                         SEQUENCE LISTING

<110>  Vora, Kalpit A.
       Cox, Kara S.
       Tang, Aimin
       Chen, Zhifeng
       DiStefano, Daniel
       Zhang, Lan
       Su, Hua-Poo
 
<120>  ANTIBODY NEUTRALIZING HUMAN RESPIRATORY SYNCYTIAL 
       VIRUS

<130>  24158

<150>  US 62/247841
<151>  2015-10-29

<150>  US 62/367359
<151>  2016-07-27

<160>  26    

<170>  PatentIn version 3.5

<210>  1
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  1

Asp Ser Ala Met Ser 
1               5   


<210>  2
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  2

Phe Ile Lys Ser Lys Thr Tyr Gly Gly Thr Lys Glu Tyr Ala Ala Ser 
1               5                   10                  15      


Val Lys Gly 
            


<210>  3
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  3

Gly Ala Pro Tyr Gly Gly Asn Ser Asp Tyr Tyr Tyr Gly Leu Asp Val 
1               5                   10                  15      


<210>  4
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  4

Arg Thr Ser Gln Asp Val Arg Gly Ala Leu Ala 
1               5                   10      


<210>  5
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  5

Asp Ala Ser Ser Leu Glu Thr 
1               5           


<210>  6
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  6

Gln Gln Phe Leu Asp Phe Pro Phe Thr 
1               5                   


<210>  7
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RB-1 heavy chain with amino acid substitution

<400>  7

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Arg Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Val Ser Gly Phe Ser Phe Asp Asp Ser 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Ser Phe Ile Lys Ser Lys Thr Tyr Gly Gly Thr Lys Glu Tyr Ala Ala 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Ile 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Thr Arg Gly Ala Pro Tyr Gly Gly Asn Ser Asp Tyr Tyr Tyr 
            100                 105                 110         


Gly Leu Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125         


<210>  8
<211>  109
<212>  PRT
<213>  Homo sapiens

<400>  8

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Thr Ser Gln Asp Val Arg Gly Ala 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Phe Asp Ala Ser Ser Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Val Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Ala Tyr Tyr Cys Gln Gln Phe Leu Asp Phe Pro Phe 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg Thr 
            100                 105                 


<210>  9
<211>  127
<212>  PRT
<213>  Homo sapiens

<400>  9

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Arg Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Val Ser Gly Phe Ser Phe Asp Asp Ser 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Ser Phe Ile Lys Ser Lys Thr Tyr Gly Gly Thr Lys Glu Tyr Ala Ala 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Ile 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Thr Arg Gly Ala Pro Tyr Gly Gly Asn Ser Asp Tyr Tyr Tyr 
            100                 105                 110         


Gly Leu Asp Val Trp Gly Gln Gly Thr Thr Val Ile Val Ser Ser 
        115                 120                 125         


<210>  10
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Leader sequence

<400>  10

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser 
            


<210>  11
<211>  146
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RBI VH amino acid substituted with leader

<400>  11

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Arg 
            20                  25                  30          


Pro Gly Arg Ser Leu Arg Leu Ser Cys Thr Val Ser Gly Phe Ser Phe 
        35                  40                  45              


Asp Asp Ser Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Ile Ser Phe Ile Lys Ser Lys Thr Tyr Gly Gly Thr Lys Glu 
65                  70                  75                  80  


Tyr Ala Ala Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser 
                85                  90                  95      


Lys Asn Ile Ala Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Thr Arg Gly Ala Pro Tyr Gly Gly Asn Ser Asp 
        115                 120                 125             


Tyr Tyr Tyr Gly Leu Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val 
    130                 135                 140                 


Ser Ser 
145     


<210>  12
<211>  128
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RB-1 VL and leader

<400>  12

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
            20                  25                  30          


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Thr Ser Gln Asp Val 
        35                  40                  45              


Arg Gly Ala Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 
    50                  55                  60                  


Leu Leu Ile Phe Asp Ala Ser Ser Leu Glu Thr Gly Val Pro Ser Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Gly Ser Gly Thr Val Phe Thr Leu Thr Ile Ser Ser 
                85                  90                  95      


