccccaaa      540

agacctttct tcattgcttt gggccatgat gaggaggtgt ctgggacaaa gggggctcag      600

cagatctcag cactcttaca gacgaggggt gtccagctag cttttcttgt ggatgaaggg      660

agctttatct tggaagactt cattccgaac ctcaagaagc cgtttgccat gatttcagtc      720

accgagaagg gtgcccttga cctcatgctg caagtaaaca tgactccagg ccactcttca      780

gctcccccaa aggagacaag cattggaatc ctttctgccg ctgtcagccg actggagcag      840

acaccaatgc caaacatgtt tggaaacggg ccattgaaga agacattgaa gctactggca      900

aatgagtttt ccttccctac caatataatc ttggggaacc tgtggctatt ccgtcccatt      960

gtaagcaggg taatggagag gaatcccata acgaatgcat tggtcagaac taccacagcc     1020

ctcaccatgt tcaatgcagg aatcaaggtg aatgtcatcc ccccattggc tcaggcgaca     1080

gtcaacttcc gaattcaccc ttcgcagaca gtacacgagg tcgtagaact cgtccagaac     1140

attgtggctg atgaccgagt ccagttgcat gtgttgagat cctttgaacc actgcccgtc     1200

agcccctctg atgaccaggc catgggctac cagctgcttc aacagaccat acagtctgtc     1260

ttcccggaag tcaagatcat tgtccccggt atttgtattg gcaacacgga cacccgacac     1320

tatgtcaacc tgaccaatgg cttgtaccgg ttcaaccccg ttttcctgaa gcctcaggac     1380

ttcagtagtg tccatggaat caatgagaaa atctccgttg agagctacca gaaccaggtg     1440

aagttcatct ttgagttgat ccaaaatgct gacacctaca gcaagccagt tcctcatcag     1500

catgaactat ga                                                         1512


<210>  10
<211>  503
<212>  PRT
<213>  Rattus norvegicus

<400>  10

Met Ala Glu Leu Leu Val Ile Leu Pro Thr Arg Ala Ala Val Leu Leu 
1               5                   10                  15      


Leu Phe Phe Ala Thr Val Ser Gly Ser Thr Gly Pro Gly Ser Arg Glu 
            20                  25                  30          


Ser Arg Gly Ser Ser Arg Ile Pro Ser Gln Phe Ser Glu Glu Glu Arg 
        35                  40                  45              


Val Ala Met Lys Glu Ala Leu Lys Gly Ala Ile Arg Ile Pro Thr Val 
    50                  55                  60                  


Ser Phe Ser His Glu Glu Ser Asn Thr Thr Ala Leu Ala Glu Phe Gly 
65                  70                  75                  80  


Glu Tyr Ile Arg Lys Ala Phe Pro Thr Val Phe His Ser Asn Leu Ile 
                85                  90                  95      


Gln His Glu Val Val Gly Lys Tyr Ser His Leu Leu Thr Val Arg Gly 
            100                 105                 110         


Ser Asp Pro Ser Leu Gln Pro Tyr Met Leu Met Ala His Phe Asp Val 
        115                 120                 125             


Val Pro Ala Ser Glu Glu Gly Trp Glu Val Pro Pro Phe Ser Gly Leu 
    130                 135                 140                 


Glu Gln Asn Gly Phe Ile His Gly Arg Gly Ala Leu Asp Asn Lys Asn 
145                 150                 155                 160 


Ser Val Met Ala Val Leu Gln Ala Leu Glu Leu Leu Leu Ile Arg Lys 
                165                 170                 175     


Tyr Ser Pro Lys Arg Pro Phe Phe Ile Ala Leu Gly His Asp Glu Glu 
            180                 185                 190         


Val Ser Gly Thr Lys Gly Ala Gln Gln Ile Ser Ala Leu Leu Gln Thr 
        195                 200                 205             


Arg Gly Val Gln Leu Ala Phe Leu Val Asp Glu Gly Ser Phe Ile Leu 
    210                 215                 220                 


