                         SEQUENCE LISTING

<110>  Oxford University Innovation Limited
 
<120>  BIOMOLECULE SEPARATION AND MODIFICATION

<130>  JDM79712P.WOP

<150>  GB1518477.3
<151>  2015-10-19

<160>  61    

<170>  PatentIn version 3.5

<210>  1
<211>  250
<212>  PRT
<213>  Homo sapiens

<400>  1

Gly Ala Met Gly Ser Met Gly Asp Glu Asp Trp Glu Ala Glu Ile Asn 
1               5                   10                  15      


Pro His Met Ser Ser Tyr Val Pro Ile Phe Glu Lys Asp Arg Tyr Ser 
            20                  25                  30          


Gly Glu Asn Gly Asp Asn Phe Asn Arg Thr Pro Ala Ser Ser Ser Glu 
        35                  40                  45              


Met Asp Asp Gly Pro Ser Arg Arg Asp His Phe Met Lys Ser Gly Phe 
    50                  55                  60                  


Ala Ser Gly Arg Asn Phe Gly Asn Arg Asp Ala Gly Glu Cys Asn Lys 
65                  70                  75                  80  


Arg Asp Asn Thr Ser Thr Met Gly Gly Phe Gly Val Gly Lys Ser Phe 
                85                  90                  95      


Gly Asn Arg Gly Phe Ser Asn Ser Arg Phe Glu Asp Gly Asp Ser Ser 
            100                 105                 110         


Gly Phe Trp Arg Glu Ser Ser Asn Asp Cys Glu Asp Asn Pro Thr Arg 
        115                 120                 125             


Asn Arg Gly Phe Ser Lys Arg Gly Gly Tyr Arg Asp Gly Asn Asn Ser 
    130                 135                 140                 


Glu Ala Ser Gly Pro Tyr Arg Arg Gly Gly Arg Gly Ser Phe Arg Gly 
145                 150                 155                 160 


Cys Arg Gly Gly Phe Gly Leu Gly Ser Pro Asn Asn Asp Leu Asp Pro 
                165                 170                 175     


Asp Glu Cys Met Gln Arg Thr Gly Gly Leu Phe Gly Ser Arg Arg Pro 
            180                 185                 190         


Val Leu Ser Gly Thr Gly Asn Gly Asp Thr Ser Gln Ser Arg Ser Gly 
        195                 200                 205             


Ser Gly Ser Glu Arg Gly Gly Tyr Lys Gly Leu Asn Glu Glu Val Ile 
    210                 215                 220                 


Thr Gly Ser Gly Lys Asn Ser Trp Lys Ser Glu Ala Glu Gly Gly Glu 
225                 230                 235                 240 


Ser Ser Asp Thr Gln Gly Pro Lys Val Thr 
                245                 250 


<210>  2
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GFP synthetic construct

<400>  2

Met His His His His His His Met Ser Lys Gly Glu Glu Leu Phe Thr 
1               5                   10                  15      


Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp Val Asn Gly His 
            20                  25                  30          


Lys Phe Ser Val Arg Gly Glu Gly Glu Gly Asp Ala Thr Asn Gly Lys 
        35                  40                  45              


Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu Pro Val Pro Trp 
    50                  55                  60                  


Pro Thr Leu Val Thr Thr Leu Gly Tyr Gly Val Gln Cys Phe Ser Arg 
65                  70                  75                  80  


Tyr Pro Asp His Met Lys Arg His Asp Phe Phe Lys Ser Ala Met Pro 
                85                  90                  95      


Glu Gly Tyr Val Gln Glu Arg Thr Ile Ser Phe Lys Asp Asp Gly Thr 
            100                 105                 110         


Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp Thr Leu Val Asn 
        115                 120                 125             


Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu 
    130                 135                 140                 


Gly His Lys Leu Glu Tyr Asn Phe Asn Ser His Asn Val Tyr Ile Thr 
145                 150                 155                 160 


Ala Asp Lys Gln Lys Asn Gly Ile Lys Ala Asn Phe Lys Ile Arg His 
                165                 170                 175     


Asn Val Glu Asp Gly Ser Val Gln Leu Ala Asp His Tyr Gln Gln Asn 
            180                 185                 190         


Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp Asn His Tyr Leu 
        195                 200                 205             


