                         SEQUENCE LISTING

<110>  Scholar Rock
 
<120>  PRIMED GROWTH FACTORS AND USES THEREOF

<130>  S1918.70000WO00

<150>  US 62/247,179
<151>  2015-10-27

<160>  11    

<170>  PatentIn version 3.5

<210>  1
<211>  380
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  1

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Phe Ser Gly Val Leu Gly His His His His His His Asn Glu Asn Ser 
            20                  25                  30          


Glu Gln Lys Glu Asn Val Glu Lys Glu Gly Leu Cys Asn Ala Cys Thr 
        35                  40                  45              


Trp Arg Gln Asn Thr Lys Ser Ser Arg Ile Glu Ala Ile Lys Ile Gln 
    50                  55                  60                  


Ile Leu Ser Lys Leu Arg Leu Glu Thr Ala Pro Asn Ile Ser Lys Asp 
65                  70                  75                  80  


Val Ile Arg Gln Leu Leu Pro Lys Ala Pro Pro Leu Arg Glu Leu Ile 
                85                  90                  95      


Asp Gln Tyr Asp Val Gln Arg Asp Asp Ser Ser Asp Gly Ser Leu Glu 
            100                 105                 110         


Asp Asp Asp Tyr His Ala Thr Thr Glu Thr Ile Ile Thr Met Pro Thr 
        115                 120                 125             


Glu Ser Asp Phe Leu Met Gln Val Asp Gly Lys Pro Lys Cys Cys Phe 
    130                 135                 140                 


Phe Lys Phe Ser Ser Lys Ile Gln Tyr Asn Lys Val Val Lys Ala Gln 
145                 150                 155                 160 


Leu Trp Ile Tyr Leu Arg Pro Val Glu Thr Pro Thr Thr Val Phe Val 
                165                 170                 175     


Gln Ile Leu Arg Leu Ile Lys Pro Met Lys Asp Gly Thr Arg Tyr Thr 
            180                 185                 190         


Gly Ile Arg Ser Leu Lys Leu Asp Met Asn Pro Gly Thr Gly Ile Trp 
        195                 200                 205             


Gln Ser Ile Asp Val Lys Thr Val Leu Gln Asn Trp Leu Lys Gln Pro 
    210                 215                 220                 


Glu Ser Asn Leu Gly Ile Glu Ile Lys Ala Leu Asp Glu Asn Gly His 
225                 230                 235                 240 


Asp Leu Ala Val Thr Phe Pro Gly Pro Gly Glu Asp Gly Leu Asn Pro 
                245                 250                 255     


Phe Leu Glu Val Lys Val Thr Asp Thr Pro Lys Arg Ser Arg Arg Asp 
            260                 265                 270         


Phe Gly Leu Asp Cys Asp Glu His Ser Thr Glu Ser Arg Cys Cys Arg 
        275                 280                 285             


Tyr Pro Leu Thr Val Asp Phe Glu Ala Phe Gly Trp Asp Trp Ile Ile 
    290                 295                 300                 


Ala Pro Lys Arg Tyr Lys Ala Asn Tyr Cys Ser Gly Glu Cys Glu Phe 
305                 310                 315                 320 


Val Phe Leu Gln Lys Tyr Pro His Thr His Leu Val His Gln Ala Asn 
                325                 330                 335     


Pro Arg Gly Ser Ala Gly Pro Cys Cys Thr Pro Thr Lys Met Ser Pro 
            340                 345                 350         


Ile Asn Met Leu Tyr Phe Asn Gly Lys Glu Gln Ile Ile Tyr Gly Lys 
        355                 360                 365             


Ile Pro Ala Met Val Val Asp Arg Cys Gly Cys Ser 
    370                 375                 380 


<210>  2
<211>  396
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  2

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Phe Ser Gly Val Leu Gly Asp Tyr Lys Asp Asp Asp Asp Lys His His 
            20                  25                  30          


His His His His Leu Glu Val Leu Phe Gln Gly Pro Asn Glu Gly Ser 
        35                  40                  45              


Glu Arg Glu Glu Asn Val Glu Lys Glu Gly Leu Cys Asn Ala Cys Ala 
    50                  55                  60                  


Trp Arg Gln Asn Thr Arg Tyr Ser Arg Ile Glu Ala Ile Lys Ile Gln 
65                  70                  75                  80  


Ile Leu Ser Lys Leu Arg Leu Glu Thr Ala Pro Asn Ile Ser Lys Asp 
                85                  90                  95      


Ala Ile Arg Gln Leu Leu Pro Arg Ala Pro Pro Leu Arg Glu Leu Ile 
            100                 105                 110         


Asp Gln Tyr Asp Val Gln Arg Asp Asp Ser Ser Asp Gly Ser Leu Glu 
        115                 120                 125             


Asp Asp Asp Tyr His Ala Thr Thr Glu Thr Ile Ile Thr Met Pro Thr 
    130                 135                 140                 


Glu Ser Asp Phe Leu Met Gln Ala Asp Gly Lys Pro Lys Cys Cys Phe 
145                 150                 155                 160 


Phe Lys Phe Ser Ser Lys Ile Gln Tyr Asn Lys Val Val Lys Ala Gln 
                165                 170                 175     


Leu Trp Ile Tyr Leu Arg Pro Val Lys Thr Pro Thr Thr Val Phe Val 
            180                 185                 190         


Gln Ile Leu Arg Leu Ile Lys Pro Met Lys Asp Gly Thr Arg Tyr Thr 
        195                 200                 205             


Gly Ile Arg Ser Leu Lys Leu Asp Met Ser Pro Gly Thr Gly Ile Trp 
    210                 215                 220                 


Gln Ser Ile Asp Val Lys Thr Val Leu Gln Asn Trp Leu Lys Gln Pro 
225                 230                 235                 240 


