                               SEQUENCE LISTING

<110> BRANDEIS UNIVERSITY
 
<120> MODIFIED CAS9 COMPOSITIONS AND METHODS OF USE

<130> 167703.010301PCT

<140> PCT/US2016/058719
<141> 2016-10-25

<150> 62/249,113
<151> 2015-10-30

<160> 4     

<170> PatentIn version 3.5


<210> 1
<211> 1368
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1

Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Ala Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg Lys Arg  Tyr Thr Ser 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


<210> 2
<211> 9524
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 2

gacgaaaggg cctcgtgata cgcctatttt tataggttaa tgtcatgata ataatggttt       60

cttagacgga tcgcttgcct gtaacttaca cgcgcctcgt atcttttaat gatggaataa      120

tttgggaatt tactctgtgt ttatttattt ttatgttttg tatttggatt ttagaaagta      180

aataaagaag gtagaagagt tacggaatga agaaaaaaaa ataaacaaag gtttaaaaaa      240

tttcaacaaa aagcgtactt tacatatata tttattagac aagaaaagca gattaaatag      300

atatacattc gattaacgat aagtaaaatg taaaatcaca ggattttcgt gtgtggtctt      360

ctacacagac aagatgaaac aattcggcat taatacctga gagcaggaag agcaagataa      420

aaggtagtat ttgttggcga tccccctaga gtcttttaca tcttcggaaa acaaaaacta      480

ttttttcttt aatttctttt tttactttct atttttaatt tatatattta tattaaaaaa      540

tttaaattat aattattttt atagcacgtg atgaaaagga cccaggtggc acttttcggg      600

gaaatgtgcg cggaacccct atttgtttat ttttctaaat acattcaaat atgtatccgc      660

tcatgagaca ataaccctga taaatgcttc aataatattg aaaaaggaag agtatgagta      720

ttcaacattt ccgtgtcgcc cttattccct tttttgcggc attttgcctt cctgtttttg      780

ctcacccaga aacgctggtg aaagtaaaag atgctgaaga tcagttgggt gcacgagtgg      840

gttacatcga actggatctc aacagcggta agatccttga gagttttcgc cccgaagaac      900

gttttccaat gatgagcact tttaaagttc tgctatgtgg cgcggtatta tcccgtattg      960

acgccgggca agagcaactc ggtcgccgca tacactattc tcagaatgac ttggttgagt     1020

actcaccagt cacagaaaag catcttacgg atggcatgac agtaagagaa ttatgcagtg     1080

ctgccataac catgagtgat aacactgcgg ccaacttact tctgacaacg atcggaggac     1140

cgaaggagct aaccgctttt ttgcacaaca tgggggatca tgtaactcgc cttgatcgtt     1200

gggaaccgga gctgaatgaa gccataccaa acgacgagcg tgacaccacg atgcctgtag     1260

caatggcaac aacgttgcgc aaactattaa ctggcgaact acttactcta gcttcccggc     1320

aacaattaat agactggatg gaggcggata aagttgcagg accacttctg cgctcggccc     1380

ttccggctgg ctggtttatt gctgataaat ctggagccgg tgagcgtggg tctcgcggta     1440

tcattgcagc actggggcca gatggtaagc cctcccgtat cgtagttatc tacacgacgg     1500

ggagtcaggc aactatggat gaacgaaata gacagatcgc tgagataggt gcctcactga     1560

ttaagcattg gtaactgtca gaccaagttt actcatatat actttagatt gatttaaaac     1620

ttcattttta atttaaaagg atctaggtga agatcctttt tgataatctc atgaccaaaa     1680

tcccttaacg tgagttttcg ttccactgag cgtcagaccc cgtagaaaag atcaaaggat     1740

cttcttgaga tccttttttt ctgcgcgtaa tctgctgctt gcaaacaaaa aaaccaccgc     1800

taccagcggt ggtttgtttg ccggatcaag agctaccaac tctttttccg aaggtaactg     1860

