                         SEQUENCE LISTING

<110>  Dana-Farber Cancer Institute, Inc.
 
<120>  POLYMERASE Q AS A TARGET IN HR-DEFICIENT CANCERS

<130>  D0504.70100WO00

<140>  Not Yet Assigned
<141>  Concurrently Herewith

<150>  US 62/243,330
<151>  2015-10-19

<160>  74    

<170>  PatentIn version 3.5

<210>  1
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  1
cagcgcaucu gugccaaaga a                                                 21


<210>  2
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  2
gaagaaugca gguuuaauat t                                                 21


<210>  3
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  3
aucagcuaga ggcgaucaat t                                                 21


<210>  4
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  4
ggagauugau ggucuacuat t                                                 21


<210>  5
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  5
aggacacaug uaaagggauu gucuatt                                           27


<210>  6
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  6
cgggcctctt tagatataaa t                                                 21


<210>  7
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  7
aagaagaatg caggtttaat a                                                 21


<210>  8
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  8
tatctgctgg aacttttgct ga                                                22


<210>  9
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  9
ctcacaccat ttctttgatg ga                                                22


<210>  10
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  10
ctacaagtga agggagatga gg                                                22


<210>  11
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  11
tcagagggtt tcaccaatcc                                                   20


<210>  12
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  12
catgcatata ggaacccgaa gg                                                22


<210>  13
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  13
caggaccttt ggagaagcag                                                   20


<210>  14
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  14
ggcgttactt aagctagctt g                                                 21


<210>  15
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  15
tgcagtgtac agatgttact ttt                                               23


<210>  16
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  16
tggaggtagc atttcttctc                                                   20


<210>  17
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  17
tcactaggtt ggggttctc                                                    19


<210>  18
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  18
catcagaagc tgactctaga g                                                 21


<210>  19
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  19

Glu Glu Glu Ala Val Glu Glu Arg Arg Asn Met Arg Thr Ile Trp Val 
1               5                   10                  15      


Thr Gly Arg Lys 
            20  


<210>  20
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  20

Glu Glu Ala Val Glu Glu Arg Arg Asn Met Arg Thr Ile Trp Val Thr 
1               5                   10                  15      


Gly Arg Lys Gly 
            20  


<210>  21
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  21

Glu Ala Val Glu Glu Arg Arg Asn Met Arg Thr Ile Trp Val Thr Gly 
1               5                   10                  15      


Arg Lys Gly Leu 
            20  


<210>  22
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  22

Ala Val Glu Glu Arg Arg Asn Met Arg Thr Ile Trp Val Thr Gly Arg 
1               5                   10                  15      


Lys Gly Leu Thr 
            20  


<210>  23
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  23

Val Glu Glu Arg Arg Asn Met Arg Thr Ile Trp Val Thr Gly Arg Lys 
1               5                   10                  15      


Gly Leu Thr Glu 
            20  


<210>  24
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  24

Glu Glu Arg Arg Asn Met Arg Thr Ile Trp Val Thr Gly Arg Lys Gly 
1               5                   10                  15      


Leu Thr Glu Arg 
            20  


<210>  25
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  25

Glu Arg Arg Asn Met Arg Thr Ile Trp Val Thr Gly Arg Lys Gly Leu 
1               5                   10                  15      


Thr Glu Arg Glu 
            20  


<210>  26
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  26

Arg Arg Asn Met Arg Thr Ile Trp Val Thr Gly Arg Lys Gly Leu Thr 
1               5                   10                  15      


Glu Arg Glu Ala 
            20  


<210>  27
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  27

Arg Asn Met Arg Thr Ile Trp Val Thr Gly Arg Lys Gly Leu Thr Glu 
1               5                   10                  15      


Arg Glu Ala Ala 
            20  


<210>  28
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  28

Asn Met Arg Thr Ile Trp Val Thr Gly Arg Lys Gly Leu Thr Glu Arg 
1               5                   10                  15      


Glu Ala Ala Ala 
            20  


<210>  29
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  29

Met Arg Thr Ile Trp Val Thr Gly Arg Lys Gly Leu Thr Glu Arg Glu 
1               5                   10                  15      


Ala Ala Ala Leu 
            20  


<210>  30
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  30

Arg Thr Ile Trp Val Thr Gly Arg Lys Gly Leu Thr Glu Arg Glu Ala 
1               5                   10                  15      


Ala Ala Leu Ile 
            20  


<210>  31
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  31

Thr Ile Trp Val Thr Gly Arg Lys Gly Leu Thr Glu Arg Glu Ala Ala 
1               5                   10                  15      


Ala Leu Ile Val 
            20  


<210>  32
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  32

Asn Phe Leu Asn Ile Ser Arg Leu Gln Glu Lys Thr Gly Thr Tyr Thr 
1               5                   10                  15      