Glu Ser Asn Leu Gly Ile Glu Ile Lys Ala Leu Asp Glu Asn Gly His 
                245                 250                 255     


Asp Leu Ala Val Thr Phe Pro Gly Pro Gly Glu Asp Gly Leu Asn Pro 
            260                 265                 270         


Phe Leu Glu Val Lys Val Thr Asp Thr Pro Lys Arg Ser Arg Arg Asp 
        275                 280                 285             


Phe Gly Leu Asp Cys Asp Glu His Ser Thr Glu Ser Arg Cys Cys Arg 
    290                 295                 300                 


Tyr Pro Leu Thr Val Asp Phe Glu Ala Phe Gly Trp Asp Trp Ile Ile 
305                 310                 315                 320 


Ala Pro Lys Arg Tyr Lys Ala Asn Tyr Cys Ser Gly Glu Cys Glu Phe 
                325                 330                 335     


Val Phe Leu Gln Lys Tyr Pro His Thr His Leu Val His Gln Ala Asn 
            340                 345                 350         


Pro Arg Gly Ser Ala Gly Pro Cys Cys Thr Pro Thr Lys Met Ser Pro 
        355                 360                 365             


Ile Asn Met Leu Tyr Phe Asn Gly Lys Glu Gln Ile Ile Tyr Gly Lys 
    370                 375                 380                 


Ile Pro Ala Met Val Val Asp Arg Cys Gly Cys Ser 
385                 390                 395     


<210>  3
<211>  427
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  3

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Phe Ser Gly Val Leu Gly Asp Tyr Lys Asp Asp Asp Asp Lys His His 
            20                  25                  30          


His His His His Leu Glu Val Leu Phe Gln Gly Pro Ala Glu Gly Pro 
        35                  40                  45              


Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Gly Val Gly 
    50                  55                  60                  


Gly Glu Arg Ser Ser Arg Pro Ala Pro Ser Val Ala Pro Glu Pro Asp 
65                  70                  75                  80  


Gly Cys Pro Val Cys Val Trp Arg Gln His Ser Arg Glu Leu Arg Leu 
                85                  90                  95      


Glu Ser Ile Lys Ser Gln Ile Leu Ser Lys Leu Arg Leu Lys Glu Ala 
            100                 105                 110         


Pro Asn Ile Ser Arg Glu Val Val Lys Gln Leu Leu Pro Lys Ala Pro 
        115                 120                 125             


Pro Leu Gln Gln Ile Leu Asp Leu His Asp Phe Gln Gly Asp Ala Leu 
    130                 135                 140                 


Gln Pro Glu Asp Phe Leu Glu Glu Asp Glu Tyr His Ala Thr Thr Glu 
145                 150                 155                 160 


Thr Val Ile Ser Met Ala Gln Glu Thr Asp Pro Ala Val Gln Thr Asp 
                165                 170                 175     


Gly Ser Pro Leu Cys Cys His Phe His Phe Ser Pro Lys Val Met Phe 
            180                 185                 190         


Thr Lys Val Leu Lys Ala Gln Leu Trp Val Tyr Leu Arg Pro Val Pro 
        195                 200                 205             


Arg Pro Ala Thr Val Tyr Leu Gln Ile Leu Arg Leu Lys Pro Leu Thr 
    210                 215                 220                 


Gly Glu Gly Thr Ala Gly Gly Gly Gly Gly Gly Arg Arg His Ile Arg 
225                 230                 235                 240 


Ile Arg Ser Leu Lys Ile Glu Leu His Ser Arg Ser Gly His Trp Gln 
                245                 250                 255     


Ser Ile Asp Phe Lys Gln Val Leu His Ser Trp Phe Arg Gln Pro Gln 
            260                 265                 270         


Ser Asn Trp Gly Ile Glu Ile Asn Ala Phe Asp Pro Ser Gly Thr Asp 
        275                 280                 285             


Leu Ala Val Thr Ser Leu Gly Pro Gly Ala Glu Gly Leu His Pro Phe 
    290                 295                 300                 


Met Glu Leu Arg Val Leu Glu Asn Thr Lys Arg Ser Arg Arg Asn Leu 
305                 310                 315                 320 


Gly Leu Asp Cys Asp Glu His Ser Ser Glu Ser Arg Cys Cys Arg Tyr 
                325                 330                 335     


Pro Leu Thr Val Asp Phe Glu Ala Phe Gly Trp Asp Trp Ile Ile Ala 
            340                 345                 350         


Pro Lys Arg Tyr Lys Ala Asn Tyr Cys Ser Gly Gln Cys Glu Tyr Met 
        355                 360                 365             


Phe Met Gln Lys Tyr Pro His Thr His Leu Val Gln Gln Ala Asn Pro 
    370                 375                 380                 


Arg Gly Ser Ala Gly Pro Cys Cys Thr Pro Thr Lys Met Ser Pro Ile 
385                 390                 395                 400 


Asn Met Leu Tyr Phe Asn Asp Lys Gln Gln Ile Ile Tyr Gly Lys Ile 
                405                 410                 415     


Pro Gly Met Val Val Asp Arg Cys Gly Cys Ser 
            420                 425         


<210>  4
<211>  425
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  4

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Phe Ser Gly Val Leu Gly Asp Tyr Lys Asp Asp Asp Asp Lys His His 
            20                  25                  30          


His His His His Leu Glu Val Leu Phe Gln Gly Pro Ala Glu Gly Pro 
        35                  40                  45              


Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Gly Val Gly Gly Glu 
    50                  55                  60                  


Arg Ser Ser Arg Pro Ala Pro Ser Ala Pro Pro Glu Pro Asp Gly Cys 
65                  70                  75                  80  