gcttcagcag agcgcagata ccaaatactg tccttctagt gtagccgtag ttaggccacc     1920

acttcaagaa ctctgtagca ccgcctacat acctcgctct gctaatcctg ttaccagtgg     1980

ctgctgccag tggcgataag tcgtgtctta ccgggttgga ctcaagacga tagttaccgg     2040

ataaggcgca gcggtcgggc tgaacggggg gttcgtgcac acagcccagc ttggagcgaa     2100

cgacctacac cgaactgaga tacctacagc gtgagctatg agaaagcgcc acgcttcccg     2160

aagggagaaa ggcggacagg tatccggtaa gcggcagggt cggaacagga gagcgcacga     2220

gggagcttcc agggggaaac gcctggtatc tttatagtcc tgtcgggttt cgccacctct     2280

gacttgagcg tcgatttttg tgatgctcgt caggggggcg gagcctatgg aaaaacgcca     2340

gcaacgcggc ctttttacgg ttcctggcct tttgctggcc ttttgctcac atgttctttc     2400

ctgcgttatc ccctgattct gtggataacc gtattaccgc ctttgagtga gctgataccg     2460

ctcgccgcag ccgaacgacc gagcgcagcg agtcagtgag cgaggaagcg gaagagcgcc     2520

caatacgcaa accgcctctc cccgcgcgtt ggccgattca ttaatgcagc tggcacgaca     2580

ggtttcccga ctggaaagcg ggcagtgagc gcaacgcaat taatgtgagt tacctcactc     2640

attaggcacc ccaggcttta cactttatgc ttccggctcc tatgttgtgt ggaattgtga     2700

gcggataaca atttcacaca ggaaacagct atgaccatga ttacgccaag cgcgcaatta     2760

accctcacta aagggaacaa aagctggagc tcatagcttc aaaatgtttc tactcctttt     2820

ttactcttcc agattttctc ggactccgcg catcgccgta ccacttcaaa acacccaagc     2880

acagcatact aaatttcccc tctttcttcc tctagggtgt cgttaattac ccgtactaaa     2940

ggtttggaaa agaaaaaaga gaccgcctcg tttctttttc ttcgtcgaaa aaggcaataa     3000

aaatttttat cacgtttctt tttcttgaaa attttttttt tgattttttt ctctttcgat     3060

gacctcccat tgatatttaa gttaataaac ggtcttcaat ttctcaagtt tcagtttcat     3120

ttttcttgtt ctattacaac tttttttact tcttgctcat tagaaagaaa gcatagcaat     3180

ctaatctaag ttttctagaa ctagtggatc ccccgggaaa aatggacaag aagtactcca     3240

ttgggctcga tatcggcaca aacagcgtcg gttgggccgt cattacggac gagtacaagg     3300

tgccgagcaa aaaattcaaa gttctgggca ataccgatcg ccacagcata aagaagaacc     3360

tcattggcgc cctcctgttc gactccgggg agacggccga agccacgcgg ctcaaaagaa     3420

cagcacggcg cagatatacc cgcagaaaga atcggatctg ctacctgcag gagatcttta     3480

gtaatgagat ggctaaggtg gatgactctt tcttccatag gctggaggag tcctttttgg     3540

tggaggagga taaaaagcac gagcgccacc caatctttgg caatatcgtg gacgaggtgg     3600

cgtaccatga aaagtaccca accatatatc atctgaggaa gaagcttgta gacagtactg     3660

ataaggctga cttgcggttg atctatctcg cgctggcgca tatgatcaaa tttcggggac     3720

acttcctcat cgagggggac ctgaacccag acaacagcga tgtcgacaaa ctctttatcc     3780

aactggttca gacttacaat cagcttttcg aagagaaccc gatcaacgca tccggagttg     3840

acgccaaagc aatcctgagc gctaggctgt ccaaatcccg gcggctcgaa aacctcatcg     3900

cacagctccc tggggagaag aagaacggcc tgtttggtaa tcttatcgcc ctgtcactcg     3960

ggctgacccc caactttaaa tctaacttcg acctggccga agatgccaag cttcaactga     4020

gcaaagacac ctacgatgat gatctcgaca atctgctggc ccagatcggc gaccagtacg     4080

cagacctttt tttggcggca aagaacctgt cagacgccat tctgctgagt gatattctgc     4140

gagtgaacac ggagatcacc aaagctccgc tgagcgctag tatgatcaag cgctatgatg     4200

