                         SEQUENCE LISTING

<110>  Merus B.V.
       Instituci Catalana de Recerca I Estudis Avanats
       Koninklijke Nederlandse Akademie van Wetenschappen
       OcellO B.V.
       Institute for Research in Biomedicine (IRB Barcelona)
 
<120>  Binding molecules that inhibit cancer growth.

<130>  P108305PC00

<140>  PCT/NL2016/050726
<141>  2016-10-21

<150>  EP 15191343.1
<151>  2015-10-23

<150>  16168647.2
<151>  2016-05-06

<160>  181   

<170>  PatentIn version 3.5

<210>  1
<211>  907
<212>  PRT
<213>  Homo sapiens


<220>
<221>  SIGNAL
<222>  (1)..(20)

<220>
<221>  DOMAIN
<222>  (21)..(69)
<223>  N-region

<220>
<221>  DOMAIN
<222>  (70)..(93)
<223>  LRR1

<220>
<221>  DOMAIN
<222>  (94)..(117)
<223>  LRR2

<220>
<221>  DOMAIN
<222>  (118)..(141)
<223>  LRR3

<220>
<221>  DOMAIN
<222>  (142)..(165)
<223>  LRR4

<220>
<221>  DOMAIN
<222>  (166)..(189)
<223>  LRR5

<220>
<221>  DOMAIN
<222>  (190)..(213)
<223>  LRR6

<220>
<221>  DOMAIN
<222>  (214)..(238)
<223>  LRR7

<220>
<221>  DOMAIN
<222>  (239)..(257)
<223>  LRR8

<220>
<221>  DOMAIN
<222>  (258)..(284)
<223>  LRR9

<220>
<221>  DOMAIN
<222>  (285)..(308)
<223>  LRR10

<220>
<221>  DOMAIN
<222>  (309)..(331)
<223>  LRR11

<220>
<221>  DOMAIN
<222>  (332)..(355)
<223>  LRR12

<220>
<221>  DOMAIN
<222>  (356)..(377)
<223>  LRR13

<220>
<221>  DOMAIN
<222>  (378)..(400)
<223>  LRR14

<220>
<221>  DOMAIN
<222>  (401)..(425)
<223>  LRR15

<220>
<221>  DOMAIN
<222>  (426)..(448)
<223>  LRR16

<220>
<221>  DOMAIN
<222>  (449)..(472)
<223>  LRR17

<220>
<221>  DOMAIN
<222>  (473)..(560)
<223>  CRL region

<220>
<221>  DOMAIN
<222>  (561)..(582)
<223>  predicted TM1

<220>
<221>  DOMAIN
<222>  (592)..(617)
<223>  predicted TM2

<220>
<221>  DOMAIN
<222>  (639)..(661)
<223>  predicted TM3

<220>
<221>  DOMAIN
<222>  (680)..(704)
<223>  predicted TM4

<220>
<221>  DOMAIN
<222>  (723)..(747)
<223>  predicted TM5

<220>
<221>  DOMAIN
<222>  (766)..(789)
<223>  predicted TM6

<220>
<221>  DOMAIN
<222>  (801)..(824)
<223>  predicted TM7

<220>
<221>  DOMAIN
<222>  (825)..(907)
<223>  C-terminal tail

<400>  1

Met Asp Thr Ser Arg Leu Gly Val Leu Leu Ser Leu Pro Val Leu Leu 
1               5                   10                  15      


Gln Leu Ala Thr Gly Gly Ser Ser Pro Arg Ser Gly Val Leu Leu Arg 
            20                  25                  30          


Gly Cys Pro Thr His Cys His Cys Glu Pro Asp Gly Arg Met Leu Leu 
        35                  40                  45              


Arg Val Asp Cys Ser Asp Leu Gly Leu Ser Glu Leu Pro Ser Asn Leu 
    50                  55                  60                  


Ser Val Phe Thr Ser Tyr Leu Asp Leu Ser Met Asn Asn Ile Ser Gln 
65                  70                  75                  80  


Leu Leu Pro Asn Pro Leu Pro Ser Leu Arg Phe Leu Glu Glu Leu Arg 
                85                  90                  95      


Leu Ala Gly Asn Ala Leu Thr Tyr Ile Pro Lys Gly Ala Phe Thr Gly 
            100                 105                 110         


Leu Tyr Ser Leu Lys Val Leu Met Leu Gln Asn Asn Gln Leu Arg His 
        115                 120                 125             


Val Pro Thr Glu Ala Leu Gln Asn Leu Arg Ser Leu Gln Ser Leu Arg 
    130                 135                 140                 


Leu Asp Ala Asn His Ile Ser Tyr Val Pro Pro Ser Cys Phe Ser Gly 
145                 150                 155                 160 


Leu His Ser Leu Arg His Leu Trp Leu Asp Asp Asn Ala Leu Thr Glu 
                165                 170                 175     


Ile Pro Val Gln Ala Phe Arg Ser Leu Ser Ala Leu Gln Ala Met Thr 
            180                 185                 190         


Leu Ala Leu Asn Lys Ile His His Ile Pro Asp Tyr Ala Phe Gly Asn 
        195                 200                 205             


Leu Ser Ser Leu Val Val Leu His Leu His Asn Asn Arg Ile His Ser 
    210                 215                 220                 


Leu Gly Lys Lys Cys Phe Asp Gly Leu His Ser Leu Glu Thr Leu Asp 
225                 230                 235                 240 


Leu Asn Tyr Asn Asn Leu Asp Glu Phe Pro Thr Ala Ile Arg Thr Leu 
                245                 250                 255     


Ser Asn Leu Lys Glu Leu Gly Phe His Ser Asn Asn Ile Arg Ser Ile 
            260                 265                 270         


Pro Glu Lys Ala Phe Val Gly Asn Pro Ser Leu Ile Thr Ile His Phe 
        275                 280                 285             


Tyr Asp Asn Pro Ile Gln Phe Val Gly Arg Ser Ala Phe Gln His Leu 
    290                 295                 300                 


Pro Glu Leu Arg Thr Leu Thr Leu Asn Gly Ala Ser Gln Ile Thr Glu 
305                 310                 315                 320 


Phe Pro Asp Leu Thr Gly Thr Ala Asn Leu Glu Ser Leu Thr Leu Thr 
                325                 330                 335     


Gly Ala Gln Ile Ser Ser Leu Pro Gln Thr Val Cys Asn Gln Leu Pro 
            340                 345                 350         


Asn Leu Gln Val Leu Asp Leu Ser Tyr Asn Leu Leu Glu Asp Leu Pro 
        355                 360                 365             


Ser Phe Ser Val Cys Gln Lys Leu Gln Lys Ile Asp Leu Arg His Asn 
    370                 375                 380                 


Glu Ile Tyr Glu Ile Lys Val Asp Thr Phe Gln Gln Leu Leu Ser Leu 
385                 390                 395                 400 


Arg Ser Leu Asn Leu Ala Trp Asn Lys Ile Ala Ile Ile His Pro Asn 
                405                 410                 415     


Ala Phe Ser Thr Leu Pro Ser Leu Ile Lys Leu Asp Leu Ser Ser Asn 
            420                 425                 430         


Leu Leu Ser Ser Phe Pro Ile Thr Gly Leu His Gly Leu Thr His Leu 
        435                 440                 445             


Lys Leu Thr Gly Asn His Ala Leu Gln Ser Leu Ile Ser Ser Glu Asn 
    450                 455                 460                 


Phe Pro Glu Leu Lys Val Ile Glu Met Pro Tyr Ala Tyr Gln Cys Cys 
465                 470                 475                 480 


Ala Phe Gly Val Cys Glu Asn Ala Tyr Lys Ile Ser Asn Gln Trp Asn 
                485                 490                 495     


Lys Gly Asp Asn Ser Ser Met Asp Asp Leu His Lys Lys Asp Ala Gly 
            500                 505                 510         


Met Phe Gln Ala Gln Asp Glu Arg Asp Leu Glu Asp Phe Leu Leu Asp 
        515                 520                 525             


Phe Glu Glu Asp Leu Lys Ala Leu His Ser Val Gln Cys Ser Pro Ser 
    530                 535                 540                 


Pro Gly Pro Phe Lys Pro Cys Glu His Leu Leu Asp Gly Trp Leu Ile 
545                 550                 555                 560 


Arg Ile Gly Val Trp Thr Ile Ala Val Leu Ala Leu Thr Cys Asn Ala 
                565                 570                 575     


Leu Val Thr Ser Thr Val Phe Arg Ser Pro Leu Tyr Ile Ser Pro Ile 
            580                 585                 590         


Lys Leu Leu Ile Gly Val Ile Ala Ala Val Asn Met Leu Thr Gly Val 
        595                 600                 605             


Ser Ser Ala Val Leu Ala Gly Val Asp Ala Phe Thr Phe Gly Ser Phe 
    610                 615                 620                 


Ala Arg His Gly Ala Trp Trp Glu Asn Gly Val Gly Cys His Val Ile 
625                 630                 635                 640 


Gly Phe Leu Ser Ile Phe Ala Ser Glu Ser Ser Val Phe Leu Leu Thr 
                645                 650                 655     


Leu Ala Ala Leu Glu Arg Gly Phe Ser Val Lys Tyr Ser Ala Lys Phe 
            660                 665                 670         


Glu Thr Lys Ala Pro Phe Ser Ser Leu Lys Val Ile Ile Leu Leu Cys 
        675                 680                 685             


Ala Leu Leu Ala Leu Thr Met Ala Ala Val Pro Leu Leu Gly Gly Ser 
    690                 695                 700                 


Lys Tyr Gly Ala Ser Pro Leu Cys Leu Pro Leu Pro Phe Gly Glu Pro 
705                 710                 715                 720 


Ser Thr Met Gly Tyr Met Val Ala Leu Ile Leu Leu Asn Ser Leu Cys 
                725                 730                 735     


Phe Leu Met Met Thr Ile Ala Tyr Thr Lys Leu Tyr Cys Asn Leu Asp 
            740                 745                 750         


Lys Gly Asp Leu Glu Asn Ile Trp Asp Cys Ser Met Val Lys His Ile 
        755                 760                 765             


Ala Leu Leu Leu Phe Thr Asn Cys Ile Leu Asn Cys Pro Val Ala Phe 
    770                 775                 780                 


Leu Ser Phe Ser Ser Leu Ile Asn Leu Thr Phe Ile Ser Pro Glu Val 
785                 790                 795                 800 


Ile Lys Phe Ile Leu Leu Val Val Val Pro Leu Pro Ala Cys Leu Asn 
                805                 810                 815     


Pro Leu Leu Tyr Ile Leu Phe Asn Pro His Phe Lys Glu Asp Leu Val 
            820                 825                 830         


Ser Leu Arg Lys Gln Thr Tyr Val Trp Thr Arg Ser Lys His Pro Ser 
        835                 840                 845             


Leu Met Ser Ile Asn Ser Asp Asp Val Glu Lys Gln Ser Cys Asp Ser 
    850                 855                 860                 


Thr Gln Ala Leu Val Thr Phe Thr Ser Ser Ser Ile Thr Tyr Asp Leu 
865                 870                 875                 880 


Pro Pro Ser Ser Val Pro Ser Pro Ala Tyr Pro Val Thr Glu Ser Cys 
                885                 890                 895     


His Leu Ser Ser Val Ala Phe Val Pro Cys Leu 
            900                 905         


<210>  2
<211>  1210
<212>  PRT
<213>  Homo sapiens


<220>
<221>  SIGNAL
<222>  (1)..(24)

<220>
<221>  DOMAIN
<222>  (25)..(660)
<223>  Extracellular domain

<220>
<221>  DOMAIN
<222>  (661)..(676)
<223>  predicted transmembrane domain

<220>
<221>  DOMAIN
<222>  (677)..(1210)
<223>  intracellular tyrosine kinase and C-terminal tail

<400>  2

Met Arg Pro Ser Gly Thr Ala Gly Ala Ala Leu Leu Ala Leu Leu Ala 
1               5                   10                  15      


Ala Leu Cys Pro Ala Ser Arg Ala Leu Glu Glu Lys Lys Val Cys Gln 
            20                  25                  30          


Gly Thr Ser Asn Lys Leu Thr Gln Leu Gly Thr Phe Glu Asp His Phe 
        35                  40                  45              


Leu Ser Leu Gln Arg Met Phe Asn Asn Cys Glu Val Val Leu Gly Asn 
    50                  55                  60                  


Leu Glu Ile Thr Tyr Val Gln Arg Asn Tyr Asp Leu Ser Phe Leu Lys 
65                  70                  75                  80  


Thr Ile Gln Glu Val Ala Gly Tyr Val Leu Ile Ala Leu Asn Thr Val 
                85                  90                  95      


Glu Arg Ile Pro Leu Glu Asn Leu Gln Ile Ile Arg Gly Asn Met Tyr 
            100                 105                 110         


Tyr Glu Asn Ser Tyr Ala Leu Ala Val Leu Ser Asn Tyr Asp Ala Asn 
        115                 120                 125             


Lys Thr Gly Leu Lys Glu Leu Pro Met Arg Asn Leu Gln Glu Ile Leu 
    130                 135                 140                 


His Gly Ala Val Arg Phe Ser Asn Asn Pro Ala Leu Cys Asn Val Glu 
145                 150                 155                 160 


Ser Ile Gln Trp Arg Asp Ile Val Ser Ser Asp Phe Leu Ser Asn Met 
                165                 170                 175     


Ser Met Asp Phe Gln Asn His Leu Gly Ser Cys Gln Lys Cys Asp Pro 
            180                 185                 190         


Ser Cys Pro Asn Gly Ser Cys Trp Gly Ala Gly Glu Glu Asn Cys Gln 
        195                 200                 205             


Lys Leu Thr Lys Ile Ile Cys Ala Gln Gln Cys Ser Gly Arg Cys Arg 
    210                 215                 220                 


Gly Lys Ser Pro Ser Asp Cys Cys His Asn Gln Cys Ala Ala Gly Cys 
225                 230                 235                 240 


Thr Gly Pro Arg Glu Ser Asp Cys Leu Val Cys Arg Lys Phe Arg Asp 
                245                 250                 255     


Glu Ala Thr Cys Lys Asp Thr Cys Pro Pro Leu Met Leu Tyr Asn Pro 
            260                 265                 270         


Thr Thr Tyr Gln Met Asp Val Asn Pro Glu Gly Lys Tyr Ser Phe Gly 
        275                 280                 285             


Ala Thr Cys Val Lys Lys Cys Pro Arg Asn Tyr Val Val Thr Asp His 
    290                 295                 300                 


Gly Ser Cys Val Arg Ala Cys Gly Ala Asp Ser Tyr Glu Met Glu Glu 
305                 310                 315                 320 


Asp Gly Val Arg Lys Cys Lys Lys Cys Glu Gly Pro Cys Arg Lys Val 
                325                 330                 335     


Cys Asn Gly Ile Gly Ile Gly Glu Phe Lys Asp Ser Leu Ser Ile Asn 
            340                 345                 350         


Ala Thr Asn Ile Lys His Phe Lys Asn Cys Thr Ser Ile Ser Gly Asp 
        355                 360                 365             


Leu His Ile Leu Pro Val Ala Phe Arg Gly Asp Ser Phe Thr His Thr 
    370                 375                 380                 


Pro Pro Leu Asp Pro Gln Glu Leu Asp Ile Leu Lys Thr Val Lys Glu 
385                 390                 395                 400 


Ile Thr Gly Phe Leu Leu Ile Gln Ala Trp Pro Glu Asn Arg Thr Asp 
                405                 410                 415     


Leu His Ala Phe Glu Asn Leu Glu Ile Ile Arg Gly Arg Thr Lys Gln 
            420                 425                 430         


His Gly Gln Phe Ser Leu Ala Val Val Ser Leu Asn Ile Thr Ser Leu 
        435                 440                 445             


Gly Leu Arg Ser Leu Lys Glu Ile Ser Asp Gly Asp Val Ile Ile Ser 
    450                 455                 460                 


Gly Asn Lys Asn Leu Cys Tyr Ala Asn Thr Ile Asn Trp Lys Lys Leu 
465                 470                 475                 480 


Phe Gly Thr Ser Gly Gln Lys Thr Lys Ile Ile Ser Asn Arg Gly Glu 
                485                 490                 495     


Asn Ser Cys Lys Ala Thr Gly Gln Val Cys His Ala Leu Cys Ser Pro 
            500                 505                 510         


Glu Gly Cys Trp Gly Pro Glu Pro Arg Asp Cys Val Ser Cys Arg Asn 
        515                 520                 525             


Val Ser Arg Gly Arg Glu Cys Val Asp Lys Cys Asn Leu Leu Glu Gly 
    530                 535                 540                 


Glu Pro Arg Glu Phe Val Glu Asn Ser Glu Cys Ile Gln Cys His Pro 
545                 550                 555                 560 


Glu Cys Leu Pro Gln Ala Met Asn Ile Thr Cys Thr Gly Arg Gly Pro 
                565                 570                 575     


Asp Asn Cys Ile Gln Cys Ala His Tyr Ile Asp Gly Pro His Cys Val 
            580                 585                 590         


Lys Thr Cys Pro Ala Gly Val Met Gly Glu Asn Asn Thr Leu Val Trp 
        595                 600                 605             


Lys Tyr Ala Asp Ala Gly His Val Cys His Leu Cys His Pro Asn Cys 
    610                 615                 620                 


Thr Tyr Gly Cys Thr Gly Pro Gly Leu Glu Gly Cys Pro Thr Asn Gly 
625                 630                 635                 640 


Pro Lys Ile Pro Ser Ile Ala Thr Gly Met Val Gly Ala Leu Leu Leu 
                645                 650                 655     


Leu Leu Val Val Ala Leu Gly Ile Gly Leu Phe Met Arg Arg Arg His 
            660                 665                 670         


Ile Val Arg Lys Arg Thr Leu Arg Arg Leu Leu Gln Glu Arg Glu Leu 
        675                 680                 685             


Val Glu Pro Leu Thr Pro Ser Gly Glu Ala Pro Asn Gln Ala Leu Leu 
    690                 695                 700                 


Arg Ile Leu Lys Glu Thr Glu Phe Lys Lys Ile Lys Val Leu Gly Ser 
705                 710                 715                 720 


Gly Ala Phe Gly Thr Val Tyr Lys Gly Leu Trp Ile Pro Glu Gly Glu 
                725                 730                 735     


Lys Val Lys Ile Pro Val Ala Ile Lys Glu Leu Arg Glu Ala Thr Ser 
            740                 745                 750         


Pro Lys Ala Asn Lys Glu Ile Leu Asp Glu Ala Tyr Val Met Ala Ser 
        755                 760                 765             


Val Asp Asn Pro His Val Cys Arg Leu Leu Gly Ile Cys Leu Thr Ser 
    770                 775                 780                 


Thr Val Gln Leu Ile Thr Gln Leu Met Pro Phe Gly Cys Leu Leu Asp 
785                 790                 795                 800 


Tyr Val Arg Glu His Lys Asp Asn Ile Gly Ser Gln Tyr Leu Leu Asn 
                805                 810                 815     


Trp Cys Val Gln Ile Ala Lys Gly Met Asn Tyr Leu Glu Asp Arg Arg 
            820                 825                 830         


Leu Val His Arg Asp Leu Ala Ala Arg Asn Val Leu Val Lys Thr Pro 
        835                 840                 845             


Gln His Val Lys Ile Thr Asp Phe Gly Leu Ala Lys Leu Leu Gly Ala 
    850                 855                 860                 


Glu Glu Lys Glu Tyr His Ala Glu Gly Gly Lys Val Pro Ile Lys Trp 
865                 870                 875                 880 


Met Ala Leu Glu Ser Ile Leu His Arg Ile Tyr Thr His Gln Ser Asp 
                885                 890                 895     


Val Trp Ser Tyr Gly Val Thr Val Trp Glu Leu Met Thr Phe Gly Ser 
            900                 905                 910         


Lys Pro Tyr Asp Gly Ile Pro Ala Ser Glu Ile Ser Ser Ile Leu Glu 
        915                 920                 925             


Lys Gly Glu Arg Leu Pro Gln Pro Pro Ile Cys Thr Ile Asp Val Tyr 
    930                 935                 940                 


Met Ile Met Val Lys Cys Trp Met Ile Asp Ala Asp Ser Arg Pro Lys 
945                 950                 955                 960 


Phe Arg Glu Leu Ile Ile Glu Phe Ser Lys Met Ala Arg Asp Pro Gln 
                965                 970                 975     


Arg Tyr Leu Val Ile Gln Gly Asp Glu Arg Met His Leu Pro Ser Pro 
            980                 985                 990         


Thr Asp Ser Asn Phe Tyr Arg Ala  Leu Met Asp Glu Glu  Asp Met Asp 
        995                 1000                 1005             


Asp Val  Val Asp Ala Asp Glu  Tyr Leu Ile Pro Gln  Gln Gly Phe 
    1010                 1015                 1020             


Phe Ser  Ser Pro Ser Thr Ser  Arg Thr Pro Leu Leu  Ser Ser Leu 
    1025                 1030                 1035             


Ser Ala  Thr Ser Asn Asn Ser  Thr Val Ala Cys Ile  Asp Arg Asn 
    1040                 1045                 1050             


Gly Leu  Gln Ser Cys Pro Ile  Lys Glu Asp Ser Phe  Leu Gln Arg 
    1055                 1060                 1065             


Tyr Ser  Ser Asp Pro Thr Gly  Ala Leu Thr Glu Asp  Ser Ile Asp 
    1070                 1075                 1080             


Asp Thr  Phe Leu Pro Val Pro  Glu Tyr Ile Asn Gln  Ser Val Pro 
    1085                 1090                 1095             


Lys Arg  Pro Ala Gly Ser Val  Gln Asn Pro Val Tyr  His Asn Gln 
    1100                 1105                 1110             


Pro Leu  Asn Pro Ala Pro Ser  Arg Asp Pro His Tyr  Gln Asp Pro 
    1115                 1120                 1125             


His Ser  Thr Ala Val Gly Asn  Pro Glu Tyr Leu Asn  Thr Val Gln 
    1130                 1135                 1140             


Pro Thr  Cys Val Asn Ser Thr  Phe Asp Ser Pro Ala  His Trp Ala 
    1145                 1150                 1155             


Gln Lys  Gly Ser His Gln Ile  Ser Leu Asp Asn Pro  Asp Tyr Gln 
    1160                 1165                 1170             


Gln Asp  Phe Phe Pro Lys Glu  Ala Lys Pro Asn Gly  Ile Phe Lys 
    1175                 1180                 1185             


Gly Ser  Thr Ala Glu Asn Ala  Glu Tyr Leu Arg Val  Ala Pro Gln 
    1190                 1195                 1200             


Ser Ser  Glu Phe Ile Gly Ala  
    1205                 1210 


<210>  3
<211>  997
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence full length hLGR4-FLAG-HA insert


<220>
<221>  SIGNAL
<222>  (1)..(24)