Glu Asp Phe Ile Pro Asn Leu Lys Lys Pro Phe Ala Met Ile Ser Val 
225                 230                 235                 240 


Thr Glu Lys Gly Ala Leu Asp Leu Met Leu Gln Val Asn Met Thr Pro 
                245                 250                 255     


Gly His Ser Ser Ala Pro Pro Lys Glu Thr Ser Ile Gly Ile Leu Ser 
            260                 265                 270         


Ala Ala Val Ser Arg Leu Glu Gln Thr Pro Met Pro Asn Met Phe Gly 
        275                 280                 285             


Asn Gly Pro Leu Lys Lys Thr Leu Lys Leu Leu Ala Asn Glu Phe Ser 
    290                 295                 300                 


Phe Pro Thr Asn Ile Ile Leu Gly Asn Leu Trp Leu Phe Arg Pro Ile 
305                 310                 315                 320 


Val Ser Arg Val Met Glu Arg Asn Pro Ile Thr Asn Ala Leu Val Arg 
                325                 330                 335     


Thr Thr Thr Ala Leu Thr Met Phe Asn Ala Gly Ile Lys Val Asn Val 
            340                 345                 350         


Ile Pro Pro Leu Ala Gln Ala Thr Val Asn Phe Arg Ile His Pro Ser 
        355                 360                 365             


Gln Thr Val His Glu Val Val Glu Leu Val Gln Asn Ile Val Ala Asp 
    370                 375                 380                 


Asp Arg Val Gln Leu His Val Leu Arg Ser Phe Glu Pro Leu Pro Val 
385                 390                 395                 400 


Ser Pro Ser Asp Asp Gln Ala Met Gly Tyr Gln Leu Leu Gln Gln Thr 
                405                 410                 415     


Ile Gln Ser Val Phe Pro Glu Val Lys Ile Ile Val Pro Gly Ile Cys 
            420                 425                 430         


Ile Gly Asn Thr Asp Thr Arg His Tyr Val Asn Leu Thr Asn Gly Leu 
        435                 440                 445             


Tyr Arg Phe Asn Pro Val Phe Leu Lys Pro Gln Asp Phe Ser Ser Val 
    450                 455                 460                 


His Gly Ile Asn Glu Lys Ile Ser Val Glu Ser Tyr Gln Asn Gln Val 
465                 470                 475                 480 


Lys Phe Ile Phe Glu Leu Ile Gln Asn Ala Asp Thr Tyr Ser Lys Pro 
                485                 490                 495     


Val Pro His Gln His Glu Leu 
            500             


<210>  11
<211>  1554
<212>  DNA
<213>  Gallus gallus

<400>  11
atggcgggtg ggtgcgggcg gcggcgggta gttgtgtgcg cggtggcgtt ggggctgagc       60