agcaccacca agacttgact ttgctgaagg cccttgtcag acagcaactg cctgagaagt     4260

acaaggaaat tttcttcgat cagtctaaaa atggctacgc cggatacatt gacggcggag     4320

caagccagga ggaattttac aaatttatta agcccatctt ggaaaaaatg gacggcaccg     4380

aggagctgct ggtaaagctt aacagagaag atctgttgcg caaacagcgc actttcgaca     4440

atggaagcat cccccaccag attcacctgg gcgaactgca cgctatcctc aggcggcaag     4500

aggatttcta cccctttttg aaagataaca gggaaaagat tgagaaaatc ctcacatttc     4560

ggatacccta ctatgtaggc cccctcgccc ggggaaattc cagattcgcg tggatgactc     4620

gcaaatcaga agagaccatc actccctgga acttcgagga agtcgtggat aagggggcct     4680

ctgcccagtc cttcatcgaa aggatgacta actttgataa aaatctgcct aacgaaaagg     4740

tgcttcctaa acactctctg ctgtacgagt acttcacagt ttataacgag ctcaccaagg     4800

tcaaatacgt cacagaaggg atgagaaagc cagcattcct gtctggagag cagaagaaag     4860

ctatcgtgga cctcctcttc aagacgaacc ggaaagttac cgtgaaacag ctcaaagaag     4920

actatttcaa aaagattgaa tgtttcgact ctgttgaaat cagcggagtg gaggatcgct     4980

tcaacgcatc cctgggaacg tatcacgatc tcctgaaaat cattaaagac aaggacttcc     5040

tggacaatga ggagaacgag gacattcttg aggacattgt cctcaccctt acgttgtttg     5100

aagataggga gatgattgaa gaacgcttga aaacttacgc tcatctcttc gacgacaaag     5160

tcatgaaaca gctcaagagg cgccgatata caggatgggg gcggctgtca agaaaactga     5220

tcaatgggat ccgagacaag cagagtggaa agacaatcct ggattttctt aagtccgatg     5280

gatttgccaa ccggaacttc atgcagttga tccatgatga ctctctcacc tttaaggagg     5340

acatccagaa agcacaagtt tctggccagg gggacagtct tcacgagcac atcgctaatc     5400

ttgcaggtag cccagctatc aaaaagggaa tactgcagac cgttaaggtc gtggatgaac     5460

tcgtcaaagt aatgggaagg cataagcccg agaatatcgt tatcgagatg gcccgagaga     5520

accaaactac ccagaaggga cagaagaaca gtagggaaag gatgaagagg attgaagagg     5580

gtataaaaga actggggtcc caaatcctta aggaacaccc agttgaaaac acccagcttc     5640

agaatgagaa gctctacctg tactacctgc agaacggcag ggacatgtac gtggatcagg     5700

aactggacat caatcggctc tccgactacg acgtggatca tatcgtgccc cagtcttttc     5760

tcaaagatga ttctattgat aataaagtgt tgacaagatc cgataaaaat agagggaaga     5820

gtgataacgt cccctcagaa gaagttgtca agaaaatgaa aaattattgg cggcagctgc     5880

tgaacgccaa actgatcaca caacggaagt tcgataatct gactaaggct gaacgaggtg     5940

gcctgtctga gttggataaa gccggcttca tcaaaaggca gcttgttgag acacgccaga     6000

tcaccaagca cgtggcccaa attctcgatt cacgcatgaa caccaagtac gatgaaaatg     6060

acaaactgat tcgagaggtg aaagttatta ctctgaagtc taagctggtc tcagatttca     6120

gaaaggactt tcagttttat aaggtgagag agatcaacaa ttaccaccat gcgcatgatg     6180

cctacctgaa tgcagtggta ggcactgcac ttatcaaaaa atatcccaag cttgaatctg     6240

aatttgttta cggagactat aaagtgtacg atgttaggaa aatgatcgca aagtctgagc     6300

aggaaatagg caaggccacc gctaagtact tcttttacag caatattatg aattttttca     6360

agaccgagat tacactggcc aatggagaga ttcggaagcg accacttatc gaaacaaacg     6420

gagaaacagg agaaatcgtg tgggacaagg gtagggattt cgcgacagtc cggaaggtcc     6480

tgtccatgcc gcaggtgaac atcgttaaaa agaccgaagt acagaccgga ggcttctcca     6540