Ser Thr Gln Ser Val Leu Ser Lys Asp Pro Asn Glu Lys Arg Asp His 
    210                 215                 220                 


Met Val Leu Leu Glu Phe Val Thr Ala Ala Gly Ile Thr His Gly 
225                 230                 235                 


<210>  3
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GFP synthetic construct

<400>  3

Met His His His His His His Met Ser Lys Gly Glu Arg Leu Phe Thr 
1               5                   10                  15      


Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp Val Asn Gly His 
            20                  25                  30          


Lys Phe Ser Val Arg Gly Glu Gly Glu Gly Asp Ala Thr Arg Gly Lys 
        35                  40                  45              


Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu Pro Val Pro Trp 
    50                  55                  60                  


Pro Thr Leu Val Thr Thr Leu Thr Tyr Gly Val Gln Cys Phe Ser Arg 
65                  70                  75                  80  


Tyr Pro Lys His Met Lys Arg His Asp Phe Phe Lys Ser Ala Met Pro 
                85                  90                  95      


Glu Gly Tyr Val Gln Glu Arg Thr Ile Ser Phe Lys Lys Asp Gly Thr 
            100                 105                 110         


Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Arg Thr Leu Val Asn 
        115                 120                 125             


Arg Ile Glu Leu Lys Gly Arg Asp Phe Lys Glu Lys Gly Asn Ile Leu 
    130                 135                 140                 


Gly His Lys Leu Glu Tyr Asn Phe Asn Ser His Asn Val Tyr Ile Thr 
145                 150                 155                 160 


Ala Asp Lys Arg Lys Asn Gly Ile Lys Ala Asn Phe Lys Ile Arg His 
                165                 170                 175     


Asn Val Lys Asp Gly Ser Val Gln Leu Ala Asp His Tyr Gln Gln Asn 
            180                 185                 190         


Thr Pro Ile Gly Arg Gly Pro Val Leu Leu Pro Arg Asn His Tyr Leu 
        195                 200                 205             


Ser Thr Arg Ser Ala Leu Ser Lys Asp Pro Lys Glu Lys Arg Asp His 
    210                 215                 220                 


Met Val Leu Leu Glu Phe Val Thr Ala Ala Gly Ile Thr His Gly Met 
225                 230                 235                 240 


Asp Glu Leu Tyr Lys 
                245 


<210>  4
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GFP synthetic construct

<400>  4

Met His His His His His His Met Ser Lys Gly Glu Glu Leu Phe Asp 
1               5                   10                  15      


Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp Val Asn Gly His 
            20                  25                  30          


Glu Phe Ser Val Arg Gly Glu Gly Glu Gly Asp Ala Thr Glu Gly Glu 
        35                  40                  45              


Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly Glu Leu Pro Val Pro Trp 
    50                  55                  60                  


Pro Thr Leu Val Thr Thr Leu Thr Tyr Gly Val Gln Cys Phe Ser Asp 
65                  70                  75                  80  


Tyr Pro Asp His Met Asp Gln His Asp Phe Phe Lys Ser Ala Met Pro 
                85                  90                  95      


Glu Gly Tyr Val Gln Glu Arg Thr Ile Ser Phe Lys Asp Asp Gly Thr 
            100                 105                 110         


Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp Thr Leu Val Asn 
        115                 120                 125             


Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu 
    130                 135                 140                 


Gly His Lys Leu Glu Tyr Asn Phe Asn Ser His Asp Val Tyr Ile Thr 
145                 150                 155                 160 


Ala Asp Lys Gln Glu Asn Gly Ile Lys Ala Glu Phe Glu Ile Arg His 
                165                 170                 175     


Asn Val Glu Asp Gly Ser Val Gln Leu Ala Asp His Tyr Gln Gln Asn 
            180                 185                 190         


Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp Asp His Tyr Leu 
        195                 200                 205             


Ser Thr Glu Ser Ala Leu Ser Lys Asp Pro Asn Glu Asp Arg Asp His 
    210                 215                 220                 


Met Val Leu Leu Glu Phe Val Thr Ala Ala Gly Ile Asp His Gly Met 
225                 230                 235                 240 


Asp Glu Leu Tyr Lys 
                245 


<210>  5
<211>  474
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein

<400>  5

Gly Ala Met Gly Ser Met Gly Asp Glu Asp Trp Glu Ala Glu Ile Asn 
1               5                   10                  15      