Pro Val Cys Val Trp Arg Gln His Ser Arg Glu Leu Arg Leu Glu Ser 
                85                  90                  95      


Ile Lys Ser Gln Ile Leu Ser Lys Leu Arg Leu Lys Glu Ala Pro Asn 
            100                 105                 110         


Ile Ser Arg Glu Val Val Lys Gln Leu Leu Pro Lys Ala Pro Pro Leu 
        115                 120                 125             


Gln Gln Ile Leu Asp Leu His Asp Phe Gln Gly Asp Ala Leu Gln Pro 
    130                 135                 140                 


Glu Asp Phe Leu Glu Glu Asp Glu Tyr His Ala Thr Thr Glu Thr Val 
145                 150                 155                 160 


Ile Ser Met Ala Gln Glu Thr Asp Pro Ala Val Gln Thr Asp Gly Ser 
                165                 170                 175     


Pro Leu Cys Cys His Phe His Phe Ser Pro Lys Val Met Phe Thr Lys 
            180                 185                 190         


Val Leu Lys Ala Gln Leu Trp Val Tyr Leu Arg Pro Val Pro Arg Pro 
        195                 200                 205             


Ala Thr Val Tyr Leu Gln Ile Leu Arg Leu Lys Pro Leu Thr Gly Glu 
    210                 215                 220                 


Gly Thr Ala Gly Gly Gly Gly Gly Gly Arg Arg His Ile Arg Ile Arg 
225                 230                 235                 240 


Ser Leu Lys Ile Glu Leu His Ser Arg Ser Gly His Trp Gln Ser Ile 
                245                 250                 255     


Asp Phe Lys Gln Val Leu His Ser Trp Phe Arg Gln Pro Gln Ser Asn 
            260                 265                 270         


Trp Gly Ile Glu Ile Asn Ala Phe Asp Pro Ser Gly Thr Asp Leu Ala 
        275                 280                 285             


Val Thr Ser Leu Gly Pro Gly Ala Glu Gly Leu His Pro Phe Met Glu 
    290                 295                 300                 


Leu Arg Val Leu Glu Asn Thr Lys Arg Ser Arg Arg Asn Leu Gly Leu 
305                 310                 315                 320 


Asp Cys Asp Glu His Ser Ser Glu Ser Arg Cys Cys Arg Tyr Pro Leu 
                325                 330                 335     


Thr Val Asp Phe Glu Ala Phe Gly Trp Asp Trp Ile Ile Ala Pro Lys 
            340                 345                 350         


Arg Tyr Lys Ala Asn Tyr Cys Ser Gly Gln Cys Glu Tyr Met Phe Met 
        355                 360                 365             


Gln Lys Tyr Pro His Thr His Leu Val Gln Gln Ala Asn Pro Arg Gly 
    370                 375                 380                 


Ser Ala Gly Pro Cys Cys Thr Pro Thr Lys Met Ser Pro Ile Asn Met 
385                 390                 395                 400 


Leu Tyr Phe Asn Asp Lys Gln Gln Ile Ile Tyr Gly Lys Ile Pro Gly 
                405                 410                 415     


Met Val Val Asp Arg Cys Gly Cys Ser 
            420                 425 


<210>  5
<211>  752
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  5

Met Pro Gly Val Ala Arg Leu Pro Leu Leu Leu Gly Leu Leu Leu Leu 
1               5                   10                  15      


Pro Arg Pro Gly Arg Pro Leu Asp Leu Ala Asp Tyr Thr Tyr Asp Leu 
            20                  25                  30          


Ala Glu Glu Asp Asp Ser Glu Pro Leu Asn Tyr Lys Asp Pro Cys Lys 
        35                  40                  45              


Ala Ala Ala Phe Leu Gly Asp Ile Ala Leu Asp Glu Glu Asp Leu Arg 
    50                  55                  60                  


Ala Phe Gln Val Gln Gln Ala Val Asp Leu Arg Arg His Thr Ala Arg 
65                  70                  75                  80  


Lys Ser Ser Ile Lys Ala Ala Val Pro Gly Asn Thr Ser Thr Pro Ser 
                85                  90                  95      


Cys Gln Ser Thr Asn Gly Gln Pro Gln Arg Gly Ala Cys Gly Arg Trp 
            100                 105                 110         


Arg Gly Arg Ser Arg Ser Arg Arg Ala Ala Thr Ser Arg Pro Glu Arg 
        115                 120                 125             


Val Trp Pro Asp Gly Val Ile Pro Phe Val Ile Gly Gly Asn Phe Thr 
    130                 135                 140                 


Gly Ser Gln Arg Ala Val Phe Arg Gln Ala Met Arg His Trp Glu Lys 
145                 150                 155                 160 


His Thr Cys Val Thr Phe Leu Glu Arg Thr Asp Glu Asp Ser Tyr Ile 
                165                 170                 175     


Val Phe Thr Tyr Arg Pro Cys Gly Cys Cys Ser Tyr Val Gly Arg Arg 
            180                 185                 190         


Gly Gly Gly Pro Gln Ala Ile Ser Ile Gly Lys Asn Cys Asp Lys Phe 
        195                 200                 205             


Gly Ile Val Val His Glu Leu Gly His Val Val Gly Phe Trp His Glu 
    210                 215                 220                 


His Thr Arg Pro Asp Arg Asp Arg His Val Ser Ile Val Arg Glu Asn 
225                 230                 235                 240 


Ile Gln Pro Gly Gln Glu Tyr Asn Phe Leu Lys Met Glu Pro Gln Glu 
                245                 250                 255     


Val Glu Ser Leu Gly Glu Thr Tyr Asp Phe Asp Ser Ile Met His Tyr 
            260                 265                 270         