gcggcggtgc tggctctaac ggccgtagtg ttgctccgcg cctacgtgct gcgctccccg      120

gccatcccgc ggctgtgggc gcggcgcggg agcaccgccg ctttcagtgc cagcgagagg      180

cgggagctga aggaagcgct gcgaggtgct gttcgaatcc cgactgtttc cttgtcttcg      240

gaggacttca acacaactgc catggcagag tttggggatt acattcggaa agccttccca      300

gctgtctttt cttccaagtt cattcaacat gaaatcattg gggagtacag ccacctcttc      360

accgttcagg gttctgactc tgaaatgatg ccctacatgc tgctcgcaca catggatgtt      420

gtgcccgctc cccctgaggg ctgggatttc cctcctttct cagctgcaga gcatgaaggt      480

ttcatctatg gacgaggaac gctggacaac aaaaactctg ccattggcat tctgcaagct      540

ctagaattct tactgagaag aaattacaga ccccgcaggt ctttctatgt tggcattggc      600

catgatgaag aggtgtttgg tcagaaggga gcactgaaga ttgcagctct gctggaatcc      660

agaggagtga aactctcctt cttgctggat gagggaagtg ctatactgga tggcatcatt      720

gcaggtgtga agaagccagt agctctaatt gctgtgacag agaagggttt aatgacactg      780

aacttcaccg tggaaaaaga gccaggacat tcatccttcc ctccaaaaga gacaagtatt      840

ggcattcttg caacagcagt gtccagactg gagcagaatc ccatgcgcag tctgtttggc      900

cgtggtccgg aactcatgac tatggagcac cttgcatcag agttcaattt tcctctcaat      960

ctcatcatga gcaatctctg gctgttttcg cctattgtca gcagagttct tgcctggaaa     1020

ccttccacta atgccttgat tcgaactact acagcagtca caatgtttaa cgcaggaatc     1080

aagttcaatg tcatcccacc atctgcaaga gcaactgtga acttccggat ccactctgga     1140

gagaaggcca aagaggtgct agagacagtt agaaacacag ttgcggatga cagagtgaag     1200

attgatgtca tagaggccct tgacccccta cccatcagcc catgggatga ccagaccttt     1260

ggagtccatg tttttcaaag aaccattctg gatactttcc caaatgttga cagtgtagtc     1320

ccaggcacgt gtattggaaa cacagacagc aggcatttca ctaacgtcac aaatgccatt     1380

tatcgattta acccagtgct cttgaagtca gatgatcttc ccaggatcca tgggttgaat     1440

gagagaatct cggttgagag ttatgagaaa caggtcgagt ttctctttca gctcattaag     1500

aactgtgatg ttgacaagct tccggagcct cacgcaaact ctcatgagct gtga           1554


<210>  12
<211>  517
<212>  PRT
<213>  Gallus gallus

<400>  12

Met Ala Gly Gly Cys Gly Arg Arg Arg Val Val Val Cys Ala Val Ala 
1               5                   10                  15      


Leu Gly Leu Ser Ala Ala Val Leu Ala Leu Thr Ala Val Val Leu Leu 
            20                  25                  30          


Arg Ala Tyr Val Leu Arg Ser Pro Ala Ile Pro Arg Leu Trp Ala Arg 
        35                  40                  45              


Arg Gly Ser Thr Ala Ala Phe Ser Ala Ser Glu Arg Arg Glu Leu Lys 
    50                  55                  60                  


Glu Ala Leu Arg Gly Ala Val Arg Ile Pro Thr Val Ser Leu Ser Ser 
65                  70                  75                  80  


Glu Asp Phe Asn Thr Thr Ala Met Ala Glu Phe Gly Asp Tyr Ile Arg 
                85                  90                  95      


Lys Ala Phe Pro Ala Val Phe Ser Ser Lys Phe Ile Gln His Glu Ile 
            100                 105                 110         


Ile Gly Glu Tyr Ser His Leu Phe Thr Val Gln Gly Ser Asp Ser Glu 
        115                 120                 125             


Met Met Pro Tyr Met Leu Leu Ala His Met Asp Val Val Pro Ala Pro 
    130                 135                 140                 


Pro Glu Gly Trp Asp Phe Pro Pro Phe Ser Ala Ala Glu His Glu Gly 
145                 150                 155                 160 


Phe Ile Tyr Gly Arg Gly Thr Leu Asp Asn Lys Asn Ser Ala Ile Gly 
                165                 170                 175     


Ile Leu Gln Ala Leu Glu Phe Leu Leu Arg Arg Asn Tyr Arg Pro Arg 
            180                 185                 190         


Arg Ser Phe Tyr Val Gly Ile Gly His Asp Glu Glu Val Phe Gly Gln 
        195                 200                 205             


Lys Gly Ala Leu Lys Ile Ala Ala Leu Leu Glu Ser Arg Gly Val Lys 
    210                 215                 220                 


Leu Ser Phe Leu Leu Asp Glu Gly Ser Ala Ile Leu Asp Gly Ile Ile 
225                 230                 235                 240 


Ala Gly Val Lys Lys Pro Val Ala Leu Ile Ala Val Thr Glu Lys Gly 
                245                 250                 255     


Leu Met Thr Leu Asn Phe Thr Val Glu Lys Glu Pro Gly His Ser Ser 
            260                 265                 270         


Phe Pro Pro Lys Glu Thr Ser Ile Gly Ile Leu Ala Thr Ala Val Ser 
        275                 280                 285             


