                         SEQUENCE LISTING

<110>  University of Maryland, Baltimore
 
<120>  Methods for Generating Engineered Human Primary Blood Dendritic 
       Cell Lines

<130>  UMB-039PCT1

<150>  62/243,177
<151>  2015-10-19

<160>  54    

<170>  PatentIn version 3.5

<210>  1
<211>  353
<212>  PRT
<213>  HTLV-1

<400>  1

Met Ala His Phe Pro Gly Phe Gly Gln Ser Leu Leu Phe Gly Tyr Pro 
1               5                   10                  15      


Val Tyr Val Phe Gly Asp Cys Val Gln Gly Asp Trp Cys Pro Ile Ser 
            20                  25                  30          


Gly Gly Leu Cys Ser Ala Arg Leu His Arg His Ala Leu Leu Ala Thr 
        35                  40                  45              


Cys Pro Glu His Gln Ile Thr Trp Asp Pro Ile Asp Gly Arg Val Ile 
    50                  55                  60                  


Gly Ser Ala Leu Gln Phe Leu Ile Pro Arg Leu Pro Ser Phe Pro Thr 
65                  70                  75                  80  


Gln Arg Thr Ser Lys Thr Leu Lys Val Leu Thr Pro Pro Ile Thr His 
                85                  90                  95      


Thr Thr Pro Asn Ile Pro Pro Ser Phe Leu Gln Ala Met Arg Lys Tyr 
            100                 105                 110         


Ser Pro Phe Arg Asn Gly Tyr Met Glu Pro Thr Leu Gly Gln His Leu 
        115                 120                 125             


Pro Thr Leu Ser Phe Pro Asp Pro Gly Leu Arg Pro Gln Asn Leu Tyr 
    130                 135                 140                 


Thr Leu Trp Gly Gly Ser Val Val Cys Met Tyr Leu Tyr Gln Leu Ser 
145                 150                 155                 160 


Pro Pro Ile Thr Trp Pro Leu Leu Pro His Val Ile Phe Cys His Pro 
                165                 170                 175     


Gly Gln Leu Gly Ala Phe Leu Thr Asn Val Pro Tyr Lys Arg Ile Glu 
            180                 185                 190         


Glu Leu Leu Tyr Lys Ile Ser Leu Thr Thr Gly Ala Leu Ile Ile Leu 
        195                 200                 205             


Pro Glu Asp Cys Leu Pro Thr Thr Leu Phe Gln Pro Ala Arg Ala Pro 
    210                 215                 220                 


Val Thr Leu Thr Ala Trp Gln Asn Gly Leu Leu Pro Phe His Ser Thr 
225                 230                 235                 240 


Leu Thr Thr Pro Gly Leu Ile Trp Thr Phe Thr Asp Gly Thr Pro Met 
                245                 250                 255     


Ile Ser Gly Pro Cys Pro Lys Asp Gly Gln Pro Ser Leu Val Leu Gln 
            260                 265                 270         


Ser Ser Ser Phe Ile Phe His Lys Phe Gln Thr Lys Ala Tyr His Pro 
        275                 280                 285             


Ser Phe Leu Leu Ser His Gly Leu Ile Gln Tyr Ser Ser Phe His Ser 
    290                 295                 300                 


Leu His Leu Leu Phe Glu Glu Tyr Thr Asn Ile Pro Ile Ser Leu Leu 
305                 310                 315                 320 


Phe Asn Glu Lys Glu Ala Asp Asp Asn Asp His Glu Pro Gln Ile Ser 
                325                 330                 335     


Pro Gly Gly Leu Glu Pro Pro Ser Glu Lys His Phe Arg Glu Thr Glu 
            340                 345                 350         


Val 
    


<210>  2
<211>  1062
<212>  DNA
<213>  HTLV-1

<400>  2
atggcccatt tcccagggtt tggacagagt cttcttttcg gatacccagt ctacgtgttt       60

ggagactgtg tacaaggcga ctggtgcccc atctctgggg gactatgttc ggcccgccta      120

catcgtcacg ccctactggc cacctgtcca gagcatcaga tcacctggga ccccatcgac      180

ggacgcgtta tcggctcagc tctacagttc cttatccctc gactcccctc cttccccacc      240

cagagaacct ctaagaccct caaggtcctt accccgccaa tcactcatac aacccccaac      300

attccaccct ccttcctcca ggccatgcgc aaatactccc ccttccgaaa tggatacatg      360

gaacccaccc ttgggcagca cctcccaacc ctgtcttttc cagaccccgg actccggccc      420

caaaacctgt acaccctctg gggaggctcc gttgtctgca tgtacctcta ccagctttcc      480

ccccccatca cctggcccct cctgccccac gtgatttttt gccaccccgg ccagctcggg      540

gccttcctca ccaatgttcc ctacaagcga atagaagaac tcctctataa aatttccctc      600

accacagggg ccctaataat tctacccgaa gactgtttgc ccaccaccct tttccagcct      660

gctagggcac ccgtcacgct aacagcctgg caaaacggcc tccttccgtt ccactcaacc      720

ctcaccactc caggccttat ttggacattt accgatggca cgcctatgat ttccgggccc      780

tgccctaaag atggccagcc atctttagta ctacagtcct cctcctttat atttcacaaa      840

tttcaaacca aggcctacca cccctcattt ctactctcac acggcctcat acagtactct      900

tcctttcata gtttacatct cctgtttgaa gaatacacca acatccccat ttctctactt      960

tttaacgaaa aagaggcaga tgacaatgac catgagcccc aaatatcccc cgggggctta     1020

gagcctccca gtgaaaaaca tttccgagaa acagaagtct ga                        1062


<210>  3
<211>  331
<212>  PRT
<213>  HTLV-2

<400>  3

Met Ala His Phe Pro Gly Phe Gly Gln Ser Leu Leu Tyr Gly Tyr Pro 
1               5                   10                  15      


Val Tyr Val Phe Gly Asp Cys Val Gln Ala Asp Trp Cys Pro Val Ser 
            20                  25                  30          


Gly Gly Leu Cys Ser Thr Arg Leu His Arg His Ala Leu Leu Ala Thr 
        35                  40                  45              


Cys Pro Glu His Gln Leu Thr Trp Asp Pro Ile Asp Gly Arg Val Val 
    50                  55                  60                  


Ser Ser Pro Leu Gln Tyr Leu Ile Pro Arg Leu Pro Ser Phe Pro Thr 
65                  70                  75                  80  


Gln Arg Thr Ser Arg Thr Leu Lys Val Leu Thr Pro Pro Thr Thr Pro 
                85                  90                  95      


Val Ser Pro Lys Val Pro Pro Ala Phe Phe Gln Ser Met Arg Lys His 
            100                 105                 110         


Thr Pro Tyr Arg Asn Gly Cys Leu Glu Pro Thr Leu Gly Asp Gln Leu 
        115                 120                 125             


Pro Ser Leu Ala Phe Pro Glu Pro Gly Leu Arg Pro Gln Asn Ile Tyr 
    130                 135                 140                 


Thr Thr Trp Gly Lys Thr Val Val Cys Leu Tyr Leu Tyr Gln Leu Ser 
145                 150                 155                 160 


Pro Pro Met Thr Trp Pro Leu Ile Pro His Val Ile Phe Cys His Pro 
                165                 170                 175     


Arg Gln Leu Gly Ala Phe Leu Thr Lys Val Pro Leu Lys Arg Leu Glu 
            180                 185                 190         


Glu Leu Leu Tyr Lys Met Phe Leu His Thr Gly Thr Val Ile Val Leu 
        195                 200                 205             


Pro Val Asp Asp Leu Pro Thr Thr Met Phe Gln Pro Val Arg Ala Pro 
    210                 215                 220                 


Cys Ile Gln Thr Ala Trp Cys Thr Gly Leu Leu Pro Tyr His Ser Ile 
225                 230                 235                 240 


Leu Thr Thr Pro Gly Leu Ile Trp Thr Phe Asn Asp Gly Ser Pro Met 
                245                 250                 255     


Ile Ser Gly Pro Cys Pro Lys Ala Gly Gln Pro Ser Leu Val Val Gln 
            260                 265                 270         


Ser Ser Leu Leu Ile Phe Glu Lys Phe Gln Thr Lys Ala Phe His Pro 
        275                 280                 285             