Ala Arg Asn Thr Phe Ser Arg Gly Ile Phe Leu Asp Thr Ile Val Pro 
        275                 280                 285             


Lys Tyr Glu Val Asn Gly Val Lys Pro Pro Ile Gly Gln Arg Thr Arg 
    290                 295                 300                 


Leu Ser Lys Gly Asp Ile Ala Gln Ala Arg Lys Leu Tyr Lys Cys Pro 
305                 310                 315                 320 


Ala Cys Gly Glu Thr Leu Gln Asp Ser Thr Gly Asn Phe Ser Ser Pro 
                325                 330                 335     


Glu Tyr Pro Asn Gly Tyr Ser Ala His Met His Cys Val Trp Arg Ile 
            340                 345                 350         


Ser Val Thr Pro Gly Glu Lys Ile Ile Leu Asn Phe Thr Ser Leu Asp 
        355                 360                 365             


Leu Tyr Arg Ser Arg Leu Cys Trp Tyr Asp Tyr Val Glu Val Arg Asp 
    370                 375                 380                 


Gly Phe Trp Arg Lys Ala Pro Leu Arg Gly Arg Phe Cys Gly Ser Lys 
385                 390                 395                 400 


Leu Pro Glu Pro Ile Val Ser Thr Asp Ser Arg Leu Trp Val Glu Phe 
                405                 410                 415     


Arg Ser Ser Ser Asn Trp Val Gly Lys Gly Phe Phe Ala Val Tyr Glu 
            420                 425                 430         


Ala Ile Cys Gly Gly Asp Val Lys Lys Asp Tyr Gly His Ile Gln Ser 
        435                 440                 445             


Pro Asn Tyr Pro Asp Asp Tyr Arg Pro Ser Lys Val Cys Ile Trp Arg 
    450                 455                 460                 


Ile Gln Val Ser Glu Gly Phe His Val Gly Leu Thr Phe Gln Ser Phe 
465                 470                 475                 480 


Glu Ile Glu Arg His Asp Ser Cys Ala Tyr Asp Tyr Leu Glu Val Arg 
                485                 490                 495     


Asp Gly His Ser Glu Ser Ser Thr Leu Ile Gly Arg Tyr Cys Gly Tyr 
            500                 505                 510         


Glu Lys Pro Asp Asp Ile Lys Ser Thr Ser Ser Arg Leu Trp Leu Lys 
        515                 520                 525             


Phe Val Ser Asp Gly Ser Ile Asn Lys Ala Gly Phe Ala Val Asn Phe 
    530                 535                 540                 


Phe Lys Glu Val Asp Glu Cys Ser Arg Pro Asn Arg Gly Gly Cys Glu 
545                 550                 555                 560 


Gln Arg Cys Leu Asn Thr Leu Gly Ser Tyr Lys Cys Ser Cys Asp Pro 
                565                 570                 575     


Gly Tyr Glu Leu Ala Pro Asp Lys Arg Arg Cys Glu Ala Ala Cys Gly 
            580                 585                 590         


Gly Phe Leu Thr Lys Leu Asn Gly Ser Ile Thr Ser Pro Gly Trp Pro 
        595                 600                 605             


Lys Glu Tyr Pro Pro Asn Lys Asn Cys Ile Trp Gln Leu Val Ala Pro 
    610                 615                 620                 


Thr Gln Tyr Arg Ile Ser Leu Gln Phe Asp Phe Phe Glu Thr Glu Gly 
625                 630                 635                 640 


Asn Asp Val Cys Lys Tyr Asp Phe Val Glu Val Arg Ser Gly Leu Thr 
                645                 650                 655     


Ala Asp Ser Lys Leu His Gly Lys Phe Cys Gly Ser Glu Lys Pro Glu 
            660                 665                 670         


Val Ile Thr Ser Gln Tyr Asn Asn Met Arg Val Glu Phe Lys Ser Asp 
        675                 680                 685             


Asn Thr Val Ser Lys Lys Gly Phe Lys Ala His Phe Phe Ser Glu Lys 
    690                 695                 700                 


Arg Pro Ala Leu Gln Pro Pro Arg Gly Arg Pro His Gln Leu Lys Phe 
705                 710                 715                 720 


Arg Val Gln Lys Arg Asn Arg Thr Pro Gln Leu Glu Val Leu Phe Gln 
                725                 730                 735     


Gly Pro His His His His His His Asp Tyr Lys Asp Asp Asp Asp Lys 
            740                 745                 750         


<210>  6
<211>  1037
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  6

Met Pro Arg Ala Thr Ala Leu Gly Ala Leu Val Ser Leu Leu Leu Leu 
1               5                   10                  15      


Leu Pro Leu Pro Arg Gly Ala Gly Gly Leu Gly Glu Arg Pro Asp Ala 
            20                  25                  30          


Thr Ala Asp Tyr Ser Glu Leu Asp Gly Glu Glu Gly Thr Glu Gln Gln 
        35                  40                  45              


Leu Glu His Tyr His Asp Pro Cys Lys Ala Ala Val Phe Trp Gly Asp 
    50                  55                  60                  


Ile Ala Leu Asp Glu Asp Asp Leu Lys Leu Phe His Ile Asp Lys Ala 
65                  70                  75                  80  


Arg Asp Trp Thr Lys Gln Thr Val Gly Ala Thr Gly His Ser Thr Gly 
                85                  90                  95      


Gly Leu Glu Glu Gln Ala Ser Glu Ser Ser Pro Asp Thr Thr Ala Met 
            100                 105                 110         


Asp Thr Gly Thr Lys Glu Ala Gly Lys Asp Gly Arg Glu Asn Thr Thr 
        115                 120                 125             


