                         SEQUENCE LISTING

<110>  Yeda Research and Development Co. Ltd.
       FASS, Deborah
       GROSSMAN, Iris
       ILANI, Tal
 
<120>  ANTIBODIES TARGETING QUIESCIN SULFHYDRYL OXIDASE (QSOX1) AND USES
        OF SAME

<130>  67369

<150>  US 62/246,076
<151>  2015-10-25

<160>  51    

<170>  PatentIn version 3.5

<210>  1
<211>  3316
<212>  DNA
<213>  Homo sapiens

<400>  1
ggaggcaggc ggtgccgcgg cgccgggacc cgactcatcc ggtgcttgcg tgtggtggtg       60

agcgcagcgc cgaggatgag gaggtgcaac agcggctccg ggccgccgcc gtcgctgctg      120

ctgctgctgc tgtggctgct cgcggttccc ggcgctaacg cggccccgcg gtcggcgctc      180

tattcgcctt ccgacccgct gacgctgctg caggcggaca cggtgcgcgg cgcggtgctg      240

ggctcccgca gcgcctgggc cgtggagttc ttcgcctcct ggtgcggcca ctgcatcgcc      300

ttcgccccga cgtggaaggc gctggccgaa gacgtcaaag cctggaggcc ggccctgtat      360

ctcgccgccc tggactgtgc tgaggagacc aacagtgcag tctgcagaga cttcaacatc      420

cctggcttcc cgactgtgag gttcttcaag gcctttacca agaacggctc gggagcagta      480

tttccagtgg ctggtgctga cgtgcagaca ctgcgggaga ggctcattga cgccctggag      540

tcccatcatg acacgtggcc cccagcctgt cccccactgg agcctgccaa gctggaggag      600

attgatggat tctttgcgag aaataacgaa gagtacctgg ctctgatctt tgaaaaggga      660

ggctcctacc tgggtagaga ggtggctctg gacctgtccc agcacaaagg cgtggcggtg      720

cgcagggtgc tgaacacaga ggccaatgtg gtgagaaagt ttggtgtcac cgacttcccc      780

tcttgctacc tgctgttccg gaatggctct gtctcccgag tccccgtgct catggaatcc      840

aggtccttct ataccgctta cctgcagaga ctctctgggc tcaccaggga ggctgcccag      900

accacagttg caccaaccac tgctaacaag atagctccca ctgtttggaa attggcagat      960

cgctccaaga tctacatggc tgacctggaa tctgcactgc actacatcct gcggatagaa     1020

gtgggcaggt tcccggtcct ggaagggcag cgcctggtgg ccctgaaaaa gtttgtggca     1080

gtgctggcca agtatttccc tggccggccc ttagtccaga acttcctgca ctccgtgaat     1140

gaatggctca agaggcagaa gagaaataaa attccctaca gtttctttaa aactgccctg     1200

gacgacagga aagagggtgc cgttcttgcc aagaaggtga actggattgg ctgccagggg     1260

agtgagccgc atttccgggg ctttccctgc tccctgtggg tcctcttcca cttcttgact     1320

gtgcaggcag ctcggcaaaa tgtagaccac tcacaggaag cagccaaggc caaggaggtc     1380

ctcccagcca tccgaggcta cgtgcactac ttcttcggct gccgagactg cgctagccac     1440

ttcgagcaga tggctgctgc ctccatgcac cgggtgggga gtcccaacgc cgctgtcctc     1500

tggctctggt ctagccacaa cagggtcaat gctcgccttg caggtgcccc cagcgaggac     1560

ccccagttcc ccaaggtgca gtggccaccc cgtgaacttt gttctgcctg ccacaatgaa     1620

cgcctggatg tgcccgtgtg ggacgtggaa gccaccctca acttcctcaa ggcccacttc     1680

tccccaagca acatcatcct ggacttccct gcagctgggt cagctgcccg gagggatgtg     1740

cagaatgtgg cagccgcccc agagctggcg atgggagccc tggagctgga aagccggaat     1800

tcaactctgg accctgggaa gcctgagatg atgaagtccc ccacaaacac caccccacat     1860

gtgccggctg agggacctga ggcaagtcga cccccgaagc tgcaccctgg cctcagagct     1920

gcaccaggcc aggagcctcc tgagcacatg gcagagcttc agaggaatga gcaggagcag     1980

ccgcttgggc agtggcactt gagcaagcga gacacagggg ctgcattgct ggctgagtcc     2040

agggctgaga agaaccgcct ctggggccct ttggaggtca ggcgcgtggg ccgcagctcc     2100

aagcagctgg tcgacatccc tgagggccag ctggaggccc gagctggacg gggccgaggc     2160

cagtggctgc aggtgctggg agggggcttc tcttacctgg acatcagcct ctgtgtgggg     2220

ctctattccc tgtccttcat gggcctgctg gccatgtaca cctacttcca ggccaagata     2280

agggccctga agggccatgc tggccaccct gcagcctgaa ccacctgggg aggaggcggg     2340

agagggagct gccatctcta ggcacctcaa gccccctgac cccattccct cccctcccac     2400

cccttgctcc ttgtctggcc tagaagtgtg ggaaattcag gaaaacgagt tgctccagtg     2460

aagcttcttg gggttgctag gacagagagc tcctttgaca caaaagacag gagcagggtc     2520

caggttcccc tgctgtgcag ggagggcagc cccgggcagt gggcataggg cagctcagtc     2580

cctggcctct tagcaccaca ttcctgtttt tcagcttatt tgaagtcctg cctcattctc     2640

actggagcct cagtctctcc tgcttggtct tggccctcaa ctggggcaag tgaagccaga     2700

ggagggtccc ccagctgggt gggctggaat ggaactcctc actagctgct ggggctccgc     2760

ccaccctgct cccttccgga caatgaagaa gcctttgcac cctgggagga aggaccaccc     2820

cgggccctct atgcctggcc agcctccagc tcctcagacc tcctgggtgg ggtttggctt     2880

cagggtgggg tttggaagct tctggaagtc gtgctggtct cccaggtgag gcaagccatg     2940

gttgctgggc tgtagggtga gtggcttgct tggtgggacc tgacgagttg gtggcatggg     3000

aaggatgtgg gtctctagtg ccttgccctg gcttagctgc aggagaagat ggctgctttc     3060

acttcccccc attgagctct gctccctctg agcctggtct tttgtccttt tttattttgg     3120

tctccaagat gaatgctcat ctttggaggg tgccaggtag aagctaggga ggggagtgtc     3180

ttctctctcc aggtttcacc ttccagtgtg cagaagttag aagggtctgg cgggggcagt     3240

gccttacaca tgcttgattc ccacgctacc ccctgccttg ggaggtgtgt ggaataaatt     3300

atttttgtta aggcaa                                                     3316


<210>  2
<211>  2583
<212>  DNA
<213>  Homo sapiens

<400>  2
ggaggcaggc ggtgccgcgg cgccgggacc cgactcatcc ggtgcttgcg tgtggtggtg       60