Ser Tyr Leu Leu Ser His Gln Leu Ile Gln Tyr Ser Ser Phe His Asn 
    290                 295                 300                 


Leu His Leu Leu Phe Asp Glu Tyr Thr Asn Ile Pro Val Ser Ile Leu 
305                 310                 315                 320 


Phe Asn Lys Glu Glu Ala Asp Asp Asn Gly Asp 
                325                 330     


<210>  4
<211>  996
<212>  DNA
<213>  HTLV-2

<400>  4
atggcccatt tcccaggatt tggacaaagc ctcctatatg gataccccgt ctacgtgttt       60

ggcgattgtg tacaggccga ttggtgtccc gtctcaggtg gtctatgttc cacccgccta      120

catcgacatg ccctcctggc cacctgtcca gagcaccaac tcacctggga ccccatcgat      180

ggacgcgttg tcagctctcc tctccaatac cttatccctc gcctcccctc cttccccacc      240

cagagaacct caaggaccct caaggtcctt acccctccca ccactcctgt ctcccccaag      300

gttccacctg ccttctttca atcaatgcga aagcacaccc cctaccgaaa tggatgcctg      360

gaaccaaccc tcggggatca gctcccctcc ctcgccttcc ccgaacctgg cctccgtccc      420

caaaacatct acaccacctg gggaaaaacc gtagtatgcc tatacctata ccagctttcc      480

ccacccatga catggccact tataccccat gtcatattct gccaccccag acaattagga      540

gccttcctca ccaaggtgcc tctaaaacga ttagaagaac ttctatacaa aatgttccta      600

cacacaggga cagtcatagt cctcccagtg gacgacctac ccaccacaat gttccaaccc      660

gtgagggctc cctgtatcca gactgcctgg tgtacaggac ttctccccta tcactccatc      720

ttaacaaccc caggtctaat atggaccttc aatgacggct caccaatgat ttccggccct      780

tgccccaaag cagggcagcc atctttagta gttcagtcct ccctattaat cttcgaaaaa      840

ttccaaacca aagccttcca tccctcctat ctactctctc atcagcttat acaatactcc      900

tccttccata accttcacct tctattcgat gaatacacca acatccctgt ctctatttta      960

tttaataaag aagaggcgga tgacaatggc gactga                                996


<210>  5
<211>  350
<212>  PRT
<213>  HTLV-3

<400>  5

Met Ala His Phe Pro Gly Phe Gly Gln Ser Leu Leu Tyr Gly Tyr Pro 
1               5                   10                  15      


Val Tyr Val Phe Gly Asp Cys Val Gln Ala Asp Trp Cys Pro Ile Ser 
            20                  25                  30          


Gly Gly Leu Cys Ser Ala Arg Leu His Arg His Ala Leu Leu Ala Thr 
        35                  40                  45              


Cys Pro Glu His Gln Ile Thr Trp Asp Pro Ile Asp Gly Arg Val Val 
    50                  55                  60                  


Ser Ser Ala Leu Gln Tyr Leu Ile Pro Arg Leu Pro Ser Phe Pro Thr 
65                  70                  75                  80  


Gln Arg Thr Thr Arg Thr Leu Lys Val Leu Thr Pro Pro Thr Thr Ala 
                85                  90                  95      


Ala Thr Pro Lys Ile Pro Pro Ser Phe Phe His Ala Val Lys Lys His 
            100                 105                 110         


Thr Pro Phe Arg Asn Asn Cys Leu Glu Leu Thr Leu Gly Glu Gln Leu 
        115                 120                 125             


Pro Ala Met Ser Phe Pro Asp Pro Gly Leu Arg Pro Gln Asn Ile Tyr 
    130                 135                 140                 


Thr Met Trp Gly Ser Ser Val Val Cys Leu Tyr Leu Tyr Gln Leu Ser 
145                 150                 155                 160 


Pro Pro Met Thr Trp Pro Leu Ile Pro His Val Ile Phe Cys His Pro 
                165                 170                 175     


Glu Gln Leu Gly Ala Phe Leu Thr Arg Val Pro Thr Lys Arg Leu Glu 
            180                 185                 190         


Glu Leu Leu Tyr Lys Ile Phe Leu Ser Thr Gly Ala Ile Ile Ile Leu 
        195                 200                 205             


Pro Glu Asn Cys Phe Pro Thr Thr Leu Phe Gln Pro Thr Arg Ala Pro 
    210                 215                 220                 


Ala Val Gln Ala Pro Trp His Thr Gly Leu Leu Pro Cys Gln Lys Glu 
225                 230                 235                 240 


Ile Ala Thr Pro Gly Leu Ile Trp Thr Phe Thr Asp Gly Ser Pro Met 
                245                 250                 255     


Ile Ser Gly Pro Cys Pro Lys Glu Gly Gln Pro Ser Leu Val Val Gln 
            260                 265                 270         


Ser Ser Thr Phe Ile Phe Gln Gln Phe Gln Thr Lys Ala Ser His Pro 
        275                 280                 285             


Ala Phe Leu Leu Ser His Lys Leu Ile His Tyr Ser Ser Phe His Ser 
    290                 295                 300                 


Leu His Leu Leu Phe Glu Glu Tyr Thr Thr Ile Pro Phe Ser Leu Leu 
305                 310                 315                 320 


Phe Asn Glu Lys Gly Ala Asn Val Asp Asp Asp Glu Pro Arg Asp Gly 
                325                 330                 335     


Ser Gln Pro Pro Ala Arg Gly Gln Ile Ala Glu Ser Pro Val 
            340                 345                 350 


<210>  6
<211>  1053
<212>  DNA
<213>  HTLV-3

<400>  6
atggcccatt tcccaggttt cggacagagc cttctctacg ggtaccctgt ctacgttttc       60

ggcgactgtg tacaggccga ttggtgcccc atttctgggg ggctttgttc cgctcggcta      120

caccgccatg ccctactggc cacgtgcccc gaacatcaga ttacctggga ccccatcgat      180

ggacgcgttg tcagctcagc tctacaatac cttatccctc gactcccctc cttccccacc      240

cagagaacta cccgcaccct caaggttctc acccccccaa ccactgctgc gacccccaag      300

attcctccat ccttcttcca cgccgttaaa aaacacaccc ccttccgaaa caattgcctt      360

gaactcaccc tgggagagca gttgccagcc atgtccttcc ccgaccctgg gctccgaccc      420

caaaacatct acaccatgtg gggaagctcc gttgtgtgcc tttacctcta tcagctctcc      480

ccccccatga cctggcctct aatcccgcat gttatattct gccatcctga gcagcttgga      540

gccttcctca cccgagtccc taccaaacga ttagaagaac tcctgtataa gatattttta      600

agcacagggg cgataatcat cctgcctgaa aactgttttc caaccaccct gttccaaccc      660

acccgcgcgc ccgcggtgca ggccccctgg cacacaggcc tgctcccgtg tcaaaaggaa      720

attgctaccc ccgggctcat ttggactttc actgatggca gccccatgat ttccggccct      780

tgccccaaag aaggacagcc atctttagta gtacaatcat ctacatttat ctttcaacaa      840

ttccaaacca aggccagtca ccccgctttc ctcttgtccc acaaactaat ccactactcc      900

tcttttcatt ccctccacct cctctttgag gaatatacaa ctatcccctt ttctctactt      960

tttaatgaaa aaggggcaaa tgtcgatgat gatgagcccc gagacgggtc acaaccacca     1020

gctagaggac aaatagctga gtcacccgtc tga                                  1053


<210>  7
<211>  345
<212>  PRT
<213>  HTLV-4

<400>  7

Met Ala His Phe Pro Gly Phe Gly Gln Ser Leu Leu Tyr Gly Tyr Pro 
1               5                   10                  15      


Val Tyr Val Phe Gly Asp Cys Val Gln Ala Asp Trp Cys Pro Ile Ser 
            20                  25                  30          


Gly Gly Leu Cys Ser Pro Arg Leu His Arg His Ala Leu Leu Ala Thr 
        35                  40                  45              


Cys Pro Glu His Gln Ile Thr Trp Asp Pro Ile Asp Gly Arg Val Val 
    50                  55                  60                  