Pro His Met Ser Ser Tyr Val Pro Ile Phe Glu Lys Asp Arg Tyr Ser 
            20                  25                  30          


Gly Glu Asn Gly Asp Asn Phe Asn Arg Thr Pro Ala Ser Ser Ser Glu 
        35                  40                  45              


Met Asp Asp Gly Pro Ser Arg Arg Asp His Phe Met Lys Ser Gly Phe 
    50                  55                  60                  


Ala Ser Gly Arg Asn Phe Gly Asn Arg Asp Ala Gly Glu Cys Asn Lys 
65                  70                  75                  80  


Arg Asp Asn Thr Ser Thr Met Gly Gly Phe Gly Val Gly Lys Ser Phe 
                85                  90                  95      


Gly Asn Arg Gly Phe Ser Asn Ser Arg Phe Glu Asp Gly Asp Ser Ser 
            100                 105                 110         


Gly Phe Trp Arg Glu Ser Ser Asn Asp Cys Glu Asp Asn Pro Thr Arg 
        115                 120                 125             


Asn Arg Gly Phe Ser Lys Arg Gly Gly Tyr Arg Asp Gly Asn Asn Ser 
    130                 135                 140                 


Glu Ala Ser Gly Pro Tyr Arg Arg Gly Gly Arg Gly Ser Phe Arg Gly 
145                 150                 155                 160 


Cys Arg Gly Gly Phe Gly Leu Gly Ser Pro Asn Asn Asp Leu Asp Pro 
                165                 170                 175     


Asp Glu Cys Met Gln Arg Thr Gly Gly Leu Phe Gly Ser Arg Arg Pro 
            180                 185                 190         


Val Leu Ser Gly Thr Gly Asn Gly Asp Thr Ser Gln Ser Arg Ser Gly 
        195                 200                 205             


Ser Gly Ser Glu Arg Gly Gly Tyr Lys Gly Leu Asn Glu Glu Val Ile 
    210                 215                 220                 


Thr Gly Ser Gly Lys Asn Ser Trp Lys Ser Glu Ala Glu Gly Gly Glu 
225                 230                 235                 240 


Ser Val Asp Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val 
                245                 250                 255     


Pro Ile Leu Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser 
            260                 265                 270         


Val Ser Gly Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu 
        275                 280                 285             


Lys Phe Ile Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu 
    290                 295                 300                 


Val Thr Thr Phe Gly Tyr Gly Leu Met Cys Phe Ala Arg Tyr Pro Asp 
305                 310                 315                 320 


His Met Lys Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr 
                325                 330                 335     


Val Gln Glu Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr 
            340                 345                 350         


Arg Ala Glu Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu 
        355                 360                 365             


Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys 
    370                 375                 380                 


Leu Glu Tyr Asn Tyr Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys 
385                 390                 395                 400 


Gln Lys Asn Gly Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile Glu 
                405                 410                 415     


Asp Gly Ser Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile 
            420                 425                 430         


Gly Asp Gly Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Tyr Gln 
        435                 440                 445             


Ser Lys Leu Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu 
    450                 455                 460                 


Leu Glu Phe Val Thr Ala Ala Gly Ile Thr 
465                 470                 


<210>  6
<211>  535
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein

<400>  6

Gly Ala Met Gly Ser Asn Met Gly Asp Glu Asp Trp Glu Ala Glu Ile 
1               5                   10                  15      


Asn Pro His Met Ser Ser Tyr Val Pro Ile Phe Glu Lys Asp Arg Tyr 
            20                  25                  30          


Ser Gly Glu Asn Gly Asp Asn Phe Asn Arg Thr Pro Ala Ser Ser Ser 
        35                  40                  45              


Glu Met Asp Asp Gly Pro Ser Arg Arg Asp His Phe Met Lys Ser Gly 
    50                  55                  60                  


Phe Ala Ser Gly Arg Asn Phe Gly Asn Arg Asp Ala Gly Glu Cys Asn 
65                  70                  75                  80  


Lys Arg Asp Asn Thr Ser Thr Met Gly Gly Phe Gly Val Gly Lys Ser 
                85                  90                  95      


Phe Gly Asn Arg Gly Phe Ser Asn Ser Arg Phe Glu Asp Gly Asp Ser 
            100                 105                 110         