agcgcagcgc cgaggatgag gaggtgcaac agcggctccg ggccgccgcc gtcgctgctg      120

ctgctgctgc tgtggctgct cgcggttccc ggcgctaacg cggccccgcg gtcggcgctc      180

tattcgcctt ccgacccgct gacgctgctg caggcggaca cggtgcgcgg cgcggtgctg      240

ggctcccgca gcgcctgggc cgtggagttc ttcgcctcct ggtgcggcca ctgcatcgcc      300

ttcgccccga cgtggaaggc gctggccgaa gacgtcaaag cctggaggcc ggccctgtat      360

ctcgccgccc tggactgtgc tgaggagacc aacagtgcag tctgcagaga cttcaacatc      420

cctggcttcc cgactgtgag gttcttcaag gcctttacca agaacggctc gggagcagta      480

tttccagtgg ctggtgctga cgtgcagaca ctgcgggaga ggctcattga cgccctggag      540

tcccatcatg acacgtggcc cccagcctgt cccccactgg agcctgccaa gctggaggag      600

attgatggat tctttgcgag aaataacgaa gagtacctgg ctctgatctt tgaaaaggga      660

ggctcctacc tgggtagaga ggtggctctg gacctgtccc agcacaaagg cgtggcggtg      720

cgcagggtgc tgaacacaga ggccaatgtg gtgagaaagt ttggtgtcac cgacttcccc      780

tcttgctacc tgctgttccg gaatggctct gtctcccgag tccccgtgct catggaatcc      840

aggtccttct ataccgctta cctgcagaga ctctctgggc tcaccaggga ggctgcccag      900

accacagttg caccaaccac tgctaacaag atagctccca ctgtttggaa attggcagat      960

cgctccaaga tctacatggc tgacctggaa tctgcactgc actacatcct gcggatagaa     1020

gtgggcaggt tcccggtcct ggaagggcag cgcctggtgg ccctgaaaaa gtttgtggca     1080

gtgctggcca agtatttccc tggccggccc ttagtccaga acttcctgca ctccgtgaat     1140

gaatggctca agaggcagaa gagaaataaa attccctaca gtttctttaa aactgccctg     1200

gacgacagga aagagggtgc cgttcttgcc aagaaggtga actggattgg ctgccagggg     1260

agtgagccgc atttccgggg ctttccctgc tccctgtggg tcctcttcca cttcttgact     1320

gtgcaggcag ctcggcaaaa tgtagaccac tcacaggaag cagccaaggc caaggaggtc     1380

ctcccagcca tccgaggcta cgtgcactac ttcttcggct gccgagactg cgctagccac     1440

ttcgagcaga tggctgctgc ctccatgcac cgggtgggga gtcccaacgc cgctgtcctc     1500

tggctctggt ctagccacaa cagggtcaat gctcgccttg caggtgcccc cagcgaggac     1560

ccccagttcc ccaaggtgca gtggccaccc cgtgaacttt gttctgcctg ccacaatgaa     1620

cgcctggatg tgcccgtgtg ggacgtggaa gccaccctca acttcctcaa ggcccacttc     1680

tccccaagca acatcatcct ggacttccct gcagctgggt cagctgcccg gagggatgtg     1740

cagaatgtgg cagccgcccc agagctggcg atgggagccc tggagctgga aagccggaat     1800

tcaactctgg accctgggaa gcctgagatg atgaagtccc ccacaaacac caccccacat     1860

gtgccggctg agggacctga gcttatttga agtcctgcct cattctcact ggagcctcag     1920

tctctcctgc ttggtcttgg ccctcaactg gggcaagtga agccagagga gggtccccca     1980

gctgggtggg ctggaatgga actcctcact agctgctggg gctccgccca ccctgctccc     2040

ttccggacaa tgaagaagcc tttgcaccct gggaggaagg accaccccgg gccctctatg     2100

cctggccagc ctccagctcc tcagacctcc tgggtggggt ttggcttcag ggtggggttt     2160

ggaagcttct ggaagtcgtg ctggtctccc aggtgaggca agccatggtt gctgggctgt     2220

agggtgagtg gcttgcttgg tgggacctga cgagttggtg gcatgggaag gatgtgggtc     2280

tctagtgcct tgccctggct tagctgcagg agaagatggc tgctttcact tccccccatt     2340

gagctctgct ccctctgagc ctggtctttt gtcctttttt attttggtct ccaagatgaa     2400

tgctcatctt tggagggtgc caggtagaag ctagggaggg gagtgtcttc tctctccagg     2460

tttcaccttc cagtgtgcag aagttagaag ggtctggcgg gggcagtgcc ttacacatgc     2520

ttgattccca cgctaccccc tgccttggga ggtgtgtgga ataaattatt tttgttaagg     2580

caa                                                                   2583


<210>  3
<211>  747
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Arg Arg Cys Asn Ser Gly Ser Gly Pro Pro Pro Ser Leu Leu Leu 
1               5                   10                  15      


Leu Leu Leu Trp Leu Leu Ala Val Pro Gly Ala Asn Ala Ala Pro Arg 
            20                  25                  30          


Ser Ala Leu Tyr Ser Pro Ser Asp Pro Leu Thr Leu Leu Gln Ala Asp 
        35                  40                  45              


Thr Val Arg Gly Ala Val Leu Gly Ser Arg Ser Ala Trp Ala Val Glu 
    50                  55                  60                  


Phe Phe Ala Ser Trp Cys Gly His Cys Ile Ala Phe Ala Pro Thr Trp 
65                  70                  75                  80  


Lys Ala Leu Ala Glu Asp Val Lys Ala Trp Arg Pro Ala Leu Tyr Leu 
                85                  90                  95      


Ala Ala Leu Asp Cys Ala Glu Glu Thr Asn Ser Ala Val Cys Arg Asp 
            100                 105                 110         


Phe Asn Ile Pro Gly Phe Pro Thr Val Arg Phe Phe Lys Ala Phe Thr 
        115                 120                 125             


Lys Asn Gly Ser Gly Ala Val Phe Pro Val Ala Gly Ala Asp Val Gln 
    130                 135                 140                 


Thr Leu Arg Glu Arg Leu Ile Asp Ala Leu Glu Ser His His Asp Thr 
145                 150                 155                 160 


Trp Pro Pro Ala Cys Pro Pro Leu Glu Pro Ala Lys Leu Glu Glu Ile 
                165                 170                 175     


Asp Gly Phe Phe Ala Arg Asn Asn Glu Glu Tyr Leu Ala Leu Ile Phe 
            180                 185                 190         


Glu Lys Gly Gly Ser Tyr Leu Gly Arg Glu Val Ala Leu Asp Leu Ser 
        195                 200                 205             


Gln His Lys Gly Val Ala Val Arg Arg Val Leu Asn Thr Glu Ala Asn 
    210                 215                 220                 


Val Val Arg Lys Phe Gly Val Thr Asp Phe Pro Ser Cys Tyr Leu Leu 
225                 230                 235                 240 


Phe Arg Asn Gly Ser Val Ser Arg Val Pro Val Leu Met Glu Ser Arg 
                245                 250                 255     


Ser Phe Tyr Thr Ala Tyr Leu Gln Arg Leu Ser Gly Leu Thr Arg Glu 
            260                 265                 270         


Ala Ala Gln Thr Thr Val Ala Pro Thr Thr Ala Asn Lys Ile Ala Pro 
        275                 280                 285             


Thr Val Trp Lys Leu Ala Asp Arg Ser Lys Ile Tyr Met Ala Asp Leu 
    290                 295                 300                 


Glu Ser Ala Leu His Tyr Ile Leu Arg Ile Glu Val Gly Arg Phe Pro 
305                 310                 315                 320 


Val Leu Glu Gly Gln Arg Leu Val Ala Leu Lys Lys Phe Val Ala Val 
                325                 330                 335     


Leu Ala Lys Tyr Phe Pro Gly Arg Pro Leu Val Gln Asn Phe Leu His 
            340                 345                 350         


Ser Val Asn Glu Trp Leu Lys Arg Gln Lys Arg Asn Lys Ile Pro Tyr 
        355                 360                 365             


Ser Phe Phe Lys Thr Ala Leu Asp Asp Arg Lys Glu Gly Ala Val Leu 
    370                 375                 380                 


Ala Lys Lys Val Asn Trp Ile Gly Cys Gln Gly Ser Glu Pro His Phe 
385                 390                 395                 400 


Arg Gly Phe Pro Cys Ser Leu Trp Val Leu Phe His Phe Leu Thr Val 
                405                 410                 415     


Gln Ala Ala Arg Gln Asn Val Asp His Ser Gln Glu Ala Ala Lys Ala 
            420                 425                 430         


Lys Glu Val Leu Pro Ala Ile Arg Gly Tyr Val His Tyr Phe Phe Gly 
        435                 440                 445             


Cys Arg Asp Cys Ala Ser His Phe Glu Gln Met Ala Ala Ala Ser Met 
    450                 455                 460                 


His Arg Val Gly Ser Pro Asn Ala Ala Val Leu Trp Leu Trp Ser Ser 
465                 470                 475                 480 


His Asn Arg Val Asn Ala Arg Leu Ala Gly Ala Pro Ser Glu Asp Pro 
                485                 490                 495     


Gln Phe Pro Lys Val Gln Trp Pro Pro Arg Glu Leu Cys Ser Ala Cys 
            500                 505                 510         


His Asn Glu Arg Leu Asp Val Pro Val Trp Asp Val Glu Ala Thr Leu 
        515                 520                 525             


Asn Phe Leu Lys Ala His Phe Ser Pro Ser Asn Ile Ile Leu Asp Phe 
    530                 535                 540                 


Pro Ala Ala Gly Ser Ala Ala Arg Arg Asp Val Gln Asn Val Ala Ala 
545                 550                 555                 560 


Ala Pro Glu Leu Ala Met Gly Ala Leu Glu Leu Glu Ser Arg Asn Ser 
                565                 570                 575     


Thr Leu Asp Pro Gly Lys Pro Glu Met Met Lys Ser Pro Thr Asn Thr 
            580                 585                 590         


Thr Pro His Val Pro Ala Glu Gly Pro Glu Ala Ser Arg Pro Pro Lys 
        595                 600                 605             


Leu His Pro Gly Leu Arg Ala Ala Pro Gly Gln Glu Pro Pro Glu His 
    610                 615                 620                 


Met Ala Glu Leu Gln Arg Asn Glu Gln Glu Gln Pro Leu Gly Gln Trp 
625                 630                 635                 640 


His Leu Ser Lys Arg Asp Thr Gly Ala Ala Leu Leu Ala Glu Ser Arg 
                645                 650                 655     


Ala Glu Lys Asn Arg Leu Trp Gly Pro Leu Glu Val Arg Arg Val Gly 
            660                 665                 670         


Arg Ser Ser Lys Gln Leu Val Asp Ile Pro Glu Gly Gln Leu Glu Ala 
        675                 680                 685             


Arg Ala Gly Arg Gly Arg Gly Gln Trp Leu Gln Val Leu Gly Gly Gly 
    690                 695                 700                 


Phe Ser Tyr Leu Asp Ile Ser Leu Cys Val Gly Leu Tyr Ser Leu Ser 
705                 710                 715                 720 


Phe Met Gly Leu Leu Ala Met Tyr Thr Tyr Phe Gln Ala Lys Ile Arg 
                725                 730                 735     


Ala Leu Lys Gly His Ala Gly His Pro Ala Ala 
            740                 745         


<210>  4
<211>  604
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Arg Arg Cys Asn Ser Gly Ser Gly Pro Pro Pro Ser Leu Leu Leu 
1               5                   10                  15      


Leu Leu Leu Trp Leu Leu Ala Val Pro Gly Ala Asn Ala Ala Pro Arg 
            20                  25                  30          


Ser Ala Leu Tyr Ser Pro Ser Asp Pro Leu Thr Leu Leu Gln Ala Asp 
        35                  40                  45              


Thr Val Arg Gly Ala Val Leu Gly Ser Arg Ser Ala Trp Ala Val Glu 
    50                  55                  60                  


Phe Phe Ala Ser Trp Cys Gly His Cys Ile Ala Phe Ala Pro Thr Trp 
65                  70                  75                  80  


Lys Ala Leu Ala Glu Asp Val Lys Ala Trp Arg Pro Ala Leu Tyr Leu 
                85                  90                  95      


Ala Ala Leu Asp Cys Ala Glu Glu Thr Asn Ser Ala Val Cys Arg Asp 
            100                 105                 110         


Phe Asn Ile Pro Gly Phe Pro Thr Val Arg Phe Phe Lys Ala Phe Thr 
        115                 120                 125             


Lys Asn Gly Ser Gly Ala Val Phe Pro Val Ala Gly Ala Asp Val Gln 
    130                 135                 140                 