Gly Ser Pro Leu Gln Tyr Leu Ile Pro Arg Leu Pro Ser Phe Pro Thr 
65                  70                  75                  80  


Gln Arg Thr Ser Lys Thr Leu Lys Val Leu Thr Pro Pro Thr Thr Pro 
                85                  90                  95      


Val Thr Pro Lys Val Pro Pro Ser Phe Phe Gln Ser Val Arg Arg His 
            100                 105                 110         


Ser Pro Tyr Arg Asn Gly Cys Leu Glu Thr Thr Leu Gly Glu Gln Leu 
        115                 120                 125             


Pro Ser Leu Ala Phe Pro Glu Pro Gly Leu Arg Pro Gln Asn Val Tyr 
    130                 135                 140                 


Thr Ile Trp Gly Lys Thr Ile Val Cys Leu Tyr Ile Tyr Gln Leu Ser 
145                 150                 155                 160 


Pro Pro Met Thr Trp Pro Leu Ile Pro His Val Ile Phe Cys Asn Pro 
                165                 170                 175     


Arg Gln Leu Gly Ala Phe Leu Ser Asn Val Pro Pro Lys Arg Leu Glu 
            180                 185                 190         


Glu Leu Leu Tyr Lys Leu Tyr Leu His Thr Gly Ala Ile Ile Ile Leu 
        195                 200                 205             


Pro Glu Asp Ala Leu Pro Thr Thr Leu Phe Gln Pro Val Arg Ala Pro 
    210                 215                 220                 


Cys Val Gln Thr Thr Trp Asn Thr Gly Leu Leu Pro Tyr Gln Pro Asn 
225                 230                 235                 240 


Leu Thr Thr Pro Gly Leu Ile Trp Thr Phe Asn Asp Gly Ser Pro Met 
                245                 250                 255     


Ile Ser Gly Pro Cys Pro Lys Ala Gly Gln Pro Ser Leu Val Val Gln 
            260                 265                 270         


Ser Ser Leu Leu Ile Phe Glu Arg Phe Gln Thr Lys Ala Tyr His Pro 
        275                 280                 285             


Ser Tyr Leu Leu Ser His Gln Leu Ile Gln Tyr Ser Ser Phe His His 
    290                 295                 300                 


Leu Tyr Leu Leu Phe Asp Glu Tyr Thr Thr Ile Pro Phe Ser Leu Leu 
305                 310                 315                 320 


Phe Lys Glu Lys Glu Gly Asp Asp Arg Asp Asn Asp Pro Leu Pro Gly 
                325                 330                 335     


Ala Thr Ala Ser Pro Gln Gly Gln Asn 
            340                 345 


<210>  8
<211>  1038
<212>  DNA
<213>  HTLV-4

<400>  8
atggcccact tcccaggatt cgggcagagc ctcctctatg gataccccgt ctatgtgttt       60

ggcgattgtg ttcaagccga ttggtgcccc atctccggtg gattatgctc cccccgccta      120

catcgccacg ccctcctggc cacctgcccc gagcaccaga tcacctggga ccccatcgat      180

ggacgagttg tcggctcgcc tctccaatac cttatccctc gcctcccctc cttccccacc      240

caacgaacct ccaagaccct caaagtcctt accccaccaa ccactcctgt cacccccaag      300

gttccaccct ccttctttca gtccgtgcgg aggcacagcc cctaccgcaa cggatgtctt      360

gaaacaaccc ttggagagca gctcccctcc cttgcatttc ctgagccagg cctcaggccc      420

caaaacgtct acaccatctg gggaaagacc atagtgtgtc tatacatcta ccagctgtcc      480

cctcccatga cctggcccct cattccccat gtcatatttt gcaaccccag gcagcttggc      540

gcttttctaa gcaatgtgcc ccccaagcga ttagaagaac tcctctacaa actttatcta      600

cacaccggcg ccataatcat cctgccggaa gacgccctgc ctaccaccct atttcagcct      660

gttcgagcac cctgtgtcca aactacctgg aacacaggac ttctcccata ccagccaaac      720

ctgactaccc ctggcctgat atggaccttt aatgatgggt ctcctatgat ttcaggacct      780

tgccctaagg cagggcagcc atccttggta gtacagtcct cactactaat cttcgagaga      840

tttcaaacca aagcctatca tccctcttac ctcctctccc accaattgat acagtattcc      900

tccttccatc acctctactt actctttgat gaatatacta ctatcccctt ctctctacta      960

tttaaggaaa aagagggaga tgacagggac aacgaccctc tcccaggggc gacagcaagc     1020

ccccaaggac aaaactag                                                   1038


<210>  9
<211>  1069
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Pro Arg Ala Pro Arg Cys Arg Ala Val Arg Ser Leu Leu Arg Ser 
1               5                   10                  15      


His Tyr Arg Glu Val Leu Pro Leu Ala Thr Phe Val Arg Arg Leu Gly 
            20                  25                  30          


Pro Gln Gly Trp Arg Leu Val Gln Arg Gly Asp Pro Ala Ala Phe Arg 
        35                  40                  45              


Ala Leu Val Ala Gln Cys Leu Val Cys Val Pro Trp Asp Ala Arg Pro 
    50                  55                  60                  


Pro Pro Ala Ala Pro Ser Phe Arg Gln Val Ser Cys Leu Lys Glu Leu 
65                  70                  75                  80  


Val Ala Arg Val Leu Gln Arg Leu Cys Glu Arg Gly Ala Lys Asn Val 
                85                  90                  95      


Leu Ala Phe Gly Phe Ala Leu Leu Asp Gly Ala Arg Gly Gly Pro Pro 
            100                 105                 110         


Glu Ala Phe Thr Thr Ser Val Arg Ser Tyr Leu Pro Asn Thr Val Thr 
        115                 120                 125             


Asp Ala Leu Arg Gly Ser Gly Ala Trp Gly Leu Leu Leu Arg Arg Val 
    130                 135                 140                 


Gly Asp Asp Val Leu Val His Leu Leu Ala Arg Cys Ala Leu Phe Val 
145                 150                 155                 160 


Leu Val Ala Pro Ser Cys Ala Tyr Gln Val Cys Gly Pro Pro Leu Tyr 
                165                 170                 175     


Gln Leu Gly Ala Ala Thr Gln Ala Arg Pro Pro Pro His Ala Ser Gly 
            180                 185                 190         


Pro Arg Arg Arg Leu Gly Cys Glu Arg Ala Trp Asn His Ser Val Arg 
        195                 200                 205             


Glu Ala Gly Val Pro Leu Gly Leu Pro Ala Pro Gly Ala Arg Arg Arg 
    210                 215                 220                 


Gly Gly Ser Ala Ser Arg Ser Leu Pro Leu Pro Lys Arg Pro Arg Arg 
225                 230                 235                 240 


Gly Ala Ala Pro Glu Pro Glu Arg Thr Pro Val Gly Gln Gly Ser Trp 
                245                 250                 255     


Ala His Pro Gly Arg Thr Arg Gly Pro Ser Asp Arg Gly Phe Cys Val 
            260                 265                 270         


Val Ser Pro Ala Arg Pro Ala Glu Glu Ala Thr Ser Leu Glu Gly Ala 
        275                 280                 285             


Leu Ser Gly Thr Arg His Ser His Pro Ser Val Gly Arg Gln His His 
    290                 295                 300                 


Ala Gly Pro Pro Ser Thr Ser Arg Pro Pro Arg Pro Trp Asp Thr Pro 
305                 310                 315                 320 


Cys Pro Pro Val Tyr Ala Glu Thr Lys His Phe Leu Tyr Ser Ser Gly 
                325                 330                 335     


Asp Lys Glu Gln Leu Arg Pro Ser Phe Leu Leu Ser Ser Leu Arg Pro 
            340                 345                 350         


Ser Leu Thr Gly Ala Arg Arg Leu Val Glu Thr Ile Phe Leu Gly Ser 
        355                 360                 365             


Arg Pro Trp Met Pro Gly Thr Pro Arg Arg Leu Pro Arg Leu Pro Gln 
    370                 375                 380                 


Arg Tyr Trp Gln Met Arg Pro Leu Phe Leu Glu Leu Leu Gly Asn His 
385                 390                 395                 400 


Ala Gln Cys Pro Tyr Gly Val Leu Leu Lys Thr His Cys Pro Leu Arg 
                405                 410                 415     


