                         SEQUENCE LISTING

<110>  F. Hoffmann-La Roche AG
 
<120>  ANTI-VARIANT FC-REGION ANTIBODIES AND METHODS OF USE

<130>  P33184-WO

<150>  EP15192195.4
<151>  2015-10-29

<160>  35    

<170>  PatentIn version 3.5

<210>  1
<211>  137
<212>  PRT
<213>  Mus musculus

<400>  1

Met Asp Phe Gly Leu Ile Phe Phe Ile Val Ala Leu Leu Lys Gly Val 
1               5                   10                  15      


Leu Cys Glu Val Arg Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro 
            20                  25                  30          


Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Asp Phe Ser 
        35                  40                  45              


Arg Tyr Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
    50                  55                  60                  


Trp Ile Gly Glu Ile Asn Pro Asp Ser Arg Pro Ile Asn Ser Ser Pro 
65                  70                  75                  80  


Ser Leu Lys Asp Lys Phe Ile Ile Ser Arg Asp Asn Val Lys Asn Thr 
                85                  90                  95      


Leu Tyr Leu Gln Met Asn Glu Leu Gly Ser Glu Asp Thr Ala Leu Tyr 
            100                 105                 110         


Tyr Cys Ala Arg Pro Leu Asp Tyr Gly Ala Trp Phe Ala Asn Trp Gly 
        115                 120                 125             


Gln Gly Thr Leu Val Ser Val Ser Ala 
    130                 135         


<210>  2
<211>  128
<212>  PRT
<213>  Mus musculus

<400>  2

Met Ala Trp Thr Ser Leu Phe Leu Ser Leu Leu Ala Leu Ser Ser Gly 
1               5                   10                  15      


Ala Ile Ser Gln Ala Val Val Thr Gln Glu Ser Ala Leu Thr Thr Ser 
            20                  25                  30          


Pro Gly Glu Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val 
        35                  40                  45              


Thr Thr Ser Asn Tyr Ala Asn Trp Val Gln Glu Lys Pro Asp His Val 
    50                  55                  60                  


Phe Ser Gly Leu Ile Gly Gly Thr Asn Lys Arg Ala Pro Gly Phe Pro 
65                  70                  75                  80  


Ala Arg Phe Ser Gly Ser Leu Ile Gly Asp Lys Ala Ala Leu Thr Ile 
                85                  90                  95      


Thr Gly Ala Gln Thr Glu Asp Glu Ala Ile Tyr Phe Cys Val Leu Trp 
            100                 105                 110         


Tyr Ser Asn His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
        115                 120                 125             


<210>  3
<211>  137
<212>  PRT
<213>  Mus musculus

<400>  3

Met Asp Phe Gly Leu Ile Phe Phe Ile Val Ala Leu Leu Lys Gly Val 
1               5                   10                  15      


Gln Cys Glu Val Lys Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro 
            20                  25                  30          


Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Ile Asp Phe Arg 
        35                  40                  45              


Arg Tyr Trp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
    50                  55                  60                  


Trp Ile Gly Glu Ile Asp Pro Asp Ser Ser Thr Ile Asn Tyr Thr Pro 
65                  70                  75                  80  


Ser Leu Lys Asp Lys Phe Ile Ile Ser Arg Asp Asn Ala Lys Asn Thr 
                85                  90                  95      


Met Tyr Leu Gln Met Arg Lys Val Arg Ser Glu Asp Thr Ala Leu Tyr 
            100                 105                 110         


Tyr Cys Ala Arg Pro Tyr Asp Tyr Gly Ala Trp Phe Ala Tyr Trp Gly 
        115                 120                 125             


Gln Gly Thr Leu Val Thr Val Ser Ala 
    130                 135         


<210>  4
<211>  128
<212>  PRT
<213>  Mus musculus

<400>  4

Met Ala Trp Ile Ser Leu Leu Phe Ser Leu Leu Ala Leu Ser Ser Gly 
1               5                   10                  15      


Ala Ile Ser Gln Ala Val Val Thr Gln Glu Ser Ala Leu Thr Thr Ser 
            20                  25                  30          