Leu Leu His Ser Pro Gly Thr Leu His Ala Ala Ala Lys Thr Phe Ser 
    130                 135                 140                 


Pro Arg Val Arg Arg Ala Thr Thr Ser Arg Thr Glu Arg Ile Trp Pro 
145                 150                 155                 160 


Gly Gly Val Ile Pro Tyr Val Ile Gly Gly Asn Phe Thr Gly Ser Gln 
                165                 170                 175     


Arg Ala Ile Phe Lys Gln Ala Met Arg His Trp Glu Lys His Thr Cys 
            180                 185                 190         


Val Thr Phe Ile Glu Arg Thr Asp Glu Glu Ser Phe Ile Val Phe Ser 
        195                 200                 205             


Tyr Arg Thr Cys Gly Cys Cys Ser Tyr Val Gly Arg Arg Gly Gly Gly 
    210                 215                 220                 


Pro Gln Ala Ile Ser Ile Gly Lys Asn Cys Asp Lys Phe Gly Ile Val 
225                 230                 235                 240 


Ala His Glu Leu Gly His Val Val Gly Phe Trp His Glu His Thr Arg 
                245                 250                 255     


Pro Asp Arg Asp Gln His Val Thr Ile Ile Arg Glu Asn Ile Gln Pro 
            260                 265                 270         


Gly Gln Glu Tyr Asn Phe Leu Lys Met Glu Ala Gly Glu Val Ser Ser 
        275                 280                 285             


Leu Gly Glu Thr Tyr Asp Phe Asp Ser Ile Met His Tyr Ala Arg Asn 
    290                 295                 300                 


Thr Phe Ser Arg Gly Val Phe Leu Asp Thr Ile Leu Pro Arg Gln Asp 
305                 310                 315                 320 


Asp Asn Gly Val Arg Pro Thr Ile Gly Gln Arg Val Arg Leu Ser Gln 
                325                 330                 335     


Gly Asp Ile Ala Gln Ala Arg Lys Leu Tyr Lys Cys Pro Ala Cys Gly 
            340                 345                 350         


Glu Thr Leu Gln Asp Thr Thr Gly Asn Phe Ser Ala Pro Gly Phe Pro 
        355                 360                 365             


Asn Gly Tyr Pro Ser Tyr Ser His Cys Val Trp Arg Ile Ser Val Thr 
    370                 375                 380                 


Pro Gly Glu Lys Ile Val Leu Asn Phe Thr Ser Met Asp Leu Phe Lys 
385                 390                 395                 400 


Ser Arg Leu Cys Trp Tyr Asp Tyr Val Glu Val Arg Asp Gly Tyr Trp 
                405                 410                 415     


Arg Lys Ala Pro Leu Leu Gly Arg Phe Cys Gly Asp Lys Ile Pro Glu 
            420                 425                 430         


Pro Leu Val Ser Thr Asp Ser Arg Leu Trp Val Glu Phe Arg Ser Ser 
        435                 440                 445             


Ser Asn Ile Leu Gly Lys Gly Phe Phe Ala Ala Tyr Glu Ala Thr Cys 
    450                 455                 460                 


Gly Gly Asp Met Asn Lys Asp Ala Gly Gln Ile Gln Ser Pro Asn Tyr 
465                 470                 475                 480 


Pro Asp Asp Tyr Arg Pro Ser Lys Glu Cys Val Trp Arg Ile Thr Val 
                485                 490                 495     


Ser Glu Gly Phe His Val Gly Leu Thr Phe Gln Ala Phe Glu Ile Glu 
            500                 505                 510         


Arg His Asp Ser Cys Ala Tyr Asp Tyr Leu Glu Val Arg Asp Gly Pro 
        515                 520                 525             


Thr Glu Glu Ser Ala Leu Ile Gly His Phe Cys Gly Tyr Glu Lys Pro 
    530                 535                 540                 


Glu Asp Val Lys Ser Ser Ser Asn Arg Leu Trp Met Lys Phe Val Ser 
545                 550                 555                 560 


Asp Gly Ser Ile Asn Lys Ala Gly Phe Ala Ala Asn Phe Phe Lys Glu 
                565                 570                 575     


Val Asp Glu Cys Ser Trp Pro Asp His Gly Gly Cys Glu His Arg Cys 
            580                 585                 590         


Val Asn Thr Leu Gly Ser Tyr Lys Cys Ala Cys Asp Pro Gly Tyr Glu 
        595                 600                 605             


Leu Ala Ala Asp Lys Lys Met Cys Glu Val Ala Cys Gly Gly Phe Ile 
    610                 615                 620                 


Thr Lys Leu Asn Gly Thr Ile Thr Ser Pro Gly Trp Pro Lys Glu Tyr 
625                 630                 635                 640 


Pro Thr Asn Lys Asn Cys Val Trp Gln Val Val Ala Pro Ala Gln Tyr 
                645                 650                 655     


Arg Ile Ser Leu Gln Phe Glu Val Phe Glu Leu Glu Gly Asn Asp Val 
            660                 665                 670         


Cys Lys Tyr Asp Phe Val Glu Val Arg Ser Gly Leu Ser Pro Asp Ala 
        675                 680                 685             


Lys Leu His Gly Arg Phe Cys Gly Ser Glu Thr Pro Glu Val Ile Thr 
    690                 695                 700                 


Ser Gln Ser Asn Asn Met Arg Val Glu Phe Lys Ser Asp Asn Thr Val 
705                 710                 715                 720 


Ser Lys Arg Gly Phe Arg Ala His Phe Phe Ser Asp Lys Asp Glu Cys 
                725                 730                 735     


Ala Lys Asp Asn Gly Gly Cys Gln His Glu Cys Val Asn Thr Phe Gly 
            740                 745                 750         