<220>
<221>  MISC_FEATURE
<222>  (952)..(953)
<223>  linker

<220>
<221>  MISC_FEATURE
<222>  (954)..(961)
<223>  FLG tag

<220>
<221>  MISC_FEATURE
<222>  (962)..(964)
<223>  linker

<220>
<221>  MISC_FEATURE
<222>  (965)..(972)
<223>  FLAG tag

<220>
<221>  MISC_FEATURE
<222>  (973)..(976)
<223>  linker

<220>
<221>  MISC_FEATURE
<222>  (977)..(985)
<223>  HA tag

<220>
<221>  MISC_FEATURE
<222>  (986)..(988)
<223>  linker

<220>
<221>  MISC_FEATURE
<222>  (989)..(997)
<223>  HA tag

<400>  3

Met Ala Gly Pro Leu Gly Leu Leu Cys Phe Leu Ala Leu Gly Leu Leu 
1               5                   10                  15      


Gly Ser Ala Gly Pro Ser Gly Ala Ala Pro Pro Leu Cys Ala Ala Pro 
            20                  25                  30          


Cys Ser Cys Asp Gly Asp Arg Arg Val Asp Cys Ser Gly Lys Gly Leu 
        35                  40                  45              


Thr Ala Val Pro Glu Gly Leu Ser Ala Phe Thr Gln Ala Leu Asp Ile 
    50                  55                  60                  


Ser Met Asn Asn Ile Thr Gln Leu Pro Glu Asp Ala Phe Lys Asn Phe 
65                  70                  75                  80  


Pro Phe Leu Glu Glu Leu Gln Leu Ala Gly Asn Asp Leu Ser Phe Ile 
                85                  90                  95      


His Pro Lys Ala Leu Ser Gly Leu Lys Glu Leu Lys Val Leu Thr Leu 
            100                 105                 110         


Gln Asn Asn Gln Leu Lys Thr Val Pro Ser Glu Ala Ile Arg Gly Leu 
        115                 120                 125             


Ser Ala Leu Gln Ser Leu Arg Leu Asp Ala Asn His Ile Thr Ser Val 
    130                 135                 140                 


Pro Glu Asp Ser Phe Glu Gly Leu Val Gln Leu Arg His Leu Trp Leu 
145                 150                 155                 160 


Asp Asp Asn Ser Leu Thr Glu Val Pro Val His Pro Leu Ser Asn Leu 
                165                 170                 175     


Pro Thr Leu Gln Ala Leu Thr Leu Ala Leu Asn Lys Ile Ser Ser Ile 
            180                 185                 190         


Pro Asp Phe Ala Phe Thr Asn Leu Ser Ser Leu Val Val Leu His Leu 
        195                 200                 205             


His Asn Asn Lys Ile Arg Ser Leu Ser Gln His Cys Phe Asp Gly Leu 
    210                 215                 220                 


Asp Asn Leu Glu Thr Leu Asp Leu Asn Tyr Asn Asn Leu Gly Glu Phe 
225                 230                 235                 240 


Pro Gln Ala Ile Lys Ala Leu Pro Ser Leu Lys Glu Leu Gly Phe His 
                245                 250                 255     


Ser Asn Ser Ile Ser Val Ile Pro Asp Gly Ala Phe Asp Gly Asn Pro 
            260                 265                 270         


Leu Leu Arg Thr Ile His Leu Tyr Asp Asn Pro Leu Ser Phe Val Gly 
        275                 280                 285             


Asn Ser Ala Phe His Asn Leu Ser Asp Leu His Ser Leu Val Ile Arg 
    290                 295                 300                 


Gly Ala Ser Met Val Gln Gln Phe Pro Asn Leu Thr Gly Thr Val His 
305                 310                 315                 320 


Leu Glu Ser Leu Thr Leu Thr Gly Thr Lys Ile Ser Ser Ile Pro Asn 
                325                 330                 335     


Asn Leu Cys Gln Glu Gln Lys Met Leu Arg Thr Leu Asp Leu Ser Tyr 
            340                 345                 350         


Asn Asn Ile Arg Asp Leu Pro Ser Phe Asn Gly Cys His Ala Leu Glu 
        355                 360                 365             


Glu Ile Ser Leu Gln Arg Asn Gln Ile Tyr Gln Ile Lys Glu Gly Thr 
    370                 375                 380                 


Phe Gln Gly Leu Ile Ser Leu Arg Ile Leu Asp Leu Ser Arg Asn Leu 
385                 390                 395                 400 


Ile His Glu Ile His Ser Arg Ala Phe Ala Thr Leu Gly Pro Ile Thr 
                405                 410                 415     


Asn Leu Asp Val Ser Phe Asn Glu Leu Thr Ser Phe Pro Thr Glu Gly 
            420                 425                 430         


Leu Asn Gly Leu Asn Gln Leu Lys Leu Val Gly Asn Phe Lys Leu Lys 
        435                 440                 445             


Glu Ala Leu Ala Ala Lys Asp Phe Val Asn Leu Arg Ser Leu Ser Val 
    450                 455                 460                 


Pro Tyr Ala Tyr Gln Cys Cys Ala Phe Trp Gly Cys Asp Ser Tyr Ala 
465                 470                 475                 480 


Asn Leu Asn Thr Glu Asp Asn Ser Leu Gln Asp His Ser Val Ala Gln 
                485                 490                 495     


Glu Lys Gly Thr Ala Asp Ala Ala Asn Val Thr Ser Thr Leu Glu Asn 
            500                 505                 510         


Glu Glu His Ser Gln Ile Ile Ile His Cys Thr Pro Ser Thr Gly Ala 
        515                 520                 525             


Phe Lys Pro Cys Glu Tyr Leu Leu Gly Ser Trp Met Ile Arg Leu Thr 
    530                 535                 540                 


Val Trp Phe Ile Phe Leu Val Ala Leu Phe Phe Asn Leu Leu Val Ile 
545                 550                 555                 560 


Leu Thr Thr Phe Ala Ser Cys Thr Ser Leu Pro Ser Ser Lys Leu Phe 
                565                 570                 575     


Ile Gly Leu Ile Ser Val Ser Asn Leu Phe Met Gly Ile Tyr Thr Gly 
            580                 585                 590         


Ile Leu Thr Phe Leu Asp Ala Val Ser Trp Gly Arg Phe Ala Glu Phe 
        595                 600                 605             


Gly Ile Trp Trp Glu Thr Gly Ser Gly Cys Lys Val Ala Gly Phe Leu 
    610                 615                 620                 


Ala Val Phe Ser Ser Glu Ser Ala Ile Phe Leu Leu Met Leu Ala Thr 
625                 630                 635                 640 


Val Glu Arg Ser Leu Ser Ala Lys Asp Ile Met Lys Asn Gly Lys Ser 
                645                 650                 655     


Asn His Leu Lys Gln Phe Arg Val Ala Ala Leu Leu Ala Phe Leu Gly 
            660                 665                 670         


Ala Thr Val Ala Gly Cys Phe Pro Leu Phe His Arg Gly Glu Tyr Ser 
        675                 680                 685             


Ala Ser Pro Leu Cys Leu Pro Phe Pro Thr Gly Glu Thr Pro Ser Leu 
    690                 695                 700                 


Gly Phe Thr Val Thr Leu Val Leu Leu Asn Ser Leu Ala Phe Leu Leu 
705                 710                 715                 720 


Met Ala Val Ile Tyr Thr Lys Leu Tyr Cys Asn Leu Glu Lys Glu Asp 
                725                 730                 735     


Leu Ser Glu Asn Ser Gln Ser Ser Met Ile Lys His Val Ala Trp Leu 
            740                 745                 750         


Ile Phe Thr Asn Cys Ile Phe Phe Cys Pro Val Ala Phe Phe Ser Phe 
        755                 760                 765             


Ala Pro Leu Ile Thr Ala Ile Ser Ile Ser Pro Glu Ile Met Lys Ser 
    770                 775                 780                 


Val Thr Leu Ile Phe Phe Pro Leu Pro Ala Cys Leu Asn Pro Val Leu 
785                 790                 795                 800 


Tyr Val Phe Phe Asn Pro Lys Phe Lys Glu Asp Trp Lys Leu Leu Lys 
                805                 810                 815     


Arg Arg Val Thr Lys Lys Ser Gly Ser Val Ser Val Ser Ile Ser Ser 
            820                 825                 830         


Gln Gly Gly Cys Leu Glu Gln Asp Phe Tyr Tyr Asp Cys Gly Met Tyr 
        835                 840                 845             


Ser His Leu Gln Gly Asn Leu Thr Val Cys Asp Cys Cys Glu Ser Phe 
    850                 855                 860                 


Leu Leu Thr Lys Pro Val Ser Cys Lys His Leu Ile Lys Ser His Ser 
865                 870                 875                 880 


Cys Pro Ala Leu Ala Val Ala Ser Cys Gln Arg Pro Glu Gly Tyr Trp 
                885                 890                 895     


Ser Asp Cys Gly Thr Gln Ser Ala His Ser Asp Tyr Ala Asp Glu Glu 
            900                 905                 910         


Asp Ser Phe Val Ser Asp Ser Ser Asp Gln Val Gln Ala Cys Gly Arg 
        915                 920                 925             


Ala Cys Phe Tyr Gln Ser Arg Gly Phe Pro Leu Val Arg Tyr Ala Tyr 
    930                 935                 940                 


Asn Leu Pro Arg Val Lys Asp Ser Arg Asp Tyr Lys Asp Asp Asp Asp 
945                 950                 955                 960 


Lys Ala Gly Ala Asp Tyr Lys Asp Asp Asp Asp Lys Leu Asp Gly Gly 
                965                 970                 975     


Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Ala Gly Ala Tyr Pro Tyr Asp 
            980                 985                 990         


Val Pro Asp Tyr Ala 
        995         


<210>  4
<211>  635
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence hLGR4(ECD)-GPA33-FLAG insert in pVax1


<220>
<221>  SIGNAL
<222>  (1)..(24)

<220>
<221>  MISC_FEATURE
<222>  (543)..(627)
<223>  GPA33

<220>
<221>  MISC_FEATURE
<222>  (628)..(635)
<223>  FLAG tag

<400>  4

Met Pro Gly Pro Leu Gly Leu Leu Cys Phe Leu Ala Leu Gly Leu Leu 
1               5                   10                  15      


Gly Ser Ala Gly Pro Ser Gly Ala Ala Pro Pro Leu Cys Ala Ala Pro 
            20                  25                  30          


Cys Ser Cys Asp Gly Asp Arg Arg Val Asp Cys Ser Gly Lys Gly Leu 
        35                  40                  45              


Thr Ala Val Pro Glu Gly Leu Ser Ala Phe Thr Gln Ala Leu Asp Ile 
    50                  55                  60                  


Ser Met Asn Asn Ile Thr Gln Leu Pro Glu Asp Ala Phe Lys Asn Phe 
65                  70                  75                  80  


Pro Phe Leu Glu Glu Leu Gln Leu Ala Gly Asn Asp Leu Ser Phe Ile 
                85                  90                  95      


His Pro Lys Ala Leu Ser Gly Leu Lys Glu Leu Lys Val Leu Thr Leu 
            100                 105                 110         


Gln Asn Asn Gln Leu Lys Thr Val Pro Ser Glu Ala Ile Arg Gly Leu 
        115                 120                 125             


Ser Ala Leu Gln Ser Leu Arg Leu Asp Ala Asn His Ile Thr Ser Val 
    130                 135                 140                 


Pro Glu Asp Ser Phe Glu Gly Leu Val Gln Leu Arg His Leu Trp Leu 
145                 150                 155                 160 


Asp Asp Asn Ser Leu Thr Glu Val Pro Val His Pro Leu Ser Asn Leu 
                165                 170                 175     


Pro Thr Leu Gln Ala Leu Thr Leu Ala Leu Asn Lys Ile Ser Ser Ile 
            180                 185                 190         


Pro Asp Phe Ala Phe Thr Asn Leu Ser Ser Leu Val Val Leu His Leu 
        195                 200                 205             


His Asn Asn Lys Ile Arg Ser Leu Ser Gln His Cys Phe Asp Gly Leu 
    210                 215                 220                 


Asp Asn Leu Glu Thr Leu Asp Leu Asn Tyr Asn Asn Leu Gly Glu Phe 
225                 230                 235                 240 


Pro Gln Ala Ile Lys Ala Leu Pro Ser Leu Lys Glu Leu Gly Phe His 
                245                 250                 255     


Ser Asn Ser Ile Ser Val Ile Pro Asp Gly Ala Phe Asp Gly Asn Pro 
            260                 265                 270         


Leu Leu Arg Thr Ile His Leu Tyr Asp Asn Pro Leu Ser Phe Val Gly 
        275                 280                 285             


Asn Ser Ala Phe His Asn Leu Ser Asp Leu His Ser Leu Val Ile Arg 
    290                 295                 300                 


Gly Ala Ser Met Val Gln Gln Phe Pro Asn Leu Thr Gly Thr Val His 
305                 310                 315                 320 


Leu Glu Ser Leu Thr Leu Thr Gly Thr Lys Ile Ser Ser Ile Pro Asn 
                325                 330                 335     


Asn Leu Cys Gln Glu Gln Lys Met Leu Arg Thr Leu Asp Leu Ser Tyr 
            340                 345                 350         


Asn Asn Ile Arg Asp Leu Pro Ser Phe Asn Gly Cys His Ala Leu Glu 
        355                 360                 365             


Glu Ile Ser Leu Gln Arg Asn Gln Ile Tyr Gln Ile Lys Glu Gly Thr 
    370                 375                 380                 


Phe Gln Gly Leu Ile Ser Leu Arg Ile Leu Asp Leu Ser Arg Asn Leu 
385                 390                 395                 400 


Ile His Glu Ile His Ser Arg Ala Phe Ala Thr Leu Gly Pro Ile Thr 
                405                 410                 415     


Asn Leu Asp Val Ser Phe Asn Glu Leu Thr Ser Phe Pro Thr Glu Gly 
            420                 425                 430         


Leu Asn Gly Leu Asn Gln Leu Lys Leu Val Gly Asn Phe Lys Leu Lys 
        435                 440                 445             


Glu Ala Leu Ala Ala Lys Asp Phe Val Asn Leu Arg Ser Leu Ser Val 
    450                 455                 460                 


Pro Tyr Ala Tyr Gln Cys Cys Ala Phe Trp Gly Cys Asp Ser Tyr Ala 
465                 470                 475                 480 


Asn Leu Asn Thr Glu Asp Asn Ser Leu Gln Asp His Ser Val Ala Gln 
                485                 490                 495     


Glu Lys Gly Thr Ala Asp Ala Ala Asn Val Thr Ser Thr Leu Glu Asn 
            500                 505                 510         


Glu Glu His Ser Gln Ile Ile Ile His Cys Thr Pro Ser Thr Gly Ala 
        515                 520                 525             


Phe Lys Pro Cys Glu Tyr Leu Leu Gly Ser Trp Met Ile Arg Val Ala 
    530                 535                 540                 


Leu Tyr Val Gly Ile Ala Val Gly Val Val Ala Ala Leu Ile Ile Ile 
545                 550                 555                 560 


Gly Ile Ile Ile Tyr Cys Cys Cys Cys Arg Gly Lys Asp Asp Asn Thr 
                565                 570                 575     


Glu Asp Lys Glu Asp Ala Arg Pro Asn Arg Glu Ala Tyr Glu Glu Pro 
            580                 585                 590         


Pro Glu Gln Leu Arg Glu Leu Ser Arg Glu Arg Glu Glu Glu Asp Asp 
        595                 600                 605             


Tyr Arg Gln Glu Glu Gln Arg Ser Thr Gly Arg Glu Ser Pro Asp His 
    610                 615                 620                 


Leu Asp Gln Asp Tyr Lys Asp Asp Asp Asp Lys 
625                 630                 635 


<210>  5
<211>  953
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence full length hLGR5-FLAG-HA insert (


<220>
<221>  SIGNAL
<222>  (1)..(21)

<220>
<221>  MISC_FEATURE
<222>  (908)..(909)
<223>  linker

<220>
<221>  MISC_FEATURE
<222>  (910)..(918)
<223>  FLAG tag

<220>
<221>  MISC_FEATURE
<222>  (919)..(921)
<223>  linker

<220>
<221>  MISC_FEATURE
<222>  (922)..(929)
<223>  FLAG tag

<220>
<221>  MISC_FEATURE
<222>  (930)..(933)
<223>  linker

<220>
<221>  MISC_FEATURE
<222>  (934)..(942)
<223>  HA tag

<220>
<221>  MISC_FEATURE
<222>  (943)..(945)
<223>  linker

<220>
<221>  MISC_FEATURE
<222>  (946)..(953)
<223>  HA tag

<400>  5

Met Asp Thr Ser Arg Leu Gly Val Leu Leu Ser Leu Pro Val Leu Leu 
1               5                   10                  15      


Gln Leu Ala Thr Gly Gly Ser Ser Pro Arg Ser Gly Val Leu Leu Arg 
            20                  25                  30          


Gly Cys Pro Thr His Cys His Cys Glu Pro Asp Gly Arg Met Leu Leu 
        35                  40                  45              


Arg Val Asp Cys Ser Asp Leu Gly Leu Ser Glu Leu Pro Ser Asn Leu 
    50                  55                  60                  


Ser Val Phe Thr Ser Tyr Leu Asp Leu Ser Met Asn Asn Ile Ser Gln 
65                  70                  75                  80  


Leu Leu Pro Asn Pro Leu Pro Ser Leu Arg Phe Leu Glu Glu Leu Arg 
                85                  90                  95      


Leu Ala Gly Asn Ala Leu Thr Tyr Ile Pro Lys Gly Ala Phe Thr Gly 
            100                 105                 110         


Leu Tyr Ser Leu Lys Val Leu Met Leu Gln Asn Asn Gln Leu Arg His 
        115                 120                 125             


Val Pro Thr Glu Ala Leu Gln Asn Leu Arg Ser Leu Gln Ser Leu Arg 
    130                 135                 140                 


Leu Asp Ala Asn His Ile Ser Tyr Val Pro Pro Ser Cys Phe Ser Gly 
145                 150                 155                 160 


Leu His Ser Leu Arg His Leu Trp Leu Asp Asp Asn Ala Leu Thr Glu 
                165                 170                 175     


Ile Pro Val Gln Ala Phe Arg Ser Leu Ser Ala Leu Gln Ala Met Thr 
            180                 185                 190         


Leu Ala Leu Asn Lys Ile His His Ile Pro Asp Tyr Ala Phe Gly Asn 
        195                 200                 205             


Leu Ser Ser Leu Val Val Leu His Leu His Asn Asn Arg Ile His Ser 
    210                 215                 220                 


Leu Gly Lys Lys Cys Phe Asp Gly Leu His Ser Leu Glu Thr Leu Asp 
225                 230                 235                 240 


Leu Asn Tyr Asn Asn Leu Asp Glu Phe Pro Thr Ala Ile Arg Thr Leu 
                245                 250                 255     


Ser Asn Leu Lys Glu Leu Gly Phe His Ser Asn Asn Ile Arg Ser Ile 
            260                 265                 270         


Pro Glu Lys Ala Phe Val Gly Asn Pro Ser Leu Ile Thr Ile His Phe 
        275                 280                 285             


Tyr Asp Asn Pro Ile Gln Phe Val Gly Arg Ser Ala Phe Gln His Leu 
    290                 295                 300                 


Pro Glu Leu Arg Thr Leu Thr Leu Asn Gly Ala Ser Gln Ile Thr Glu 
305                 310                 315                 320 


Phe Pro Asp Leu Thr Gly Thr Ala Asn Leu Glu Ser Leu Thr Leu Thr 
                325                 330                 335     


Gly Ala Gln Ile Ser Ser Leu Pro Gln Thr Val Cys Asn Gln Leu Pro 
            340                 345                 350         


Asn Leu Gln Val Leu Asp Leu Ser Tyr Asn Leu Leu Glu Asp Leu Pro 
        355                 360                 365             


Ser Phe Ser Val Cys Gln Lys Leu Gln Lys Ile Asp Leu Arg His Asn 
    370                 375                 380                 


Glu Ile Tyr Glu Ile Lys Val Asp Thr Phe Gln Gln Leu Leu Ser Leu 
385                 390                 395                 400 


Arg Ser Leu Asn Leu Ala Trp Asn Lys Ile Ala Ile Ile His Pro Asn 
                405                 410                 415     


Ala Phe Ser Thr Leu Pro Ser Leu Ile Lys Leu Asp Leu Ser Ser Asn 
            420                 425                 430         


Leu Leu Ser Ser Phe Pro Ile Thr Gly Leu His Gly Leu Thr His Leu 
        435                 440                 445             


Lys Leu Thr Gly Asn His Ala Leu Gln Ser Leu Ile Ser Ser Glu Asn 
    450                 455                 460                 


Phe Pro Glu Leu Lys Val Ile Glu Met Pro Tyr Ala Tyr Gln Cys Cys 
465                 470                 475                 480 


Ala Phe Gly Val Cys Glu Asn Ala Tyr Lys Ile Ser Asn Gln Trp Asn 
                485                 490                 495     


Lys Gly Asp Asn Ser Ser Met Asp Asp Leu His Lys Lys Asp Ala Gly 
            500                 505                 510         


Met Phe Gln Ala Gln Asp Glu Arg Asp Leu Glu Asp Phe Leu Leu Asp 
        515                 520                 525             


Phe Glu Glu Asp Leu Lys Ala Leu His Ser Val Gln Cys Ser Pro Ser 
    530                 535                 540                 


Pro Gly Pro Phe Lys Pro Cys Glu His Leu Leu Asp Gly Trp Leu Ile 
545                 550                 555                 560 


Arg Ile Gly Val Trp Thr Ile Ala Val Leu Ala Leu Thr Cys Asn Ala 
                565                 570                 575     


Leu Val Thr Ser Thr Val Phe Arg Ser Pro Leu Tyr Ile Ser Pro Ile 
            580                 585                 590         


Lys Leu Leu Ile Gly Val Ile Ala Ala Val Asn Met Leu Thr Gly Val 
        595                 600                 605             


Ser Ser Ala Val Leu Ala Gly Val Asp Ala Phe Thr Phe Gly Ser Phe 
    610                 615                 620                 


Ala Arg His Gly Ala Trp Trp Glu Asn Gly Val Gly Cys His Val Ile 
625                 630                 635                 640 


Gly Phe Leu Ser Ile Phe Ala Ser Glu Ser Ser Val Phe Leu Leu Thr 
                645                 650                 655     


Leu Ala Ala Leu Glu Arg Gly Phe Ser Ala Lys Tyr Ser Ala Lys Phe 
            660                 665                 670         


Glu Thr Lys Ala Pro Phe Ser Ser Leu Lys Val Ile Ile Leu Leu Cys 
        675                 680                 685             


Ala Leu Leu Ala Leu Thr Met Ala Ala Val Pro Leu Leu Gly Gly Ser 
    690                 695                 700                 


Lys Tyr Gly Ala Ser Pro Leu Cys Leu Pro Leu Pro Phe Gly Glu Pro 
705                 710                 715                 720 


Ser Thr Met Gly Tyr Met Val Ala Leu Ile Leu Leu Asn Ser Leu Cys 
                725                 730                 735     


Phe Leu Met Met Thr Ile Ala Tyr Thr Lys Leu Tyr Cys Asn Leu Asp 
            740                 745                 750         


Lys Gly Asp Leu Glu Asn Ile Trp Asp Cys Ser Met Val Lys His Ile 
        755                 760                 765             


Ala Leu Leu Leu Phe Thr Asn Cys Ile Leu Asn Cys Pro Val Ala Phe 
    770                 775                 780                 


Leu Ser Phe Ser Ser Leu Ile Asn Leu Thr Phe Ile Ser Pro Glu Val 
785                 790                 795                 800 