aggaaagtat cctcccgaaa aggaacagcg acaagctgat cgcacgcaaa aaagattggg     6600

accccaagaa atacggcgga ttcgattctc ctacagtcgc ttacagtgta ctggttgtgg     6660

ccaaagtgga gaaagggaag tctaaaaaac tcaaaagcgt caaggaactg ctgggcatca     6720

caatcatgga gcgatcaagc ttcgaaaaaa accccatcga ctttctcgag gcgaaaggat     6780

ataaagaggt caaaaaagac ctcatcatta agcttcccaa gtactctctc tttgagcttg     6840

aaaacggccg gaaacgaatg ctcgctagtg cgggcgagct gcagaaaggt aacgagctgg     6900

cactgccctc taaatacgtt aatttcttgt atctggccag ccactatgaa aagctcaaag     6960

ggtctcccga agataatgag cagaagcagc tgttcgtgga acaacacaaa cactaccttg     7020

atgagatcat cgagcaaata agcgaattct ccaaaagagt gatcctcgcc gacgctaacc     7080

tcgataaggt gctttctgct tacaataagc acagggataa gcccatcagg gagcaggcag     7140

aaaacattat ccacttgttt actctgacca acttgggcgc gcctgcagcc ttcaagtact     7200

tcgacaccac catagacaga aagcggtaca cctctacaaa ggaggtcctg gacgccacac     7260

tgattcatca gtcaattacg gggctctatg aaacaagaat cgacctctct cagctcggtg     7320

gagacagcag ggctgacccc aagaagaaga ggaaggtgtg atctcttctc gagtcatgta     7380

attagttatg tcacgcttac attcacgccc tccccccaca tccgctctaa ccgaaaagga     7440

aggagttaga caacctgaag tctaggtccc tatttatttt tttatagtta tgttagtatt     7500

aagaacgtta tttatatttc aaatttttct tttttttctg tacagacgcg tgtacgcatg     7560

taacattata ctgaaaacct tgcttgagaa ggttttggga cgctcgaagg ctttaatttg     7620

cggccggtac ccaattcgcc ctatagtgag tcgtattacg cgcgctcact ggccgtcgtt     7680

ttacaacgtc gtgactggga aaaccctggc gttacccaac ttaatcgcct tgcagcacat     7740

ccccctttcg ccagctggcg taatagcgaa gaggcccgca ccgatcgccc ttcccaacag     7800

ttgcgcagcc tgaatggcga atggcgcgac gcgccctgta gcggcgcatt aagcgcggcg     7860

ggtgtggtgg ttacgcgcag cgtgaccgct acacttgcca gcgccctagc gcccgctcct     7920

ttcgctttct tcccttcctt tctcgccacg ttcgccggct ttccccgtca agctctaaat     7980

cgggggctcc ctttagggtt ccgatttagt gctttacggc acctcgaccc caaaaaactt     8040

gattagggtg atggttcacg tagtgggcca tcgccctgat agacggtttt tcgccctttg     8100

acgttggagt ccacgttctt taatagtgga ctcttgttcc aaactggaac aacactcaac     8160

cctatctcgg tctattcttt tgatttataa gggattttgc cgatttcggc ctattggtta     8220

aaaaatgagc tgatttaaca aaaatttaac gcgaatttta acaaaatatt aacgtttaca     8280

atttcctgat gcggtatttt ctccttacgc atctgtgcgg tatttcacac cgcataggca     8340

agtgcacaaa caatacttaa ataaatacta ctcagtaata acctatttct tagcattttt     8400

gacgaaattt gctattttgt tagagtcttt tacaccattt gtctccacac ctccgcttac     8460

atcaacacca ataacgccat ttaatctaag cgcatcacca acattttctg gcgtcagtcc     8520

accagctaac ataaaatgta agctttcggg gctctcttgc cttccaaccc agtcagaaat     8580

cgagttccaa tccaaaagtt cacctgtccc acctgcttct gaatcaaaca agggaataaa     8640

cgaatgaggt ttctgtgaag ctgcactgag tagtatgttg cagtcttttg gaaatacgag     8700

tcttttaata actggcaaac cgaggaactc ttggtattct tgccacgact catctccatg     8760

cagttggacg atatcaatgc cgtaatcatt gaccagagcc aaaacatcct ccttaggttg     8820

attacgaaac acgccaacca agtatttcgg agtgcctgaa ctatttttat atgcttttac     8880

aagacttgaa attttccttg caataaccgg gtcaattgtt ctctttctat tgggcacaca     8940