Ser Tyr Leu Cys Arg Cys Arg Asn Gly Tyr Trp Leu His Glu Asn Gly 
        755                 760                 765             


His Asp Cys Lys Glu Ala Gly Cys Ala His Lys Ile Ser Ser Val Glu 
    770                 775                 780                 


Gly Thr Leu Ala Ser Pro Asn Trp Pro Asp Lys Tyr Pro Ser Arg Arg 
785                 790                 795                 800 


Glu Cys Thr Trp Asn Ile Ser Ser Thr Ala Gly His Arg Val Lys Leu 
                805                 810                 815     


Thr Phe Asn Glu Phe Glu Ile Glu Gln His Gln Glu Cys Ala Tyr Asp 
            820                 825                 830         


His Leu Glu Met Tyr Asp Gly Pro Asp Ser Leu Ala Pro Ile Leu Gly 
        835                 840                 845             


Arg Phe Cys Gly Ser Lys Lys Pro Asp Pro Thr Val Ala Ser Gly Ser 
    850                 855                 860                 


Ser Met Phe Leu Arg Phe Tyr Ser Asp Ala Ser Val Gln Arg Lys Gly 
865                 870                 875                 880 


Phe Gln Ala Val His Ser Thr Glu Cys Gly Gly Arg Leu Lys Ala Glu 
                885                 890                 895     


Val Gln Thr Lys Glu Leu Tyr Ser His Ala Gln Phe Gly Asp Asn Asn 
            900                 905                 910         


Tyr Pro Ser Glu Ala Arg Cys Asp Trp Val Ile Val Ala Glu Asp Gly 
        915                 920                 925             


Tyr Gly Val Glu Leu Thr Phe Arg Thr Phe Glu Val Glu Glu Glu Ala 
    930                 935                 940                 


Asp Cys Gly Tyr Asp Tyr Met Glu Ala Tyr Asp Gly Tyr Asp Ser Ser 
945                 950                 955                 960 


Ala Pro Arg Leu Gly Arg Phe Cys Gly Ser Gly Pro Leu Glu Glu Ile 
                965                 970                 975     


Tyr Ser Ala Gly Asp Ser Leu Met Ile Arg Phe Arg Thr Asp Asp Thr 
            980                 985                 990         


Ile Asn Lys Lys Gly Phe His Ala  Arg Tyr Thr Ser Thr  Lys Phe Gln 
        995                 1000                 1005             


Asp Ala  Leu His Met Lys Lys  Leu Glu Val Leu Phe  Gln Gly Pro 
    1010                 1015                 1020             


His His  His His His His Asp  Tyr Lys Asp Asp Asp  Asp Lys 
    1025                 1030                 1035         


<210>  7
<211>  617
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  7

Met Glu Leu Arg Pro Trp Leu Leu Trp Val Val Ala Ala Thr Gly Thr 
1               5                   10                  15      


Leu Val Leu Leu Ala Ala Asp Ala Gln Gly Gln Lys Val Phe Thr Asn 
            20                  25                  30          


Thr Trp Ala Val Arg Ile Pro Gly Gly Pro Ala Val Ala Asn Ser Val 
        35                  40                  45              


Ala Arg Lys His Gly Phe Leu Asn Leu Gly Gln Ile Phe Gly Asp Tyr 
    50                  55                  60                  


Tyr His Phe Trp His Arg Gly Val Thr Lys Arg Ser Leu Ser Pro His 
65                  70                  75                  80  


Arg Pro Arg His Ser Arg Leu Gln Arg Glu Pro Gln Val Gln Trp Leu 
                85                  90                  95      


Glu Gln Gln Val Ala Lys Arg Arg Thr Lys Arg Asp Val Tyr Gln Glu 
            100                 105                 110         


Pro Thr Asp Pro Lys Phe Pro Gln Gln Trp Tyr Leu Ser Gly Val Thr 
        115                 120                 125             


Gln Arg Asp Leu Asn Val Lys Ala Ala Trp Ala Gln Gly Tyr Thr Gly 
    130                 135                 140                 


His Gly Ile Val Val Ser Ile Leu Asp Asp Gly Ile Glu Lys Asn His 
145                 150                 155                 160 


Pro Asp Leu Ala Gly Asn Tyr Asp Pro Gly Ala Ser Phe Asp Val Asn 
                165                 170                 175     


Asp Gln Asp Pro Asp Pro Gln Pro Arg Tyr Thr Gln Met Asn Asp Asn 
            180                 185                 190         


Arg His Gly Thr Arg Cys Ala Gly Glu Val Ala Ala Val Ala Asn Asn 
        195                 200                 205             


Gly Val Cys Gly Val Gly Val Ala Tyr Asn Ala Arg Ile Gly Gly Val 
    210                 215                 220                 


Arg Met Leu Asp Gly Glu Val Thr Asp Ala Val Glu Ala Arg Ser Leu 
225                 230                 235                 240 


Gly Leu Asn Pro Asn His Ile His Ile Tyr Ser Ala Ser Trp Gly Pro 
                245                 250                 255     


Glu Asp Asp Gly Lys Thr Val Asp Gly Pro Ala Arg Leu Ala Glu Glu 
            260                 265                 270         


Ala Phe Phe Arg Gly Val Ser Gln Gly Arg Gly Gly Leu Gly Ser Ile 
        275                 280                 285             


Phe Val Trp Ala Ser Gly Asn Gly Gly Arg Glu His Asp Ser Cys Asn 
    290                 295                 300                 


Cys Asp Gly Tyr Thr Asn Ser Ile Tyr Thr Leu Ser Ile Ser Ser Ala 
305                 310                 315                 320 


Thr Gln Phe Gly Asn Val Pro Trp Tyr Ser Glu Ala Cys Ser Ser Thr 
                325                 330                 335     