Thr Leu Arg Glu Arg Leu Ile Asp Ala Leu Glu Ser His His Asp Thr 
145                 150                 155                 160 


Trp Pro Pro Ala Cys Pro Pro Leu Glu Pro Ala Lys Leu Glu Glu Ile 
                165                 170                 175     


Asp Gly Phe Phe Ala Arg Asn Asn Glu Glu Tyr Leu Ala Leu Ile Phe 
            180                 185                 190         


Glu Lys Gly Gly Ser Tyr Leu Gly Arg Glu Val Ala Leu Asp Leu Ser 
        195                 200                 205             


Gln His Lys Gly Val Ala Val Arg Arg Val Leu Asn Thr Glu Ala Asn 
    210                 215                 220                 


Val Val Arg Lys Phe Gly Val Thr Asp Phe Pro Ser Cys Tyr Leu Leu 
225                 230                 235                 240 


Phe Arg Asn Gly Ser Val Ser Arg Val Pro Val Leu Met Glu Ser Arg 
                245                 250                 255     


Ser Phe Tyr Thr Ala Tyr Leu Gln Arg Leu Ser Gly Leu Thr Arg Glu 
            260                 265                 270         


Ala Ala Gln Thr Thr Val Ala Pro Thr Thr Ala Asn Lys Ile Ala Pro 
        275                 280                 285             


Thr Val Trp Lys Leu Ala Asp Arg Ser Lys Ile Tyr Met Ala Asp Leu 
    290                 295                 300                 


Glu Ser Ala Leu His Tyr Ile Leu Arg Ile Glu Val Gly Arg Phe Pro 
305                 310                 315                 320 


Val Leu Glu Gly Gln Arg Leu Val Ala Leu Lys Lys Phe Val Ala Val 
                325                 330                 335     


Leu Ala Lys Tyr Phe Pro Gly Arg Pro Leu Val Gln Asn Phe Leu His 
            340                 345                 350         


Ser Val Asn Glu Trp Leu Lys Arg Gln Lys Arg Asn Lys Ile Pro Tyr 
        355                 360                 365             


Ser Phe Phe Lys Thr Ala Leu Asp Asp Arg Lys Glu Gly Ala Val Leu 
    370                 375                 380                 


Ala Lys Lys Val Asn Trp Ile Gly Cys Gln Gly Ser Glu Pro His Phe 
385                 390                 395                 400 


Arg Gly Phe Pro Cys Ser Leu Trp Val Leu Phe His Phe Leu Thr Val 
                405                 410                 415     


Gln Ala Ala Arg Gln Asn Val Asp His Ser Gln Glu Ala Ala Lys Ala 
            420                 425                 430         


Lys Glu Val Leu Pro Ala Ile Arg Gly Tyr Val His Tyr Phe Phe Gly 
        435                 440                 445             


Cys Arg Asp Cys Ala Ser His Phe Glu Gln Met Ala Ala Ala Ser Met 
    450                 455                 460                 


His Arg Val Gly Ser Pro Asn Ala Ala Val Leu Trp Leu Trp Ser Ser 
465                 470                 475                 480 


His Asn Arg Val Asn Ala Arg Leu Ala Gly Ala Pro Ser Glu Asp Pro 
                485                 490                 495     


Gln Phe Pro Lys Val Gln Trp Pro Pro Arg Glu Leu Cys Ser Ala Cys 
            500                 505                 510         


His Asn Glu Arg Leu Asp Val Pro Val Trp Asp Val Glu Ala Thr Leu 
        515                 520                 525             


Asn Phe Leu Lys Ala His Phe Ser Pro Ser Asn Ile Ile Leu Asp Phe 
    530                 535                 540                 


Pro Ala Ala Gly Ser Ala Ala Arg Arg Asp Val Gln Asn Val Ala Ala 
545                 550                 555                 560 


Ala Pro Glu Leu Ala Met Gly Ala Leu Glu Leu Glu Ser Arg Asn Ser 
                565                 570                 575     


Thr Leu Asp Pro Gly Lys Pro Glu Met Met Lys Ser Pro Thr Asn Thr 
            580                 585                 590         


Thr Pro His Val Pro Ala Glu Gly Pro Glu Leu Ile 
        595                 600                 


<210>  5
<211>  604
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Arg Arg Cys Asn Ser Gly Ser Gly Pro Pro Pro Ser Leu Leu Leu 
1               5                   10                  15      


Leu Leu Leu Trp Leu Leu Ala Val Pro Gly Ala Asn Ala Ala Pro Arg 
            20                  25                  30          


Ser Ala Leu Tyr Ser Pro Ser Asp Pro Leu Thr Leu Leu Gln Ala Asp 
        35                  40                  45              


Thr Val Arg Gly Ala Val Leu Gly Ser Arg Ser Ala Trp Ala Val Glu 
    50                  55                  60                  


Phe Phe Ala Ser Trp Cys Gly His Cys Ile Ala Phe Ala Pro Thr Trp 
65                  70                  75                  80  


Lys Ala Leu Ala Glu Asp Val Lys Ala Trp Arg Pro Ala Leu Tyr Leu 
                85                  90                  95      


Ala Ala Leu Asp Cys Ala Glu Glu Thr Asn Ser Ala Val Cys Arg Asp 
            100                 105                 110         


Phe Asn Ile Pro Gly Phe Pro Thr Val Arg Phe Phe Lys Ala Phe Thr 
        115                 120                 125             


Lys Asn Gly Ser Gly Ala Val Phe Pro Val Ala Gly Ala Asp Val Gln 
    130                 135                 140                 


Thr Leu Arg Glu Arg Leu Ile Asp Ala Leu Glu Ser His His Asp Thr 
145                 150                 155                 160 


Trp Pro Pro Ala Cys Pro Pro Leu Glu Pro Ala Lys Leu Glu Glu Ile 
                165                 170                 175     


Asp Gly Phe Phe Ala Arg Asn Asn Glu Glu Tyr Leu Ala Leu Ile Phe 
            180                 185                 190         


Glu Lys Gly Gly Ser Tyr Leu Gly Arg Glu Val Ala Leu Asp Leu Ser 
        195                 200                 205             


Gln His Lys Gly Val Ala Val Arg Arg Val Leu Asn Thr Glu Ala Asn 
    210                 215                 220                 


Val Val Arg Lys Phe Gly Val Thr Asp Phe Pro Ser Cys Tyr Leu Leu 
225                 230                 235                 240 


Phe Arg Asn Gly Ser Val Ser Arg Val Pro Val Leu Met Glu Ser Arg 
                245                 250                 255     


Ser Phe Tyr Thr Ala Tyr Leu Gln Arg Leu Ser Gly Leu Thr Arg Glu 
            260                 265                 270         


Ala Ala Gln Thr Thr Val Ala Pro Thr Thr Ala Asn Lys Ile Ala Pro 
        275                 280                 285             


Thr Val Trp Lys Leu Ala Asp Arg Ser Lys Ile Tyr Met Ala Asp Leu 
    290                 295                 300                 


Glu Ser Ala Leu His Tyr Ile Leu Arg Ile Glu Val Gly Arg Phe Pro 
305                 310                 315                 320 


Val Leu Glu Gly Gln Arg Leu Val Ala Leu Lys Lys Phe Val Ala Val 
                325                 330                 335     


Leu Ala Lys Tyr Phe Pro Gly Arg Pro Leu Val Gln Asn Phe Leu His 
            340                 345                 350         


Ser Val Asn Glu Trp Leu Lys Arg Gln Lys Arg Asn Lys Ile Pro Tyr 
        355                 360                 365             


Ser Phe Phe Lys Thr Ala Leu Asp Asp Arg Lys Glu Gly Ala Val Leu 
    370                 375                 380                 


Ala Lys Lys Val Asn Trp Ile Gly Cys Gln Gly Ser Glu Pro His Phe 
385                 390                 395                 400 


Arg Gly Phe Pro Cys Ser Leu Trp Val Leu Phe His Phe Leu Thr Val 
                405                 410                 415     


Gln Ala Ala Arg Gln Asn Val Asp His Ser Gln Glu Ala Ala Lys Ala 
            420                 425                 430         


Lys Glu Val Leu Pro Ala Ile Arg Gly Tyr Val His Tyr Phe Phe Gly 
        435                 440                 445             


Cys Arg Asp Cys Ala Ser His Phe Glu Gln Met Ala Ala Ala Ser Met 
    450                 455                 460                 


His Arg Val Gly Ser Pro Asn Ala Ala Val Leu Trp Leu Trp Ser Ser 
465                 470                 475                 480 


His Asn Arg Val Asn Ala Arg Leu Ala Gly Ala Pro Ser Glu Asp Pro 
                485                 490                 495     


Gln Phe Pro Lys Val Gln Trp Pro Pro Arg Glu Leu Cys Ser Ala Cys 
            500                 505                 510         


His Asn Glu Arg Leu Asp Val Pro Val Trp Asp Val Glu Ala Thr Leu 
        515                 520                 525             


Asn Phe Leu Lys Ala His Phe Ser Pro Ser Asn Ile Ile Leu Asp Phe 
    530                 535                 540                 


Pro Ala Ala Gly Ser Ala Ala Arg Arg Asp Val Gln Asn Val Ala Ala 
545                 550                 555                 560 


Ala Pro Glu Leu Ala Met Gly Ala Leu Glu Leu Glu Ser Arg Asn Ser 
                565                 570                 575     


Thr Leu Asp Pro Gly Lys Pro Glu Met Met Lys Ser Pro Thr Asn Thr 
            580                 585                 590         


Thr Pro His Val Pro Ala Glu Gly Pro Glu Leu Ile 
        595                 600                 


<210>  6
<211>  748
<212>  PRT
<213>  Mus musculus

<400>  6

Met Arg Arg Cys Gly Arg Leu Ser Gly Pro Pro Ser Leu Leu Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Ser Pro Leu Leu Phe Ser Gly Pro Gly Ala Tyr Ala 
            20                  25                  30          