Thr Asn Lys Thr 
            20  


<210>  33
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  33

Phe Leu Asn Ile Ser Arg Leu Gln Glu Lys Thr Gly Thr Tyr Thr Thr 
1               5                   10                  15      


Asn Lys Thr Lys 
            20  


<210>  34
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  34

Leu Asn Ile Ser Arg Leu Gln Glu Lys Thr Gly Thr Tyr Thr Thr Asn 
1               5                   10                  15      


Lys Thr Lys Asn 
            20  


<210>  35
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  35

Asn Ile Ser Arg Leu Gln Glu Lys Thr Gly Thr Tyr Thr Thr Asn Lys 
1               5                   10                  15      


Thr Lys Asn Asn 
            20  


<210>  36
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  36

Ile Ser Arg Leu Gln Glu Lys Thr Gly Thr Tyr Thr Thr Asn Lys Thr 
1               5                   10                  15      


Lys Asn Asn His 
            20  


<210>  37
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  37

Ser Arg Leu Gln Glu Lys Thr Gly Thr Tyr Thr Thr Asn Lys Thr Lys 
1               5                   10                  15      


Asn Asn His Val 
            20  


<210>  38
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  38

Arg Leu Gln Glu Lys Thr Gly Thr Tyr Thr Thr Asn Lys Thr Lys Asn 
1               5                   10                  15      


Asn His Val Ser 
            20  


<210>  39
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  39

Leu Gln Glu Lys Thr Gly Thr Tyr Thr Thr Asn Lys Thr Lys Asn Asn 
1               5                   10                  15      


His Val Ser Asp 
            20  


<210>  40
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  40

Gln Glu Lys Thr Gly Thr Tyr Thr Thr Asn Lys Thr Lys Asn Asn His 
1               5                   10                  15      


Val Ser Asp Leu 
            20  


<210>  41
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  41

Glu Lys Thr Gly Thr Tyr Thr Thr Asn Lys Thr Lys Asn Asn His Val 
1               5                   10                  15      


Ser Asp Leu Gly 
            20  


<210>  42
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  42

Lys Thr Gly Thr Tyr Thr Thr Asn Lys Thr Lys Asn Asn His Val Ser 
1               5                   10                  15      


Asp Leu Gly Leu 
            20  


<210>  43
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  43

Thr Gly Thr Tyr Thr Thr Asn Lys Thr Lys Asn Asn His Val Ser Asp 
1               5                   10                  15      


Leu Gly Leu Val 
            20  


<210>  44
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  44

Gly Thr Tyr Thr Thr Asn Lys Thr Lys Asn Asn His Val Ser Asp Leu 
1               5                   10                  15      


Gly Leu Val Leu 
            20  


<210>  45
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  45

Thr Tyr Thr Thr Asn Lys Thr Lys Asn Asn His Val Ser Asp Leu Gly 
1               5                   10                  15      


Leu Val Leu Cys 
            20  


<210>  46
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  46

Thr Asn Lys Thr Lys Asn Asn His Val Ser Asp Leu Gly Leu Val Leu 
1               5                   10                  15      


Cys Asp Phe Glu 
            20  


<210>  47
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  47

Asn Lys Thr Lys Asn Asn His Val Ser Asp Leu Gly Leu Val Leu Cys 
1               5                   10                  15      


Asp Phe Glu Asp 
            20  


<210>  48
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  48

Lys Thr Lys Asn Asn His Val Ser Asp Leu Gly Leu Val Leu Cys Asp 
1               5                   10                  15      


Phe Glu Asp Ser 
            20  


<210>  49
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  49

Thr Lys Asn Asn His Val Ser Asp Leu Gly Leu Val Leu Cys Asp Phe 
1               5                   10                  15      


Glu Asp Ser Phe 
            20  


<210>  50
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  50

Lys Asn Asn His Val Ser Asp Leu Gly Leu Val Leu Cys Asp Phe Glu 
1               5                   10                  15      


Asp Ser Phe Tyr 
            20  


<210>  51
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  51

Asn Asn His Val Ser Asp Leu Gly Leu Val Leu Cys Asp Phe Glu Asp 
1               5                   10                  15      


Ser Phe Tyr Leu 
            20  


<210>  52
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  52

Asn His Val Ser Asp Leu Gly Leu Val Leu Cys Asp Phe Glu Asp Ser 
1               5                   10                  15      


Phe Tyr Leu Asp 
            20  


<210>  53
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  53

His Val Ser Asp Leu Gly Leu Val Leu Cys Asp Phe Glu Asp Ser Phe 
1               5                   10                  15      


Tyr Leu Asp Thr 
            20  


<210>  54
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  54

Val Ser Asp Leu Gly Leu Val Leu Cys Asp Phe Glu Asp Ser Phe Tyr 
1               5                   10                  15      


Leu Asp Thr Gln 
            20  


<210>  55
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  55

Ser Asp Leu Gly Leu Val Leu Cys Asp Phe Glu Asp Ser Phe Tyr Leu 
1               5                   10                  15      