Leu Ala Thr Thr Tyr Ser Ser Gly Asn Gln Asn Glu Lys Gln Ile Val 
            340                 345                 350         


Thr Thr Asp Leu Arg Gln Lys Cys Thr Glu Ser His Thr Gly Thr Ser 
        355                 360                 365             


Ala Ser Ala Pro Leu Ala Ala Gly Ile Ile Ala Leu Thr Leu Glu Ala 
    370                 375                 380                 


Asn Lys Asn Leu Thr Trp Arg Asp Met Gln His Leu Val Val Gln Thr 
385                 390                 395                 400 


Ser Lys Pro Ala His Leu Asn Ala Asn Asp Trp Ala Thr Asn Gly Val 
                405                 410                 415     


Gly Arg Lys Val Ser His Ser Tyr Gly Tyr Gly Leu Leu Asp Ala Gly 
            420                 425                 430         


Ala Met Val Ala Leu Ala Gln Asn Trp Thr Thr Val Ala Pro Gln Arg 
        435                 440                 445             


Lys Cys Ile Ile Asp Ile Leu Thr Glu Pro Lys Asp Ile Gly Lys Arg 
    450                 455                 460                 


Leu Glu Val Arg Lys Thr Val Thr Ala Cys Leu Gly Glu Pro Asn His 
465                 470                 475                 480 


Ile Thr Arg Leu Glu His Ala Gln Ala Arg Leu Thr Leu Ser Tyr Asn 
                485                 490                 495     


Arg Arg Gly Asp Leu Ala Ile His Leu Val Ser Pro Met Gly Thr Arg 
            500                 505                 510         


Ser Thr Leu Leu Ala Ala Arg Pro His Asp Tyr Ser Ala Asp Gly Phe 
        515                 520                 525             


Asn Asp Trp Ala Phe Met Thr Thr His Ser Trp Asp Glu Asp Pro Ser 
    530                 535                 540                 


Gly Glu Trp Val Leu Glu Ile Glu Asn Thr Ser Glu Ala Asn Asn Tyr 
545                 550                 555                 560 


Gly Thr Leu Thr Lys Phe Thr Leu Val Leu Tyr Gly Thr Ala Pro Glu 
                565                 570                 575     


Gly Leu Pro Val Pro Pro Glu Ser Ser Gly Cys Lys Thr Leu Thr Ser 
            580                 585                 590         


Ser Gln Ala Leu Glu Val Leu Phe Gln Gly Pro His His His His His 
        595                 600                 605             


His Asp Tyr Lys Asp Asp Asp Asp Lys 
    610                 615         


<210>  8
<211>  935
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  8

Met Gly Trp Gly Ser Arg Cys Cys Cys Pro Gly Arg Leu Asp Leu Leu 
1               5                   10                  15      


Cys Val Leu Ala Leu Leu Gly Gly Cys Leu Leu Pro Val Cys Arg Thr 
            20                  25                  30          


Arg Val Tyr Thr Asn His Trp Ala Val Lys Ile Ala Gly Gly Phe Pro 
        35                  40                  45              


Glu Ala Asn Arg Ile Ala Ser Lys Tyr Gly Phe Ile Asn Ile Gly Gln 
    50                  55                  60                  


Ile Gly Ala Leu Lys Asp Tyr Tyr His Phe Tyr His Ser Arg Thr Ile 
65                  70                  75                  80  


Lys Arg Ser Val Ile Ser Ser Arg Gly Thr His Ser Phe Ile Ser Met 
                85                  90                  95      


Glu Pro Lys Val Glu Trp Ile Gln Gln Gln Val Val Lys Lys Arg Thr 
            100                 105                 110         


Lys Arg Asp Tyr Asp Phe Ser Arg Ala Gln Ser Thr Tyr Phe Asn Asp 
        115                 120                 125             


Pro Lys Trp Pro Ser Met Trp Tyr Met His Cys Ser Asp Asn Thr His 
    130                 135                 140                 


Pro Cys Gln Ser Asp Met Asn Ile Glu Gly Ala Trp Lys Arg Gly Tyr 
145                 150                 155                 160 


Thr Gly Lys Asn Ile Val Val Thr Ile Leu Asp Asp Gly Ile Glu Arg 
                165                 170                 175     


Thr His Pro Asp Leu Met Gln Asn Tyr Asp Ala Leu Ala Ser Cys Asp 
            180                 185                 190         


Val Asn Gly Asn Asp Leu Asp Pro Met Pro Arg Tyr Asp Ala Ser Asn 
        195                 200                 205             


Glu Asn Lys His Gly Thr Arg Cys Ala Gly Glu Val Ala Ala Ala Ala 
    210                 215                 220                 


Asn Asn Ser His Cys Thr Val Gly Ile Ala Phe Asn Ala Lys Ile Gly 
225                 230                 235                 240 


Gly Val Arg Met Leu Asp Gly Asp Val Thr Asp Met Val Glu Ala Lys 
                245                 250                 255     


Ser Val Ser Phe Asn Pro Gln His Val His Ile Tyr Ser Ala Ser Trp 
            260                 265                 270         


Gly Pro Asp Asp Asp Gly Lys Thr Val Asp Gly Pro Ala Pro Leu Thr 
        275                 280                 285             


Arg Gln Ala Phe Glu Asn Gly Val Arg Met Gly Arg Arg Gly Leu Gly 
    290                 295                 300                 


Ser Val Phe Val Trp Ala Ser Gly Asn Gly Gly Arg Ser Lys Asp His 
305                 310                 315                 320 


Cys Ser Cys Asp Gly Tyr Thr Asn Ser Ile Tyr Thr Ile Ser Ile Ser 
                325                 330                 335     