Arg Leu Glu Gln Asn Pro Met Arg Ser Leu Phe Gly Arg Gly Pro Glu 
    290                 295                 300                 


Leu Met Thr Met Glu His Leu Ala Ser Glu Phe Asn Phe Pro Leu Asn 
305                 310                 315                 320 


Leu Ile Met Ser Asn Leu Trp Leu Phe Ser Pro Ile Val Ser Arg Val 
                325                 330                 335     


Leu Ala Trp Lys Pro Ser Thr Asn Ala Leu Ile Arg Thr Thr Thr Ala 
            340                 345                 350         


Val Thr Met Phe Asn Ala Gly Ile Lys Phe Asn Val Ile Pro Pro Ser 
        355                 360                 365             


Ala Arg Ala Thr Val Asn Phe Arg Ile His Ser Gly Glu Lys Ala Lys 
    370                 375                 380                 


Glu Val Leu Glu Thr Val Arg Asn Thr Val Ala Asp Asp Arg Val Lys 
385                 390                 395                 400 


Ile Asp Val Ile Glu Ala Leu Asp Pro Leu Pro Ile Ser Pro Trp Asp 
                405                 410                 415     


Asp Gln Thr Phe Gly Val His Val Phe Gln Arg Thr Ile Leu Asp Thr 
            420                 425                 430         


Phe Pro Asn Val Asp Ser Val Val Pro Gly Thr Cys Ile Gly Asn Thr 
        435                 440                 445             


Asp Ser Arg His Phe Thr Asn Val Thr Asn Ala Ile Tyr Arg Phe Asn 
    450                 455                 460                 


Pro Val Leu Leu Lys Ser Asp Asp Leu Pro Arg Ile His Gly Leu Asn 
465                 470                 475                 480 


Glu Arg Ile Ser Val Glu Ser Tyr Glu Lys Gln Val Glu Phe Leu Phe 
                485                 490                 495     


Gln Leu Ile Lys Asn Cys Asp Val Asp Lys Leu Pro Glu Pro His Ala 
            500                 505                 510         


Asn Ser His Glu Leu 
        515         


<210>  13
<211>  1539
<212>  DNA
<213>  Xenopus laevis

<400>  13
atggcagtat ctcgctggaa ggctgtgggc agcactctgc ttgctgcgtt tttagtgggg       60