Ile Lys Phe Ile Leu Leu Val Val Val Pro Leu Pro Ala Cys Leu Asn 
                805                 810                 815     


Pro Leu Leu Tyr Ile Leu Phe Asn Pro His Phe Lys Glu Asp Leu Val 
            820                 825                 830         


Ser Leu Arg Lys Gln Thr Tyr Val Trp Thr Arg Ser Lys His Pro Ser 
        835                 840                 845             


Leu Met Ser Ile Asn Ser Asp Asp Val Glu Lys Gln Ser Cys Asp Ser 
    850                 855                 860                 


Thr Gln Ala Leu Val Thr Phe Thr Ser Ser Ser Ile Thr Tyr Asp Leu 
865                 870                 875                 880 


Pro Pro Ser Ser Val Pro Ser Pro Ala Tyr Pro Val Thr Glu Ser Cys 
                885                 890                 895     


His Leu Ser Ser Val Ala Phe Val Pro Cys Leu Ala Arg Asp Tyr Lys 
            900                 905                 910         


Asp Asp Asp Asp Lys Ala Gly Ala Asp Tyr Lys Asp Asp Asp Asp Lys 
        915                 920                 925             


Leu Asp Gly Gly Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Ala Gly Ala 
    930                 935                 940                 


Tyr Pro Tyr Asp Val Pro Asp Tyr Ala 
945                 950             


<210>  6
<211>  654
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence hLGR5(ECD)-GPA33(TM)-FLAG insert in pVax1


<220>
<221>  SIGNAL
<222>  (1)..(21)

<220>
<221>  MISC_FEATURE
<222>  (563)..(646)
<223>  GPA33

<220>
<221>  MISC_FEATURE
<222>  (647)..(654)
<223>  FLAG tag

<400>  6

Met Asp Thr Ser Arg Leu Gly Val Leu Leu Ser Leu Pro Val Leu Leu 
1               5                   10                  15      


Gln Leu Ala Thr Gly Gly Ser Ser Pro Arg Ser Gly Val Leu Leu Arg 
            20                  25                  30          


Gly Cys Pro Thr His Cys His Cys Glu Pro Asp Gly Arg Met Leu Leu 
        35                  40                  45              


Arg Val Asp Cys Ser Asp Leu Gly Leu Ser Glu Leu Pro Ser Asn Leu 
    50                  55                  60                  


Ser Val Phe Thr Ser Tyr Leu Asp Leu Ser Met Asn Asn Ile Ser Gln 
65                  70                  75                  80  


Leu Leu Pro Asn Pro Leu Pro Ser Leu Arg Phe Leu Glu Glu Leu Arg 
                85                  90                  95      


Leu Ala Gly Asn Ala Leu Thr Tyr Ile Pro Lys Gly Ala Phe Thr Gly 
            100                 105                 110         


Leu Tyr Ser Leu Lys Val Leu Met Leu Gln Asn Asn Gln Leu Arg His 
        115                 120                 125             


Val Pro Thr Glu Ala Leu Gln Asn Leu Arg Ser Leu Gln Ser Leu Arg 
    130                 135                 140                 


Leu Asp Ala Asn His Ile Ser Tyr Val Pro Pro Ser Cys Phe Ser Gly 
145                 150                 155                 160 


Leu His Ser Leu Arg His Leu Trp Leu Asp Asp Asn Ala Leu Thr Glu 
                165                 170                 175     


Ile Pro Val Gln Ala Phe Arg Ser Leu Ser Ala Leu Gln Ala Met Thr 
            180                 185                 190         


Leu Ala Leu Asn Lys Ile His His Ile Pro Asp Tyr Ala Phe Gly Asn 
        195                 200                 205             


Leu Ser Ser Leu Val Val Leu His Leu His Asn Asn Arg Ile His Ser 
    210                 215                 220                 


Leu Gly Lys Lys Cys Phe Asp Gly Leu His Ser Leu Glu Thr Leu Asp 
225                 230                 235                 240 


Leu Asn Tyr Asn Asn Leu Asp Glu Phe Pro Thr Ala Ile Arg Thr Leu 
                245                 250                 255     


Ser Asn Leu Lys Glu Leu Gly Phe His Ser Asn Asn Ile Arg Ser Ile 
            260                 265                 270         


Pro Glu Lys Ala Phe Val Gly Asn Pro Ser Leu Ile Thr Ile His Phe 
        275                 280                 285             


Tyr Asp Asn Pro Ile Gln Phe Val Gly Arg Ser Ala Phe Gln His Leu 
    290                 295                 300                 


Pro Glu Leu Arg Thr Leu Thr Leu Asn Gly Ala Ser Gln Ile Thr Glu 
305                 310                 315                 320 


Phe Pro Asp Leu Thr Gly Thr Ala Asn Leu Glu Ser Leu Thr Leu Thr 
                325                 330                 335     


Gly Ala Gln Ile Ser Ser Leu Pro Gln Thr Val Cys Asn Gln Leu Pro 
            340                 345                 350         


Asn Leu Gln Val Leu Asp Leu Ser Tyr Asn Leu Leu Glu Asp Leu Pro 
        355                 360                 365             


Ser Phe Ser Val Cys Gln Lys Leu Gln Lys Ile Asp Leu Arg His Asn 
    370                 375                 380                 


Glu Ile Tyr Glu Ile Lys Val Asp Thr Phe Gln Gln Leu Leu Ser Leu 
385                 390                 395                 400 


Arg Ser Leu Asn Leu Ala Trp Asn Lys Ile Ala Ile Ile His Pro Asn 
                405                 410                 415     


Ala Phe Ser Thr Leu Pro Ser Leu Ile Lys Leu Asp Leu Ser Ser Asn 
            420                 425                 430         


Leu Leu Ser Ser Phe Pro Ile Thr Gly Leu His Gly Leu Thr His Leu 
        435                 440                 445             


Lys Leu Thr Gly Asn His Ala Leu Gln Ser Leu Ile Ser Ser Glu Asn 
    450                 455                 460                 


Phe Pro Glu Leu Lys Val Ile Glu Met Pro Tyr Ala Tyr Gln Cys Cys 
465                 470                 475                 480 


Ala Phe Gly Val Cys Glu Asn Ala Tyr Lys Ile Ser Asn Gln Trp Asn 
                485                 490                 495     


Lys Gly Asp Asn Ser Ser Met Asp Asp Leu His Lys Lys Asp Ala Gly 
            500                 505                 510         


Met Phe Gln Ala Gln Asp Glu Arg Asp Leu Glu Asp Phe Leu Leu Asp 
        515                 520                 525             


Phe Glu Glu Asp Leu Lys Ala Leu His Ser Val Gln Cys Ser Pro Ser 
    530                 535                 540                 


Pro Gly Pro Phe Lys Pro Cys Glu His Leu Leu Asp Gly Trp Leu Ile 
545                 550                 555                 560 


Arg Val Ala Leu Tyr Val Gly Ile Ala Val Gly Val Val Ala Ala Leu 
                565                 570                 575     


Ile Ile Ile Gly Ile Ile Ile Tyr Cys Cys Cys Cys Arg Gly Lys Asp 
            580                 585                 590         


Asp Asn Thr Glu Asp Lys Glu Asp Ala Arg Pro Asn Arg Glu Ala Tyr 
        595                 600                 605             


Glu Glu Pro Pro Glu Gln Leu Arg Glu Leu Ser Arg Glu Arg Glu Glu 
    610                 615                 620                 


Glu Asp Asp Tyr Arg Gln Glu Glu Gln Arg Ser Thr Gly Arg Glu Ser 
625                 630                 635                 640 


Pro Asp His Leu Asp Gln Asp Tyr Lys Asp Asp Asp Asp Lys 
                645                 650                 


<210>  7
<211>  936
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence full length mouse (m)Lgr5-Myc-HIS insert in 
       pEF1_Myc/His


<220>
<221>  SIGNAL
<222>  (1)..(21)

<220>
<221>  MISC_FEATURE
<222>  (908)..(915)
<223>  linker

<220>
<221>  MISC_FEATURE
<222>  (916)..(925)
<223>  cMyc-tag

<220>
<221>  MISC_FEATURE
<222>  (926)..(930)
<223>  linker

<220>
<221>  MISC_FEATURE
<222>  (931)..(936)
<223>  His tag

<400>  7

Met Asp Thr Ser Cys Val His Met Leu Leu Ser Leu Leu Ala Leu Leu 
1               5                   10                  15      


Gln Leu Val Ala Ala Gly Ser Ser Pro Gly Pro Asp Ala Ile Pro Arg 
            20                  25                  30          


Gly Cys Pro Ser His Cys His Cys Glu Leu Asp Gly Arg Met Leu Leu 
        35                  40                  45              


Arg Val Asp Cys Ser Asp Leu Gly Leu Ser Glu Leu Pro Ser Asn Leu 
    50                  55                  60                  


Ser Val Phe Thr Ser Tyr Leu Asp Leu Ser Met Asn Asn Ile Ser Gln 
65                  70                  75                  80  


Leu Pro Ala Ser Leu Leu His Arg Leu Cys Phe Leu Glu Glu Leu Arg 
                85                  90                  95      


Leu Ala Gly Asn Ala Leu Thr His Ile Pro Lys Gly Ala Phe Thr Gly 
            100                 105                 110         


Leu His Ser Leu Lys Val Leu Met Leu Gln Asn Asn Gln Leu Arg Gln 
        115                 120                 125             


Val Pro Glu Glu Ala Leu Gln Asn Leu Arg Ser Leu Gln Ser Leu Arg 
    130                 135                 140                 


Leu Asp Ala Asn His Ile Ser Tyr Val Pro Pro Ser Cys Phe Ser Gly 
145                 150                 155                 160 


Leu His Ser Leu Arg His Leu Trp Leu Asp Asp Asn Ala Leu Thr Asp 
                165                 170                 175     


Val Pro Val Gln Ala Phe Arg Ser Leu Ser Ala Leu Gln Ala Met Thr 
            180                 185                 190         


Leu Ala Leu Asn Lys Ile His His Ile Ala Asp Tyr Ala Phe Gly Asn 
        195                 200                 205             


Leu Ser Ser Leu Val Val Leu His Leu His Asn Asn Arg Ile His Ser 
    210                 215                 220                 


Leu Gly Lys Lys Cys Phe Asp Gly Leu His Ser Leu Glu Thr Leu Asp 
225                 230                 235                 240 


Leu Asn Tyr Asn Asn Leu Asp Glu Phe Pro Thr Ala Ile Lys Thr Leu 
                245                 250                 255     


Ser Asn Leu Lys Glu Leu Gly Phe His Ser Asn Asn Ile Arg Ser Ile 
            260                 265                 270         


Pro Glu Arg Ala Phe Val Gly Asn Pro Ser Leu Ile Thr Ile His Phe 
        275                 280                 285             


Tyr Asp Asn Pro Ile Gln Phe Val Gly Val Ser Ala Phe Gln His Leu 
    290                 295                 300                 


Pro Glu Leu Arg Thr Leu Thr Leu Asn Gly Ala Ser His Ile Thr Glu 
305                 310                 315                 320 


Phe Pro His Leu Thr Gly Thr Ala Thr Leu Glu Ser Leu Thr Leu Thr 
                325                 330                 335     


Gly Ala Lys Ile Ser Ser Leu Pro Gln Ala Val Cys Asp Gln Leu Pro 
            340                 345                 350         


Asn Leu Gln Val Leu Asp Leu Ser Tyr Asn Leu Leu Glu Asp Leu Pro 
        355                 360                 365             


Ser Leu Ser Gly Cys Gln Lys Leu Gln Lys Ile Asp Leu Arg His Asn 
    370                 375                 380                 


Glu Ile Tyr Glu Ile Lys Gly Ser Thr Phe Gln Gln Leu Phe Asn Leu 
385                 390                 395                 400 


Arg Ser Leu Asn Leu Ala Trp Asn Lys Ile Ala Ile Ile His Pro Asn 
                405                 410                 415     


Ala Phe Ser Thr Leu Pro Ser Leu Ile Lys Leu Asp Leu Ser Ser Asn 
            420                 425                 430         


Leu Leu Ser Ser Phe Pro Val Thr Gly Leu His Gly Leu Thr His Leu 
        435                 440                 445             


Lys Leu Thr Gly Asn Arg Ala Leu Gln Ser Leu Ile Pro Ser Ala Asn 
    450                 455                 460                 


Phe Pro Glu Leu Lys Ile Ile Glu Met Pro Ser Ala Tyr Gln Cys Cys 
465                 470                 475                 480 


Ala Phe Gly Gly Cys Glu Asn Val Tyr Lys Ile Ser Asn Gln Trp Asn 
                485                 490                 495     


Lys Asp Asp Gly Asn Ser Val Asp Asp Leu His Lys Lys Asp Ala Gly 
            500                 505                 510         


Leu Phe Gln Val Gln Asp Glu Arg Asp Leu Glu Asp Phe Leu Leu Asp 
        515                 520                 525             


Phe Glu Glu Asp Leu Lys Ala Leu His Ser Val Gln Cys Ser Pro Ser 
    530                 535                 540                 


Pro Gly Pro Phe Lys Pro Cys Glu His Leu Phe Gly Ser Trp Leu Ile 
545                 550                 555                 560 


Arg Ile Gly Val Trp Thr Thr Ala Val Leu Ala Leu Ser Cys Asn Ala 
                565                 570                 575     


Leu Val Ala Leu Thr Val Phe Arg Thr Pro Leu Tyr Ile Ser Ser Ile 
            580                 585                 590         


Lys Leu Leu Ile Gly Val Ile Ala Val Val Asp Ile Leu Met Gly Val 
        595                 600                 605             


Ser Ser Ala Val Leu Ala Ala Val Asp Ala Phe Thr Phe Gly Arg Phe 
    610                 615                 620                 


Ala Gln His Gly Ala Trp Trp Glu Asp Gly Ile Gly Cys Gln Ile Val 
625                 630                 635                 640 


Gly Phe Leu Ser Ile Phe Ala Ser Glu Ser Ser Ile Phe Leu Leu Thr 
                645                 650                 655     


Leu Ala Ala Leu Glu Arg Gly Phe Ser Val Lys Cys Ser Ser Lys Phe 
            660                 665                 670         


Glu Val Lys Ala Pro Leu Phe Ser Leu Arg Ala Ile Val Leu Leu Cys 
        675                 680                 685             


Val Leu Leu Ala Leu Thr Ile Ala Thr Ile Pro Leu Leu Gly Gly Ser 
    690                 695                 700                 


Lys Tyr Asn Ala Ser Pro Leu Cys Leu Pro Leu Pro Phe Gly Glu Pro 
705                 710                 715                 720 


Ser Thr Thr Gly Tyr Met Val Ala Leu Val Leu Leu Asn Ser Leu Cys 
                725                 730                 735     


Phe Leu Ile Met Thr Ile Ala Tyr Thr Lys Leu Tyr Cys Ser Leu Glu 
            740                 745                 750         


Lys Gly Glu Leu Glu Asn Leu Trp Asp Cys Ser Met Val Lys His Ile 
        755                 760                 765             


Ala Leu Leu Leu Phe Ala Asn Cys Ile Leu Tyr Cys Pro Val Ala Phe 
    770                 775                 780                 


Leu Ser Phe Ser Ser Leu Leu Asn Leu Thr Phe Ile Ser Pro Asp Val 
785                 790                 795                 800 


Ile Lys Phe Ile Leu Leu Val Ile Val Pro Leu Pro Ser Cys Leu Asn 
                805                 810                 815     


Pro Leu Leu Tyr Ile Val Phe Asn Pro His Phe Lys Glu Asp Met Gly 
            820                 825                 830         


Ser Leu Gly Lys His Thr Arg Phe Trp Met Arg Ser Lys His Ala Ser 
        835                 840                 845             


Leu Leu Ser Ile Asn Ser Asp Asp Val Glu Lys Arg Ser Cys Glu Ser 
    850                 855                 860                 


Thr Gln Ala Leu Val Ser Phe Thr His Ala Ser Ile Ala Tyr Asp Leu 
865                 870                 875                 880 


Pro Ser Thr Ser Gly Ala Ser Pro Ala Tyr Pro Met Thr Glu Ser Cys 
                885                 890                 895     


His Leu Ser Ser Val Ala Phe Val Pro Cys Leu Ala Ala Ala Arg Gly 
            900                 905                 910         


His Pro Phe Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Asn Met His 
        915                 920                 925             


Thr Gly His His His His His His 
    930                 935     


<210>  8
<211>  281
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human ZNRF3(ECD) in pDisplay


<220>
<221>  SIGNAL
<222>  (1)..(55)

<220>
<221>  MISC_FEATURE
<222>  (222)..(231)
<223>  cMyc-tag

<220>
<221>  MISC_FEATURE
<222>  (232)..(281)
<223>  PDGFR

<400>  8

Met Arg Pro Arg Ser Gly Gly Arg Pro Gly Ala Thr Gly Arg Arg Arg 
1               5                   10                  15      


Arg Arg Leu Arg Arg Arg Pro Arg Gly Leu Arg Cys Ser Arg Leu Pro 
            20                  25                  30          


Pro Pro Pro Pro Leu Pro Leu Leu Leu Gly Leu Leu Leu Ala Ala Ala 
        35                  40                  45              


Gly Pro Gly Ala Ala Arg Ala Lys Glu Thr Ala Phe Val Glu Val Val 
    50                  55                  60                  


Leu Phe Glu Ser Ser Pro Ser Gly Asp Tyr Thr Thr Tyr Thr Thr Gly 
65                  70                  75                  80  


Leu Thr Gly Arg Phe Ser Arg Ala Gly Ala Thr Leu Ser Ala Glu Gly 
                85                  90                  95      


Glu Ile Val Gln Met His Pro Leu Gly Leu Cys Asn Asn Asn Asp Glu 
            100                 105                 110         


Glu Asp Leu Tyr Glu Tyr Gly Trp Val Gly Val Val Lys Leu Glu Gln 
        115                 120                 125             


Pro Glu Leu Asp Pro Lys Pro Cys Leu Thr Val Leu Gly Lys Ala Lys 
    130                 135                 140                 


Arg Ala Val Gln Arg Gly Ala Thr Ala Val Ile Phe Asp Val Ser Glu 
145                 150                 155                 160 


Asn Pro Glu Ala Ile Asp Gln Leu Asn Gln Gly Ser Glu Asp Pro Leu 
                165                 170                 175     


Lys Arg Pro Val Val Tyr Val Lys Gly Ala Asp Ala Ile Lys Leu Met 
            180                 185                 190         


Asn Ile Val Asn Lys Gln Lys Val Ala Arg Ala Arg Ile Gln His Arg 
        195                 200                 205             


Pro Pro Arg Gln Pro Thr Glu Tyr Phe Asp Met Val Asp Glu Gln Lys 
    210                 215                 220                 


Leu Ile Ser Glu Glu Asp Leu Asn Ala Val Gly Gln Asp Thr Gln Glu 
225                 230                 235                 240 


Val Ile Val Val Pro His Ser Leu Pro Phe Lys Val Val Val Ile Ser 
                245                 250                 255     


Ala Ile Leu Ala Leu Val Val Leu Thr Ile Ile Ser Leu Ile Ile Leu 
            260                 265                 270         


Ile Met Leu Trp Gln Lys Lys Pro Arg 
        275                 280     


<210>  9
<211>  256
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human ZNRF3 truncation mutant


<220>
<221>  SIGNAL
<222>  (1)..(55)

<220>
<221>  MISC_FEATURE
<222>  (218)..(232)
<223>  predicted TM region

<220>
<221>  MISC_FEATURE
<222>  (233)..(256)
<223>  intracellular tail

<400>  9

Met Arg Pro Arg Ser Gly Gly Arg Pro Gly Ala Thr Gly Arg Arg Arg 
1               5                   10                  15      


Arg Arg Leu Arg Arg Arg Pro Arg Gly Leu Arg Cys Ser Arg Leu Pro 
            20                  25                  30          


Pro Pro Pro Pro Leu Pro Leu Leu Leu Gly Leu Leu Leu Ala Ala Ala 
        35                  40                  45              


Gly Pro Gly Ala Ala Arg Ala Lys Glu Thr Ala Phe Val Glu Val Val 
    50                  55                  60                  


Leu Phe Glu Ser Ser Pro Ser Gly Asp Tyr Thr Thr Tyr Thr Thr Gly 
65                  70                  75                  80  


Leu Thr Gly Arg Phe Ser Arg Ala Gly Ala Thr Leu Ser Ala Glu Gly 
                85                  90                  95      


Glu Ile Val Gln Met His Pro Leu Gly Leu Cys Asn Asn Asn Asp Glu 
            100                 105                 110         


Glu Asp Leu Tyr Glu Tyr Gly Trp Val Gly Val Val Lys Leu Glu Gln 
        115                 120                 125             


Pro Glu Leu Asp Pro Lys Pro Cys Leu Thr Val Leu Gly Lys Ala Lys 
    130                 135                 140                 


Arg Ala Val Gln Arg Gly Ala Thr Ala Val Ile Phe Asp Val Ser Glu 
145                 150                 155                 160 


Asn Pro Glu Ala Ile Asp Gln Leu Asn Gln Gly Ser Glu Asp Pro Leu 
                165                 170                 175     


Lys Arg Pro Val Val Tyr Val Lys Gly Ala Asp Ala Ile Lys Leu Met 
            180                 185                 190         


Asn Ile Val Asn Lys Gln Lys Val Ala Arg Ala Arg Ile Gln His Arg 
        195                 200                 205             


Pro Pro Arg Gln Pro Thr Glu Tyr Phe Asp Met Gly Ile Phe Leu Ala 
    210                 215                 220                 


Phe Phe Val Val Val Ser Leu Val Cys Leu Ile Leu Leu Val Lys Ile 
225                 230                 235                 240 


Lys Leu Lys Gln Arg Arg Ser Gln Asn Ser Met Asn Arg Pro Ala Val 
                245                 250                 255     


<210>  10
<211>  164
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse ZNRF3 ECD-His in pUPE


<220>
<221>  MISC_FEATURE
<222>  (1)..(2)
<223>  amino acids encoded by cloning sites

<220>
<221>  MISC_FEATURE
<222>  (155)..(157)
<223>  amino acids encoded by cloning sites

<220>
<221>  MISC_FEATURE
<222>  (158)..(164)
<223>  His tag

<400>  10

Gly Ser Lys Glu Thr Ala Phe Val Glu Val Val Leu Phe Glu Ser Ser 
1               5                   10                  15      


Pro Ser Gly Asp Tyr Thr Thr His Thr Thr Gly Leu Thr Gly Arg Phe 
            20                  25                  30          


Ser Arg Ala Gly Ala Met Leu Ser Ala Glu Gly Glu Ile Val Gln Met 
        35                  40                  45              


His Pro Leu Gly Leu Cys Asn Asn Asn Asp Glu Glu Asp Leu Tyr Glu 
    50                  55                  60                  


Tyr Gly Trp Val Gly Val Val Lys Leu Glu Gln Pro Glu Leu Asp Pro 
65                  70                  75                  80  


Lys Pro Cys Leu Thr Val Leu Gly Lys Ala Lys Arg Ala Val Gln Arg 
                85                  90                  95      


Gly Ala Thr Ala Val Ile Phe Asp Val Ser Glu Asn Pro Glu Ala Ile 
            100                 105                 110         