Ala Ala Val Thr Pro Ala Ala Gly Val Cys Ala Arg Glu Lys Pro Gln 
            420                 425                 430         


Gly Ser Val Ala Ala Pro Glu Glu Glu Asp Thr Asp Pro Arg Arg Leu 
        435                 440                 445             


Val Gln Leu Leu Arg Gln His Ser Ser Pro Trp Gln Val Tyr Gly Phe 
    450                 455                 460                 


Val Arg Ala Cys Leu Arg Arg Leu Val Pro Pro Gly Leu Trp Gly Ser 
465                 470                 475                 480 


Arg His Asn Glu Arg Arg Phe Leu Arg Asn Thr Lys Lys Phe Ile Ser 
                485                 490                 495     


Leu Gly Lys His Ala Lys Leu Ser Leu Gln Glu Leu Thr Trp Lys Met 
            500                 505                 510         


Ser Val Arg Asp Cys Ala Trp Leu Arg Arg Ser Pro Gly Val Gly Cys 
        515                 520                 525             


Val Pro Ala Ala Glu His Arg Leu Arg Glu Glu Ile Leu Ala Lys Phe 
    530                 535                 540                 


Leu His Trp Leu Met Ser Val Tyr Val Val Glu Leu Leu Arg Ser Phe 
545                 550                 555                 560 


Phe Tyr Val Thr Glu Thr Thr Phe Gln Lys Asn Arg Leu Phe Phe Tyr 
                565                 570                 575     


Arg Lys Ser Val Trp Ser Lys Leu Gln Ser Ile Gly Ile Arg Gln His 
            580                 585                 590         


Leu Lys Arg Val Gln Leu Arg Glu Leu Ser Glu Ala Glu Val Arg Gln 
        595                 600                 605             


His Arg Glu Ala Arg Pro Ala Leu Leu Thr Ser Arg Leu Arg Phe Ile 
    610                 615                 620                 


Pro Lys Pro Asp Gly Leu Arg Pro Ile Val Asn Met Asp Tyr Val Val 
625                 630                 635                 640 


Gly Ala Arg Thr Phe Arg Arg Glu Lys Arg Ala Glu Arg Leu Thr Ser 
                645                 650                 655     


Arg Val Lys Ala Leu Phe Ser Val Leu Asn Tyr Glu Arg Ala Arg Arg 
            660                 665                 670         


Pro Gly Leu Leu Gly Ala Ser Val Leu Gly Leu Asp Asp Ile His Arg 
        675                 680                 685             


Ala Trp Arg Thr Phe Val Leu Arg Val Arg Ala Gln Asp Pro Pro Pro 
    690                 695                 700                 


Glu Leu Tyr Phe Val Lys Val Asp Val Thr Gly Ala Tyr Asp Thr Ile 
705                 710                 715                 720 


Pro Gln Asp Arg Leu Thr Glu Val Ile Ala Ser Ile Ile Lys Pro Gln 
                725                 730                 735     


Asn Thr Tyr Cys Val Arg Arg Tyr Ala Val Val Gln Lys Ala Ala His 
            740                 745                 750         


Gly His Val Arg Lys Ala Phe Lys Ser His Val Ser Thr Leu Thr Asp 
        755                 760                 765             


Leu Gln Pro Tyr Met Arg Gln Phe Val Ala His Leu Gln Glu Thr Ser 
    770                 775                 780                 


Pro Leu Arg Asp Ala Val Val Ile Glu Gln Ser Ser Ser Leu Asn Glu 
785                 790                 795                 800 


Ala Ser Ser Gly Leu Phe Asp Val Phe Leu Arg Phe Met Cys His His 
                805                 810                 815     


Ala Val Arg Ile Arg Gly Lys Ser Tyr Val Gln Cys Gln Gly Ile Pro 
            820                 825                 830         


Gln Gly Ser Ile Leu Ser Thr Leu Leu Cys Ser Leu Cys Tyr Gly Asp 
        835                 840                 845             


Met Glu Asn Lys Leu Phe Ala Gly Ile Arg Arg Asp Gly Leu Leu Leu 
    850                 855                 860                 


Arg Leu Val Asp Asp Phe Leu Leu Val Thr Pro His Leu Thr His Ala 
865                 870                 875                 880 


Lys Thr Phe Leu Ser Tyr Ala Arg Thr Ser Ile Arg Ala Ser Leu Thr 
                885                 890                 895     


Phe Asn Arg Gly Phe Lys Ala Gly Arg Asn Met Arg Arg Lys Leu Phe 
            900                 905                 910         


Gly Val Leu Arg Leu Lys Cys His Ser Leu Phe Leu Asp Leu Gln Val 
        915                 920                 925             


Asn Ser Leu Gln Thr Val Cys Thr Asn Ile Tyr Lys Ile Leu Leu Leu 
    930                 935                 940                 


Gln Ala Tyr Arg Phe His Ala Cys Val Leu Gln Leu Pro Phe His Gln 
945                 950                 955                 960 


Gln Val Trp Lys Asn Pro Thr Phe Phe Leu Arg Val Ile Ser Asp Thr 
                965                 970                 975     


Ala Ser Leu Cys Tyr Ser Ile Leu Lys Ala Lys Asn Ala Gly Met Ser 
            980                 985                 990         


Leu Gly Ala Lys Gly Ala Ala Gly  Pro Leu Pro Ser Glu  Ala Val Gln 
        995                 1000                 1005             


Trp Leu  Cys His Gln Ala Phe  Leu Leu Lys Leu Thr  Arg His Arg 
    1010                 1015                 1020             


Val Thr  Tyr Val Pro Leu Leu  Gly Ser Leu Arg Thr  Ala Gln Thr 
    1025                 1030                 1035             


Gln Leu  Ser Arg Lys Leu Pro  Gly Thr Thr Leu Thr  Ala Leu Glu 
    1040                 1045                 1050             


Ala Ala  Ala Asn Pro Ala Leu  Pro Ser Asp Phe Lys  Thr Ile Leu 
    1055                 1060                 1065             


Asp 
    


<210>  10
<211>  3210
<212>  DNA
<213>  Homo sapiens

<400>  10
atgccgcgcg ctccccgctg ccgagccgtg cgctccctgc tgcgcagcca ctaccgcgag       60