Pro Gly Glu Thr Val Thr Leu Thr Cys Arg Ser Thr Thr Gly Ala Val 
        35                  40                  45              


Thr Thr Ser Asn Tyr Ala Asn Trp Val Gln Glu Lys Pro Asp His Leu 
    50                  55                  60                  


Phe Thr Gly Leu Ile Gly Gly Thr Asn Lys Arg Ala Pro Gly Val Pro 
65                  70                  75                  80  


Ala Arg Phe Ser Gly Ser Leu Ile Gly Asp Lys Ala Ala Leu Thr Ile 
                85                  90                  95      


Thr Gly Ala Gln Thr Glu Asp Glu Ala Ile Tyr Phe Cys Ala Leu Trp 
            100                 105                 110         


Tyr Ser Asp His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
        115                 120                 125             


<210>  5
<211>  140
<212>  PRT
<213>  Mus musculus

<400>  5

Met Asn Phe Gly Leu Ser Leu Val Phe Leu Ala Leu Ile Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Lys 
            20                  25                  30          


Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Ser Tyr Gly Met Ser Trp Val Arg Gln Thr Pro Asp Lys Arg Leu 
    50                  55                  60                  


Glu Trp Val Ala Thr Ile Ser Ser Gly Gly Ser Tyr Ile Tyr Tyr Pro 
65                  70                  75                  80  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
                85                  90                  95      


Thr Leu Tyr Leu Gln Met Ser Ser Leu Lys Ser Glu Asp Thr Ala Met 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Leu Gly Met Ile Thr Thr Gly Tyr Ala Met Asp 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
    130                 135                 140 


<210>  6
<211>  112
<212>  PRT
<213>  Mus musculus

<400>  6

Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Thr Ile Val His Ser 
            20                  25                  30          


Thr Gly His Thr Tyr Leu Glu Trp Phe Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  7
<211>  137
<212>  PRT
<213>  Mus musculus

<400>  7

Met Asp Phe Gly Leu Ile Phe Phe Ile Val Ala Leu Leu Lys Gly Val 
1               5                   10                  15      


Gln Cys Glu Val Lys Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro 
            20                  25                  30          


Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Asp Phe Ser 
        35                  40                  45              


Arg Tyr Trp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
    50                  55                  60                  


Trp Ile Gly Glu Ile Thr Pro Asp Ser Ser Thr Ile Asn Tyr Thr Pro 
65                  70                  75                  80  


Ser Leu Lys Asp Lys Phe Ile Ile Ser Arg Asp Asn Ala Lys Asn Thr 
                85                  90                  95      


Leu Tyr Leu Gln Met Ile Lys Val Arg Ser Glu Asp Thr Ala Leu Tyr 
            100                 105                 110         


Tyr Cys Val Arg Pro Tyr Asp Tyr Gly Ala Trp Phe Ala Ser Trp Gly 
        115                 120                 125             


Gln Gly Thr Leu Val Thr Val Ser Ala 
    130                 135         


<210>  8
<211>  109
<212>  PRT
<213>  Mus musculus

<400>  8

Gln Ala Val Val Thr Gln Glu Ser Ala Leu Thr Thr Ser Pro Gly Glu 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Glu Lys Pro Asp His Leu Phe Thr Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Lys Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Ile Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Thr Glu Asp Glu Ala Ile Tyr Phe Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  9
<211>  5
<212>  PRT
<213>  Mus musculus

<400>  9

Arg Tyr Trp Met Ser 
1               5   


<210>  10
<211>  5
<212>  PRT
<213>  Mus musculus

<400>  10

Arg Tyr Trp Met Asn 
1               5   


<210>  11
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  HVR-H1 consensus sequence


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  X denotes a neutral hydrophilic amino acid residue

<400>  11

Arg Tyr Trp Met Xaa 
1               5   


<210>  12
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  12

Glu Ile Asn Pro Asp Ser Arg Pro Ile Asn Ser Ser Pro Ser Leu Lys 
1               5                   10                  15      


Asp 
    


<210>  13
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  13

Glu Ile Asp Pro Asp Ser Ser Thr Ile Asn Tyr Thr Pro Ser Leu Lys 
1               5                   10                  15      