Leu Gln Pro Glu Asp Phe Ala Ala Tyr Tyr Cys Gln Gln Phe Leu Asp 
            100                 105                 110         


Phe Pro Phe Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg Thr 
        115                 120                 125             


<210>  13
<211>  330
<212>  PRT
<213>  Homo sapiens

<400>  13

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  14
<211>  105
<212>  PRT
<213>  Homo sapiens

<400>  14

Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu 
1               5                   10                  15      


Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro 
            20                  25                  30          


Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly 
        35                  40                  45              


Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr 
    50                  55                  60                  


Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His 
65                  70                  75                  80  


Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val 
                85                  90                  95      


Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105 


<210>  15
<211>  381
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RB-1 with amino acid substitution

<400>  15
gaggtgcagc tggtggagtc tgggggaggc ttggtacggc cagggcggtc cctgagactc       60

tcctgcacag tttctggatt cagctttgac gactctgcta tgagctgggt ccgccaggct      120

ccagggaagg ggctggaatg gataagtttc attaaaagta aaacttatgg tgggacaaaa      180

gaatacgccg cgtctgtgaa aggcaggttc accatctcaa gagatgattc caaaaacatc      240

gcctatctgc aaatgaacag cctgaaaacc gaggacacag ccgtgtatta ttgtactaga      300

ggggcgcctt acggcggtaa ctccgattac tactacggtt tggacgtctg gggccaaggg      360

accacggtca ctgtctcctc a                                                381


<210>  16
<211>  327
<212>  DNA
<213>  Homo sapiens

<400>  16
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc ggacaagtca ggacgttaga ggtgctttag cctggtatca acagaaacca      120

gggaaagctc ctaaactcct gatctttgat gcctccagtt tggagactgg ggtcccatca      180

aggttcagcg gcagtggatc tgggacagtt ttcactctca ccatcagcag cctgcagcct      240

gaagattttg cagcttatta ctgtcagcag tttcttgatt tccctttcac cttcggccag      300

gggacacgac tggaaatcaa acgtacg                                          327


<210>  17
<211>  381
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RB-1 VH codon optimized

<400>  17
gaggtgcagc tggtcgagag cggggggggg ctggtgcggc ctggcaggtc tctgagactg       60

agctgcaccg tgagcggctt ctcctttgac gattctgcca tgagctgggt gcggcaggct      120

ccaggcaagg gactggagtg gatctccttc atcaagtcta agacctacgg cggcacaaag      180

gagtacgccg cttccgtgaa gggccggttt accatcagca gggacgattc caagaacatc      240

gcctatctgc agatgaacag cctgaagacc gaggacacag ccgtgtacta ttgcacaaga      300

ggagctcctt acggaggcaa cagcgactac tattacggac tggacgtgtg gggacaggga      360

accacagtga ccgtgagctc c                                                381


<210>  18
<211>  327
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RB-1 VL codon optimized

<400>  18
gacattcaga tgactcagtc cccttcaagt ctgagcgcct ccgtgggcga cagagtgacc       60

atcacatgcc ggaccagcca ggatgtgcgg ggcgccctgg cttggtacca gcagaagcca      120

ggcaaggccc ccaagctgct gatctttgac gctagctccc tggagaccgg cgtgccctcc      180

aggttttctg gcagcggctc cggcacagtg ttcaccctga caatctctag cctgcagcct      240

gaggactttg ccgcttacta ttgccagcag ttcctggatt tccccttcac cttcggccaa      300

ggcacacggc tggagatcaa gaggacc                                          327


<210>  19
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Leader sequence heavy chain

<400>  19
atgggttggt cctgtattat cctgttcctg gtcgccactg ctactggggt ccactca          57


<210>  20
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Leader sequence light chain

<400>  20
atgggctggt cctgtattat cctgttcctg gtggcaaccg caactggtgt gcatagc          57