gtgctgccgc tggccacgtt cgtgcggcgc ctggggcccc agggctggcg gctggtgcag      120

cgcggggacc cggcggcttt ccgcgcgctg gtggcccagt gcctggtgtg cgtgccctgg      180

gacgcacggc cgccccccgc cgccccctcc ttccgccagg tgtcctgcct gaaggagctg      240

gtggcccgag tgctgcagag gctgtgcgag cgcggcgcga agaacgtgct ggccttcggc      300

ttcgcgctgc tggacggggc ccgcgggggc ccccccgagg ccttcaccac cagcgtgcgc      360

agctacctgc ccaacacggt gaccgacgca ctgcggggga gcggggcgtg ggggctgctg      420

ctgcgccgcg tgggcgacga cgtgctggtt cacctgctgg cacgctgcgc gctctttgtg      480

ctggtggctc ccagctgcgc ctaccaggtg tgcgggccgc cgctgtacca gctcggcgct      540

gccactcagg cccggccccc gccacacgct agtggacccc gaaggcgtct gggatgcgaa      600

cgggcctgga accatagcgt cagggaggcc ggggtccccc tgggcctgcc agccccgggt      660

gcgaggaggc gcgggggcag tgccagccga agtctgccgt tgcccaagag gcccaggcgt      720

ggcgctgccc ctgagccgga gcggacgccc gttgggcagg ggtcctgggc ccacccgggc      780

aggacgcgtg gaccgagtga ccgtggtttc tgtgtggtgt cacctgccag acccgccgaa      840

gaagccacct ctttggaggg tgcgctctct ggcacgcgcc actcccaccc atccgtgggc      900

cgccagcacc acgcgggccc cccatccaca tcgcggccac cacgtccctg ggacacgcct      960

tgtcccccgg tgtacgccga gaccaagcac ttcctctact cctcaggcga caaggagcag     1020

ctgcggccct ccttcctact cagctctctg aggcccagcc tgactggcgc tcggaggctc     1080

gtggagacca tctttctggg ttccaggccc tggatgccag ggactccccg caggttgccc     1140

cgcctgcccc agcgctactg gcaaatgcgg cccctgtttc tggagctgct tgggaaccac     1200

gcgcagtgcc cctacggggt gctcctcaag acgcactgcc cgctgcgagc tgcggtcacc     1260

ccagcagccg gtgtctgtgc ccgggagaag ccccagggct ctgtggcggc ccccgaggag     1320

gaggacacag acccccgtcg cctggtgcag ctgctccgcc agcacagcag cccctggcag     1380

gtgtacggct tcgtgcgggc ctgcctgcgc cggctggtgc ccccaggcct ctggggctcc     1440

aggcacaacg aacgccgctt cctcaggaac accaagaagt tcatctccct ggggaagcat     1500

gccaagctct cgctgcagga gctgacgtgg aagatgagcg tgcgggactg cgcttggctg     1560

cgcaggagcc caggggttgg ctgtgttccg gccgcagagc accgtctgcg tgaggagatc     1620

ctggccaagt tcctgcactg gctgatgagt gtgtacgtcg tcgagctgct caggtctttc     1680

ttttatgtca cggagaccac gtttcaaaag aacaggctct ttttctaccg gaagagtgtc     1740

tggagcaagt tgcaaagcat tggaatcaga cagcacttga agagggtgca gctgcgggag     1800

ctgtcggaag cagaggtcag gcagcatcgg gaagccaggc ccgccctgct gacgtccaga     1860

ctccgcttca tccccaagcc tgacgggctg cggccgattg tgaacatgga ctacgtcgtg     1920

ggagccagaa cgttccgcag agaaaagagg gccgagcgtc tcacctcgag ggtgaaggca     1980

ctgttcagcg tgctcaacta cgagcgggcg cggcgccccg gcctcctggg cgcctctgtg     2040

ctgggcctgg acgatatcca cagggcctgg cgcaccttcg tgctgcgtgt gcgggcccag     2100

gacccgccgc ctgagctgta ctttgtcaag gtggatgtga cgggcgcgta cgacaccatc     2160

ccccaggaca ggctcacgga ggtcatcgcc agcatcatca aaccccagaa cacgtactgc     2220

gtgcgtcggt atgccgtggt ccagaaggcc gcccatgggc acgtccgcaa ggccttcaag     2280

agccacgtct ctaccttgac agacctccag ccgtacatgc gacagttcgt ggctcacctg     2340

caggagacca gcccgctgag ggatgccgtc gtcatcgagc agagctcctc cctgaatgag     2400

gccagcagtg gcctcttcga cgtcttccta cgcttcatgt gccaccacgc cgtgcgcatc     2460

aggggcaagt cctacgtcca gtgccagggg atcccgcagg gctccatcct ctccacgctg     2520

ctctgcagcc tgtgctacgg cgacatggag aacaagctgt ttgcggggat tcggcgggac     2580

gggctgctcc tgcgtttggt ggatgatttc ttgttggtga cacctcacct cacccacgcg     2640

aaaaccttcc tcagctatgc ccggacctcc atcagagcca gtctcacctt caaccgcggc     2700

ttcaaggctg ggaggaacat gcgtcgcaaa ctctttgggg tcttgcggct gaagtgtcac     2760

agcctgtttc tggatttgca ggtgaacagc ctccagacgg tgtgcaccaa catctacaag     2820

atcctcctgc tgcaggcgta caggtttcac gcatgtgtgc tgcagctccc atttcatcag     2880

caagtttgga agaaccccac atttttcctg cgcgtcatct ctgacacggc ctccctctgc     2940

tactccatcc tgaaagccaa gaacgcaggg atgtcgctgg gggccaaggg cgccgccggc     3000

cctctgccct ccgaggccgt gcagtggctg tgccaccaag cattcctgct caagctgact     3060

cgacaccgtg tcacctacgt gccactcctg gggtcactca ggacagccca gacgcagctg     3120

agtcggaagc tcccggggac gacgctgact gccctggagg ccgcagccaa cccggcactg     3180

ccctcagact tcaagaccat cctggactga                                      3210


<210>  11
<211>  317
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Phe Gln Ala Ala Glu Arg Pro Gln Glu Trp Ala Met Glu Gly Pro 
1               5                   10                  15      


Arg Asp Gly Leu Lys Lys Glu Arg Leu Leu Asp Asp Arg His Asp Ser 
            20                  25                  30          


Gly Leu Asp Ser Met Lys Asp Glu Glu Tyr Glu Gln Met Val Lys Glu 
        35                  40                  45              


Leu Gln Glu Ile Arg Leu Glu Pro Gln Glu Val Pro Arg Gly Ser Glu 
    50                  55                  60                  


Pro Trp Lys Gln Gln Leu Thr Glu Asp Gly Asp Ser Phe Leu His Leu 
65                  70                  75                  80  


Ala Ile Ile His Glu Glu Lys Ala Leu Thr Met Glu Val Ile Arg Gln 
                85                  90                  95      


Val Lys Gly Asp Leu Ala Phe Leu Asn Phe Gln Asn Asn Leu Gln Gln 
            100                 105                 110         


Thr Pro Leu His Leu Ala Val Ile Thr Asn Gln Pro Glu Ile Ala Glu 
        115                 120                 125             


Ala Leu Leu Gly Ala Gly Cys Asp Pro Glu Leu Arg Asp Phe Arg Gly 
    130                 135                 140                 


Asn Thr Pro Leu His Leu Ala Cys Glu Gln Gly Cys Leu Ala Ser Val 
145                 150                 155                 160 


Gly Val Leu Thr Gln Ser Cys Thr Thr Pro His Leu His Ser Ile Leu 
                165                 170                 175     


Lys Ala Thr Asn Tyr Asn Gly His Thr Cys Leu His Leu Ala Ser Ile 
            180                 185                 190         


His Gly Tyr Leu Gly Ile Val Glu Leu Leu Val Ser Leu Gly Ala Asp 
        195                 200                 205             


Val Asn Ala Gln Glu Pro Cys Asn Gly Arg Thr Ala Leu His Leu Ala 
    210                 215                 220                 


Val Asp Leu Gln Asn Pro Asp Leu Val Ser Leu Leu Leu Lys Cys Gly 
225                 230                 235                 240 


Ala Asp Val Asn Arg Val Thr Tyr Gln Gly Tyr Ser Pro Tyr Gln Leu 
                245                 250                 255     


Thr Trp Gly Arg Pro Ser Thr Arg Ile Gln Gln Gln Leu Gly Gln Leu 
            260                 265                 270         


Thr Leu Glu Asn Leu Gln Met Leu Pro Glu Ser Glu Asp Glu Glu Ser 
        275                 280                 285             


Tyr Asp Thr Glu Ser Glu Phe Thr Glu Phe Thr Glu Asp Glu Leu Pro 
    290                 295                 300                 


Tyr Asp Asp Cys Val Phe Gly Gly Gln Arg Leu Thr Leu 
305                 310                 315         


<210>  12
<211>  954
<212>  DNA
<213>  Homo sapiens

<400>  12
atgttccagg cggccgagcg cccccaggag tgggccatgg agggcccccg cgacgggctg       60

aagaaggagc ggctactgga cgaccgccac gacagcggcc tggactccat gaaagacgag      120

gagtacgagc agatggtcaa ggagctgcag gagatccgcc tcgagccgca ggaggtgccg      180

cgcggctcgg agccctggaa gcagcagctc accgaggacg gggactcgtt cctgcacttg      240

gccatcatcc atgaagaaaa ggcactgacc atggaagtga tccgccaggt gaagggagac      300

ctggctttcc tcaacttcca gaacaacctg cagcagactc cactccactt ggctgtgatc      360

accaaccagc cagaaattgc tgaggcactt ctgggagctg gctgtgatcc tgagctccga      420

gactttcgag gaaatacccc cctacacctt gcctgtgagc agggctgcct ggccagcgtg      480

ggagtcctga ctcagtcctg caccaccccg cacctccact ccatcctgaa ggctaccaac      540

tacaatggcc acacgtgtct acacttagcc tctatccatg gctacctggg catcgtggag      600

cttttggtgt ccttgggtgc tgatgtcaat gctcaggagc cctgtaatgg ccggactgcc      660

cttcacctcg cagtggacct gcaaaatcct gacctggtgt cactcctgtt gaagtgtggg      720

gctgatgtca acagagttac ctaccagggc tattctccct accagctcac ctggggccgc      780

ccaagcaccc ggatacagca gcagctgggc cagctgacac tagaaaacct tcagatgctg      840

ccagagagtg aggatgagga gagctatgac acagagtcag agttcacgga gttcacagag      900

gacgagctgc cctatgatga ctgtgtgttt ggaggccagc gtctgacgtt atga            954


<210>  13
<211>  719
<212>  PRT
<213>  artificial sequence

<220>
<223>  Fusion protein

<400>  13

Met Phe Gln Ala Ala Glu Arg Pro Gln Glu Trp Ala Met Glu Gly Pro 
1               5                   10                  15      