Ala Arg Leu Ser Val Leu Tyr Ser Ser Ser Asp Pro Leu Thr Leu Leu 
        35                  40                  45              


Asp Ala Asp Ser Val Arg Pro Thr Val Leu Gly Ser Ser Ser Ala Trp 
    50                  55                  60                  


Ala Val Glu Phe Phe Ala Ser Trp Cys Gly His Cys Ile Ala Phe Ala 
65                  70                  75                  80  


Pro Thr Trp Lys Glu Leu Ala Asn Asp Val Lys Asp Trp Arg Pro Ala 
                85                  90                  95      


Leu Asn Leu Ala Val Leu Asp Cys Ala Glu Glu Thr Asn Ser Ala Val 
            100                 105                 110         


Cys Arg Glu Phe Asn Ile Ala Gly Phe Pro Thr Val Arg Phe Phe Gln 
        115                 120                 125             


Ala Phe Thr Lys Asn Gly Ser Gly Ala Thr Leu Pro Gly Ala Gly Ala 
    130                 135                 140                 


Asn Val Gln Thr Leu Arg Met Arg Leu Ile Asp Ala Leu Glu Ser His 
145                 150                 155                 160 


Arg Asp Thr Trp Pro Pro Ala Cys Pro Pro Leu Glu Pro Ala Lys Leu 
                165                 170                 175     


Asn Asp Ile Asp Gly Phe Phe Thr Arg Asn Lys Ala Asp Tyr Leu Ala 
            180                 185                 190         


Leu Val Phe Glu Arg Glu Asp Ser Tyr Leu Gly Arg Glu Val Thr Leu 
        195                 200                 205             


Asp Leu Ser Gln Tyr His Ala Val Ala Val Arg Arg Val Leu Asn Thr 
    210                 215                 220                 


Glu Ser Asp Leu Val Asn Lys Phe Gly Val Thr Asp Phe Pro Ser Cys 
225                 230                 235                 240 


Tyr Leu Leu Leu Arg Asn Gly Ser Val Ser Arg Val Pro Val Leu Val 
                245                 250                 255     


Glu Ser Arg Ser Phe Tyr Thr Ser Tyr Leu Arg Gly Leu Pro Gly Leu 
            260                 265                 270         


Thr Arg Asp Ala Pro Pro Thr Thr Ala Thr Pro Val Thr Ala Asp Lys 
        275                 280                 285             


Ile Ala Pro Thr Val Trp Lys Phe Ala Asp Arg Ser Lys Ile Tyr Met 
    290                 295                 300                 


Ala Asp Leu Glu Ser Ala Leu His Tyr Ile Leu Arg Val Glu Val Gly 
305                 310                 315                 320 


Lys Phe Ser Val Leu Glu Gly Gln Arg Leu Val Ala Leu Lys Lys Phe 
                325                 330                 335     


Val Ala Val Leu Ala Lys Tyr Phe Pro Gly Gln Pro Leu Val Gln Asn 
            340                 345                 350         


Phe Leu His Ser Ile Asn Asp Trp Leu Gln Lys Gln Gln Lys Lys Arg 
        355                 360                 365             


Ile Pro Tyr Ser Phe Phe Lys Ala Ala Leu Asp Ser Arg Lys Glu Asp 
    370                 375                 380                 


Ala Val Leu Thr Glu Lys Val Asn Trp Val Gly Cys Gln Gly Ser Glu 
385                 390                 395                 400 


Pro His Phe Arg Gly Phe Pro Cys Ser Leu Trp Val Leu Phe His Phe 
                405                 410                 415     


Leu Thr Val Gln Ala Asn Arg Tyr Ser Glu Ala His Pro Gln Glu Pro 
            420                 425                 430         


Ala Asp Gly Gln Glu Val Leu Gln Ala Met Arg Ser Tyr Val Gln Phe 
        435                 440                 445             


Phe Phe Gly Cys Arg Asp Cys Ala Asp His Phe Glu Gln Met Ala Ala 
    450                 455                 460                 


Ala Ser Met His Gln Val Arg Ser Pro Ser Asn Ala Ile Leu Trp Leu 
465                 470                 475                 480 


Trp Thr Ser His Asn Arg Val Asn Ala Arg Leu Ser Gly Ala Leu Ser 
                485                 490                 495     


Glu Asp Pro His Phe Pro Lys Val Gln Trp Pro Pro Arg Glu Leu Cys 
            500                 505                 510         


Ser Ala Cys His Asn Glu Leu Asn Gly Gln Val Pro Leu Trp Asp Leu 
        515                 520                 525             


Gly Ala Thr Leu Asn Phe Leu Lys Ala His Phe Ser Pro Ala Asn Ile 
    530                 535                 540                 


Val Ile Asp Ser Ser Ala Ser Arg His Thr Gly Arg Arg Gly Ser Pro 
545                 550                 555                 560 


Glu Ala Thr Pro Glu Leu Val Met Asp Thr Leu Lys Leu Glu Ser Arg 
                565                 570                 575     


Asn Ser Val Leu Gly His Glu Gln Ala Ala Ser Ala Glu Ser Pro Gly 
            580                 585                 590         


Ala Thr Ala Leu Asp Val Pro Ala Glu Lys Pro Glu Ala Ser Gly Pro 
        595                 600                 605             


Gln Glu Leu Tyr Thr Gly Leu Arg Met Gly Gly Ala Ser Pro Gly Gln 
    610                 615                 620                 


Gly Pro Pro Glu Arg Met Glu Asp His Gln Arg Asp Met Gln Glu Asn 
625                 630                 635                 640 


Ala Pro Gly Gln Gln His Leu Ser Lys Arg Asp Thr Glu Ala Leu Phe 
                645                 650                 655     


Leu Pro Glu Val Asn His Leu Gln Gly Pro Leu Glu Leu Arg Arg Gly 
            660                 665                 670         


Gly Arg Ser Pro Lys Gln Leu Ala Pro Ile Leu Glu Glu Glu Pro Glu 
        675                 680                 685             


Ala Leu Ala Ile Gln Gly Gln Gly Gln Trp Leu Gln Val Leu Gly Gly 
    690                 695                 700                 


Gly Ile Ser His Leu Asp Ile Ser Leu Cys Val Gly Leu Tyr Ser Val 
705                 710                 715                 720 


Ser Phe Met Gly Leu Leu Ala Met Tyr Thr Tyr Phe Arg Ala Arg Leu 
                725                 730                 735     


Arg Thr Pro Lys Gly His Ala Ser Tyr Pro Thr Ala 
            740                 745             


<210>  7
<211>  750
<212>  PRT
<213>  Rattus norvegicus

<400>  7

Met Arg Arg Cys Gly Arg His Ser Gly Pro Pro Ser Leu Leu Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Pro Pro Leu Leu Leu Ser Val Pro Gly Ala Tyr Ala 
            20                  25                  30          


Ala Arg Leu Ser Val Leu Tyr Ser Ser Ser Asp Pro Leu Thr Leu Leu 
        35                  40                  45              


Asp Ala Asp Thr Val Arg Pro Ala Val Leu Gly Ser Ser Ser Ala Trp 
    50                  55                  60                  


Ala Val Glu Phe Phe Ala Ser Trp Cys Gly His Cys Ile Ala Phe Ala 
65                  70                  75                  80  


Pro Thr Trp Lys Glu Leu Ala Asn Asp Val Lys Asp Trp Arg Pro Ala 
                85                  90                  95      


Leu Asn Leu Ala Val Leu Asp Cys Ala Asp Glu Thr Asn Ser Ala Val 
            100                 105                 110         


Cys Arg Glu Phe Asn Ile Ala Gly Phe Pro Thr Val Arg Phe Phe Lys 
        115                 120                 125             


Ala Phe Ser Lys Asn Gly Thr Gly Thr Ala Leu Pro Ala Ala Gly Ala 
    130                 135                 140                 


Asn Val Gln Thr Leu Arg Met Arg Leu Ile Asp Ala Leu Glu Ser His 
145                 150                 155                 160 


Arg Asp Thr Trp Pro Pro Ala Cys Pro Pro Leu Glu Pro Ala Lys Leu 
                165                 170                 175     


Lys Asp Ile Asn Glu Phe Phe Thr Arg Ser Lys Ala Glu Tyr Leu Ala 
            180                 185                 190         


Leu Ile Phe Glu Arg Glu Asp Ser Tyr Leu Gly Arg Glu Val Thr Leu 
        195                 200                 205             


Asp Leu Ser Gln Phe His Ala Val Ala Val Arg Arg Val Leu Asn Ser 
    210                 215                 220                 


Glu Ser Asp Val Val Ser Lys Phe Ala Val Thr Asp Phe Pro Ser Cys 
225                 230                 235                 240 


Tyr Leu Leu Leu Arg Asn Gly Ser Val Ser Arg Val Pro Val Leu Val 
                245                 250                 255     


Glu Ser Arg Pro Phe Tyr Thr Ser Tyr Leu Arg Gly Leu Pro Gly Leu 
            260                 265                 270         


Thr Arg Glu Ala Pro Pro Thr Thr Ala Ala Pro Val Thr Pro Asp Lys 
        275                 280                 285             


Ile Ala Pro Thr Val Trp Lys Phe Ala Asp Arg Ser Lys Ile Tyr Met 
    290                 295                 300                 


Ala Asp Leu Glu Ser Ala Leu His Tyr Ile Leu Arg Val Glu Val Gly 
305                 310                 315                 320 


Lys Phe Ser Val Leu Glu Gly Gln Arg Leu Val Ala Leu Lys Lys Phe 
                325                 330                 335     


Val Ala Val Leu Ala Lys Tyr Phe Pro Gly Gln Pro Leu Val Gln Asn 
            340                 345                 350         


Phe Leu His Ser Ile Asn Asp Trp Leu Gln Lys Gln Gln Lys Lys Lys 
        355                 360                 365             