tataataccc agcaagtcag catcggaatc tagagcacat tctgcggcct ctgtgctctg     9000

caagccgcaa actttcacca atggaccaga actacctgtg aaattaataa cagacatact     9060

ccaagctgcc tttgtgtgct taatcacgta tactcacgtg ctcaatagtc accaatgccc     9120

tccctcttgg ccctctcctt ttcttttttc gaccgaatta attcttaatc ggcaaaaaaa     9180

gaaaagctcc ggatcaagat tgtacgtaag gtgacaagct atttttcaat aaagaatatc     9240

ttccactact gccatctggc gtcataactg caaagtacac atatattacg atgctgtcta     9300

ttaaatgctt cctatattat atatatagta atgtcgttta tggtgcactc tcagtacaat     9360

ctgctctgat gccgcatagt taagccagcc ccgacacccg ccaacacccg ctgacgcgcc     9420

ctgacgggct tgtctgctcc cggcatccgc ttacagacaa gctgtgaccg tctccgggag     9480

ctgcatgtgt cagaggtttt caccgtcatc accgaaacgc gcga                      9524


<210> 3
<211> 4722
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 3

atggacaaga agtactccat tgggctcgat atcggcacaa acagcgtcgg ctgggccgtc       60

attacggacg agtacaaggt gccgagcaaa aaattcaaag ttctgggcaa taccgatcgc      120

cacagcataa agaagaacct cattggcgcc ctcctgttcg actccgggga gacggccgaa      180

gccacgcggc tcaaaagaac agcacggcgc agatataccc gcagaaagaa tcggatctgc      240

tacctgcagg agatctttag taatgagatg gctaaggtgg atgactcttt cttccatagg      300

ctggaggagt cctttttggt ggaggaggat aaaaagcacg agcgccaccc aatctttggc      360

aatatcgtgg acgaggtggc gtaccatgaa aagtacccaa ccatatatca tctgaggaag      420

aagcttgtag acagtactga taaggctgac ttgcggttga tctatctcgc gctggcgcat      480

atgatcaaat ttcggggaca cttcctcatc gagggggacc tgaacccaga caacagcgat      540

gtcgacaaac tctttatcca actggttcag acttacaatc agcttttcga agagaacccg      600

atcaacgcat ccggagttga cgccaaagca atcctgagcg ctaggctgtc caaatcccgg      660

cggctcgaaa acctcatcgc acagctccct ggggagaaga agaacggcct gtttggtaat      720

cttatcgccc tgtcactcgg gctgaccccc aactttaaat ctaacttcga cctggccgaa      780

gatgccaagc ttcaactgag caaagacacc tacgatgatg atctcgacaa tctgctggcc      840

cagatcggcg accagtacgc agaccttttt ttggcggcaa agaacctgtc agacgccatt      900

ctgctgagtg atattctgcg agtgaacacg gagatcacca aagctccgct gagcgctagt      960

atgatcaagc gctatgatga gcaccaccaa gacttgactt tgctgaaggc ccttgtcaga     1020

cagcaactgc ctgagaagta caaggaaatt ttcttcgatc agtctaaaaa tggctacgcc     1080

ggatacattg acggcggagc aagccaggag gaattttaca aatttattaa gcccatcttg     1140

gaaaaaatgg acggcaccga ggagctgctg gtaaagctta acagagaaga tctgttgcgc     1200

aaacagcgca ctttcgacaa tggaagcatc ccccaccaga ttcacctggg cgaactgcac     1260

gctatcctca ggcggcaaga ggatttctac ccctttttga aagataacag ggaaaagatt     1320

gagaaaatcc tcacatttcg gataccctac tatgtaggcc ccctcgcccg gggaaattcc     1380

agattcgcgt ggatgactcg caaatcagaa gagaccatca ctccctggaa cttcgaggaa     1440

gtcgtggata agggggcctc tgcccagtcc ttcatcgaaa ggatgactaa ctttgataaa     1500

aatctgccta acgaaaaggt gcttcctaaa cactctctgc tgtacgagta cttcacagtt     1560

tataacgagc tcaccaaggt caaatacgtc acagaaggga tgagaaagcc agcattcctg     1620

tctggagagc agaagaaagc tatcgtggac ctcctcttca agacgaaccg gaaagttacc     1680