Arg Asp Gly Leu Lys Lys Glu Arg Leu Leu Asp Asp Arg His Asp Ser 
            20                  25                  30          


Gly Leu Asp Ser Met Lys Asp Glu Glu Tyr Glu Gln Met Val Lys Glu 
        35                  40                  45              


Leu Gln Glu Ile Arg Leu Glu Pro Gln Glu Val Pro Arg Gly Ser Glu 
    50                  55                  60                  


Pro Trp Lys Gln Gln Leu Thr Glu Asp Gly Asp Ser Phe Leu His Leu 
65                  70                  75                  80  


Ala Ile Ile His Glu Glu Lys Ala Leu Thr Met Glu Val Ile Arg Gln 
                85                  90                  95      


Val Lys Gly Asp Leu Ala Phe Leu Asn Phe Gln Asn Asn Leu Gln Gln 
            100                 105                 110         


Thr Pro Leu His Leu Ala Val Ile Thr Asn Gln Pro Glu Ile Ala Glu 
        115                 120                 125             


Ala Leu Leu Gly Ala Gly Cys Asp Pro Glu Leu Arg Asp Phe Arg Gly 
    130                 135                 140                 


Asn Thr Pro Leu His Leu Ala Cys Glu Gln Gly Cys Leu Ala Ser Val 
145                 150                 155                 160 


Gly Val Leu Thr Gln Ser Cys Thr Thr Pro His Leu His Ser Ile Leu 
                165                 170                 175     


Lys Ala Thr Asn Tyr Asn Gly His Thr Cys Leu His Leu Ala Ser Ile 
            180                 185                 190         


His Gly Tyr Leu Gly Ile Val Glu Leu Leu Val Ser Leu Gly Ala Asp 
        195                 200                 205             


Val Asn Ala Gln Glu Pro Cys Asn Gly Arg Thr Ala Leu His Leu Ala 
    210                 215                 220                 


Val Asp Leu Gln Asn Pro Asp Leu Val Ser Leu Leu Leu Lys Cys Gly 
225                 230                 235                 240 


Ala Asp Val Asn Arg Val Thr Tyr Gln Gly Tyr Ser Pro Tyr Gln Leu 
                245                 250                 255     


Thr Trp Gly Arg Pro Ser Thr Arg Ile Gln Gln Gln Leu Gly Gln Leu 
            260                 265                 270         


Thr Leu Glu Asn Leu Gln Met Leu Pro Glu Ser Glu Asp Glu Glu Ser 
        275                 280                 285             


Tyr Asp Thr Glu Ser Glu Phe Thr Glu Phe Thr Glu Asp Glu Leu Pro 
    290                 295                 300                 


Tyr Asp Asp Cys Val Phe Gly Gly Gln Arg Leu Thr Leu Gly Ser Arg 
305                 310                 315                 320 


Gln His His Ala Gly Pro Pro Ser Thr Ser Arg Pro Pro Arg Pro Trp 
                325                 330                 335     


Asp Thr Pro Cys Pro Pro Val Tyr Ala Glu Thr Lys His Phe Leu Tyr 
            340                 345                 350         


Ser Ser Gly Asp Lys Glu Gln Leu Arg Pro Ser Phe Leu Leu Ser Ser 
        355                 360                 365             


Leu Arg Pro Ser Leu Thr Gly Ala Arg Arg Leu Val Glu Thr Ile Phe 
    370                 375                 380                 


Leu Gly Ser Arg Pro Trp Met Pro Gly Thr Pro Arg Arg Leu Pro Arg 
385                 390                 395                 400 


Leu Pro Gln Arg Tyr Trp Gln Met Arg Pro Leu Phe Leu Glu Leu Leu 
                405                 410                 415     


Gly Asn His Ala Gln Cys Pro Tyr Gly Val Leu Leu Lys Thr His Cys 
            420                 425                 430         


Pro Leu Arg Ala Ala Val Thr Pro Ala Ala Gly Val Cys Ala Arg Glu 
        435                 440                 445             


Lys Pro Gln Gly Ser Val Ala Ala Pro Glu Glu Glu Asp Thr Asp Pro 
    450                 455                 460                 


Arg Arg Leu Val Gln Leu Leu Arg Gln His Ser Ser Pro Trp Gln Val 
465                 470                 475                 480 


Tyr Gly Phe Val Arg Ala Cys Leu Arg Arg Leu Val Pro Pro Gly Leu 
                485                 490                 495     


Trp Gly Ser Arg His Asn Glu Arg Arg Phe Leu Arg Asn Thr Lys Lys 
            500                 505                 510         


Phe Ile Ser Leu Gly Lys His Ala Lys Leu Ser Leu Gln Glu Leu Thr 
        515                 520                 525             


Trp Lys Met Ser Val Arg Asp Cys Ala Trp Leu Arg Arg Ser Pro Gly 
    530                 535                 540                 


Val Gly Cys Val Pro Ala Ala Glu His Arg Leu Arg Glu Glu Ile Leu 
545                 550                 555                 560 


Ala Lys Phe Leu His Trp Leu Met Ser Val Tyr Val Val Glu Leu Leu 
                565                 570                 575     


Arg Ser Phe Phe Tyr Val Thr Glu Thr Thr Phe Gln Lys Asn Arg Leu 
            580                 585                 590         


Phe Phe Tyr Arg Lys Ser Val Trp Ser Lys Leu Gln Ser Ile Gly Ile 
        595                 600                 605             


Arg Gln His Leu Lys Arg Val Gln Leu Arg Glu Leu Ser Glu Ala Glu 
    610                 615                 620                 


Val Arg Gln His Arg Glu Ala Arg Pro Ala Leu Leu Thr Ser Arg Leu 
625                 630                 635                 640 


Arg Phe Ile Pro Lys Pro Asp Gly Leu Arg Pro Ile Val Asn Met Asp 
                645                 650                 655     


Tyr Val Val Gly Ala Arg Thr Phe Arg Arg Glu Lys Arg Ala Glu Arg 
            660                 665                 670         


Leu Thr Ser Arg Val Lys Ala Leu Phe Ser Val Leu Asn Tyr Glu Arg 
        675                 680                 685             


Ala Arg Arg Pro Gly Leu Leu Gly Ala Ser Val Leu Gly Leu Asp Asp 
    690                 695                 700                 


Ile His Arg Ala Trp Arg Thr Phe Val Leu Arg Val Arg Ala Gln 
705                 710                 715                 