Ile Pro Tyr Ser Tyr Phe Lys Ala Ala Leu Asp Ser Arg Lys Glu Asn 
    370                 375                 380                 


Ala Val Leu Ala Glu Lys Val Asn Trp Ile Gly Cys Gln Gly Ser Glu 
385                 390                 395                 400 


Pro His Phe Arg Gly Phe Pro Cys Ser Leu Trp Val Leu Phe His Phe 
                405                 410                 415     


Leu Thr Val Gln Ala His Arg Tyr Ser Glu Ala His Pro Gln Glu Pro 
            420                 425                 430         


Ala Asp Gly Gln Glu Val Leu Gln Ala Met Arg Ser Tyr Val Gln Ser 
        435                 440                 445             


Phe Phe Gly Cys Arg Asp Cys Ala Asn His Phe Glu Gln Met Ala Ala 
    450                 455                 460                 


Ala Ser Met His Gln Val Lys Ser Pro Ser Asn Ala Val Leu Trp Leu 
465                 470                 475                 480 


Trp Thr Ser His Asn Arg Val Asn Ala Arg Leu Ser Gly Ala Leu Ser 
                485                 490                 495     


Glu Asp Pro Gln Phe Pro Lys Val Gln Trp Pro Pro Arg Glu Leu Cys 
            500                 505                 510         


Ser Ala Cys His Asn Glu Val Asn Gly Gln Val Pro Leu Trp Asp Leu 
        515                 520                 525             


Gly Ala Thr Leu Asn Phe Leu Lys Ala His Phe Ser Pro Ala Asn Ile 
    530                 535                 540                 


Val Arg Asp Pro Pro Ala Pro Gly Pro Ala Ser Arg Arg Gly Thr Gln 
545                 550                 555                 560 


Asp Pro Glu Ala Ser Pro Asn Leu Val Met Asp Thr Leu Lys Leu Glu 
                565                 570                 575     


Thr Gly Asn Ser Val Leu Gly His Glu Gln Ala Ala Ser Ala Ala Ser 
            580                 585                 590         


Pro Gly Ala Thr Ala Leu Asp Val Pro Ala Gly Lys Pro Glu Ala Ser 
        595                 600                 605             


Gly Pro Gln Glu Leu Asn Ala Gly Leu Ser Met Gly Gly Ala Ser Pro 
    610                 615                 620                 


Gly Gln Gly Pro Pro Glu His Thr Glu Glu Leu Leu Arg Asp Val Gln 
625                 630                 635                 640 


Glu Asn Ala Gln Gly Gln Gln His Leu Ser Lys Arg Asp Thr Glu Ala 
                645                 650                 655     


Leu Leu Leu Pro Glu Val Asn His Leu Gln Gly Pro Leu Ala Pro Arg 
            660                 665                 670         


Arg Gly Gly His Ser Pro Lys Gln Leu Ala Ser Ile Leu Glu Gly Glu 
        675                 680                 685             


Pro Glu Ala Leu Ala Ile Gln Gly Arg Arg Gln Trp Leu Gln Val Leu 
    690                 695                 700                 


Gly Gly Gly Val Ser Phe Leu Asp Ile Ser Leu Cys Val Gly Leu Tyr 
705                 710                 715                 720 


Ser Val Ser Phe Met Gly Leu Leu Ala Met Tyr Thr Tyr Phe Arg Ala 
                725                 730                 735     


Arg Met Arg Thr Pro Lys Gly His Val Ser Tyr Pro Thr Ala 
            740                 745                 750 


<210>  8
<211>  613
<212>  PRT
<213>  Cavia porcellus

<400>  8

Met Thr Gly Cys Gly Arg Arg Ser Gly Trp Leu Pro Pro Leu Arg Leu 
1               5                   10                  15      


Leu Leu Leu Pro Leu Leu Leu Gly Gly Pro Gly Val Gly Ala Ala Gln 
            20                  25                  30          


Leu Ala Ala Leu Tyr Ser Ala Ser Asp Pro Leu Thr Leu Leu Gln Ala 
        35                  40                  45              


Asp Thr Val Arg Ser Thr Val Leu Asn Ser Pro Ser Ala Trp Ala Val 
    50                  55                  60                  


Glu Phe Phe Ala Ser Trp Cys Gly His Cys Ile Ala Phe Ala Pro Thr 
65                  70                  75                  80  


Trp Lys Ala Leu Ala Lys Asp Ile Lys Asp Trp Arg Pro Ala Leu Asn 
                85                  90                  95      


Leu Ala Ala Leu Asn Cys Ala Asp Glu Thr Asn Asn Ala Val Cys Arg 
            100                 105                 110         


Asp Phe Asn Ile Ala Gly Phe Pro Ser Val Arg Phe Phe Lys Ala Phe 
        115                 120                 125             


Ser Lys Asn Ser Thr Gly Thr Thr Leu Pro Val Ala Gly Ala Asn Val 
    130                 135                 140                 


Gln Met Leu Arg Glu Arg Leu Ile Asp Ala Leu Glu Ser His His Asp 
145                 150                 155                 160 


Thr Trp Pro Ser Ala Cys Pro Pro Leu Glu Pro Val Lys Pro Lys Glu 
                165                 170                 175     


Ile Asp Thr Phe Phe Ala Arg Asn Asn Gln Glu Tyr Leu Val Leu Ile 
            180                 185                 190         


Phe Glu Gln Glu Asn Ser Tyr Leu Gly Arg Glu Val Thr Leu Asp Leu 
        195                 200                 205             


Ser Gln His His Asp Leu Val Val Arg Arg Val Leu Ser Thr Glu Ala 
    210                 215                 220                 


Asn Val Val Arg Lys Phe Gly Val Ala Asp Phe Pro Ser Cys Tyr Leu 
225                 230                 235                 240 


Leu Phe Arg Asn Gly Ser Val Ser Arg Val Pro Val Leu Val Glu Ser 
                245                 250                 255     


Arg Arg Phe Tyr Thr Ala Tyr Leu Gln Arg Leu Ser Glu Val Thr Arg 
            260                 265                 270         


Glu Gly Thr Pro Thr Pro Ala Val Pro Thr Ile Ser Asp Gln Ile Ala 
        275                 280                 285             


Pro Thr Val Trp Lys Phe Ala Asp Arg Ser Lys Ile Tyr Met Ala Asp 
    290                 295                 300                 


Leu Glu Ser Ala Leu His Tyr Ile Leu Arg Val Glu Val Gly Arg Phe 
305                 310                 315                 320 


Ser Val Leu Glu Gly Gln Arg Leu Met Ala Leu Lys Lys Phe Val Thr 
                325                 330                 335     


Val Leu Thr Lys Tyr Phe Pro Gly Gln Pro Leu Val Arg Asn Phe Leu 
            340                 345                 350         


Gln Ser Thr Asn Glu Trp Leu Lys Arg Gln His Lys Lys Lys Met Pro 
        355                 360                 365             


Tyr Ser Phe Phe Lys Thr Ala Met Asp Ser Arg Asn Glu Glu Ala Val 
    370                 375                 380                 


Ile Thr Lys Glu Val Asn Trp Val Gly Cys Gln Gly Ser Glu Ser His 
385                 390                 395                 400 


Phe Arg Gly Phe Pro Cys Ser Leu Trp Ile Leu Phe His Phe Leu Thr 
                405                 410                 415     


Val Gln Ala Ser Gln Lys Asn Ala Glu Ser Ser Gln Lys Pro Ala Asn 
            420                 425                 430         


Gly Gln Glu Val Leu Gln Ala Ile Arg Asn Tyr Val Arg Phe Phe Phe 
        435                 440                 445             


Gly Cys Arg Asp Cys Ala Asn His Phe Glu Gln Met Ala Ala Gly Ser 
    450                 455                 460                 


Met His Arg Val Lys Ser Pro Asn Asp Ala Val Leu Trp Leu Trp Thr 
465                 470                 475                 480 


Ser His Asn Arg Val Asn Ala Arg Leu Ala Gly Ala Pro Ser Glu Asp 
                485                 490                 495     


Pro Gln Phe Pro Lys Val Gln Trp Pro Pro Pro Glu Leu Cys Ser Ala 
            500                 505                 510         


Cys His Asn Glu Leu Ser Gly Glu Pro Val Trp Asp Val Asp Ala Thr 
        515                 520                 525             


Leu Arg Phe Leu Lys Thr His Phe Ser Pro Ser Asn Ile Val Leu Asn 
    530                 535                 540                 


Phe Pro Pro Ala Glu Pro Ala Ser Arg Ser Ser Val His Ser Trp Gly 
545                 550                 555                 560 


Ala Thr Pro His Leu Glu Leu Asp Ala Leu Gly Leu Val Thr Arg Asn 
                565                 570                 575     


Ser Ala Leu Ala Leu Glu Arg Ala Glu Ile Ser Glu Ser Pro Gly Ser 
            580                 585                 590         


Asn Ala Met Pro Asn Ile Pro Ala Glu Arg Pro Glu Leu Phe Glu Ala 
        595                 600                 605             


Leu Ser His Ser Arg 
    610             


<210>  9
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MAb316.1 variable region - light chain

<400>  9

Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Ile Ser Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Tyr Trp Tyr His Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr 
        35                  40                  45              


Arg Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Tyr His Ser Tyr Pro Leu Thr 
                85                  90                  95      


Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105     


<210>  10
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MAb316.1 variable region - heavy chain

<400>  10

Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Ile His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Tyr Pro Gly Ser Tyr Asn Thr Glu Tyr Ser Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Thr Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Glu Asp Trp Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser 
        115 


<210>  11
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MAb316.1 variable  region partial sequences    (light chain)

<400>  11

Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys 
        


<210>  12
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MAb316.1 variable  region partial sequences    (light chain)

<400>  12

Val Thr Ile Ser Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Tyr Trp 
1               5                   10                  15      