gtgaaacagc tcaaagaaga ctatttcaaa aagattgaat gtttcgactc tgttgaaatc     1740

agcggagtgg aggatcgctt caacgcatcc ctgggaacgt atcacgatct cctgaaaatc     1800

attaaagaca aggacttcct ggacaatgag gagaacgagg acattcttga ggacattgtc     1860

ctcaccctta cgttgtttga agatagggag atgattgaag aacgcttgaa aacttacgct     1920

catctcttcg acgacaaagt catgaaacag ctcaagaggc gccgatatac aggatggggg     1980

cggctgtcaa gaaaactgat caatgggatc cgagacaagc agagtggaaa gacaatcctg     2040

gattttctta agtccgatgg atttgccaac cggaacttca tgcagttgat ccatgatgac     2100

tctctcacct ttaaggagga catccagaaa gcacaagttt ctggccaggg ggacagtctt     2160

cacgagcaca tcgctaatct tgcaggtagc ccagctatca aaaagggaat actgcagacc     2220

gttaaggtcg tggatgaact cgtcaaagta atgggaaggc ataagcccga gaatatcgtt     2280

atcgagatgg cccgagagaa ccaaactacc cagaagggac agaagaacag tagggaaagg     2340

atgaagagga ttgaagaggg tataaaagaa ctggggtccc aaatccttaa ggaacaccca     2400

gttgaaaaca cccagcttca gaatgagaag ctctacctgt actacctgca gaacggcagg     2460

gacatgtacg tggatcagga actggacatc aatcggctct ccgactacga cgtggatcat     2520

atcgtgcccc agtcttttct caaagatgat tctattgata ataaagtgtt gacaagatcc     2580

gataaaaata gagggaagag tgataacgtc ccctcagaag aagttgtcaa gaaaatgaaa     2640

aattattggc ggcagctgct gaacgccaaa ctgatcacac aacggaagtt cgataatctg     2700

actaaggctg aacgaggtgg cctgtctgag ttggataaag ccggcttcat caaaaggcag     2760

cttgttgaga cacgccagat caccaagcac gtggcccaaa ttctcgattc acgcatgaac     2820

accaagtacg atgaaaatga caaactgatt cgagaggtga aagttattac tctgaagtct     2880

aagctggtct cagatttcag aaaggacttt cagttttata aggtgagaga gatcaacaat     2940

taccaccatg cgcatgatgc ctacctgaat gcagtggtag gcactgcact tatcaaaaaa     3000

tatcccaagc ttgaatctga atttgtttac ggagactata aagtgtacga tgttaggaaa     3060

atgatcgcaa agtctgagca ggaaataggc aaggccaccg ctaagtactt cttttacagc     3120

aatattatga attttttcaa gaccgagatt acactggcca atggagagat tcggaagcga     3180

ccacttatcg aaacaaacgg agaaacagga gaaatcgtgt gggacaaggg tagggatttc     3240

gcgacagtcc ggaaggtcct gtccatgccg caggtgaaca tcgttaaaaa gaccgaagta     3300

cagaccggag gcttctccaa ggaaagtatc ctcccgaaaa ggaacagcga caagctgatc     3360

gcacgcaaaa aagattggga ccccaagaaa tacggcggat tcgattctcc tacagtcgct     3420

tacagtgtac tggttgtggc caaagtggag aaagggaagt ctaaaaaact caaaagcgtc     3480

aaggaactgc tgggcatcac aatcatggag cgatcaagct tcgaaaaaaa ccccatcgac     3540

tttctcgagg cgaaaggata taaagaggtc aaaaaagacc tcatcattaa gcttcccaag     3600

tactctctct ttgagcttga aaacggccgg aaacgaatgc tcgctagtgc gggcgagctg     3660

cagaaaggta acgagctggc actgccctct aaatacgtta atttcttgta tctggccagc     3720

cactatgaaa agctcaaagg gtctcccgaa gataatgagc agaagcagct gttcgtggaa     3780

caacacaaac actaccttga tgagatcatc gagcaaataa gcgaattctc caaaagagtg     3840

atcctcgccg acgctaacct cgataaggtg ctttctgctt acaataagca cagggataag     3900

cccatcaggg agcaggcaga aaacattatc cacttgttta ctctgaccaa cttgggcgcg     3960

cctgcagcct tcaagtactt cgacaccacc atagacagaa agcggtacac ctctacaaag     4020