<210>  14
<211>  2160
<212>  DNA
<213>  artificial sequence

<220>
<223>  fusion construct

<400>  14
atgttccagg cggccgagcg cccccaggag tgggccatgg agggcccccg cgacgggctg       60

aagaaggagc ggctactgga cgaccgccac gacagcggcc tggactccat gaaagacgag      120

gagtacgagc agatggtcaa ggagctgcag gagatccgcc tcgagccgca ggaggtgccg      180

cgcggctcgg agccctggaa gcagcagctc accgaggacg gggactcgtt cctgcacttg      240

gccatcatcc atgaagaaaa ggcactgacc atggaagtga tccgccaggt gaagggagac      300

ctggccttcc tcaacttcca gaacaacctg cagcagactc cactccactt ggctgtgatc      360

accaaccagc cagaaattgc tgaggcactt ctgggagctg gctgtgatcc tgagctccga      420

gactttcgag gaaatacccc cctacacctt gcctgtgagc agggctgcct ggccagcgtg      480

ggagtcctga ctcagtcctg caccaccccg cacctccact ccatcctgaa ggctaccaac      540

tacaatggcc acacgtgtct acacttagcc tctatccatg gctacctggg catcgtggag      600

cttttggtgt ccttgggtgc tgatgtcaat gctcaggagc cctgtaatgg ccggactgcc      660

cttcacctcg cagtggacct gcaaaatcct gacctggtgt cactcctgtt gaagtgtggg      720

gctgatgtca acagagttac ctaccagggc tattctccct accagctcac ctggggccgc      780

ccaagcaccc ggatacagca gcagctgggc cagctgacac tagaaaacct tcagatgctg      840

ccagagagtg aggatgagga gagctatgac acagagtcag agttcacgga gttcacagag      900

gacgagctgc cctatgatga ctgtgtgttt ggaggccagc gtctgacgtt aggatcccgc      960

cagcaccacg cgggcccccc atccacatcg cggccaccac gtccctggga cacgccttgt     1020

cccccggtgt acgccgagac caagcacttc ctctactcct caggcgacaa ggagcagctg     1080

cggccctcct tcctactcag ctctctgagg cccagcctga ctggcgctcg gaggctcgtg     1140

gagaccatct ttctgggttc caggccctgg atgccaggga ctccccgcag gttgccccgc     1200

ctgccccagc gctactggca aatgcggccc ctgtttctgg agctgcttgg gaaccacgcg     1260

cagtgcccct acggggtgct cctcaagacg cactgcccgc tgcgagctgc ggtcacccca     1320

gcagccggtg tctgtgcccg ggagaagccc cagggctctg tggcggcccc cgaggaggag     1380

gacacagacc cccgtcgcct ggtgcagctg ctccgccagc acagcagccc ctggcaggtg     1440

tacggcttcg tgcgggcctg cctgcgccgg ctggtgcccc caggcctctg gggctccagg     1500

cacaacgaac gccgcttcct caggaacacc aagaagttca tctccctggg gaagcatgcc     1560

aagctctcgc tgcaggagct gacgtggaag atgagcgtgc gggactgcgc ttggctgcgc     1620

aggagcccag gggttggctg tgttccggcc gcagagcacc gtctgcgtga ggagatcctg     1680

gccaagttcc tgcactggct gatgagtgtg tacgtcgtcg agctgctcag gtctttcttt     1740

tatgtcacgg agaccacgtt tcaaaagaac aggctctttt tctaccggaa gagtgtctgg     1800

agcaagttgc aaagcattgg aatcagacag cacttgaaga gggtgcagct gcgggagctg     1860

tcggaagcag aggtcaggca gcatcgggaa gccaggcccg ccctgctgac gtccagactc     1920

cgcttcatcc ccaagcctga cgggctgcgg ccgattgtga acatggacta cgtcgtggga     1980

gccagaacgt tccgcagaga aaagagggcc gagcgtctca cctcgagggt gaaggcactg     2040

ttcagcgtgc tcaactacga gcgggcgcgg cgccccggcc tcctgggcgc ctctgtgctg     2100

ggcctggacg atatccacag ggcctggcgc accttcgtgc tgcgtgtgcg ggcccagtga     2160


<210>  15
<211>  365
<212>  PRT
<213>  Homo sapiens

<400>  15

Met Ala Val Met Ala Pro Arg Thr Leu Val Leu Leu Leu Ser Gly Ala 
1               5                   10                  15      


Leu Ala Leu Thr Gln Thr Trp Ala Gly Ser His Ser Met Arg Tyr Phe 
            20                  25                  30          


Phe Thr Ser Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ala 
        35                  40                  45              


Val Gly Tyr Val Asp Asp Thr Gln Phe Val Arg Phe Asp Ser Asp Ala 
    50                  55                  60                  


Ala Ser Gln Arg Met Glu Pro Arg Ala Pro Trp Ile Glu Gln Glu Gly 
65                  70                  75                  80  


Pro Glu Tyr Trp Asp Gly Glu Thr Arg Lys Val Lys Ala His Ser Gln 
                85                  90                  95      


Thr His Arg Val Asp Leu Gly Thr Leu Arg Gly Tyr Tyr Asn Gln Ser 
            100                 105                 110         


Glu Ala Gly Ser His Thr Val Gln Arg Met Tyr Gly Cys Asp Val Gly 
        115                 120                 125             


Ser Asp Trp Arg Phe Leu Arg Gly Tyr His Gln Tyr Ala Tyr Asp Gly 
    130                 135                 140                 


Lys Asp Tyr Ile Ala Leu Lys Glu Asp Leu Arg Ser Trp Thr Ala Ala 
145                 150                 155                 160 


Asp Met Ala Ala Gln Thr Thr Lys His Lys Trp Glu Ala Ala His Val 
                165                 170                 175     


Ala Glu Gln Leu Arg Ala Tyr Leu Glu Gly Thr Cys Val Glu Trp Leu 
            180                 185                 190         


Arg Arg Tyr Leu Glu Asn Gly Lys Glu Thr Leu Gln Arg Thr Asp Ala 
        195                 200                 205             


Pro Lys Thr His Met Thr His His Ala Val Ser Asp His Glu Ala Thr 
    210                 215                 220                 


Leu Arg Cys Trp Ala Leu Ser Phe Tyr Pro Ala Glu Ile Thr Leu Thr 
225                 230                 235                 240 


Trp Gln Arg Asp Gly Glu Asp Gln Thr Gln Asp Thr Glu Leu Val Glu 
                245                 250                 255     


Thr Arg Pro Ala Gly Asp Gly Thr Phe Gln Lys Trp Ala Ala Val Val 
            260                 265                 270         


Val Pro Ser Gly Gln Glu Gln Arg Tyr Thr Cys His Val Gln His Glu 
        275                 280                 285             


Gly Leu Pro Lys Pro Leu Thr Leu Arg Trp Glu Pro Ser Ser Gln Pro 
    290                 295                 300                 


Thr Ile Pro Ile Val Gly Ile Ile Ala Gly Leu Val Leu Phe Gly Ala 
305                 310                 315                 320 


Val Ile Thr Gly Ala Val Val Ala Ala Val Met Trp Arg Arg Lys Ser 
                325                 330                 335     


Ser Asp Arg Lys Gly Gly Ser Tyr Ser Gln Ala Ala Ser Ser Asp Ser 
            340                 345                 350         


Ala Gln Gly Ser Asp Val Ser Leu Thr Ala Cys Lys Val 
        355                 360                 365 


<210>  16
<211>  498
<212>  PRT
<213>  artificial sequence

<220>
<223>  fusion protein

<400>  16

Met Ala His Phe Pro Gly Phe Gly Gln Ser Leu Leu Tyr Gly Tyr Pro 
1               5                   10                  15      


Val Tyr Val Phe Gly Asp Cys Val Gln Ala Asp Trp Cys Pro Val Ser 
            20                  25                  30          


Gly Gly Leu Cys Ser Thr Arg Leu His Arg His Ala Leu Leu Ala Thr 
        35                  40                  45              


Cys Pro Glu His Gln Leu Thr Trp Asp Pro Ile Asp Gly Arg Val Val 
    50                  55                  60                  


Ser Ser Pro Leu Gln Tyr Leu Ile Pro Arg Leu Pro Ser Phe Pro Thr 
65                  70                  75                  80  


Gln Arg Thr Ser Arg Thr Leu Lys Val Leu Thr Pro Pro Thr Thr Pro 
                85                  90                  95      


Val Ser Pro Lys Val Pro Pro Ala Phe Phe Gln Ser Met Arg Lys His 
            100                 105                 110         


Thr Pro Tyr Arg Asn Gly Cys Leu Glu Pro Thr Leu Gly Asp Gln Leu 
        115                 120                 125             


Pro Ser Leu Ala Phe Pro Glu Pro Gly Leu Arg Pro Gln Asn Ile Tyr 
    130                 135                 140                 


Thr Thr Trp Gly Lys Thr Val Val Cys Leu Tyr Leu Tyr Gln Leu Ser 
145                 150                 155                 160 


Pro Pro Met Thr Trp Pro Leu Ile Pro His Val Ile Phe Cys His Pro 
                165                 170                 175     


Arg Gln Leu Gly Ala Phe Leu Thr Lys Val Pro Leu Lys Arg Leu Glu 
            180                 185                 190         


Glu Leu Leu Tyr Lys Met Phe Leu His Thr Gly Thr Val Ile Val Leu 
        195                 200                 205             