Tyr His Gln Lys Pro Gly Ser Ser Pro Lys 
            20                  25      


<210>  13
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MAb316.1 variable  region partial sequences    (light chain)

<400>  13

Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg 
1               5                   10      


<210>  14
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MAb316.1 variable  region partial sequences    (light chain)

<400>  14

Thr Ile Ser Ser Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln 
1               5                   10                  15      


Gln Tyr His Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys 
            20                  25                  30  


<210>  15
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MAb316.1 variable  region partial sequences    (light chain)

<400>  15

Ile Tyr Arg Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe 
1               5                   10                  15  


<210>  16
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MAb316.1 variable  region partial sequences    (light chain)

<400>  16

Arg Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe 
1               5                   10              


<210>  17
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MAb316.1 variable  region partial sequences    (light chain)

<400>  17

Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser 
1               5                   10                  15      


Tyr 
    


<210>  18
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MAb316.1 variable  region partial sequences    (light chain)

<400>  18

Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 
1               5                   10  


<210>  19
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MAb316.1 variable region partial sequences (heavy chain)

<400>  19

Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys 
            


<210>  20
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MAb316.1 variable region partial sequences (heavy chain)

<400>  20

Ala Ser Gly Tyr Ser Phe Thr Ser Tyr Tyr Ile His Trp Val Lys 
1               5                   10                  15  


<210>  21
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MAb316.1 variable region partial sequences (heavy chain)

<400>  21

Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly Trp Ile Tyr Pro Gly 
1               5                   10                  15      


Ser Tyr Asn Thr Glu Tyr Ser Glu Lys 
            20                  25  


<210>  22
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MAb316.1 variable region partial sequences (heavy chain)

<400>  22

Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
1               5                   10                  15      


Ala Arg 
        


<210>  23
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MAb316.1 variable region partial sequences (heavy chain)

<400>  23

Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala Ser Val Lys Ile 
1               5                   10                  15      


Ser Cys Lys Ala Ser Gly Tyr 
            20              


<210>  24
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MAb316.1 variable region partial sequences (heavy chain)

<400>  24

Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly Trp 
1               5                   10                  


<210>  25
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MAb316.1 variable region partial sequences (heavy chain)

<400>  25

Pro Gly Ser Tyr Asn Thr Glu Tyr Ser Glu Lys Phe 
1               5                   10          


<210>  26
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MAb316.1 light chain CDR1 amino acid sequence

<400>  26

Ser Ser Val Ser Tyr 
1               5   


<210>  27
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MAb316.1 light chain CDR2 amino acid sequence

<400>  27

Arg Thr Ser 
1           


<210>  28
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MAb316.1 light chain CDR3 amino acid sequence

<400>  28

Gln Gln Tyr His Ser Tyr Pro Leu Thr 
1               5                   


<210>  29
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MAb316.1 heavy chain CDR1 amino acid sequence

<400>  29

Gly Tyr Ser Phe Thr Ser Tyr Tyr 
1               5               


<210>  30
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MAb316.1 heavy chain CDR2 amino acid sequence

<400>  30

Ile Tyr Pro Gly Ser Tyr Asn Thr 
1               5               


<210>  31
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MAb316.1 heavy chain CDR3 amino acid sequence

<400>  31

Ala Arg Ser Glu Asp Trp Phe Ala Tyr 
1               5                   


<210>  32
<211>  748
<212>  PRT
<213>  Homo sapiens

<400>  32

Met Arg Arg Cys Gly Arg Leu Ser Gly Pro Pro Ser Leu Leu Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Ser Pro Leu Leu Phe Ser Gly Pro Gly Ala Tyr Ala 
            20                  25                  30          


Ala Arg Leu Ser Val Leu Tyr Ser Ser Ser Asp Pro Leu Thr Leu Leu 
        35                  40                  45              


Asp Ala Asp Ser Val Arg Pro Thr Val Leu Gly Ser Ser Ser Ala Trp 
    50                  55                  60                  


Ala Val Glu Phe Phe Ala Ser Trp Cys Gly His Cys Ile Ala Phe Ala 
65                  70                  75                  80  


Pro Thr Trp Lys Glu Leu Ala Asn Asp Val Lys Asp Trp Arg Pro Ala 
                85                  90                  95      


Leu Asn Leu Ala Val Leu Asp Cys Ala Glu Glu Thr Asn Ser Ala Val 
            100                 105                 110         


Cys Arg Glu Phe Asn Ile Ala Gly Phe Pro Thr Val Arg Phe Phe Gln 
        115                 120                 125             


Ala Phe Thr Lys Asn Gly Ser Gly Ala Thr Leu Pro Gly Ala Gly Ala 
    130                 135                 140                 


Asn Val Gln Thr Leu Arg Met Arg Leu Ile Asp Ala Leu Glu Ser His 
145                 150                 155                 160 


Arg Asp Thr Trp Pro Pro Ala Cys Pro Pro Leu Glu Pro Ala Lys Leu 
                165                 170                 175     


Asn Asp Ile Asp Gly Phe Phe Thr Arg Asn Lys Ala Asp Tyr Leu Ala 
            180                 185                 190         


Leu Val Phe Glu Arg Glu Asp Ser Tyr Leu Gly Arg Glu Val Thr Leu 
        195                 200                 205             


Asp Leu Ser Gln Tyr His Ala Val Ala Val Arg Arg Val Leu Asn Thr 
    210                 215                 220                 


Glu Ser Asp Leu Val Asn Lys Phe Gly Val Thr Asp Phe Pro Ser Cys 
225                 230                 235                 240 


Tyr Leu Leu Leu Arg Asn Gly Ser Val Ser Arg Val Pro Val Leu Val 
                245                 250                 255     


Glu Ser Arg Ser Phe Tyr Thr Ser Tyr Leu Arg Gly Leu Pro Gly Leu 
            260                 265                 270         


Thr Arg Asp Ala Pro Pro Thr Thr Ala Thr Pro Val Thr Ala Asp Lys 
        275                 280                 285             


Ile Ala Pro Thr Val Trp Lys Phe Ala Asp Arg Ser Lys Ile Tyr Met 
    290                 295                 300                 


Ala Asp Leu Glu Ser Ala Leu His Tyr Ile Leu Arg Val Glu Val Gly 
305                 310                 315                 320 


Lys Phe Ser Val Leu Glu Gly Gln Arg Leu Val Ala Leu Lys Lys Phe 
                325                 330                 335     


Val Ala Val Leu Ala Lys Tyr Phe Pro Gly Gln Pro Leu Val Gln Asn 
            340                 345                 350         


Phe Leu His Ser Ile Asn Asp Trp Leu Gln Lys Gln Gln Lys Lys Arg 
        355                 360                 365             


Ile Pro Tyr Ser Phe Phe Lys Ala Ala Leu Asp Ser Arg Lys Glu Asp 
    370                 375                 380                 


Ala Val Leu Thr Glu Lys Val Asn Trp Val Gly Cys Gln Gly Ser Glu 
385                 390                 395                 400 


Pro His Phe Arg Gly Phe Pro Cys Ser Leu Trp Val Leu Phe His Phe 
                405                 410                 415     


Leu Thr Val Gln Ala Asn Arg Tyr Ser Glu Ala His Pro Gln Glu Pro 
            420                 425                 430         


Ala Asp Gly Gln Glu Val Leu Gln Ala Met Arg Ser Tyr Val Gln Phe 
        435                 440                 445             


Phe Phe Gly Cys Arg Asp Cys Ala Asp His Phe Glu Gln Met Ala Ala 
    450                 455                 460                 


Ala Ser Met His Gln Val Arg Ser Pro Ser Asn Ala Ile Leu Trp Leu 
465                 470                 475                 480 


Trp Thr Ser His Asn Arg Val Asn Ala Arg Leu Ser Gly Ala Leu Ser 
                485                 490                 495     


Glu Asp Pro His Phe Pro Lys Val Gln Trp Pro Pro Arg Glu Leu Cys 
            500                 505                 510         


Ser Ala Cys His Asn Glu Leu Asn Gly Gln Val Pro Leu Trp Asp Leu 
        515                 520                 525             


Gly Ala Thr Leu Asn Phe Leu Lys Ala His Phe Ser Pro Ala Asn Ile 
    530                 535                 540                 


Val Ile Asp Ser Ser Ala Ser Arg His Thr Gly Arg Arg Gly Ser Pro 
545                 550                 555                 560 


Glu Ala Thr Pro Glu Leu Val Met Asp Thr Leu Lys Leu Glu Ser Arg 
                565                 570                 575     


Asn Ser Val Leu Gly His Glu Gln Ala Ala Ser Ala Glu Ser Pro Gly 
            580                 585                 590         


Ala Thr Ala Leu Asp Val Pro Ala Glu Lys Pro Glu Ala Ser Gly Pro 
        595                 600                 605             


Gln Glu Leu Tyr Thr Gly Leu Arg Met Gly Gly Ala Ser Pro Gly Gln 
    610                 615                 620                 


Gly Pro Pro Glu Arg Met Glu Asp His Gln Arg Asp Met Gln Glu Asn 
625                 630                 635                 640 


Ala Pro Gly Gln Gln His Leu Ser Lys Arg Asp Thr Glu Ala Leu Phe 
                645                 650                 655     


Leu Pro Glu Val Asn His Leu Gln Gly Pro Leu Glu Leu Arg Arg Gly 
            660                 665                 670         


Gly Arg Ser Pro Lys Gln Leu Ala Pro Ile Leu Glu Glu Glu Pro Glu 
        675                 680                 685             


Ala Leu Ala Ile Gln Gly Gln Gly Gln Trp Leu Gln Val Leu Gly Gly 
    690                 695                 700                 


Gly Ile Ser His Leu Asp Ile Ser Leu Cys Val Gly Leu Tyr Ser Val 
705                 710                 715                 720 


Ser Phe Met Gly Leu Leu Ala Met Tyr Thr Tyr Phe Arg Ala Arg Leu 
                725                 730                 735     