Asp Gln Leu Asn Gln Gly Ser Glu Asp Pro Leu Lys Arg Pro Val Val 
        115                 120                 125             


Tyr Val Lys Gly Ala Asp Ala Ile Lys Leu Met Asn Ile Val Asn Lys 
    130                 135                 140                 


Gln Lys Val Ala Arg Ala Arg Ile Gln His Leu Ala Ala Ala His His 
145                 150                 155                 160 


His His His His 
                


<210>  11
<211>  278
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse (m)ZNRF3 sequence in pDisplay


<220>
<221>  SIGNAL
<222>  (1)..(52)

<220>
<221>  MISC_FEATURE
<222>  (217)..(218)
<223>  amino acids that are encoded by cloning sites

<220>
<221>  MISC_FEATURE
<222>  (219)..(228)
<223>  cMyc-tag

<220>
<221>  MISC_FEATURE
<222>  (229)..(278)
<223>  PDGFR

<400>  11

Met Arg Pro Arg Ser Gly Gly Arg Pro Gly Ala Pro Gly Arg Arg Arg 
1               5                   10                  15      


Arg Arg Leu Arg Arg Gly Pro Arg Gly Arg Arg Leu Pro Pro Pro Pro 
            20                  25                  30          


Pro Leu Pro Leu Leu Leu Gly Leu Leu Leu Ala Ala Ala Gly Pro Gly 
        35                  40                  45              


Ala Ala Arg Ala Lys Glu Thr Ala Phe Val Glu Val Val Leu Phe Glu 
    50                  55                  60                  


Ser Ser Pro Ser Gly Asp Tyr Thr Thr His Thr Thr Gly Leu Thr Gly 
65                  70                  75                  80  


Arg Phe Ser Arg Ala Gly Ala Met Leu Ser Ala Glu Gly Glu Ile Val 
                85                  90                  95      


Gln Met His Pro Leu Gly Leu Cys Asn Asn Asn Asp Glu Glu Asp Leu 
            100                 105                 110         


Tyr Glu Tyr Gly Trp Val Gly Val Val Lys Leu Glu Gln Pro Glu Leu 
        115                 120                 125             


Asp Pro Lys Pro Cys Leu Thr Val Leu Gly Lys Ala Lys Arg Ala Val 
    130                 135                 140                 


Gln Arg Gly Ala Thr Ala Val Ile Phe Asp Val Ser Glu Asn Pro Glu 
145                 150                 155                 160 


Ala Ile Asp Gln Leu Asn Gln Gly Ser Glu Asp Pro Leu Lys Arg Pro 
                165                 170                 175     


Val Val Tyr Val Lys Gly Ala Asp Ala Ile Lys Leu Met Asn Ile Val 
            180                 185                 190         


Asn Lys Gln Lys Val Ala Arg Ala Arg Ile Gln His Leu Pro Pro Arg 
        195                 200                 205             


Gln Pro Thr Glu Tyr Phe Asp Met Val Asp Glu Gln Lys Leu Ile Ser 
    210                 215                 220                 


Glu Glu Asp Leu Asn Ala Val Gly Gln Asp Thr Gln Glu Val Ile Val 
225                 230                 235                 240 


Val Pro His Ser Leu Pro Phe Lys Val Val Val Ile Ser Ala Ile Leu 
                245                 250                 255     


Ala Leu Val Val Leu Thr Ile Ile Ser Leu Ile Ile Leu Ile Met Leu 
            260                 265                 270         


Trp Gln Lys Lys Pro Arg 
        275             


<210>  12
<211>  261
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human RNF43 in pDisplay


<220>
<221>  SIGNAL
<222>  (1)..(42)

<220>
<221>  MISC_FEATURE
<222>  (200)..(201)
<223>  amino acids encoded by cloning sites

<220>
<221>  MISC_FEATURE
<222>  (202)..(211)
<223>  cMyc-tag

<220>
<221>  MISC_FEATURE
<222>  (212)..(261)
<223>  PDGFR

<400>  12

Met Ser Gly Gly His Gln Leu Gln Leu Ala Ala Leu Trp Pro Trp Leu 
1               5                   10                  15      


Leu Met Ala Thr Leu Gln Ala Gly Phe Gly Arg Thr Gly Leu Val Leu 
            20                  25                  30          


Ala Ala Ala Val Glu Ser Glu Arg Ser Ala Glu Gln Lys Ala Ile Ile 
        35                  40                  45              


Arg Val Ile Pro Leu Lys Met Asp Pro Thr Gly Lys Leu Asn Leu Thr 
    50                  55                  60                  


Leu Glu Gly Val Phe Ala Gly Val Ala Glu Ile Thr Pro Ala Glu Gly 
65                  70                  75                  80  


Lys Leu Met Gln Ser His Pro Leu Tyr Leu Cys Asn Ala Ser Asp Asp 
                85                  90                  95      


Asp Asn Leu Glu Pro Gly Phe Ile Ser Ile Val Lys Leu Glu Ser Pro 
            100                 105                 110         


Arg Arg Ala Pro Arg Pro Cys Leu Ser Leu Ala Ser Lys Ala Arg Met 
        115                 120                 125             


Ala Gly Glu Arg Gly Ala Ser Ala Val Leu Phe Asp Ile Thr Glu Asp 
    130                 135                 140                 


Arg Ala Ala Ala Glu Gln Leu Gln Gln Pro Leu Gly Leu Thr Trp Pro 
145                 150                 155                 160 


Val Val Leu Ile Trp Gly Asn Asp Ala Glu Lys Leu Met Glu Phe Val 
                165                 170                 175     


Tyr Lys Asn Gln Lys Ala His Val Arg Ile Glu Leu Lys Glu Pro Pro 
            180                 185                 190         


Ala Trp Pro Asp Tyr Asp Val Val Asp Glu Gln Lys Leu Ile Ser Glu 
        195                 200                 205             


Glu Asp Leu Asn Ala Val Gly Gln Asp Thr Gln Glu Val Ile Val Val 
    210                 215                 220                 


Pro His Ser Leu Pro Phe Lys Val Val Val Ile Ser Ala Ile Leu Ala 
225                 230                 235                 240 


Leu Val Val Leu Thr Ile Ile Ser Leu Ile Ile Leu Ile Met Leu Trp 
                245                 250                 255     


Gln Lys Lys Pro Arg 
            260     


<210>  13
<211>  261
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse RNF43 in pDisplay


<220>
<221>  MISC_FEATURE
<222>  (200)..(201)
<223>  amino acids  encoded by cloning site

<220>
<221>  MISC_FEATURE
<222>  (202)..(211)
<223>  cMyc-tag

<220>
<221>  MISC_FEATURE
<222>  (212)..(261)
<223>  PDGFR

<400>  13

Met Ser Gly Gly His Gln Leu Gln Leu Ala Val Leu Trp Pro Trp Leu 
1               5                   10                  15      


Leu Met Ala Thr Leu His Ala Gly Phe Gly His Thr Gly Arg Val Leu 
            20                  25                  30          


Ala Ala Ala Val Glu Ser Glu Arg Ser Ala Glu Gln Lys Ala Val Ile 
        35                  40                  45              


Arg Val Ile Pro Leu Lys Met Asp Pro Thr Gly Lys Leu Asn Leu Thr 
    50                  55                  60                  


Leu Glu Gly Val Phe Ala Gly Val Ala Glu Val Thr Pro Ala Glu Gly 
65                  70                  75                  80  


Lys Leu Met Gln Ser His Pro Leu Tyr Leu Cys Asn Ala Ser Asp Asp 
                85                  90                  95      


Asp Asn Leu Glu Pro Gly Phe Ile Ser Ile Val Lys Leu Glu Ser Pro 
            100                 105                 110         


Arg Arg Ala Pro Arg Pro Cys Leu Ser Leu Ala Ser Lys Ala Arg Met 
        115                 120                 125             


Ala Gly Glu Arg Gly Ala Asn Ala Val Leu Phe Asp Ile Thr Glu Asp 
    130                 135                 140                 


Arg Ser Ala Ala Glu Gln Leu Gln Gln Pro Leu Gly Leu Thr Lys Pro 
145                 150                 155                 160 


Val Val Leu Ile Trp Gly Ser Asp Ala Ala Lys Leu Met Glu Phe Val 
                165                 170                 175     


Tyr Lys Asn Arg Lys Ala Tyr Val Trp Ile Glu Leu Lys Glu Pro Pro 
            180                 185                 190         


Ala Gly Ala Asn Tyr Asp Val Val Asp Glu Gln Lys Leu Ile Ser Glu 
        195                 200                 205             


Glu Asp Leu Asn Ala Val Gly Gln Asp Thr Gln Glu Val Ile Val Val 
    210                 215                 220                 


Pro His Ser Leu Pro Phe Lys Val Val Val Ile Ser Ala Ile Leu Ala 
225                 230                 235                 240 


Leu Val Val Leu Thr Ile Ile Ser Leu Ile Ile Leu Ile Met Leu Trp 
                245                 250                 255     


Gln Lys Lys Pro Arg 
            260     


<210>  14
<211>  43
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  14
ccagcaggat ccgccgccac catggacacc tcccggctcg gtg                         43


<210>  15
<211>  38
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  15
ccagcagcgg ccgcttagag acatgggaca aatgccac                               38


<210>  16
<211>  907
<212>  PRT
<213>  Macaca fascicularis


<220>
<221>  SIGNAL
<222>  (1)..(21)

<400>  16

Met Asp Thr Ser Arg Leu Gly Val Leu Leu Ser Leu Pro Val Leu Leu 
1               5                   10                  15      


Gln Leu Ala Ala Gly Ser Ser Ser Pro Arg Ser Gly Ala Leu Leu Arg 
            20                  25                  30          


Gly Cys Pro Thr His Cys His Cys Glu Pro Asp Gly Arg Met Leu Leu 
        35                  40                  45              


Arg Val Asp Cys Ser Asp Leu Gly Leu Ser Glu Leu Pro Ser Asn Leu 
    50                  55                  60                  


Ser Val Phe Thr Ser Tyr Leu Asp Leu Ser Met Asn Asn Ile Ser Gln 
65                  70                  75                  80  


Leu Leu Pro Asn Pro Leu Pro Ser Leu Arg Phe Leu Glu Glu Leu Arg 
                85                  90                  95      


Leu Ala Gly Asn Ala Leu Thr Tyr Ile Pro Lys Gly Ala Phe Thr Gly 
            100                 105                 110         


Leu Tyr Ser Leu Lys Val Leu Met Leu Gln Asn Asn Gln Leu Arg Gln 
        115                 120                 125             


Val Pro Thr Glu Ala Leu Gln Asn Leu Arg Ser Leu Gln Ser Leu Arg 
    130                 135                 140                 


Leu Asp Ala Asn His Ile Ser Tyr Val Pro Pro Ser Cys Phe Ser Gly 
145                 150                 155                 160 


Leu His Ser Leu Arg His Leu Trp Leu Asp Asp Asn Ala Leu Thr Glu 
                165                 170                 175     


Ile Pro Val Gln Ala Phe Arg Ser Leu Ser Ala Leu Gln Ala Met Thr 
            180                 185                 190         


Leu Ala Leu Asn Lys Ile His His Ile Pro Asp Tyr Ala Phe Gly Asn 
        195                 200                 205             


Leu Ser Ser Leu Val Val Leu His Leu His Asn Asn Arg Ile His Ser 
    210                 215                 220                 


Leu Gly Lys Lys Cys Phe Asp Gly Leu His Ser Leu Glu Thr Leu Asp 
225                 230                 235                 240 


Leu Asn Tyr Asn Asn Leu Asp Glu Phe Pro Thr Ala Ile Arg Thr Leu 
                245                 250                 255     


Ser Asn Leu Lys Glu Leu Gly Phe His Ser Asn Asn Ile Arg Ser Ile 
            260                 265                 270         


Pro Glu Lys Ala Phe Val Gly Asn Pro Ser Leu Ile Thr Ile His Phe 
        275                 280                 285             


Tyr Asp Asn Pro Ile Gln Phe Val Gly Arg Ser Ala Phe Gln His Leu 
    290                 295                 300                 


Pro Glu Leu Arg Thr Leu Thr Leu Asn Gly Ala Ser Gln Ile Thr Glu 
305                 310                 315                 320 


Phe Pro Asp Leu Thr Gly Thr Ala Asn Leu Glu Ser Leu Thr Leu Thr 
                325                 330                 335     


Gly Ala Gln Ile Ser Ser Leu Pro Gln Thr Val Cys Asn Gln Leu Pro 
            340                 345                 350         


Asn Leu Gln Val Leu Asp Leu Ser Tyr Asn Leu Leu Glu Asp Leu Pro 
        355                 360                 365             


Ser Phe Ser Val Cys Gln Lys Leu Gln Lys Ile Asp Leu Arg His Asn 
    370                 375                 380                 


Glu Ile Tyr Glu Ile Lys Val Asp Thr Phe Gln Gln Leu Leu Ser Leu 
385                 390                 395                 400 


Arg Ser Leu Asn Leu Ala Trp Asn Lys Ile Ala Ile Ile His Pro Asn 
                405                 410                 415     


Ala Phe Ser Thr Leu Pro Ser Leu Ile Lys Leu Asp Leu Ser Ser Asn 
            420                 425                 430         


Leu Leu Ser Ser Phe Pro Val Thr Gly Leu His Gly Leu Thr His Leu 
        435                 440                 445             


Lys Leu Thr Gly Asn His Ala Leu Gln Ser Leu Ile Ser Ser Glu Asn 
    450                 455                 460                 


Phe Pro Glu Leu Lys Ile Ile Glu Met Pro Tyr Ala Tyr Gln Cys Cys 
465                 470                 475                 480 


Ala Phe Gly Val Cys Glu Asn Ala Tyr Lys Ile Ser Asn Gln Trp Asn 
                485                 490                 495     


Lys Gly Asp Asn Ser Ser Met Asp Asp Leu His Lys Lys Asp Ala Gly 
            500                 505                 510         


Met Phe Gln Val Gln Asp Glu Arg Asp Leu Glu Asp Phe Leu Leu Asp 
        515                 520                 525             


Phe Glu Glu Asp Leu Lys Ala Leu His Ser Val Gln Cys Ser Pro Ser 
    530                 535                 540                 


Pro Gly Pro Phe Lys Pro Cys Glu His Leu Leu Asp Gly Trp Leu Ile 
545                 550                 555                 560 


Arg Ile Gly Val Trp Thr Ile Ala Val Leu Ala Leu Thr Cys Asn Ala 
                565                 570                 575     


Leu Val Thr Ser Thr Val Phe Arg Ser Pro Leu Tyr Ile Ser Pro Ile 
            580                 585                 590         


Lys Leu Leu Ile Gly Val Ile Ala Val Val Asn Met Leu Thr Gly Val 
        595                 600                 605             


Ser Ser Ala Val Leu Ala Gly Val Asp Ala Phe Thr Phe Gly Ser Phe 
    610                 615                 620                 


Ala Arg His Gly Ala Trp Trp Glu Asn Gly Val Gly Cys Gln Val Ile 
625                 630                 635                 640 


Gly Phe Leu Ser Ile Phe Ala Ser Glu Ser Ser Val Phe Leu Leu Thr 
                645                 650                 655     


Leu Ala Ala Leu Glu Arg Gly Phe Ser Val Lys Cys Ser Ala Lys Phe 
            660                 665                 670         


Glu Thr Lys Ala Pro Phe Ser Ser Leu Lys Val Ile Ile Leu Leu Cys 
        675                 680                 685             


Ala Leu Leu Ala Leu Thr Met Ala Ala Val Pro Leu Leu Gly Gly Ser 
    690                 695                 700                 


Glu Tyr Gly Ala Ser Pro Leu Cys Leu Pro Leu Pro Phe Gly Glu Pro 
705                 710                 715                 720 


Ser Thr Thr Gly Tyr Met Val Ala Leu Ile Leu Leu Asn Ser Leu Cys 
                725                 730                 735     


Phe Leu Met Met Thr Ile Ala Tyr Thr Lys Leu Tyr Cys Asn Leu Asp 
            740                 745                 750         


Lys Gly Asp Leu Glu Asn Ile Trp Asp Cys Ser Met Val Lys His Ile 
        755                 760                 765             


Ala Leu Leu Leu Phe Thr Asn Cys Ile Leu Tyr Cys Pro Val Ala Phe 
    770                 775                 780                 


Leu Ser Phe Ser Ser Leu Leu Asn Leu Thr Phe Ile Ser Pro Glu Val 
785                 790                 795                 800 


Ile Lys Phe Ile Leu Leu Val Ile Val Pro Leu Pro Ala Cys Leu Asn 
                805                 810                 815     


Pro Leu Leu Tyr Ile Leu Phe Asn Pro His Phe Lys Glu Asp Leu Val 
            820                 825                 830         


Ser Leu Gly Lys Gln Thr Tyr Phe Trp Thr Arg Ser Lys His Pro Ser 
        835                 840                 845             


Leu Met Ser Ile Asn Ser Asp Asp Val Glu Lys Gln Ser Cys Asp Ser 
    850                 855                 860                 


Thr Gln Ala Leu Val Thr Phe Thr Ser Ser Ser Ile Ala Tyr Asp Leu 
865                 870                 875                 880 


Pro Pro Ser Ser Val Pro Ser Pro Ala Tyr Pro Val Thr Glu Ser Cys 
                885                 890                 895     


His Leu Ser Ser Val Ala Phe Val Pro Cys Leu 
            900                 905         


<210>  17
<211>  381
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MF1337


<220>
<221>  CDS
<222>  (1)..(381)

<400>  17
gag gtg cag ctg gtg gag act ggg gct gag gtg aag aag ccg ggg gcc         48
Glu Val Gln Leu Val Glu Thr Gly Ala Glu Val Lys Lys Pro Gly Ala           
1               5                   10                  15                

tca gtg aag gtc tcc tgc aag gct tct gac tac atc ttc acc aaa tat         96
Ser Val Lys Val Ser Cys Lys Ala Ser Asp Tyr Ile Phe Thr Lys Tyr           
            20                  25                  30                    

gac atc aac tgg gtg cgc cag gcc cct gga caa ggg ctt gaa tgg atg        144
Asp Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met           
        35                  40                  45                        

gga tgg atg agc gct aac act gga aac acg ggc tat gca cag aag ttc        192
Gly Trp Met Ser Ala Asn Thr Gly Asn Thr Gly Tyr Ala Gln Lys Phe           
    50                  55                  60                            

cag ggc aga gtc acc atg acc agg gac acg tcc ata aac aca gcc tac        240
Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Asn Thr Ala Tyr           
65                  70                  75                  80            

atg gag ctg agc agc ctg aca tct ggt gac acg gcc gtt tat ttc tgt        288
Met Glu Leu Ser Ser Leu Thr Ser Gly Asp Thr Ala Val Tyr Phe Cys           
                85                  90                  95                

gcg agg agt agt ctt ttc aag aca gag acg gcg ccc tac tat cac ttc        336
Ala Arg Ser Ser Leu Phe Lys Thr Glu Thr Ala Pro Tyr Tyr His Phe           
            100                 105                 110                   

gct ctg gac gtc tgg ggc caa ggg acc acg gtc acc gtc tcc agt            381
Ala Leu Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser               
        115                 120                 125                       


<210>  18
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  18

Glu Val Gln Leu Val Glu Thr Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Asp Tyr Ile Phe Thr Lys Tyr 
            20                  25                  30          


Asp Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Met Ser Ala Asn Thr Gly Asn Thr Gly Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Thr Ser Gly Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Ser Ser Leu Phe Lys Thr Glu Thr Ala Pro Tyr Tyr His Phe 
            100                 105                 110         


Ala Leu Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125         


<210>  19
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MF3755


<220>
<221>  CDS
<222>  (1)..(360)

<400>  19
cag gtg cag ctg gtg cag tct ggg tct gag ttg aag aag cct ggg gcc         48
Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala           
1               5                   10                  15                

tca gtg aag att tcc tgc aag gct tct gga tac gac ttc act aac tat         96
Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Asp Phe Thr Asn Tyr           
            20                  25                  30                    

gct atg aat tgg gtg cga cag gcc cct gga cac ggg ctt gag tgg atg        144
Ala Met Asn Trp Val Arg Gln Ala Pro Gly His Gly Leu Glu Trp Met           
        35                  40                  45                        

gga tgg atc aac gcc aac act ggg gac cca acg tat gcc cag ggc ttc        192
Gly Trp Ile Asn Ala Asn Thr Gly Asp Pro Thr Tyr Ala Gln Gly Phe           
    50                  55                  60                            

aca gga cgg ttt gtc ttc tcc ttg gac acc tct gtc agc acg gca tat        240
Thr Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Ser Thr Ala Tyr           
65                  70                  75                  80            

ctg cag atc agc agt tta aag gct gag gac tct gcc gtg tat tac tgt        288
Leu Gln Ile Ser Ser Leu Lys Ala Glu Asp Ser Ala Val Tyr Tyr Cys           
                85                  90                  95                

acg aga gag cga ttt ttg gag tgg tta cac ttt gac tac tgg ggc cag        336
Thr Arg Glu Arg Phe Leu Glu Trp Leu His Phe Asp Tyr Trp Gly Gln           
            100                 105                 110                   

gga acc ctg gtc acc gtc tcc agt                                        360
Gly Thr Leu Val Thr Val Ser Ser                                           
        115                 120                                           


<210>  20
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  20

Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Asp Phe Thr Asn Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly His Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Ala Asn Thr Gly Asp Pro Thr Tyr Ala Gln Gly Phe 
    50                  55                  60                  


Thr Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Ser Ser Leu Lys Ala Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Glu Arg Phe Leu Glu Trp Leu His Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  21
<211>  372
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MF3178


<220>
<221>  CDS
<222>  (1)..(372)

<400>  21
cag gtg cag ctg gtg cag tct ggg gct gag gtg aag aag cct ggg gcc         48
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala           
1               5                   10                  15                

tca gtg aag gtc tcc tgc aag gct tct gga tac acc ttc acc ggc tac         96
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr           
            20                  25                  30                    

tat atg cac tgg gtg cga cag gcc cct gga caa ggg ctt gag tgg atg        144
Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met           
        35                  40                  45                        

gga tgg atc aac cct aac agt ggt ggc aca aac tat gca cag aag ttt        192
Gly Trp Ile Asn Pro Asn Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe           
    50                  55                  60                            

cag ggc agg gtc acg atg acc agg gac acg tcc atc agc aca gcc tac        240
Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr           
65                  70                  75                  80            

atg gag ctg agc agg ctg aga tct gac gac acg gct gtg tat tac tgt        288
Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys           
                85                  90                  95                

gca aga gat cat ggt tct cgt cat ttc tgg tct tac tgg ggc ttt gat        336
Ala Arg Asp His Gly Ser Arg His Phe Trp Ser Tyr Trp Gly Phe Asp           
            100                 105                 110                   

tat tgg ggc caa ggt acc ctg gtc acc gtc tcc agt                        372
Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser                           
        115                 120                                           


<210>  22
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  22

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Pro Asn Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp His Gly Ser Arg His Phe Trp Ser Tyr Trp Gly Phe Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  23
<211>  378
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MF5790


<220>
<221>  CDS
<222>  (1)..(378)