Ser Gly Phe Trp Arg Glu Ser Ser Asn Asp Cys Glu Asp Asn Pro Thr 
        115                 120                 125             


Arg Asn Arg Gly Phe Ser Lys Arg Gly Gly Tyr Arg Asp Gly Asn Asn 
    130                 135                 140                 


Ser Glu Ala Ser Gly Pro Tyr Arg Arg Gly Gly Arg Gly Ser Phe Arg 
145                 150                 155                 160 


Gly Cys Arg Gly Gly Phe Gly Leu Gly Ser Pro Asn Asn Asp Leu Asp 
                165                 170                 175     


Pro Asp Glu Cys Met Gln Arg Thr Gly Gly Leu Phe Gly Ser Arg Arg 
            180                 185                 190         


Pro Val Leu Ser Gly Thr Gly Asn Gly Asp Thr Ser Gln Ser Arg Ser 
        195                 200                 205             


Gly Ser Gly Ser Glu Arg Gly Gly Tyr Lys Gly Leu Asn Glu Glu Val 
    210                 215                 220                 


Ile Thr Gly Ser Gly Lys Asn Ser Trp Lys Ser Glu Ala Glu Gly Gly 
225                 230                 235                 240 


Glu Ser Ser Asp Thr Gln Gly Pro Lys Val Thr Leu Gln Met Val Ser 
                245                 250                 255     


Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu 
            260                 265                 270         


Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly Glu Gly Glu 
        275                 280                 285             


Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr 
    290                 295                 300                 


Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Phe Gly Tyr 
305                 310                 315                 320 


Gly Leu Met Cys Phe Ala Arg Tyr Pro Asp His Met Lys Gln His Asp 
                325                 330                 335     


Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile 
            340                 345                 350         


Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe 
        355                 360                 365             


Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe 
    370                 375                 380                 


Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn Tyr Asn 
385                 390                 395                 400 


Ser His Asn Val Tyr Ile Met Ala Asp Lys Gln Lys Asn Gly Ile Lys 
                405                 410                 415     


Val Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser Val Gln Leu 
            420                 425                 430         


Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu 
        435                 440                 445             


Leu Pro Asp Asn His Tyr Leu Ser Tyr Gln Ser Lys Leu Ser Lys Asp 
    450                 455                 460                 


Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe Val Thr Ala 
465                 470                 475                 480 


Ala Gly Ile Thr Leu Glu Phe Ser Thr Tyr Ile Pro Gly Phe Ser Gly 
                485                 490                 495     


Ser Thr Arg Gly Asn Val Phe Ala Ser Val Asp Thr Arg Lys Gly Lys 
            500                 505                 510         


Ser Thr Leu Asn Thr Ala Gly Phe Ser Ser Ser Gln Ala Pro Asn Pro 
        515                 520                 525             


Val Asp Asp Glu Ser Trp Asp 
    530                 535 


<210>  7
<211>  535
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein

<400>  7

Gly Ala Met Gly Ser Asn Met Gly Asp Glu Asp Trp Glu Ala Glu Ile 
1               5                   10                  15      


Asn Pro His Met Ser Ser Tyr Val Pro Ile Phe Glu Lys Asp Arg Tyr 
            20                  25                  30          


Ser Gly Glu Asn Gly Asp Asn Phe Asn Arg Thr Pro Ala Ser Ser Ser 
        35                  40                  45              


Glu Met Asp Asp Gly Pro Ser Arg Arg Asp His Phe Met Lys Ser Gly 
    50                  55                  60                  


Ala Ala Ser Gly Arg Asn Ala Gly Asn Arg Asp Ala Gly Glu Cys Asn 
65                  70                  75                  80  


Lys Arg Asp Asn Thr Ser Thr Met Gly Gly Ala Gly Val Gly Lys Ser 
                85                  90                  95      


Ala Gly Asn Arg Gly Ala Ser Asn Ser Arg Phe Glu Asp Gly Asp Ser 
            100                 105                 110         


Ser Gly Phe Trp Arg Glu Ser Ser Asn Asp Cys Glu Asp Asn Pro Thr 
        115                 120                 125             


Arg Asn Arg Gly Ala Ser Lys Arg Gly Gly Tyr Arg Asp Gly Asn Asn 
    130                 135                 140                 