Asp Thr Gln Ser 
            20  


<210>  56
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  56

Asp Leu Gly Leu Val Leu Cys Asp Phe Glu Asp Ser Phe Tyr Leu Asp 
1               5                   10                  15      


Thr Gln Ser Glu 
            20  


<210>  57
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  57

Leu Gly Leu Val Leu Cys Asp Phe Glu Asp Ser Phe Tyr Leu Asp Thr 
1               5                   10                  15      


Gln Ser Glu Lys 
            20  


<210>  58
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  58

Gly Leu Val Leu Cys Asp Phe Glu Asp Ser Phe Tyr Leu Asp Thr Gln 
1               5                   10                  15      


Ser Glu Lys Ile 
            20  


<210>  59
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  59

Leu Val Leu Cys Asp Phe Glu Asp Ser Phe Tyr Leu Asp Thr Gln Ser 
1               5                   10                  15      


Glu Lys Ile Ile 
            20  


<210>  60
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  60

Val Leu Cys Asp Phe Glu Asp Ser Phe Tyr Leu Asp Thr Gln Ser Glu 
1               5                   10                  15      


Lys Ile Ile Gln 
            20  


<210>  61
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  61

Leu Cys Asp Phe Glu Asp Ser Phe Tyr Leu Asp Thr Gln Ser Glu Lys 
1               5                   10                  15      


Ile Ile Gln Gln 
            20  


<210>  62
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  62

Asn Leu Val Tyr Ser Ala Pro Thr Ser Ala Gly Lys Thr Leu Val Ala 
1               5                   10                  15      


Glu Leu Leu Ile Leu Lys Arg Val 
            20                  


<210>  63
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  63

Lys Met Asp Leu Leu Gly Met Val Val Val Asp Glu Leu His Met Leu 
1               5                   10                  15      


Gly Asp Ser His Arg Gly Tyr Leu 
            20                  


<210>  64
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  64

Asp Cys Phe Ile Leu Met Pro Thr Gly Gly Gly Lys Ser Leu Cys Tyr 
1               5                   10                  15      


Gln Leu Pro Ala Cys Val Ser Pro 
            20                  


<210>  65
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  65

Glu Arg Lys Leu Leu Ala Arg Phe Val Ile Asp Glu Ala His Cys Val 
1               5                   10                  15      


Ser Gln Trp Gly His Asp Phe Arg 
            20                  


<210>  66
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  66

Ser Thr Leu Leu Val Leu Pro Thr Gly Ala Gly Lys Ser Leu Cys Tyr 
1               5                   10                  15      


Gln Leu Pro Ala Leu Leu Tyr Ser 
            20                  


<210>  67
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  67

Gln Leu Pro Pro Val Ala Phe Ala Cys Ile Asp Glu Ala His Cys Leu 
1               5                   10                  15      


Ser Gln Trp Ser His Asn Phe Arg 
            20                  


<210>  68
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  68

Gly Ala Ile Leu Ala Asp Glu Met Gly Leu Gly Lys Thr Leu Gln Cys 
1               5                   10                  15      


Ile Ser Leu Ile Trp Thr Leu Gln 
            20                  


<210>  69
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  69

Lys Asn Ile Lys Phe Asp Leu Leu Ile Cys Asp Glu Gly His Arg Leu 
1               5                   10                  15      


Lys Asn Ser Ala Ile Lys Thr Thr 
            20                  


<210>  70
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  70

Gly Cys Ile Met Ala Asp Glu Met Gly Leu Gly Lys Thr Leu Gln Cys 
1               5                   10                  15      


Ile Thr Leu Met Trp Thr Leu Leu 
            20                  


<210>  71
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  71

Gln Lys Gly Ser Val Gly Leu Val Ile Cys Asp Glu Gly His Arg Leu 
1               5                   10                  15      


Lys Asn Ser Glu Asn Gln Thr Tyr 
            20                  


<210>  72
<211>  30
<212>  PRT
<213>  Caenorhabditis elegans

<400>  72

Ser Leu Thr Arg Phe Leu Asp Thr Ile Asn Leu Gln Leu Val Ile Val 
1               5                   10                  15      


Glu Asn Ile Asp Ala Ile Leu His Asp Thr Val Tyr His Lys 
            20                  25                  30  


<210>  73
<211>  38
<212>  PRT
<213>  Homo sapiens

<400>  73

Thr Tyr Thr Thr Asn Lys Thr Lys Asn Asn His Val Ser Asp Leu Gly 
1               5                   10                  15      


Leu Val Leu Cys Asp Phe Glu Asp Ser Phe Tyr Leu Asp Thr Gln Ser 
            20                  25                  30          


Glu Lys Ile Ile Gln Gln 
        35              


<210>  74
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  74
gttagcaggt accgagcaac aattcactgg                                        30