<400>  23
cag gtg cag ctg cag gag tcg ggc cca gga ctg gtg aag cct tcg gag         48
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu           
1               5                   10                  15                

acc ctg tcc ctc acc tgc act gtc tct ggt ggc tcc ttc agc agt agt         96
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Phe Ser Ser Ser           
            20                  25                  30                    

agt tcc tac tgg ggc tgg atc cgc cag ccc cca ggg aag ggg ctg gag        144
Ser Ser Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu           
        35                  40                  45                        

tgg att ggg agt ttc tat tat agt ggg aac acc tac tac aac ccg tcc        192
Trp Ile Gly Ser Phe Tyr Tyr Ser Gly Asn Thr Tyr Tyr Asn Pro Ser           
    50                  55                  60                            

ctc aag agt cga gtc acc ata tcc gaa gac acg tcc aag aac cag ttc        240
Leu Lys Ser Arg Val Thr Ile Ser Glu Asp Thr Ser Lys Asn Gln Phe           
65                  70                  75                  80            

tcc ctg aag ctg agc tct gtg acc gcc gca gac acg gct gtg tat tac        288
Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr           
                85                  90                  95                

tgt gcg aga cag acg tat agc agc agc tgg gac ggg gtc ctg tac tac        336
Cys Ala Arg Gln Thr Tyr Ser Ser Ser Trp Asp Gly Val Leu Tyr Tyr           
            100                 105                 110                   

ttt gac tac tgg ggc cag gga acc ctg gtc acc gtc tcc agt                378
Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser                   
        115                 120                 125                       


<210>  24
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  24

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Phe Ser Ser Ser 
            20                  25                  30          


Ser Ser Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Ser Phe Tyr Tyr Ser Gly Asn Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Glu Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Gln Thr Tyr Ser Ser Ser Trp Asp Gly Val Leu Tyr Tyr 
            100                 105                 110         


Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     


<210>  25
<211>  381
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MF5816


<220>
<221>  CDS
<222>  (1)..(381)

<400>  25
gag gtg cag ctg gtg cag tct ggg tct aaa ttg aag aag cct ggg gcc         48
Glu Val Gln Leu Val Gln Ser Gly Ser Lys Leu Lys Lys Pro Gly Ala           
1               5                   10                  15                

tca gtg aag gtt tcc tgc aag gct tct gga tac acc ttc act agc tat         96
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr           
            20                  25                  30                    

act atg aat tgg gtg cga cag gcc cct gga caa ggg ctt gag tgg atg        144
Thr Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met           
        35                  40                  45                        

gga tgg atc aac acc gac act ggg gac cca acg tat gcc cag ggc ttc        192
Gly Trp Ile Asn Thr Asp Thr Gly Asp Pro Thr Tyr Ala Gln Gly Phe           
    50                  55                  60                            

aca gga cgg ttt gtc ttc tcc ttg gac acc tct gtc agc acg gca ttt        240
Thr Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Ser Thr Ala Phe           
65                  70                  75                  80            

cta cag atc aac agc cta aag gct gag gac act gcc gta tat tac tgt        288
Leu Gln Ile Asn Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys           
                85                  90                  95                

gcg aga gga gat tgt gat agt acc agc tgc tat aga tac agt tat ggt        336
Ala Arg Gly Asp Cys Asp Ser Thr Ser Cys Tyr Arg Tyr Ser Tyr Gly           
            100                 105                 110                   

tac gag gac tac tgg ggc cag gga acc ctg gtc acc gtc tcc agt            381
Tyr Glu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser               
        115                 120                 125                       


<210>  26
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  26

Glu Val Gln Leu Val Gln Ser Gly Ser Lys Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Thr Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Asp Thr Gly Asp Pro Thr Tyr Ala Gln Gly Phe 
    50                  55                  60                  


Thr Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Ser Thr Ala Phe 
65                  70                  75                  80  


Leu Gln Ile Asn Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Asp Cys Asp Ser Thr Ser Cys Tyr Arg Tyr Ser Tyr Gly 
            100                 105                 110         


Tyr Glu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125         


<210>  27
<211>  372
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MF3125


<220>
<221>  CDS
<222>  (1)..(372)

<400>  27
cag gtg cag ctg gtg gag tct ggg gga ggc gtg gtc cag cct ggg agg         48
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg           
1               5                   10                  15                

tcc ctg aga ctc tcc tgt gca gcc tct gga ttc acc ttc agt agc tat         96
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr           
            20                  25                  30                    

ggc atg cac tgg gtc cgc cag gct cca ggc aag ggg ctg gag tgg gtg        144
Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val           
        35                  40                  45                        

gca gtt ata tca tat gat gga agt aat aaa tac tat gca gac tcc gtg        192
Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val           
    50                  55                  60                            

aag ggc cga ttc acc atc tcc aga gac aat tcc aag aac acg ctg tat        240
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr           
65                  70                  75                  80            

ctg caa atg aac agc ctg aga gct gag gac acg gcc gtg tat tac tgt        288
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys           
                85                  90                  95                

gca aaa ggt tct tct ggt tgg ccg tct tac tct aac tgg ggc ttt gat        336
Ala Lys Gly Ser Ser Gly Trp Pro Ser Tyr Ser Asn Trp Gly Phe Asp           
            100                 105                 110                   

tat tgg ggc caa ggt acc ctg gtc acc gtc tcc agt                        372
Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser                           
        115                 120                                           


<210>  28
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  28

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Ser Ser Gly Trp Pro Ser Tyr Ser Asn Trp Gly Phe Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  29
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MF3176


<220>
<221>  CDS
<222>  (1)..(366)

<400>  29
gag gtg cag ctg ttg gag tct ggg gga ggc ttg gta cag cct ggg ggg         48
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly           
1               5                   10                  15                

tcc ctg aga ctc tcc tgt gca gcc tct gga ttc acc ttt agc agc tat         96
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr           
            20                  25                  30                    

gcc atg agc tgg gtc cgc cag gct cca ggg aag ggg ctg gag tgg gtc        144
Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val           
        35                  40                  45                        

tca gct att agt ggt agt ggt ggt agc aca tac tac gca gac tcc gtg        192
Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val           
    50                  55                  60                            

aag ggc cgg ttc acc atc tcc aga gac aat tcc aag aac acg ctg tat        240
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr           
65                  70                  75                  80            

ctg caa atg aac agc ctg aga gcc gag gac acg gct gtg tat tac tgt        288
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys           
                85                  90                  95                

gca aga gat tgg tgg tac ccg ccg tac tac tgg ggc ttt gat tat tgg        336
Ala Arg Asp Trp Trp Tyr Pro Pro Tyr Tyr Trp Gly Phe Asp Tyr Trp           
            100                 105                 110                   

ggc caa ggt acc ctg gtc acc gtc tcc agt                                366
Gly Gln Gly Thr Leu Val Thr Val Ser Ser                                   
        115                 120                                           


<210>  30
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  30

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Trp Trp Tyr Pro Pro Tyr Tyr Trp Gly Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  31
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MF4863


<220>
<221>  CDS
<222>  (1)..(366)

<400>  31
gag gtg cag ctg gtg cag tct ggg tct gag ttg aag aag cct ggg gcc         48
Glu Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala           
1               5                   10                  15                

tca gtg aag gtt tcc tgc aag gct tct gga tac acc tcc att aga tat         96
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Ser Ile Arg Tyr           
            20                  25                  30                    

gct ttg aac tgg gtg cga cag gcc cct gga caa ggc ctt gag tgg ctg        144
Ala Leu Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Leu           
        35                  40                  45                        

gga tgg atc aac acc aac act ggg aac cca acg tat gcc cgg ggc ttc        192
Gly Trp Ile Asn Thr Asn Thr Gly Asn Pro Thr Tyr Ala Arg Gly Phe           
    50                  55                  60                            

aca gga cgg ttt gtc ttc tcc ttg gac acc tct gtc agc acg gca tat        240
Thr Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Ser Thr Ala Tyr           
65                  70                  75                  80            

ctg cag atc agc agc cta aag gct gag gac act gcc gtg tat tac tgt        288
Leu Gln Ile Ser Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys           
                85                  90                  95                

gcg aga gat act tat gat agt act ggt tat ctt tgg ttt gac tac tgg        336
Ala Arg Asp Thr Tyr Asp Ser Thr Gly Tyr Leu Trp Phe Asp Tyr Trp           
            100                 105                 110                   

ggc cag gga acc ctg gtc acc gtc tcc agt                                366
Gly Gln Gly Thr Leu Val Thr Val Ser Ser                                   
        115                 120                                           


<210>  32
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  32

Glu Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Ser Ile Arg Tyr 
            20                  25                  30          


Ala Leu Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Trp Ile Asn Thr Asn Thr Gly Asn Pro Thr Tyr Ala Arg Gly Phe 
    50                  55                  60                  


Thr Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Ser Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Thr Tyr Asp Ser Thr Gly Tyr Leu Trp Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  33
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MF3370


<220>
<221>  CDS
<222>  (1)..(366)

<400>  33
cag gtt cag ctg gtg cag tct gga gct gag gtg aag aag cct ggg gcc         48
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala           
1               5                   10                  15                

tca gtg aag gtc tcc tgc aag gct tct ggt tac acc ttt acc agc tat         96
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr           
            20                  25                  30                    

ggt atc agc tgg gtg cga cag gcc cct gga caa ggg ctt gag tgg atg        144
Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met           
        35                  40                  45                        

gga tgg atc agc gct tac aat ggt aac aca aac tat gca cag aag ctc        192
Gly Trp Ile Ser Ala Tyr Asn Gly Asn Thr Asn Tyr Ala Gln Lys Leu           
    50                  55                  60                            

cag ggc aga gtc acc atg acc aca gac aca tcc acg agc aca gcc tac        240
Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr           
65                  70                  75                  80            

atg gag ctg agg agc ctg aga tct gac gac acg gct gtg tat tac tgt        288
Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys           
                85                  90                  95                

gca aaa gat cgt cat tgg cat tgg tgg ctg gac gcc ttt gat tat tgg        336
Ala Lys Asp Arg His Trp His Trp Trp Leu Asp Ala Phe Asp Tyr Trp           
            100                 105                 110                   

ggc caa ggt acc ctg gtc acc gtc tcc agt                                366
Gly Gln Gly Thr Leu Val Thr Val Ser Ser                                   
        115                 120                                           


<210>  34
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  34

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Ser Ala Tyr Asn Gly Asn Thr Asn Tyr Ala Gln Lys Leu 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Arg His Trp His Trp Trp Leu Asp Ala Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  35
<211>  375
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MF4280


<220>
<221>  CDS
<222>  (1)..(375)

<400>  35
cag gtg cag ctg gtg cag tct ggg gct gag gtg aag aag cct ggg gcc         48
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala           
1               5                   10                  15                

tca gtg aag gtc tcc tgc aag gtt tcc gga tac acc ctc act gaa tta         96
Ser Val Lys Val Ser Cys Lys Val Ser Gly Tyr Thr Leu Thr Glu Leu           
            20                  25                  30                    

tcc atg cac tgg gtg cga cag gct cct ggt aaa ggg ctt gaa tgg atg        144
Ser Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met           
        35                  40                  45                        

gga ggc ttt gat cct gag tat ggt aaa aca ttc ttc gca cag aac ttc        192
Gly Gly Phe Asp Pro Glu Tyr Gly Lys Thr Phe Phe Ala Gln Asn Phe           
    50                  55                  60                            

cag ggc aga gtc acc atg acc gag gac aca tct gca gac aca gcc tac        240
Gln Gly Arg Val Thr Met Thr Glu Asp Thr Ser Ala Asp Thr Ala Tyr           
65                  70                  75                  80            

atg gag cta agc agc ctg aga tct gag gac acg gcc gtg tat tac tgt        288
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys           
                85                  90                  95                

gca aca gag ggg tat tat gag act act act tat tac tac aac ctt ttt        336
Ala Thr Glu Gly Tyr Tyr Glu Thr Thr Thr Tyr Tyr Tyr Asn Leu Phe           
            100                 105                 110                   

gac tcc tgg ggc cag gga acc ctg gtc acc gtc tcc agt                    375
Asp Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser                       
        115                 120                 125                       


<210>  36
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  36

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Val Ser Gly Tyr Thr Leu Thr Glu Leu 
            20                  25                  30          


Ser Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Phe Asp Pro Glu Tyr Gly Lys Thr Phe Phe Ala Gln Asn Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Glu Asp Thr Ser Ala Asp Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Glu Gly Tyr Tyr Glu Thr Thr Thr Tyr Tyr Tyr Asn Leu Phe 
            100                 105                 110         


Asp Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  37
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MF4289


<220>
<221>  CDS
<222>  (1)..(357)

<400>  37
cag gtg cag ctg gtg caa tct ggg tct gaa ttg aag aag cct ggg gcc         48
Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala           
1               5                   10                  15                

tca gtg aag gtt tcc tgc aag act tct gga tac acc ttc act gac tat         96
Ser Val Lys Val Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Asp Tyr           
            20                  25                  30                    

gct atg act tgg gtg cga cag gcc cct gga caa ggg ctt gaa tgg atg        144
Ala Met Thr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met           
        35                  40                  45                        

gga tgg atc acc acc aac act ggg gac cca acg tat gcc ccg ggc ttc        192
Gly Trp Ile Thr Thr Asn Thr Gly Asp Pro Thr Tyr Ala Pro Gly Phe           
    50                  55                  60                            

aca gga cgg ttt gtc ttc tcc ttg gac acc tct gtc agc acg gca tat        240
Thr Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Ser Thr Ala Tyr           
65                  70                  75                  80            

ctg cag atc agc agc cta aag gcc gag gac act gcc gta tat tac tgt        288
Leu Gln Ile Ser Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys           
                85                  90                  95                

gcg aga gtg tat cat tgg ata cgg gga ttt gag ttt tgg ggc cag gga        336
Ala Arg Val Tyr His Trp Ile Arg Gly Phe Glu Phe Trp Gly Gln Gly           
            100                 105                 110                   

acc ctg gtc acc gtc tcc agt                                            357
Thr Leu Val Thr Val Ser Ser                                               
        115                                                               


<210>  38
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  38

Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ala Met Thr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Thr Thr Asn Thr Gly Asp Pro Thr Tyr Ala Pro Gly Phe 
    50                  55                  60                  


Thr Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Ser Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Val Tyr His Trp Ile Arg Gly Phe Glu Phe Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  39
<211>  345
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MF5777


<220>
<221>  CDS
<222>  (1)..(345)

<400>  39
cag gtg cag ctg gtg caa tct ggg tct gag ttg aag aag cct ggg gcc         48
Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala           
1               5                   10                  15                

tca gtg aag gtt tcc tgc aag gct tct gga tac acc ttc act aac tat         96
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr           
            20                  25                  30                    

gtt atg aat tgg gtg cga cag gcc cct gga caa ggg ctt gag tgg atg        144
Val Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met           
        35                  40                  45                        

gga tgg atc aac acc aac act ggg aac cca acg tat gcc cag ggc ttc        192
Gly Trp Ile Asn Thr Asn Thr Gly Asn Pro Thr Tyr Ala Gln Gly Phe           
    50                  55                  60                            

aca gga cgg ttt gtc ttc tcc ttg gac acc tct gtc agc acg gca tat        240
Thr Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Ser Thr Ala Tyr           
65                  70                  75                  80            

ctg cag atc agc agc cta aag gct gag gac act gcc gtg tat tac tgt        288
Leu Gln Ile Ser Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys           
                85                  90                  95                

gcg agg tgg gag cta cta gac tac tgg ggc cag gga acc ctg gtc acc        336
Ala Arg Trp Glu Leu Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr           
            100                 105                 110                   

gtc tcc agt                                                            345
Val Ser Ser                                                               
        115                                                               


<210>  40
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  40

Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Val Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Asn Thr Gly Asn Pro Thr Tyr Ala Gln Gly Phe 
    50                  55                  60                  


Thr Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Ser Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Glu Leu Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  41
<211>  348
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MF5781


<220>
<221>  CDS
<222>  (1)..(348)

<400>  41
gag gtg cag ctg gtg gag tct ggg gga ggc ttg gta cag cct ggg ggg         48
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly           
1               5                   10                  15                

tcc ctg aga ctc tcc tgt gca gcc tct gga ttc acc ttt agc agc tat         96
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr           
            20                  25                  30                    

gcc atg agc tgg gtc cgc cag gct cca ggg aag ggg ctg gag tgg gtc        144
Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val           
        35                  40                  45                        

tca gtt att agt ggt agt ggt ggg acc aca tac tac gca gac tcc gtg        192
Ser Val Ile Ser Gly Ser Gly Gly Thr Thr Tyr Tyr Ala Asp Ser Val           
    50                  55                  60                            

aag ggc cgg ttc acc atc tcc aga gac aat tcc aag aac acg ctg tat        240
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr           
65                  70                  75                  80            

ctg caa atg aac agc ctg aga gcc gag gac acg gcc gta tat tac tgt        288
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys           
                85                  90                  95                

gcg aaa ggg gct ggg gag ctt gac tac tgg ggc cag gga acc ctg gtc        336
Ala Lys Gly Ala Gly Glu Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val           
            100                 105                 110                   

acc gtc tcc agt                                                        348
Thr Val Ser Ser                                                           
        115                                                               


<210>  42
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  42

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Ser Gly Ser Gly Gly Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Ala Gly Glu Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  43
<211>  378
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MF5803


<220>
<221>  CDS
<222>  (1)..(378)

<400>  43
cag gtg cag ctg cag gag tcg ggg cca gga ctg gtg aag cct tcg gag         48
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu           
1               5                   10                  15                

acc ctg tcc ctc acc tgc act gtc tct aat ggc tcc atc agt act tac         96
Thr Leu Ser Leu Thr Cys Thr Val Ser Asn Gly Ser Ile Ser Thr Tyr           
            20                  25                  30                    

tac tgg agc tgg atc cgg cag ccc cca ggg aag ggg ctg gag tgg att        144
Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile           
        35                  40                  45                        

gga tat gtc tat tac act ggg cgc acc aag tac aac ccc tcc ctc aag        192
Gly Tyr Val Tyr Tyr Thr Gly Arg Thr Lys Tyr Asn Pro Ser Leu Lys           
    50                  55                  60                            

agt cga gtc acc ata tca gta gac acg tcc aag aac cag ttc tcc ctg        240
Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu           
65                  70                  75                  80            

aac ctg agt tct gtg acc gct gcg gac acg gcc gtg tat tac tgt gcg        288
Asn Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala           
                85                  90                  95                

aga ggg ggt att gta gta gtc cca gct gcg cgg gac tat tac tac tac        336
Arg Gly Gly Ile Val Val Val Pro Ala Ala Arg Asp Tyr Tyr Tyr Tyr           
            100                 105                 110                   

atg gac gtc tgg ggc aaa ggg acc acg gtc acc gtc tcc agt                378
Met Asp Val Trp Gly Lys Gly Thr Thr Val Thr Val Ser Ser                   
        115                 120                 125                       


<210>  44
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  44

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Asn Gly Ser Ile Ser Thr Tyr 
            20                  25                  30          


Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Val Tyr Tyr Thr Gly Arg Thr Lys Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Asn Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Gly Gly Ile Val Val Val Pro Ala Ala Arg Asp Tyr Tyr Tyr Tyr 
            100                 105                 110         


Met Asp Val Trp Gly Lys Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125     


<210>  45
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MF5805


<220>
<221>  CDS
<222>  (1)..(360)

<400>  45
gag gtg caa ctg gtg cag tct gga gca gag gtg aaa aag ccc ggg gag         48
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu           
1               5                   10                  15                

tct ctg aag atc gcc tgt aag ggt tct gga ttc agt ttt acc agc cac         96
Ser Leu Lys Ile Ala Cys Lys Gly Ser Gly Phe Ser Phe Thr Ser His           
            20                  25                  30                    

tgg atc ggc tgg gtg cgc cag aag ccc ggg aga ggc ctg gag tgg atg        144
Trp Ile Gly Trp Val Arg Gln Lys Pro Gly Arg Gly Leu Glu Trp Met           
        35                  40                  45                        

ggg gtc atc tat cct ggt gac tct gat acc aga tac agc ccg tcc ttc        192
Gly Val Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe           
    50                  55                  60                            

caa ggc cag gtc acc gtc tca gcc gac aag tcc atc aat acc gcc tac        240
Gln Gly Gln Val Thr Val Ser Ala Asp Lys Ser Ile Asn Thr Ala Tyr           
65                  70                  75                  80            

ctg cag tgg aac agc ctg aag gcc tcg gac acc gcc ata tat tac tgt        288
Leu Gln Trp Asn Ser Leu Lys Ala Ser Asp Thr Ala Ile Tyr Tyr Cys           
                85                  90                  95                

gcg aga ccg aac agt ggg agt ccc cgg tac ttc gag ttc tgg ggc cgt        336
Ala Arg Pro Asn Ser Gly Ser Pro Arg Tyr Phe Glu Phe Trp Gly Arg           
            100                 105                 110                   

ggc acc ctg gtc acc gtc tcc agt                                        360
Gly Thr Leu Val Thr Val Ser Ser                                           
        115                 120                                           


<210>  46
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  46

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ala Cys Lys Gly Ser Gly Phe Ser Phe Thr Ser His 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Lys Pro Gly Arg Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Val Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Val Ser Ala Asp Lys Ser Ile Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Asn Ser Leu Lys Ala Ser Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Pro Asn Ser Gly Ser Pro Arg Tyr Phe Glu Phe Trp Gly Arg 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  47
<211>  378
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MF5808


<220>
<221>  CDS
<222>  (1)..(378)

<400>  47
cag gtg cag ctg cag gag tcg ggc cca gga ctg gtg aag cct tcg gag         48
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu           
1               5                   10                  15                

acc ctg tcc ctc acc tgc act gtc tct ggt ggc tcc atc agc agt agt         96
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Ser           
            20                  25                  30                    

agt tac tac tgg ggc tgg atc cgc cag ccc cca ggg aag ggg ctg gag        144
Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu           
        35                  40                  45                        

tgg att ggg agt ttc tat tat agt ggg aac acc tac tac aac ccg tcc        192
Trp Ile Gly Ser Phe Tyr Tyr Ser Gly Asn Thr Tyr Tyr Asn Pro Ser           
    50                  55                  60                            

ctc aag agt cga gtc acc ata tcc gta gac acg tcc aag aac cag ttc        240
Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe           
65                  70                  75                  80            

tcc ctg aag ctg agc tct gtg acc gcc gca gac acg gct gtg tat tac        288
Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr           
                85                  90                  95                

tgt gcg aga cag gag tat tac tat ggt tcg ggg agt cct tcg tac tac        336
Cys Ala Arg Gln Glu Tyr Tyr Tyr Gly Ser Gly Ser Pro Ser Tyr Tyr           
            100                 105                 110                   

ttt gac tac tgg ggc cag gga acc ctg gtc acc gtc tcc agt                378
Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser                   
        115                 120                 125                       


<210>  48
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  48

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Ser 
            20                  25                  30          


Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Ser Phe Tyr Tyr Ser Gly Asn Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Gln Glu Tyr Tyr Tyr Gly Ser Gly Ser Pro Ser Tyr Tyr 
            100                 105                 110         


Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     


<210>  49
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MF5809


<220>
<221>  CDS
<222>  (1)..(360)