Arg Thr Pro Lys Gly His Ala Ser Tyr Pro Thr Ala 
            740                 745             


<210>  33
<211>  568
<212>  PRT
<213>  Homo sapiens

<400>  33

Met Arg Arg Cys Gly Arg Leu Ser Gly Pro Pro Ser Leu Leu Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Ser Pro Leu Leu Phe Ser Gly Pro Gly Ala Tyr Ala 
            20                  25                  30          


Ala Arg Leu Ser Val Leu Tyr Ser Ser Ser Asp Pro Leu Thr Leu Leu 
        35                  40                  45              


Asp Ala Asp Ser Val Arg Pro Thr Val Leu Gly Ser Ser Ser Ala Trp 
    50                  55                  60                  


Ala Val Glu Phe Phe Ala Ser Trp Cys Gly His Cys Ile Ala Phe Ala 
65                  70                  75                  80  


Pro Thr Trp Lys Glu Leu Ala Asn Asp Val Lys Asp Trp Arg Pro Ala 
                85                  90                  95      


Leu Asn Leu Ala Val Leu Asp Cys Ala Glu Glu Thr Asn Ser Ala Val 
            100                 105                 110         


Cys Arg Glu Phe Asn Ile Ala Gly Phe Pro Thr Val Arg Phe Phe Gln 
        115                 120                 125             


Ala Phe Thr Lys Asn Gly Ser Gly Ala Thr Leu Pro Gly Ala Gly Ala 
    130                 135                 140                 


Asn Val Gln Thr Leu Arg Met Arg Leu Ile Asp Ala Leu Glu Ser His 
145                 150                 155                 160 


Arg Asp Thr Trp Pro Pro Ala Cys Pro Pro Leu Glu Pro Ala Lys Leu 
                165                 170                 175     


Asn Asp Ile Asp Gly Phe Phe Thr Arg Asn Lys Ala Asp Tyr Leu Ala 
            180                 185                 190         


Leu Val Phe Glu Arg Glu Asp Ser Tyr Leu Gly Arg Glu Val Thr Leu 
        195                 200                 205             


Asp Leu Ser Gln Tyr His Ala Val Ala Val Arg Arg Val Leu Asn Thr 
    210                 215                 220                 


Glu Ser Asp Leu Val Asn Lys Phe Gly Val Thr Asp Phe Pro Ser Cys 
225                 230                 235                 240 


Tyr Leu Leu Leu Arg Asn Gly Ser Val Ser Arg Val Pro Val Leu Val 
                245                 250                 255     


Glu Ser Arg Ser Phe Tyr Thr Ser Tyr Leu Arg Gly Leu Pro Gly Leu 
            260                 265                 270         


Thr Arg Asp Ala Pro Pro Thr Thr Ala Thr Pro Val Thr Ala Asp Lys 
        275                 280                 285             


Ile Ala Pro Thr Val Trp Lys Phe Ala Asp Arg Ser Lys Ile Tyr Met 
    290                 295                 300                 


Ala Asp Leu Glu Ser Ala Leu His Tyr Ile Leu Arg Val Glu Val Gly 
305                 310                 315                 320 


Lys Phe Ser Val Leu Glu Gly Gln Arg Leu Val Ala Leu Lys Lys Phe 
                325                 330                 335     


Val Ala Val Leu Ala Lys Tyr Phe Pro Gly Gln Pro Leu Val Gln Asn 
            340                 345                 350         


Phe Leu His Ser Ile Asn Asp Trp Leu Gln Lys Gln Gln Lys Lys Arg 
        355                 360                 365             


Ile Pro Tyr Ser Phe Phe Lys Ala Ala Leu Asp Ser Arg Lys Glu Asp 
    370                 375                 380                 


Ala Val Leu Thr Glu Lys Val Asn Trp Val Gly Cys Gln Gly Ser Glu 
385                 390                 395                 400 


Pro His Phe Arg Gly Phe Pro Cys Ser Leu Trp Val Leu Phe His Phe 
                405                 410                 415     


Leu Thr Val Gln Ala Asn Arg Tyr Ser Glu Ala His Pro Gln Glu Pro 
            420                 425                 430         


Ala Asp Gly Gln Glu Val Leu Gln Ala Met Arg Ser Tyr Val Gln Phe 
        435                 440                 445             


Phe Phe Gly Cys Arg Asp Cys Ala Asp His Phe Glu Gln Met Ala Ala 
    450                 455                 460                 


Ala Ser Met His Gln Val Arg Ser Pro Ser Asn Ala Ile Leu Trp Leu 
465                 470                 475                 480 


Trp Thr Ser His Asn Arg Val Asn Ala Arg Leu Ser Gly Ala Leu Ser 
                485                 490                 495     


Glu Asp Pro His Phe Pro Lys Val Gln Trp Pro Pro Arg Glu Leu Cys 
            500                 505                 510         


Ser Ala Cys His Asn Glu Leu Asn Gly Gln Val Pro Leu Trp Asp Leu 
        515                 520                 525             


Gly Ala Thr Leu Asn Phe Leu Lys Ala His Phe Ser Pro Ala Asn Ile 
    530                 535                 540                 


Val Ile Asp Ser Ser Ala Ser Arg His Thr Gly Arg Arg Gly Ser Pro 
545                 550                 555                 560 


Glu Ala Thr Pro Glu Leu Leu Leu 
                565             


<210>  34
<211>  3399
<212>  DNA
<213>  Homo sapiens

<400>  34
ctcctcctcc tcctccgggg cggaggctgt tggtgcgcgg caggctccgg atactgacta       60