ctggtagtgc ttatagccgt tttgctcatc agaacttaca ctttgcctac agcggtcagg      120

aagtggaata ggaatgaaag tctgatcact gaacttgctg agaaagagag aaagcagctg      180

gtggaggcac tgaaaggtgc cattcgcatt cccactgtct ccttttcaga agaggagcag      240

aataccacag cactcagaga gtttggagaa tacatacaga aagtcttccc tcaggttttc      300

tcctccagtc taatccagca tgaggttttg ggaggttaca gtcacctttt taaagtacaa      360

ggctctgacc acaatctact tccatacatg ttactggctc acattgatgt tgtaccagct      420

ccaccagagt cctgggaggt gccacctttc tctggcgagg aacgagatgg ttatatctat      480

ggaagaggaa ccctagatga caagaactgt gttattggaa ttcttcagtc acttgaattc      540

ctcctgaaaa gaggtcacaa acctcgccga tctttctaca taggccttgg acatgatgaa      600

gagatatctg gccacaaagg tgcccagaag attgtggaga agttgcagtc tcaaggagtt      660

aagctggcat ttgttttaga tgagggcttg gcagtcctag atggggttat tcaaggcatt      720

agtcaacctg tcgcactggt tggtaccaca gaaaaaggat cagttacctt ggacctcaca      780

gtaaatcgtt tacctggtca ttcttctatg ccgccgtctg aaaccagcat tgggatccta      840

gctgcagctg tgtctagact agagcagaat atgatgccta atatgtttgg aaatggtcca      900

gaacaagaca tgtttgaaca tctttctaca aagtttgact ttccactaaa tattatcatg      960

gcaaatctat ggctattttc acccatttta agcagaattc tggagctgtc gccttccacc     1020

aatgccatag tacggacaac aactgctctt accatcttca aagcagggat caagtcaaat     1080

gtgatcccac ctacagccac agcaactgtt aatttccggc ttcaccctgc acagacggta     1140

caagaggtcc tggatattgt tcagaacact ataaaggatg aaagagtgga gctatctgtc     1200

ttgaattcat tcgatccttt accagtcagt ccgaatgata tgagtttggg gtaccatatt     1260

cttcagcgta ccattcatga tgtcttttca ggacctccag ttgccccagg tgtttgtgtt     1320

ggcaatacag acagccgcca ttttgtcaac ttgaccaaca gtatctacag atttagccct     1380

gtggtgctca aaaaggagga tgtggatagg attcatgggt tgaatgagcg catttctaaa     1440

gaggcaattg aactccttgt ccagttctac atccagctga ttcaaaattc agatacagat     1500

aacatccctc caccacatct tgacacccat gagctttaa                            1539


<210>  14
<211>  512
<212>  PRT
<213>  Xenopus laevis

<400>  14

Met Ala Val Ser Arg Trp Lys Ala Val Gly Ser Thr Leu Leu Ala Ala 
1               5                   10                  15      


Phe Leu Val Gly Leu Val Val Leu Ile Ala Val Leu Leu Ile Arg Thr 
            20                  25                  30          


Tyr Thr Leu Pro Thr Ala Val Arg Lys Trp Asn Arg Asn Glu Ser Leu 
        35                  40                  45              


Ile Thr Glu Leu Ala Glu Lys Glu Arg Lys Gln Leu Val Glu Ala Leu 
    50                  55                  60                  


Lys Gly Ala Ile Arg Ile Pro Thr Val Ser Phe Ser Glu Glu Glu Gln 
65                  70                  75                  80  


Asn Thr Thr Ala Leu Arg Glu Phe Gly Glu Tyr Ile Gln Lys Val Phe 
                85                  90                  95      


Pro Gln Val Phe Ser Ser Ser Leu Ile Gln His Glu Val Leu Gly Gly 
            100                 105                 110         


Tyr Ser His Leu Phe Lys Val Gln Gly Ser Asp His Asn Leu Leu Pro 
        115                 120                 125             


Tyr Met Leu Leu Ala His Ile Asp Val Val Pro Ala Pro Pro Glu Ser 
    130                 135                 140                 


Trp Glu Val Pro Pro Phe Ser Gly Glu Glu Arg Asp Gly Tyr Ile Tyr 
145                 150                 155                 160 


Gly Arg Gly Thr Leu Asp Asp Lys Asn Cys Val Ile Gly Ile Leu Gln 
                165                 170                 175     


Ser Leu Glu Phe Leu Leu Lys Arg Gly His Lys Pro Arg Arg Ser Phe 
            180                 185                 190         


Tyr Ile Gly Leu Gly His Asp Glu Glu Ile Ser Gly His Lys Gly Ala 
        195                 200                 205             


Gln Lys Ile Val Glu Lys Leu Gln Ser Gln Gly Val Lys Leu Ala Phe 
    210                 215                 220                 


Val Leu Asp Glu Gly Leu Ala Val Leu Asp Gly Val Ile Gln Gly Ile 
225                 230                 235                 240 


Ser Gln Pro Val Ala Leu Val Gly Thr Thr Glu Lys Gly Ser Val Thr 
                245                 250                 255     


Leu Asp Leu Thr Val Asn Arg Leu Pro Gly His Ser Ser Met Pro Pro 
            260                 265                 270         


Ser Glu Thr Ser Ile Gly Ile Leu Ala Ala Ala Val Ser Arg Leu Glu 
        275                 280                 285             


Gln Asn Met Met Pro Asn Met Phe Gly Asn Gly Pro Glu Gln Asp Met 
    290                 295                 300                 


Phe Glu His Leu Ser Thr Lys Phe Asp Phe Pro Leu Asn Ile Ile Met 
305                 310                 315                 320 