Asp 
    


<210>  14
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  14

Glu Ile Thr Pro Asp Ser Ser Thr Ile Asn Tyr Thr Pro Ser Leu Lys 
1               5                   10                  15      


Asp 
    


<210>  15
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  HVR-H2 consensus sequence


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X = neutral hydrophilic or acidic amino acid residue

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  X = neutral hydrophilic or basic amino aicd residue

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  X = neutral hydrophilic or chain influencing amino aicd residue

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  X = neutral hydrophilic or aromatic amino aicd residue

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  X = neutral hydrophilic amino aicd residue

<400>  15

Glu Ile Xaa Pro Asp Ser Xaa Xaa Ile Asn Xaa Xaa Pro Ser Leu Lys 
1               5                   10                  15      


Asp 
    


<210>  16
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  16

Pro Leu Asp Tyr Gly Ala Trp Phe Ala Asn 
1               5                   10  


<210>  17
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  17

Pro Tyr Asp Tyr Gly Ala Trp Phe Ala Tyr 
1               5                   10  


<210>  18
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  18

Pro Tyr Asp Tyr Gly Ala Trp Phe Ala Ser 
1               5                   10  


<210>  19
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  HVR-H3 consensus sequence


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  X=hydrophobic or aromatic amino acid residue

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  X=neutral hydrophilic or aromatic amino acid residue

<400>  19

Pro Xaa Asp Tyr Gly Ala Trp Phe Ala Xaa 
1               5                   10  


<210>  20
<211>  5
<212>  PRT
<213>  Mus musculus

<400>  20

Ser Tyr Gly Met Ser 
1               5   


<210>  21
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  21

Thr Ile Ser Ser Gly Gly Ser Tyr Ile Tyr Tyr Pro Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  22
<211>  12
<212>  PRT
<213>  Mus musculus

<400>  22

Leu Gly Met Ile Thr Thr Gly Tyr Ala Met Asp Tyr 
1               5                   10          


<210>  23
<211>  14
<212>  PRT
<213>  Mus musculus

<400>  23

Arg Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210>  24
<211>  14
<212>  PRT
<213>  Mus musculus

<400>  24

Arg Ser Thr Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210>  25
<211>  14
<212>  PRT
<213>  Artificial sequence

<220>
<223>  HVR-L1 consensus sequence


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X=neutral hydrophilic amino acid residue

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  X=neutral hydrophilic or acidic amino acid residue

<400>  25

Arg Ser Xaa Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Xaa 
1               5                   10                  


<210>  26
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  26

Gly Thr Asn Lys Arg Ala Pro 
1               5           


<210>  27
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  HVR-L2 consesus sequence


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  X=acidic or basic amino acid residue

<400>  27

Gly Thr Asn Xaa Arg Ala Pro 
1               5           


<210>  28
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  28

Val Leu Trp Tyr Ser Asn His Trp Val 
1               5                   


<210>  29
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  29

Ala Leu Trp Tyr Ser Asp His Trp Val 
1               5                   


<210>  30
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  30

Ala Leu Trp Tyr Ser Asn His Trp Val 
1               5                   


<210>  31
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  HVR-L3 consensus sequence


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa can be any naturally occurring amino acid

<400>  31

Xaa Leu Trp Tyr Ser Xaa His Trp Val 
1               5                   


<210>  32
<211>  16
<212>  PRT
<213>  Mus musculus

<400>  32

Arg Ser Ser Gln Thr Ile Val His Ser Thr Gly His Thr Tyr Leu Glu 
1               5                   10                  15      


<210>  33
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  HVR-L1 consensus sequence


<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  X=neutral or chain orientation influencing amino acid residue

<400>  33

Arg Ser Ser Gln Thr Ile Val His Xaa Thr Gly His Thr Tyr Leu Glu 
1               5                   10                  15      


<210>  34
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  34

Lys Val Ser Asn Arg Phe Ser 
1               5           


<210>  35
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  35

Phe Gln Gly Ser His Val Pro Tyr Thr 
1               5                   