<400>  49
gag gtg cag ctg gtg cag tct gga gca gag gtg aaa aag ccc ggg gag         48
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu           
1               5                   10                  15                

tct ctg aag atc tcc tgt aag ggt tct gga gac agt ttt atc agc cac         96
Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Asp Ser Phe Ile Ser His           
            20                  25                  30                    

tgg atc gcc tgg gtg cgc cag atg ccc ggg aaa ggc ctg gag tgg atg        144
Trp Ile Ala Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met           
        35                  40                  45                        

ggg atc gtc tat cct ggt gac tct gat acc aga tac agc ccg tcc ttc        192
Gly Ile Val Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe           
    50                  55                  60                            

caa ggc cag gtc acc atc tca gcc gac aag tcc atc acc acc gcc tac        240
Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Thr Thr Ala Tyr           
65                  70                  75                  80            

ttg cag tgg agc agc ctg aag gcc tcg gac acc gcc atg tat tac tgt        288
Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys           
                85                  90                  95                

gcg aga cac gag tgg gaa cta ctt ggc ccc ttt gac tac tgg ggc cag        336
Ala Arg His Glu Trp Glu Leu Leu Gly Pro Phe Asp Tyr Trp Gly Gln           
            100                 105                 110                   

gga acc ctg gtc acc gtc tcc agt                                        360
Gly Thr Leu Val Thr Val Ser Ser                                           
        115                 120                                           


<210>  50
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  50

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Asp Ser Phe Ile Ser His 
            20                  25                  30          


Trp Ile Ala Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Val Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Thr Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg His Glu Trp Glu Leu Leu Gly Pro Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  51
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MF5814


<220>
<221>  CDS
<222>  (1)..(363)

<400>  51
gag gtg cag ctg gtg cag tct ggg gct gag gtg aag aag cct ggg tcc         48
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser           
1               5                   10                  15                

tcg gtg aag gtc tcc tgc aag gct tct gga ggc acc tcc act aac gat         96
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Ser Thr Asn Asp           
            20                  25                  30                    

gct atc agt tgg gtg cga cag acc cct gga caa ggg ctt gag tgg atg        144
Ala Ile Ser Trp Val Arg Gln Thr Pro Gly Gln Gly Leu Glu Trp Met           
        35                  40                  45                        

gga agt atc atc cct atc ctt gat aca aca gac cac gca cag aag ttc        192
Gly Ser Ile Ile Pro Ile Leu Asp Thr Thr Asp His Ala Gln Lys Phe           
    50                  55                  60                            

cag ggc aga gtc acg att acc gcg gac aaa tcc acg aac aca gcc tac        240
Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Asn Thr Ala Tyr           
65                  70                  75                  80            

atg gag ctg aac agc ctg aga tct gat gac acg gcc gtg tat tac tgt        288
Met Glu Leu Asn Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys           
                85                  90                  95                

gcg aga gag cat ata gca gct cgt cag gac tac ttt gac tat tgg ggc        336
Ala Arg Glu His Ile Ala Ala Arg Gln Asp Tyr Phe Asp Tyr Trp Gly           
            100                 105                 110                   

cag gga acc ctg gtc acc gtc tcc agt                                    363
Gln Gly Thr Leu Val Thr Val Ser Ser                                       
        115                 120                                           


<210>  52
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  52

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Ser Thr Asn Asp 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Thr Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ser Ile Ile Pro Ile Leu Asp Thr Thr Asp His Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Asn Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu His Ile Ala Ala Arg Gln Asp Tyr Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  53
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MF5817


<220>
<221>  CDS
<222>  (1)..(357)

<400>  53
cag gtg cag ctg gtg cag tct ggg gct gag gtg aag aag cct ggg tcc         48
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser           
1               5                   10                  15                

tcg gtg aag gtc tcc tgc aag gtt tct gga ggc acc ttc agg agc tat         96
Ser Val Lys Val Ser Cys Lys Val Ser Gly Gly Thr Phe Arg Ser Tyr           
            20                  25                  30                    

gct atc agc tgg gtg cga cag gcc cct gga caa ggg ctt gag tgg atg        144
Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met           
        35                  40                  45                        

gga ggg atc atc cct atc ttt gat aca aga aac tac gca cag att ctt        192
Gly Gly Ile Ile Pro Ile Phe Asp Thr Arg Asn Tyr Ala Gln Ile Leu           
    50                  55                  60                            

cag ggc aga gtc acg att acc gcg gac tta tcc acg agc aca gcc tac        240
Gln Gly Arg Val Thr Ile Thr Ala Asp Leu Ser Thr Ser Thr Ala Tyr           
65                  70                  75                  80            

atg gag ctg aac agt ctg aga tct gag gac acg gcc att tat tac tgt        288
Met Glu Leu Asn Ser Leu Arg Ser Glu Asp Thr Ala Ile Tyr Tyr Cys           
                85                  90                  95                

gcg aga ggg agc gac gag ggg gac tgg ttc gac ccc tgg ggc caa gga        336
Ala Arg Gly Ser Asp Glu Gly Asp Trp Phe Asp Pro Trp Gly Gln Gly           
            100                 105                 110                   

acc ctg gtc acc gtc tcc agt                                            357
Thr Leu Val Thr Val Ser Ser                                               
        115                                                               


<210>  54
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  54

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Val Ser Gly Gly Thr Phe Arg Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Asp Thr Arg Asn Tyr Ala Gln Ile Leu 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Leu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Asn Ser Leu Arg Ser Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ser Asp Glu Gly Asp Trp Phe Asp Pro Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  55
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MF5818


<220>
<221>  CDS
<222>  (1)..(363)

<400>  55
gag gtg cag ctg gtg cag tct ggg act gag gtg agg aag cct ggg tcc         48
Glu Val Gln Leu Val Gln Ser Gly Thr Glu Val Arg Lys Pro Gly Ser           
1               5                   10                  15                

tcg gtg aag gtc tcc tgc aag gct tct gga ggc acc ttc agc aac tat         96
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Asn Tyr           
            20                  25                  30                    

gct atc agc tgg gtg cga cag gcc cct gga cag ggg ctt gag tgg atg        144
Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met           
        35                  40                  45                        

gga agt atc atc cct atc ctt gga aca aca gac cac gca cag aag ttc        192
Gly Ser Ile Ile Pro Ile Leu Gly Thr Thr Asp His Ala Gln Lys Phe           
    50                  55                  60                            

cag gac aga gtc acg att acc gcg gac aaa tcc tcg aac aca acc tac        240
Gln Asp Arg Val Thr Ile Thr Ala Asp Lys Ser Ser Asn Thr Thr Tyr           
65                  70                  75                  80            

atg gag ctg agc agc ctg aga tct gat gac acg gcc gta tat tac tgt        288
Met Glu Leu Ser Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys           
                85                  90                  95                

gcg aga gag tat ata gca gct cgt ctg gac tac ttt gac tct tgg ggc        336
Ala Arg Glu Tyr Ile Ala Ala Arg Leu Asp Tyr Phe Asp Ser Trp Gly           
            100                 105                 110                   

cag gga acc ctg gtc acc gtc tcc agt                                    363
Gln Gly Thr Leu Val Thr Val Ser Ser                                       
        115                 120                                           


<210>  56
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  56

Glu Val Gln Leu Val Gln Ser Gly Thr Glu Val Arg Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Asn Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ser Ile Ile Pro Ile Leu Gly Thr Thr Asp His Ala Gln Lys Phe 
    50                  55                  60                  


Gln Asp Arg Val Thr Ile Thr Ala Asp Lys Ser Ser Asn Thr Thr Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Tyr Ile Ala Ala Arg Leu Asp Tyr Phe Asp Ser Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  57
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MF5832


<220>
<221>  CDS
<222>  (1)..(366)

<400>  57
gag gtg cag ctg gtg gag tct ggg gga ggc ttg gta cag cct ggg ggg         48
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly           
1               5                   10                  15                

tcc ctg aga ctc tcc tgt gta gtc tct gga ttc acc ttc agt tac tac         96
Ser Leu Arg Leu Ser Cys Val Val Ser Gly Phe Thr Phe Ser Tyr Tyr           
            20                  25                  30                    

gac atg cac tgg gtc cgc caa gtc aca gga aaa ggt ctg gag tgg gtc        144
Asp Met His Trp Val Arg Gln Val Thr Gly Lys Gly Leu Glu Trp Val           
        35                  40                  45                        

tca gct att ggc act gct ggt gcc aca tac tat cca ggc tcc gtg aag        192
Ser Ala Ile Gly Thr Ala Gly Ala Thr Tyr Tyr Pro Gly Ser Val Lys           
    50                  55                  60                            

ggc cga ttc acc atc tcc aga gaa aat gcc aag aac tcc ttg tat ctt        240
Gly Arg Phe Thr Ile Ser Arg Glu Asn Ala Lys Asn Ser Leu Tyr Leu           
65                  70                  75                  80            

caa atg aat agc ctg aga gcc ggg gac acg gct gtg tat tac tgt gca        288
Gln Met Asn Ser Leu Arg Ala Gly Asp Thr Ala Val Tyr Tyr Cys Ala           
                85                  90                  95                

aga gat cgt gga tat agt ggc tac gat gcg tac tac ttt gac ttc tgg        336
Arg Asp Arg Gly Tyr Ser Gly Tyr Asp Ala Tyr Tyr Phe Asp Phe Trp           
            100                 105                 110                   

ggc cag gga acc ctg gtc acc gtc tcc agt                                366
Gly Gln Gly Thr Leu Val Thr Val Ser Ser                                   
        115                 120                                           


<210>  58
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  58

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Val Ser Gly Phe Thr Phe Ser Tyr Tyr 
            20                  25                  30          


Asp Met His Trp Val Arg Gln Val Thr Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Gly Thr Ala Gly Ala Thr Tyr Tyr Pro Gly Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Glu Asn Ala Lys Asn Ser Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Gly Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Arg Gly Tyr Ser Gly Tyr Asp Ala Tyr Tyr Phe Asp Phe Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  59
<211>  372
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MF5836


<220>
<221>  CDS
<222>  (1)..(372)

<400>  59
cag gtg cag ctg cag gag tcg ggc cca gga ctg gtg aag cct tcg gag         48
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu           
1               5                   10                  15                

acc ctg tcc ctc acc tgc act gtc tct ggt ggc tcc atc agc agt agt         96
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Ser           
            20                  25                  30                    

aat tac tac tgg ggc tgg atc cgc cag ccc cca ggg aag ggg ctg gag        144
Asn Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu           
        35                  40                  45                        

tgg att ggg aat atc tat tat aga ggg tac acc tat tat aac ccg tcc        192
Trp Ile Gly Asn Ile Tyr Tyr Arg Gly Tyr Thr Tyr Tyr Asn Pro Ser           
    50                  55                  60                            

ctc aag agt cga gtc acc ata tcc gta gac acg tcc aag aag cag ttc        240
Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Lys Gln Phe           
65                  70                  75                  80            

tcc ctg acg ctg agc tct gtg acc gcc gca gac acg gct atg tat tac        288
Ser Leu Thr Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Met Tyr Tyr           
                85                  90                  95                

tgt gcg aga gag ggg agt gac tac ggt gac tac gta gga gct ttt gat        336
Cys Ala Arg Glu Gly Ser Asp Tyr Gly Asp Tyr Val Gly Ala Phe Asp           
            100                 105                 110                   

atc tgg gac caa ggg aca atg gtc acc gtc tcc agt                        372
Ile Trp Asp Gln Gly Thr Met Val Thr Val Ser Ser                           
        115                 120                                           


<210>  60
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  60

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Ser 
            20                  25                  30          


Asn Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Asn Ile Tyr Tyr Arg Gly Tyr Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Lys Gln Phe 
65                  70                  75                  80  


Ser Leu Thr Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Met Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Glu Gly Ser Asp Tyr Gly Asp Tyr Val Gly Ala Phe Asp 
            100                 105                 110         


Ile Trp Asp Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120                 


<210>  61
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MF5839


<220>
<221>  CDS
<222>  (1)..(366)

<400>  61
gag gtg cag ctg gtg cag tct ggg gga ggc ttg gta cag cct ggg ggg         48
Glu Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly           
1               5                   10                  15                

tcc ctg aga ctc tcc tgt gca gcc tct gga ttc acc ttc agt tac tac         96
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Tyr Tyr           
            20                  25                  30                    

gac atg cac tgg gtc cgc caa gtt aca gga aaa ggt ctg gag tgg gtc        144
Asp Met His Trp Val Arg Gln Val Thr Gly Lys Gly Leu Glu Trp Val           
        35                  40                  45                        

tca act att ggt gct act ggt gac aca tac tat tca gac tcc gtg aag        192
Ser Thr Ile Gly Ala Thr Gly Asp Thr Tyr Tyr Ser Asp Ser Val Lys           
    50                  55                  60                            

ggc cga ttt acc atc tcc aga caa aat gcc aag aac tcc ttg tat ctt        240
Gly Arg Phe Thr Ile Ser Arg Gln Asn Ala Lys Asn Ser Leu Tyr Leu           
65                  70                  75                  80            

caa ata aac agc ctg aga gcc ggg gac acg gct gta tat tac tgt gta        288
Gln Ile Asn Ser Leu Arg Ala Gly Asp Thr Ala Val Tyr Tyr Cys Val           
                85                  90                  95                

aga gat cgt gga tat att ggc tac gat tcg tac tac ttt gac aac tgg        336
Arg Asp Arg Gly Tyr Ile Gly Tyr Asp Ser Tyr Tyr Phe Asp Asn Trp           
            100                 105                 110                   

ggc cag gga acc ctg gtc acc gtc tcc agt                                366
Gly Gln Gly Thr Leu Val Thr Val Ser Ser                                   
        115                 120                                           


<210>  62
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  62

Glu Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Tyr Tyr 
            20                  25                  30          


Asp Met His Trp Val Arg Gln Val Thr Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Gly Ala Thr Gly Asp Thr Tyr Tyr Ser Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Gln Asn Ala Lys Asn Ser Leu Tyr Leu 
65                  70                  75                  80  


Gln Ile Asn Ser Leu Arg Ala Gly Asp Thr Ala Val Tyr Tyr Cys Val 
                85                  90                  95      


Arg Asp Arg Gly Tyr Ile Gly Tyr Asp Ser Tyr Tyr Phe Asp Asn Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  63
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  M5850


<220>
<221>  CDS
<222>  (1)..(360)

<400>  63
cag gtg cag ctg gtg cag tct ggg tct gag ttg aag aag cct ggg gcc         48
Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala           
1               5                   10                  15                

tca gtg aag gtt tcc tgc aag gct tct gga tac acc ttc act agg tat         96
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Tyr           
            20                  25                  30                    

cct atg aat tgg gtg cga cag gcc cct gga caa ggg ctt gag tgg atg        144
Pro Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met           
        35                  40                  45                        

gga tgg atc aac acc aac act ggg aac cca aca tat gcc cag ggc ttc        192
Gly Trp Ile Asn Thr Asn Thr Gly Asn Pro Thr Tyr Ala Gln Gly Phe           
    50                  55                  60                            

aca gga cgg ttt gtc ttc tcc ttg gac acc tct gtc agc acg gca ttt        240
Thr Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Ser Thr Ala Phe           
65                  70                  75                  80            

ctg cag atc agc agc cta aag gct gag gac act gcc gtg tat tac tgt        288
Leu Gln Ile Ser Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys           
                85                  90                  95                

gcg aga gag agg act aac ttt tat gat gct ttt gat atc tgg ggc caa        336
Ala Arg Glu Arg Thr Asn Phe Tyr Asp Ala Phe Asp Ile Trp Gly Gln           
            100                 105                 110                   

ggg aca atg gtc acc gtc tcc agt                                        360
Gly Thr Met Val Thr Val Ser Ser                                           
        115                 120                                           


<210>  64
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  64

Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Tyr 
            20                  25                  30          


Pro Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Asn Thr Gly Asn Pro Thr Tyr Ala Gln Gly Phe 
    50                  55                  60                  


Thr Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Ser Thr Ala Phe 
65                  70                  75                  80  


Leu Gln Ile Ser Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Arg Thr Asn Phe Tyr Asp Ala Phe Asp Ile Trp Gly Gln 
            100                 105                 110         


Gly Thr Met Val Thr Val Ser Ser 
        115                 120 


<210>  65
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MF5853


<220>
<221>  CDS
<222>  (1)..(360)

<400>  65
cag gtg cag ctg gtg caa tct ggg tct gag ttg aag aag cct ggg gcc         48
Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala           
1               5                   10                  15                

tca gtg aag gtt tcc tgc aag gct tct gga tat acc ttc aat agc tat         96
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Asn Ser Tyr           
            20                  25                  30                    

gct atg gat tgg gtg cga cag gcc cct gga caa ggg ctt gag tgg atg        144
Ala Met Asp Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met           
        35                  40                  45                        

gga tgg atc aac acc aat act ggg aac cca acg tat gcc cag gcc ttc        192
Gly Trp Ile Asn Thr Asn Thr Gly Asn Pro Thr Tyr Ala Gln Ala Phe           
    50                  55                  60                            

aca gga cgg ttt gtc ttc tcc ttg gac acc tct gtc agc acg gca tat        240
Thr Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Ser Thr Ala Tyr           
65                  70                  75                  80            

ctg gag atc agc agc cta aag gct gag gac act gcc gtg tat tac tgt        288
Leu Glu Ile Ser Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys           
                85                  90                  95                

gcg aga gag agg cat gga tat ttt gaa gct ttt gat atc tgg ggc caa        336
Ala Arg Glu Arg His Gly Tyr Phe Glu Ala Phe Asp Ile Trp Gly Gln           
            100                 105                 110                   

ggg acc acg gtc acc gtc tcc agt                                        360
Gly Thr Thr Val Thr Val Ser Ser                                           
        115                 120                                           


<210>  66
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  66

Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Asn Ser Tyr 
            20                  25                  30          


Ala Met Asp Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Asn Thr Gly Asn Pro Thr Tyr Ala Gln Ala Phe 
    50                  55                  60                  


Thr Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Glu Ile Ser Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Arg His Gly Tyr Phe Glu Ala Phe Asp Ile Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser 
        115                 120 


<210>  67
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MF5855


<220>
<221>  CDS
<222>  (1)..(360)

<400>  67
cag gtg cag ctg gtg caa tct ggg tct gag ttg aag aag cct ggg gcc         48
Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala           
1               5                   10                  15                

tca gtg aag gtt tcc tgc aag gct tct gga tac acc ttc act aag tat         96
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Lys Tyr           
            20                  25                  30                    

gtt atg aat tgg gtg cga cag gcc cct gga caa ggg ctt gag tgg atg        144
Val Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met           
        35                  40                  45                        

gga tgg atc aac acc aac act ggg aac cca acg tat gcc cag ggc ttc        192
Gly Trp Ile Asn Thr Asn Thr Gly Asn Pro Thr Tyr Ala Gln Gly Phe           
    50                  55                  60                            

aca gga cgg ttt gtc ttc tcc ttg gac acc tct gtc agc acg gca tat        240
Thr Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Ser Thr Ala Tyr           
65                  70                  75                  80            

ctg cag gtc agc agt cta agg gct gag gac act gcc ctg tat tac tgt        288
Leu Gln Val Ser Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys           
                85                  90                  95                

gcg aga gag tct aac tgg aac tac gac tac ttt gac tac tgg ggc cag        336
Ala Arg Glu Ser Asn Trp Asn Tyr Asp Tyr Phe Asp Tyr Trp Gly Gln           
            100                 105                 110                   

ggc acc ctg gtc acc gtc tcc agt                                        360
Gly Thr Leu Val Thr Val Ser Ser                                           
        115                 120                                           


<210>  68
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  68

Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Lys Tyr 
            20                  25                  30          


Val Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Asn Thr Gly Asn Pro Thr Tyr Ala Gln Gly Phe 
    50                  55                  60                  


Thr Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Val Ser Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Ser Asn Trp Asn Tyr Asp Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  69
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MF5862


<220>
<221>  CDS
<222>  (1)..(366)

<400>  69
cag gtg cag ctg gtg cag tct gga aca gag gtg aaa aag ccc ggg gag         48
Gln Val Gln Leu Val Gln Ser Gly Thr Glu Val Lys Lys Pro Gly Glu           
1               5                   10                  15                

tct ctg aag atc tcc tgt aag ggt tct gga tac agc ttt acc acc tac         96
Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Thr Tyr           
            20                  25                  30                    

tgg atc ggc tgg gtg cgc cag atg ccc ggg aaa ggc ctg gag tgg atg        144
Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met           
        35                  40                  45                        

gga atc atc tat cct ggt gac tct gat acc aga tac agc ccg tcc ttc        192
Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe           
    50                  55                  60                            

caa ggc cag gtc acc atc tca gcc gac aag tcc atc agc acc gcc tac        240
Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr           
65                  70                  75                  80            

ctg cag ttg agc agc ctg aag gcc tcg gac acc gcc atg tat tac tgt        288
Leu Gln Leu Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys           
                85                  90                  95                

gcg aga cgg ggt ctt agt atg gtt cgg ttg agc gct ttt gat gtc tgg        336
Ala Arg Arg Gly Leu Ser Met Val Arg Leu Ser Ala Phe Asp Val Trp           
            100                 105                 110                   

ggc caa gga acc ctg gtc acc gtc tcc agt                                366
Gly Gln Gly Thr Leu Val Thr Val Ser Ser                                   
        115                 120                                           


<210>  70
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  70

Gln Val Gln Leu Val Gln Ser Gly Thr Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Thr Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Leu Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Gly Leu Ser Met Val Arg Leu Ser Ala Phe Asp Val Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  71
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MF5882


<220>
<221>  CDS
<222>  (1)..(360)

<400>  71
cag gtg cag ctg gtg caa tct ggg tct gag ttg aag aag cct ggg gcc         48
Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala           
1               5                   10                  15                

tca gtg aag gtt tcc tgc aag gct tct gga tac acc ttc act aga tat         96
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Tyr           
            20                  25                  30                    

gct atg aat tgg gtg cga cag gcc cct gga caa ggg ctt gag tgg atg        144
Ala Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met           
        35                  40                  45                        

gga tgg atc aac acc aaa act ggg aac cca acg tat gcc cag ggc ttc        192
Gly Trp Ile Asn Thr Lys Thr Gly Asn Pro Thr Tyr Ala Gln Gly Phe           
    50                  55                  60                            

aca gga cgg ttt gtc ttc tcc ttg gac acc tct gtc agc acg gca tat        240
Thr Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Ser Thr Ala Tyr           
65                  70                  75                  80            

ctg cag atc agc agc cta aag gct gag gac act gcc gtg tat tac tgt        288
Leu Gln Ile Ser Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys           
                85                  90                  95                

gcg aga gat cgt ggg agc tac tat gat gct ttt gat atc tgg ggc caa        336
Ala Arg Asp Arg Gly Ser Tyr Tyr Asp Ala Phe Asp Ile Trp Gly Gln           
            100                 105                 110                   

ggg aca atg gtc acc gtc tcc agt                                        360
Gly Thr Met Val Thr Val Ser Ser                                           
        115                 120                                           


<210>  72
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  72

Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Lys Thr Gly Asn Pro Thr Tyr Ala Gln Gly Phe 
    50                  55                  60                  


Thr Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Ser Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Arg Gly Ser Tyr Tyr Asp Ala Phe Asp Ile Trp Gly Gln 
            100                 105                 110         


Gly Thr Met Val Thr Val Ser Ser 
        115                 120 


<210>  73
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MF5884


<220>
<221>  CDS
<222>  (1)..(360)

