<110> 
<120> PCSK9ƼƱTϸ鵼֢ԼҩеӦ
<160> 1
<210> 1
<211> 692 
<212> PRT
<213>  (Homo sapiens)
<400> 1

Met Gly Thr Val Ser Ser Arg Arg Ser Trp Trp Pro Leu Pro Leu 
1                5                   10                  15
Leu Leu Leu Leu Leu Leu Leu Leu Gly Pro Ala Gly Ala Arg Ala
                 20                  25                  30
Gln Glu Asp Glu Asp Gly Asp Tyr Glu Glu Leu Val Leu Ala Leu 
                 35                  40                  45
Arg Ser Glu Glu Asp Gly Leu Ala Glu Ala Pro Glu His Gly Thr   
                 50                  55                  60
Thr Ala Thr Phe His Arg Cys Ala Lys Asp Pro Trp Arg Leu Pro
                 65                  70                  75
Gly Thr Tyr Val Val Val Leu Lys Glu Glu Thr His Leu Ser Gln
                 80                  85                  90
Ser Glu Arg Thr Ala Arg Arg Leu Gln Ala Gln Ala Ala Arg Arg
                 95                 100                 105
Gly Tyr Leu Thr Lys Ile Leu His Val Phe His Gly Leu Leu Pro
                110                 115                 120
Gly Phe Leu Val Lys Met Ser Gly Asp Leu Leu Glu Leu Ala Leu
                125                 130                 135
Lys Leu Pro His Val Asp Tyr Ile Glu Glu Asp Ser Ser Val Phe
                140                 145                 150
Ala Gln Ser Ile Pro Trp Asn Leu Glu Arg Ile Thr Pro Pro Arg
                155                 160                 165
Tyr Arg Ala Asp Glu Tyr Gln Pro Pro Asp Gly Gly Ser Leu Val
                170                 175                 180
Glu Val Tyr Leu Leu Asp Thr Ser Ile Gln Ser Asp His Arg Glu
                185                 190                 195
Ile Glu Gly Arg Val Met Val Thr Asp Phe Glu Asn Val Pro Glu
                200                 205                 210
Glu Asp Gly Thr Arg Phe His Arg Gln Ala Ser Lys Cys Asp Ser
                215                 220                 225
His Gly Thr His Leu Ala Gly Val Val Ser Gly Arg Asp Ala Gly
                230                 235                 240
Val Ala Lys Gly Ala Ser Met Arg Ser Leu Arg Val Leu Asn Cys
                245                 250                 255
Gln Gly Lys Gly Thr Val Ser Gly Thr Leu Ile Gly Leu Glu Phe
                260                 265                 270
Ile Arg Lys Ser Gln Leu Val Gln Pro Val Gly Pro Leu Val Val
                275                 280                 285
Leu Leu Pro Leu Ala Gly Gly Tyr Ser Arg Val Leu Asn Ala Ala
                290                 295                 300
Cys Gln Arg Leu Ala Arg Ala Gly Val Val Leu Val Thr Ala Ala
                305                 310                 315
Gly Asn Phe Arg Asp Asp Ala Cys Leu Tyr Ser Pro Ala Ser Ala
                320                 325                 330
Pro Glu Val Ile Thr Val Gly Ala Thr Asn Ala Gln Asp Gln Pro
                335                 340                 345
Val Thr Leu Gly Thr Leu Gly Thr Asn Phe Gly Arg Cys Val Asp
                350                 355                 360
Leu Phe Ala Pro Gly Glu Asp Ile Ile Gly Ala Ser Ser Asp Cys
                365                 370                 375
Ser Thr Cys Phe Val Ser Gln Ser Gly Thr Ser Gln Ala Ala Ala
                380                 385                 390
His Val Ala Gly Ile Ala Ala Met Met Leu Ser Ala Glu Pro Glu
                395                 400                 405
Leu Thr Leu Ala Glu Leu Arg Gln Arg Leu Ile His Phe Ser Ala
                410                 415                 420
Lys Asp Val Ile Asn Glu Ala Trp Phe Pro Glu Asp Gln Arg Val
                425                 430                 435
Leu Thr Pro Asn Leu Val Ala Ala Leu Pro Pro Ser Thr His Gly
                440                 445                 450
Ala Gly Trp Gln Leu Phe Cys Arg Thr Val Trp Ser Ala His Ser
                455                 460                 465
Gly Pro Thr Arg Met Ala Thr Ala Val Ala Arg Cys Ala Pro Asp
                470                 475                 480
Glu Glu Leu Leu Ser Cys Ser Ser Phe Ser Arg Ser Gly Lys Arg
                485                 490                 495
Arg Gly Glu Arg Met Glu Ala Gln Gly Gly Lys Leu Val Cys Arg
                500                 505                 510
Ala His Asn Ala Phe Gly Gly Glu Gly Val Tyr Ala Ile Ala Arg
                515                 520                 525
Cys Cys Leu Leu Pro Gln Ala Asn Cys Ser Val His Thr Ala Pro
                530                 535                 540
Pro Ala Glu Ala Ser Met Gly Thr Arg Val His Cys His Gln Gln
                545                 550                 555
Gly His Val Leu Thr Gly Cys Ser Ser His Trp Glu Val Glu Asp
                560                 565                 570
Leu Gly Thr His Lys Pro Pro Val Leu Arg Pro Arg Gly Gln Pro
                575                 580                 585
Asn Gln Cys Val Gly His Arg Glu Ala Ser Ile His Ala Ser Cys
                590                 595                 600
Cys His Ala Pro Gly Leu Glu Cys Lys Val Lys Glu His Gly Ile
                605                 610                 615
Pro Ala Pro Gln Glu Gln Val Thr Val Ala Cys Glu Glu Gly Trp
                620                 625                 630
Thr Leu Thr Gly Cys Ser Ala Leu Pro Gly Thr Ser His Val Leu
                635                 640                 645
Gly Ala Tyr Ala Val Asp Asn Thr Cys Val Val Arg Ser Arg Asp
                650                 655                 660
Val Ser Thr Thr Gly Ser Thr Ser Glu Gly Ala Val Thr Ala Val
                665                 670                 675
Ala Ile Cys Cys Arg Ser Arg His Leu Ala Gln Ala Ser Gln Glu 
                680                 685                 690
Leu Gln