<210>  21
<211>  990
<212>  DNA
<213>  Homo sapiens

<400>  21
gcctctacaa agggccctag cgtgttccca ctggctccct cttccaagtc taccagcgga       60

ggaacagccg ctctgggatg tctggtgaag gattacttcc cagagcccgt gaccgtgtcc      120

tggaactctg gcgccctgac cagcggagtg cacacatttc cagctgtgct gcagtcctct      180

ggcctgtatt ccctgagctc cgtggtgacc gtgccctcta gctccctggg cacccagaca      240

tacatctgta acgtgaatca caagccaagc aatacaaagg tggacaagaa ggtcgagccc      300

aagtcctgtg ataagaccca cacatgcccc ccttgtcctg ctccagagct gctgggagga      360

cctagcgtgt tcctgtttcc acccaagcct aaggacaccc tgatgatctc taggaccccc      420

gaggtgacat gcgtggtggt ggacgtgagc cacgaggatc ctgaggtgaa gtttaactgg      480

tacgtcgatg gcgtggaggt gcacaatgcc aagacaaagc ccagagagga gcagtataac      540

tccacctacc gggtggtgtc tgtgctgaca gtgctgcacc aggactggct gaacggcaag      600

gagtacaagt gcaaggtgtc caataaggcc ctgcccgctc ctatcgagaa gaccatctct      660

aaggccaagg gccagcctag ggagccacag gtgtatacac tgcctccatc cagagacgag      720

ctgaccaaga accaggtgtc tctgacatgt ctggtgaagg gcttctaccc ttctgatatc      780

gccgtggagt gggagagcaa tggccagcca gagaacaatt ataagaccac accccctgtg      840

ctggacagcg atggctcctt ctttctgtac agcaagctga ccgtggataa gtcccggtgg      900

cagcagggca acgtgttcag ctgttctgtg atgcacgaag ccctgcacaa tcactacact      960

cagaagagcc tgtccctgtc acctggtaaa                                       990


<210>  22
<211>  315
<212>  DNA
<213>  Homo sapiens

<400>  22
gtggccgctc cctccgtgtt tatcttcccc ccttctgacg agcagctgaa gtctggcaca       60

gctagcgtgg tgtgcctgct gaacaatttc taccctcggg aggccaaggt gcagtggaag      120

gtggataacg ctctgcagtc tggcaatagc caggagtccg tgaccgagca ggactctaag      180

gatagcacat attccctgtc ctctaccctg acactgtcta aggccgatta cgagaagcac      240

aaggtgtatg cttgtgaagt cacccaccag gggctgagtt caccagtcac caagtcattc      300

aatcggggcg agtgc                                                       315


<210>  23
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RB1+YTE HEAVY CHAIN

<400>  23

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Arg Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Val Ser Gly Phe Ser Phe Asp Asp Ser 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Ser Phe Ile Lys Ser Lys Thr Tyr Gly Gly Thr Lys Glu Tyr Ala Ala 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Ile 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Thr Arg Gly Ala Pro Tyr Gly Gly Asn Ser Asp Tyr Tyr Tyr 
            100                 105                 110         


Gly Leu Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala 
        115                 120                 125             


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
    130                 135                 140                 


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
145                 150                 155                 160 


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
                165                 170                 175     


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
            180                 185                 190         


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
        195                 200                 205             


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys 
    210                 215                 220                 


Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
225                 230                 235                 240 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                245                 250                 255     


Pro Lys Asp Thr Leu Tyr Ile Thr Arg Glu Pro Glu Val Thr Cys Val 
            260                 265                 270         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        275                 280                 285             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    290                 295                 300                 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
305                 310                 315                 320 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                325                 330                 335     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            340                 345                 350         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
        355                 360                 365             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    370                 375                 380                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
385                 390                 395                 400 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                405                 410                 415     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            420                 425                 430         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        435                 440                 445             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455         


<210>  24
<211>  1374
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NUCLEIC ACID ENCODING RB1+YTE HEAVY CHAIN (CODON OPTIMIZED)