Ser Glu Ala Ser Gly Pro Tyr Arg Arg Gly Gly Arg Gly Ser Ala Arg 
145                 150                 155                 160 


Gly Cys Arg Gly Gly Ala Gly Leu Gly Ser Pro Asn Asn Asp Leu Asp 
                165                 170                 175     


Pro Asp Glu Cys Met Gln Arg Thr Gly Gly Leu Ala Gly Ser Arg Arg 
            180                 185                 190         


Pro Val Leu Ser Gly Thr Gly Asn Gly Asp Thr Ser Gln Ser Arg Ser 
        195                 200                 205             


Gly Ser Gly Ser Glu Arg Gly Gly Tyr Lys Gly Leu Asn Glu Glu Val 
    210                 215                 220                 


Ile Thr Gly Ser Gly Lys Asn Ser Trp Lys Ser Glu Ala Glu Gly Gly 
225                 230                 235                 240 


Glu Ser Ser Asp Thr Gln Gly Pro Lys Val Thr Leu Gln Met Val Ser 
                245                 250                 255     


Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu 
            260                 265                 270         


Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly Glu Gly Glu 
        275                 280                 285             


Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr 
    290                 295                 300                 


Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Phe Gly Tyr 
305                 310                 315                 320 


Gly Leu Met Cys Phe Ala Arg Tyr Pro Asp His Met Lys Gln His Asp 
                325                 330                 335     


Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile 
            340                 345                 350         


Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe 
        355                 360                 365             


Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe 
    370                 375                 380                 


Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn Tyr Asn 
385                 390                 395                 400 


Ser His Asn Val Tyr Ile Met Ala Asp Lys Gln Lys Asn Gly Ile Lys 
                405                 410                 415     


Val Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser Val Gln Leu 
            420                 425                 430         


Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu 
        435                 440                 445             


Leu Pro Asp Asn His Tyr Leu Ser Tyr Gln Ser Lys Leu Ser Lys Asp 
    450                 455                 460                 


Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe Val Thr Ala 
465                 470                 475                 480 


Ala Gly Ile Thr Leu Glu Ala Ser Thr Tyr Ile Pro Gly Ala Ser Gly 
                485                 490                 495     


Ser Thr Arg Gly Asn Val Phe Ala Ser Val Asp Thr Arg Lys Gly Lys 
            500                 505                 510         


Ser Thr Leu Asn Thr Ala Gly Phe Ser Ser Ser Gln Ala Pro Asn Pro 
        515                 520                 525             


Val Asp Asp Glu Ser Trp Asp 
    530                 535 


<210>  8
<211>  261
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YFP synthetic construct

<400>  8

Gly Ala Met Gly Ser Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly 
1               5                   10                  15      


Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp Val Asn Gly His Lys 
            20                  25                  30          


Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu 
        35                  40                  45              


Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro 
    50                  55                  60                  


Thr Leu Val Thr Thr Phe Gly Tyr Gly Leu Met Cys Phe Ala Arg Tyr 
65                  70                  75                  80  


Pro Asp His Met Lys Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu 
                85                  90                  95      


Gly Tyr Val Gln Glu Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr 
            100                 105                 110         


Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg 
        115                 120                 125             


Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly 
    130                 135                 140                 


His Lys Leu Glu Tyr Asn Tyr Asn Ser His Asn Val Tyr Ile Met Ala 
145                 150                 155                 160 


Asp Lys Gln Lys Asn Gly Ile Lys Val Asn Phe Lys Ile Arg His Asn 
                165                 170                 175     


Ile Glu Asp Gly Ser Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr 
            180                 185                 190         


Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser 
        195                 200                 205             


Tyr Gln Ser Lys Leu Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met 
    210                 215                 220                 


Val Leu Leu Glu Phe Val Thr Ala Ala Gly Ile Thr Leu Glu Arg Pro 
225                 230                 235                 240 


Leu Ser Asn Leu Glu Pro Ala Val Ser Arg His Ala Val Pro Ser Phe 
                245                 250                 255     


Lys Leu Ser Asn Asn 
            260     


<210>  9
<211>  405
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein

<400>  9

Met Phe Gly Arg Asp Pro Phe Asp Ser Leu Phe Glu Arg Met Phe Lys 
1               5                   10                  15      