Ala Asn Leu Trp Leu Phe Ser Pro Ile Leu Ser Arg Ile Leu Glu Leu 
                325                 330                 335     


Ser Pro Ser Thr Asn Ala Ile Val Arg Thr Thr Thr Ala Leu Thr Ile 
            340                 345                 350         


Phe Lys Ala Gly Ile Lys Ser Asn Val Ile Pro Pro Thr Ala Thr Ala 
        355                 360                 365             


Thr Val Asn Phe Arg Leu His Pro Ala Gln Thr Val Gln Glu Val Leu 
    370                 375                 380                 


Asp Ile Val Gln Asn Thr Ile Lys Asp Glu Arg Val Glu Leu Ser Val 
385                 390                 395                 400 


Leu Asn Ser Phe Asp Pro Leu Pro Val Ser Pro Asn Asp Met Ser Leu 
                405                 410                 415     


Gly Tyr His Ile Leu Gln Arg Thr Ile His Asp Val Phe Ser Gly Pro 
            420                 425                 430         


Pro Val Ala Pro Gly Val Cys Val Gly Asn Thr Asp Ser Arg His Phe 
        435                 440                 445             


Val Asn Leu Thr Asn Ser Ile Tyr Arg Phe Ser Pro Val Val Leu Lys 
    450                 455                 460                 


Lys Glu Asp Val Asp Arg Ile His Gly Leu Asn Glu Arg Ile Ser Lys 
465                 470                 475                 480 


Glu Ala Ile Glu Leu Leu Val Gln Phe Tyr Ile Gln Leu Ile Gln Asn 
                485                 490                 495     


Ser Asp Thr Asp Asn Ile Pro Pro Pro His Leu Asp Thr His Glu Leu 
            500                 505                 510         


<210>  15
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  15
acccttcacc aatgactcct atg                                               23


<210>  16
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  16
tgactgcagc aaatcgcttg g                                                 21


<210>  17
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  17
aaggtgaaga gcatcataac cct                                               23


<210>  18
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  18
tcacgccttt cataacacat tcc                                               23


<210>  19
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  19
actgccacac ctccagtcat t                                                 21


<210>  20
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  20
ctttgcctca ctcaggattg g                                                 21


<210>  21
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  21
ccctgccatt gttaagacc                                                    19


<210>  22
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  22
tgctgctgtt cctgttttc                                                    19


<210>  23
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  23
gccgactaaa tcaagcaaca                                                   20


<210>  24
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  24
caatgggcat aaagctatgg                                                   20


<210>  25
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  25
gcacatggga gtgttgtga                                                    19


<210>  26
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  26
ccttctcctt ctccttcagc                                                   20


<210>  27
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  27
caagagcatc ccaggctt                                                     18


<210>  28
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  28
gcacttccat ccacacactc                                                   20


<210>  29
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  29
tgaggagacc tatgaggtat ttgc                                              24


<210>  30
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  30
tcatcaaagt agccagaacg ga                                                22


<210>  31
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  31
gcatggtggc tggtgatgag                                                   20


<210>  32
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  32
aaactgcccg tgagtaatct tg                                                22


<210>  33
<211>  38
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  33
gcaggaacca catcaatggc agccatcagc atgtaggg                               38


<210>  34
<211>  38
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  34
ccctacatgc tgatggctgc cattgatgtg gttcctgc                               38


<210>  35
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  35
ggggcaggaa ccacagcaat gtgagccatc a                                      31


<210>  36
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  36
tgatggctca cattgctgtg gttcctgccc c                                      31


<210>  37
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  37
aaactttctc attgattcca gcgacaccac tgaagtcctg ag                          42


<210>  38
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  38
ctcaggactt cagtggtgtc gctggaatca atgagaaagt tt                          42


<210>  39
<211>  132
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic mouse PM20D1
       knockout nucleic acid sequence"

<400>  39
atggctgagc tacttgctag cttgcccgcc tgggcagctg tgctccttct ctttttcgct       60

acggtctccg gatccactgg ccctagaagc agggaaaatc ggggggcgtc ccggatccct      120

tcccagtagg ag                                                          132