Pro Val Asp Asp Leu Pro Thr Thr Met Phe Gln Pro Val Arg Ala Pro 
    210                 215                 220                 


Cys Ile Gln Thr Ala Trp Cys Thr Gly Leu Leu Pro Tyr His Ser Ile 
225                 230                 235                 240 


Leu Thr Thr Pro Gly Leu Ile Trp Thr Phe Asn Asp Gly Ser Pro Met 
                245                 250                 255     


Ile Ser Gly Pro Cys Pro Lys Ala Gly Gln Pro Ser Leu Val Val Gln 
            260                 265                 270         


Ser Ser Leu Leu Ile Phe Glu Lys Phe Gln Thr Lys Ala Phe His Pro 
        275                 280                 285             


Ser Tyr Leu Leu Ser His Gln Leu Ile Gln Tyr Ser Ser Phe His Asn 
    290                 295                 300                 


Leu His Leu Leu Phe Asp Glu Tyr Thr Asn Ile Pro Val Ser Ile Leu 
305                 310                 315                 320 


Phe Asn Lys Glu Glu Ala Asp Asp Asn Gly Asp Gly Ser Val Ser Lys 
                325                 330                 335     


Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp 
            340                 345                 350         


Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly Glu Gly Glu Gly 
        355                 360                 365             


Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly 
    370                 375                 380                 


Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Leu Thr Tyr Gly 
385                 390                 395                 400 


Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys Gln His Asp Phe 
                405                 410                 415     


Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe 
            420                 425                 430         


Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu 
        435                 440                 445             


Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys 
    450                 455                 460                 


Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn Tyr Asn Ser 
465                 470                 475                 480 


His Asn Val Tyr Ile Met Ala Asp Lys Gln Lys Asn Gly Ile Lys Val 
                485                 490                 495     


Asn Phe 
        


<210>  17
<211>  1497
<212>  DNA
<213>  artificial sequence

<220>
<223>  fusion construct

<400>  17
atggcccatt tcccaggatt tggacaaagc ctcctatatg gataccccgt ctacgtgttt       60

ggcgattgtg tacaggccga ttggtgtccc gtctcaggtg gtctatgttc cacccgccta      120

catcgacatg ccctcctggc cacctgtcca gagcaccaac tcacctggga ccccatcgat      180

ggacgcgttg tcagctctcc tctccaatac cttatccctc gcctcccctc cttccccacc      240

cagagaacct caaggaccct caaggtcctt acccctccca ccactcctgt ctcccccaag      300

gttccacctg ccttctttca atcaatgcga aagcacaccc cctaccgaaa tggatgcctg      360

gaaccaaccc tcggggatca gctcccctcc ctcgccttcc ccgaacctgg cctccgtccc      420

caaaacatct acaccacctg gggaaaaacc gtagtatgcc tatacctata ccagctttcc      480

ccacccatga catggccact tataccccat gtcatattct gccaccccag acaattagga      540

gccttcctca ccaaggtgcc tctaaaacga ttagaagaac ttctatacaa aatgttccta      600

cacacaggga cagtcatagt cctcccagtg gacgacctac ccaccacaat gttccaaccc      660

gtgagggctc cctgtatcca gactgcctgg tgtacaggac ttctccccta tcactccatc      720

ttaacaaccc caggtctaat atggaccttc aatgacggct caccaatgat ttccggccct      780

tgccccaaag cagggcagcc atctttagta gttcagtcct ccctattaat cttcgaaaaa      840

ttccaaacca aagccttcca tccctcctat ctactctctc atcagcttat acaatactcc      900

tccttccata accttcacct tctattcgat gaatacacca acatccctgt ctctatttta      960

tttaataaag aagaggcgga tgacaatggc gacggatccg tgagcaaggg cgaggagctg     1020

ttcaccgggg tggtgcccat cctggtcgag ctggacggcg acgtaaacgg ccacaagttc     1080

agcgtgtccg gcgagggcga gggcgatgcc acctacggca agctgaccct gaagttcatc     1140

tgcaccaccg gcaagctgcc cgtgccctgg cccaccctcg tgaccaccct gacctacggc     1200

gtgcagtgct tcagccgcta ccccgaccac atgaagcagc acgacttctt caagtccgcc     1260

atgcccgaag gctacgtcca ggagcgcacc atcttcttca aggacgacgg caactacaag     1320

acccgcgccg aggtgaagtt cgagggcgac accctggtga accgcatcga gctgaagggc     1380

atcgacttca aggaggacgg caacatcctg gggcacaagc tggagtacaa ctacaacagc     1440

cacaacgtct atatcatggc cgacaagcag aagaacggca tcaaggtgaa cttctaa        1497


<210>  18
<211>  24
<212>  DNA
<213>  artificial sequence

<220>
<223>  probe

<400>  18
gatccttctg ggaattccta gatc                                              24


<210>  19
<211>  25
<212>  DNA
<213>  artificial sequence

<220>
<223>  probe

<400>  19
gatccggcag gggaatctcc ctctc                                             25


<210>  20
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  probe

<400>  20
cgcttgatga ctcagccgga a                                                 21


<210>  21
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer

<400>  21
gcaccgtcaa ggctgagaac                                                   20


<210>  22
<211>  19
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer

<400>  22
tggtgaagac gccagtgga                                                    19


<210>  23
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer

<400>  23
cagtgctgct gaaggagatg                                                   20


<210>  24
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer

<400>  24
aacaagtttg gatgggcaac                                                   20


<210>  25
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer

<400>  25
tggcaatgag gatgacttgt                                                   20


<210>  26
<211>  19
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer

<400>  26
tggtggtcgg agattcgta                                                    19


<210>  27
<211>  22
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer

<400>  27
ctcaccagga tgctcacatt ta                                                22


<210>  28
<211>  22
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer

<400>  28
cctccagagg tttgagttct tc                                                22


<210>  29
<211>  19
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer

<400>  29
ggagacttgc ctggtgaaa                                                    19


<210>  30
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer

<400>  30
ctggcttgtt cctcactact c                                                 21


<210>  31
<211>  18
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer

<400>  31
ctggccgtgg ctctcttg                                                     18


<210>  32
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer

<400>  32
ccttggcaaa actgcacctt                                                   20


<210>  33
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer

<400>  33
tttccctgac ctccctctaa                                                   20


<210>  34
<211>  22
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer

<400>  34
cgagacactg gaaggtgaat ta                                                22


<210>  35
<211>  22
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer

<400>  35
ccttgtggct accctggtcc tc                                                22


<210>  36
<211>  22
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer

<400>  36
ctcagcaggt tttgggagtg gt                                                22


<210>  37
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer

<400>  37
accagagcag tgaggtctta                                                   20


<210>  38
<211>  22
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer

<400>  38
ctcctttgtg acaggtgtac tg                                                22


<210>  39
<211>  22
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer

<400>  39
gagtccggag atgcaagtat tc                                                22


<210>  40
<211>  22
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer

<400>  40
cctccagttc ctcacattct tt                                                22


<210>  41
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer

<400>  41
acccacagcc tggataacag                                                   20


<210>  42
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer

<400>  42
actggttgcc atcaaactcc                                                   20


<210>  43
<211>  22
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer

<400>  43
tcaatctctt cagcacaaag ga                                                22


<210>  44
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer

<400>  44
atcacacagg cttccaggtc                                                   20


<210>  45
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer

<400>  45
tctcctgttg tgcttctcca                                                   20


<210>  46
<211>  22
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer

<400>  46
gtcaaagttc atcctgtcct tg                                                22


<210>  47
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer

<400>  47
gccgaattcc ggatctacaa                                                   20


<210>  48
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer

<400>  48
ctcctggagc acctgataaa c                                                 21


<210>  49
<211>  22
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer

<400>  49
cccatgggtt gtgtgtttat tt                                                22


<210>  50
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer

<400>  50
aaaccggcag taactggata g                                                 21


<210>  51
<211>  22
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer

<400>  51
gatccctgac atctggaatc tg                                                22


<210>  52
<211>  22
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer

<400>  52
gaaacatctg gagagaggaa gg                                                22


<210>  53
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer

<400>  53
cagaggagga acgagctaaa                                                   20


<210>  54
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer

<400>  54
ttggacggac aggatgtatg                                                   20