Glu Phe Phe Ala Thr Pro Met Thr Gly Thr Thr Met Ile Gln Ser Ser 
            20                  25                  30          


Thr Gly Ile Gln Ile Ser Gly Lys Gly Phe Met Pro Ile Ser Ile Ile 
        35                  40                  45              


Glu Gly Asp Gln His Ile Lys Val Ile Ala Trp Leu Pro Gly Val Asn 
    50                  55                  60                  


Lys Glu Asp Ile Ile Leu Asn Ala Val Gly Asp Thr Leu Glu Ile Arg 
65                  70                  75                  80  


Ala Lys Arg Ser Pro Leu Met Ile Thr Glu Ser Glu Arg Ile Ile Tyr 
                85                  90                  95      


Ser Glu Ile Pro Glu Glu Glu Glu Ile Tyr Arg Thr Ile Lys Leu Pro 
            100                 105                 110         


Ala Thr Val Lys Glu Glu Asn Ala Ser Ala Lys Phe Glu Asn Gly Val 
        115                 120                 125             


Leu Ser Val Ile Leu Pro Lys Ala Glu Ser Ser Ile Lys Lys Gly Ile 
    130                 135                 140                 


Asn Ile Glu Ala Ser Gly Glu Asn Leu Tyr Phe Gln Ser Leu Ser Lys 
145                 150                 155                 160 


Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp 
                165                 170                 175     


Gly Asp Val Asn Gly His Lys Phe Ser Val Arg Gly Glu Gly Glu Gly 
            180                 185                 190         


Asp Ala Thr Asn Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly 
        195                 200                 205             


Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Leu Thr Tyr Gly 
    210                 215                 220                 


Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys Gln His Asp Phe 
225                 230                 235                 240 


Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Ser 
                245                 250                 255     


Phe Lys Asp Asp Gly Thr Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu 
            260                 265                 270         


Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys 
        275                 280                 285             


Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn Phe Asn Ser 
    290                 295                 300                 


His Asn Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn Gly Ile Lys Ala 
305                 310                 315                 320 


Asn Phe Lys Ile Arg His Asn Val Glu Asp Gly Ser Val Gln Leu Ala 
                325                 330                 335     


Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu 
            340                 345                 350         


Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Val Leu Ser Lys Asp Pro 
        355                 360                 365             


Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe Val Thr Ala Ala 
    370                 375                 380                 


Gly Ile Thr His Gly Met Asp Glu Leu Tyr Lys Lys Gly Leu Glu His 
385                 390                 395                 400 


His His His His His 
                405 


<210>  10
<211>  433
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein

<400>  10

Met Asp Ile Ala Ile His His Pro Trp Ile Arg Arg Pro Phe Phe Pro 
1               5                   10                  15      


Phe His Ser Pro Ser Arg Leu Phe Asp Gln Phe Phe Gly Glu His Leu 
            20                  25                  30          


Leu Glu Ser Asp Leu Phe Pro Thr Ser Thr Ser Leu Ser Pro Phe Tyr 
        35                  40                  45              


Leu Arg Pro Pro Ser Phe Leu Arg Ala Pro Ser Trp Phe Asp Thr Gly 
    50                  55                  60                  


Leu Ser Glu Met Arg Leu Glu Lys Asp Arg Phe Ser Val Asn Leu Asp 
65                  70                  75                  80  


Val Lys His Phe Ser Pro Glu Glu Leu Lys Val Lys Val Leu Gly Asp 
                85                  90                  95      


Val Ile Glu Val His Gly Lys His Glu Glu Arg Gln Asp Glu His Gly 
            100                 105                 110         


Phe Ile Ser Arg Glu Phe His Arg Lys Tyr Arg Ile Pro Ala Asp Val 
        115                 120                 125             


Asp Pro Leu Thr Ile Thr Ser Ser Leu Ser Ser Asp Gly Val Leu Thr 
    130                 135                 140                 


Val Asn Gly Pro Arg Lys Gln Val Ser Gly Pro Glu Arg Thr Ile Pro 
145                 150                 155                 160 


Ile Thr Arg Glu Glu Lys Pro Ala Val Thr Ala Ala Pro Lys Lys Ala 
                165                 170                 175     


Ser Gly Glu Asn Leu Tyr Phe Gln Ser Leu Ser Lys Gly Glu Glu Leu 
            180                 185                 190         


Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp Val Asn 
        195                 200                 205             


Gly His Lys Phe Ser Val Arg Gly Glu Gly Glu Gly Asp Ala Thr Asn 
    210                 215                 220                 


Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu Pro Val 
225                 230                 235                 240 


Pro Trp Pro Thr Leu Val Thr Thr Leu Thr Tyr Gly Val Gln Cys Phe 
                245                 250                 255     


Ser Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys Ser Ala 
            260                 265                 270         


Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Ser Phe Lys Asp Asp 
        275                 280                 285             


Gly Thr Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp Thr Leu 
    290                 295                 300                 


Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly Asn 
305                 310                 315                 320 


Ile Leu Gly His Lys Leu Glu Tyr Asn Phe Asn Ser His Asn Val Tyr 
                325                 330                 335     


Ile Thr Ala Asp Lys Gln Lys Asn Gly Ile Lys Ala Asn Phe Lys Ile 
            340                 345                 350         


Arg His Asn Val Glu Asp Gly Ser Val Gln Leu Ala Asp His Tyr Gln 
        355                 360                 365             


Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp Asn His 
    370                 375                 380                 


Tyr Leu Ser Thr Gln Ser Val Leu Ser Lys Asp Pro Asn Glu Lys Arg 
385                 390                 395                 400 


Asp His Met Val Leu Leu Glu Phe Val Thr Ala Ala Gly Ile Thr His 
                405                 410                 415     


Gly Met Asp Glu Leu Tyr Lys Lys Gly Leu Glu His His His His His 
            420                 425                 430         


His 
    


<210>  11
<211>  350
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein

<400>  11

Cys Phe Pro Phe Val Thr Ala Ala Gly Ile Thr Gly Ala Met Gly Ser 
1               5                   10                  15      


Met Thr Gly Arg Ala Arg Ala Arg Ala Arg Gly Arg Ala Arg Gly Gln 
            20                  25                  30          


Glu Thr Ala Gln Leu Val Gly Ser Thr Ala Ser Gln Gln Pro Gly Tyr 
        35                  40                  45              


Ile Gln Pro Arg Pro Gln Pro Pro Pro Ala Glu Gly Glu Leu Phe Gly 
    50                  55                  60                  


Arg Gly Arg Gln Arg Gly Thr Ala Gly Gly Thr Ala Lys Ser Gln Gly 
65                  70                  75                  80  


Leu Gln Ile Ser Ala Gly Phe Gln Glu Leu Ser Leu Ala Glu Arg Gly 
                85                  90                  95      


Gly Arg Arg Arg Asp Phe His Asp Leu Gly Val Asn Thr Arg Gln Asn 
            100                 105                 110         


Leu Asp His Val Lys Glu Ser Lys Thr Gly Ser Ser Gly Val Asp Met 
        115                 120                 125             


Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val 
    130                 135                 140                 


Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly Glu 
145                 150                 155                 160 


Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys 
                165                 170                 175     


Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Leu 
            180                 185                 190         


Thr Trp Gly Val Gln Cys Phe Ala Arg Tyr Pro Asp His Met Lys Gln 
        195                 200                 205             


His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg 
    210                 215                 220                 


Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val 
225                 230                 235                 240 


Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile 
                245                 250                 255     


Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn 
            260                 265                 270         


Ala Ile Ser Asp Asn Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn Gly 
        275                 280                 285             


Ile Lys Ala Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser Val 
    290                 295                 300                 


Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro 
305                 310                 315                 320 


Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Lys Leu Ser 
                325                 330                 335     


Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu 
            340                 345                 350 


<210>  12
<211>  12
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide

<400>  12
actgactgac tg                                                           12


<210>  13
<211>  12
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide

<400>  13
cagtcagtca gt                                                           12


<210>  14
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide

<400>  14
actgactgac tgactg                                                       16


<210>  15
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide

<400>  15
cagtcagtca gtcagt                                                       16


<210>  16
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide

<400>  16
actgactgac tgactgactg                                                   20


<210>  17
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide

<400>  17
cagtcagtca gtcagtcagt                                                   20


<210>  18
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide

<400>  18

Ala Cys Thr Gly Ala Cys Thr Gly Ala Cys Thr Gly Ala Cys Thr Gly 
1               5                   10                  15      