Ser Thr Ala Glu Ser Gly Lys Lys Pro Trp Tyr Leu Glu Glu Cys Ser 
            340                 345                 350         


Ser Thr Leu Ala Thr Thr Tyr Ser Ser Gly Glu Ser Tyr Asp Lys Lys 
        355                 360                 365             


Ile Ile Thr Thr Asp Leu Arg Gln Arg Cys Thr Asp Asn His Thr Gly 
    370                 375                 380                 


Thr Ser Ala Ser Ala Pro Met Ala Ala Gly Ile Ile Ala Leu Ala Leu 
385                 390                 395                 400 


Glu Ala Asn Pro Phe Leu Thr Trp Arg Asp Val Gln His Val Ile Val 
                405                 410                 415     


Arg Thr Ser Arg Ala Gly His Leu Asn Ala Asn Asp Trp Lys Thr Asn 
            420                 425                 430         


Ala Ala Gly Phe Lys Val Ser His Leu Tyr Gly Phe Gly Leu Met Asp 
        435                 440                 445             


Ala Glu Ala Met Val Met Glu Ala Glu Lys Trp Thr Thr Val Pro Arg 
    450                 455                 460                 


Gln His Val Cys Val Glu Ser Thr Asp Arg Gln Ile Lys Thr Ile Arg 
465                 470                 475                 480 


Pro Asn Ser Ala Val Arg Ser Ile Tyr Lys Ala Ser Gly Cys Ser Asp 
                485                 490                 495     


Asn Pro Asn Arg His Val Asn Tyr Leu Glu His Val Val Val Arg Ile 
            500                 505                 510         


Thr Ile Thr His Pro Arg Arg Gly Asp Leu Ala Ile Tyr Leu Thr Ser 
        515                 520                 525             


Pro Ser Gly Thr Arg Ser Gln Leu Leu Ala Asn Arg Leu Phe Asp His 
    530                 535                 540                 


Ser Met Glu Gly Phe Lys Asn Trp Glu Phe Met Thr Ile His Cys Trp 
545                 550                 555                 560 


Gly Glu Arg Ala Ala Gly Asp Trp Val Leu Glu Val Tyr Asp Thr Pro 
                565                 570                 575     


Ser Gln Leu Arg Asn Phe Lys Thr Pro Gly Lys Leu Lys Glu Trp Ser 
            580                 585                 590         


Leu Val Leu Tyr Gly Thr Ser Val Gln Pro Tyr Ser Pro Thr Asn Glu 
        595                 600                 605             


Phe Pro Lys Val Glu Arg Phe Arg Tyr Ser Arg Val Glu Asp Pro Thr 
    610                 615                 620                 


Asp Asp Tyr Gly Thr Glu Asp Tyr Ala Gly Pro Cys Asp Pro Glu Cys 
625                 630                 635                 640 


Ser Glu Val Gly Cys Asp Gly Pro Gly Pro Asp His Cys Asn Asp Cys 
                645                 650                 655     


Leu His Tyr Tyr Tyr Lys Leu Lys Asn Asn Thr Arg Ile Cys Val Ser 
            660                 665                 670         


Ser Cys Pro Pro Gly His Tyr His Ala Asp Lys Lys Arg Cys Arg Lys 
        675                 680                 685             


Cys Ala Pro Asn Cys Glu Ser Cys Phe Gly Ser His Gly Asp Gln Cys 
    690                 695                 700                 


Met Ser Cys Lys Tyr Gly Tyr Phe Leu Asn Glu Glu Thr Asn Ser Cys 
705                 710                 715                 720 


Val Thr His Cys Pro Asp Gly Ser Tyr Gln Asp Thr Lys Lys Asn Leu 
                725                 730                 735     


Cys Arg Lys Cys Ser Glu Asn Cys Lys Thr Cys Thr Glu Phe His Asn 
            740                 745                 750         


Cys Thr Glu Cys Arg Asp Gly Leu Ser Leu Gln Gly Ser Arg Cys Ser 
        755                 760                 765             


Val Ser Cys Glu Asp Gly Arg Tyr Phe Asn Gly Gln Asp Cys Gln Pro 
    770                 775                 780                 


Cys His Arg Phe Cys Ala Thr Cys Ala Gly Ala Gly Ala Asp Gly Cys 
785                 790                 795                 800 


Ile Asn Cys Thr Glu Gly Tyr Phe Met Glu Asp Gly Arg Cys Val Gln 
                805                 810                 815     


Ser Cys Ser Ile Ser Tyr Tyr Phe Asp His Ser Ser Glu Asn Gly Tyr 
            820                 825                 830         


Lys Ser Cys Lys Lys Cys Asp Ile Ser Cys Leu Thr Cys Asn Gly Pro 
        835                 840                 845             


Gly Phe Lys Asn Cys Thr Ser Cys Pro Ser Gly Tyr Leu Leu Asp Leu 
    850                 855                 860                 


Gly Met Cys Gln Met Gly Ala Ile Cys Lys Asp Ala Thr Glu Glu Ser 
865                 870                 875                 880 


Trp Ala Glu Gly Gly Phe Cys Met Leu Val Lys Lys Asn Asn Leu Cys 
                885                 890                 895     


Gln Arg Lys Val Leu Gln Gln Leu Cys Cys Lys Thr Cys Thr Phe Gln 
            900                 905                 910         


Gly Leu Glu Val Leu Phe Gln Gly Pro His His His His His His Asp 
        915                 920                 925             


Tyr Lys Asp Asp Asp Asp Lys 
    930                 935 


<210>  9
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  9

Asp Tyr Lys Asp Asp Asp Asp Lys 
1               5               


<210>  10
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  10

His His His His His His 
1               5       


<210>  11
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  11

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Phe Ser Gly Val Leu Gly 
            20          