<400>  73
gag gtg cag ctg gtg cag tct ggg tct gaa ttg aag aag cct ggg gcc         48
Glu Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala           
1               5                   10                  15                

tca gtg aag gtt tcc tgc aag gct tct gga tac acc ttc act aag tat         96
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Lys Tyr           
            20                  25                  30                    

gct atg aat tgg gtg cga cag gtc cct gga caa ggg ctt gag tgg atg        144
Ala Met Asn Trp Val Arg Gln Val Pro Gly Gln Gly Leu Glu Trp Met           
        35                  40                  45                        

gga tgg atc aac acc aac act ggg aac cca acg tat gcc cag ggc ttc        192
Gly Trp Ile Asn Thr Asn Thr Gly Asn Pro Thr Tyr Ala Gln Gly Phe           
    50                  55                  60                            

aca gga cgg ttt gtc ttc tcc ttg gac acc tct gtc cgc acg gca tat        240
Thr Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Arg Thr Ala Tyr           
65                  70                  75                  80            

ctg cag atc agc agc cta aag gct gag gac act gcc gtg tat tac tgt        288
Leu Gln Ile Ser Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys           
                85                  90                  95                

gcg aga aaa ggg ggg agc tac tac gac tgg ttc gac ccc tgg ggc cag        336
Ala Arg Lys Gly Gly Ser Tyr Tyr Asp Trp Phe Asp Pro Trp Gly Gln           
            100                 105                 110                   

gga acc ctg gtc acc gtc tcc agt                                        360
Gly Thr Leu Val Thr Val Ser Ser                                           
        115                 120                                           


<210>  74
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  74

Glu Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Lys Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Val Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Asn Thr Gly Asn Pro Thr Tyr Ala Gln Gly Phe 
    50                  55                  60                  


Thr Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Arg Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Ser Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Lys Gly Gly Ser Tyr Tyr Asp Trp Phe Asp Pro Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  75
<211>  369
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MF5887


<220>
<221>  CDS
<222>  (1)..(369)

<400>  75
cag gtg cag ctg gtg cag tct ggg tct gag ttg aag aag cct ggg gcc         48
Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala           
1               5                   10                  15                

tca gtg aag gtt tcc tgc aag gct tct gga tac acc ttc act cgc tat         96
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Tyr           
            20                  25                  30                    

gct atg aat tgg gtg cga cag gcc cct gga caa ggg ctt gag tgg atg        144
Ala Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met           
        35                  40                  45                        

gga tgg atc aac acc aac act ggg aaa cca acg tat gcc cag ggc ttc        192
Gly Trp Ile Asn Thr Asn Thr Gly Lys Pro Thr Tyr Ala Gln Gly Phe           
    50                  55                  60                            

aca gga cgg ttt gtc ttc tcc ttg gac acc tct gtc agc acg gca tat        240
Thr Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Ser Thr Ala Tyr           
65                  70                  75                  80            

ctg cag atc agc agc ctg aag gct gag gac act gcc gtg tat tac tgt        288
Leu Gln Ile Ser Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys           
                85                  90                  95                

gcg aga gat aag ggc tat aac tgg aac tac atg ggt gct ttt gat atc        336
Ala Arg Asp Lys Gly Tyr Asn Trp Asn Tyr Met Gly Ala Phe Asp Ile           
            100                 105                 110                   

tgg ggc caa ggg acc acg gtc acc gtc tcc agt                            369
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser                               
        115                 120                                           


<210>  76
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  76

Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Asn Thr Gly Lys Pro Thr Tyr Ala Gln Gly Phe 
    50                  55                  60                  


Thr Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Ser Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Lys Gly Tyr Asn Trp Asn Tyr Met Gly Ala Phe Asp Ile 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  77
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MF5888


<220>
<221>  CDS
<222>  (1)..(360)

<400>  77
cag gtg cag ctg gtg cag tct ggg tct gag ttg aag aag ccc ggg ggc         48
Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Gly           
1               5                   10                  15                

tca atg aag gtt tcc tgc aag gct tct gga tac acc ttc act aga tat         96
Ser Met Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Tyr           
            20                  25                  30                    

gct atg aat tgg ttg cga cag gcc cct gga caa ggg ctt gag tgg atg        144
Ala Met Asn Trp Leu Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met           
        35                  40                  45                        

gga tgg atc aac acc aac act ggg aac cca acg tat gcc cag ggc ttc        192
Gly Trp Ile Asn Thr Asn Thr Gly Asn Pro Thr Tyr Ala Gln Gly Phe           
    50                  55                  60                            

aca gga cgg ttt gtc ttc tcc ttg gac acc tct gtc agc acg gca tat        240
Thr Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Ser Thr Ala Tyr           
65                  70                  75                  80            

ctg cag atc agc agc cta aag gct gag gac act gcc gtc tat tat tgt        288
Leu Gln Ile Ser Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys           
                85                  90                  95                

gcg aga cgg agt ggg agc tac tac gac tac ttt gac tac tgg ggc cag        336
Ala Arg Arg Ser Gly Ser Tyr Tyr Asp Tyr Phe Asp Tyr Trp Gly Gln           
            100                 105                 110                   

gga acc ctg gtc acc gtc tcc agt                                        360
Gly Thr Leu Val Thr Val Ser Ser                                           
        115                 120                                           


<210>  78
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  78

Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Gly 
1               5                   10                  15      


Ser Met Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Tyr 
            20                  25                  30          


Ala Met Asn Trp Leu Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Asn Thr Gly Asn Pro Thr Tyr Ala Gln Gly Phe 
    50                  55                  60                  


Thr Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Ser Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Ser Gly Ser Tyr Tyr Asp Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  79
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  common light chain - 1


<220>
<221>  CDS
<222>  (1)..(321)

<400>  79
gac atc cag atg acc cag tct cca tcc tcc ctg tct gca tct gta gga         48
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly           
1               5                   10                  15                

gac aga gtc acc atc act tgc cgg gca agt cag agc att agc agc tac         96
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr           
            20                  25                  30                    

tta aat tgg tat cag cag aaa cca ggg aaa gcc cct aag ctc ctg atc        144
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile           
        35                  40                  45                        

tat gct gca tcc agt ttg caa agt ggg gtc cca tca agg ttc agt ggc        192
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly           
    50                  55                  60                            

agt gga tct ggg aca gat ttc act ctc acc atc agc agt ctg caa cct        240
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro           
65                  70                  75                  80            

gaa gat ttt gca act tac tac tgt caa cag agt tac agt acc cct cca        288
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Pro           
                85                  90                  95                

acg ttc ggc caa ggg acc aag gtg gag atc aaa                            321
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys                               
            100                 105                                       


<210>  80
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  80

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Pro 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  81
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  common light chain - 2


<220>
<221>  CDS
<222>  (1)..(324)

<400>  81
cga act gtg gct gca cca tct gtc ttc atc ttc ccg cca tct gat gag         48
Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu           
1               5                   10                  15                

cag ttg aaa tct gga act gcc tct gtt gtg tgc ctg ctg aat aac ttc         96
Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe           
            20                  25                  30                    

tat ccc aga gag gcc aaa gta cag tgg aag gtg gat aac gcc ctc caa        144
Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln           
        35                  40                  45                        

tcg ggt aac tcc cag gag agt gtc aca gag cag gac agc aag gac agc        192
Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser           
    50                  55                  60                            

acc tac agc ctc agc agc acc ctg acg ctg agc aaa gca gac tac gag        240
Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu           
65                  70                  75                  80            

aaa cac aaa gtc tac gcc tgc gaa gtc acc cat cag ggc ctg agc tcg        288
Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser           
                85                  90                  95                

ccc gtc aca aag agc ttc aac agg gga gag tgt tag                        324
Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys                               
            100                 105                                       


<210>  82
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  82

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210>  83
<211>  294
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VH-CH1


<220>
<221>  CDS
<222>  (1)..(294)

<400>  83
gct agc acc aag ggc cca tcg gtc ttc ccc ctg gca ccc tcc tcc aag         48
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys           
1               5                   10                  15                

agc acc tct ggg ggc aca gcg gcc ctg ggc tgc ctg gtc aag gac tac         96
Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr           
            20                  25                  30                    

ttc ccc gaa ccg gtg acg gtg tcg tgg aac tca ggc gcc ctg acc agc        144
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser           
        35                  40                  45                        

ggc gtg cac acc ttc ccg gct gtc cta cag tcc tca gga ctc tac tcc        192
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser           
    50                  55                  60                            

ctc agc agc gtc gtg acc gtg ccc tcc agc agc ttg ggc acc cag acc        240
Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr           
65                  70                  75                  80            

tac atc tgc aac gtg aat cac aag ccc agc aac acc aag gtg gac aag        288
Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys           
                85                  90                  95                

aga gtt                                                                294
Arg Val                                                                   
                                                                          


<210>  84
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  84

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val 
        


<210>  85
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VH-hinge


<220>
<221>  CDS
<222>  (1)..(45)

<400>  85
gag ccc aaa tct tgt gac aaa act cac aca tgc cca ccg tgc cca             45
Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro               
1               5                   10                  15                


<210>  86
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  86

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15  


<210>  87
<211>  330
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VH-CH2


<220>
<221>  CDS
<222>  (1)..(330)

<400>  87
gca cct gaa ctc ctg ggg gga ccg tca gtc ttc ctc ttc ccc cca aaa         48
Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys           
1               5                   10                  15                

ccc aag gac acc ctc atg atc tcc cgg acc cct gag gtc aca tgc gtg         96
Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val           
            20                  25                  30                    

gtg gtg gac gtg agc cac gaa gac cct gag gtc aag ttc aac tgg tac        144
Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr           
        35                  40                  45                        

gtg gac ggc gtg gag gtg cat aat gcc aag aca aag ccg cgg gag gag        192
Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu           
    50                  55                  60                            

cag tac aac agc acg tac cgt gtg gtc agc gtc ctc acc gtc ctg cac        240
Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His           
65                  70                  75                  80            

cag gac tgg ctg aat ggc aag gag tac aag tgc aag gtc tcc aac aaa        288
Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys           
                85                  90                  95                

gcc ctc cca gcc ccc atc gag aaa acc atc tcc aaa gcc aaa                330
Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys                   
            100                 105                 110                   


<210>  88
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  88

Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
1               5                   10                  15      


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            20                  25                  30          


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        35                  40                  45              


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    50                  55                  60                  


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
65                  70                  75                  80  


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                85                  90                  95      


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
            100                 105                 110 


<210>  89
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VH-CH3


<220>
<221>  CDS
<222>  (1)..(321)

<400>  89
ggg cag ccc cga gaa cca cag gtg tac acc aag ccc cca tcc cgg gag         48
Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Lys Pro Pro Ser Arg Glu           
1               5                   10                  15                

gag atg acc aag aac cag gtc agc ctg aag tgc ctg gtc aaa ggc ttc         96
Glu Met Thr Lys Asn Gln Val Ser Leu Lys Cys Leu Val Lys Gly Phe           
            20                  25                  30                    

tat ccc agc gac atc gcc gtg gag tgg gag agc aat ggg cag ccg gag        144
Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu           
        35                  40                  45                        

aac aac tac aag acc acg cct ccc gtg ctg gac tcc gac ggc tcc ttc        192
Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe           
    50                  55                  60                            

ttc ctc tat agc aag ctc acc gtg gac aag agc agg tgg cag cag ggg        240
Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly           
65                  70                  75                  80            

aac gtc ttc tca tgc tcc gtg atg cat gag gct ctg cac aac cac tac        288
Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr           
                85                  90                  95                

acg cag aag agc ctc tcc ctg tct ccg ggt tga                            321
Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly                                   
            100                 105                                       


<210>  90
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  90

Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Lys Pro Pro Ser Arg Glu 
1               5                   10                  15      


Glu Met Thr Lys Asn Gln Val Ser Leu Lys Cys Leu Val Lys Gly Phe 
            20                  25                  30          


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
        35                  40                  45              


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
    50                  55                  60                  


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
65                  70                  75                  80  


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
                85                  90                  95      


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
            100                 105     


<210>  91
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VH-CH3


<220>
<221>  CDS
<222>  (1)..(321)

<400>  91
ggg cag ccc cga gaa cca cag gtg tac acc gac ccc cca tcc cgg gag         48
Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Asp Pro Pro Ser Arg Glu           
1               5                   10                  15                

gag atg acc aag aac cag gtc agc ctg acc tgc gag gtc aaa ggc ttc         96
Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Glu Val Lys Gly Phe           
            20                  25                  30                    

tat ccc agc gac atc gcc gtg gag tgg gag agc aat ggg cag ccg gag        144
Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu           
        35                  40                  45                        

aac aac tac aag acc acg cct ccc gtg ctg gac tcc gac ggc tcc ttc        192
Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe           
    50                  55                  60                            

ttc ctc tat agc aag ctc acc gtg gac aag agc agg tgg cag cag ggg        240
Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly           
65                  70                  75                  80            

aac gtc ttc tca tgc tcc gtg atg cat gag gct ctg cac aac cac tac        288
Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr           
                85                  90                  95                

acg cag aag agc ctc tcc ctg tct ccg ggt tga                            321
Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly                                   
            100                 105                                       


<210>  92
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  92

Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Asp Pro Pro Ser Arg Glu 
1               5                   10                  15      


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Glu Val Lys Gly Phe 
            20                  25                  30          


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
        35                  40                  45              


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
    50                  55                  60                  


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
65                  70                  75                  80  


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
                85                  90                  95      


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
            100                 105     


<210>  93
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH1-69 J00256-AEHJ2

<400>  93

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Lys 
    50                  55                  60                  


Phe Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala 
65                  70                  75                  80  


Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser 
            100                 105                 110 


<210>  94
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  member of supercluster 1

<400>  94

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Phe Gly Gly Thr Phe Asn Asn Tyr 
            20                  25                  30          


Ala Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ser Ile Ile Pro Ile Leu Gly Thr Val Asp His Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Asn Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu His Ile Ala Ala Arg Leu Asp Tyr Phe Asp Tyr Trp Asp 
            100                 105                 110         


Leu Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  95
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  member of supercluster 1

<400>  95

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Ser Thr Asn Asp 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Thr Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ser Ile Ile Pro Ile Leu Asp Thr Thr Asp His Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Asn Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu His Ile Ala Ala Arg Gln Asp Tyr Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  96
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  member of supercluster 1

<400>  96

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Arg Ala Ser Gly Asp Ser Val Ser Asn Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ser Ile Ile Pro Ile Leu Gly Thr Thr Asp His Ala Gln Gln Phe 
    50                  55                  60                  


Gln Asp Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Gly Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Arg Ile Ala Ala Arg Gln Asp Tyr Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  97
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  member of supercluster 1

<400>  97

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Asn Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ser Ile Ile Pro Ile Leu Gly Thr Thr Asp His Ala Gln Lys Phe 
    50                  55                  60                  


Gln Asp Arg Val Thr Ile Thr Ala Asp Arg Ser Ser Asn Thr Thr Tyr 
65                  70                  75                  80  


Met Asp Leu Asn Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Leu Ile Ala Ala Arg Leu Asp Tyr Phe Asp Ser Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  98
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  member of supercluster 1

<400>  98

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Asn Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ser Ile Ile Pro Ile Leu Gly Thr Thr Asp His Ala Gln Lys Phe 
    50                  55                  60                  


Gln Asp Arg Val Thr Ile Thr Ala Asp Lys Ser Ser Asn Thr Thr Tyr 
65                  70                  75                  80  


Met Asp Leu Ser Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Arg Ile Ala Ala Arg Leu Asp Tyr Phe Asp Ser Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  99
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  member of supercluster 1

<400>  99

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ser Ser Gly Gly Thr Phe Lys Asn Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ser Ile Ile Pro Ile Leu Gly Thr Thr Asp His Ala Gln Asn Phe 
    50                  55                  60                  


Gln Asp Arg Val Thr Ile Thr Ala Asp Lys Leu Ser Asn Thr Thr Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ile Glu Leu Ile Ala Ala Arg Leu Asp Tyr Phe His Ser Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  100
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  member of supercluster 1

<400>  100

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Val Ser Asn Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Asp Trp Met 
        35                  40                  45              


Gly Ser Ile Ile Pro Ile Leu Gly Thr Thr Asp His Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Phe Thr Ala Asp Lys Ser Thr Asn Thr Ser Tyr 
65                  70                  75                  80  


Met Glu Leu Asn Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Leu Ile Ala Ala Arg Gln Asp Tyr Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  101
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  member of supercluster 1

<400>  101

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Asn Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ser Ile Ile Pro Ile Leu Gly Thr Thr Asp His Ala Gln Lys Phe 
    50                  55                  60                  


Gln Asp Arg Val Thr Ile Thr Ala Asp Arg Ser Ser Asn Thr Thr Tyr 
65                  70                  75                  80  


Met Asp Leu Asn Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Leu Ile Ala Ala Arg Leu Asp Tyr Phe Asp Ser Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  102
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  member of supercluster 1

<400>  102

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Ser Thr Asn Asp 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Thr Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ser Ile Ile Pro Ile Leu Asp Thr Thr Asp His Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Asn Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu His Ile Ala Ala Arg Gln Asp Tyr Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  103
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  member of supercluster 1

<400>  103

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ser Ser Gly Gly Thr Phe Lys Asn Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ser Ile Ile Pro Ile Leu Gly Thr Thr Asp His Ala Gln Asn Phe 
    50                  55                  60                  


Gln Asp Arg Val Thr Ile Thr Ala Asp Lys Leu Ser Asn Thr Thr Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ile Glu Leu Ile Ala Ala Arg Leu Asp Tyr Phe His Ser Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  104
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  member of supercluster 1

<400>  104

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Ser Thr Asn Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Thr Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ser Ile Ile Pro Ile Leu Asp Thr Thr Asp His Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Asn Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu His Ile Ala Ala Arg Gln Asp Tyr Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  105
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  member of supercluster 1

<400>  105

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Ser Thr Asn Asp 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Thr Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ser Ile Ile Pro Ile Leu Asp Thr Thr Asp His Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Arg Ser Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Asn Ser Leu Lys Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu His Ile Ala Ala Arg Gln Asp Tyr Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  106
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  member of supercluster 1

<400>  106

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Leu Ser Asn Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ser Ile Ile Pro Ile Leu Gly Thr Thr Asp His Ala Gln Asn Phe 
    50                  55                  60                  


Gln Asp Arg Val Thr Ile Thr Ala Asp Lys Ser Ser Asn Thr Thr Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Arg Ile Ala Ala Arg Leu Asp Tyr Phe Asp Ser Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  107
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  member of supercluster 1

<400>  107

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Leu Ser Asn Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ser Ile Ile Pro Ile Leu Gly Thr Ile Asp His Ala Gln Asn Phe 
    50                  55                  60                  


Gln Asp Arg Val Thr Ile Thr Ala Asp Lys Ser Ser Asn Thr Thr Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Arg Ile Ala Ala Arg Leu Asp Tyr Phe Asp Ser Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  108
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  member of supercluster 1

<400>  108

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Arg Ala Ser Gly Asp Ser Val Ser Asn Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ser Ile Ile Pro Ile Leu Gly Thr Thr Asp His Ala Gln Gln Phe 
    50                  55                  60                  


Gln Asp Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Gly Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Arg Ile Ala Ala Arg Gln Asp Tyr Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  109
<211>  128
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  member of supercluster 1

<400>  109

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Asn Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ser Ile Ile Pro Ile Leu Gly Thr Thr Asp His Ala Glu Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Asp Leu Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Asp 
                85                  90                  95      


Asp Thr Ala Val Tyr Tyr Cys Ala Arg Glu Phe Ile Ala Ala Arg Gln 
            100                 105                 110         


Asp Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125             


<210>  110
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  member of supercluster 1

<400>  110

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Asn Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ser Ile Ile Pro Ile Leu Gly Thr Thr Asp His Ala Gln Lys Phe 
    50                  55                  60                  


Gln Asp Arg Val Thr Ile Thr Ala Asp Lys Ser Ser Asn Thr Thr Tyr 
65                  70                  75                  80  


Met Asp Leu Ser Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Arg Ile Ala Ala Arg Leu Asp Tyr Phe Asp Ser Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  111
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  member of supercluster 1

<400>  111

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Ser Thr Asn Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Thr Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ser Ile Ile Pro Ile Leu Asp Thr Thr Asp His Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Asn Thr Thr Tyr 
65                  70                  75                  80  


Met Glu Leu Asn Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu His Ile Ala Ala Arg Leu Asp Tyr Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  112
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  member of supercluster 1

<400>  112

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Phe Gly Gly Thr Phe Asn Asn Tyr 
            20                  25                  30          


Ala Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ser Ile Ile Pro Ile Leu Gly Thr Val Asp His Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Asn Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu His Ile Ala Ala Arg Leu Asp Tyr Phe Asp Tyr Trp Asp 
            100                 105                 110         


Leu Gly Ile Leu Val Thr Val Ser Ser 
        115                 120     


<210>  113
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  member of supercluster 1

<400>  113

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Asn Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ser Ile Ile Pro Ile Leu Gly Thr Thr Asp His Ala Gln Asn Phe 
    50                  55                  60                  


Gln Asp Arg Val Thr Ile Thr Ala Asp Lys Ser Ser Asn Thr Thr Tyr 
65                  70                  75                  80  


Met Glu Leu Ile Gly Leu Lys Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Arg Ile Ala Ala Arg Leu Asp Tyr Phe Asp Ser Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  114
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  member of supercluster 1

<400>  114

Arg Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Phe Gly Gly Thr Phe Asn Asn Tyr 
            20                  25                  30          


Ala Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ser Ile Ile Pro Ile Leu Gly Thr Val Asp His Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Ser Asn Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu His Ile Ala Ala Arg Leu Asp Tyr Phe Asp Ser Trp Gly 
            100                 105                 110         


Leu Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  115
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  member of supercluster 1

<400>  115

Arg Cys Ser Met Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Arg Ala Ser Gly Asp Ser Val Ser Asn Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ser Ile Ile Pro Ile Leu Gly Thr Thr Asp His Ala Gln Gln Phe 
    50                  55                  60                  


Gln Asp Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Gly Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Arg Ile Ala Ala Arg Gln Asp Tyr Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  116
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  member of supercluster 1

<400>  116

Arg Cys Ser Met Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Asn Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ser Ile Ile Pro Ile Leu Gly Thr Thr Asp His Ala Gln Lys Phe 
    50                  55                  60                  


Gln Asp Arg Val Thr Ile Thr Ala Asp Arg Ser Ser Asn Thr Thr Tyr 
65                  70                  75                  80  


Met Asp Leu Asn Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Leu Ile Ala Ala Arg Leu Asp Tyr Phe Asp Ser Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  117
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  member of supercluster 1

<400>  117

Glu Val Gln Leu Val Gln Ser Gly Thr Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Asn Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ser Ile Ile Pro Ile Leu Gly Thr Thr Asp His Thr Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Ile Thr Ile Thr Ala Asp Lys Ser Thr Asn Thr Ser Tyr 
65                  70                  75                  80  


Met Asp Leu Asn Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Arg Ile Ala Ala Arg Gln Asp Tyr Phe Asp Ser Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  118
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  member of supercluster 1

<400>  118

Arg Leu Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Ser Thr Asn Asp 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ser Ile Ile Pro Ile Leu Gly Thr Thr Asp His Ala Gln Asn Phe 
    50                  55                  60                  


Gln Asp Arg Val Thr Ile Thr Ala Asp Lys Ser Ser Asn Thr Thr Tyr 
65                  70                  75                  80  


Met Glu Leu Ile Gly Leu Lys Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Arg Ile Ala Ala Arg Leu Asp Tyr Phe Asp Ser Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  119
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  member of supercluster 1

<400>  119

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Ser Thr Asn Asp 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Thr Pro Glu Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ser Ile Ile Pro Ile Leu Asp Thr Thr Asp His Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Arg Ser Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Asn Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Leu Ile Ala Ala Arg Leu Asp Tyr Phe Asp Ser Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  120
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  member of supercluster 1