Ala Cys Thr Gly 
            20  


<210>  19
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide

<400>  19
cagtcagtca gtcagtcagt cagt                                              24


<210>  20
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide

<400>  20
actgactgac tgactgactg actgactg                                          28


<210>  21
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide

<400>  21
cagtcagtca gtcagtcagt cagtcagt                                          28


<210>  22
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide

<400>  22
actgactgac tgactgactg actgactgac tg                                     32


<210>  23
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide

<400>  23
cagtcagtca gtcagtcagt cagtcagtca gt                                     32


<210>  24
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide

<400>  24
actgactgac tgactgactg actgactgac tgactg                                 36


<210>  25
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide

<400>  25
cagtcagtca gtcagtcagt cagtcagtca gtcagt                                 36


<210>  26
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide

<400>  26
actgactgac tgactgactg actgactgac tgactgactg                             40


<210>  27
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Olignucleotide

<400>  27
cagtcagtca gtcagtcagt cagtcagtca gtcagtcagt                             40


<210>  28
<211>  12
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide

<400>  28
actgactgac tg                                                           12


<210>  29
<211>  12
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide

<400>  29
actgactgac tg                                                           12


<210>  30
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide

<400>  30
actgactgac tgactg                                                       16


<210>  31
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide

<400>  31
actgactgac tgactg                                                       16


<210>  32
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide

<400>  32
actgactgac tgactgactg                                                   20


<210>  33
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide

<400>  33
actgactgac tgactgactg                                                   20


<210>  34
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide

<400>  34
actgactgac tgactgactg actg                                              24


<210>  35
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide

<400>  35
actgactgac tgactgactg actg                                              24


<210>  36
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide

<400>  36
actgactgac tgactgactg actgactg                                          28


<210>  37
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide

<400>  37
actgactgac tgactgactg actgactg                                          28


<210>  38
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide

<400>  38
actgactgac tgactgactg actgactgac tg                                     32


<210>  39
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide

<400>  39
actgactgac tgactgactg actgactgac tg                                     32


<210>  40
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide

<400>  40
actgactgac tgactgactg actgactgac tgactg                                 36


<210>  41
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide

<400>  41
actgactgac tgactgactg actgactgac tgactg                                 36


<210>  42
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide

<400>  42
actgactgac tgactgactg actgactgac tgactgactg                             40


<210>  43
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide

<400>  43
actgactgac tgactgactg actgactgac tgactgactg                             40


<210>  44
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide

<400>  44
acugacugac ug                                                           12


<210>  45
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide

<400>  45
cagucaguca gu                                                           12


<210>  46
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide

<400>  46
acugacugac ugacugacug acug                                              24


<210>  47
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide

<400>  47
cagucaguca gucagucagu cagu                                              24


<210>  48
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide

<400>  48
acugacugac ugacugacug acug                                              24


<210>  49
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide

<400>  49
cagtcagtca gtcagtcagt cagt                                              24


<210>  50
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide

<400>  50
acugacugac ug                                                           12


<210>  51
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide

<400>  51
acugacugac ug                                                           12


<210>  52
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide

<400>  52
acugacugac ugacugacug acug                                              24


<210>  53
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide

<400>  53
acugacugac ugacugacug acug                                              24


<210>  54
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide

<400>  54
ggcggctttt tttttttttt ttttttgccg cc                                     32


<210>  55
<211>  32
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide

<400>  55
ggcggcuuuu uuuuuuuuuu uuuuuugccg cc                                     32


<210>  56
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide

<400>  56
ggcggcggtt tttttttttt ttttttttcc gccgcc                                 36


<210>  57
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide

<400>  57
ggcggcggcg tttttttttt tttttttttt cgccgccgcc                             40


<210>  58
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide

<400>  58
ugagguagua gguuguauag uu                                                22


<210>  59
<211>  28
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide

<400>  59
uaccacuuag aacacaggau gucagcgc                                          28


<210>  60
<211>  30
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide

<400>  60
ugugaaugga aguccaagga ucuagcaguu                                        30


<210>  61
<211>  32
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide

<400>  61
ugaaacucca aaguuucucc aaggcaaaag ac                                     32