gaggtcctgg acgccacact gattcatcag tcaattacgg ggctctatga aacaagaatc     4080

gacctctctc agctcggtgg agacagcagg gctgacccca agaagaagag gaaggtggct     4140

agcatggaca aagactgcga aatgaagcgc accaccctgg atagccctct gggcaagctg     4200

gaactgtctg ggtgcgaaca gggcctgcac cgtatcatct tcctgggcaa aggaacatct     4260

gccgccgacg ccgtggaagt gcctgcccca gccgccgtgc tgggcggacc agagccactg     4320

atgcaggcca ccgcctggct caacgcctac tttcaccagc ctgaggccat cgaggagttc     4380

cctgtgccag ccctgcacca cccagtgttc cagcaggaga gctttacccg ccaggtgctg     4440

tggaaactgc tgaaagtggt gaagttcgga gaggtcatca gctacagcca cctggccgcc     4500

ctggccggca atcccgccgc caccgccgcc gtgaaaaccg ccctgagcgg aaatcccgtg     4560

cccattctga tcccctgcca ccgggtggtg cagggcgacc tggacgtggg gggctacgag     4620

ggcgggctcg ccgtgaaaga gtggctgctg gcccacgagg gccacagact gggcaagcct     4680

gggctgggtg cggccgcact cgagcaccac caccaccacc ac                        4722


<210> 4
<211> 1574
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 4

Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Ala Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg Lys Arg  Tyr Thr Ser 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


Ser Arg  Ala Asp Pro Lys Lys  Lys Arg Lys Val Ala  Ser Met Asp 
    1370                 1375                 1380             


Lys Asp  Cys Glu Met Lys Arg  Thr Thr Leu Asp Ser  Pro Leu Gly 
    1385                 1390                 1395             


Lys Leu  Glu Leu Ser Gly Cys  Glu Gln Gly Leu His  Arg Ile Ile 
    1400                 1405                 1410             


Phe Leu  Gly Lys Gly Thr Ser  Ala Ala Asp Ala Val  Glu Val Pro 
    1415                 1420                 1425             


Ala Pro  Ala Ala Val Leu Gly  Gly Pro Glu Pro Leu  Met Gln Ala 
    1430                 1435                 1440             


Thr Ala  Trp Leu Asn Ala Tyr  Phe His Gln Pro Glu  Ala Ile Glu 
    1445                 1450                 1455             


Glu Phe  Pro Val Pro Ala Leu  His His Pro Val Phe  Gln Gln Glu 
    1460                 1465                 1470             


Ser Phe  Thr Arg Gln Val Leu  Trp Lys Leu Leu Lys  Val Val Lys 
    1475                 1480                 1485             


Phe Gly  Glu Val Ile Ser Tyr  Ser His Leu Ala Ala  Leu Ala Gly 
    1490                 1495                 1500             


Asn Pro  Ala Ala Thr Ala Ala  Val Lys Thr Ala Leu  Ser Gly Asn 
    1505                 1510                 1515             


Pro Val  Pro Ile Leu Ile Pro  Cys His Arg Val Val  Gln Gly Asp 
    1520                 1525                 1530             


Leu Asp  Val Gly Gly Tyr Glu  Gly Gly Leu Ala Val  Lys Glu Trp 
    1535                 1540                 1545             


Leu Leu  Ala His Glu Gly His  Arg Leu Gly Lys Pro  Gly Leu Gly 
    1550                 1555                 1560             


Ala Ala  Ala Leu Glu His His  His His His His 
    1565                 1570                 