gtcacaaact tgaaggaggt ggacattcaa gccgcctagg atgaggaggt gcggccgcct      120

ctcggggccg ccatcgctgc tgctactact gctgctgctc tcgcctctgc tcttctcggg      180

gcccggcgct tacgcggccc ggctctcagt gctctactcg tcctctgacc cgctgacgct      240

gctggatgct gattcggtgc gtcccactgt gctcggctcc agcagcgcct gggcggtgga      300

gttcttcgcc tcctggtgtg gccactgcat cgccttcgcc ccgacgtgga aggagcttgc      360

taacgacgtg aaagactgga ggccagcact caatcttgct gtcctggact gtgctgagga      420

gaccaacagt gctgtctgca gagagttcaa catcgctggc ttcccgactg tgaggttttt      480

tcaggccttt accaagaacg gttctggagc gacactgcca ggtgctggcg ctaatgtgca      540

gactctgcgt atgaggctca tcgatgctct ggagtcccac cgtgacacat ggcccccagc      600

ctgtccacct ctggaacctg ccaagctgaa tgatatcgac ggattcttta caagaaataa      660

agcagattac ctggccctgg tctttgaaag ggaagactcc tacctgggta gagaggtaac      720

tctggacctg tcccagtacc atgctgtggc agtgcgcagg gtcttgaata cagagagtga      780

cctggtgaac aagtttggcg tcactgactt cccatcttgt tacctgctgc ttcggaatgg      840

ctctgtctcc cgagtgcctg tgctggtgga gtccaggtct ttctatacat cctatcttcg      900

ggggctacct ggactgacca gggatgctcc cccaaccaca gccaccccag tcactgctga      960

taagatagca cccacagtgt ggaagtttgc agaccgctcc aagatctaca tggccgacct     1020

ggagtccgca ctccactaca tcttgcgtgt agaagtgggg aagttctcag tgctggaggg     1080

acagcgcctg gtggccctga aaaagtttgt ggcagtattg gccaagtact tccctgggca     1140

gcctttggtc cagaacttct tgcattccat aaacgactgg cttcagaagc agcagaagaa     1200

gaggatcccc tacagtttct tcaaagctgc tctggacagc aggaaggagg atgctgtcct     1260

tactgagaag gtgaactggg tcggctgcca gggcagtgag ccacacttcc gggggtttcc     1320

ctgctcactg tgggtcctct tccacttcct gacggtgcag gcaaaccgat atagtgaggc     1380

ccacccacag gaaccagctg atggccagga ggtcctccaa gccatgagga gctatgttca     1440

gttcttcttt ggctgtcgtg actgtgcgga ccattttgag cagatggctg cagcgtccat     1500

gcaccaagtg agaagtccca gtaatgcgat tctttggctc tggactagcc acaacagggt     1560

taacgctcgc ctctcaggtg ctctgagtga ggacccccac ttccccaagg tgcagtggcc     1620

tccccgtgag ctgtgttctg cctgccataa tgaactcaac ggacaggtgc ctttgtggga     1680

ccttggtgcc accctcaact ttctcaaggc tcacttctcc ccagcaaaca tcgtcataga     1740

ctcttctgca tctagacaca caggccggag agggagtcca gaagctaccc ccgagctggt     1800

aatggataca ttaaaactgg agagcagaaa ttcagtgttg ggccatgagc aggctgcttc     1860

tgcagagtcc cctggagcca ctgccctaga tgtaccagct gagaagcctg aagcaagtgg     1920

cccccaagaa ctatacacag gcctcagaat gggtggagct tcaccagggc agggccctcc     1980

tgagcgcatg gaagaccacc agagggatat gcaggagaat gcccccgggc agcaacactt     2040

gagcaagaga gacactgaag ccttatttct gcctgaggtg aaccacctcc aaggcccttt     2100

agagctcagg cgagggggcc gcagccccaa gcaactagcc cccatacttg aagaggaacc     2160

agaggcccta gctatacagg gccaaggcca gtggctgcag gttctaggag ggggcatttc     2220

ccacctggac attagcctct gtgtggggct ctactccgtg tccttcatgg gcttactggc     2280

catgtacacc tactttcggg ccaggctgag aaccccaaag ggccatgcta gttaccccac     2340

agcctgaact gcctcggcag aggacagaca aggagctgct gatgtctggg gctttgggtt     2400

tttttttttt ttttttggcc cactggcccc cttgcttcct ttctacccct tgttctgttg     2460

tctagcttag gagagtggca agtccaagaa agtgagttgt ttcagtgaac cctggagtct     2520

actgtgagag gattccctag acaaaacaga atcagggtgc cagtctcgcc tgaccagcat     2580

ggggtaggag cagcctgacg caggggctca ggaggcttct gggaggctca ggccctggct     2640

tcagcaccaa attctgtttt tcagctcttg tgaagtcctg ccccattcct gctgaagtct     2700

caatgtgtcc tgcttggtct tggccttaga ttgaggcaga caagtccaga gtttccaagg     2760

tttctcatcc agaggagtgt atgtgggccg ggtgggctgg agtggacctc ctcactgcat     2820

tctgagactg tctactcccc tccctcacga catgaagaaa aagcatccct ccggccttct     2880

ctggcctggc cagcttcagc acctcaggag tgggtggggc ttagcttcaa gaatgggtct     2940

gggagcctca gaaaatgatt ctggtcaccc aggttcaaac tggggtttct gctgcaagag     3000

tgtggtttgg caggctggga gggtgacagt tgctgcactg tagggtgtag tgcttgcttg     3060

gtggtagggg caagggggtg ggtgatgctg gggtctgtag tgccttagtc ctgggctagc     3120

tgggagaggg cagactcctc tctgagcggg ggtgcttgtc tcttactttg gtctctaaaa     3180

tcaatgctaa ctttggggtg tggaaggtgc tgggtttagg gcagtgggca gagccctctc     3240

tctcccgctt gggtccactg tgggcaggag ggggtggaga gaccagccca catttccttc     3300

ccctgctcct gtggcttggg agggatgtgg aataaaatta tttttgttaa gtcacgcaga     3360

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaa                            3399


<210>  35
<211>  2533
<212>  DNA
<213>  Homo sapiens

<400>  35
ctcctcctcc tcctccgggg cggaggctgt tggtgcgcgg caggctccgg atactgacta       60

gtcacaaact tgaaggaggt ggacattcaa gccgcctagg atgaggaggt gcggccgcct      120

ctcggggccg ccatcgctgc tgctactact gctgctgctc tcgcctctgc tcttctcggg      180

gcccggcgct tacgcggccc ggctctcagt gctctactcg tcctctgacc cgctgacgct      240

gctggatgct gattcggtgc gtcccactgt gctcggctcc agcagcgcct gggcggtgga      300

gttcttcgcc tcctggtgtg gccactgcat cgccttcgcc ccgacgtgga aggagcttgc      360

taacgacgtg aaagactgga ggccagcact caatcttgct gtcctggact gtgctgagga      420

gaccaacagt gctgtctgca gagagttcaa catcgctggc ttcccgactg tgaggttttt      480

tcaggccttt accaagaacg gttctggagc gacactgcca ggtgctggcg ctaatgtgca      540

gactctgcgt atgaggctca tcgatgctct ggagtcccac cgtgacacat ggcccccagc      600

ctgtccacct ctggaacctg ccaagctgaa tgatatcgac ggattcttta caagaaataa      660

agcagattac ctggccctgg tctttgaaag ggaagactcc tacctgggta gagaggtaac      720

tctggacctg tcccagtacc atgctgtggc agtgcgcagg gtcttgaata cagagagtga      780

cctggtgaac aagtttggcg tcactgactt cccatcttgt tacctgctgc ttcggaatgg      840

ctctgtctcc cgagtgcctg tgctggtgga gtccaggtct ttctatacat cctatcttcg      900

ggggctacct ggactgacca gggatgctcc cccaaccaca gccaccccag tcactgctga      960

taagatagca cccacagtgt ggaagtttgc agaccgctcc aagatctaca tggccgacct     1020

ggagtccgca ctccactaca tcttgcgtgt agaagtgggg aagttctcag tgctggaggg     1080

acagcgcctg gtggccctga aaaagtttgt ggcagtattg gccaagtact tccctgggca     1140

gcctttggtc cagaacttct tgcattccat aaacgactgg cttcagaagc agcagaagaa     1200

gaggatcccc tacagtttct tcaaagctgc tctggacagc aggaaggagg atgctgtcct     1260

tactgagaag gtgaactggg tcggctgcca gggcagtgag ccacacttcc gggggtttcc     1320

ctgctcactg tgggtcctct tccacttcct gacggtgcag gcaaaccgat atagtgaggc     1380

ccacccacag gaaccagctg atggccagga ggtcctccaa gccatgagga gctatgttca     1440

gttcttcttt ggctgtcgtg actgtgcgga ccattttgag cagatggctg cagcgtccat     1500

gcaccaagtg agaagtccca gtaatgcgat tctttggctc tggactagcc acaacagggt     1560

taacgctcgc ctctcaggtg ctctgagtga ggacccccac ttccccaagg tgcagtggcc     1620

tccccgtgag ctgtgttctg cctgccataa tgaactcaac ggacaggtgc ctttgtggga     1680

ccttggtgcc accctcaact ttctcaaggc tcacttctcc ccagcaaaca tcgtcataga     1740

ctcttctgca tctagacaca caggccggag agggagtcca gaagctaccc ccgagctgct     1800

cttgtgaagt cctgccccat tcctgctgaa gtctcaatgt gtcctgcttg gtcttggcct     1860

tagattgagg cagacaagtc cagagtttcc aaggtttctc atccagagga gtgtatgtgg     1920

gccgggtggg ctggagtgga cctcctcact gcattctgag actgtctact cccctccctc     1980

acgacatgaa gaaaaagcat ccctccggcc ttctctggcc tggccagctt cagcacctca     2040

ggagtgggtg gggcttagct tcaagaatgg gtctgggagc ctcagaaaat gattctggtc     2100

acccaggttc aaactggggt ttctgctgca agagtgtggt ttggcaggct gggagggtga     2160

cagttgctgc actgtagggt gtagtgcttg cttggtggta ggggcaaggg ggtgggtgat     2220

gctggggtct gtagtgcctt agtcctgggc tagctgggag agggcagact cctctctgag     2280

cgggggtgct tgtctcttac tttggtctct aaaatcaatg ctaactttgg ggtgtggaag     2340

gtgctgggtt tagggcagtg ggcagagccc tctctctccc gcttgggtcc actgtgggca     2400

ggagggggtg gagagaccag cccacatttc cttcccctgc tcctgtggct tgggagggat     2460

gtggaataaa attatttttg ttaagtcacg cagaaaaaaa aaaaaaaaaa aaaaaaaaaa     2520

aaaaaaaaaa aaa                                                        2533


<210>  36
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MAb492.1 variable light amino acid sequence

<400>  36

Asp Val Val Met Thr Gln Thr His Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asp Val Ser Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Ser Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


His Ser Ala Ser Tyr Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Val Gln Ala 
65                  70                  75                  80  


Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln His Tyr Ser Ile Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105         


<210>  37
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MAb492.1 variable heavy amino acid sequence

<400>  37

Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Gly Tyr 
            20                  25                  30          


Gly Val Asn Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Met Ile Trp Gly Asp Gly Arg Thr Asp Tyr Lys Ser Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Ser Ile Thr Lys Asp Asn Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Arg Tyr Phe Cys Ala 
                85                  90                  95      


Ser Asp Tyr Tyr Gly Ser Gly Ser Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ala 
        115             


<210>  38
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MAb492.1 light chain CDR1 amino acid sequence

<400>  38

Gln Asp Val Ser Thr Ala 
1               5       


<210>  39
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MAb492.1 light chain CDR2 amino acid sequence

<400>  39

Ser Ala Ser 
1           


<210>  40
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MAb492.1 light chain CDR3 amino acid sequence

<400>  40

Gln Gln His Tyr Ser Ile Pro Leu Thr 
1               5                   


<210>  41
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MAb492.1 heavy chain CDR1 amino acid sequence

<400>  41

Gly Phe Ser Leu Thr Gly Tyr Gly 
1               5               


<210>  42
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MAb492.1 heavy chain CDR2 amino acid sequence

<400>  42

Ile Trp Gly Asp Gly Arg Thr 
1               5           


<210>  43
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MAb492.1 heavy chain CDR3 amino acid sequence

<400>  43

Ala Ser Asp Tyr Tyr Gly Ser Gly Ser Phe Ala Tyr 
1               5                   10          


<210>  44
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MAb492.1gen variable light AA sequence

<400>  44

Asp Val Val Met Thr Gln Thr His Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asp Val Ser Gly Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Ser Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Ser Met Ala Ser Gln Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Val Gln Ala 
65                  70                  75                  80  


Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln His Tyr Ala Ile Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105         


<210>  45
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MAb492.1gen variable heavy AA sequence

<400>  45

Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Gly Tyr 
            20                  25                  30          


Ser Val Ile Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Met Ile Trp Gly Asp Gly Arg Thr Glu Tyr Lys Ser Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Ser Ile Thr Lys Asp Asn Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Arg Tyr Phe Cys Ala 
                85                  90                  95      


Ser Asp Ser Met Asp Pro Gly Ser Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ala 
        115             


<210>  46
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MAb492.1gen light chain CDR1 AA sequence

<400>  46

Gln Asp Val Ser Gly Ala 
1               5       


<210>  47
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MAb492.1gen light chain CDR2 AA sequence

<400>  47

Met Ala Ser 
1           


<210>  48
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MAb492.1gen light chain CDR3 AA sequence

<400>  48

Gln Gln His Tyr Ala Ile Pro Leu Thr 
1               5                   


<210>  49
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MAb492.1gen heavy chain CDR1 AA sequence

<400>  49

Gly Phe Ser Leu Thr Gly Tyr Ser 
1               5               


<210>  50
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MAb492.1gen heavy chain CDR2 AA sequence

<400>  50

Ile Trp Gly Asp Gly Arg Thr 
1               5           


<210>  51
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MAb492.1gen heavy chain CDR3 AA sequence

<400>  51

Ala Ser Asp Ser Met Asp Pro Gly Ser Phe Ala Tyr 
1               5                   10          