<400>  24
gaggtgcagc tggtggaatc cggcggcgga ctggtcagac ctggcagatc cctgaggctc       60

agctgtaccg tgagcggctt cagcttcgac gactccgcca tgagctgggt gagacaggcc      120

cctggcaagg gcctggagtg gatcagcttc atcaagagca aaacctatgg cggaaccaag      180

gaatacgccg cctccgtgaa gggcaggttc accatttcca gggacgacag caagaacatc      240

gcttacctcc agatgaactc cctcaagacc gaggataccg ccgtgtatta ttgcaccaga      300

ggcgccccct acggcggcaa ttccgactat tactacggcc tggatgtctg gggccaaggc      360

acaacagtga ccgtgagctc cgctagcacc aagggaccca gcgtgttccc cctggccccc      420

agcagcaaga gcacaagcgg aggaacagcc gccctcggct gtctggtgaa agactacttc      480

cccgagcctg tgacagtcag ctggaatagc ggcgctctga ccagcggcgt ccacaccttt      540

cccgctgtcc tgcagagctc cggcctgtac agcctgtcct ccgtggtcac agtgccctcc      600

tccagcctgg gcacacaaac ctacatctgt aacgtgaacc acaagcccag caacaccaag      660

gtggacaaga aggtcgaacc caaatcctgt gacaagaccc acacatgccc cccctgcccc      720

gcccctgagc tgctgggcgg cccttccgtg ttcctgttcc ctcccaagcc caaggatacc      780

ctgtatatca ccagagaacc cgaggtgacc tgtgtggtgg tcgacgtcag ccacgaagat      840

cctgaggtca agttcaactg gtatgtggac ggcgtggagg tgcataacgc caaaaccaag      900

cccagggagg aacagtataa cagcacctac agggtggtgt ccgtcctgac cgtgctgcac      960

caggactggc tgaacggaaa ggagtacaaa tgtaaggtca gcaacaaagc cctgcccgct     1020

cctatcgaaa agaccatctc caaggccaaa ggccagccca gagaacccca ggtgtacacc     1080

ctgcccccta gcagagacga gctgaccaaa aaccaggtct ccctgacctg cctggtgaaa     1140

ggcttctacc ccagcgatat cgccgtggaa tgggaaagca acggccagcc tgagaacaac     1200

tacaagacca cccctcccgt gctcgacagc gatggcagct tctttctgta cagcaagctg     1260

accgtggaca agagcaggtg gcaacaaggc aacgtgttct cctgctccgt gatgcacgag     1320

gctctgcaca accactatac ccagaagtcc ctgagcctca gccccggaaa atga           1374


<210>  25
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RB1+YTE LIGHT CHAIN

<400>  25

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Thr Ser Gln Asp Val Arg Gly Ala 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Phe Asp Ala Ser Ser Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Val Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Ala Tyr Tyr Cys Gln Gln Phe Leu Asp Phe Pro Phe 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  26
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NUCLEIC ACID ENCODING RB1+YTE LIGHT CHAIN

<400>  26
gacattcaga tgactcagtc cccttcaagt ctgagcgcct ccgtgggcga cagagtgacc       60

atcacatgcc ggaccagcca ggatgtgcgg ggcgccctgg cttggtacca gcagaagcca      120

ggcaaggccc ccaagctgct gatctttgac gctagctccc tggagaccgg cgtgccctcc      180

aggttttctg gcagcggctc cggcacagtg ttcaccctga caatctctag cctgcagcct      240

gaggactttg ccgcttacta ttgccagcag ttcctggatt tccccttcac cttcggccaa      300

ggcacacggc tggagatcaa gaggaccgtg gccgctccct ccgtgtttat cttcccccct      360

tctgacgagc agctgaagtc tggcacagct agcgtggtgt gcctgctgaa caatttctac      420

cctcgggagg ccaaggtgca gtggaaggtg gataacgctc tgcagtctgg caatagccag      480

gagtccgtga ccgagcagga ctctaaggat agcacatatt ccctgtcctc taccctgaca      540

ctgtctaagg ccgattacga gaagcacaag gtgtatgctt gtgaagtcac ccaccagggg      600

ctgagttcac cagtcaccaa gtcattcaat cggggcgagt gc                         642