<400>  120

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Thr Asn Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ser Ile Ile Pro Ile Leu Gly Thr Thr Asp His Ala Gln Asn Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Arg Ser Ala Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Asn Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu His Ile Ala Ala Arg Gln Asp Tyr Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Glu Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  121
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  member of supercluster 1

<400>  121

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ser Ile Ile Pro Ile Leu Gly Thr Thr Asp His Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Ile Ser Thr Ile Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Asp Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Arg Ile Ala Ala Arg Gln Asp Tyr Phe Asp Phe Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  122
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  member of supercluster 1

<400>  122

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Asn Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ser Ile Ile Pro Ile Leu Gly Thr Thr Asp His Ala Gln Lys Phe 
    50                  55                  60                  


Gln Asp Arg Val Thr Ile Thr Ala Gly Lys Ser Ser Asn Thr Thr Tyr 
65                  70                  75                  80  


Met Asp Leu Ser Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Arg Ile Ala Ala Arg Leu Asp Tyr Phe Asp Ser Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  123
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  member of supercluster 1

<400>  123

Gln Val Gln Leu Val Gln Ser Gly Ala Ala Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Ser Thr Asn Asp 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Thr Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ser Ile Ile Pro Ile Leu Asp Thr Thr Asp His Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Asn Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu His Ile Ala Ala Arg Gln Asp Tyr Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  124
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  member of supercluster 1

<400>  124

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Ser Thr Asn Asp 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Thr Pro Glu Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ser Ile Ile Pro Ile Leu Gly Thr Val Asp His Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Asn Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu His Ile Ala Ala Arg Leu Asp Tyr Phe Asp Tyr Trp Asp 
            100                 105                 110         


Leu Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  125
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  member of supercluster 1

<400>  125

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Asp Thr Ser Thr Asn Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Thr Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ser Ile Ile Pro Ile Leu Gly Thr Thr Asp His Thr Gln Lys Phe 
    50                  55                  60                  


Gln Asp Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Asn Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu His Ile Ala Ser Arg Gln Asp Phe Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  126
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  member of supercluster 1

<400>  126

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Asn Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ser Ile Ile Pro Ile Leu Gly Thr Thr Asp His Ala Gln Lys Phe 
    50                  55                  60                  


Gln Asp Arg Val Thr Ile Thr Ala Asp Lys Ser Ser Asn Thr Thr Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Arg Ile Ala Ala Arg Leu Asp Tyr Phe Asp Ser Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  127
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  member of supercluster 1

<400>  127

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Asn Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ser Ile Ile Pro Ile Leu Gly Thr Thr Asp His Ala Gln Lys Phe 
    50                  55                  60                  


Gln Asp Arg Val Thr Ile Thr Ala Asp Lys Ser Ser Asn Thr Thr Tyr 
65                  70                  75                  80  


Met Asp Leu Ser Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Arg Ile Ala Ala Arg Leu Asp Tyr Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  128
<211>  128
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  member of supercluster 1

<400>  128

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Asn Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ser Ile Ile Pro Ile Leu Gly Thr Thr Asp His Ala Glu Lys Phe 
    50                  55                  60                  


Gln Gly Lys Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Asp Leu Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Asp 
                85                  90                  95      


Asp Thr Ala Val Tyr Tyr Cys Ala Arg Glu Phe Ile Ala Ala Arg Gln 
            100                 105                 110         


Asp Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125             


<210>  129
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  member of supercluster 1

<400>  129

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Asn Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ser Ile Ile Pro Ile Phe Gly Thr Ala Asp Asn Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Arg Ile Ala Ala Arg Gln Asp Tyr Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  130
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  member of supercluster 1

<400>  130

Glu Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Ser Thr Asn Asp 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Thr Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ser Ile Ile Pro Ile Leu Asp Thr Thr Asp His Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Arg Ser Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Asn Ser Leu Lys Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu His Ile Ala Ala Arg Gln Asp Tyr Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  131
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  member of supercluster 1

<400>  131

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Ser Thr Asn Asp 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Thr Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ser Ile Ile Pro Ile Leu Asp Thr Thr Asp His Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Arg Ser Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Asn Ser Leu Lys Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu His Ile Ala Ala Arg Gln Asp Tyr Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  132
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  member of supercluster 1

<400>  132

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Leu Ser Asn Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ser Ile Ile Pro Ile Leu Gly Thr Thr Asp His Ala Gln Asn Phe 
    50                  55                  60                  


Gln Asp Arg Val Thr Ile Thr Ala Asp Lys Ser Ser Asn Thr Thr Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Arg Ile Ala Ala Arg Leu Asp Tyr Phe Asp Ser Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  133
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  member of supercluster 1

<400>  133

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Met Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Ser Thr Asn Asp 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Thr Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ser Ile Ile Pro Ile Leu Asp Thr Thr Asp His Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Arg Ser Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Asn Ser Leu Lys Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu His Ile Ala Ala Arg Gln Asp Tyr Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  134
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  member of supercluster 1

<400>  134

Arg Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Tyr 
            20                  25                  30          


Ala Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ser Ile Ile Pro Ile Leu Gly Thr Val Asp His Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Asn Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu His Ile Ala Ala Arg Leu Asp Tyr Phe Asp Tyr Trp Asp 
            100                 105                 110         


Leu Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  135
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  member of supercluster 1

<400>  135

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ser Ile Ile Pro Ile Leu Gly Thr Thr Asp His Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Phe Thr Ala Asp Lys Ser Thr Asn Thr Ser Tyr 
65                  70                  75                  80  


Met Glu Leu Asn Ser Leu Arg Ser Asp Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Arg Ile Ala Ala Arg Gln Asp Tyr Phe Asp Ser Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  136
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  member of supercluster 1

<400>  136

Arg Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Asn Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ser Ile Ile Pro Ile Leu Gly Thr Thr Asp His Ala Gln Lys Phe 
    50                  55                  60                  


Gln Asp Arg Val Thr Ile Thr Ala Asp Lys Ser Ser Asn Thr Thr Tyr 
65                  70                  75                  80  


Met Asp Leu Ser Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Arg Ile Ala Ala Arg Leu Asp Tyr Phe Asp Ser Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  137
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  member of supercluster 1

<400>  137

Arg Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Phe Gly Gly Thr Phe Asn Asn Tyr 
            20                  25                  30          


Ala Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ser Ile Ile Pro Ile Leu Gly Thr Val Asp His Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Asn Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu His Ile Ala Ala Arg Leu Asp Tyr Phe Asp Tyr Trp Asp 
            100                 105                 110         


Leu Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  138
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  member of supercluster 1

<400>  138

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Leu Ser Asn Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ser Ile Ile Pro Ile Leu Gly Thr Ala Asp His Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Arg Ile Ala Ala Arg Gln Asp Tyr Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  139
<211>  128
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  member of supercluster 1

<400>  139

Glu Val Gln Leu Val Gln Ser Gly Thr Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Asn Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ser Ile Ile Pro Ile Leu Gly Thr Thr Asp His Ala Glu Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Asp Leu Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Asp 
                85                  90                  95      


Asp Thr Ala Val Tyr Tyr Cys Ala Arg Glu Phe Ile Ala Ala Arg Gln 
            100                 105                 110         


Asp Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125             


<210>  140
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  member of supercluster 1

<400>  140

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ser Ile Ile Pro Ile Leu Gly Thr Val Asp His Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Asn Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu His Ile Ala Ala Arg Leu Asp Tyr Phe Asp Tyr Trp Asp 
            100                 105                 110         


Leu Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  141
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  member of supercluster 1

<400>  141

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Glu Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Asn Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ser Ile Ile Pro Ile Leu Gly Thr Thr Asp His Ala Gln Lys Phe 
    50                  55                  60                  


Gln Asp Arg Val Thr Ile Thr Ala Asp Lys Ser Ser Asn Thr Thr Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu His Ile Ala Ala Arg Leu Asp Tyr Phe Asp Ser Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  142
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  member of supercluster 1

<400>  142

Glu Val Gln Leu Val Gln Ser Gly Thr Glu Val Arg Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Asn Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ser Ile Ile Pro Ile Leu Gly Thr Thr Asp His Ala Gln Lys Phe 
    50                  55                  60                  


Gln Asp Arg Val Thr Ile Thr Ala Asp Lys Ser Ser Asn Thr Thr Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Tyr Ile Ala Ala Arg Leu Asp Tyr Phe Asp Ser Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  143
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  member of supercluster 1

<400>  143

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Asn Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ser Ile Ile Pro Ile Leu Gly Thr Thr Asp His Ala Glu Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Phe Ile Ala Ala Arg Gln Asp Tyr Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  144
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  member of supercluster 1

<400>  144

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ser Ser Gly Gly Thr Phe Lys Asn Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ser Ile Ile Pro Ile Leu Gly Thr Thr Asp His Ala Gln Asn Phe 
    50                  55                  60                  


Gln Asp Arg Val Thr Ile Thr Ala Asp Lys Leu Ser Asn Thr Thr Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Arg Ile Ala Ala Arg Leu Asp Tyr Phe Asp Ser Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  145
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  member of supercluster 1

<400>  145

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Glu Ala Ser Gly Gly Thr Phe Thr Asn Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ser Ile Ile Pro Val Leu Gly Thr Thr Asp His Ala Gln Lys Phe 
    50                  55                  60                  


Gln Asp Arg Val Thr Ile Thr Ala Asp Lys Ser Ser Asn Ile Thr Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Arg Ile Ala Ala Arg Leu Asp Tyr Phe Asp Ser Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  146
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  member of supercluster 1

<400>  146

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Ser Thr Asn Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Thr Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ser Ile Ile Pro Ile Leu Asp Thr Thr Asp His Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Asn Thr Thr Tyr 
65                  70                  75                  80  


Met Glu Leu Asn Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu His Ile Ala Ala Arg Leu Asp Tyr Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  147
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  member of supercluster 1

<400>  147

Glu Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Asn Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ser Ile Ile Pro Ile Leu Gly Thr Thr Asp His Ala Gln Lys Phe 
    50                  55                  60                  


Gln Asp Arg Val Thr Ile Thr Ala Asp Lys Ser Ser Asn Thr Thr Tyr 
65                  70                  75                  80  


Met Asp Leu Ser Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Arg Ile Ala Ala Arg Leu Asp Tyr Phe Asp Ser Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  148
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  member of supercluster 1

<400>  148

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Asn Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ser Ile Ile Pro Ile Leu Gly Thr Thr Asp His Val Glu Lys Phe 
    50                  55                  60                  


Gln Asp Arg Val Thr Ile Thr Ala Asp Lys Ser Ser Asn Thr Thr Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Leu Ile Ala Ala Arg Leu Asp Tyr Phe Asp Ser Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  149
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  member of supercluster 1

<400>  149

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Asn Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ser Ile Ile Pro Ile Leu Gly Thr Thr Asp His Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Phe Thr Ala Asp Lys Ser Thr Asn Thr Ser Tyr 
65                  70                  75                  80  


Met Glu Leu Asn Ser Leu Arg Ser Asp Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Arg Ile Ala Ala Arg Gln Asp Tyr Phe Asp Ser Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  150
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  member of supercluster 1

<400>  150

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Ser Thr Asn Asp 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Thr Pro Glu Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ser Ile Ile Pro Ile Leu Asp Thr Thr Asp His Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Arg Ser Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Asn Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu His Ile Ala Ala Arg Gln Asp Tyr Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  151
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  member of supercluster 1

<400>  151

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ser Ile Ile Pro Ile Leu Asp Thr Thr Asp His Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Asn Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu His Ile Ala Ala Arg Gln Asp Tyr Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  152
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  member of supercluster 1

<400>  152

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Asn Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ser Ile Ile Pro Ile Leu Gly Thr Thr Asp His Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Phe Thr Ala Asp Lys Ser Thr Asn Thr Ser Tyr 
65                  70                  75                  80  


Met Glu Leu Asn Ser Leu Arg Ser Asp Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Arg Ile Ala Ala Arg Gln Asp Tyr Phe Asp Ser Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  153
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  member of supercluster 1

<400>  153

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Asn Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ser Ile Ile Pro Ile Leu Gly Thr Thr Asp His Ala Gln Lys Phe 
    50                  55                  60                  


Gln Asp Arg Val Thr Ile Thr Ala Asp Lys Ser Ser Lys Thr Thr Tyr 
65                  70                  75                  80  


Met Glu Leu Asn Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Leu Ile Ala Ala Arg Leu Asp Tyr Phe Asp Ser Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  154
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  member of supercluster 1

<400>  154

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Thr Pro Glu Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ser Ile Ile Pro Ile Leu Asp Thr Thr Asp His Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Arg Ser Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Asn Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu His Ile Ala Ala Arg Gln Asp Tyr Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  155
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  member of supercluster 1

<400>  155

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Asn Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ser Ile Ile Pro Ile Leu Gly Thr Thr Asp His Ala Gln Lys Phe 
    50                  55                  60                  


Gln Asp Arg Val Thr Ile Thr Ala Asp Lys Ser Ser Asn Thr Thr Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu His Ile Ala Ala Arg Leu Asp Tyr Phe Asp Ser Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  156
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  member of supercluster 1

<400>  156

Arg Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Arg Ala Ser Gly Asp Ser Val Ser Asn Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ser Ile Ile Pro Ile Leu Gly Thr Thr Asp His Ala Gln Gln Phe 
    50                  55                  60                  


Gln Asp Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Gly Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Arg Ile Ala Ala Arg Gln Asp Tyr Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  157
<211>  99
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH4-39|J00256-AEHJ6

<400>  157

Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Ser 
            20                  25                  30          


Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Ser Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg 
            


<210>  158
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  member of supercluster 8

<400>  158

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Phe Ser Ser Ser 
            20                  25                  30          


Ser Ser Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Ser Phe Tyr Tyr Ser Gly Asn Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Glu Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Gln Thr Tyr Ser Ser Ser Trp Asp Gly Val Leu Tyr Tyr 
            100                 105                 110         


Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     


<210>  159
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  member of supercluster 8

<400>  159

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Phe Ser Ser Ser 
            20                  25                  30          


Ser Ser Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Ser Phe Tyr Tyr Ser Gly Asn Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Gln Thr Tyr Ser Ser Ser Trp Asp Gly Val Leu Tyr Tyr 
            100                 105                 110         


Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     


<210>  160
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  member of supercluster 8

<400>  160

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Ser 
            20                  25                  30          


Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ser Phe Tyr Tyr Ser Gly Asn Thr Tyr Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Glu Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Gln Thr Tyr Ser Ser Ser Trp Asp Gly Val Leu Tyr Tyr Phe Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  161
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  member of supercluster10

<400>  161

Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Asn Thr Gly Asn Pro Thr Tyr Ala Gln Gly Phe 
    50                  55                  60                  


Thr Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Ser Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
            100                 105                 


<210>  162
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  member of supercluster10

<400>  162

Glu Val Gln Leu Val Gln Ser Gly Ser Lys Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Thr Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Asp Thr Gly Asp Pro Thr Tyr Ala Gln Gly Phe 
    50                  55                  60                  


Thr Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Ser Thr Ala Phe 
65                  70                  75                  80  


Leu Gln Ile Asn Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Asp Cys Asp Ser Thr Ser Cys Tyr Arg Tyr Ser Tyr Gly 
            100                 105                 110         


Tyr Glu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125         


<210>  163
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  member of supercluster10

<400>  163

Glu Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Asp Thr Gly Asp Pro Thr Tyr Ala Gln Gly Phe 
    50                  55                  60                  


Thr Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Ser Thr Ala Phe 
65                  70                  75                  80  


Leu Gln Ile Asn Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Asp Cys Asp Ser Thr Ser Cys Tyr Arg Tyr Ser Tyr Gly 
            100                 105                 110         


Tyr Glu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125         


<210>  164
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  member of supercluster10

<400>  164

Glu Val Gln Leu Val Gln Ser Gly Ser Ala Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Thr Met Asn Trp Val Arg Ala Gln Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Gln Thr Gly Asn Pro Thr Tyr Ala Gln Gly Phe 
    50                  55                  60                  


Thr Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Ser Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Asp Cys Ser Ser Thr Ser Cys Tyr Arg Tyr Ser Tyr Gly 
            100                 105                 110         


Tyr Glu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125         


<210>  165
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  member of supercluster10

<400>  165

Glu Val Gln Leu Val Gln Ser Gly Ser Thr Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Thr Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asp Thr Asn Thr Gly Asp Pro Thr Tyr Ala Gln Gly Phe 
    50                  55                  60                  


Thr Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Thr Thr Ala Phe 
65                  70                  75                  80  


Leu Gln Ile Asn Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Asp Cys Asp Ser Thr Ser Cys Tyr Arg Tyr Ser Tyr Gly 
            100                 105                 110         


Tyr Glu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125         


<210>  166
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  member of supercluster10

<400>  166

Gly Cys Ser Met Val Gln Ser Gly Ser Glu Ser Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Asn Thr Gly Asn Pro Thr Tyr Ala Gln Gly Phe 
    50                  55                  60                  


Thr Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Ser Thr Ala Phe 
65                  70                  75                  80  


Leu Gln Ile Asn Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Asp Cys Asp Ser Thr Ser Cys Tyr Arg Tyr Ser Tyr Gly 
            100                 105                 110         


Tyr Glu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125         


<210>  167
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  member of supercluster10

<400>  167

Glu Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Asn Thr Gly Asn Pro Thr Tyr Ala Gln Gly Phe 
    50                  55                  60                  


Thr Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Thr Thr Ala Phe 
65                  70                  75                  80  


Leu Gln Ile Asn Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Asp Cys Asp Ser Thr Ser Cys Tyr Arg Tyr Ser Tyr Gly 
            100                 105                 110         


Tyr Glu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125         


<210>  168
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  member of supercluster10

<400>  168

Glu Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Asn Thr Gly Asn Pro Thr Tyr Ala Gln Gly Phe 
    50                  55                  60                  


Thr Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Ser Thr Ala Phe 
65                  70                  75                  80  


Leu Gln Ile Asn Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Asp Cys Asp Ser Thr Ser Cys Tyr Arg Tyr Ser Tyr Gly 
            100                 105                 110         


Tyr Glu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125         


<210>  169
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  member of supercluster10

<400>  169

Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Asp Pro Thr Tyr Ala Gln Gly Phe 
    50                  55                  60                  


Thr Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Asn Asn Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Asp Cys Ser Ser Thr Ser Cys Tyr Arg Tyr Ser Tyr Gly 
            100                 105                 110         


Tyr Glu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125         


<210>  170
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  member of supercluster10

<400>  170

Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Asp Thr Gly Asp Pro Thr Tyr Ala Gln Gly Phe 
    50                  55                  60                  


Thr Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Ser Thr Ala Phe 
65                  70                  75                  80  


Leu Gln Ile Asn Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Asp Cys Asp Ser Thr Ser Cys Tyr Arg Tyr Ser Tyr Gly 
            100                 105                 110         


Tyr Glu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125         


<210>  171
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  member of supercluster10

<400>  171

Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Thr Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asp Thr Asn Thr Gly Asp Pro Thr Tyr Ala Gln Gly Phe 
    50                  55                  60                  


Thr Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Thr Thr Ala Phe 
65                  70                  75                  80  


Leu Gln Ile Asn Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Asp Cys Asp Ser Thr Ser Cys Tyr Arg Tyr Ser Tyr Gly 
            100                 105                 110         


Tyr Glu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125         


<210>  172
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  member of supercluster10

<400>  172

Glu Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Ala Leu Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Asn Thr Gly Asp Pro Thr Tyr Ala Gln Gly Phe 
    50                  55                  60                  


Thr Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Ser Ser Ala Phe 
65                  70                  75                  80  


Leu Gln Ile Ser Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Asp Cys Asp Ser Thr Asp Cys Tyr Arg Tyr Ser Tyr Gly 
            100                 105                 110         


Tyr Glu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125         


<210>  173
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  member of supercluster10

<400>  173

Glu Val Gln Leu Val Gln Ser Gly Ser Lys Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Thr Met Asn Trp Val Arg Gln Ala Pro Gly Arg Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Asn Thr Gly Asp Pro Thr Tyr Ala Gln Gly Phe 
    50                  55                  60                  


Thr Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Ser Thr Ala Phe 
65                  70                  75                  80  


Leu Gln Ile Asn Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Asp Cys Asp Ser Thr Ser Cys Tyr Arg Tyr Ser Tyr Gly 
            100                 105                 110         


Tyr Glu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125         


<210>  174
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  member of supercluster10

<400>  174

Glu Val Gln Leu Val Gln Ser Gly Ser Lys Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Thr Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Asp Thr Gly Asp Pro Thr Tyr Ala Gln Gly Phe 
    50                  55                  60                  


Thr Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Ser Thr Ala Phe 
65                  70                  75                  80  


Leu Gln Ile Asn Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Asp Cys Asp Ser Thr Ser Cys Tyr Arg Tyr Ser Tyr Gly 
            100                 105                 110         


Tyr Glu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125         


<210>  175
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  member of supercluster10

<400>  175

Glu Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Thr Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Asp Thr Gly Asp Pro Thr Tyr Ala Gln Gly Phe 
    50                  55                  60                  


Thr Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Ser Thr Ala Phe 
65                  70                  75                  80  


Leu Gln Ile Asn Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Asp Cys Asp Ser Thr Ser Cys Tyr Arg Tyr Ser Tyr Gly 
            100                 105                 110         


Tyr Glu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125         


<210>  176
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  member of supercluster10

<400>  176

Glu Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Asp Pro Thr Tyr Ala Gln Gly Phe 
    50                  55                  60                  


Thr Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Asn Asn Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Asp Cys Ser Ser Thr Ser Cys Tyr Arg Tyr Ser Tyr Gly 
            100                 105                 110         


Tyr Glu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125         


<210>  177
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  member of supercluster10

<400>  177

Glu Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asp Thr Asn Thr Gly Asn Pro Thr Tyr Ala Gln Gly Phe 
    50                  55                  60                  


Thr Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Ser Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Asp Cys Ser Ser Thr Ser Cys Tyr Arg Tyr Ser Tyr Gly 
            100                 105                 110         


Tyr Glu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125         


<210>  178
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  member of supercluster10

<400>  178

Glu Val Gln Leu Val Gln Ser Gly Ser Lys Leu Glu Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Thr Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Asn Thr Gly Asp Pro Thr Tyr Ala Gln Gly Phe 
    50                  55                  60                  


Thr Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Ser Thr Ala Phe 
65                  70                  75                  80  


Leu Gln Ile Asn Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gly Asp Cys Asp Ser Thr Ser Cys Tyr Arg Tyr Ser Tyr Gly 
            100                 105                 110         


Tyr Glu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125         


<210>  179
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  member of supercluster10

<400>  179

Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Asn Thr Gly Asn Pro Thr Tyr Ala Gln Gly Phe 
    50                  55                  60                  


Thr Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Ser Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gly Asp Cys Asp Ser Thr Ser Cys Tyr Arg Tyr Ser Tyr Gly 
            100                 105                 110         


Tyr Glu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125         


<210>  180
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  member of supercluster10

<400>  180

Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Asn Thr Gly Asp Pro Thr Tyr Ala Gln Gly Phe 
    50                  55                  60                  


Thr Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Ser Thr Ala Phe 
65                  70                  75                  80  


Leu Gln Ile Asn Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gly Asp Cys Asp Ser Thr Asn Cys Tyr Arg Tyr Ser Tyr Gly 
            100                 105                 110         


Tyr Glu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125         


<210>  181
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  member of supercluster10

<400>  181

Gln Val Gln Leu Val Gln Ser Gly Ser Thr Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Thr Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asp Thr Asn Thr Gly Asp Pro Thr Tyr Ala Gln Gly Phe 
    50                  55                  60                  


Thr Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Thr Thr Ala Phe 
65                  70                  75                  80  


Leu Gln Ile Asn Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gly Asp Cys Asp Ser Thr Ser Cys Tyr Arg Tyr Ser Tyr Gly 
            100                 105                 110         


Tyr Glu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125         


